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E.P., Gorbaneva, Lifanova E.V., Mitsulina M.P., Bakulin V.S., and Ryabchuk Yu.V. "SYNDROME OF VEGETATIVE DYSFUNCTION AMONG YOUNG STUDENTS IN VOLGOGRAD EDUCATIONAL INSTITUTIONS." “Educational bulletin “Consciousness” 24, no. 2 (February 25, 2022): 22–29. http://dx.doi.org/10.26787/nydha-2686-6846-2022-24-2-22-29.
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The syndrome of autonomic dysfunction (SVD) is interpreted as a set of polysystemic disorders caused by disorders of the higher autonomic centers. Today, the number of young people who report symptoms of this dysfunction continues to increase. Thus, a significant proportion of students with SVD are at risk of developing abnormalities in their health state, due to dysregulation of vascular tone, aggravated by desynchronosis. The aim of the study studied the incidence of autonomic dysfunction syndrome among students in Volgograd educational institutions. The survey included the study of the state of balance of the autonomic nervous system using the Wayne questionnaire, as well as chronotypes using the Horn-Ostberg test. The results were processed using the methods of mathematical statistics. Installed, it was found that the highest prevalence of vegetative-vascular dystonia (VVD) is among the student youth of the Volgograd region. Among female representatives, VVD is found somewhat more often than among men. Representatives of the owners of arrhythmic and weak evening chronotypes are more susceptible to the development of autonomic dysfunctions. Systematic muscular activity is a limiting factor in the progression of the syndrome of vegetative-vascular dysfunctions. In order to preserve and improve the level of health of students actually is systematic observance of the motor activity, as well as the development of complex programs of physical education, taking into account individual daily biorhythms. Specified recommendations have a preventive focus in regard to the syndrome of autonomic dysfunction and its transformation into the pathology of a particular body system.
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Buryak, Vladimir N., Natalia S. Zhuravleva, and Oksana S. Pokusaeva. "Features of the initial vegetative tone and vegetative reactivity in vegetative-vascular dysfunction of the hypotensive type in childhood." Pediatrician (St. Petersburg) 9, no. 2 (May 15, 2018): 41–48. http://dx.doi.org/10.17816/ped9241-48.
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VVD hypotensive type significantly reduces the quality of life, prevents normal growth and differentiation of organs and tissues of the child’s body, promotes the formation of a number of life-threatening pathological processes in adulthood. In order to determine the initial vegetative tonus in 63 children aged 11-14 years suffering from hypotensive type VVD, the averaged values of cardiointervalograms consisting of 100 consecutive cardiocycles were determined. Vegetative reactivity has been studied through the conduct and evaluation of a clinoortostatic test, consisting in the sequential recording of blood pressure and cardiograms first in a horizontal and then in an upright position. As a control group, 27 practically healthy peers were examined, who underwent a similar complex of clinical, laboratory and instrumental studies. Statistical processing of the obtained results was carried out by parametric and nonparametric methods with the help of STATISTICA and Microsoft Excel for Windows packages on the IBM “Pentium 166” computer. As a result of the study, a significant difference in vegetative tone was found in children with hypotensive VVD from normal. In this case, vegetative status is characterized either by the initial high level of functioning of sympathoadrenal regulatory mechanisms with insufficient increase in their adaptive activity or by the predominance of the initial cholinergic vegetative tension and the corresponding hypersympathicotonic reactivity, which is the marker of the greatest threat of transformation in this group of children of the hypersensitive type to the hypertensive and then into hypertensive disease.
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Sokolenko, V. L., and S. V. Sokolenko. "Manifestations of allostatic load in residents of radiation contaminated areas aged 18–24 years." Regulatory Mechanisms in Biosystems 10, no. 4 (October 3, 2019): 422–31. http://dx.doi.org/10.15421/021963.
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We studied the features of allostatic load (AL) in 100 students aged 18–24 years old who, from birth to adulthood, lived in the territories assigned to the IV radiation zone after the Chornobyl accident (density of soil contamination by isotopes 137Cs 3.7–18.5∙104 Bq/m2) and underwent prolonged exposure to small doses of ionizing radiation. The examined students did not have any clinical signs of the immune-neuroendocrine system dysfunction. 50 people had signs of vegetative-vascular dystonia syndrome (VVD), 48 had signs of moderate hyperthyroidism and 21 had signs of moderate hypothyroidism. During the examination session, as a factor of additional psycho-emotional load, in 66 of the examined the immunoregulatory index CD4+/CD8+ went below the lower limit of the homeostatic norm, in 62 of the examined low density lipoprotein cholesterol (LDL-C) exceeded the upper level. The relative risk (RR) and attributable risk (AR) of the participation of potential secondary factors of allostatic load formation in CD4+/CD8+ immunoregulatory index going below the lower limit were calculated. The presence of statistically significant relative risk of participation in the formation of suppression of the index CD4+/CD8+: the state of hyperthyroidism, state of hypothyroidism, vegetative-vascular dystonia syndrome, higher than normal LDL-C. When the examined students combined the signs of hyperthyroidism, vegetative-vascular dystonia syndrome and higher level of LDL-C; with combination of signs of hypothyroidism, vegetative-vascular dystonia syndrome and higher level of LDL-C. The attributable risk in all cases exceeded 0.10, which confirmed the importance of some of these factors and their complexes in the formation of the effect of reduced immunoregulatory index. The CD4+/CD8+ index can be considered an important biomarker of AL and premature age-related changes in the immune system in residents of radiation-contaminated areas. The risk of AL formation in the case of occurrence of a complex of mediated secondary biomarkers (vegetative-vascular dystonia syndrome, thyroid dysfunction, hypercholesterolemia) is higher compared to their individual significance.
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Cherednichenko, T., V. Sereda, N. Svyrydova, T. Parnikoza, G. Chuprina, N. Khanenko, R. Sulik, O. Mykytei, and V. Svystun. "Vegetative-vascular dystonia: etiopathogenesis, clinical picture, diagnosis, treatment (clinical lecture)." East European Journal of Neurology, no. 1(13) (March 20, 2017): 34–39. http://dx.doi.org/10.33444/2411-5797.2017.1(13).34-39.
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This article discusses the clinical lecture on the problem of terminology, etiology and pathogenesis, diagnosis and treatment of vegetative dystonia. Also featuring a modern classification of autonomic disorders, are the criteria for the differential diagnosis of autonomic crises. Given the urgency of the problem in the structure of autonomic disorders of neurological diseases, the focus of the lecture material placed on pathogenetically justified therapeutic measures. The manifestations of dysregulation manifest as dysfunction of the endocrine, simpatoadrenalovoj and cholinergic systems, disorders of water and salt, and acid-base status, oxygen supply of physical activity, the oxygen reduction in the tissues, which leads to activation of metabolic disorders, microcirculation with the development of pathological processes in the myocardium and the emergence of hypertension. Therefore, expansion of clinical and diagnostic indicators in preparation for the lecture topics will contribute to a more effective professional development specialists.
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Kulikova, Natalya G., Tatyana V. Konchugova, Inna V. Volkova, and Albina S. Tkachenko. "Vegetative Indices in Assessing Effectiveness of the Photobioacoustic Complex in Children with the Vegetative Nervous System Somatoform Dysfunction, often Suffering from Acute Recurrent Infections." Bulletin of Rehabilitation Medicine 20, no. 4 (August 31, 2021): 65–71. http://dx.doi.org/10.38025/2078-1962-2021-20-4-65-71.
