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1

Cerri, G., H. Shimazu, M. A. Maier, and R. N. Lemon. "Facilitation From Ventral Premotor Cortex of Primary Motor Cortex Outputs to Macaque Hand Muscles." Journal of Neurophysiology 90, no. 2 (2003): 832–42. http://dx.doi.org/10.1152/jn.01026.2002.

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We demonstrate that in the macaque monkey there is robust, short-latency facilitation by ventral premotor cortex (area F5) of motor outputs from primary motor cortex (M1) to contralateral intrinsic hand muscles. Experiments were carried out on two adult macaques under light sedation (ketamine plus medetomidine HCl). Facilitation of hand muscle electromyograms (EMG) was tested using arrays of fine intracortical microwires implanted, respectively, in the wrist/digit motor representations of F5 and M1, which were identified by previous mapping with intracortical microstimulation. Single pulses (7
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Murata, Akira, Luciano Fadiga, Leonardo Fogassi, Vittorio Gallese, Vassilis Raos, and Giacomo Rizzolatti. "Object Representation in the Ventral Premotor Cortex (Area F5) of the Monkey." Journal of Neurophysiology 78, no. 4 (1997): 2226–30. http://dx.doi.org/10.1152/jn.1997.78.4.2226.

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Murata, Akira, Luciano Fadiga, Leonardo Fogassi, Vittorio Gallese, Vassilis Raos, and Giacomo Rizzolatti. Object representation in the ventral premotor cortex (area F5) of the monkey. J. Neurophysiol. 78: 2226–2230, 1997. Visual and motor properties of single neurons of monkey ventral premotor cortex (area F5) were studied in a behavioral paradigm consisting of four conditions: object grasping in light, object grasping in dark, object fixation, and fixation of a spot of light. The employed objects were six different three-dimensional (3-D) geometric solids. Two main types of neurons were disti
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Theys, Tom, Pierpaolo Pani, Johannes van Loon, Jan Goffin, and Peter Janssen. "Three-dimensional Shape Coding in Grasping Circuits: A Comparison between the Anterior Intraparietal Area and Ventral Premotor Area F5a." Journal of Cognitive Neuroscience 25, no. 3 (2013): 352–64. http://dx.doi.org/10.1162/jocn_a_00332.

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Depth information is necessary for adjusting the hand to the three-dimensional (3-D) shape of an object to grasp it. The transformation of visual information into appropriate distal motor commands is critically dependent on the anterior intraparietal area (AIP) and the ventral premotor cortex (area F5), particularly the F5p sector. Recent studies have demonstrated that both AIP and the F5a sector of the ventral premotor cortex contain neurons that respond selectively to disparity-defined 3-D shape. To investigate the neural coding of 3-D shape and the behavioral role of 3-D shape-selective neu
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Belmalih, Abdelouahed, Elena Borra, Massimo Contini, Marzio Gerbella, Stefano Rozzi, and Giuseppe Luppino. "Multimodal architectonic subdivision of the rostral part (area F5) of the macaque ventral premotor cortex." Journal of Comparative Neurology 512, no. 2 (2009): 183–217. http://dx.doi.org/10.1002/cne.21892.

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5

Maier, Marc A., Peter A. Kirkwood, Thomas Brochier, and Roger N. Lemon. "Responses of single corticospinal neurons to intracortical stimulation of primary motor and premotor cortex in the anesthetized macaque monkey." Journal of Neurophysiology 109, no. 12 (2013): 2982–98. http://dx.doi.org/10.1152/jn.01080.2012.

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The responses of individual primate corticospinal neurons to localized electrical stimulation of primary motor (M1) and of ventral premotor cortex (area F5) are poorly documented. To rectify this and to study interactions between responses from these areas, we recorded corticospinal axons, identified by pyramidal tract stimulation, in the cervical spinal cord of three chloralose-anesthetized macaque monkeys. Single stimuli (≤400 μA) were delivered to the hand area of M1 or F5 through intracortical microwire arrays. Only 14/112 (13%) axons showed responses to M1 stimuli that indicated direct in
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Umilta, M. A., T. Brochier, R. L. Spinks, and R. N. Lemon. "Simultaneous Recording of Macaque Premotor and Primary Motor Cortex Neuronal Populations Reveals Different Functional Contributions to Visuomotor Grasp." Journal of Neurophysiology 98, no. 1 (2007): 488–501. http://dx.doi.org/10.1152/jn.01094.2006.

