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1

Moqsith, Abd. "Pandangan Ulama Konservatif dan Ulama Progresif tentang Tafsir Ayat Lâ Ikrâh fî al-Dîn." ISLAMICA: Jurnal Studi Keislaman 8, no. 1 (2014): 219. http://dx.doi.org/10.15642/islamica.2013.8.1.219-240.

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The verse <em>lâ ikrâh fî al-dîn</em> has been one of the most contested verses with regard to its meaning and definition by the ‘<em>ulama</em> (religious scholars) from the past to the present. Basing on this verse, progressive ‘<em>ulama</em> maintain that the idea of freedom of religion introduced by modern society does not contradict the Qur’ân. For them, freedom of religion includes not only freedom to convert to Islam, but also freedom to convert from Islam. This view is rejected by conservative ‘<em>ulama</em> who argue that the meaning of the verse contains only freedom to convert to Islam, not to convert from Islam. If non-Muslims are free to convert to Islam, Muslims are not allowed to convert from Islam. Moreover, there are many ‘<em>ulama</em> who argue that the verse has been abrogated by other tens of verses which enjoin to fight against infidels and polytheists. After the revelation of ‘verses of war’ in the Qur’ân, the verse <em>lâ ikrâh fî al-dîn</em> becomes no longer legally binding.
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2

Editorial Submission, Haworth. "The Verne Weed Living Archive for Progressive Social Work." Journal of Progressive Human Services 6, no. 2 (1995): 95–96. http://dx.doi.org/10.1300/j059v06n02_09.

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3

Abramovitz, Mimi, Terry Mizrahi, and David Klaasen. "The Verne Weed Living Archive for Progressive Social Work." Journal of Progressive Human Services 12, no. 2 (2001): 97–98. http://dx.doi.org/10.1300/j059v12n02_08.

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4

Klaassen, David, Terry Mizrahi, and Mimi Abramovitz. "The Verne Weed Living Archive for Progressive Social Work." Journal of Progressive Human Services 1, no. 2 (1990): 127–29. http://dx.doi.org/10.1300/j059v01n02_09.

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Features Submission, Haworth Continuing. "The Verne Weed Living Archive for Progressive Social Work." Journal of Progressive Human Services 2, no. 2 (1991): 131–33. http://dx.doi.org/10.1300/j059v02n02_10.

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6

Features Submission, Haworth. "The Verne Weed Living Archive for Progressive Social Work." Journal of Progressive Human Services 3, no. 2 (1993): 115–17. http://dx.doi.org/10.1300/j059v03n02_08.

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7

Features Submission, Haworth Continuing. "The Verne Weed Living Archive for Progressive Social Work." Journal of Progressive Human Services 5, no. 1 (1994): 123–25. http://dx.doi.org/10.1300/j059v05n01_11.

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8

Editorial Submission, Haworth. "The Verne Weed Living Archive for Progressive Social Work." Journal of Progressive Human Services 6, no. 1 (1995): 127–29. http://dx.doi.org/10.1300/j059v06n01_10.

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9

Médicis, Anne de, and Pierre Leroux. "Generalized Stirling Numbers, Convolution Formulae and p, q-Analogues." Canadian Journal of Mathematics 47, no. 3 (1995): 474–99. http://dx.doi.org/10.4153/cjm-1995-027-x.

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AbstractIn this paper, we study two generalizations of the Stirling numbers of the first and second kinds, inspired from their combinatorial interpretation in terms of 0-1 tableaux. They are the 𝔄-Stirling numbers and the partial Stirling numbers. In particular, we give a q and a p, q-analogue of convolution formulae for Stirling numbers of the second kind, due to Chen and Verde-Star, and we extend these formulae to Stirling numbers of the first kind. Included in this study are the a, d-progressive Stirlingnumbers, corresponding to 0-1 tableaux with column lengths from an arithmetic progression ﹛a + id﹜i≥0.
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10

Espinosa-Paredes, Gilberto, Raúl Camargo-Camargo, and Alejandro Nuñez-Carrera. "Severe Accident Simulation of the Laguna Verde Nuclear Power Plant." Science and Technology of Nuclear Installations 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/209420.

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The loss-of-coolant accident (LOCA) simulation in the boiling water reactor (BWR) of Laguna Verde Nuclear Power Plant (LVNPP) at 105% of rated power is analyzed in this work. The LVNPP model was developed using RELAP/SCDAPSIM code. The lack of cooling water after the LOCA gets to the LVNPP to melting of the core that exceeds the design basis of the nuclear power plant (NPP) sufficiently to cause failure of structures, materials, and systems that are needed to ensure proper cooling of the reactor core by normal means. Faced with a severe accident, the first response is to maintain the reactor core cooling by any means available, but in order to carry out such an attempt is necessary to understand fully the progression of core damage, since such action has effects that may be decisive in accident progression. The simulation considers a LOCA in the recirculation loop of the reactor with and without cooling water injection. During the progression of core damage, we analyze the cooling water injection at different times and the results show that there are significant differences in the level of core damage and hydrogen production, among other variables analyzed such as maximum surface temperature, fission products released, and debris bed height.
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11

Whitekettle, Richard. "Forensic Zoology: Animal Taxonomy and Rhetorical Persuasion in Psalm l." Vetus Testamentum 58, no. 3 (2008): 404–19. http://dx.doi.org/10.1163/156853308x312672.

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AbstractPs. l 9-11 and 12 refute the Israelite belief that God needed their sacrificial animals by explaining that God already possessed animals. In Ps. l 9-11, the bulls and goats the Israelites sacrifice to God (verse 9) are juxtaposed with four types of animals that God possesses (verses 10-11). The juxtaposition of a sacrificial animal with God's extensive zoological wealth made it clear that God did not need a sacrificial animal. In the broader context of Ps. l 9-12, these four types of animals are the middle elements in a three-part progression of animals: bulls/goats (verse 9) → four types of animals (verses 10-11) → all animals/everything (verse 12). This progression generated a robust grasp and active affirmation of the exhaustive extent of God's zoological wealth, a heightened sense of the inadequacy of a sacrificial animal, and a sense of divine agitation which chastened the Israelites for their misunderstanding of the nature and character of God.
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12

Ghafournia, Nafiseh. "Towards a New Interpretation of Quran 4:34." Hawwa 15, no. 3 (2017): 279–92. http://dx.doi.org/10.1163/15692086-12341309.