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Photobioacoustic methods of complex exposure allow correcting vegetative, vascular-cardiac disorders in children with autonomicnervous system somatoform dysfunction syndrome (ANSSDS) without pharmacological load. Aim. To optimize the treatment of children with somatoform vegetative dysfunction (ANSSDS), often suffering from recurrent infections,using physiotherapy methods.The aim of the study was to optimize the treatment of children with somatoform vegetativedysfunction, often suffering from recurrentinfections, using physiotherapy methods. Material and methods. The study included 140 children with autonomic nervous system somatoform dysfunction syndrome (ANSSDS),often suffering from recurrent infection. For the first time, clinical complaints, functional (ECG and cardiointerval recording KIR)and vegetative indicators (Kerdo, Hildebrandt index, Biend, Baoev-Parin) before/after application of the innovative photobioacousticcomplex, including: BАС-BFB-bioacoustic effects on the head and LLLR on the projection of the cubital region and thymus were analyzed.The duration of the procedure was 30 minutes and the course of treatment was 10 procedures. Before and after the procedures,vegetative indices and indicators of myocardial bioelectrogenesis were examined, comparing them with the norm in healthy children. Results. 35% of children were diagnosed with parasympathicotonia (sympathetic imbalance -SI); 54.1% – sympathetic (SA) and10.9% – mixed (etonia – E) type of vegetative dystonia. There were reveled gender-age differences in subjective complaints of childrenwith ANSSDS, whose index vegetative indicators were correlated with the type of vegetative support. Children with SA were 2.5 timesmore likely to be diagnosed with cardiac syndrome and elevated blood pressure; in children with SI – 3.5 times more often detected:gastric, astheenoeurotic syndrome and allergic diseases; in children with E: asthenonevrotic, neurosis-like disorders and sleep disturbancesthat were differentiated after the use of photobioacoustic complex. Complaints and vegetative indices in children with SI andE were corrected more significantly than in SA. Conclusion. Evaluation of vegetative indicators in children 7-12 years with ANSSDS, often suffering from recurrent infection, allows topersonify treatment programs and reduce the level of acute recurrent morbidity by 2.5 times.
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Marushko, Yu V. "The Role and Place of Magnesium Deficiency in the Development of Vegetative-Vascular Dysfunction in Children." CHILD`S HEALTH, no. 4.72 (July 13, 2016): 43. http://dx.doi.org/10.22141/2224-0551.4.72.2016.76588.
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Butcher, Jonathan T., and Robert M. Nerem. "Valvular endothelial cells and the mechanoregulation of valvular pathology." Philosophical Transactions of the Royal Society B: Biological Sciences 362, no. 1484 (June 14, 2007): 1445–57. http://dx.doi.org/10.1098/rstb.2007.2127.
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Endothelial cells are critical mediators of haemodynamic forces and as such are important foci for initiation of vascular pathology. Valvular leaflets are also lined with endothelial cells, though a similar role in mechanosensing has not been demonstrated. Recent evidence has shown that valvular endothelial cells respond morphologically to shear stress, and several studies have implicated valvular endothelial dysfunction in the pathogenesis of disease. This review seeks to combine what is known about vascular and valvular haemodynamics, endothelial response to mechanical stimuli and the pathogenesis of valvular diseases to form a hypothesis as to how mechanical stimuli can initiate valvular endothelial dysfunction and disease progression. From this analysis, it appears that inflow surface-related bacterial/thrombotic vegetative endocarditis is a high shear-driven endothelial denudation phenomenon, while the outflow surface with its related calcific/atherosclerotic degeneration is a low/oscillatory shear-driven endothelial activation phenomenon. Further understanding of these mechanisms may help lead to earlier diagnostic tools and therapeutic strategies.
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Ahkubekova, Nelly K., Anatoly T. Tereshin, and Angela E. Bestaeva. "Correction of psychoemotional and vascular-autonomic dysfunction with patients suffering from endometrial disease under the influence of complex radon, laser, and drug treatment." Russian Journal of Physiotherapy, Balneology and Rehabilitation 18, no. 3 (March 8, 2021): 161–65. http://dx.doi.org/10.17816/1681-3456-2019-18-3-161-165.
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The research objective is to develop a program to correct psycho-emotional and vascular-autonomic dysfunction with patients suffering from adenomyosis using complex radon, laser and drug treatment.
Material and methods. There were 100 women with adenomyosis complicated by psycho-emotional and vascular-autonomic dysfunction from the age of 23 up to 37 years old who underwent treatment at a branch of Pyatigorsk Clinic of North Caucasian Federal Scientific and Clinical Centre of Federal Medical and Biological Agency of Russia. The patients were divided into 2 groups by a randomized method: the main group received radon, laser and drug therapy with Melaxen, the group of comparison received radon and laser therapy.
Results. A comparative analysis showed the expediency of including adaptogens in the complex of sanatorium-and-spa treatment of patients with endometrial disease: the improvement of clinical symptoms in the main group compared to the group of comparison was more frequent by 1.36 times; normalization of vegetative management in the main group occurred with 72% of the patients compared to 52% in the group of comparison; in the main group the decrease in the intensity of anxious disorders was 2.64 times (p 0.01), against 1.46 times in the group of comparison (p 0.05); normalization of concentration of peptide and steroid hormones in blood serum in the main group was with 64% of the patients versus 42% in the group of comparison.
Conclusion. Inclusion of Melaxen in the complex of traditional sanatorium-and-spa treatment of patients with adenomyosis (radon and laser therapy) provides significant improvement of neuroendocrine system, psycho-emotional, vegetative-vascular status.
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Дмитриенко, G. Dmitrienko, Баисова, E. Baisova, Череващенко, and Lyubov Cherevashchenko. "Acupuncture and phototherapy efficiency for correction оf erectile dysfunction in the patients with neurotic depression." Journal of New Medical Technologies. eJournal 8, no. 1 (November 5, 2014): 0. http://dx.doi.org/10.12737/6446.
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Sexual dysfunction in men, limiting their reproductive capabilities, prevent the achievement of marital and sexual life as a couple, break the stability of marriage, adversely affect mental health, lead to the development of neurotic and depressive disorders, alcohol abuse and antisocial behaviour.
In recent years, interest in the problem of vasculogenic erectile dysfunction has increased worldwide. But, despite this, many researchers believe that erectile dysfunction of vascular origin ranks second in frequency after disorders due to psychogenic factors.
Therapy of sexual disorders with neurotic depression has a number of obstacles due to absence of system-structural approach to sexopathologist syndromes. It is necessary to search new possibilities of correction of sexual disorders in patients with neurotic depression.
The purpose of this study was to develop and to justify pathogenetically the method of combined use of phototherapy and acupuncture for the correction of sexual disorders to improve the effect of treatment in men with neurotic depression.
80 patients with neurotic depression and erectile dysfunction prior to the application of medical facilities and at the end of treatment were examined. The results of treatment were: restoration of sexual function, decrease or disappearance of neurasthenic complaints (irritability, fatigue, headaches, dyssomnia, psycho-emotional, vegetative-vascular disorders, and others), normalization of libido and paraclinical data (psychological testing, electrophysiological parameters).
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Yusufov, A. A., I. A. Cherkasova, E. A. Lavrova, and A. A. Plyukhin. "Cardiac and Visceral Signs of Connective Tissue Dysplasia in Children with Juvenile Rheumatoid Arthritis According to Ultrasound Examination Data." Radiology - Practice, no. 5 (November 2, 2021): 91–98. http://dx.doi.org/10.52560/2713-0118-2021-5-91-98.
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To study the cardiac and visceral signs of connective tissue dysplasia in children with juvenile rheumatoid arthritis, a comprehensive ultrasound examination of the abdominal cavity organs and echocardiography examination were conducted according to the standard protocol in 52 children aged from 5 to 16 years with the diagnosis of juvenile rheumatoid arthritis. The reference group consisted of 26 patients with autonomic dysfunction (vegetative-vascular dystonia). The incidence of such visceral dysplasia types as duodenogastric reflux, gastroesophageal reflux, and gallbladder malformations among children with juvenile rheumatoid arthritis was shown higher than in the reference group. The main cardiac sign of connective tissue dysplasia in patients with juvenile rheumatoid arthritis are an excessive chord of the left ventricle.
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Loshakova, A. I., O. N. Brazhenko, N. A. Brazhenko, S. G. Zheleznyak, and N. V. Tsygan. "Functional state of the autonomic nervous system, adaptation, homeostasis and reactivity of the organism in the clinic of tuberculosis and sarcoidosis." Bulletin of the Russian Military Medical Academy 20, no. 2 (December 15, 2018): 244–48. http://dx.doi.org/10.17816/brmma12363.