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To understand the relative contributions of primary motor cortex (M1) and area F5 of the ventral premotor cortex (PMv) to visually guided grasp, we made simultaneous multiple electrode recordings from the hand representations of these two areas in two adult macaque monkeys. The monkeys were trained to fixate, reach out and grasp one of six objects presented in a pseudorandom order. In M1 326 task-related neurons, 104 of which were identified as pyramidal tract neurons, and 138 F5 neurons were analyzed as separate populations. All three populations showed activity that distinguished the six obj
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Kraskov, A., R. Philipp, S. Waldert, G. Vigneswaran, M. M. Quallo, and R. N. Lemon. "Corticospinal mirror neurons." Philosophical Transactions of the Royal Society B: Biological Sciences 369, no. 1644 (2014): 20130174. http://dx.doi.org/10.1098/rstb.2013.0174.

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Here, we report the properties of neurons with mirror-like characteristics that were identified as pyramidal tract neurons (PTNs) and recorded in the ventral premotor cortex (area F5) and primary motor cortex (M1) of three macaque monkeys. We analysed the neurons’ discharge while the monkeys performed active grasp of either food or an object, and also while they observed an experimenter carrying out a similar range of grasps. A considerable proportion of tested PTNs showed clear mirror-like properties (52% F5 and 58% M1). Some PTNs exhibited ‘classical’ mirror neuron properties, increasing act
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8

Ferrari, Pier Francesco, Stefano Rozzi, and Leonardo Fogassi. "Mirror Neurons Responding to Observation of Actions Made with Tools in Monkey Ventral Premotor Cortex." Journal of Cognitive Neuroscience 17, no. 2 (2005): 212–26. http://dx.doi.org/10.1162/0898929053124910.

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In the present study, we describe a new type of visuomotor neurons, named tool-responding mirror neurons, which are found in the lateral sector of monkey ventral premotor area F5. Tool-responding mirror neurons discharge when the monkey observes actions performed by an experimenter with a tool (a stick or a pair of pliers). This response is stronger than that obtained when the monkey observes a similar action made with a biological effector (the hand or the mouth). These neurons respond also when the monkey executes actions with both the hand and the mouth. The visual and the motor responses o
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9

Oosterhof, Nikolaas N., Steven P. Tipper, and Paul E. Downing. "Viewpoint (In)dependence of Action Representations: An MVPA Study." Journal of Cognitive Neuroscience 24, no. 4 (2012): 975–89. http://dx.doi.org/10.1162/jocn_a_00195.

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The discovery of mirror neurons—neurons that code specific actions both when executed and observed—in area F5 of the macaque provides a potential neural mechanism underlying action understanding. To date, neuroimaging evidence for similar coding of specific actions across the visual and motor modalities in human ventral premotor cortex (PMv)—the putative homologue of macaque F5—is limited to the case of actions observed from a first-person perspective. However, it is the third-person perspective that figures centrally in our understanding of the actions and intentions of others. To address thi
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Luppino, G., Akira Murata, Paolo Govoni, and Massimo Matelli. "Largely segregated parietofrontal connections linking rostral intraparietal cortex (areas AIP and VIP) and the ventral premotor cortex (areas F5 and F4)." Experimental Brain Research 128, no. 1-2 (1999): 181–87. http://dx.doi.org/10.1007/s002210050833.

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11

Coudé, Gino, Giulia Toschi, Fabrizia Festante, Marco Bimbi, James Bonaiuto, and Pier Francesco Ferrari. "Grasping Neurons in the Ventral Premotor Cortex of Macaques Are Modulated by Social Goals." Journal of Cognitive Neuroscience 31, no. 2 (2019): 299–313. http://dx.doi.org/10.1162/jocn_a_01353.

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Although it is established that F5 neurons can distinguish between nonsocial goals such as bringing food to the mouth for eating or placing it in a container, it is not clear whether they discriminate between social and nonsocial goals. Here, we recorded single-unit activity in the ventral premotor cortex of two female macaques and used a simple reach-to-grasp motor task in which a monkey grasped an object with a precision grip in three conditions, which only differed in terms of their final goal, that is, a subsequent motor act that was either social (placing in the experimenter's hand [“Hand
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12

Fujii, N., H. Mushiake, and J. Tanji. "An oculomotor representation area within the ventral premotor cortex." Proceedings of the National Academy of Sciences 95, no. 20 (1998): 12034–37. http://dx.doi.org/10.1073/pnas.95.20.12034.

