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Dissertations / Theses on the topic 'Vegfc'

Author: Grafiati

Published: 6 July 2024

Last updated: 31 July 2025

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1

Penco-Campillo, Manon. "Le VEGFC et les récepteurs CXCR1/2 : des cibles pertinentes pour le traitement des médulloblastomes pédiatriques." Electronic Thesis or Diss., Université Côte d'Azur, 2022. http://www.theses.fr/2022COAZ6025.

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Le médulloblastome (MB) est la tumeur pédiatrique cérébrale la plus fréquente et la plus agressive. Malgré un traitement multimodal agressif, entraînant des effets secondaires importants, 30% des patients développent une résistance et rechutent suite à l'apparition de métastases dans les 5 ans. Les récidives ne peuvent être contrôlées par des traitements conventionnels (radio et chimiothérapie) ou ciblés (anti-angiogénique, anti-inflammatoire, anti-point de contrôle immunitaire). L'objectif de ma thèse est donc de découvrir de nouvelles cibles et stratégies thérapeutiques pertinentes pour ces

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2

Decio, Alessandra Agnese. "The VEGFC/VEGFR3 pathway in the malignancy of ovarian carcinoma." Thesis, Open University, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606839.

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Vascular endothelial growth factor C (VEGFC) promotes tumor progression in several tumor types, mainly through the stimulation of lymphangiogenesis and lymphatic metastasis. The expression and biological significance of the VEGFCNEGFR3 pathway in ovarian cancer growth and dissemination has been investigated in this thesis using ovarian carcinoma cell lines and tumor animal models. In patient-derived ovarian carcinoma xenografts (HOC), high levels of soluble VEGFC in ascites and serum were detected, in association with disease progression and tumor burden. Peak VEGFC expression preceded para-ao

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3

Ferrão, Juliana Shimara Pires. "Tratamento com VEGFC para revascularização linfática em membros pélvicos de camundongos." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-08012014-112630/.

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A revascularização linfática é um desafio e o estabelecimento de novas estratégias terapêuticas podem melhorar a qualidade de vida de pessoas que sofrem de distúrbios linfáticos. O objetivo deste estudo foi verificar a capacidade de tratamento com VEGFC exógeno na melhoria da vascularização linfática de uma maneira dependente do tempo em membros pélvicos (MP) de camundongos após a remoção do linfonodo inguinal. O linfonodo inguinal esquerdo foi removido cirurgicamente para mimetizar patologias com diminuição da vascularização linfática. Densidade vascular linfática (Vv) e de comprimento (Lv) f

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4

Dellinger, Mike. "Contrasting Defects in Lymphangiogenic Remodeling and Lymphangiogenesis Revealed in Angiopoietin-2 Deficient and Vegfc Hemizygous Mice." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/195639.

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Despite recent advances in lymphology, the molecular mechanisms regulating the development of the lymphatic system have not been fully delineated. Here I show that the growth factors Angiopoietin-2 (Ang2) and Vascular endothelial growth factor-c (Vegfc) serve distinct roles in the development of the lymphatic system.Adult Ang2-/- mice exhibit dermal lymphatic hypoplasia, abnormal smooth muscle cell (SMC) coverage of initial lymphatic vessels, and a severe deficiency of collecting lymphatic vessels. To determine whether these abnormalities were due to defects in the remodeling of the lymphati

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5

Matsumura, Kazuyoshi. "Modulation of VEGFR-2-mediated endothelial-cell activity by VEGF-C/VEGFR-3." Kyoto University, 2003. http://hdl.handle.net/2433/148461.

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6

Silva, Luciana Oliveira da. "Expressão do fator de crescimento endotelial vascular (VEGF) e seus receptores VEGFR-1 e VEGFR-2 durante o início da gestação em camundongos." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-09092008-114452/.