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In recent decades, the shift in priority in the treatment of patients with pulmonary granulomatosis in the direction of etiotropic therapy and reduced attention to the state of the macroorganism led to a decrease in the effectiveness of treatment. In modern conditions, when carrying out complex therapy for patients with tuberculosis and sarcoidosis, insufficient attention is paid to the state and dynamics of adaptation, resistance, homeostasis and reactivity of the organism. At the same time, the dynamics of these processes in patients is insignificant, the homeostatic balance of the organism is not restored, and the reactivity of the organism remains at the pathological level, with the predominance of paradoxical, hyporeactive and areactive types. This is due to the continuing influence on the regulatory centers of the vegetative system of not diagnosed, latent, ongoing tuberculosis intoxication. Undetected specific intoxication causes in patients activation of the sympathetic department, suppression of parasympathetic and development of dysfunction of the autonomic nervous system. Its dysfunction leads to a decrease in vascular supply of the organism, a high tension of anabolic processes, and a further change in the functional activity of both parts of this system when pathology develops. In addition, the emergence of vegetative dysfunction leads to a high consumption of plastic materials, energy resources, a decrease in the functional reserves of the body, a decrease and depletion of the body’s defense systems, its anti-inflammatory potential and the reactivity of the organism as a whole. These changes lead to an extension of the main course of treatment and the formation of expressed residual tubercular and sarcoidosis in the respiratory organs. To restore these disorders, it is necessary to carry out complex therapy with the inclusion of a personified appointment of activators of protective systems under the control of monitoring their effectiveness.
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Ustinova, Olga Yu, Vitaly G. Kostarev, Vadim B. Alekseev, Elena M. Vlasova, Aleksandr E. Nosov, Artem V. Zaitsev, and Lev Yu Levin. "The impact of working conditions on the functional state of employes in thermoshaft oil production." Hygiene and sanitation 99, no. 11 (December 22, 2020): 1222–29. http://dx.doi.org/10.47470/0016-9900-2020-99-11-1222-1229.
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The aim of the study was to assess the functional state of the autonomic nervous and cardiovascular systems of workers employed at the thermoshaft oil production. material and methods. Our test group No. 1 was consisted of operators dealing with blowing of wells. Their average age accounted of 30.5 ± 5.1 years; average underground experience amounted to 6.5 ± 2.7 years. Our test group No. 2 included 20 workers who performed their working tasks only on the surface but who had had the underground experience in the past. Their average age was 39.8±6.4 years (p>0.05); average surface experience amounted to 6.4±3.1 years (p>0.05), underground experience - 7.9±2.3 years (p>0.05). Our reference group consisted of 23 office workers never exposed to any adverse occupational factors. Their average age was 31.3±4.6 (p>0.05); average working experience amounted to 6.5±3.4 years (p>0.05). Our research analyzed non-occupational and occupational risk factors, neurophysiologic testing, the examination of vegetative functions, and statistic data processing. Results. 88% of workers in the test group No. 1 had “vegetative” complaints, whereas only 13% had apparent symptoms related to such disorders. Clinical examinations revealed vegetative dysfunction signs in 100% workers in the test group No. 1; in 62% workers in the test group No. 2 (t>2, p<0.05,χ2=10.1); and only in 29% workers in the reference group (t>2, p<0.05, χ2=23.9). Neurophysiologic testing allowed revealing workers from the test group No.1 to show attention decrement and an increase in the speed of mental responses by the end of their work shift. 24% had increased blood pressure, both systolic (up to 152.3±8.4 mm Hg) and diastolic one (up to 87.4±13.7 mm Hg). The absolute risk for workers from the test group No. 1 amounted to 0.8 as per detected functional disorders. It amounted to only 0.2 for workers never exposed to adverse occupational factors. Conclusion. Occupational activities performed by workers employed at thermoshaft oil production result in chronic fatigue. Neuropsychological and physical overloads lead to a decline in adaptation reserves of a body, vegetative disorders, and vascular tone dysfunction, which may be the arterial hypertension predictor.
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Shkala, Liubov, and Oleh Shkala. "The Spread of Thyroid Diseases and the Algorithm for Diagnosing Thyroid Dysfunction." Family Medicine, no. 1 (March 31, 2021): 32–38. http://dx.doi.org/10.30841/2307-5112.1.2021.231926.
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Diseases of the thyroid gland are considered one of the most common endocrinopathies. This is due to the influence of ecologically unfavorable environmental factors, bad habits, malnutrition, comorbid conditions and genetic predisposition. Determining an algorithm for diagnosing thyroid dysfunction for the timely detection of diseases is expedient and relevant. The objective: to analyze the state of the spread of thyroid diseases among the population of the Kiev region and to determine the diagnostic algorithm based on the identification of the main clinical syndromes of thyroid dysfunction. Materials and methods. Among the adult population of the Kiev region, a high level of morbidity and spread of thyroid diseases is recorded. The increase in the number of cases occurred, first of all, due to the newly diagnosed patients with hypothyroidism, thyroiditis. The manifestation of most diseases is associated with the development of thyroid dysfunction. Under the hypothyroidism one can observe and diagnose the following: a syndrome of neuropsychiatric disorders with slowing down of motor activity, decrease in cognitive functions; syndrome of vegetative-trophic disorders with cutaneous mucinosis, polyneuropathy; syndrome of cardiovascular changes with decreased myocardial contractility, slow blood flow, progressive development of atherosclerosis; anemic syndrome; digestive tract syndrome with impaired motor and secretory functions of the gastrointestinal tract; syndrome of hormonal disorders with decreased secretion of thyroid hormones, especially T4, increased levels of TSH (in primary hypothyroidism) or decreased TSH (in secondary and tertiary). Results. Thyrotoxicosis in patients is determined by an enlarged thyroid gland with the development of: thyrotoxic cardiomyopathy and systolic arterial hypertension; thyrotoxic encephalopathy, syndrome of neuropsychiatric disorders with a predominance of excitation processes, vascular dysfunction; thyrotoxic ophthalmopathy, ectodermal disorders syndrome along with a decrease in TSH production and an increase in the level of free fractions T4, T3. Conclusions. The algorithm for diagnosing hypofunction and hyperfunction of the thyroid gland provides for: clarification of complaints and anamnesis data, examination of the patient, additional laboratory and instrumental examination, which includes the study of the thyroid status, possible autoaggression, analysis of metabolic processes, assessment of pathomorphological changes in the thyroid gland.
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Golubev, Yu Yu, A. E. Lychkova, A. E. Severin, V. I. Torshin, Yu P. Starshinov, G. Yu Golubeva, N. G. Samsonova, and A. M. Puzikov. "Somatoform disorders in the development of visceral systems pathology." Experimental and Clinical Gastroenterology, no. 12 (December 20, 2019): 40–50. http://dx.doi.org/10.31146/1682-8658-ecg-172-12-40-50.
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Introduction. Somatoform disorder (vegetative dysfunction), which occurs against the background of endocrine changes in the body during adolescence, is clinically inadequate vegetative regulation. Up to 50 percent of patients with primary care have physical symptoms that can not be explained by the general health status. In recent years, much attention has been paid to the problem of somatoform disorders in hypertension, chronic heart failure (CHF). There is a high prevalence of anxiety-depressive disorders, especially in patients with CHF. Unexplained symptoms of somatoform disorders often lead to more frequent visits to doctors, unnecessary visits to the clinic and laboratory tests or costly and potentially dangerous invasive procedures. The aim is to study autonomic dysfunction in patients with chronic heart failure and anxiety-depressive disorders and electrophysiological aspects of somatization of pathology in irritable bowel syndrome (IBS). Material and methods. The study was conducted in 35 patients with somatoform disorders in irritable bowel syndrome accompanied by severe abdominal pain. The study involved 25 patients with a functional class of chronic heart failure (CHF) NYHA II-III against a background of arterial hypertension (AH) of ischemic origin and 30 patients with arterial hypertension of II degree and abdominal obesity (AO). Results. All patients showed signs of anxiety-depressive or somatoform disorders, asthenia. The presence of signs of anxiety and depressive disorders in patients with CHF and AH was accompanied by violations of autonomic regulation of blood pressure level, activity of the sympathetic nervous system, frequent occurrence of cardiac arrhythmias, decreased tolerance to physical activity and deterioration of the quality of life of this category of patients. The IBS was studied by electromyography. In the descending part of the colon, an increase in the frequency and amplitude of slow waves was observed, and the power of contraction was increased to 3 times. Conclusions. Imbalance of the sympathetic / parasympathetic systems in favor of the sympathetic part of the ANS contributes to worsening of the compromised function of the vascular endothelium. These changes significantly increase the risk of developing a lethal outcome of acute myocardial infarction. The high prevalence and the associated increase in morbidity and mortality make it necessary to continue research into the regulation of regulation of somatoform disorders in chronic heart failure.
