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Journal articles on the topic 'Vegfc'

Author: Grafiati

Published: 6 July 2024

Last updated: 31 July 2025

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1

Dormer, Anton, and Gregory Beck. "Evolutionary Analysis of Human Vascular Endothelial Growth Factor, Angiopoietin, and Tyrosine Endothelial Kinase Involved in Angiogenesis and Immunity." In Silico Biology: Journal of Biological Systems Modeling and Multi-Scale Simulation 5, no. 3 (2005): 323–39. https://doi.org/10.3233/isb-00190.

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Human vascular endothelial growth factor (VEGF), angiopoietin (ANG) and tyrosine kinase with immunoglobulin and epidermal growth factor homology domains (TIE)-2 consist of a grouping of proteins that are involved in vascular homeostasis, vascular integrity and angiogenesis. There are nine proteins in the immediate VEGF family: VEGFA, VEGFB, VEGFC, VEGFD, VEGF-3, placental growth factor (PGF), VEGF receptor (VEGFR)-1, VEGFR-2, and VEGFR-1-related. They can be stimulated by cytokines to become involved in immune responses. By using in silico tools, we were able to identify several possible analo

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Haiko, Paula, Taija Makinen, Salla Keskitalo, et al. "Deletion of Vascular Endothelial Growth Factor C (VEGF-C) and VEGF-D Is Not Equivalent to VEGF Receptor 3 Deletion in Mouse Embryos." Molecular and Cellular Biology 28, no. 15 (2008): 4843–50. http://dx.doi.org/10.1128/mcb.02214-07.

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ABSTRACT Lymphatic vessels play an important role in the regulation of tissue fluid balance, immune responses, and fat adsorption and are involved in diseases including lymphedema and tumor metastasis. Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR-3) is necessary for development of the blood vasculature during early embryogenesis, but later, VEGFR-3 expression becomes restricted to the lymphatic vasculature. We analyzed mice deficient in both of the known VEGFR-3 ligands, VEGF-C and VEGF-D. Unlike the Vegfr3 −/− embryos, the Vegfc −/−; Vegfd −/− embryos displayed normal blood vas

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Eldrid, Charles, Mire Zloh, Constantina Fotinou, et al. "VEGFA, B, C: Implications of the C-Terminal Sequence Variations for the Interaction with Neuropilins." Biomolecules 12, no. 3 (2022): 372. http://dx.doi.org/10.3390/biom12030372.

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Vascular endothelial growth factors (VEGFs) are the key regulators of blood and lymphatic vessels’ formation and function. Each of the proteins from the homologous family VEGFA, VEGFB, VEGFC and VEGFD employs a core cysteine-knot structural domain for the specific interaction with one or more of the cognate tyrosine kinase receptors. Additional diversity is exhibited by the involvement of neuropilins–transmembrane co-receptors, whose b1 domain contains the binding site for the C-terminal sequence of VEGFs. Although all relevant isoforms of VEGFs that interact with neuropilins contain the requi

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Fountzilas, G., N. Angouridakis, R. M. Wirtz, S. Claas, A. Nikolaou, and K. T. Kalogeras. "Prognostic value of VEGFC, HER2 and HER3 gene expression in recurrent squamous cell head and neck tumors." Journal of Clinical Oncology 24, no. 18_suppl (2006): 5538. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.5538.

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5538 Background: The main prognostic variables of head and neck squamous cell carcinoma (HNSCC) are the location and size of the tumor and the presence of cervical lymph node metastases. Differential gene expression of members of the HER and VEGF families is a common feature in HNSCC. To elucidate the prognostic value and the interrelation of these factors we performed a detailed gene expression analysis within HNSCC tissue samples Methods: We analyzed fresh frozen tissue from 48 recurrent HNSCC tumors stored at -80oC. RNA was isolated with the RNeasy kit (Qiagen, Inc.), followed by kinetic on

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Karimi, Hanieh, Sarah Lee, Wenqi Xu, et al. "Advances in Molecular Imaging of VEGFRs: Innovations in Imaging and Therapeutics." International Journal of Molecular Sciences 26, no. 11 (2025): 5373. https://doi.org/10.3390/ijms26115373.

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Vascular endothelial growth factor receptors (VEGFRs) are key regulators of angiogenesis, lymphangiogenesis, and vascular permeability, playing essential roles in both physiological and pathological processes. The VEGFR family, including VEGFR-1, VEGFR-2, and VEGFR-3, interacts with structurally related VEGF ligands (VEGFA, VEGFB, VEGFC, VEGFD, and placental growth factor [PlGF]), activating downstream signaling pathways that mediate critical cellular processes, including proliferation, migration, and survival. Dysregulation of VEGFR signaling has been implicated in numerous diseases, such as

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Secker, Genevieve A., and Natasha L. Harvey. "Regulation of VEGFR Signalling in Lymphatic Vascular Development and Disease: An Update." International Journal of Molecular Sciences 22, no. 14 (2021): 7760. http://dx.doi.org/10.3390/ijms22147760.