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AbstractFor almost fourteen centuries, Muslim men and women believed, or have been led to believe, that beating wives is a permitted act in Islam and the Quran has been used to support this physical violence against women. Permissible violence against women has mainly been justified on the basis of the Quranic verse 4:34. Since its revelation, there has been a long time challenge to explore the real meaning of the verse. The translations and interpretations of this verse have caused much consternation among scholars, including this author. However, important attempts have recently been made to define or interpret the verse. In this study, two different strands of interpretation are explored: patriarchal and egalitarian. While there are many interpretations of the verse, this study focuses only on the works of some of the most renowned scholars and theologians. A critical analysis of different approaches to the interpretation of this verse shows that the contradictions and complexities related to the verse are not inherent in the Quran itself but are rooted in the intentional or unintentional neglect and misuse of the text by authoritative Muslim scholars. This study argues for a more progressive approach to interpreting the verse which is compatible with a holistic comprehension of the text and teaching of Islam.
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Sya'rani, Afifur Rochman. "Through the Lens of Gadamer’s Hermeneutics: In comparison between Amina Wadud’s and Mohammed Talbi’s Interpretations of Q. 4:34." SUHUF 9, no. 2 (2017): 193–214. http://dx.doi.org/10.22548/shf.v9i2.155.

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Most of traditional Muslim exegetes interpret Q. 4:34 in terms of maintaining the superiority of men over women. Some progressive Muslim scholars then insist a contextual approach to the verse to criticize gender inequality. Among some progressive Muslim scholars, this article comparatively examines the interpretations of Amina Wadud and Mohammed Talbi of Q. 4:34. Although both of them propose a contextual reading of the verse, they have different intellectual background, approach and method in interpreting the Qur’ān. The questions are to what extent the similarities and differences of both Wadud’s and Talbi’s interpretation of Q. 4:34 and how far their interpretations reflect their respective intention and perspective? Applying Gadamer’s hermeneutical approach, the article concludes that [1] Both Wadud and Talbi argue that the verse does not establish the superiority of men over women, but acknowledges duties division among married couple; [2] the difference among their interpretations is on the status of relationship among married couple; [3] Wadud’s and Talbi’s interpretations represent their respective hermeneutical situations and the way they define ontologically the nature of interpretation and Qur’anic hermeneutics affect on producing the meanings of the verse.
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Reda, Nevin. "The Qurʾan and Domestic Violence: An Islamic Feminist, Spiritually Integrative Reading of Verse 4:34". International Journal of Practical Theology 23, № 2 (2019): 257–73. http://dx.doi.org/10.1515/ijpt-2018-0058.

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Abstract This paper examines Qurʾan 4:34, also known as the “beating verse,” through an Islamic feminist lens, focusing attention on the importance of spirituality in the contemporary context. It contends that reading the Qurʾan as a spiritual method sheds new light on this verse, changing its interpretation from one that makes allowances for wife-beating to one that provides tangible techniques to combat this phenomenon. The paper examines how the verse introduces both positive and negative intervention strategies to restrain and overcome wife-beating, in conversation with Sufi conceptualizations of the spiritual path and progression from the “animal self” to the self-critical self.
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15

Dorleijn, Gillis. "‘WAS HÄTTEN VERSE VON DIESER DEZENZ ZU FÜRCHTEN’." De Moderne Tijd 1, no. 2 (2017): 204–26. http://dx.doi.org/10.5117/dmt2017.2.006.dorl.

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‘WAS HÄTTEN VERSE VON DIESER DEZENZ ZU FÜRCHTEN’ On homosexuality and poetry Concepts of homosexuality circulate in the societal domain and affect literary culture. The first half of the twentieth century saw an increasing domestication of the public domain regarding homosexual practices. Using three perspectives – text, authorial posture, and reception – and focussing on a specific case, a volume of apparently homo-erotic poetry, this article identifies all kinds of tensions: poems touching on homo-erotic subjects while simultaneously covering them up by complex poetic devices; the poet’s posture invoking homo-erotic icons, yet refusing to be outspoken; a progressive critic reading the volume and struggling to reconcile extra-literary and literary norms.
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16

Trowell, Haydn. "The Aesthetics of Linked-Verse Poetry in Yasunari Kawabata’s 'The Lake'." New Voices in Japanese Studies 12 (August 17, 2020): 44–64. http://dx.doi.org/10.21159/nvjs.12.03.

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The distinctive narrative style exhibited in Japanese author Yasunari Kawabata’s literary works has frequently been associated with the traditional Japanese art of linked-verse poetry (renga). However, the precise compositional nature of these similarities has yet to be thoroughly explored. In this article, I examine two fundamental principles of linked-verse poetry, ‘linking’ (tsukeai) and ‘flow’ (yukiyō), and use these as analytical tools to explore the thematic and narrative structure for which Kawabata’s literary technique is renowned. Considering the first chapter of his 1954 novel The Lake (Mizuumi) as a case study, I identify notable correspondences between linked verse and Kawabata’s prose writing in the form of a qualitative mode of progression characterised by a rich use of sensory and emotive association, and a wave-like sense of rhythm between moments of heightened and reduced expressive and affective intensity. This article uses detailed textual analysis to demonstrate a structural basis for comparing Kawabata’s prose with linked verse, which in turn implies that Kawabata’s narrative style is shaped by conscious aesthetic decisions to draw on linked-verse principles.
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17

Steinman, L. M. "The Gospel of Beauty in the Progressive Era: Reforming American Verse and Values." Journal of American History 99, no. 1 (2012): 331–32. http://dx.doi.org/10.1093/jahist/jas006.

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18

SERGIO, CECILIA, and IRENEIA MELO. "Two remarkable new Riccia (Marchantiales, Ricciaceae) records for the bryophyte flora of Cape Verde Islands, an important biogeographical refuge area." Bryophyte Diversity and Evolution 41, no. 2 (2019): 71–76. http://dx.doi.org/10.11646/bde.41.2.3.

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Recent progresses of knowledge on Riccia diversity in Cape Verde islands are briefly surveyed. The occurrence of two remarkable Riccia species in this archipelago is examined, and their overall distribution is presented. Riccia atropurpurea Sim and R. congoana Steph. are noteworthy liverwort species, here reported for the first time for Cape Verde islands, from specimens collected in Fogo island. Main diagnosing characters and those of related taxa, habitat preferences, illustrations, scanning electron micrographs and updated ranges of the species are presented.
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19

Rinciog, C., K. J. Myrén, M. Aldén, A. Diamantopoulos, and C. LeReun. "An Indirect Treatment Comparison of Cabozantinib Verse Vandetanib in Progressive Medullary Thyroid Cancer (MTC)." Value in Health 17, no. 7 (2014): A616—A617. http://dx.doi.org/10.1016/j.jval.2014.08.2173.

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20

Amadio, Susanna, Chiara Parisi, Cinzia Montilli, Alberto Savio Carrubba, Savina Apolloni, and Cinzia Volonté. "P2Y12Receptor on the Verge of a Neuroinflammatory Breakdown." Mediators of Inflammation 2014 (2014): 1–15. http://dx.doi.org/10.1155/2014/975849.

