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Journal articles on the topic 'Vecuronium'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Wright, Peter M. C., Paul Hart, Marie Lau, et al. "The Magnitude and Time Course of Vecuronium Potentiation by Desflurane Versus Isoflurane." Anesthesiology 82, no. 2 (1995): 404–11. http://dx.doi.org/10.1097/00000542-199502000-00011.

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Background Preliminary studies suggest that desflurane and isoflurane potentiate the action of muscle relaxants equally. However, variability between subjects may confound these comparisons. A crossover study was performed in volunteers on the ability of desflurane and isoflurane to potentiate the neuromuscular effect of vecuronium, to influence its duration of action, and on the magnitude and time course of reversal of potentiation when anesthesia was withdrawn. Methods Adductor pollicis twitch tension was monitored in 16 volunteers given 1.25 MAC desflurane on one occasion, and 1.25 MAC isof

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2

Fisher, Dennis M., Janos Szenohradszky, Peter M. C. Wright, Marie Lau, Ronald Brown, and Manohar Sharma. "Pharmacodynamic Modeling of Vecuronium-induced Twitch Depression." Anesthesiology 86, no. 3 (1997): 558–66. http://dx.doi.org/10.1097/00000542-199703000-00007.

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Background After bolus doses of nondepolarizing muscle relaxants, the adductor pollicis recovers from paralysis more slowly than the diaphragm and the laryngeal adductors, suggesting that the adductor pollicis is more sensitive than the respiratory muscles to effects of those drugs. In contrast, during onset, the respiratory muscles are paralyzed more rapidly than the adductor pollicis, suggesting that the respiratory muscles are more sensitive than the adductor pollicis. To reconcile these apparently conflicting findings, we determined vecuronium's pharmacokinetics and its pharmacodynamics at

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3

Wright, Peter M. C., Gerald McCarthy, Janos Szenohradszky, Manohar L. Sharma, and James E. Caldwell. "Influence of Chronic Phenytoin Administration on the Pharmacokinetics and Pharmacodynamics of Vecuronium." Anesthesiology 100, no. 3 (2004): 626–33. http://dx.doi.org/10.1097/00000542-200403000-00024.

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Background The duration of action of vecuronium is reduced in patients receiving phenytoin. In this study, the authors examined, simultaneously, the influence of phenytoin on both the pharmacokinetics and the pharmacodynamics of vecuronium. Methods This study was approved by the institutional review board of the University of California, San Francisco, and patients gave written informed consent. Twenty-two patients, 11 taking phenytoin and all scheduled to undergo prolonged neurosurgical procedures with general anesthesia, participated in the study. In 12 patients (6 phenytoin, 6 control), vec

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4

Blobner, Manfred, Eberhard Kochs, Heidrun Fink, et al. "Pharmacokinetics and Pharmacodynamics of Vecuronium in Rats with Systemic Inflammatory Response Syndrome." Anesthesiology 91, no. 4 (1999): 999. http://dx.doi.org/10.1097/00000542-199910000-00020.

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Background Insufficient detoxification caused by nitric oxide-related inhibition of cytochrome P450 may be important for metabolism of numerous drugs, including vecuronium. The present study investigated the pharmacodynamics and pharmacokinetics of vecuronium in rats with inflammatory liver dysfunction. Methods Male Sprague-Dawley rats (n = 56) were randomly allocated into two groups: In the sepsis group, liver inflammation was established by injection of 56 mg/kg heat-killed Corynebacterium parvum; control rats received the solvent. At day 4, groups were subdivided according to treatment with

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5

Stirt, Joseph A., William Maggio, Charles Haworth, Michael D. Minton, and Robert F. Bedford. "Vecuronium." Anesthesiology 67, no. 4 (1987): 570–72. http://dx.doi.org/10.1097/00000542-198710000-00022.

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6

Beaufort, Ton M., Johannes H. Proost, Jan-Gerard Maring, Emiel R. Scheffer, J. Mark K. H. Wierda, and Dirk K. F. Meijer. "Effect of Hypothermia on the Hepatic Uptake and Biliary Excretion of Vecuronium in the Isolated Perfused Rat Liver." Anesthesiology 94, no. 2 (2001): 270–79. http://dx.doi.org/10.1097/00000542-200102000-00017.