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The importance of lymphatic vessels in a myriad of human diseases is rapidly gaining recognition; lymphatic vessel dysfunction is a feature of disorders including congenital lymphatic anomalies, primary lymphoedema and obesity, while improved lymphatic vessel function increases the efficacy of immunotherapy for cancer and neurological disease and promotes cardiac repair following myocardial infarction. Understanding how the growth and function of lymphatic vessels is precisely regulated therefore stands to inform the development of novel therapeutics applicable to a wide range of human disease

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Sanmartin, Elena, Eloisa Jantus-Lewintre, Rafael Sirera, et al. "Prognostic value of “angiogenic” risk score in early-stage NSCLC." Journal of Clinical Oncology 30, no. 15_suppl (2012): 10594. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.10594.

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10594 Background: Angiogenesis is a key mechanism in tumor growth and dissemination mainly regulated by VEGF family members. We analyze the expression of 11 angiogenic genes in a cohort of resectable NSCLC patients and correlate them with clinico-pathological variables and prognosis. Methods: RNA was obtained from tumor and normal lung specimens from 175 NSCLC patients. RT-PCR was performed to assess the expression of HIF1-A, PIGF, VEGFA, VEGFB, VEGFC, VEGFD, VEGFR1, VEGFR2, VEGFR3, NRP1 and NRP2. Relative expression was normalized by an endogenous gene (GUS) using the Pfaffl formulae. Differe

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Jantus-Lewintre, Eloisa, Marta Usó, Elena Sanmartin, et al. "Ratios between VEGF ligands and receptors in tumor and stroma have impact on the outcome in resectable NSCLC." Journal of Clinical Oncology 31, no. 15_suppl (2013): e22147-e22147. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e22147.

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e22147 Background: In tumor angiogenesis there is a complex interplay between endothelial, stromal and tumor cells. Some key regulators of this process are the members of the vascular endothelial growth factor (VEGF) family of ligands and receptors and the neuropilins (NRP). This study analyzes the correlations between the expression of these angiogenic factors in tumor cells and tumor stroma, and their prognostic role in tissue samples from resected non-small cell lung cancer (NSCLC) patients. Methods: Representative tumor and stroma areas from FFPE tissue samples of 125 early-stage NSCLC pat

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Yang, Yi, Weiqiu Lan, Baihong Liu, and Yang Chen. "Abstract 3836: Discovery of a highly potent fully human VEGF nanobody from RenNano transgenic mice that exhibits a superior blocking activity on VEGF function." Cancer Research 85, no. 8_Supplement_1 (2025): 3836. https://doi.org/10.1158/1538-7445.am2025-3836.

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Abstract Background: VEGFA (or VEGF hereafter) is the prototypic member of a family that also includes placental growth factor (PLGF, also known as PGF),VEGFB,VEGFC,VEGFD . VEGFR2 is the major mediator of the physiological and pathological effects of VEGF. VEGFR2 mediates EC proliferation, migration and arterial fate specification [1]. VEGFA monoclonal antibodies have significant therapeutic effects in the treatment of tumors and macular degeneration [2]. In this study, we evaluated a fully human anti-VEGFA mAb generated from our fully human antibody RenNanoTM mice. Methods: Blocking activity

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Hunter, Stephanie, Braydon Nault, Kingsley Chukwunonso Ugwuagbo, Sujit Maiti, and Mousumi Majumder. "Mir526b and Mir655 Promote Tumour Associated Angiogenesis and Lymphangiogenesis in Breast Cancer." Cancers 11, no. 7 (2019): 938. http://dx.doi.org/10.3390/cancers11070938.

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MicroRNAs (miRNAs) are small endogenously produced RNAs, which regulate growth and development, and oncogenic miRNA regulate tumor growth and metastasis. Tumour-associated angiogenesis and lymphangiogenesis are processes involving the release of growth factors from tumour cells into the microenvioronemnt to communicate with endothelial cells to induce vascular propagation. Here, we examined the roles of cyclo-oxygenase (COX)-2 induced miR526b and miR655 in tumour-associated angiogenesis and lymphangiogenesis. Ectopic overexpression of miR526b and miR655 in poorly metastatic estrogen receptor (

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McCarter, Anna L., and Michael T. Dellinger. "Trametinib Inhibits Lymphatic Vessel Invasion of Bone in a Mouse Model of Gorham-Stout Disease." Journal of Vascular Anomalies 4, no. 4 (2023): e070. http://dx.doi.org/10.1097/jova.0000000000000070.

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Objective: Gorham-Stout disease (GSD) is a rare lymphatic anomaly that can be caused by somatic activating mutations in KRAS. This discovery has led investigators to suggest that MEK inhibitors could be a novel treatment for GSD. However, the effect of MEK inhibitors on bone disease in animal models of GSD has not been investigated. We recently reported that Osx-tTA;TetO-Vegfc mice exhibit a phenotype that resembles GSD. Osx-tTA;TetO-Vegfc mice overexpress vascular endothelial growth factor-C (VEGF-C) in bone, which stimulates the development of lymphatic vessels in bone and the gradual loss o

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Lim, Lillian, Hung Bui, Olivia Farrelly, et al. "Hemostasis stimulates lymphangiogenesis through release and activation of VEGFC." Blood 134, no. 20 (2019): 1764–75. http://dx.doi.org/10.1182/blood.2019001736.

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Key Points Platelet activation supports lymphatic vessel growth during wound healing through release of the lymphangiogenic factor VEGFC. Thrombin and plasmin support lymphatic vessel growth through proteolytic activation of the lymphangiogenic factors VEGFC and VEGFD.