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Vorobieva, Viktoriya V., Ol’ga S. Levchenkova, and Petr D. Shabanov. "Pathophysiological mechanisms of neurological disorders in experimental animals exposed to vibration." Reviews on Clinical Pharmacology and Drug Therapy 18, no. 3 (October 14, 2020): 213–24. http://dx.doi.org/10.17816/rcf183213-224.
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The review presents an analysis of literature on the study of nervous system changes in experimental animals exposed to vibration. The hypoxic type of cellular metabolism against the background of vibration is the result of vascular mechanoreceptors stimulation and spasm of blood vessels as well as intravascular pressure phase fluctuations and impaired blood and lymph outflow. Hemodynamic disorders and microangiopathy in the central nervous system can reach the level of cerebral vascular impairment and capillary-trophic insufficiency of the brain. Changes in calcium homeostasis at the cellular and tissue levels is a key mechanism of neuronal destruction occurring alongside with impaired blood supply to the nervous tissue in patients with vibrational disease. Long-term exposure to vibration results in reduced tissue respiration in the brain structures of experimental animals, that is most pronounced in the cortex and leads to a pathological change of spontaneous electrical activity of brain structures. Acute vibration stress stimulated the synthesis and excretion of serotonin not only in the hippocampus and hypothalamus but also in the cerebellum, which explains the disturbances of the oculomotor reactions observed in vibration exposure in the control system of the vertical vestibular ocular reflex. A decrease in the total number of neurons as well as an increase in the number of astroglia cells against the background of paravascular tissue edema were revealed against the background of changes in neurotransmitters levels. An increase in the concentration of the biomarker of structural and functional damage to brain tissue specific protein S-100B accompanies the development of professional sensorineural hearing loss and dysfunction of cerebral level vegetative regulation.
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Chaulin, Aleksey, Artem Aleksandrov, Artem Sergeev, and Dmitry Duplyakov. "The Role of Fine Particles That Pollute Ambient Air In Atherosclerosis Pathogenesis: A Literature Review." Archiv Euromedica 11, no. 6 (December 12, 2021): 23–28. http://dx.doi.org/10.35630/2199-885x/2021/11/6.5.
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Background. Atmospheric air pollution with fine particles (PM 2.5) is one of the global challenges having an impact on the disease rate, mortality, and disability of the earth’s population. The optimal content of PM2.5 in the air is < 10 micrograms/m3 (according to WHO), however, this concentration is not completely safe. Currently the impact of fine particles that pollute ambient air on the progression of atherosclerosis and cardiovascular diseases (CVD) is being actively studied. Pathogenetic mechanisms enabling fine particles to partake in atherogenesis are being studied. Understanding specific fundamental mechanisms which underpin PM 2.5-induced atherogenesis allows to improve prevention-care intervention aimed to mitigate the negative impact of PM 2.5 on pathogeny of atherosclerosis and CVD. Objective. Study of the impact of fine particles polluting ambient air on the development and progression of atherosclerosis and CVD, as well as discussion of the main pathogenetic mechanisms that underpin this phenomenon. Methods. PubMed/Medline and Embase databases have been used for searching and analyzing modernday literature. We looked at the terms «fine particles», and «PM 2.5» in combination «atmospheric air» with «atherosclerosis». The search for literary sources has been carried out over the past 15 years. Results. Many experimental and clinical studies prove the connection between fine particles (PM 2.5) polluting ambient air and the risk of atherosclerosis progression and further CVD progression, all the way through to the increased risk of unfavorable cardiovascular events (acute myocardial infarction, cerebral vascular accidents) in persons inhabiting polluted areas. PM 2.5-induced atherosclerosis is underpinned by the following pathogenetic mechanisms: Induction of oxidative stress and enhancement of inflammatory reactions, progression of endothelial dysfunction, as well as dysfunction of vegetative nervous system, and imbalance of coagulative blood system.
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Kudinova, O. I. "Somatoform disorders psychotherapy correction." European Psychiatry 26, S2 (March 2011): 1570. http://dx.doi.org/10.1016/s0924-9338(11)73274-6.
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At the present time in Ukraine the special priority has the problem of somatoform disorders. A prevalence of clinical somatization neurotic disturbances and necessity of differential diagnostics with somatic diseases were the precondition for studying this area. At the same time, in Ukraine the diagnosis “Vegetative-vascular dystonia” which is ciphered G 90.8, according to ICD-10 instead of “Somatoform disoders” F40.0-F48 is used. It leads unreasonable treatment significant contingents of neurotic patients in neurological departments. On the basis of complex study 300 patients with somatoform disorders and 200 patients with chronic psychosomatic disease are conducted determination of structure and dynamic of somatoform disorders in general practice in Kharkiv-city. Clinic-epidemiological and clinic-statistical research allowed to define the structure of somatoform disorders in ambulatory-policlinic practice. Somatoform dysfunction of cardiovascular system has 60%, of gastrointestinal system 25%, urinal system 8,0%, other - 7%. On that ground has been developed complex differential system of medical- psychological and psychotherapy correction of somatoform disorders with the - 80% high efficasy. Our experience showed the necessity of the integrative models of psychotherapy provided, parted on stage. On the first stage - sedative-adapting the receptions of cognitive and suggestive psychotherapy are used. There is groupe therapy on second-main-stage. On the third stage-supportive-elements of the autogenic training mastered.
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Lymarenko, Maryna P., and Daria V. Iskovich. "Clinical and morphofunctional features of the cardiovascular system in children with remheld syndrome." Pediatrician (St. Petersburg) 11, no. 4 (December 8, 2020): 15–19. http://dx.doi.org/10.17816/ped11415-19.
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The article is devoted to an urgent problem of pediatrics Remheld syndrome. The aim of the present work was to study the clinical and morphofunctional features of the cardiovascular system in children with Remkhelds syndrome. 23children from 10 to 18 years old with Remkhelds syndrome were examined.Research methods.Study of blood biochemical parameters (MV-CPK, ASLO titer, C-reactive protein), identification of persistent viral infection markers, ECG, daily monitoring of ECG and blood pressure by Holter, echocardiography, ultrasound of the vessels of the head and neck, ultrasound of the thyroid gland, ultrasound organs of the gastrointestinal tract. In the anamnesis, 78,3% of children had chronic gastroduodenitis, 21,7% had gastroesophageal reflux disease, and 8,7% had a hiatal hernia. All patients complained of cardialgia, interruptions in the work of the heart, a feeling of lack of air, dizziness upon admission. The appearance of noted complaints was associated with eating.Results.A study of the state of the cardiovascular system showed the presence of sinus tachycardia in 60,9% of patients, sinus bradycardia in 34,8%, single supraventricular extrasystole in 13,0%, paroxysmal supraventricular tachycardia in 4,3%,and 4,3% autonomic sinus node dysfunction, in 13,0% congenital heart disease (patent ductus arteriosus, bicuspid aortic valve), in 8,7% mitral valve anterior prolapse, in 4,3% a patent foramen ovale, in 95,7% of children vegetative-vascular dysfunction.Conclusion.Children and adolescents with diseases of the gastrointestinal tract, when cardiac complaints appear, need an in-depth examination of the cardiovascular system.