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13

Papadourakis, Vassilis, and Vassilis Raos. "Neurons in the Macaque Dorsal Premotor Cortex Respond to Execution and Observation of Actions." Cerebral Cortex 29, no. 10 (2018): 4223–37. http://dx.doi.org/10.1093/cercor/bhy304.

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Abstract We identified neurons in dorsal premotor cortex (PMd) of the macaque brain that respond during execution and observation of reaching-to-grasp actions, thus fulfilling the mirror neuron (MirN) criterion. During observation, the percentage of grip-selective MirNs in PMd and area F5 were comparable, and the selectivity indices in the two areas were similar. During execution, F5-MirNs were more selective than PMd–MirNs for grip, which was reflected in the higher selectivity indices in F5 than in PMd. PMd displayed grip-related information earlier than F5 during both conditions. In both ar
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14

Schubotz, Ricarda I., and Christian J. Fiebach. "Integrative Models of Broca's Area and the Ventral Premotor Cortex." Cortex 42, no. 4 (2006): 461–63. http://dx.doi.org/10.1016/s0010-9452(08)70377-0.

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15

Raos, Vassilis, Maria-Alessandra Umiltá, Akira Murata, Leonardo Fogassi, and Vittorio Gallese. "Functional Properties of Grasping-Related Neurons in the Ventral Premotor Area F5 of the Macaque Monkey." Journal of Neurophysiology 95, no. 2 (2006): 709–29. http://dx.doi.org/10.1152/jn.00463.2005.

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We investigated the motor and visual properties of F5 grasping neurons, using a controlled paradigm that allows the study of the neuronal discharge during both observation and grasping of many different three-dimensional objects with and without visual guidance. All neurons displayed a preference for grasping of an object or a set of objects. The same preference was maintained when grasping was performed in the dark without visual feedback. In addition to the motor-related discharge, about half of the neurons also responded to the presentation of an object or a set of objects, even when a gras
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Gerbella, Marzio, Abdelouahed Belmalih, Elena Borra, Stefano Rozzi, and Giuseppe Luppino. "Cortical connections of the anterior (F5a) subdivision of the macaque ventral premotor area F5." Brain Structure and Function 216, no. 1 (2010): 43–65. http://dx.doi.org/10.1007/s00429-010-0293-6.

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17

Pomper, Joern K., Silvia Spadacenta, Friedemann Bunjes, Daniel Arnstein, Martin A. Giese, and Peter Thier. "Representation of the observer’s predicted outcome value in mirror and nonmirror neurons of macaque F5 ventral premotor cortex." Journal of Neurophysiology 124, no. 3 (2020): 941–61. http://dx.doi.org/10.1152/jn.00234.2020.

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Both the populations of F5 mirror neurons and nonmirror neurons represent the predicted value of an outcome resulting from the observation of a grasping action. Value-dependent motivation, arousal, and attention directed at the observed action do not provide a better explanation for this representation. The population activity’s metric suggests an optimal scaling of value representation to task setting.
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18

Montani, Fernando, Andriy Oliynyk, and Luciano Fadiga. "Superlinear Summation of Information in Premotor Neuron Pairs." International Journal of Neural Systems 27, no. 02 (2016): 1650009. http://dx.doi.org/10.1142/s012906571650009x.

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Whether premotor/motor neurons encode information in terms of spiking frequency or by their relative time of firing, which may display synchronization, is still undetermined. To address this issue, we used an information theory approach to analyze neuronal responses recorded in the premotor (area F5) and primary motor (area F1) cortices of macaque monkeys under four different conditions of visual feedback during hand grasping. To evaluate the sensitivity of spike timing correlation between single neurons, we investigated the stimulus dependent synchronization in our population of pairs. We fir
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19

Frost, S. B., S. Barbay, K. M. Friel, E. J. Plautz, and R. J. Nudo. "Reorganization of Remote Cortical Regions After Ischemic Brain Injury: A Potential Substrate for Stroke Recovery." Journal of Neurophysiology 89, no. 6 (2003): 3205–14. http://dx.doi.org/10.1152/jn.01143.2002.

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Although recent neurological research has shed light on the brain's mechanisms of self-repair after stroke, the role that intact tissue plays in recovery is still obscure. To explore these mechanisms further, we used microelectrode stimulation techniques to examine functional remodeling in cerebral cortex after an ischemic infarct in the hand representation of primary motor cortex in five adult squirrel monkeys. Hand preference and the motor skill of both hands were assessed periodically on a pellet retrieval task for 3 mo postinfarct. Initial postinfarct motor impairment of the contralateral
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20

Koelsch, Stefan. "Significance of Broca's Area and Ventral Premotor Cortex for Music-Syntactic Processing." Cortex 42, no. 4 (2006): 518–20. http://dx.doi.org/10.1016/s0010-9452(08)70390-3.