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Chen, Yan, and Ying Chang. "Submucosal Dissection in Treating Rectal Neuroendocrine Tumors and Prognostic Analysis." Journal of Clinical and Nursing Research 9, no. 4 (2025): 91–96. https://doi.org/10.26689/jcnr.v9i4.10357.

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Objective: To analyze the application value of modified endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) in rectal neuroendocrine tumors, with a view to providing new clinical options for the early diagnosis and treatment of patients with such tumors, and thus improving their prognosis. Methods: Seventy-two patients with rectal neuroendocrine tumors who underwent surgical treatment in a hospital between October 2023 and September 2024 were selected and divided into a control group and an observation group using the mean score method, each with 36 cases. In the cont

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Dumond, Aurore, Christopher Montemagno, Valérie Vial, Renaud Grépin, and Gilles Pagès. "Anti-Vascular Endothelial Growth Factor C Antibodies Efficiently Inhibit the Growth of Experimental Clear Cell Renal Cell Carcinomas." Cells 10, no. 5 (2021): 1222. http://dx.doi.org/10.3390/cells10051222.

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Despite improvement during the last ten years in the longevity of patients with metastatic clear cell renal cell carcinoma (mccRCC) the disease remains incurable. Hence, new therapeutic strategies are urgently needed. Relapse following anti-angiogenic treatment depends on the over-expression of vascular endothelial growth factor C (VEGFC), one of the main drivers of lymphangiogenesis. Therefore, we developed specific mouse monoclonal antibodies and evaluated their therapeutic efficacy in vitro and in vivo. Immunization of mice with the domain of VEGFC that stimulates the VEGF receptor 3 (VEGFR

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Foley, Colleen, Lambert Potin, and Melody Swartz. "Increased DC trafficking and T cell memory in lymphangiogenic melanoma model during immunotherapy response." Journal of Immunology 212, no. 1_Supplement (2024): 1387_5116. http://dx.doi.org/10.4049/jimmunol.212.supp.1387.5116.

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Abstract High vascular endothelial growth factor-C (VEGFC) and lymphatic vessel density in the tumor microenvironment (TME) are associated with lymph node (LN) metastasis, immunosuppression, and poor prognosis in melanoma and other solid tumors. Paradoxically, high VEGF-C also renders immunotherapy more effective in mouse models and correlates with survival after immune checkpoint therapy in patients. Here, we asked how VEGF-C may alter the systemic anti-tumor immune response in melanoma to drive response to immunotherapy, focusing on immune cell trafficking and memory T cell development durin

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Shi, Xinwei, Guoqiang Zheng, Hao Liu, et al. "Vascular endothelial growth factor C participates in regulation of maspin in extravillous trophoblast cell migration and invasion." Reproduction, Fertility and Development 31, no. 8 (2019): 1410. http://dx.doi.org/10.1071/rd18438.

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Mammary serine protease inhibitor (maspin; also known as serpin family B member 5 (SERPINB5)) plays a vital role in regulating the biological functions of extravillous trophoblast (EVT) cells, but the mechanism remains unclear. Vascular endothelial growth factor (VEGF) C is a signature angiogenic molecule expressed and secreted by first-trimester trophoblasts, and bioinformatics analyses has revealed upregulation of VEGFC in pre-eclampsia. The aim of this study was to explore whether maspin regulates EVT cells by regulating the expression of VEGFC. Reverse transcription–polymerase chain reacti

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Kim, Hyeong Su, Dae Young Zang, Sung-Hwa Sohn, Bohyun Kim, and Hee Jung Sul. "Effect of tivantinib on VEGF signaling pathways and apoptosis of gastric cancer cells with c-MET or VEGFA amplification." Journal of Clinical Oncology 37, no. 15_suppl (2019): e14719-e14719. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e14719.

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e14719 Background: VEGFA is the key mediator of angiogenesis in cancer and previous studies reported that VEGFA expression was significantly up-regulated in gastric cancer tissues compared with matched normal tissues. We showed that increased levels of VEGFA are significantly associated with expression of hepatocyte growth factor receptor (MET) (r = 0.6255, P < 0.0001). In addition, it is well known that c-MET is potentially a highly plausible target for cancer therapy in gastric cancer. In this study, cytotoxic activity of tivantinib were evaluated in gastric cancer cells with high c-MET e

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Xu, Kai, Chuan-ling Wu, Zhi-xin Wang, et al. "VEGF Family Gene Expression as Prognostic Biomarkers for Alzheimer’s Disease and Primary Liver Cancer." Computational and Mathematical Methods in Medicine 2021 (November 20, 2021): 1–15. http://dx.doi.org/10.1155/2021/3422393.

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Background. To analyze the expression of vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC) and cognitive impairment, explore the relationship between the expression of VEGF family genes and prognosis of patients with HCC, and evaluate the predictive ability of VEGF in cognitive impairment using computerized methods. Methods. VEGF expression in liver cancer tissues and normal tissues was analyzed using bioinformatics methods. The Kaplan-Meier survival analysis method was also used to analyze the relationship between VEGF expression and the prognosis of patients with HC

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de Jonge, Hendrik JM, Peter Valk, Kim R. Kampen, et al. "VEGFC Predicts Poor Outcome in Pediatric as Well as Adult Acute Myeloid Leukemia: Insights in Associated Gene Expression Profiles." Blood 114, no. 22 (2009): 997. http://dx.doi.org/10.1182/blood.v114.22.997.997.