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In the CNS, neuroinflammation occurring during pathologies as amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) is the consequence of an intricate interplay orchestrated by various cell phenotypes. Among the molecular cues having a role in this process, extracellular nucleotides are responsible for intercellular communication and propagation of inflammatory stimuli. This occurs by binding to several receptor subtypes, defined P2X/P2Y, which are widespread in different tissues and simultaneously localized on multiple cells. For instance, the metabotropic P2Y12subtype is found in the CNS on microglia, affecting activation and chemotaxis, on oligodendrocytes, possessing a hypothesized role in myelination, and on astrocytes. By comparative analysis, we have established here that P2Y12receptor immunolabelled by antibodies against C-terminus or second intracellular loop, is, respectively, distributed and modulated under neuroinflammatory conditions on ramified microglia or myelinated fibers, in primary organotypic cerebellar cultures, tissue slices from rat striatum and cerebellum, spinal cord sections from symptomatic/end stage SOD1-G93A ALS mice, and finally autoptic cortical tissue from progressive MS donors. We suggest that modulation of P2Y12expression might play a dual role as analytic marker of branched/surveillant microglia and demyelinating lesions, thus potentially acquiring a predictive value under neuroinflammatory conditions as those found in ALS and MS.
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21

Silke, John, та Lorraine Ann O’Reilly. "NF-κB and Pancreatic Cancer; Chapter and Verse". Cancers 13, № 18 (2021): 4510. http://dx.doi.org/10.3390/cancers13184510.

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Pancreatic Ductal Adenocarcinoma (PDAC) is one of the world’s most lethal cancers. An increase in occurrence, coupled with, presently limited treatment options, necessitates the pursuit of new therapeutic approaches. Many human cancers, including PDAC are initiated by unresolved inflammation. The transcription factor NF-κB coordinates many signals that drive cellular activation and proliferation during immunity but also those involved in inflammation and autophagy which may instigate tumorigenesis. It is not surprising therefore, that activation of canonical and non-canonical NF-κB pathways is increasingly recognized as an important driver of pancreatic injury, progression to tumorigenesis and drug resistance. Paradoxically, NF-κB dysregulation has also been shown to inhibit pancreatic inflammation and pancreatic cancer, depending on the context. A pro-oncogenic or pro-suppressive role for individual components of the NF-κB pathway appears to be cell type, microenvironment and even stage dependent. This review provides an outline of NF-κB signaling, focusing on the role of the various NF-κB family members in the evolving inflammatory PDAC microenvironment. Finally, we discuss pharmacological control of NF-κB to curb inflammation, focussing on novel anti-cancer agents which reinstate the process of cancer cell death, the Smac mimetics and their pre-clinical and early clinical trials.
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22

Mendes Marques, Nadine B. P. S., Sandra R. Barros, Ana F. Miranda, et al. "Horizontal Gaze Palsy and Progressive Scoliosis With ROBO 3 Mutations in Patients From Cape Verde." Journal of Neuro-Ophthalmology 37, no. 2 (2017): 162–65. http://dx.doi.org/10.1097/wno.0000000000000455.

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Maïzi, Nadia, and François Briens. "Envisager le futur énergétique : des aspirations sociétales aux enjeux techniques." Reflets de la physique, no. 60 (December 2018): 49–51. http://dx.doi.org/10.1051/refdp/201860049.

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Arbitrant entre plusieurs stratégies, voire choix de société, les modèles permettent l’exploration de différents scénarios pour aider à prendre des décisions. Une famille de modèles permet de comparer en détail trois scénarios, respectivement basés sur une croissance dite « verte » de la consommation d’énergie, avec augmentation ou suppression progressive du nucléaire, et sur une décroissance de la consommation d’énergie.
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Miller, Nicholas E. "“Now That It's Just Us Girls”." Feminist Media Histories 4, no. 3 (2018): 205–26. http://dx.doi.org/10.1525/fmh.2018.4.3.205.

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Archie comics have long faced pressures to confront social issues and produce more diverse, inclusive narratives. With Riverdale, the Archie-verse has newly asserted its cultural relevance by simultaneously embracing and revising a nostalgia for earlier Archie comics and characters. This essay explores how the social media paratexts of the Riverdale actors negotiate between the feminist aspirations of the television show and the less progressive politics of earlier Archie comics. Examining these transmedial paratexts, it demonstrates how the beloved Archie characters from earlier comics become newly embodied and vocalized by the actors who portray them in Riverdale, thus inviting comics readers and television fans to embrace a new feminist vision for the Archie-verse while also opening it up to postfeminist critiques.
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Fanego, Teresa. "The Development of Gerunds as Objects of Subject-Control Verbs in English (1400-1760)." Diachronica 13, no. 1 (1996): 29–62. http://dx.doi.org/10.1075/dia.13.1.03fan.

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SUMMARY The article offers an analysis of the development of the gerund, as an alternative to the infinitive, with verbs of subject control, such as attempt, bear, decline, forbear, etc. In the course of the early Modern English period, and particularly during the first half of the 18th century, there is a steady increase in the use of the gerund with most of the verbs in question, and it is suggested that the ultimate reason behind this trend might be related to a parallel rise in the use of -ing forms in other areas of the grammar of English, and, more specifically, to the generalization of the progressive. The process of implementation of the move from infinitival to gerundive complementation is also examined: important factors promoting the diffusion of the gerund are the type of verb, the closeness of the text to an oral mode of expression and the syntactic and semantic environment. RÉSUMÉ Cet article analyse le developpement du gerondif en anglais, en concurrence avec l'infinitif, apres des verbes tels que attempt, bear, decline, for-bear, intend ou like. Au cours de la periode examinee (1400-1760), et en particulier pendant la premiere moitie du XVIIIe siecle, on assiste a une augmentation progressive dans l'emploi du gerondif avec ce type de verbe exprimant une sorte de controle. L'auteur propose qu'un tel accroissement aurait pu, en derniere analyse, se produire avec la generalisation des formes verbales en -ing dans d'autres domaines de la grammaire de l'anglais. Les facteurs qui favorisent la progression du gerondif sont surtout: le type de verbe, le style du texte et l'environnement syntaxique et/ou semantique. ZUSAMMENFASSUNG Der Aufsatz untersucht die Entwicklung des Gerundiums im Englischen als Ersatzform zum Infinitiv nach Verben wie attempt, bear, decline, forbear, intend oder like. Im Laufe der untersuchten Zeitspanne (1400-1760), beson-ders wahrend der ersten Halfte des 18. Jahrhunderts, findet eine standige Zu-nahme des Gerundium-Gebrauchs bei besagten Verbklassen statt, und es liegt nahe, daß diese Zunahme letzten Endes mit der allgemeinen Verbreitung an-derer Verbformen auf -ing in anderen Bereichen der Grammatik des Englischen in Verbindung steht. Die Faktoren, die das Vordringen des Gerundiums begünstigen, sind hauptsachlich die Verbart, der Textstil (formal versus um-gangssprachlich) und das syntaktische und semantische Umfeld.
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Bertrand, Gilles. "Carlo Capra. I progressi della ragione. Vita di Pietro Verri. Bologne, Società editrice il Mulino, 2002, 631 p." Annales. Histoire, Sciences Sociales 59, no. 4 (2004): 882–84. http://dx.doi.org/10.1017/s0395264900019946.