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Em roedores, o aumento da permeabilidade vascular, a transformação decidual, e angiogênese são eventos cruciais para o sucesso da gestação. O fator endotelial vascular (VEGF) é um mitogênico para células endoteliais e um indutor de angiogênese. O VEGF age via dois receptores da família das tirosina quinases: VEGFR1 e VEGFR2. O objetivo deste estudo foi investigar usando o método imunohistoquímico, a expressão espacial e temporal do VEGF e os receptores VEGFR1 e VEGFR2 em células endometriais de camundongo entre o 4º e 8º dias de gestação. No 4º dia de gestação, VEGF, VEGFR1 e VEGFR2 foram expr

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7

Kranich, Sandra [Verfasser]. "Effekte der Wachstumsfaktoren VEGF-C und VEGF-D und Signaltransduktion des Rezeptors VEGFR-3 in Zellen des zentralen Nervensystems / Sandra Kranich." Kiel : Universitätsbibliothek Kiel, 2009. http://d-nb.info/1019868597/34.

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8

Reille-Seroussi, Marie. "Système VEGF/VEGFR : conception et évaluation de molécules ciblées et régulation potentielle par les métaux." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05P614/document.

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Dans les thérapies anticancéreuses, les traitements anti-angiogéniques agissant sur l’axe VEGF/VEGFR ont une place importante en clinique. Dans ce contexte, nous avons conçu et évalué l’activité de nouveaux inhibiteurs de l’interaction VEGF/VEGFR. Une première approche a été la conception de molécules antagonistes du VEGFR1. Différents analogues hétérocycliques dérivant d’un composé de type (3-carboxy-2-ureido) thiophène ont été synthétisés. Des réactivités chimiques intéressantes ont été mises en évidence, mais l’activité biochimique de ces molécules ne s’est pas révélée concluante. Une secon

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9

Olofsson, Birgitta. "Studies of the vascular endothelial growth factors, VEGFs, and their receptors, focusing on VEGF-B /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3633-1/.

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10

Homman, Ludiye Jihane. "Rôle et expression du facteur lymphangiogénique VEGF-C et de son récepteur VEGFR-3 au cours du développement du cerveau embryonnaire." Paris 6, 2008. http://www.theses.fr/2008PA066052.

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Le VEGF-C a été caractérisé pour son implication dans le développement des vaisseaux lymphatiques via l’activation de son récepteur à activité tyrosine kinase, VEGFR-3. Le VEGF-C liant également les récepteurs Neuropilines exprimés par les cellules neurales, nous avons examiné si les cellules neurales répondaient au VEGF-C et si elles exprimaient le VEGFR-3. J’ai d’abord montré, in vitro, que le VEGF-C stimule la prolifération des précurseurs neuraux exprimant le VEGFR-3 dans bulbe olfactif embryonnaire ainsi que la prolifération et la migration de précurseurs oligodendrocytaires du chiasma op

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11

Gonçalves, Silvana Beltrami. "Efeito do VEGF na angiogênese pulpar e na apoptose." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/25/25138/tde-22062007-094740/.

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O fator de crescimento vascular endotelial (VEGF) desempenha um papel importante na angiogênese, induzindo a proliferação da célula endotelial, migração e sobrevivência. Com o intuito de promover a formação de novos vasos, e obter uma melhora na circulação colateral, VEGF tem sido utilizado para o tratamento de áreas de isquemia cardíaca, na doença cardiovascular. A manutenção da vitalidade pulpar com VEGF pode melhorar o prognóstico dos dentes que sofreram avulsão, prevenindo a perda precoce do dente. O propósito deste estudo foi desenvolver um modelo para se estudar o processo de revasculari

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12

Sentilhes, Loïc. "Etudes in vivo de l'ontogénèse des systèmes VEGF/ VEGFR-2 et fibrinolytiques et applications à l'ischémie cérébrale périnatale." Rouen, 2010. http://www.theses.fr/2010ROUENR01.

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Les objectifs étaient d'étudier (i) la distribution temporo-spatiale du V EGF et VEGFR-2 par dans le cerveau et le cervelet humain normal ainsi que dans le cerveau humain ayant subi une hypoxie-ischémie, à différents âges gestationnels; (ii) le système fibrinol\Zique à la naissance en fonction de l'âge gestationnel de naissance des nouveaux-nés. Les résultats ont montré que (i) VEGF est impliqué dans plusieurs aspects du développement des cellules neurales (migration, différenciation, synaptogénèse, myélination), et que VEGFR-2 pourrait être un des principaux récepteurs médiant ces actions; (i

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13

Samikannu, Balaji [Verfasser]. "Dipeptidyl Peptidase IV inhibition activates CREB and improves islet vascularization through the VEGF-A/VEGFR-2 pathway / Balaji Samikannu." Gießen : Universitätsbibliothek, 2013. http://d-nb.info/1065065426/34.