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Abstract Abstract 997 Poster Board I-19 A high vascular endothelial growth factor-C (VEGFC) mRNA level of primary blasts of pediatric Acute Myeloid Leukemia (AML) patients correlates with increased in vitro drug resistance and slow AML blast disappearance during induction therapy in vivo; measured by higher blast counts on day 15 in the bone marrow and a prolonged interval towards complete remission (HJM de Jonge et al. Clinical Cancer Research 2008). We set out to study both the effect of VEGFC on long term survival in AML and elucidate gene expression profiles associated with VEGFC expressio

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Girling, Jane E., and Peter A. W. Rogers. "Regulation of endometrial vascular remodelling: role of the vascular endothelial growth factor family and the angiopoietin–TIE signalling system." REPRODUCTION 138, no. 6 (2009): 883–93. http://dx.doi.org/10.1530/rep-09-0147.

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Angiogenesis, lymphangiogenesis and vascular maturation occur on a regular, physiological basis in human endometrium. These processes form part of a continuum of vascular remodelling involving numerous regulatory factors. Key factors include vascular endothelial growth factor (VEGF)A, VEGFC and VEGFD, and their associated receptors VEGFR1, VEGFR2 and VEGFR3. A second group of vascular regulatory proteins belongs to the angiopoietin (ANG)–TIE system. Although members of the VEGF family and the ANG–TIE system are represented in the endometrium, our understanding of how these different molecules

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Zhang, Xufan, Qian Chen, Yuchen Li, Hongqing Chen, Qin Jiang, and Qiongying Hu. "N-myc Downstream-Regulated Gene 1 (NDRG1) Regulates Vascular Endothelial Growth Factor A (VEGFA) and Malignancies in Glioblastoma Multiforme (GBM)." BioMed Research International 2022 (June 30, 2022): 1–9. http://dx.doi.org/10.1155/2022/3233004.

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Background. NDRG1 has been reported to exhibit relatively low expression levels in glioma tissues compared with adjacent brain tissues. Additionally, NDRG1 is reported to be a tumor suppressor with the potential to suppress the proliferation, invasion, and migration of cancer cells. However, its exact roles in GBM are still unknown. Methods. Gene Expression Profiling Interactive Analysis (GEPIA) was employed to evaluate the expression level of NDRG1 in GBM. After the introduction of NDRG1, proliferation, analyses of colony formation, migration, and invasion capacities were performed. A lucifer

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Foley, Colleen, Lambert Potin, Casey Propst, and Melody A. Swartz. "Abstract LB075: VEGF-C remodels the tumor microenvironment during immunotherapy response in melanoma and promotes T cell memory." Cancer Research 85, no. 8_Supplement_2 (2025): LB075. https://doi.org/10.1158/1538-7445.am2025-lb075.

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Abstract Tumor-associated lymphatic vessels are clinically linked to aggressive tumor progression and metastasis. Their expansion is driven by vascular endothelial growth factor-C (VEGF-C), which is highly expressed in the tumor microenvironment (TME) in melanoma and other solid tumors. Although elevated VEGF-C promotes an immunosuppressive TME, it paradoxically also enhances the response to immunotherapy in mouse models and correlates with improved survival after checkpoint blockade in patients. This enhanced response was associated with VEGF-C-induced alterations in the tumor microenvironmen

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CHIPUC, STEFANIA, HAINEALA BOGDAN, DRAGOS SERBAN, DUMITRU CRISTINEL BADIU4\, ANCA ZGURA, and RODICA ANGHEL. "Immunotherapeutic Innovations in Clear Cell Renal Cell Carcinoma: Current Strategies and Future Directions." Cancer Diagnosis & Prognosis 4, no. 5 (2024): 558–62. http://dx.doi.org/10.21873/cdp.10363.

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Approximatively 80% of kidney cancers globally are clear cell kidney cancers (ccRCCs), with 80% of these malignancies featuring an inactivating mutation of the Von Hippel-Lindau gene. This genetic alteration leads to the stabilization of hypoxia inducible factors 1 and 2 alpha (HIF 1 and 2α), resulting in the over-expression of target genes such as vascular endothelial growth factor (VEGF), which is crucial for angiogenesis. As a result, ccRCCs are highly vascularized and serve as models for anti-angiogenic treatments (AAT). Current AAT therapies comprise antibodies targeting VEGFs, tyrosine k

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Nadarajah, Noeline, Dörte Schulte, Vivienne McConnell, et al. "A Novel Splice-Site Mutation in VEGFC Is Associated with Congenital Primary Lymphoedema of Gordon." International Journal of Molecular Sciences 19, no. 8 (2018): 2259. http://dx.doi.org/10.3390/ijms19082259.

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Lymphedema is characterized by chronic swelling of any body part caused by malfunctioning or obstruction in the lymphatic system. Primary lymphedema is often considered genetic in origin. VEGFC, which is a gene encoding the ligand for the vascular endothelial growth factor receptor 3 (VEGFR3/FLT4) and important for lymph vessel development during lymphangiogenesis, has been associated with a specific subtype of primary lymphedema. Through Sanger sequencing of a proband with bilateral congenital pedal edema resembling Milroy disease, we identified a novel mutation (NM_005429.2; c.361+5G>A) i

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Marcozzi, Cristiana, Annalisa Frattini, Marina Borgese, et al. "Paracrine effect of human adipose-derived stem cells on lymphatic endothelial cells." Regenerative Medicine 15, no. 9 (2020): 2085–98. http://dx.doi.org/10.2217/rme-2020-0071.