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Mudji, Junior, Jonathan Benhamou, Erick Mwamba-Miaka, Christian Burri, and Johannes Blum. "The Flipside of Eradicating a Disease; Human African Trypanosomiasis in a Woman in Rural Democratic Republic of Congo: A Case Report." Tropical Medicine and Infectious Disease 4, no. 4 (2019): 142. http://dx.doi.org/10.3390/tropicalmed4040142.

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Human African Trypanosomiasis (HAT) is a neglected disease caused by the protozoan parasites Trypanosoma brucei and transmitted by tsetse flies that progresses in two phases. Symptoms in the first phase include fever, headaches, pruritus, lymphadenopathy, and in certain cases, hepato- and splenomegaly. Neurological disorders such as sleep disorder, aggressive behavior, logorrhea, psychotic reactions, and mood changes are signs of the second stage of the disease. Diagnosis follows complex algorithms, including serological testing and microscopy. Our case report illustrates the course of events of a 41-year old woman with sleep disorder, among other neurological symptoms, whose diagnosis was made seven months after the onset of symptoms. The patient had consulted two different hospitals in Kinshasa and was on the verge of being discharged from a third due to negative laboratory test results. This case report highlights the challenges that may arise when a disease is on the verge of eradication.
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Moraes, Larissa Alexandra Cardoso, Terezinha Batista Garcia, and Adônis Moreira. "Limitações nutricionais de mudas de mangostãozeiro." Pesquisa Agropecuária Brasileira 41, no. 7 (2006): 1205–8. http://dx.doi.org/10.1590/s0100-204x2006000700019.

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Este trabalho teve o objetivo de avaliar, por meio da análise foliar, as limitações nutricionais para produção de mudas de mangostãozeiro. Após 12 meses do plantio, em condições de viveiro, com sombreamento no início do desenvolvimento, foi observado amarelecimento progressivo das folhas novas, com diminuição significativa dos teores foliares de Fe e Mn. A aplicação de sulfato de manganês (0,8 mg L-1 de Mn) + 2,5 g L-1 de uréia, via foliar, não ocasionou recuperação da tonalidade verde do limbo foliar. Entretanto, com sulfato de ferro, na concentração de 0,8 mg L-1 de Fe + 2,5 g L-1 de uréia, houve aumento da pigmentação verde nas folhas, o que mostra a baixa eficiência do mangostãozeiro na absorção de Fe, apesar da alta concentração desse nutriente no terriço (223,7 mg dm-3). Isto indica a necessidade de aplicação suplementar de Fe, no substrato ou nas folhas, na fase de viveiro do mangostãozeiro.
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Cateura Bennasser, Pau. "Fiscalidad real y municipal en la Mallorca del siglo XV." Anuario de Estudios Medievales 22, no. 1 (2020): 443. http://dx.doi.org/10.3989/aem.1992.v22.1077.

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Le statut particulier du règne de Majorque dans la Couronne d'Aragon, depuis 1298 jusqu’à 1343, fait montre d'une certaine dualité politique, avec d'évidentes séquelles financières. À partir de 1318, Majorque se verra mêlée aux différents fronts de la politique méditerranéenne des Rois d'Aragon, elle se ressentira d'une hausse progressive de la pression des impôts, qui atteindra un de ses points les plus hauts aux environs de 1331, precisément au moment où commence le changement de conjoncture économique et démographique. La réintégration des Iles à la Couronne d'Aragon, se solde par un appauvrissement notable du patrimoine royal et les conséquences en retomberont sur la Municipalité de Majorque qui se verra obligée d'assumer, en exclusivité, les dépenses de la politique extérieure dont les points culminants se trouvent être Gênes, la Sardaigne et la Castille. L'implantation de la dette publique, solution a des circonstances apparues au milieu du siècle, n'empêchera pas la Municipalité de faire banqueroute en 1372 et 1405, pas plus qu'elle ne permettra d'éviter sa fixation définitive dans l'appareil fiscal du règne.
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Abma, E., L. Cicchelero, H. De Rooster, S. Daminet, and N. N. Sanders. "De hond als kankermodel in de zoektocht naar nieuwe therapeutische alternatieven." Vlaams Diergeneeskundig Tijdschrift 85, no. 3 (2016): 167–70. http://dx.doi.org/10.21825/vdt.v85i3.16344.

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In het kankeronderzoek wordt het knaagdierkankermodel beschouwd als de standaard. De translatie van onderzoeksresultaten van knaagdier naar mens is echter verre van optimaal en het wordt dan ook aanbevolen om de werkzaamheid van nieuwe kankergeneesmiddelen te bevestigen bij hogere diersoorten vooraleer humane studies worden gestart. Honden met spontane kanker zijn de perfecte kandidaten. De histologische, biologische en genetische achtergrond van kanker is beter vergelijkbaar tussen honden en mensen dan tussen knaagdieren en mensen. Tevens zijn de tumorontwikkeling en de interactie tussen de tumor, de gastheer en de micro-omgeving van de tumor analoog aan die bij de mens. De diagnostische en behandelingsmogelijkheden voor de hond zijn overeenkomstig met die voor de mens, terwijl de progressie van kanker bij honden snel genoeg is om binnen een aanvaardbare termijn resultaten te bekomen. Tenslotte is het reglementair gezien makkelijker om honden op te nemen in klinische onderzoeken dan humane patiënten, wat uitgebreide mogelijkheden voor onderzoek verschaft. De hond zelf heeft bovendien ook baat bij deelname aan klinische studies omdat deze een bijkomende kans op genezing kunnen bieden.
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Gachev, Emil Mariov. "Small glaciers in the Dinaric Mountains after eight years of observation: On the verge of extinction?" Acta geographica Slovenica 60, no. 2 (2020): 191–211. http://dx.doi.org/10.3986/ags.8092.

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This study presents results from regular observation of permanent and summer-persisting firn-ice bodies in the highest parts of the Dinaric Alps. The sizes of six small glaciers and two snow patches on the Prokletije Massif (in Albania) and the Durmitor Massif (in Montenegro) were measured from 2011 to 2018. In recent years, specific cycles of interannual behavior have been observed: a year of considerable snow accumulation (a »recharge« phase), followed by two to four years of gradual decrease (a »wastage« phase). At present, the small glaciers studied exist in unbalanced conditions, which in the long term may lead to their degradation. Progressive warming makes short-term cycle minimums increasingly severe. Their retreat after the summer of 2017 was probably the most pronounced since the Little Ice Age, and small glaciers are on the verge of extinction.
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Reder, Kimo. "The Word Made Flesh Writ Edible: Emily Dickinson’s Micro-Eucharist of Crumb and Berry." Christianity & Literature 66, no. 3 (2017): 520–33. http://dx.doi.org/10.1177/0148333117708259.