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21

Caggiano, Vittorio, Leonardo Fogassi, Giacomo Rizzolatti, et al. "View-Based Encoding of Actions in Mirror Neurons of Area F5 in Macaque Premotor Cortex." Current Biology 21, no. 2 (2011): 144–48. http://dx.doi.org/10.1016/j.cub.2010.12.022.

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22

Arbib, Michael A. "From visual affordances in monkey parietal cortex to hippocampo–parietal interactions underlying rat navigation." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 352, no. 1360 (1997): 1429–36. http://dx.doi.org/10.1098/rstb.1997.0129.

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This paper explores the hypothesis that various subregions (but by no means all) of the posterior parietal cortex are specialized to process visual information to extract a variety of affordances for behaviour. Two biologically based models of regions of the posterior parietal cortex of the monkey are introduced. The model of the lateral intraparietal area (LIP) emphasizes its roles in dynamic remapping of the representation of targets during a double saccade task, and in combining stored, updated input with current visual input. The model of the anterior intraparietal area (AIP) addresses par
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Friederici, Angela D. "Broca's Area and the Ventral Premotor Cortex in Language: Functional Differentiation and Specificity." Cortex 42, no. 4 (2006): 472–75. http://dx.doi.org/10.1016/s0010-9452(08)70380-0.

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24

Fink, Gereon R., Richard S. J. Frackowiak, Uwe Pietrzyk, and Richard E. Passingham. "Multiple Nonprimary Motor Areas in the Human Cortex." Journal of Neurophysiology 77, no. 4 (1997): 2164–74. http://dx.doi.org/10.1152/jn.1997.77.4.2164.

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Fink, Gereon R., Richard S. J. Frackowiak, Uwe Pietrzyk, and Richard E. Passingham. Multiple nonprimary motor areas in the human cortex. J. Neurophysiol. 77: 2164–2174, 1997. We measured the distribution of regional cerebral blood flow with positron emission tomography while three subjects moved their hand, shoulder, or leg. The images were coregistered with each individual's anatomic magnetic resonance scans. The data were analyzed for each individual to avoid intersubject averaging and so to preserve individual gyral anatomy. Instead of inspecting all pixels, we prospectively restricted the
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Wuerger, Sophie M., Laura Parkes, Penelope A. Lewis, Alex Crocker-Buque, Roland Rutschmann, and Georg F. Meyer. "Premotor Cortex Is Sensitive to Auditory–Visual Congruence for Biological Motion." Journal of Cognitive Neuroscience 24, no. 3 (2012): 575–87. http://dx.doi.org/10.1162/jocn_a_00173.

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The auditory and visual perception systems have developed special processing strategies for ecologically valid motion stimuli, utilizing some of the statistical properties of the real world. A well-known example is the perception of biological motion, for example, the perception of a human walker. The aim of the current study was to identify the cortical network involved in the integration of auditory and visual biological motion signals. We first determined the cortical regions of auditory and visual coactivation (Experiment 1); a conjunction analysis based on unimodal brain activations ident
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Carpaneto, J., M. A. Umiltà, L. Fogassi, et al. "Decoding the activity of grasping neurons recorded from the ventral premotor area F5 of the macaque monkey." Neuroscience 188 (August 2011): 80–94. http://dx.doi.org/10.1016/j.neuroscience.2011.04.062.

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27

Cardini, Flavia, Marcello Costantini, Gaspare Galati, Gian Luca Romani, Elisabetta Làdavas, and Andrea Serino. "Viewing One's Own Face Being Touched Modulates Tactile Perception: An fMRI Study." Journal of Cognitive Neuroscience 23, no. 3 (2011): 503–13. http://dx.doi.org/10.1162/jocn.2010.21484.