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Aim: The proposal of this study was to evaluate, in vitro, the potential paracrine effect of human adipose-derived stem cells (hASCs) to promote lymphangiogenesis in lymphatic endothelial cells isolated from rat diaphragmatic lymphatic vessels. Materials & methods: ELISA on VEGFA, VEGFC and IL6 in hASC-conditioned medium; LYVE1 immunostaining; and gene expression of PROX1, VEGFR3, VEGFC, VEGFA and IL6 were the methods used. Results: In 2D culture, hASC-conditioned medium was able to promote lymphatic endothelial cell survival, maintenance of endothelial cobblestone morphology and induction

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Hong, Kwang Dae, Youngseok Lee, Baek-Hui Kim, Sun Il Lee, and Hong Young Moon. "Expression of GLI1 Correlates with Expression of Lymphangiogenesis Proteins, Vascular Endothelial Growth Factor C and Vascular Endothelial Growth Factor Receptor 3, in Colorectal Cancer." American Surgeon 79, no. 2 (2013): 198–204. http://dx.doi.org/10.1177/000313481307900232.

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Aberrant activation of the hedgehog (Hh) signaling pathway is associated with tumorigenesis in various tissues. In colorectal cancer (CRC), evidence for Hh activation is inconsistent, and the relationship between the Hh signaling pathway and lymphangiogenesis has not been studied. The aim of this study was to determine the relationship between Hh signaling and lymphangio-genesis and the association of this relationship with lymph node metastasis in CRC. We investigated 189 patients who underwent curative surgical resection for CRC between 2002 and 2004 at Korea University Guro Hospital. Paraff

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de Jonge, Hendrik J. M., Peter J. M. Valk, Nic J. G. M. Veeger, et al. "High VEGFC expression is associated with unique gene expression profiles and predicts adverse prognosis in pediatric and adult acute myeloid leukemia." Blood 116, no. 10 (2010): 1747–54. http://dx.doi.org/10.1182/blood-2010-03-270991.

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Abstract High VEGFC mRNA expression of acute myeloid leukemia (AML) blasts is related to increased in vitro and in vivo drug resistance. Prognostic significance of VEGFC on long-term outcome and its associated gene expression profiles remain to be defined. We studied effect of VEGFC on treatment outcome and investigated gene expression profiles associated with VEGFC using microarray data of 525 adult and 100 pediatric patients with AML. High VEGFC expression appeared strongly associated with reduced complete remission rate (P = .004), reduced overall and event-free survival (OS and EFS) in adu

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Gula, Grzegorz, Sławomir Rumiński, Justyna Niderla-Bielińska, et al. "Potential functions of embryonic cardiac macrophages in angiogenesis, lymphangiogenesis and extracellular matrix remodeling." Histochemistry and Cell Biology 155, no. 1 (2020): 117–32. http://dx.doi.org/10.1007/s00418-020-01934-1.

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AbstractThe role of cardiac tissue macrophages (cTMs) during pre- and postnatal developmental stages remains in many aspects unknown. We aimed to characterize cTM populations and their potential functions based on surface markers. Our in situ studies of immunostained cardiac tissue specimens of murine fetuses (from E11to E17) revealed that a significant number of embryonic cTMs (phenotyped by CD45, CD68, CD64, F4/80, CD11b, CD206, Lyve-1) resided mostly in the subepicardial space, not in the entire myocardial wall, as observed in adult individuals. cTMs accompanied newly developed blood and ly

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De Alarcon, Pedro, Manu Gnanamony, and Jessica Garcia. "An in Vitro Study on the Role of Angiogenesis in Iron Deficiency Induced Reactive Thrombocytosis." Blood 132, Supplement 1 (2018): 2450. http://dx.doi.org/10.1182/blood-2018-99-115378.

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Abstract Introduction: Iron deficiency (ID) is one of the recognized causes of reactive thrombocytosis in children. Factors that are commonly associated with megakaryopoiesis such as thrombopoietin (TPO), interleukin 6 (IL-6) and IL-11 are not altered in patients with iron deficiency and thrombocytosis suggesting the role of alternate mechanisms in controlling this process. We have previously shown using an ID rat model that ID increased the number of megakaryocytes in the bone marrow. We have also shown an increase in VEGFR (FLT1) and CXCR4 staining in bone marrow slides of ID rats. This data

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Zhao, Liangyu, Chencheng Yao, Zijue Zhu, et al. "Intra-Seminiferous Tubular Injection of Vascular Endothelial Growth Factor C Sustained-Release Ultrafine Particles: A Novel Method for Improving the Regeneration of Spermatogenesis After Chemotherapy." Journal of Biomedical Nanotechnology 15, no. 12 (2019): 2376–92. http://dx.doi.org/10.1166/jbn.2019.2857.