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Background Hypothermia prolongs the time course of action of nondepolarizing muscle relaxants. It is not known whether this prolongation is caused by a reduced rate of extrahepatic distribution or elimination, liver uptake, metabolic clearance, or biliary excretion. Therefore, the authors studied the effects of hypothermia on the net hepatic uptake, metabolism, and biliary excretion of vecuronium in isolated perfused rat liver. Methods Livers of Wistar rats were perfused with Krebs Ringer solution (1% albumin, 3.3% carbon dioxide in oxygen, pH 7.36-7.42, 38 degrees C). Each perfusion experimen

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7

Reich, David L., Ingrid Hollinger, Donna J. Harrington, Howard S. Seiden, Sephali Chakravorti, and D. Ryan Cook. "Comparison of Cisatracurium and Vecuronium by Infusion in Neonates and Small Infants after Congenital Heart Surgery." Anesthesiology 101, no. 5 (2004): 1122–27. http://dx.doi.org/10.1097/00000542-200411000-00011.

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Background Neonates and infants often require extended periods of mechanical ventilation facilitated by sedation and neuromuscular blockade. Methods Twenty-three patients aged younger than 2 yr were randomly assigned to receive either cisatracurium or vecuronium infusions postoperatively in a double-blinded fashion after undergoing congenital heart surgery. The infusion was titrated to maintain one twitch of a train-of-four. The times to full spontaneous recovery of train-of-four without fade, extubation, intensive care unit discharge, and hospital discharge were documented after drug disconti

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8

&NA;. "Vecuronium bromide see Fentanyl/halothane/vecuronium bromide." Reactions Weekly &NA;, no. 367 (1991): 12. http://dx.doi.org/10.2165/00128415-199103670-00063.

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9

Larijani, Ghassem E., Irwin Gratz, Shahab S. Minassian, Deurward L. Hughes, Mary Afshar, and Basil N. Karayannis. "Comparative Evaluation of the Neuromuscular and Cardiovascular Effects of Pipecuronium, Pancuronium, Atracurium, and Vecuronium Under Isoflurane Anesthesia." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 12, no. 4 (1992): 278–82. http://dx.doi.org/10.1002/j.1875-9114.1992.tb04461.x.

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The neuromuscular and cardiovascular effects of intubating doses of pipecuronium 80 μg/kg, pancuronium 100 μg/kg, atracurium 500 μg/kg, and vecuronium 100 μg/kg were compared in 62 patients under isoflurane (end‐tidal concentration = 0.5–1%) anesthesia. Pipecuronium, pancuronium, and vecuronium had no significant effect on systolic or diastolic blood pressure. In one patient the administration of atracurium resulted in significant hypotension. Heart rate was significantly increased only after the administration of pancuronium. The neuromuscular‐blocking effect of pipecuronium and pancuronium a

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10

Wyon, Nicholas, Henning Joensen, Yuji Yamamoto, Sten G. E. Lindahl, and Lars I. Eriksson. "Carotid Body Chemoreceptor Function Is Impaired by Vecuronium during Hypoxia." Anesthesiology 89, no. 6 (1998): 1471–79. http://dx.doi.org/10.1097/00000542-199812000-00025.

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Background Neuromuscular blocking agents reduce the human ventilatory response to hypoxia at partial neuromuscular block. It was hypothesized that vecuronium impairs carotid body chemoreceptor function during hypoxia. Method The effect of systemic administration of vecuronium on single chemoreceptor activity during hypoxia, as recorded from a single nerve fiber preparation of the carotid sinus nerve, was studied in seven mechanically ventilated New Zealand White rabbits during continuous thiopental anesthesia. During normoventilation, the isocapnic hypoxic chemosensitivity of the single caroti

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11

Caldwell, James E., Tom Heier, Peter M. C. Wright, et al. "Temperature-dependent Pharmacokinetics and Pharmacodynamics of Vecuronium." Anesthesiology 92, no. 1 (2000): 84. http://dx.doi.org/10.1097/00000542-200001000-00018.