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The perception of tactile stimuli on the face is modulated if subjects concurrently observe a face being touched; this effect, termed visual remapping of touch (VRT), is maximum for observing one's own face. In the present fMRI study, we investigated the neural basis of the VRT effect. Participants in the scanner received tactile stimuli, near the perceptual threshold, on their right, left, or both cheeks. Concurrently, they watched movies depicting their own face, another person's face, or a ball that could be touched or only approached by human fingers. Participants were requested to disting
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28

Goulas, Alexandros, Peter Stiers, R. Matthew Hutchison, Stefan Everling, Michael Petrides, and Daniel S. Margulies. "Intrinsic functional architecture of the macaque dorsal and ventral lateral frontal cortex." Journal of Neurophysiology 117, no. 3 (2017): 1084–99. http://dx.doi.org/10.1152/jn.00486.2016.

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Investigations of the cellular and connectional organization of the lateral frontal cortex (LFC) of the macaque monkey provide indispensable knowledge for generating hypotheses about the human LFC. However, despite numerous investigations, there are still debates on the organization of this brain region. In vivo neuroimaging techniques such as resting-state functional magnetic resonance imaging (fMRI) can be used to define the functional circuitry of brain areas, producing results largely consistent with gold-standard invasive tract-tracing techniques and offering the opportunity for cross-spe
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Côté, Sandrine L., Guillaume Elgbeili, Stephan Quessy, and Numa Dancause. "Modulatory effects of the supplementary motor area on primary motor cortex outputs." Journal of Neurophysiology 123, no. 1 (2020): 407–19. http://dx.doi.org/10.1152/jn.00391.2019.

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Premotor areas of primates are specialized cortical regions that can contribute to hand movements by modulating the outputs of the primary motor cortex (M1). The goal of the present work was to study how the supplementary motor area (SMA) located within the same hemisphere [i.e., ipsilateral SMA (iSMA)] or the opposite hemisphere [i.e., contralateral (cSMA)] modulate the outputs of M1. We used paired-pulse protocols with intracortical stimulations in sedated capuchin monkeys. A conditioning stimulus in iSMA or cSMA was delivered simultaneously or before a test stimulus in M1 with different int
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Deiber, M. P., S. P. Wise, M. Honda, M. J. Catalan, J. Grafman, and M. Hallett. "Frontal and Parietal Networks for Conditional Motor Learning: A Positron Emission Tomography Study." Journal of Neurophysiology 78, no. 2 (1997): 977–91. http://dx.doi.org/10.1152/jn.1997.78.2.977.

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Deiber, M.-P., S. P. Wise, M. Honda, M. J. Catalan, J. Grafman, and M. Hallett. Frontal and parietal networks for conditional motor learning: a positron emission tomography study. J. Neurophysiol. 78: 977–991, 1997. Studies on nonhuman primates show that the premotor (PM) and prefrontal (PF) areas are necessary for the arbitrary mapping of a set of stimuli onto a set of responses. However, positron emission tomography (PET) measurements of regional cerebral blood flow (rCBF) in human subjects have failed to reveal the predicted rCBF changes during such behavior. We therefore studied rCBF while
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31

Eichert, Nicole, Daniel Papp, Rogier B. Mars, and Kate E. Watkins. "Mapping Human Laryngeal Motor Cortex during Vocalization." Cerebral Cortex 30, no. 12 (2020): 6254–69. http://dx.doi.org/10.1093/cercor/bhaa182.

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Abstract The representations of the articulators involved in human speech production are organized somatotopically in primary motor cortex. The neural representation of the larynx, however, remains debated. Both a dorsal and a ventral larynx representation have been previously described. It is unknown, however, whether both representations are located in primary motor cortex. Here, we mapped the motor representations of the human larynx using functional magnetic resonance imaging and characterized the cortical microstructure underlying the activated regions. We isolated brain activity related
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32

Urgesi, Cosimo, Matteo Candidi, Silvio Ionta, and Salvatore M. Aglioti. "Representation of body identity and body actions in extrastriate body area and ventral premotor cortex." Nature Neuroscience 10, no. 1 (2006): 30–31. http://dx.doi.org/10.1038/nn1815.

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Paulesu, E., D. Perani, V. Blasi, et al. "A Functional-Anatomical Model for Lipreading." Journal of Neurophysiology 90, no. 3 (2003): 2005–13. http://dx.doi.org/10.1152/jn.00926.2002.

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Regional cerebral blood flow (rCBF) PET scans were used to study the physiological bases of lipreading, a natural skill of extracting language from mouth movements, which contributes to speech perception in everyday life. Viewing connected mouth movements that could not be lexically identified and that evoke perception of isolated speech sounds (nonlexical lipreading) was associated with bilateral activation of the auditory association cortex around Wernicke's area, of left dorsal premotor cortex, and left opercular-premotor division of the left inferior frontal gyrus (Broca's area). The suppl
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Jacobs, Stéphane, Claudia Danielmeier, and Scott H. Frey. "Human Anterior Intraparietal and Ventral Premotor Cortices Support Representations of Grasping with the Hand or a Novel Tool." Journal of Cognitive Neuroscience 22, no. 11 (2010): 2594–608. http://dx.doi.org/10.1162/jocn.2009.21372.