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Busulfan and other chemotherapeutic drugs used in the treatment of cancer may result in temporary or even permanent damage to spermatogenesis. During spermatogenesis, the rapidly dividing spermatogonia are highly susceptible to chemotherapy. Consequently, there is significant interest in developing an approach that could provide stimulation and regenerate spermatogenesis after chemotherapy. In a previous study, we suggested the potential application for vascular endothelial growth factor C (VEGFC) because of its key role in stimulating the proliferation of spermatogonia. However, methods to fa

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Bui, Hung M., David Enis, Marius R. Robciuc, et al. "Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD." Journal of Clinical Investigation 126, no. 6 (2016): 2167–80. http://dx.doi.org/10.1172/jci83967.

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Morfoisse, Florent, Fabienne De Toni, Jeremy Nigri, et al. "Coordinating Effect of VEGFC and Oleic Acid Participates to Tumor Lymphangiogenesis." Cancers 13, no. 12 (2021): 2851. http://dx.doi.org/10.3390/cancers13122851.

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In cancer, the lymphatic system is hijacked by tumor cells that escape from primary tumor and metastasize to the sentinel lymph nodes. Tumor lymphangiogenesis is stimulated by the vascular endothelial growth factors-C (VEGFC) after binding to its receptor VEGFR-3. However, how VEGFC cooperates with other molecules to promote lymphatics growth has not been fully determined. We showed that lymphangiogenesis developed in tumoral lesions and in surrounding adipose tissue (AT). Interestingly, lymphatic vessel density correlated with an increase in circulating free fatty acids (FFA) in the lymph fro

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Wu, Lichuang, Chenxian Su, Chuanhua Yang, Jinxing Liu, and Yiheng Ye. "TBX3 regulates the transcription of VEGFA to promote osteoblasts proliferation and microvascular regeneration." PeerJ 10 (July 11, 2022): e13722. http://dx.doi.org/10.7717/peerj.13722.

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Objective Osteochondral decellularization can promote local vascular regeneration, but the exact mechanism is unknown. The aim of this study is to study osteogenic microvascular regeneration in single cells. Methods The scRNA-seq dataset of human periosteal-derived cells (hPDCs) were analyzed by pySCENIC. To examine the role of TBX3 in osteogenesis and vascularization, cell transfection, qRT-PCR, western blot, and CCK-8 cell proliferation assays were performed. Results TCF7L2, TBX3, FLI1, NFKB2, and EZH2 were found to be transcription factors (TFs) most closely associated with corresponding ce

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Çoban, Zehra Dilşad, Mustafa Yener, Ahmet Samed Benli, et al. "KANTARON YAĞI VEGFA, VEGFB, VEGFC ve FGF2 GENLERİ ÜZERİNDEN ERKEN DÖNEM KULLANILDIĞINDA YARA İYİLEŞMESİNDE OLUMLU ETKİ GÖSTERMEKTEDİR." Cumhuriyet Medical Journal 38, no. 4 (2016): 231. http://dx.doi.org/10.7197/cmj.v38i4.5000101540.

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Cohen, Batya, Hanoch Tempelhof, Tal Raz, et al. "BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expression." Life Science Alliance 3, no. 4 (2020): e202000666. http://dx.doi.org/10.26508/lsa.202000666.

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Angiogenesis and lymphangiogenesis are key processes during embryogenesis as well as under physiological and pathological conditions. Vascular endothelial growth factor C (VEGFC), the ligand for both VEGFR2 and VEGFR3, is a central lymphangiogenic regulator that also drives angiogenesis. Here, we report that members of the highly conserved BACH (BTB and CNC homology) family of transcription factors regulate VEGFC expression, through direct binding to its promoter. Accordingly, down-regulation of bach2a hinders blood vessel formation and impairs lymphatic sprouting in a Vegfc-dependent manner d

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Fang, Shentong, Shuo Chen, Harri Nurmi, et al. "VEGF-C protects the integrity of the bone marrow perivascular niche in mice." Blood 136, no. 16 (2020): 1871–83. http://dx.doi.org/10.1182/blood.2020005699.

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Abstract Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) stem cell niche, which provides a vital source of HSC regulatory signals. Radiation and chemotherapy disrupt the HSC niche, including its sinusoidal vessels and perivascular cells, contributing to delayed hematopoietic recovery. Thus, identification of factors that can protect the HSC niche during an injury could offer a significant therapeutic opportunity to improve hematopoietic regeneration. In this study, we identified a critical function for vascular endothelial growth factor-C (VEGF-C), that of maintaining the integr

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Kampen, Kim R., Arja ter Elst, André B. Mulder, Megan E. Baldwin, Klupacs Robert, and Evelina S. J. M. de Bont. "Anti-VEGFC Treatment Reduces the Leukemic Outgrowth of Primary CD34+ Pediatric Acute Myeloid Leukemia Cells." Blood 118, no. 21 (2011): 1425. http://dx.doi.org/10.1182/blood.v118.21.1425.1425.

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Abstract Abstract 1425 Previously, it was demonstrated that exogenous addition of vascular endothelial growth factor C (VEGFC) increased the leukemic cell viability, reduced apoptosis via activation of Bcl-2, and decreased chemotherapy induced apoptosis via its receptor FLT-4 (Further revert to as VEGFR3) (Dias et al. Blood 2002). Furthermore, it was shown that VEGFC promotes angiogenesis by induction of COX-2 through VEGFR3 activation in THP-1 cells (Chien et al. Carcinogenesis 2005). We have previously found that endogenous VEGFC expression is associated with decreased drug responsiveness in

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Fang, Shentong, Harri Nurmi, Krista Heinolainen, et al. "Critical requirement of VEGF-C in transition to fetal erythropoiesis." Blood 128, no. 5 (2016): 710–20. http://dx.doi.org/10.1182/blood-2015-12-687970.