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Background The authors evaluated the influence of temperature on the pharmacokinetics and pharmacodynamics of vecuronium because mild core hypothermia doubles its duration of action. Methods Anesthesia was induced with alfentanil and propofol and maintained with nitrous oxide and isoflurane in 12 healthy volunteers. Train-of-four stimuli were applied to the ulnar nerve, and the mechanical response of the adductor pollicis was measured. Volunteers were actively cooled or warmed until their distal esophageal temperatures were in one of four ranges: &lt; 35.0 degrees C, 35.0-35.9 degrees C, 3

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12

&NA;. "Vecuronium bromide." Reactions Weekly &NA;, no. 1389 (2012): 42. http://dx.doi.org/10.2165/00128415-201213890-00154.

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13

&NA;. "Vecuronium bromide." Reactions Weekly &NA;, no. 1395 (2012): 41. http://dx.doi.org/10.2165/00128415-201213950-00142.

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14

&NA;. "Vecuronium bromide." Reactions Weekly &NA;, no. 1191 (2008): 25. http://dx.doi.org/10.2165/00128415-200811910-00081.

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15

&NA;. "Vecuronium bromide." Reactions Weekly &NA;, no. 1370 (2011): 37. http://dx.doi.org/10.2165/00128415-201113700-00129.

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16

&NA;. "Vecuronium bromide." Reactions Weekly &NA;, no. 599 (1996): 11. http://dx.doi.org/10.2165/00128415-199605990-00039.

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17

&NA;. "Vecuronium bromide." Reactions Weekly &NA;, no. 621 (1996): 12. http://dx.doi.org/10.2165/00128415-199606210-00039.

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18

&NA;. "Vecuronium bromide." Reactions Weekly &NA;, no. 371 (1991): 12. http://dx.doi.org/10.2165/00128415-199103710-00065.

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19

&NA;. "Vecuronium bromide." Reactions Weekly &NA;, no. 395 (1992): 12. http://dx.doi.org/10.2165/00128415-199203950-00057.

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20

&NA;. "Vecuronium bromide." Reactions Weekly &NA;, no. 408 (1992): 12. http://dx.doi.org/10.2165/00128415-199204080-00050.

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21

&NA;. "Vecuronium bromide." Reactions Weekly &NA;, no. 416 (1992): 12. http://dx.doi.org/10.2165/00128415-199204160-00055.

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22

&NA;. "Vecuronium bromide." Reactions Weekly &NA;, no. 421 (1992): 12. http://dx.doi.org/10.2165/00128415-199204210-00057.

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23

&NA;. "Vecuronium bromide." Reactions Weekly &NA;, no. 299 (1990): 11. http://dx.doi.org/10.2165/00128415-199002990-00054.

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24

&NA;. "Vecuronium bromide." Reactions Weekly &NA;, no. 300 (1990): 12. http://dx.doi.org/10.2165/00128415-199003000-00049.

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25

&NA;. "Vecuronium bromide." Reactions Weekly &NA;, no. 304 (1990): 12. http://dx.doi.org/10.2165/00128415-199003040-00052.

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26

&NA;. "Vecuronium bromide." Reactions Weekly &NA;, no. 331 (1990): 11. http://dx.doi.org/10.2165/00128415-199003310-00061.

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27

&NA;. "Vecuronium bromide." Reactions Weekly &NA;, no. 332 (1990): 8. http://dx.doi.org/10.2165/00128415-199003320-00043.

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28

&NA;. "Vecuronium bromide." Reactions Weekly &NA;, no. 336 (1991): 8. http://dx.doi.org/10.2165/00128415-199103360-00039.

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29

&NA;. "Vecuronium bromide." Reactions Weekly &NA;, no. 1016 (2004): 18. http://dx.doi.org/10.2165/00128415-200410160-00061.

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30

&NA;. "Vecuronium bromide." Reactions Weekly &NA;, no. 507 (1994): 16. http://dx.doi.org/10.2165/00128415-199405070-00080.

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31

&NA;. "Vecuronium bromide." Reactions Weekly &NA;, no. 1420 (2012): 50. http://dx.doi.org/10.2165/00128415-201214200-00173.