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GAIFUTDINOV, R. T. "Cerebral microangiopathy (disease of small blood vessels) and age-related hypogonadism in men." Practical medicine 18, no. 6 (2020): 176–81. http://dx.doi.org/10.32000/2072-1757-2020-6-176-181.
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The review discusses the contribution of age-related male hypogonadism to the formation of cerebral microangiopathy (disease of small brain vessels) (CMA/SVD). The current explanation of the nature of CMA by an ischemic-hypoxic process, which is based on hypo- or hyperperfusion of the white matter of brain due to a complex of various causes, does not explain the etiopathogenesis of CMA. The article considers a violation of the neuroglyovascular connection, represented by a vessel, astrocytic glia, and a neuron, as the cause of SVD development. The main role in the CMA formation is assigned to endothelial dysfunction, all variants of which (vasomotor, thrombophilic, adhesive, angiogenic) can be traced in SVD. The role of disorders of the main functions of arterial vessels — conducting and damping, as well as liquorodynamics disorders in the CMA pathogenesis is discussed. The data indicating the involvement of testosterone and its derivatives in the formation of cerebral vascular pathology are presented. It is emphasized that this participation can be of one kind in men with early physiological uncomplicated hypogonadism, when the hypothalamic-pituitary system is involved in the process, and of another kind in complicated or late climax. At that, an increase in the production of gonadotropin — releasing hormone (GnRH), the content of FSH and LH in peripheral blood is considered as a reaction to an age-related decrease in androgen function, and the vegetative dysfunction, metabolic and other disorders inherent in this period of life – as a result of changes in the functioning of the entire hypothalamus-pituitary-testicular axis. In complicated age-related hypogonadism, the resulting endocrine or somatic pathology is included in the process of small vessel disease formation. In late hypogonadism, the androgen function fades, and the hypothalamic-pituitary system begins to function in a different mode. Often, the clinic and mechanism of CMA formation are determined by diseases inherent in old age. The differences in the pathogenetic mechanisms of CMA development at various periods of IgG determine the need for a differentiated approach to the preventive means and methods of CMA therapy in men of the involutional period. The presented information may be useful for better understanding of CMA development in individuals with age-related hypogonadism.
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Anfilova, M. R. "Rosacea — modern features of pathogenesis and the possibility of drug correction in the era of growing antibiotic resistance." Ukrainian Journal of Dermatology, Venerology, Cosmetology, no. 1 (March 30, 2021): 39–44. http://dx.doi.org/10.30978/ujdvk2021-1-39.
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The pathophysiology of rosacea is a complex process in which the following factors are important: vascular disorders, changes in the connective tissue of the dermis, microorganisms, dysfunction of the gastrointestinal tract, immune disorders, changes in the sebaceous hair apparatus, oxidative stress, climatic factors, psycho-vegetative disorders, constitutional angiopathy, emotional stress, hormonal imbalance, exposure to chemical agents. Therapy for rosacea can be difficult for specialists and cause patient dissatisfaction due to a recurrent course. The treatment of severe forms of the disease is especially difficult. Traditional antibiotic therapy and correction of hormonal levels in women give a positive, but often temporary effect. Objective — to study the efficacy and tolerability of systemic isotretinoin in the treatment of papulopustular forms of rosacea. Materials and methods. The study involved 30 patients (21 women and 9 men) aged 39 to 56 years who had papulopustular rosacea. Evaluation of the effectiveness of therapy was carried out using the scale of diagnostic assessment of rosacea before and after 6 months from the start of treatment. All patients were prescribed systemic isotretinoin as monotherapy — the drug Roaccutane (F. Hoffmann-La Roche Ltd, Switzerland) in the following dose: during the 1st month — 0.3 mg/kg, during the 2th—6th months — 0.2 mg/kg once a day along with fatty foods. Results and dicsussion. Before treatment, the rosacea diagnostic scale score was (10.8 ± 0.9) points. After 6 months of therapy, it decreased 6 times and equaled to (1.8 ± 0.4) points. Conclusions. The analysis of the data obtained indicates a high efficiency of Roaccutane in the treatment of papulopustular forms of rosacea. Side effects in the form of dry skin and mucous membranes when taking Roaccutane were minor due to the low dose of the drug and were corrected with appropriate moisturizers.
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Smirnova, E. N., Evgeniya A. Loran, and S. G. Shulkina. "Vegetative regulation and endothelial dysfunction in patients with metabolic syndrome." Clinical Medicine (Russian Journal) 95, no. 6 (July 2, 2017): 549–52. http://dx.doi.org/10.18821/0023-2149-2017-95-6-549-552.
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Special attention is given to MS bearing in mind its high prevalence in the general population (up to 14-24 %) which is twice the prevalence of diabetes. The study included 50 patients with MS at the age of 25 to 61 years. The group of comparison contained 16 healthy individuals aged 45,3±2,3 years. To evaluate the response of microvascular tone, the wavelet analysis of fluctuations of skin temperature during limb cooling was used. Vascular endothelial growth factor (VEGF) served as a biochemical marker of endothelial dysfunction. Heart rate variability was evaluated in all patients. It was shown that patients with MS were significantly different in terms of all metabolic parameters; their VEGF levels were much higher than in the comparison group. Disturbances of vasodilation identified in the functional cold test in patients with MS confirm the relationship between abnormal vascular reactivity and endothelial dysfunction markers. The cardiointervalographic examination of MS patients revealed typical manifestations of autonomous cardiac neuropathy.
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Khrulev, A. E., N. A. Shiyanova, V. N. Grigorieva, G. N. Vlasov, L. S. Kоzulina, and A. T. Egorskaya. "Cerebral microangiopathy according to magnetic resonance imaging of the brain in patients undergoing longterm programmed hemodialysis." Russian neurological journal 27, no. 2 (May 14, 2022): 43–52. http://dx.doi.org/10.30629/2658-7947-2022-27-2-43-52.
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Introduction. Cerebral microangiopathy (CMA), being the leading cause of vascular cognitive impairment and strokes, has a number of causes, among which chronic kidney disease (CKD) and programmed hemodialysis (HD) are the least studied.Purpose of the study: to determine the frequency of CMA neuroimaging markers and risk factors for its development in patients receiving renal replacement therapy for a long time using the programmed HD.Material and methods: the study involved 70 patients who had been on programmed HD for 10 months or more. Clinical neurological examination, laboratory tests and brain MRI were performed. The analysis of CMA neuroimaging markers was carried out in accordance with the STRIVE recommendations. Cerebral Small Vessel Disease Score (CSVDS) was used to quantify the overall severity of MR imaging markers of CMA.Results. Among 70 examined (29 men and 41 women) aged 53.0 ± 14.2 years, average HD experience – 70.0 ± 39.5 months, the main clinical manifestations of CMA were cognitive impairment (82.9%, n = 58), emotional disorders (61.4%, n = 43), sleep disorders (38.6%, n = 27), pseudobulbar syndrome (17.1%, n = 12), walking disorders (8.6%, n = 6), acute lacunar syndromes (7.1%, n = 5) and pelvic dysfunction (4.3%, n = 3). CMA neuroimaging markers of varying severity were found in 100% of cases. Expansion of perivascular spaces (100%, n = 70) and white matter hyperintensities (81.4%, n = 57) prevailed in the structure of CMA imaging markers. Cortical atrophy (67%, n = 47), cerebral microbleeds (47%, n = 33), asymptomatic lacunae (35.7%, n = 25) and minor subcortical infarctions (2.9%, n = 3) were less common. Mild CMA (1–2 points on the CSVDS scale) was determined in 38 patients (54.3%), severe CMA (3–4 points on the CSVDS scale) – in 32 patients (45.7%). The presence of uncontrolled arterial hypertension (OR 1.85, p < 0.05), intradialysis hypertension (OR 2.8, p < 0.05), dialysis vegetative polyneuropathies (OR 2.75, p < 0.05), type 2 diabetes mellitus (OR 5.7, p < 0.05) and the experience of programmed HD (more than 50 months) (OR 3.1, p < 0.05) were prognostic signifi cance for the development of severe CMA in dialysis patients.Conclusion. All patients with end-stage CKD who have been on programmed HD for a long time are shown to undergo the brain MRI in order to timely diagnose CMA imaging markers and possible correction of therapy.