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Humans display a remarkable capacity to use tools instead of their biological effectors. Yet, little is known about the mechanisms that support these behaviors. Here, participants learned to grasp objects, appearing in a variety of orientations, with a novel, handheld mechanical tool. Following training, psychophysical functions relating grip preferences (i.e., pronated vs. supinated) to stimulus orientations indicate a reliance on distinct, effector-specific internal representations when planning grasping actions on the basis of the tool versus the hands. Accompanying fMRI data show that grip
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Benzagmout, Mohammed, Peggy Gatignol, and Hugues Duffau. "RESECTION OF WORLD HEALTH ORGANIZATION GRADE II GLIOMAS INVOLVING BROCA'S AREA." Neurosurgery 61, no. 4 (2007): 741–53. http://dx.doi.org/10.1227/01.neu.0000298902.69473.77.

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Abstract OBJECTIVE Advances in functional mapping have enabled us to extend the indications of surgery for low-grade gliomas (LGGs) within eloquent regions. However, to our knowledge, no study has been specifically dedicated to the resection of LGGs within Broca's area. We report the first surgical series of LGGs involving this area by focusing on methodological and functional considerations. METHODS Seven patients harboring an LGG in Broca's area (revealed by partial seizures) had a language functional magnetic resonance imaging scan and then underwent operation while awake using intrasurgica
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Bonini, Luca, Francesca Ugolotti Serventi, Stefania Bruni, et al. "Selectivity for grip type and action goal in macaque inferior parietal and ventral premotor grasping neurons." Journal of Neurophysiology 108, no. 6 (2012): 1607–19. http://dx.doi.org/10.1152/jn.01158.2011.

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Grasping objects requires the selection of specific grip postures in relation to the objects' physical properties. Furthermore, grasping acts can be embedded in actions aimed at different goals, depending on the context in which the action is performed. Here we assessed whether information on grip and action type integrate at the single-neuron level within the parieto-frontal motor system. For this purpose, we trained three monkeys to perform simple grasp-to-eat and grasp-to-place actions, depending on contextual cues, in which different grip types were required in relation to target features.
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Króliczak, G., T. D. McAdam, D. J. Quinlan, and J. C. Culham. "The Human Dorsal Stream Adapts to Real Actions and 3D Shape Processing: A Functional Magnetic Resonance Imaging Study." Journal of Neurophysiology 100, no. 5 (2008): 2627–39. http://dx.doi.org/10.1152/jn.01376.2007.

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We tested whether the control of real actions in an ever-changing environment would show any dependence on prior actions elicited by instructional cues a few seconds before. To this end, adaptation of the functional magnetic resonance imaging signal was measured while human participants sequentially grasped three-dimensional objects in an event-related design, using grasps oriented along the same or a different axis of either the same or a different object shape. We found that the bilateral anterior intraparietal sulcus, an area previously linked to the control of visually guided grasping, alo
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Verstynen, Timothy, Kevin Jarbo, Sudhir Pathak, and Walter Schneider. "In Vivo Mapping of Microstructural Somatotopies in the Human Corticospinal Pathways." Journal of Neurophysiology 105, no. 1 (2011): 336–46. http://dx.doi.org/10.1152/jn.00698.2010.

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The human corticospinal pathway is organized in a body-centric (i.e., somatotopic) manner that begins in cortical cell bodies and is maintained in the axons as they project through the midbrain on their way to spinal motor neurons. The subcortical segment of this somatotopy has been described using histological methods on non-human primates but only coarsely validated from lesion studies in human patient populations. Using high definition fiber tracking (HDFT) techniques, we set out to provide the first in vivo quantitative description of the midbrain somatotopy of corticospinal fibers in huma
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39

Vaillancourt, David E., Keith R. Thulborn, and Daniel M. Corcos. "Neural Basis for the Processes That Underlie Visually Guided and Internally Guided Force Control in Humans." Journal of Neurophysiology 90, no. 5 (2003): 3330–40. http://dx.doi.org/10.1152/jn.00394.2003.

