Academic literature on the topic 'VDrama'

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Journal articles on the topic "VDrama"

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Rayego-Mateos, Sandra, Jose Luis Morgado-Pascual, José Manuel Valdivielso, et al. "TRAF3 Modulation: Novel Mechanism for the Anti-inflammatory Effects of the Vitamin D Receptor Agonist Paricalcitol in Renal Disease." Journal of the American Society of Nephrology 31, no. 9 (2020): 2026–42. http://dx.doi.org/10.1681/asn.2019111206.

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BackgroundCKD leads to vitamin D deficiency. Treatment with vitamin D receptor agonists (VDRAs) may have nephroprotective and anti-inflammatory actions, but their mechanisms of action are poorly understood.MethodsModulation of the noncanonical NF-κB2 pathway and its component TNF receptor–associated factor 3 (TRAF3) by the VDRA paricalcitol was studied in PBMCs from patients with ESKD, cytokine-stimulated cells, and preclinical kidney injury models.ResultsIn PBMCs isolated from patients with ESKD, TRAF3 protein levels were lower than in healthy controls. This finding was associated with eviden
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Banks, Mindy, and Stuart M. Sprague. "Vitamin D and Peritoneal Dialysis." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 28, no. 2_suppl (2008): 33–37. http://dx.doi.org/10.1177/089686080802802s06.

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Chronic kidney disease – mineral and bone disorder (CKD–MBD) is a cause of significant morbidity and mortality in patients with long-standing kidney disease. Management of secondary hyperparathyroidism includes the use of phosphorus-binding agents and treatment with activated vitamin D compounds, better referred to as vitamin D receptor agonists (VDRAs). In an effort to maximize the therapeutic response while reducing the adverse effects of calcitriol, the naturally synthesized hormone, the use of intravenous administration and several selective VDRAs have been developed. Recently, oral prepar
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Lim, Kenneth, Guerman Molostvov, Maria Lubczanska, et al. "Impaired arterial vitamin D signaling occurs in the development of vascular calcification." PLOS ONE 15, no. 11 (2020): e0241976. http://dx.doi.org/10.1371/journal.pone.0241976.

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Conflicting data exists as to whether vitamin D receptor agonists (VDRa) are protective of arterial calcification. Confounding this, is the inherent physiological differences between human and animal experimental models and our current fragmented understanding of arterial vitamin D metabolism, their alterations in disease states and responses to VDRa’s. Herein, the study aims to address these problems by leveraging frontiers in human arterial organ culture models. Human arteries were collected from a total of 24 patients (healthy controls, n = 12; end-stage CKD, n = 12). Cross-sectional and in
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Morgado-Pascual, Jose L., Sandra Rayego-Mateos, Jose M. Valdivielso, Alberto Ortiz, Jesus Egido, and Marta Ruiz-Ortega. "Paricalcitol Inhibits Aldosterone-Induced Proinflammatory Factors by Modulating Epidermal Growth Factor Receptor Pathway in Cultured Tubular Epithelial Cells." BioMed Research International 2015 (2015): 1–13. http://dx.doi.org/10.1155/2015/783538.

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Chronic kidney disease is characterized by Vitamin D deficiency and activation of the renin-angiotensin-aldosterone system. Increasing data show that vitamin D receptor agonists (VDRAs) exert beneficial effects in renal disease and possess anti-inflammatory properties, but the underlying mechanism remains unknown. Emerging evidence suggests that “a disintegrin and metalloproteinase” (ADAM)/epidermal growth factor receptor (EGFR) signalling axis contributes to renal damage. Aldosterone induces EGFR transactivation regulating several processes including cell proliferation and fibrosis. However,
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Sprague, Stuart M., Adrian C. Covic, Jürgen Floege, et al. "Pharmacodynamic Effects of Sucroferric Oxyhydroxide and Sevelamer Carbonate on Vitamin D Receptor Agonist Bioactivity in Dialysis Patients." American Journal of Nephrology 44, no. 2 (2016): 104–12. http://dx.doi.org/10.1159/000447600.

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Background: Many patients with chronic kidney disease are prescribed vitamin D receptor agonists (VDRAs) for the management of secondary hyperparathyroidism. Oral phosphate binders may interact with, and potentially reduce the therapeutic activity of, oral VDRAs. This post hoc analysis of a Phase 3 study evaluated the pharmacodynamic effects of the iron-based phosphate binder sucroferric oxyhydroxide (SFOH) and sevelamer (SEV) carbonate on VDRA activity in dialysis patients. Methods: One thousand and fifty nine patients were randomized to SFOH 1.0-3.0 g/day (n = 710) or SEV 2.4-14.4 g/day (n =
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Cozzolino, Mario, Florjan Mehmeti, Paola Ciceri, et al. "The Effect of Paricalcitol on Vascular Calcification and Cardiovascular Disease in Uremia: Beyond PTH Control." International Journal of Nephrology 2011 (2011): 1–5. http://dx.doi.org/10.4061/2011/269060.