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14

Veikkola, Tanja. "Dissecting VEGFR-2 and VEGFR-3 function : VEGFR-3 mediates lymphangiogenic signals." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/mat/bioti/vk/veikkola/.

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15

Mao, Kaili. "Rôle du Vascular Endothelial Growth Factor-A (VEGF-A) et de son récepteur VEGFR-1 dans le cancer prostatique localisé." Thesis, Paris Est, 2008. http://www.theses.fr/2008PEST0041/document.

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Ce travail a analysé l’expression du facteur de croissance angiogénique, le VEGF-A, et de son récepteur VEGFR-1, dans le cancer prostatique localisé. Dans la première partie, nous avons mesuré le taux plasmatique de VEGF-A chez 100 patients opérés d’un cancer prostatique localisé. Nous avons également mesuré l’expression tissulaire du VEGF-A sur les pièces opératoires. Il n’y avait pas d’association entre le VEGF-A plasmatique et les facteurs pronostiques du cancer prostatique. Cependant, l’expression du VEGF-A était corrélée au score de Gleason (p=0,01). Dans la deuxième partie, la même cohor

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16

Mao, Kaili Dinh-Xuan Anh-Tuan. "Rôle du Vascular Endothelial Growth Factor-A (VEGF-A) et de son récepteur VEGFR-1 dans le cancer prostatique localisé." S. l. : Paris Est, 2008. http://doxa.scd.univ-paris12.fr:80/theses/th0494618.pdf.

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17

Sjöström, Sara. "Risk and prognostic factors for malignant glioma." Doctoral thesis, Umeå universitet, Onkologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-61905.

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Background: Glioblastoma is the most common and aggressive type of glioma and associated with poor prognosis. Apart from ionizing radiation and some rare genetic disorders, few aetiological factors have been identified for primary brain tumours. Inverse associations to asthma and low IgG levels for varicella zoster virus have in previous studies indicated that the immune system may play a role in glioma development. Little is known about prognostic factors in glioma. Previous studies have shown an association between age, Karnofsky performance status, O6-methylguanine-DNA methyltransferase (MG

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18

Dias, Fernando José. "Influência de densidades do laser de baixa intensidade sobre o músculo masseter de ratos Wistar." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/58/58137/tde-12082010-150530/.

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A laserterapia tem sido muito utilizada como tratamento alternativo em pacientes com dores crônicas relacionadas às disfunções temporomandibulares. Isso se deve aos efeitos: analgésico, antiinflamatório, miorrelaxante, de redução da fadiga durante as contrações tetânicas, aumento da força de mordida e diminuição da dor orofacial. Embora sejam observados resultados clínicos, ainda não é bem compreendido o seu efeito em nível celular. Assim, este estudo tem como objetivo analisar os efeitos das diferentes densidades (doses) de irradiação do laser de baixa intensidade (LLLI), em nível celular, so

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19

Yin, Lu. "Rational Design and Development of Anti-Angiogenic Protein Agents." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/biology_diss/109.

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Inhibition of angiogenesis is an effective and low toxic therapeutic avenue for the treatment of cancer patients in addition to traditional interventions. Majority of current available angiogenesis inhibitors for cancer therapies are growth factor inhibitors and small molecule tyrosine kinase inhibitors. A number of endogenous proteins and/or proteolytic fragments of extracellular matrix proteins are shown to have the activity of inhibition of angiogenesis by directly targeting endothelial cells. Structural analyses have indicated that a common structure of anti-parallel β-sheet with a highly

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20

Soueid, Jihane. "Contribution des facteurs de croissance vasculaire et de leurs récepteurs au développement du SNC : rôle du VEGFR-3 et de son ligand VEGF-C." Paris 6, 2010. http://www.theses.fr/2010PA066667.

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J'ai étudié la contribution de la signalisation du facteur de croissance endothéliale vasculaire C (VEGF-C) et son récepteur VEGFR-3 à la neurogénèse postnatale. J'ai d'abord généré une lignée transgénique murine BAC Vegfr3::YFP. Au niveau de la zone subventriculaire adulte, Vegfc s'exprime dans les cellules épendymaires et astrogliales. Vegfr3 est exprimé par la majorité des astrocytes, incluant les cellules souches neurales (CSN) caractérisées par la possession d'un cil primaire, l'expression de GFAP et un cycle de division cellulaire lent. In vitro, ces cellules isolées par FACs à partir de

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21

Eubank, Tim. "M-CSF and GM-CSF induce human monocytes to express either pro- or anti-angiogenic factors." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1069772001.