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Key Points Vegfc is essential for mobilization, maturation, and enucleation of primitive erythroblasts. Vegfc deletion compromises liver colonization by erythro-myeloid progenitors and subsequent macrophage/erythroid expansion.

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García-Pérez, Omar, Leticia Melgar-Vilaplana, Inés Sifaoui, Aleksandra Śmietańska, Elizabeth Córdoba-Lanús, and Ricardo Fernández-de-Misa. "VEGFC Gene Expression Is Associated with Tumor Progression and Disease-Free Survival in Cutaneous Squamous Cell Carcinoma." International Journal of Molecular Sciences 25, no. 1 (2023): 379. http://dx.doi.org/10.3390/ijms25010379.

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Cutaneous squamous cell carcinoma (CSCC) is one of the most common cancers in the skin. CSCC belongs to the non-melanoma skin cancers, and its incidence is increasing every year around the world. The principal routes of tumor progression are related to angiogenesis and lymphangiogenesis. In this study, we assess the gene expression of the relevant biomarkers of both routes in 49 formalin-fixed paraffin-embedded (FFPE) CSCC samples in an attempt to determine a molecular profile that correlates with the tumor progression and disease-free survival (DFS). The results were enhanced by a posttranscr

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Shibuya, Masabumi. "Unique signal transduction of the VEGF family members VEGF-A and VEGF-E." Biochemical Society Transactions 37, no. 6 (2009): 1161–66. http://dx.doi.org/10.1042/bst0371161.

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Both VEGF (vascular endothelial growth factor)-A and Orf-virus-encoded VEGF-E bind and activate VEGFR (VEGF receptor)-2; however, only VEGF-A binds VEGFR-1. To understand the biological differences between VEGF-A and VEGF-E in vivo, we established transgenic mouse models. K14 (keratin-14)-promoter-driven VEGF-E transgenic mice showed a significant increase in mature blood vessels. However, K14–VEGF-A transgenic mice exhibited severe inflammation and oedema with increased angiogenesis, as well as lymphangiogenesis and lymph vessel dilatation. K14–VEGF-A transgenic mice deficient in VEGFR-1 sign

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El-Sammak, Hadil, Bingyuan Yang, Stefan Guenther, Wenbiao Chen, Rubén Marín-Juez, and Didier Y. R. Stainier. "A Vegfc-Emilin2a-Cxcl8a Signaling Axis Required for Zebrafish Cardiac Regeneration." Circulation Research 130, no. 7 (2022): 1014–29. http://dx.doi.org/10.1161/circresaha.121.319929.

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Background: Ischemic heart disease following the obstruction of coronary vessels leads to the death of cardiac tissue and the formation of a fibrotic scar. In contrast to adult mammals, zebrafish can regenerate their heart after injury, enabling the study of the underlying mechanisms. One of the earliest responses following cardiac injury in adult zebrafish is coronary revascularization. Defects in this process lead to impaired cardiomyocyte repopulation and scarring. Hence, identifying and investigating factors that promote coronary revascularization holds great therapeutic potential. Methods

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Litke, Christian, Hilmar Bading, and Daniela Mauceri. "Histone deacetylase 4 shapes neuronal morphology via a mechanism involving regulation of expression of vascular endothelial growth factor D." Journal of Biological Chemistry 293, no. 21 (2018): 8196–207. http://dx.doi.org/10.1074/jbc.ra117.001613.

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Nucleo-cytoplasmic shuttling of class IIa histone deacetylases (i.e. HDAC4, -5, -7, and -9) is a synaptic activity- and nuclear calcium–dependent mechanism important for epigenetic regulation of signal-regulated gene expression in hippocampal neurons. HDAC4 in particular has been linked to the regulation of genes important for both synaptic structure and plasticity. Here, using a constitutively nuclear-localized, dominant-active variant of HDAC4 (HDAC4 3SA), we demonstrate that HDAC4 accumulation in the nucleus severely reduces both the length and complexity of dendrites of cultured mature hip

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Astin, J. W., M. J. L. Haggerty, K. S. Okuda, et al. "Vegfd can compensate for loss of Vegfc in zebrafish facial lymphatic sprouting." Development 141, no. 13 (2014): 2680–90. http://dx.doi.org/10.1242/dev.106591.

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Gao, Chaoqun, Jie Zhu, Qiu Qin, Xiaorong Yang, Yanfei Jiang, and Jinan Zhang. "The Relationship between VEGFC Gene Polymorphisms and Autoimmune Thyroiditis." BioMed Research International 2022 (July 12, 2022): 1–8. http://dx.doi.org/10.1155/2022/2603519.

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Background. Autoimmune thyroid diseases (AITDs), representative autoimmune diseases, mainly consist of Graves’ disease (GD) and Hashimoto’s thyroiditis (HT). In this passage, we investigated the association between vascular endothelial growth factor C (VEGFC) gene polymorphisms and AITDs. Methods. A total of 1084 patients with AITDs and 794 healthy controls were tested for VEGFC gene genotypes in four single nucleotide polymorphisms (SNPs) by high-throughput sequencing, and the correlation between VEGFC gene polymorphisms and AITDs was statistically analyzed. Results. The genotype distribution

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Verbiest, Annelies, Benoit Beuselinck, Gabrielle Couchy, et al. "Metastatic clear cell renal cell carcinoma: Proangiogenic gene expression and outcome on sunitinib." Journal of Clinical Oncology 35, no. 15_suppl (2017): e16085-e16085. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e16085.