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Kashina-Yarmak, V. L., and Rak L. I. "Features of the physical development of girls with different course of puberty and level of adaptive capabilities." Ukrainian Journal of Pediatric Endocrinology, no. 4 (January 17, 2022): 34–39. http://dx.doi.org/10.30978/ujpe2021-4-34.
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The purpose of the study — to establish the features of the physical development of adolescent girls with the different course of puberty and to assess adaptive capabilities depending on the indicators of physical development and the course of puberty.Materials and methods: The examinations involved 57 girls aged 11 to 17 year who were divided into two groups depending on the presence of menstrual disorders. The first group included girls with physiological puberty. The second group consisted of girls with oligo or amenorrhea, and in isolated cases, with abnormal uterine bleeding, proio or polymenorrhea. The assessments included somatometric parameters, the results of the Ruffier test, the clinoortostatic test, cardiac morphometric indicators, and vascular reactivity according to Doppler ultrasound, the Kerdo index and Baevsky’s adaptive potential.Results and discussion. The significant frequency of tall and higher than average height was established as specific feature of girls regardless of the variant of puberty course (42.4 % with physiological and 42.8 % with pathological puberty). In general, the girls did not differ in height and body weight. In terms of Baevsky’s adaptive potential, 100 % of girls had a satisfactory adaptation level. The significant proportion of adolescent girls showed low exercise tolerance (63.7 % of girls with physiological and 50 % with pathological puberty). The high frequency of initial sympathy and the prevalence of normal vegetative support were recorded. Satisfactory and good results were more likely to be obtained by girls with puberty disorders. Girls with physiological puberty had a high incidence of hyperkinetic hemodynamic (37.5 % compared to 15.0 % in the second group, p < 0.05).The adaptive capabilities of girls with average height did not differ between groups with various puberty course. The tall girls of the first group had the higher frequency of the hyperkinetic type of hemodynamics, combined with best indices of vascular reactivity: two thirds of subjects demonstrated adequate increase in the diameter of the brachial artery in the sample with reactive hyperemia. In girls with menstrual dysfunction, the acceleration of growth was not accompanied by activation of the sympathoadrenal system, but they showed better results of exercise test. It could be assumed that presence of sexual hormones’ imbalance with testosterone prevalence, promotes these results and increases endurance of girls. However, the isolated Ruffier test does not fully reflect the satisfactory adaptation of an adolescent’s body. It is necessary to compare the results of the functional study of adolescent girls with the peculiarities of their hormonal status.Conclusions. A big proportion of girls with tall and higher than average height is the peculiarity of physical development of modern female adolescents. In the absence of pathology of puberty, the adaptive reactions of a body of an adolescent girl are characterized by increased exposure to the sympathoadrenal system. The use of Baevsky’s adaptive potential, calculated for adolescent patients, does not allow even screening to identify individuals at risk of stress or adaptation failure, which indicates the need to expand the scope of examination of adolescents using functional tests and calculation coefficients.
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Kurtieva, Sh. "24-HOUR BLOOD PRESSURE MONITORING IN ADOLESCENTS WITH VEGETATIVE DYSTONIA SYNDROME." American Journal of Medical Sciences and Pharmaceutical Research 04, no. 01 (January 1, 2022): 1–8. http://dx.doi.org/10.37547/tajmspr/volume04issue01-01.
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The aim of this study was to assess the results of 24-hour blood pressure monitoring (ABPM) in adolescents with autonomic dystonia syndrome. We examined 243 adolescents 12-18 years old with clinically and laboratory-instrumental confirmed dysfunction of the autonomic nervous system - autonomic dystonia syndrome. It was revealed that in adolescents with autonomic dystonia syndrome, as a result of ABPM, significant deviations from the standards recommended at the moment for assessing the results of ABPM in children were found. The identified deviations may indicate an increase in vascular tone in these children, as well as the presence of disorders associated with the development of cardiovascular complications in adulthood.
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Kolesnik, Olena. "Clinical and pathogenetic features and correction of hyperkinetic disorders in vegetative dysfunctions." Ukrains'kyi Visnyk Psykhonevrolohii, Volume 28, issue 1 (102) (March 25, 2020): 6–9. http://dx.doi.org/10.36927/20790325-v28-is1-2020-1.
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One of the early syndromes in vascular pathology is motor disorders in the form of tremor. We examined 101 patients with cerebral dystonia on the background of chronic cerebral ischemia with compensated and subcompensated stages (n = 55) and autonomic dystonia syndrome (n = 46). Pathological mechanisms of formation of trembling hyperkinesis in cerebral angiodystonia of different etiology have been studied. Participation in these processes of the autonomic nervous system (ANS) is established. It is proved that the severity of this type of motor disorders depends on the condition of the ANS at different levels of its organization, especially on the background of sympathicotonic effects, as well as the vegetative characteristics of the patient. At the same time, signifi cant changes in electrophysiological parameters, as well as data of vegetative, emotional, psychometric testing, were obtained. For an objective evaluation of the severity of the tremor, a tremograph with the calculation of an integrative tremographic index was used. Developed a complex of cerebral angiodystonia with hyperkinetic syndrome and the use of antioxidants, nootropic drugs, which allowed to reduce or eliminate subjective experiences, to increase the adaptation capacity of the organism with the normalization of sympatho-parasympathetic relationships, to the normalization of the organism. also inhibition of the implementation of trembling hyperkinesis in both research groups. The average values of the tremographic index decreased towards an adequate distribution with sympathicolytic influence on the indices of vegetative testing and caused skin sympathetic potentials. At the same time, a greater effect was achieved when using the proposed method of treatment, with the maximum — in the syndrome of autonomic dystonia, as well as in the compensated stage of chronic brain ischemia. Keywords: cerebral angioedema, cerebral ischemia, autonomic disorders, tremor, treatment
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Proshchenko, Olha, and Iryna Ventskivska. "Effect of hysterectomy with opportunistic salpingectomy for uterine fibroids on the development of genitourinary syndrome and ways of its reduction." Journal of Education, Health and Sport 12, no. 4 (April 20, 2022): 152–65. http://dx.doi.org/10.12775/jehs.2022.12.04.013.
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The article presents the assessment and analysis of the most important predictors and manifestations of genitourinary disorders in women of reproductive age after radical surgical treatment for uterine fibroids in the remote postoperative period. Ways of reducing the severity of symptoms are offered.
The aim of the study – to establish the influence of hysterectomy with opportunistic salpingectomy for uterine fibroids on manifestation and progression of genitourinary syndrome and ways of the reduction in its severity.
Materials and methods. Comprehensive clinical and laboratory assessment of the impact of hysterectomy with opportunistic salpingectomy for uterine fibroids on the development of metabolic syndrome was conducted at the gynecological department of the “Kyiv Perinatal Center”. The study included 160 women: 90 patients underwent vaginal classical and laporoscopic hysterectomy including fallopian tubes removal; and 70 patients underwent abdominal hysterectomy including fallopian tubes removal. Data on the assessment of pelvic floor condition and urogenital dysfunction were provided using a standardized POP-Q system, both at the stage of preoperative observation and for 1, 3 and 5 years after the surgery.