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Despite an intricate understanding of the neural mechanisms underlying visual and motor systems, it is not completely understood in which brain regions humans transfer visual information into motor commands. Furthermore, in the absence of visual information, the retrieval process for motor memory information remains unclear. We report an investigation where visuomotor and motor memory processes were separated from only visual and only motor activation. Subjects produced precision grip force during a functional MRI (fMRI) study that included four conditions: rest, grip force with visual feedbac
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Suminski, Aaron J., Philip Mardoum, Timothy P. Lillicrap, and Nicholas G. Hatsopoulos. "Temporal evolution of both premotor and motor cortical tuning properties reflect changes in limb biomechanics." Journal of Neurophysiology 113, no. 7 (2015): 2812–23. http://dx.doi.org/10.1152/jn.00486.2014.

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A prevailing theory in the cortical control of limb movement posits that premotor cortex initiates a high-level motor plan that is transformed by the primary motor cortex (MI) into a low-level motor command to be executed. This theory implies that the premotor cortex is shielded from the motor periphery, and therefore, its activity should not represent the low-level features of movement. Contrary to this theory, we show that both dorsal (PMd) and ventral premotor (PMv) cortexes exhibit population-level tuning properties that reflect the biomechanical properties of the periphery similar to thos
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Ehrsson, H. Henrik, Stefan Geyer, and Eiichi Naito. "Imagery of Voluntary Movement of Fingers, Toes, and Tongue Activates Corresponding Body-Part-Specific Motor Representations." Journal of Neurophysiology 90, no. 5 (2003): 3304–16. http://dx.doi.org/10.1152/jn.01113.2002.

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We investigate whether imagery of voluntary movements of different body parts activates somatotopical sections of the human motor cortices. We used functional magnetic resonance imaging to detect the cortical activity when 7 healthy subjects imagine performing repetitive (0.5-Hz) flexion/extension movements of the right fingers or right toes, or horizontal movements of the tongue. We also collected functional images when the subjects actually executed these movements and used these data to define somatotopical representations in the motor areas. In this study, we relate the functional activati
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Stephan, K. M., G. R. Fink, R. E. Passingham, et al. "Functional anatomy of the mental representation of upper extremity movements in healthy subjects." Journal of Neurophysiology 73, no. 1 (1995): 373–86. http://dx.doi.org/10.1152/jn.1995.73.1.373.

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1. Differences in the distribution of relative regional cerebral blood flow during motor imagery and execution of a joy-stick movement were investigated in six healthy volunteers with the use of positron emission tomography (PET). Both tasks were compared with a common baseline condition, motor preparation, and with each other. Data were analyzed for individual subjects and for the group, and areas of significant flow differences were related to anatomy by magnetic resonance imaging (MRI). 2. Imagining movements activated a number of frontal and parietal regions: medial and lateral premotor ar
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Ishida, Hiroaki, Katsumi Nakajima, Masahiko Inase, and Akira Murata. "Shared Mapping of Own and Others' Bodies in Visuotactile Bimodal Area of Monkey Parietal Cortex." Journal of Cognitive Neuroscience 22, no. 1 (2010): 83–96. http://dx.doi.org/10.1162/jocn.2009.21185.

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Parietal cortex contributes to body representations by integrating visual and somatosensory inputs. Because mirror neurons in ventral premotor and parietal cortices represent visual images of others' actions on the intrinsic motor representation of the self, this matching system may play important roles in recognizing actions performed by others. However, where and how the brain represents others' bodies and correlates self and other body representations remain unclear. We expected that a population of visuotactile neurons in simian parietal cortex would represent not only own but others' body
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Payoux, Pierre, Philippe Remy, Malika Miloudi, et al. "Contrasting Changes in Cortical Activation Induced by Acute High-Frequency Stimulation within the Globus Pallidus in Parkinson's Disease." Journal of Cerebral Blood Flow & Metabolism 29, no. 2 (2008): 235–43. http://dx.doi.org/10.1038/jcbfm.2008.107.

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Continuous stimulation of the globus pallidus (GP) has been shown to be an effective treatment for Parkinson's disease (PD). We used the fact that the implanted quadripolar leads contain electrodes within the GPi and GPe to investigate the clinical effects of acute high-frequency stimulation applied in these nuclei and changes in regional cerebral blood flow (rCBF) as an index of synaptic activity. In five patients treated by chronic GP stimulation, we compared the effects on PD symptoms and the changes in rCBF at rest and during paced right-hand movements, with and without left GPe or GPi sti
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Yagmurlu, Kaan, Erik H. Middlebrooks, Necmettin Tanriover, and Albert L. Rhoton. "Fiber tracts of the dorsal language stream in the human brain." Journal of Neurosurgery 124, no. 5 (2016): 1396–405. http://dx.doi.org/10.3171/2015.5.jns15455.