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22

Colin, Maité [Verfasser], and Bernd [Akademischer Betreuer] Hohenstein. "Analyse von VEGF, VEGF-Aktivierung und VEGF-Rezeptorexpression bei humanen entzündlichen Nierenerkrankungen / Maité Colin. Betreuer: Bernd Hohenstein." Erlangen : Universitätsbibliothek der Universität Erlangen-Nürnberg, 2012. http://d-nb.info/1025963806/34.

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23

Nilsson, Ingrid. "Hypoxia, PDGF and VEGF in Vascular Development." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6894.

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24

Shi, Shuning. "VEGF-A, VEGF-B and PIGF in mouse oxygen induced retinopathy /." St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17390.pdf.

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25

Arantes, Ricardo Vinicius Nunes. "Estudo da angiogênese e da expressão temporal do VEGF e dos seus receptores VEGFR-1/Flt-1 e VEGFR-2/Flk-1 durante o reparo ósseo alveolar normal e com uso terapêutico de um antiinflamatório não esteroidal seletivo para COX-2 em ratos." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/25/25149/tde-12062012-151744/.

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Objetivo: Avaliar o efeito do Meloxicam sobre a expressão do VEGF e de seus receptores durante o reparo alveolar pós-exodontia em ratos. Material e Método: Foi realizada a exodontia do incisivo superior direito em 180 ratos Wistar, machos, com 60 dias de idade, subdivididos em dois grupos: 1) Grupo controle (n=90): os animais receberam injeção intraperitoneal de 0,1 ml de solução 0.9% NaCl diariamente, durante 7 dias; e 2) Grupo experimental (n=90): os animais receberam injeção diária de 3mg/kg de massa corporal de Meloxicam em solução 0.9%NaCl, durante 7 dias. Após 3, 7, 10, 14, 21 e 30 dias,

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Jeltsch, Michael. "VEGFR-3 ligands and lymphangiogenesis." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/mat/bioti/vk/jeltsch/.

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27

Sattler, Florentine [Verfasser], Sabine [Akademischer Betreuer] Mihm, Jochen [Akademischer Betreuer] Gaedcke, and Martin [Akademischer Betreuer] Oppermann. "Zytokinabhängige Expression von EGF und VEGF und ihrer Rezeptoren EGFR und VEGFR-1 im Tumormikromilieu des kolorektalen Karzinoms / Florentine Sattler. Gutachter: Jochen Gaedcke ; Martin Oppermann. Betreuer: Sabine Mihm." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2014. http://d-nb.info/1054191530/34.

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28

Capp, Clarissa. "Expressão do fator de crescimento endotelial vascular (VEGF) e de seus receptores (VEGFR 1 e 2) em amostras de tecido tireoidiano de pacientes com carcinoma medular de tireóide." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2009. http://hdl.handle.net/10183/17771.

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29

Scheidegger, Patrick. "Targeting of human endothelial cells by VEGF and VEGF-like peptide mimetics /." [S.l.] : [s.n.], 2000. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=13667.

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30

Agreste, Fernanda Rodrigues. "Expressão espaço-temporal do sistema VEGF e do EG-VEGF no timo de cães." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-08122010-154007/.

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O objetivo deste trabalho foi avaliar a expressão de fatores de crescimento responsáveis pelo processo vasculogênico durante o desenvolvimento e involução do timo em cães. Para este propósito, timos de fetos de cães (30, 40 50 e 60 dias de desenvolvimento), cães jovens (6 meses de idade) e cães adultos (1 ano de idade) foram coletados. Os tecidos foram analisados estereológicamente e submetidos à imunohistoquímica, PCR tempo real e western blot para os componentes do sistema VEGF (VEGF-A, VEGF-C, Flt-1, KDR e Flt-4) e endocrine gland-derived (EG)-VEGF. Pela estereologia, observamos um aumento

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31

Gomes, Luana Pimenta. "Avaliação dos fatores de crescimento endotelial vascular VEGF e de seus principais receptores VEGFR-1 e -2 no processo de cicatrização com influência da radioterapia em ratos da linhagem Wistar." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-05112013-125011/.