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Emily Dickinson, as the enigmatic anti-Madonna of American verse, presides over a Eucharistic micro-drama by suggesting that Words-as-spoken are a sacramental Food. Her repeated tokens of Crumb and Berry are the ritual components of Bread and Wine compressed into nubs, exiles from a collective Loaf and Vine. Dickinson never “took” the public rite of Communion, but performs her own private counter-version via her poems, where “famishing” is used as a progressive verb and “Starvation” is treated as an honorific state. Dickinson’s speaker nibbles at a non-communal crouton in several poems, favoring the nub of a crumb to the risen, levitated Loaf.
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NAVARRO, Guillermo Rafael Beltran, Antenor ZANARDO, Cibele Carolina MONTIBELLER, Thaís Güitzlaf LEME, and Fabiano Tomazini da CONCEIÇÃO. "TERMOBAROMETRIA E TRAJETÓRIA P-T DE METASSEDIMENTOS DO GRUPO ARAXÁ EM GOIÁS." Geosciences = Geociências 38, no. 2 (2019): 315–30. http://dx.doi.org/10.5016/geociencias.v38i2.13589.

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Na região sudeste do estado de Goiás (região de Caldas Novas – Marcelândia - Morrinhos – Rochedo) afloram metassedimentos pelíticos, psamo-pelíticos e psamíticos atribuídos ao Grupo Araxá. Na região de Caldas Novas (Domínio Caldas Novas) as associações minerais relacionadas ao pico metamórfico são típicas da fácies xisto verde superior e o auge metamórfico calculado indica temperaturas entre 500ºC a 570ºC e pressões entre 7–8 kbar em condições de fácies xisto verde superior/anfibolito inferior, no campo de estabilidade da cianita. As associações minerais relacionadas ao pico metamórfico na região entre Marcelândia- Morrinhos – Rochedo (Domínio Araxá Oeste) são típicas da fácies anfibolito médio a superior e os cálculos termobarométricos mostram pico metamórfico a 600ºC-670ºC e 9-11 kbar, em condições de fácies anfibolito, zona da cianita. Os cálculos com o geotermômetro Zr-in-Rt, realizados para pressões de 10 kbar, apontam temperatura mínima de 611ºC e máxima de 692ºC. A trajetória P-T inferida, com base nos dados texturais e termobarométricos, é horária. As associações minerais observadas e os dados termobarométricos sugerem um zoneamento metamórfico progressivo de E para W no Grupo Araxá na região, e sugerem que os conjuntos possuem histórias metamórficas diferentes e que o zoneamento metamórfico é resultado da estruturação tectônica.
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Falcão de Campos, Catarina, Miguel Oliveira Santos, Rafael Roque, Isabel Conceição, and Mamede de Carvalho. "Mitochondrial Neurogastrointestinal Encephalomyopathy: Novel Pathogenic Mutation in Thymidine Phosphorylase Gene in a Patient from Cape Verde Islands." Case Reports in Neurological Medicine 2019 (December 11, 2019): 1–4. http://dx.doi.org/10.1155/2019/5976410.

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Mitochondrial Neurogastrointestinal Encephalomyopathy (MNGIE) is a rare autosomal recessive disorder caused by mutations in the gene encoding the Thymidine Phosphorylase (TP). It is clinically characterized by severe gastrointestinal dysmotility, cachexia, palpebral ptosis, ophthalmoparesis, sensorimotor polyneuropathy and leukoencephalopathy. The diagnosis is established by the presence of typical clinical and neuroimaging features, positive family history, and abnormal genetic test. A 19-year-old Cape Verdean patient with a history since childhood of recurrent episodes of nausea, vomiting, diarrhoea and painful abdominal distension associated with progressive motor disability with difficulty in climbing stairs and running and clumsiness with her hands. The diagnostic workup was suggestive of MNGIE. Genetic screening of the TYMP gene identified a novel mutation (c. 1283 G>A). Patients with MNGIE have significant comorbidity and mortality, and they are frequently misdiagnosed. A better acknowledgment of this disorder is essential to permit an earlier diagnosis and to improve disease management.
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Silva, Marília De Moraes, Larissa Ramos Botossi, Augusto Gardezani Baesso, et al. "A Inserção da Bananicultura em São Bento do Sapucaí: Práticas Saudáveis e Saberes Gastronômicos na Serra da Mantiqueira." Ágora 18, no. 1 (2016): 108. http://dx.doi.org/10.17058/agora.v18i1.7394.

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Conforme se desenvolvem os estudos e tecnologias e cresce o número de pessoas com alcance a informações, proporcionalmente se eleva a preocupação com a saúde e o bem-estar físico e mental por meio de uma alimentação mais saudável. Paralelamente a isso, é indispensável praticar uma utilização mais consciente da comida produzida, o que acaba por refletir em progressos econômicos, além da melhor distribuição de alimento à população. Em meio a essa problemática, a filosofia do slow food faz-se ainda mais importante: a valorização do pequeno produtor gera benefícios a todo o ciclo envolvido. A partir desses fatores, enxerga-se um grande potencial na banana, fruta mundialmente apreciada e largamente produzida, tomando como foco, no presente caso, a grande produção existente na cidade de São Bento do Sapucaí, SP. Com o intuito de unir o ideal de alimentação saudável e um melhor aproveitamento da extensa produção, surge a intenção de se utilizar a fruta ainda verde, na forma de biomassa e farinha, aproveitando sua característica prebiótica conferida pelo amido resistente, carboidrato capaz de promover um incremento nutricional no alimento, além de reduzir as chances de doenças. Dessa forma, o objetivo deste trabalho é estudar a possibilidade de elaboração de preparos culinários com aplicação dos produtos da banana verde e realizar análise sensorial, a fim de testar sua aceitabilidade com a população e tornar seu uso e seus benefícios mais conhecidos.
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Maio, Paula, Diogo Bento, Raquel Vieira, Ana Afonso, Fernanda Sachse, and Heinz Kutzner. "Non Hodgkin T cell lymphoma: an atypical clinical presentation." Anais Brasileiros de Dermatologia 88, no. 2 (2013): 264–67. http://dx.doi.org/10.1590/s0365-05962013000200016.