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32

&NA;. "Vecuronium bromide." Reactions Weekly &NA;, no. 1429 (2012): 44. http://dx.doi.org/10.2165/00128415-201214290-00168.

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33

Ploeger, Bart A., Jean Smeets, Ashley Strougo, et al. "Pharmacokinetic–Pharmacodynamic Model for the Reversal of Meeting Abstracts by Sugammadex." Anesthesiology 110, no. 1 (2009): 95–105. http://dx.doi.org/10.1097/aln.0b013e318190bc32.

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Background Sugammadex selectively binds steroidal neuromuscular blocking drugs, leading to reversal of neuromuscular blockade. The authors developed a pharmacokinetic-pharmacodynamic model for reversal of neuromuscular blockade by sugammadex, assuming that reversal results from a decrease of free drug in plasma and/or neuromuscular junction. The model was applied for predicting the interaction between sugammadex and rocuronium or vecuronium. Methods Noninstantaneous equilibrium of rocuronium-sugammadex complex formation was assumed in the pharmacokinetic-pharmacodynamic interaction model. The

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34

Warwick, Neil R., Garry G. Graham, and Thomas A. Torda. "Pharmacokinetic Analysis of the Effect of Vecuronium in Surgical Patients." Anesthesiology 88, no. 4 (1998): 874–84. http://dx.doi.org/10.1097/00000542-199804000-00005.

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Background Methods of the kinetic analysis of vecuronium based on effect only were developed but have been limited by the short time period of the studies. Using a multicompartment model and sequential dosing, the authors studied the ability of tests to determine most pharmacokinetic and pharmacodynamic parameters of vecuronium without measuring plasma concentrations. Methods The time course of neuromuscular blockade by successive bolus doses of vecuronium was recorded using electromyography. Inhibition of neuromuscular transmission by vecuronium was modeled by a biexponential decline in the c

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35

Teviotdale, B. M. "Vecuronium-Thiopentone Induction for Emergency Caesarean Section under General Anaesthesia." Anaesthesia and Intensive Care 21, no. 3 (1993): 288–91. http://dx.doi.org/10.1177/0310057x9302100305.

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Induction of general anaesthesia for emergency caesarean section has always been hazardous. Acid aspiration syndrome1 and adverse reactions to suxamethonium1- are well recognised problems, in spite of which “crash” induction using thiopentone and suxamethonium remains a common induction technique.4 Recent case reports-1 suggest that the use of medium duration nondepolarising relaxants in place of suxamethonium achieves satisfactory intubating conditions in the emergency caesarean section patient. This study was undertaken to investigate the following aspects of rapid-sequence vecuronium-thiope

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36

Ririe, Douglas G., Frederic Shapiro, and Navil F. Sethna. "The Response of Patients with Duchenne's Muscular Dystrophy to Meeting Abstracts with Vecuronium." Anesthesiology 88, no. 2 (1998): 351–54. http://dx.doi.org/10.1097/00000542-199802000-00013.

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Background The authors hypothesized that patients with Duchenne's muscular dystrophy (DMD) are more sensitive to nondepolarizing muscle relaxants. Methods Eight children with DMD and eight healthy children having orthopedic procedures were studied. Anesthesia consisted of thiopental, 60% nitrous oxide in 40% oxygen, and intravenous fentanyl and midazolam. Using electromyography, the ulnar nerve was stimulated and the electromyographic train-of-four ratio (TOFr) of the first dorsal interosseous muscle was recorded every 60 s. After baseline TOFr recording, all patients received 50 microg/kg vec

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37

Suy, Koen, Karl Morias, Guy Cammu, et al. "Effective Reversal of Moderate Rocuronium- or Vecuronium-induced Neuromuscular Block with Sugammadex, a Selective Relaxant Binding Agent." Anesthesiology 106, no. 2 (2007): 283–88. http://dx.doi.org/10.1097/00000542-200702000-00016.