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e16085 Background: Clear cell renal cell carcinomas (ccRCC) are hypervascular tumors that respond to vascular endothelial growth factor receptor (VEGFR) inhibitors such as sunitinib. They can be divided into 4 mRNA-expression based subgroups (ccrcc 1-4) with different outcomes on sunitinib. We hypothesized that the expression of proangiogenic genes is predictive for response to sunitinib. Methods: Retrospective series of metastatic ccRCC-patients treated with sunitinib as first line targeted therapy (n = 104). We studied expression of genes involved in angiogenesis and the immune-suppressive m

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Rei, Nádia, Cláudia A. Valente, Sandra H. Vaz, Miguel Farinha-Ferreira, Joaquim A. Ribeiro, and Ana M. Sebastião. "Changes in adenosine receptors and neurotrophic factors in the SOD1G93A mouse model of amyotrophic lateral sclerosis: Modulation by chronic caffeine." PLOS ONE 17, no. 12 (2022): e0272104. http://dx.doi.org/10.1371/journal.pone.0272104.

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Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of corticospinal tract motor neurons. Previous studies showed that adenosine-mediated neuromodulation is disturbed in ALS and that vascular endothelial growth factor (VEGF) has a neuroprotective function in ALS mouse models. We evaluated how adenosine (A1R and A2AR) and VEGF (VEGFA, VEGFB, VEGFR-1 and VEGFR-2) system markers are altered in the cortex and spinal cord of pre-symptomatic and symptomatic SOD1G93A mice. We then assessed if/how chronic treatment of SOD1G93A mice with a widely consumed adenosine rece

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Frantsiyants, Elena M., Oleg I. Kit, Irina V. Kaplieva, et al. "Role of angiogenesis factors in formation of metastatic niches." Journal of Clinical Oncology 37, no. 15_suppl (2019): e15534-e15534. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e15534.

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e15534 Background: A metastatic niche indicates a particular location with a specific cell type, epidermal-mesenchymal transition proteins and diffuse signals that are necessary for the growth of metastases. The purpose of the study was to determine levels of VEGFs, their receptors and TGFβ1 in tissues of gastric cancer (GC) and its metastatic niches: the peritoneum and omentum. Methods: The main group included 21 patients with metastatic GC T3-4аN0-3M1; comparison group – 17 non-cancer patients. Levels of VEGFA, VEGFC, sVEGFR1, sVEGFR3 and TGFβ1 in tissues were determined by standard ELISA me

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Yu, Huapeng, Cuixia Xu, and Qirong Li. "Clinical Efficacy and Safety of Tumor Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy for Ovarian Cancer." Evidence-Based Complementary and Alternative Medicine 2023 (April 12, 2023): 1–8. http://dx.doi.org/10.1155/2023/6412679.

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Objective. To assess the clinical efficacy and safety of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) for ovarian cancer. Methods. From April 2018 to November 2021, 66 patients with ovarian cancer were admitted to our hospital and randomly allocated to undergo intravenous chemotherapy following CRS (the observation group) or CRS with HIPEC (the experimental group) using a parallel randomized technique, with 33 cases in each group. Clinical effectiveness, intraoperative and postoperative recovery, VEGF level, T-lymphocyte subpopulation cell level, adverse e

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Zalewski, Daniel, Paulina Chmiel, Przemysław Kołodziej, et al. "Dysregulations of Key Regulators of Angiogenesis and Inflammation in Abdominal Aortic Aneurysm." International Journal of Molecular Sciences 24, no. 15 (2023): 12087. http://dx.doi.org/10.3390/ijms241512087.

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Abdominal aortic aneurysm (AAA) is a chronic vascular disease caused by localized weakening and broadening of the abdominal aorta. AAA is a clearly underdiagnosed disease and is burdened with a high mortality rate (65–85%) from AAA rupture. Studies indicate that abnormal regulation of angiogenesis and inflammation contributes to progression and onset of this disease; however, dysregulations in the molecular pathways associated with this disease are not yet fully explained. Therefore, in our study, we aimed to identify dysregulations in the key regulators of angiogenesis and inflammation in pat

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Pamies Corts, A., D. Llop, D. Ibarretxe, et al. "AB0053 ANGIOPOIETIN-2, VEGFA, VEGFC, VEGFD, EGF, PLGF AND HB-EGF ARE GROWTH FACTORS ASSOCIATED WITH SUBCLINICAL ARTERIOSCLEROSIS IN A COHORT OF PATIENTS WITH RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1205.2–1206. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4465.

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BackgroundPatients with rheumatoid arthritis (RA) present increased risk of cardiovascular (CV) disease compared to the general population. Moreover, CV risk factors that have causal relationship with atherosclerosis do not seem to fully explain the accelerated process that they exhibit[1]. Over the years, several serum growth factors have been associated with atherosclerosis and some of them have been targeted as potential immunotherapy targets for the treatment of CV disease[2,3]. However, very few studies have studied these associations in RA patients.ObjectivesWe evaluated the association

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