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Cytotoxic lymphomas comprise a spectrum of peripheral T-cell lymphomas that can have a initial or late cutaneous presentation. We describe a 46-year-old man from Cape Verde, with a dermatosis involving his face and trunk, consisting of monomorphic papules with a smooth surface and both motor and sensory polyneuropathy.The hypothesis of leprosy was supported by the clinical and initial hystopathological findings and the patient was referred to our hospital with suspected Hansen's disease. In the new skin and lymph node biopsies a lymphocyte population was identified whose immunohystochemistry study allowed the diagnosis of T-cell lymphoma with expression of cytotoxic markers. The patient was started on chemotherapy with initial remission of the skin lesions but, subsequently, progression of systemic disease.
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Wang, J., J. Li, S. Qin, et al. "Randomized multicenter phase III trial of oxaliplatin plus raltitrexed compared to oxaliplatin plus fluorouracil and leucovorin treatment in recurrent and metastatic colorectal cancer." Journal of Clinical Oncology 25, no. 18_suppl (2007): 4102. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.4102.

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4102 Purpose: To compare oxaliplatin (L-OHP) plus raltitrexed (RTX) with L-OHP plus fluorouracil and leucovorin (LV/5FU) for patients (pts) with recurrent and metastatic colorectal cancer(CRC). Methods: Eligible pts had to have histologically proven recurrent or metastatic CRC,not having previously received oxaliplatin as palliative chemotherapy,ECOG PS = 2,age:18∼70,and adequate hematological,renal and hepatic function.After written informed consent,pts were randomized to L-OHP:130 mg/m2 d1 + RTX: 3 mg/m2 d1 (Arm A) or + LV: 200 mg/m2 + 5FU:375 mg/m2 d1–5 (Arm B). Results: Between Jan 2005 and July 2006, 216 pts were enrolled at 15 centers in China.112 pts (mean age: 55.0 (19∼70), M/F: 57/46, PS 0/1/2: 46/53/13) were randomly assigned to A and 102 (mean age: 54.2(22∼70), M/F: 54/46, PS 0/1/2: 44/59/9) to B. 203 pts were eligible for response evaluation (A:103, B:100).The median number of cycles was 4 (1∼6) in A and 3 (1∼6) in B (P=0.1431).The RR was 29.1% (CR:2, PR:28, SD:50 , PD:23) in A and 17.0% (CR:2, PR:15, SD:46 , PD:37) in B (P=0.0437).The disease-control rate was 77.7% in A and 63.0% in B (P=0.0237). After a median follow-up of 10 months (4–16.5),92 pts had had progression of disease (40 in A and 52 in B); 73 deaths had occurred (35 in A and 38 in B), median time to progression was not reached. Following-up is ongoing.The median QoL scores for the two arms were comparable. 214 were included in the safety analyses (A:112, B:102). There was a higher incidence of neutropenia (48.2% verse 29.4%, P=0.005) and transaminase increase (49.1% verse 35.3%, P=0.041) among A. Grade 3 or 4 neutropenia was much common in pts in A than those in B (20.5% verse 4.9% , P=0.001), but was complicated by fever in only 3.6% of cases (4 pts) in A and in 2.9% of cases (3 pts) in B. No pts were dead or infectious due to neutropenia. There were similar rates of grade 3 or 4 transaminase elevation in the two groups. Vomitting and anorexia were much commoner with B. Conclusions: The L-OHP+RTX seems beneficial in recurrent and metastatic CRC, demonstrating better response rate and higher disease control rate with acceptable tolerability, maintenance of QoL and convenient administration schedule. No significant financial relationships to disclose.
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Yalçın, İlimdar, Fikret Soyer, Fikret Ramazanoğlu, and Atakan Aksu. "Investigation of variations in terms of decision making and trait anxiety level of football refereesFutbol hakemlerinin karar verme ve sürekli kaygı düzeylerinin bazı değişkenler açısından incelenmesi." Journal of Human Sciences 13, no. 3 (2016): 5681. http://dx.doi.org/10.14687/jhs.v13i3.4280.

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This study has been done in the purpose of investigation the decision making and trait anxiety level of football referees under some variations.Study has been applied to 72 football referees out of 89 (%80.8), regional and national referees, whom work from East and South Easter Anatolian region in 8th and 13th sections.In the study, Mann et al. (1998), “Melbourne Decision Making Scale” adapted by Deniz (2004) and Turkish “Trait Anxiety Inventory” adapted by Türker, Öner and Le Compte (1983) developed by Spielberger and friends. SPSS 22 package program was used to analyze the data obtained in the study and the level of significance was taken as p <0.05. T-test and One-Way Anova were used in the study.As the result of the analysis, in decision making process, the education of self-respect and high attention favors the referees. Those whom has worked more, thus have more experience, tend to have a higher level of decision making. It has been determined that as the age progresses at the level of trait anxiety, there is a regular decrease in trait anxiety level. It has been determined that the level of trait anxiety of the referees who have graduate education level is lower than that of the referees who have undergraduate and graduate degrees. ÖzetBu çalışma, bölgesel ve ulusal futbol hakemlerin karar verme ve sürekli kaygı düzeylerinin bazı değişkenler açısından incelemesi amacıyla yapılmıştır.Araştırma, Doğu ve Güneydoğu Anadolu Bölgesi'nde 8. ve 13. Bölge’de bulunan bölgesel ve ulusal futbol hakemi olan toplam 89 hakemden 72 (% 80,8) hakeme uygulanmıştır.Çalışmada, Mann ve Ark. (1998) tarafından geliştirilmiş olup, Deniz (2004) tarafından Türkçeye uyarlanan ''Melbourne Karar Verme Ölçeği'' ve Spielberger ve arkadaşları (1970) tarafından geliştirilen Öner ve Le Compte (1983) tarafından Türkçeye uyarlanan ''Sürekli Kaygı Envanteri'' kullanılmıştır. Araştırmada elde edilen verileri analiz etmek için SPSS 22 paket programı kullanılmış olup anlamlılık düzeyi p<0.05 olarak alınmıştır. Çalışmada t testi ve One -Way Anova kullanılmıştır.Çalışma sonucunda, Karar vermede özsaygı ve dikkatli karar verme düzeylerinde eğitim düzeyi üst seviyede olmasının hakemler lehine önemli bir faktör olduğu tespit edilmiştir. Hakemlik yılı fazla olan futbol hakemlerinin dikkatli karar verme düzeyinin yüksek olduğu gözlenmiştir. Sürekli kaygı düzeyinde yaş ilerledikçe sürekli kaygı düzeyinde de düzenli bir düşüşün olduğu tespit edilmiştir. Eğitimi düzeyi yüksek lisans olan hakemlerin sürekli kaygı düzeyi eğitim durumu ön lisans ve lisans olan hakemlere göre daha düşük olduğu tespit edilmiştir.
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Faria, B., and J. F. B. D. Fonseca. "Investigating volcanic hazard in Cape Verde Islands through geophysical monitoring: network description and first results." Natural Hazards and Earth System Sciences 14, no. 2 (2014): 485–99. http://dx.doi.org/10.5194/nhess-14-485-2014.