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Danos teciduais de qualquer natureza desencadeiam uma série de eventos que irão promover a regeneração ou a cicatrização do tecido lesado. Este reparo é um processo complexo que envolve a interação de diversos tipos celulares que são ativados por uma vasta gama de mediadores químicos, componentes da matriz extracelular, microorganismos e alterações físico químicas no microambiente da lesão e das áreas adjacentes. A participação do fator de crescimento endotelial vascular (VEGF) e de seus dois principais receptores (VEGFR-1 e -2) é de grande importância nos processos de cicatrização levando-se

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Onions, Karen. "The differential modification of glomerular endothelial cell glycocalyx by VEGF-A and VEGF-C." Thesis, University of Bristol, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.705456.

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33

Zanella, S. "SYNTHESIS OF PEPTIDOMIMETIC LIGANDS TARGETING CELL-SURFACE RECEPTORS INVOLVED IN TUMOR ANGIOGENESIS." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/473075.

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In the first part of the Thesis, the synthesis of different classes of peptidomimetics targeting integrin receptors is described. Both simple ligands and drug conjugates were synthesized and tested to assess their biological activity. In cancer therapy, peptides and peptidomimetics targeting integrins are employed as carriers to deliver cytotoxic drugs at the tumor site, taking advantage of integrin over-expression on the surface of tumor cells. Within this frame, synthetic efforts have been focused on the synthesis and on the conjugation to the cytotoxic agent paclitaxel of isoDGR-based integ

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Hedeen, Heather A. "A Kinetic Study of anti-VEGF-A Polyclonal Antibodies and anti-VEGF-A ssDNA Aptamers." DigitalCommons@CalPoly, 2012. https://digitalcommons.calpoly.edu/theses/754.

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A new detection reagent that could possibly augment or replace antibodies research and diagnosis methods are aptamers. Aptamers are ssDNA, RNA or polypeptide constructs that function like active antibodies. Antibodies and aptamers both specifically bind to selected target molecules, and as such they enable the detection or targeting of the presence or absence of a specific antigen. In order to ensure that ssDNA aptamers perform similarly to antibodies, anti-VEGF-A polyclonal antibody and anti-VEGF-A ssDNA aptamer were evaluated against vascular endothelial growth factor A (VEGF-A) using Surfa

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Cunningham, Crystal. "Expression of Chemokines and VEGFs in HNSCC." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1787.

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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. The 5-year survival rate when the cancer remains as a primary tumor is 81% but when it metastasizes to distant sites, defined as a metastatic cancer, it decreases dramatically to 26%. Approaches to prevent these cancers from undergoing these metastatic changes can greatly improve the survival and outcome of these cancer victims. This current study is examining the expression profiles of chemokines and VEGFs in HNSCC. By investigation the underlying pathways involved in the expressions of chemokines

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Spatola, Agata. "Studio della funzione del VEGF in modelli sperimentali di cellule." Thesis, Università degli Studi di Catania, 2011. http://hdl.handle.net/10761/234.

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Il danno epatico e' causato da diversi fattori che agiscono in vari modi. Il fegato ha pero' un'ottima capacita' rigenerativa dovuta a diverse molecole che agiscono sulla neovascolarizzazione e/o sulla proliferazione epatocitaria. Una di esse e' il VEGF per cui noi abbiamo voluto studiarne alcuni aspetti. Abbiamo allestito modelli sperimentali di HepG2 trattate con etanolo e VEGF. In un secondo esperimento le abbiam trattate con etanolo e con surnatante di cellule HUVEC( trattate con VEGF). Quindi abbiamo studiato in microarray l'espressione di diverse famiglie geniche nelle HUVEC e nel

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37

Klein, Johann [Verfasser]. "Kardiomyozytäre Effekte von VEGF / Johann Klein." Gießen : Universitätsbibliothek, 2012. http://d-nb.info/1064702996/34.

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Ourradi, Khadija. "Unravelling VEGF signalling in the lung." Thesis, University of Bristol, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683728.