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Secondary hyperparathyroidism is a systemic disorder that associates with bone and cardiovascular disease, including arterial calcification. Treatment with calcitriol, the active form of vitamin D, reduces parathyroid hormone levels, but may result in elevations in serum calcium and phosphorus, increasing the risk of vascular calcification in dialysis patients. New vitamin D receptor activators (VDRAs) have been developed and investigated with the rationale to treat high serum PTH levels, with a reduced risk of hypercalcemia and hyperphosphatemia. Paricalcitol is a selective VDRA that suppress
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Wu-Wong, J. Ruth, Yung-wu Chen, and Jerry L. Wessale. "Vitamin D receptor agonist VS-105 improves cardiac function in the presence of enalapril in 5/6 nephrectomized rats." American Journal of Physiology-Renal Physiology 308, no. 4 (2015): F309—F319. http://dx.doi.org/10.1152/ajprenal.00129.2014.

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Vitamin D receptor (VDR) agonists (VDRAs) are commonly used to manage hyperparathyroidism secondary to chronic kidney disease (CKD). Patients with CKD experience extremely high risks of cardiovascular morbidity and mortality. Clinical observations show that VDRA therapy may be associated with cardio-renal protective and survival benefits in patients with CKD. The 5/6 nephrectomized (NX) Sprague-Dawley rat with established uremia exhibits elevated serum parathyroid hormone (PTH), hypertension, and abnormal cardiac function. Treatment of 5/6 NX rats with VS-105, a novel VDRA (0.05 and 0.5 μg/kg
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Cianciolo, Giuseppe, Andrea Galassi, Irene Capelli, Maria Laura Angelini, Gaetano La Manna, and Mario Cozzolino. "Vitamin D in Kidney Transplant Recipients: Mechanisms and Therapy." American Journal of Nephrology 43, no. 6 (2016): 397–407. http://dx.doi.org/10.1159/000446863.

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Chronic kidney disease-mineral and bone disorder (CKD-MBD) is common in kidney transplant recipients (KTRs), where secondary hyperparathyroidism (HPTH) and post-transplantation bone disease (PTBD) are potential effectors of both graft and vascular aging. Reduced 25(OH)D levels are highly prevalent in KTRs. Experimental and clinical evidence support the direct involvement of deranged vitamin D metabolism in CKD-MBD among KTRs. This review analyzes the pathophysiology of vitamin D derangement in KTRs and its fall out on patient and graft outcome, highlighting the roles of both nutritional and ac
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Inaguma, Daijo, Yoshitaka Tatematsu, Naoki Okamoto, et al. "Multicentre, open-label, randomised, controlled trial to compare early intervention with calcimimetics and conventional therapy in preventing coronary artery calcification in patients with secondary hyperparathyroidism (UPCOMING): a study protocol." BMJ Open 14, no. 1 (2024): e076962. http://dx.doi.org/10.1136/bmjopen-2023-076962.

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IntroductionCoronary artery and heart valve calcification is a risk factor for cardiovascular death in haemodialysis patients, so calcification prevention should be started as early as possible. Treatment with concomitant calcimimetics and low-dose vitamin D receptor activators (VDRAs) is available, but not enough evidence has been obtained on the efficacy of this regimen, particularly in patients with short dialysis duration. Therefore, this study will evaluate the efficacy and safety of early intervention with upacicalcet, a calcimimetic used to prevent coronary artery calcification in this
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Tai, Sheng-Lun, Yu-Chieng Liou, Juanzhen Sun, Shao-Fan Chang, and Min-Chao Kuo. "Precipitation Forecasting Using Doppler Radar Data, a Cloud Model with Adjoint, and the Weather Research and Forecasting Model: Real Case Studies during SoWMEX in Taiwan." Weather and Forecasting 26, no. 6 (2011): 975–92. http://dx.doi.org/10.1175/waf-d-11-00019.1.

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Abstract The quantitative precipitation forecast (QPF) capability of the Variational Doppler Radar Analysis System (VDRAS) is investigated in the Taiwan area, where the complex topography and surrounding oceans pose great challenges to accurate rainfall prediction. Two real cases observed during intensive operation periods (IOPs) 4 and 8 of the 2008 Southwest Monsoon Experiment (SoWMEX) are selected for this study. Experiments are first carried out to explore the sensitivity of the retrieved fields and model forecasts with respect to different background fields. All results after assimilation
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Dissertations / Theses on the topic "VDrama"

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Chenane, Chabane. "Analyse et reconstruction de la dynamique des véhicules motorisés (VDRM) et détection de situations limites de roulis." Thesis, Evry-Val d'Essonne, 2014. http://www.theses.fr/2014EVRY0037/document.