Research results and their discussion. The most important risk factors that allow forming groups of patients requiring individualized approach in the choice of surgical techniques and rehabilitation program were pointed out. The obtained results allowed to isolate UCDT markers in fractions above 20%. 19 women (11.86%) underwent ovarian surgeries and used gonadotropin-releasing hormone agonists. Genitourinary and sexual disorders were diagnosed in 27 cases (19.3%) 12 months after surgery. Vaginoscopy, performed 12 months after surgery, revealed atrophic vaginitis in 58 cases (36.25%) without significant difference in groups. Microscopy of urogenital smears was in norm only in 51 patients (31.86%). Complaints of dysuria were most common among patients (59 – 36.85%). The combination of sexual disorders and other manifestations (flatulence and intestinal discomfort, stool problems, vaginal microbiota disorders, pelvic floor descent, etc.) was revealed in a quarter of women (28 – 17.50%), and more often – after vaginal hysterectomy (17 – 18.89%). Clinical symptoms of urinary incontinence were observed against the background of a negative cough test in almost a third of patients (49 – 30.63%). They were combined with pollakiuria, nocturia, and imperative urgency, exacerbated by alcohol and accompanied by cystalgia and genital prolapse. The use of low doses of estradiol in the rehabilitation program improved the clinical and laboratory parameters of the urogenital tract, reducing the incidence of vulvovaginal atrophy by 13%, normalizing the biocenosis and vaginal pH, reducing clinical manifestations of urinary incontinence (pollakiuria and nocturnal pollakiuria) by 14%, feeling of incomplete bladder emptying – by 15%, stress urinary incontinence – by 16%, vaginal prolapse – by 11%, compared to the group with standard postoperative management, as well as reducing the severity of psycho-emotional and vegetative-vascular manifestations.
Conclusion. The expected effect of surgical recovery may be insufficient, and clinical symptoms of genitourinary syndrome may manifest in the postoperative period, which requires the development of clear algorithms for diagnosing urinary incontinence and pelvic floor failure in the preoperative stage and application of long-term preventive measures after hysterectomy in the remote postoperative period. There is no statistically significant difference in the development of genitourinary syndrome with different surgical approaches.
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Likhterman, Leonid B., Aleksandr D. Kravchuk, and Vladimir A. Okhlopkov. "Theory about traumatic brain injury effects. Part I. Definitions, classification, clinical signs and quantitative tomography." Clinical review for general practice 2, no. 5 (June 15, 2021): 25–29. http://dx.doi.org/10.47407/kr2021.2.5.00067.
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The paper presents the experience of assessment and treatment of 5000 cases of various traumatic brain injury (TBI) effects using brain imaging methods, minimally invasive and reconstructive neurosurgery. Definitions of TBI “effects” and “complications” have been proposed for the first time. Clinical and morphological classification of those has been developed, which identifies tissue effects, effects on cerebrospinal fluid system dynamics, and vascular effects of TBI. The major clinical symptoms of TBI effects have been described: neurologic deficit, mental dysfunctions, disturbances of vegetative function, epilepsy. Focal and diffuse alterations in brain tissue, intrathecal space and ventricular system resulting from TBI, identified by x-ray computed tomography, have been systematized. This has become the basis for investigation of pathogenesis and sanogenesis of brain disorders resulting from TBI, as well as for developing theory about the TBI effects.
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Sushko, V., O. Tatarenko, O. Kolosynska, and D. Hapieienko. "THE EXPERTISE OF THE CAUSAL RELATIONSHIP BETWEEN THE DEVELOPMENT OF ARTERIAL HYPERTENSION WITH PARTICIPATION IN WORKS FOR LIQUIDATION OF THE CONSEQUENCES OF CHORNOBYL NPP ACCIDENT IN REMOTE POSTACCIDENTAL PERIOD." Проблеми радіаційної медицини та радіобіології = Problems of Radiation Medicine and Radiobiology 25 (2020): 543–57. http://dx.doi.org/10.33145/2304-8336-2020-25-543-557.
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Loss of health and work ability, as well as deaths from diseases of the circulatory system (DCS), first of all arterial hypertension (AH), due to radiation exposure (RE) in the conditions of Chernobyl catastrophe (ChC) in the performance of professional, military or official duties and / or living on radiation-contaminated areas, additional exposure not through their own fault but due to a radiation accident, caused the development of a special form of medical expertise as part of the of medical social protection system for these suffered contingents. Objective: to optimize decision-making criteria for the expert estimation of the casual relationship between development and progression of AH under the influence of RE in clean-up workers of the Chornobyl NPP accident (CWs) in the remote postaccidental period based on the study of odds ratio (OR) of the course of the disease. Material and methods. A retrospective analysis of the structure of 16073 cases of victims of the Chornobyl NPP (ChNPP) accident, considered by the Central Interagency Expert Commission of Ministry of Health of Ukraine for diseases, reason of disability and death causal relationship to ChNPP accident (CIEC) during 2014–2016, allowed to form a group of 401 cases of CW with AH to determine the OR of the course of the disease. The main group consisted of 330 CWs for whom the development of AH has a causal relationship with the participation in the work for liquidation consequences of the Chornobyl NPP accident (WLAc), the comparison group – 71 CWs in respect of whom a negative expert decision was made. There were not significant differences between both groups of CWs in dose of external radiation exposure (DERE) in the main group – (0.155 ± 0.085) Sv, in CWs of the comparison group – (0.135 ± 0.086) Sv (р = 0.868). Results. In the remote postaccidental period, HSC take the second place (39.62 %) in the structure of medical expertise of the causal relationship of the diseases development and progression with RE for all categories of victims of the Chernobyl accident. The share of cases of AH was 28.4% of the total number of cases considered CWs. In the structure of cases of relationship of diseases of CWs that led to death, the share of AH was 17.8 %. In CWs the main group the AH developed in (9.4 ± 6.2) years after participation in WLAc, which is on average 6 years earlier than in the comparison group (р < 0.001). AH in the main group of CWs developed at the age of 5.8 years younger than in the comparison group (р = 0.0005). The need for inpatient treatment come 8.6 years earlier (14.6 ± 7.7 years) than in CWs comparison group (р < 0.001). At DERE 0,05 Sv and over, increases the probability of development and progression of AH that has causal relationship with participation in the WLAc. For medical expertise of the causal relationship of the AH development and progression with WLAc at DERE 0.20 Sv and over the significant evidence value have the next criteria: terms Somatoform Vegetative (autonomic) Dysfunction (SVD) development (within 3,5 years) and its transformation into AH (within 7 years), verification of the AH diagnosis (within 9,5 years), inpatient treatment for SVD or AH (within 15 years), vascular events (Acute Cerebrovascular Accident – Stroke (ACVA) – within 24 years after participation in the WLAc or 11 years after the AH diagnosed, myocardial infarction (MI) – within 22 years after participation in the WLAc or 10.5 years after the AH diagnosed), the establishment of permanent disability. Conclusion: Radiation factor has an evidence influence on the development and progression of AH in CWs. Criteria of the development and progression of AH in CWs can be used for evidence-based medical expertise for estimation of the causal relationship of the disease with the WLAc in the remote post accidental period at DERE more than 0.20 Sv. Key words: ionizing radiation, arterial hypertension, clean-up workers of Chornobyl NPP accident, medical expertise, Chornobyl catastrophe.
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Simonyan, Margarita A., Olga M. Posnenkova, and Anton R. Kiselev. "Capabilities of photoplethysmography as a method for screening of cardiovascular system pathology." Cardi-IT 7, no. 1 (September 30, 2020). http://dx.doi.org/10.15275/cardioit.2020.0102.
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Currently, vegetative dysfunction considered to be one of principal mechanisms in the pathogenesis of cardiovascular pathology, which causes a cascade of events leading to changes in the properties and a structure of vascular wall. This review article contains literature from various databases (Russian science citation index, PubMed, Google Shcolar, Scopus). It presents the methods for assessing vegetative imbalance. In particular, the method of photoplethysmography (PPGV) is considered for recording periodic fluctuations at various frequencies in the distal vascular bed which characterize physiological processes (cardiac activity, respiratory influences, neurogenic, myogenic and endothelial activity). In addition, other diagnostic capabilities of PPGV such as heart rate (HR) assessment, determining the properties of vascular wall and the level of blood saturation are elucidated. This paper demonstrates a wide range of PPGV applications. The simplicity of PPGV reproduction and its cost-effectiveness make it feasible both in routine clinical practice for the purposes of screening for cardiovascular pathology, and for individual health monitoring incorporated in smart devices.