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Abstract. We describe a new geophysical network deployed in the Cape Verde Archipelago for the assessment and monitoring of volcanic hazards as well as the first results from the network. Across the archipelago, the ages of volcanic activity range from ca. 20 Ma to present. In general, older islands are in the east and younger ones are in the west, but there is no clear age progression of eruptive activity as widely separated islands have erupted contemporaneously on geological timescales. The overall magmatic rate is low, and there are indications that eruptive activity is episodic, with intervals between episodes of intense activity ranging from 1 to 4 Ma. Although only Fogo Island has experienced eruptions (mainly effusive) in the historic period (last 550 yr), Brava and Santo Antão have experienced numerous geologically recent eruptions, including violent explosive eruptions, and show felt seismic activity and geothermal activity. Evidence for recent volcanism in the other islands is more limited and the emphasis has therefore been on monitoring of the three critical islands of Fogo, Brava and Santo Antão, where volcanic hazard levels are highest. Geophysical monitoring of all three islands is now in operation. The first results show that on Fogo, the seismic activity is dominated by hydrothermal events and volcano-tectonic events that may be related to settling of the edifice after the 1995 eruption; in Brava by volcano-tectonic events (mostly offshore), and in Santo Antão by volcano-tectonic events, medium-frequency events and harmonic tremor. Both in Brava and in Santo Antão, the recorded seismicity indicates that relatively shallow magmatic systems are present and causing deformation of the edifices that may include episodes of dike intrusion.
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40

Faria, B., and J. F. B. D. Fonseca. "Investigating volcanic hazard in Cape Verde Islands through geophysical monitoring: network description and first results." Natural Hazards and Earth System Sciences Discussions 1, no. 5 (2013): 4997–5032. http://dx.doi.org/10.5194/nhessd-1-4997-2013.

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Abstract. We describe a new geophysical network deployed in the Cape Verde archipelago for the assessment and monitoring of volcanic hazards, and the first results from the network. Across the archipelago, the ages of volcanic activity range from ca. 20 Ma to present. In general, older islands are in the east and younger ones are in the west, but there is no clear age progression and widely-separated islands have erupted contemporaneously on geological time scales. The overall magmatic rate is low, and there are indications that eruptive activity is episodic, with intervals between episodes of intense activity ranging from 1 to 4 Ma. Although only Fogo island has experienced eruptions (mainly effusive) in the historic period (last 550 yr), Brava and Santo Antão have experienced numerous geologically recent eruptions including violent explosive eruptions, and show felt seismic activity and geothermal activity. Evidence for recent volcanism in the other islands is more limited and the emphasis has therefore been on monitoring of the three critical islands of Fogo, Brava and Santo Antão, where volcanic hazard levels are highest. Geophysical monitoring of all three islands is now in operation. The first results show that in Fogo the seismic activity is dominated by hydrothermal events and volcano-tectonic events that may be related to settling of the edifice after the 1995 eruption; in Brava by volcano-tectonic events (mostly offshore), and in Santo Antão by volcano-tectonic events, medium frequency events and harmonic tremor. Both in Brava and in Santo Antão, the recorded seismicity indicates that relatively shallow magmatic systems are present and causing deformation of the edifices that may include episodes of dike intrusion.
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Brambilla, Massimo, Lorenzo Luigi Columbo, Maurizio Dabbicco, Francesco De Lucia, Francesco Paolo Mezzapesa, and Gaetano Scamarcio. "Versatile Multimodality Imaging System Based on Detectorless and Scanless Optical Feedback Interferometry—A Retrospective Overview for A Prospective Vision." Sensors 20, no. 20 (2020): 5930. http://dx.doi.org/10.3390/s20205930.

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In this retrospective compendium, we attempt to draw a “fil rouge” along fifteen years of our research in the field of optical feedback interferometry aimed at guiding the readers to the verge of new developments in the field. The general reader will be moved at appreciating the versatility and the still largely uncovered potential of the optical feedback interferometry, for both sensing and imaging applications. By discovering the broad range of available wavelengths (0.4–120 μm), the different types of suitable semiconductor lasers (Fabry–Perot, distributed feedback, vertical-cavity, quantum-cascade), and a number of unconventional tenders in multi-axis displacement, ablation front progression, self-referenced measurements, multispectral, structured light feedback imaging and compressive sensing, the specialist also could find inspirational suggestions to expand his field of research.
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42

Sennett, James F. "Bare bones inclusivism and the implications of Romans 1:20." Evangelical Quarterly 77, no. 4 (2005): 309–19. http://dx.doi.org/10.1163/27725472-07704002.

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This paper is a defense of Christian inclusivism – the view that there is salvation in Christ available to those who never explicitly embrace Christianity. This defense progresses in two steps. First I identify what I call ‘Bare Bones Inclusivism,’ a sort of ‘stripped down’ model of the doctrine that commits only to the essential claim of the view, without commitment – explicit or implicit – to any of the positions that are so often understood as codicils or corollaries of inclusivism. Second I offer an argument for Bare Bones Inclusivism that is motivated by a passage most often associated with Christian exclusivism – Romans 1:20. I use this verse to defend the key premise of my argument – that the condemnation of the unevangelized is justified only if they have not responded appropriately to general revelation. I close with responses to a couple of key objections that have been raised against my argument.
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Rangel, Asunción. "La enfermedad y la escritura." Acta Hispanica 22 (January 1, 2017): 73–84. http://dx.doi.org/10.14232/actahisp.2017.22.73-84.

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The topic of the illness reveals at various points in Peruvian-Japanese poetry José Watanabe. Born in 1945 in Laredo, Peru, he died at the age of 62, suffering from throat cancer. It is not strange to find allusions to the degenerative process of the body – derived from the disease – and to the cure in, for example, “Krankenhaus” (hospital, in German), a section of the book El huso de la palabra (1989). In his poetry about disease, Watanabe involves, on the one hand, knowledge derived from medicine and, in addition, knowledge that is outside the frame of writing: advice, family or community stories, what lives and arises –to put it with one of his verses– “en la honda boca de los mayors”. The notion of disease that is poetically devised, links medical knowledge and those that come from the family. The idea of the disease must be incorporated into the way of living it. The sick body to which Watanabe refers is one who feels, perceives and experiences the ailment as a way of living, but also as a way of dying: the agony. His poetry is a way of living dying and dying in living, within the framework of disease that is nothing other than agony. This comparison is significant if we take into account that the process of writing and reading are seen as the life of poetry (in its writing, in its reading) that goes, as it progresses verse by verse, irremediably to death. At the end of reading the poem, it dies; while reading, agonizes. This allows you to venture a path of reading that splices writing, body, disease, life and death.
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Verchère, Alban. "Le développement durable en question : analyses économiques autour d’un improbable compromis entre acceptions optimiste et pessimiste du rapport de l’Homme à la Nature." L'Actualité économique 87, no. 3 (2012): 337–403. http://dx.doi.org/10.7202/1009279ar.