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Vascular endothelial growth factor (VEGF) is a potent mitogenic, angiogenic and permeability factor that has been associated with the development of lung disease. The VEGF gene undergoes alternate splicing of exon 8 to produce two isoform families with differing functional effects. VEGF16sa is the most biologically active member of the VEGFxxxa family. One member of the VEGFxxxb family, VEGF16Sb, has "inhibitory" effects on VEGF16sa induced endothelial proliferation, migration and permeability. This study is based upon the hypothesis that these isoforms utilise differing signalling pathways, i

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Redondo, Alexandre Rodrigues. "Determinação do sítio de ligação de um peptídeo anti-angiogênico em seus receptores." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-11042017-084254/.

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A angiogênese é um processo fundamental e fisiológico de organismos vertebrados, sendo responsável pela formação de novos vasos sanguíneos a partir dos já existentes. Entretanto, a angiogênese pode ocorrer também em condições patológicas, como causa ou consequência de doenças. Um exemplo disso está nos tumores, que para crescer além de alguns milímetros cúbicos, necessitam de um suprimento adequado de oxigênio e nutrientes, e, portanto, dependem da angiogênese. Por isso, compostos que inibem a angiogênese já estão em uso na clínica, não só para o tratamento de tumores, mas também de outras doe

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40

Edholm, Dan. "VEGFR-2 in Endothelial Differentiation and Vascular Organization." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8579.

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41

Füger, Andrea Sylvia [Verfasser]. "Die Bedeutung der Angio-, Lymphangiogenesefaktoren VEGF, VEGF-C und VEGF-D für die Genese und Progression des Zervixkarzinoms und ihr Nutzen für die Diagnostik desselben / Andrea Sylvia Füger." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/1023582880/34.

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Almeida, Aroldo dos Santos. "Significado clínico da expressão de VEGF-C e de podoplanina em carcinomas espinocelulares de boca." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/25/25136/tde-02042009-103248/.

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A expressão do fator de crescimento endotelial vascular tipo C (VEGF-C) e de podoplanina pelas células malignas tem sido associada com a maior ocorrência de metástases regionais e/ou pior prognóstico para os pacientes com câncer de boca. O objetivo deste estudo foi avaliar o significado clinico da expressão de VEGF-C e podoplanina em 42 carcinomas espinocelulares (CEC) bem diferenciado de boca, com e sem comprometimento linfonodal, incluindo oito carcinomas verrucosos, tratados no Departamento de Cirurgia de Cabeça e Pescoço, do Hospital do Câncer A. C. Camargo, São Paulo, no período de 1980 a

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Mallory, Bradford Paul. "The Pulmonary Vasculature Mediates Differential Time-Sensitive Effects on Embryonic Lung Development." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1116510292.

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Treweeke, Andrew T. "Expression and function of VEGF and VEGF receptors in malignant B-cells from patients with chronic lymphocytic leukaemia." Thesis, University of Liverpool, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425473.

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Biedermann, Katrin. "Generation and Charakterization of VEGF-E-mutants." Zürich : ETH, Eidgenössische Technische Hochschule Zürich, Departement Chemie und Angewandte Biowissenschaften, 2005. http://e-collection.ethbib.ethz.ch/show?type=dipl&nr=173.

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Müller, Susanne. "VEGF als Surrogatmarker des Therapieverlaufes der pAVK /." Regensburg, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000254395.

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Sköld, Mattias. "On VEGF and related factors in neurotrauma /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-986-2/.

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Warren, Simon. "VEGF-hämmare vid behandling av våt makuladegeneration." Thesis, Umeå universitet, Kemiska institutionen, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-80892.

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Brash, James Thomas. "VEGF isoforms and NRP1 in vascular hyperpermeability." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10058912/.

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The cardiovascular system serves to deliver oxygen and nutrients to the tissues of the body whilst simultaneously removing waste products. Blood vessels display a degree of basal permeability to achieve this function, which is regulated at the level of the endothelial monolayer. In response to certain stimuli, the integrity of the endothelial barrier is reduced, rendering blood vessels hyperpermeable. Best known as a potent inducer of angiogenesis, the vascular endothelial growth factor (VEGF) was originally identified as a vascular permeability factor. In certain diseases, such as those chara

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Pawson, Elizabeth J. "VEGF gene therapy in experimental diabetic neuropathy." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.702481.

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