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Background Sugammadex rapidly reverses rocuronium-induced neuromuscular block. This study explored the dose-response relation of sugammadex given as a reversal agent at reappearance of the second muscle twitch after rocuronium- and vecuronium-induced block. A secondary objective was to investigate the safety of single doses of sugammadex. Methods In this two-center, phase II, dose-finding study, 80 patients (age &gt;or= 18 yr, American Society of Anesthesiologists physical status I or II, surgery &gt;or= 60 min requiring muscle relaxation for intubation) were randomly assigned to recei

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38

Teitelbaum, J., C. O. Borel, S. Magder, R. J. Traystman, and S. N. Hussain. "Effect of selective diaphragmatic paralysis on the inspiratory motor drive." Journal of Applied Physiology 74, no. 5 (1993): 2261–68. http://dx.doi.org/10.1152/jappl.1993.74.5.2261.

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Using alpha-chloralose-anesthetized mechanically ventilated vagotomized dogs, we assessed the effects of selective diaphragmatic paralysis on the inspiratory motor drive. Diaphragmatic paralysis was accomplished by a bolus injection of vecuronium, a neuromuscular junction blocker, into the left phrenic artery of an in situ vascularly isolated and innervated left diaphragm. The inspiratory motor drive during spontaneous breathing attempts was assessed by measuring peak integrated electromyographic (EMG) activities of the left and right diaphragms and parasternal and alae nasi muscles. Respirato

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39

King, Melinda, Nuntiya Sujirattanawimol, David R. Danielson, Brian A. Hall, Darrell R. Schroeder, and David O. Warner. "Requirements for Muscle Relaxants during Radical Retropubic Prostatectomy." Anesthesiology 93, no. 6 (2000): 1392–97. http://dx.doi.org/10.1097/00000542-200012000-00008.

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Background The need for the routine use of muscle relaxants to provide an adequate surgical field for intraabdominal surgery has not been established. This study tested the hypothesis that vecuronium decreases the frequency of unacceptable operating conditions for patients undergoing radical retropubic prostatectomy who are anesthetized with isoflurane and fentanyl. Methods After obtaining informed consent, patients in this blinded, placebo-controlled study were randomized to receive either an infusion of vecuronium or saline (placebo) beginning 5 min after fascial incision during the maintena

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40

&NA;. "Corticosteroids/vecuronium bromide." Reactions Weekly &NA;, no. 1389 (2012): 19. http://dx.doi.org/10.2165/00128415-201213890-00063.

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41

&NA;. "Sevoflurane/vecuronium bromide." Reactions Weekly &NA;, no. 1369 (2011): 34. http://dx.doi.org/10.2165/00128415-201113690-00122.

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42

&NA;. "Isoflurane/vecuronium bromide." Reactions Weekly &NA;, no. 439 (1993): 10. http://dx.doi.org/10.2165/00128415-199304390-00048.

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43

&NA;. "Vecuronium bromide interaction." Reactions Weekly &NA;, no. 619 (1996): 12. http://dx.doi.org/10.2165/00128415-199606190-00035.

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44

&NA;. "Vecuronium/pancuronium/metocurine." Reactions Weekly &NA;, no. 381 (1991): 12. http://dx.doi.org/10.2165/00128415-199103810-00065.

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45

&NA;. "Anaesthetics/vecuronium bromide." Reactions Weekly &NA;, no. 1105 (2006): 5. http://dx.doi.org/10.2165/00128415-200611050-00010.

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46

&NA;. "Anaesthetics/vecuronium bromide." Reactions Weekly &NA;, no. 1235 (2009): 7. http://dx.doi.org/10.2165/00128415-200912350-00019.

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47

&NA;. "Vecuronium bromide interaction." Reactions Weekly &NA;, no. 326 (1990): 11. http://dx.doi.org/10.2165/00128415-199003260-00060.

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48

&NA;. "Vecuronium bromide overdose." Reactions Weekly &NA;, no. 334 (1991): 11. http://dx.doi.org/10.2165/00128415-199103340-00075.

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49

&NA;. "Vecuronium bromide interaction." Reactions Weekly &NA;, no. 355 (1991): 12. http://dx.doi.org/10.2165/00128415-199103550-00072.

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50

Scott, R. P. F. "Recurarisation after vecuronium?" Anaesthesia 43, no. 2 (2007): 165. http://dx.doi.org/10.1111/j.1365-2044.1988.tb05510.x.

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