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OBJECT The aim of this study was to examine the arcuate (AF) and superior longitudinal fasciculi (SLF), which together form the dorsal language stream, using fiber dissection and diffusion imaging techniques in the human brain. METHODS Twenty-five formalin-fixed brains (50 hemispheres) and 3 adult cadaveric heads, prepared according to the Klingler method, were examined by the fiber dissection technique. The authors’ findings were supported with MR tractography provided by the Human Connectome Project, WU-Minn Consortium. The frequencies of gyral distributions were calculated in segments of th
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Byblow, Winston D., James P. Coxon, Cathy M. Stinear, et al. "Functional Connectivity Between Secondary and Primary Motor Areas Underlying Hand–Foot Coordination." Journal of Neurophysiology 98, no. 1 (2007): 414–22. http://dx.doi.org/10.1152/jn.00325.2007.

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Coincident hand and foot movements are more reliably performed in the same direction than in opposite directions. Using transcranial magnetic stimulation (TMS) to assess motor cortex function, we examined the physiological basis of these movements across three novel experiments. Experiment 1 demonstrated that upper limb corticomotor excitability changed in a way that facilitated isodirectional movements of the hand and foot, during phasic and isometric muscle activation conditions. Experiment 2 demonstrated that motor cortex inhibition was modified with active, but not passive, foot movement i
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Kurata, Kiyoshi, and Eiji Hoshi. "Reacquisition Deficits in Prism Adaptation After Muscimol Microinjection Into the Ventral Premotor Cortex of Monkeys." Journal of Neurophysiology 81, no. 4 (1999): 1927–38. http://dx.doi.org/10.1152/jn.1999.81.4.1927.

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Reacquisition deficits in prism adaptation after muscimol microinjection into the ventral premotor cortex of monkeys. A small amount of muscimol (1 μl; concentration, 5 μg/μl) was injected into the ventral and dorsal premotor cortex areas (PMv and PMd, respectively) of monkeys, which then were required to perform a visually guided reaching task. For the task, the monkeys were required to reach for a target soon after it was presented on a screen. While performing the task, the monkeys’ eyes were covered with left 10°, right 10°, or no wedge prisms, for a block of 50–100 trials. Without the pri
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Grafton, Scott T., Eliot Hazeltine, and Richard Ivry. "Functional Mapping of Sequence Learning in Normal Humans." Journal of Cognitive Neuroscience 7, no. 4 (1995): 497–510. http://dx.doi.org/10.1162/jocn.1995.7.4.497.

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The brain localization of motor sequence learning was studied in normal subjects with positron emission tomography. Subjects performed a serial reaction time (SRT) task by responding to a series of stimuli that occurred at four different spatial positions. The stimulus locations were either determined randomly or according to a 6-element sequence that cycled continuously. The SRT task was performed under two conditions. With attentional interference from a secondary counting task there was no development of awareness of the sequence. Learning-related increases of cerebral blood flow were locat
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Schmidlin, E., T. Brochier, M. A. Maier, P. A. Kirkwood, and R. N. Lemon. "Pronounced Reduction of Digit Motor Responses Evoked from Macaque Ventral Premotor Cortex after Reversible Inactivation of the Primary Motor Cortex Hand Area." Journal of Neuroscience 28, no. 22 (2008): 5772–83. http://dx.doi.org/10.1523/jneurosci.0944-08.2008.

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Hattori, Noriaki, Hiroshi Shibasaki, Lewis Wheaton, Tao Wu, Masao Matsuhashi, and Mark Hallett. "Discrete Parieto-Frontal Functional Connectivity Related to Grasping." Journal of Neurophysiology 101, no. 3 (2009): 1267–82. http://dx.doi.org/10.1152/jn.90249.2008.

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The human inferior parietal lobule (IPL) is known to have neuronal connections with the frontal lobe, and these connections have been shown to be associated with sensorimotor integration to perform various types of movement such as grasping. The function of these anatomical connections has not been fully investigated. We studied the judgment of graspability of objects in an event-related functional MRI study in healthy subjects, and found activation in two different regions within IPL: one in the left dorsal IPL extending to the intraparietal sulcus and the other in the left ventral IPL. The f
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