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Paliienko, M. V., and Z. R. Kocherha. "COMPREHENSIVE ASSESSMENT OF RISK FACTORS FOR AUTONOMIC DYSFUNCTIONS IN SCHOOLCHILDREN AND THE POSSIBILITIES OF THEIR MANAGEMENT." Art of Medicine, July 3, 2021, 180–84. http://dx.doi.org/10.21802/artm.2021.2.18.180.
Full textAbstract:
The literature review is concerned with the analysis of current studies on the disorders of the autonomic nervous system in childhood. Autonomic dysfunction syndrome (ADS) occurs in the general child populaton in more than 20% of cases, and in some children may cause the development of many somatic diseases. Recently, there has been a tendency toward the increase in the number of children with manifestations of this pathology. This may be explained by the ambiguousness of the methodological approach, taking into account either all or markedly pronounced disorders only. The prevalence of vegetative dysfunction is obvious, even among people who consider themselves to be apparently healthy. Moreover, there are no such pathological conditions the development and course of which do not involve vegetative mechanisms.
Primary dysfunction of the autonomic nervous system initially causes functional disorders, particularly those of the cardiovascular system. In fact, arterial hypertension and hypotension are the basis for the development of such serious diseases of adults as coronary heart disease and hypertension leading to the development of serious complications.
The symptoms of vegetative-vascular dystonia are associated with the dysfunction and coordinated interaction of the two parts of the autonomic nervous system, rather than the pathology of any internal organ. It is important not to miss the patient’s subjective complaints related to the functioning of various organs which simulate the disease, but in fact no pathology is detected, as the clinical symptoms are associated with the imbalance of the nervous system. In case of any autonomic disturbance, the etiology and nature of the disorder should be clarified; the level of involvement of the autonomic nervous system, brain structures, parasympathetic and sympathetic autonomic formations must be determined.
As reported by the publications, psycho-emotional factors are among the main reasons that contribute to ADS development, especially in senior schoolchildren. In most of them, vegetative lability in puberty is unstable, but with additional exposure and a combination of other causes it stabilizes. That is why, special attention should be paid to the factors affecting children’s psycho-emotional state, the phenomenon of “bullying behavior” (bullying). Well-known bullying researchers have studied the reationships between young people at school and have concluded that bullying behavior involves some negative actions leading to resentment and chronic stress.
Some publications state that current stressful environment is a powerful trigger for nervous system dysfunction and can lead to negative consequences in adult life. The development of new approaches to the early diagnosis, treatment and prevention of this pathology in childhood is integral for reducing the incidence of the disease among adult population.
Nowadays, the management of autonomic vegetative nervous system dysfunction is significantly difficult. Vegetative stigmatization, which accompanies any pathological process, is routinely perceived as its obligatory component, inherent in both clinical symptoms of the disease and its pathogenesis.
Therefore, due attention is not always paid to the management of autonomic disorders in somatic pathology. Treatment of vegetative disturbances is based on conventional regimens, which are mostly ineffective; it is obvious that proper diagnosis and successful treatment requires individual approach to each patient.
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"The probable causes of the absence of pharyngeal tonsil involution in adolescents." Russian Otorhinolaryngology 18, no. 4 (2019): 39–43. http://dx.doi.org/10.18692/1810-4800-2019-4-39-4.
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Physiological shrinking (involution) of the pharyngeal tonsil occurs in adolescence due to the changes in the hormonal profile of the body. However, adenoids occur not only in adolescents but in adults as well. To clarify the etiology of the lymphoepithelial pharyngeal ring tonsils hypertrophy, the authors examined 46 children. Among them, there were 22 boys aged 13–18 years and 24 girls aged 12–18 years. According to the results obtained, the share of adolescents with concurrent endocrine diseases among all the adolescents operated on for adenoids was 40%, but only 10% subjected to regular check-up of an endocrinologist. 35% of children were obese, 25% had vegetative-vascular dysfunction manifestations. The tests for infections showed the persisting streptococcal infection in 25% of adolescents with high concentration of AS(L)O (300–800 units). 75% of patients had EBV and CMV. 25% of children had serological and molecular genetic markers, which indicate an active infectious process. It should be specifically noted that 1 child had HIV infection. The share of adolescents with allergic rhinitis and allergic diseases (atopic dermatitis, bronchial asthma) among all adolescents operated on for adenoids was 34%. Therefore, in 72.2% of cases, the adolescents had concurrent endocrine diseases or allergic rhinitis in combination with allergic diseases (atopic dermatitis, bronchial asthma), or persistent EBV, CMV or streptococcal infection, or a combination of these diseases (25%).
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Krychun, I. I., and N. V. Vasylieva. "POSSIBILITIES OF ARGININE-CONTAINING THERAPY IN THE TREATMENT OF NEUROLOGICAL MANIFESTATIONS OF OSTEOCHONDROSIS OF THE LUMBAR PART OF THE SPINE." Clinical & experimental pathology 20, no. 2 (August 15, 2021). http://dx.doi.org/10.24061/1727-4338.xx.2.76.2021.6.
Full textAbstract:
Purpose of the study – to estimate the pathogenetic expediency of L-arginine use inpatients with neurological manifestations of osteochondrosis of the spine lumbar parton the basis of estimation of the clinical picture, cerebral Doppler data and analysis ofthe blood plasma levels of some indices of endothelial dysfunction, such as fibronectin,soluble fms-similar tyrosine kinase 1 (sFlt - 1) and tumor necrotic factor (TNF-α),using Glutargine as an example. Material and methods. 104 male patients with neurological manifestations ofosteochondrosis of the lumbar spine at the age of 25-45 years (mean age 34.05 ± 5.7)without obesity, somatic and vascular pathology and 25 practically healthy persons,who did not differ in age from groups of the patients under study, have been examined.Among the examined patients, there were 50 patients with radiculopathies against abackground of herniated intervertebral discs, verified by means of neuroimaging, and54 patients with reflex manifestations of osteochondrosis of the lumbar part of the spine.The study of the clinical picture of osteochondrosis neurological manifestations of thelumbar spine was carried out by the method of standard neurological examinationusing a visual- analogue pain scale.The state of the autonomic nervous system was assessed using standard tests forautonomic reactivity and autonomic provision of activity, as well as using theQuestionnaire to identify signs of vegetative changes and the Study Scheme to identifysigns of autonomic disorders (O.M. Wein, 1993).The study of cerebral circulation was carried out by the method of extra-intracranialDoppler ultrasonography according to the standard techniques on the Sonomed-350apparatus using the Overshut test for cerebrovascular reactivity.Concentration of fibronectin in the blood plasma, tumor necrosis factor alpha andsoluble fms- similar tyrosine kinase was investigated by enzyme immunoassay accordingto the manufacturer's procedure under laboratory conditions.The paired Student's test and Fisher's angular Phi-transformation are used.Results. Statistically significant decrease of the pain syndrome has been revealedaccording to the VAS scale in the group of patients, who took Glutargin in the complextreatment. Significant changes in autonomic homeostasis have not been revealed whenusing Glutargin. The index of endothelium-dependent vasodilation in the group ofpatients, who took glutargin after treatment, approached the values of the control group(0.3 ± 0.06 at the values in the control group - 0.3 ± 0.096).Analysis of the data of fibronectin investigation, soluble fms-similar tyrosine kinase-1(sFlt - 1) and tumor necrotic factor (TNF-α) in the groups of patients with radicularmanifestations of osteochondrosis of the spine lumbar part before and after treatmenttestifies to that there were positive changes in the studied parameters in both groupsof patients, both with the use of standard treatment, and with the use of Glutargin,however, only in the group of patients, who took Glutargin in addition to the standardtreatment, a decrease in the content of fibronectin and tumor necrotic factor in bloodplasma acquired statistical significance. The increase in the indices of soluble fmslike tyrosine kinase-1 (sFlt - 1) in both groups of patients was insignificant and notstatistically veritable.Conclusions. Glutargin use in the complex treatment of patients with radicularneurological manifestations of lumbar osteochondrosis has a positive effect on theclinical course, reliably reducing the intensity of the pain syndrome and leads to animprovement in the endothelial functional state.