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Le monde des Véhicules à Deux Roues Motorisés (VDRM) a changé considérablement,en matière de qualité et de performances. Ces véhicules ont pris une place importante dans notre vie quotidienne, que ce soit pour les déplacements ou les loisirs, ce qui a contribué à l’augmentation et à la diversité du parc. Néanmoins, la sécurité des usagers est devenue une des préoccupations des institutions routières et des organismes de recherche, vu le nombre croissant des accidents et la vulnérabilité à laquelle sont confrontés. Nos travaux de recherche s’inscrivent dans la thématique d’étude (modélisation e
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Yang, Ching-yu, and 楊靜伃. "Improving short-term QPF by using a 4DVAR radar data assimilation system (VDRAS) and WRF." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/06282880686618820363.

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碩士<br>國立中央大學<br>大氣物理研究所<br>100<br>The NCAR Variational Doppler Radar Analysis System (VDRAS) is a system which uses the 4DVAR technique to assimilate the radar reflectivity and radial wind observations, and is capable of providing the three-dimensional kinematic and thermodynamic fields within a weather system. Since VDRAS is formulated on a Cartesian coordinate, its application to Taiwan where the topography is complicated is expected to be limited. Previous studies in which the analysis fields from VDRAS were merged with WRF showed encouraging results in improving the model Quantitative Prec
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Kuo, Min-Chao, and 郭閔超. "Improving short-range QPF in Taiwan by VDRAS and WRF using data from multiple weather radars." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/30100864927063636693.

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碩士<br>國立中央大學<br>大氣物理研究所<br>99<br>In this research, the Variational Doppler Radar Analysis System (VDRAS) is used to assimilate radar data. The VDRAS has the capability to conduct forecast, but only over flat surface. Thus, it is attempted to merge the VDRAS analysis field with WRF, so that one can use the latter to resolve the terrain. In this study, we will use RCCG, RCKT, RCHL and S-POL radars to perform a series of assimilation experiments with different strategies. A real case of a shallow surface front occurred from 0500UTC to 0900UTC on 02 June 2008 during Southwest Monsoon Experiment IO
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Chang, Shao-Fan, and 張少凡. "The influence of assimilation strategies and ice-phase microphysics on the application of a four-dimensional Variational Doppler Radar Analysis System (VDRAS) for quantitative precipitation forecasts." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/06292548093300322850.

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博士<br>國立中央大學<br>大氣物理研究所<br>101<br>A series of observation system simulation experiments (OSSEs) and real case study are conducted to investigate the application of the Doppler radar data assimilation technique for numerical model quantitative precipitation forecasts (QPF). A four-dimensional Variational Doppler Radar Analysis System (VDRAS) is adopted for all experiments. The first set of OSSEs demonstrates that when the background field contains the imperfect information predicted from a mesoscale model, the incorrect convective-scale perturbations in the background can result in spurious sca
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Tai, Sheng-Lun, and 戴聖倫. "The Development and Application of a Terrain-Resolving Scheme for the Forward Model and Its Adjoint in the Four-Dimensional Variational Doppler Radar Analysis System (VDRAS)." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/9uz4mj.

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博士<br>國立中央大學<br>大氣科學學系<br>105<br>The four-dimensional Variational Doppler Radar Analysis System (VDRAS) developed at the National Center for Atmospheric Research (NCAR) is significantly improved by implementing a terrain-resolving scheme to its forward model and adjoint based on the Ghost Cell Immersed Boundary Method (GCIBM), which allows the topographic effects to be considered without the necessity to re-build the model on a terrain-following coordinate system. The new system, called IBM_VDRAS, is able to perform forward forecast and backward adjointmodel integration over non-flat lower bou
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Books on the topic "VDrama"

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d1938-, Reynolds Henry. The chant of Jimmie Blacksmith. Currency Press, 2008.

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Book chapters on the topic "VDrama"

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Balsom, Erika. "Transmission, from the Movie-Drome to Vdrome." In After Uniqueness. Columbia University Press, 2017. http://dx.doi.org/10.7312/columbia/9780231176934.003.0009.

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Chapter 8 revisits the utopian moment of exhibiting experimental film and video art on television in light of contemporary efforts to develop authorized platforms for the distribution of artists’ moving image on the Internet. This chapter turns to the life and legacy of the late-night programs Screening Room (1971–81) and Midnight Underground (1993–97), comparing and contrasting the broadcasting model with the recent narrowcasting initiative Vdrome, www.vdrome.org, which shows a single artists’ video for a limited period of time, usually ten days.
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"8. Transmission, from the Movie-Drome to Vdrome." In After Uniqueness. Columbia University Press, 2017. http://dx.doi.org/10.7312/bals17692-010.

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Conference papers on the topic "VDrama"

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Dai, Jie, Lei Han, Wei Zhang, ChangJiang Zhang, and Hanlei Feng. "A deep belief network approach using VDRAS data for nowcasting." In Ninth International Conference on Graphic and Image Processing, edited by Hui Yu and Junyu Dong. SPIE, 2018. http://dx.doi.org/10.1117/12.2303475.

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Roberts, Justin, James MacKrell, D. B. Piyarathna, et al. "Abstract 1817: A novel non-secosteroidal VDR agonist, VDRM2, inhibits prostate tumor growth." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-1817.

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