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Le concept de développement durable s’est considérablement popularisé depuis la parution du rapport Brundtland il y a presque 25 ans. S’il faut sans doute l’opérationnaliser pour le faire entrer dans le quotidien des agents, il reste au fond un concept mou aux origines aussi lointaines que protéiformes. L’objet de cet article est de faire état de la longue série de débats sur le rapport de l’homme à la nature en économie : de Malthus aux conceptions faibles et fortes du développement durable. On verra que si ces débats illustrent l’opposition maintes fois renouvelée entre partis de l’optimisme et du pessimisme, tous ont surtout régulièrement fait valoir des arguments sensés ou intelligibles, au point de contribuer ensemble à faire progresser l’analyse économique du développement durable autour de ce que l’on peut désormais concevoir comme deux traditions s’enrichissant in fine l’une de l’autre : l’économie de l’environnement et des ressources naturelles d’un côté, et la plus récente écologie économique de l’autre.
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LAGAE, VERONIQUE. "Evolution et diversification des emplois de la locution en fait de." Journal of French Language Studies 17, no. 3 (2007): 277–95. http://dx.doi.org/10.1017/s0959269507003006.

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Dans cette étude diachronique, il est démontré que les trois types d'emplois de la locution en fait de qui coexistent dans la langue actuelle, représentent différentes étapes dans l'évolution de la locution, déjà attestée en moyen français avec des emplois du premier type. Une étude de corpus permet de situer l'apparition des deux autres types respectivement au milieu du XIXe siècle et dans la deuxième moitié du XXe siècle Il apparaît en outre que la diversification des valeurs sémantiques de en fait de va de pair avec deux tendances opposées dans sa distribution: d'une part, une extension de son usage à d'autres catégories grammaticales que celle du nom et, d'autre part, une restriction progressive quant aux positions et fonctions syntaxiques qu'il peut occuper. Ces données confirment l'idée que l'innovation linguistique peut favoriser le passage d'une fonction syntaxique (complément plus ou moins lié au verbe) à une fonction discursive (constituant périphérique marqueur de thématisation, de cadrage etc.)
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Lieber, Keir A., and Daryl G. Press. "The End of MAD? The Nuclear Dimension of U.S. Primacy." International Security 30, no. 4 (2006): 7–44. http://dx.doi.org/10.1162/isec.2006.30.4.7.

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For nearly half a century, the world's most powerful nuclear-armed states have been locked in a condition of mutual assured destruction. Since the end of the Cold War, however, the nuclear balance has shifted dramatically. The U.S. nuclear arsenal has steadily improved; the Russian force has sharply eroded; and Chinese nuclear modernization has progressed at a glacial pace. As a result, the United States now stands on the verge of attaining nuclear primacy, meaning that it could conceivably disarm the long-range nuclear arsenals of Russia and China with a nuclear first strike. A simple nuclear exchange model demonstrates that the United States has a potent first-strike capability. The trajectory of nuclear developments suggests that the nuclear balance will continue to shift in favor of the United States in coming years. The rise of U.S. nuclear primacy has significant implications for relations among the world's great powers, for U.S. foreign policy, and for international relations scholarship.
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Buryachkovskaya, L. I., N. V. Lomakin, E. A. Shirokov, N. K. Vitko, and D. N. Verbovoy. "A Case of Successful Thrombolysis on the Verge of a Reperfusion Revolution in Coronary Cardiology and Vascular Neurology." Kardiologiia 59, no. 6 (2019): 91–96. http://dx.doi.org/10.18087/cardio.2019.6.n686.

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Thrombolytic therapy (TLT), as a method of treatment, began to develop in the second half of the 50s of the last century. At that time, there was an accumulation of data on its effectiveness, side effects and contraindications, as well as the development of fibrinolytic drugs, such as fibrinolysin, streptokinase, urokinase, and the conditions for their administration. Official recognition of TLT in regulatory documents began only in the 80s after the development of more effective and safe tissue plasminogen activators. However, on the threshold of an era of development in this area in the treatment of patients with thrombosis of the coronary, carotid, and other peripheral vascular regions, the researchers obtained conflicting data on the results of the use of thrombolytics. There was no concept of a therapeutic window for the use of TLT, there was no data on possible combinations of thrombolytic drugs with anticoagulants, the high probability of bleeding prevented widespread introduction of the method into clinical practice. At that time, vascular imaging and laboratory diagnostics were not sufficiently developed, there was no consensus of the world’s leading experts on the benefits of thrombolysis. The use of TLT in acute arterial thrombosis required not only clinical experience, but also courage and ability to make non-standard decisions. The authors of the article analyze in detail the case of rescuing a patient with progressive thrombotic occlusion of the arteries of the brain stem. Then the pioneer in the field of thrombolytic therapy E. I. Chazov and his colleagues took responsibility for the application in this situation of an insufficiently studied treatment method with uncertain consequences. This decision was not due to the identity of the patient or the threat of an internal investigation. Marshal or soldier – it did not matter for E. I. Chazov and his colleagues. If doctors in this clinical situation relied on recommendations, orders and standards, then such a patient would have to wait thrombolysis for another 30 years.
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BREBAN, TINE, and KRISTIN DAVIDSE. "The history of very: the directionality of functional shift and (inter)subjectification." English Language and Linguistics 20, no. 2 (2016): 221–49. http://dx.doi.org/10.1017/s1360674315000428.

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On the basis of extensive corpus analysis, we reconstruct the history of very and the paths of change along which it acquired new meanings. We propose an analytical model that, firstly, assigns general semantic functions to the (sub)modifier relations in the English noun phrase and, secondly, identifies subsenses of these functions on the basis of collocational, semantic and pragmatic distinctions observed in different contexts. Thus, we arrive at a comprehensive description of the various (sub)modifier relations in which very has functioned in its history. Having been borrowed into English as part of fixed collocations such as very Ihus (‘the true Jesus’) and croice verra (‘the true cross’), very successively acquired the functions of descriptive modifier, noun-intensifier, focus marker, adjective-intensifier, classifier, postdeterminer-intensifier, quantifier-intensifier and postdeterminer. This description allows us to interpret the history of very as a paradigm case of progressive grammaticalization and (inter)subjectification involving leftward movement in the English NP (Adamson 2000). Our analytical model allows us to capture finer mechanisms of change such as collocational extension, pragmatically driven host class expansion, invited inferences and analogy.
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49

Farikhin, Zahria Farlydia. "THE STUDY OF INTERTEXTUALITY ON NOVEL ENTITLED A VERY YUPPY WEDDING AND DIVORTIARE BY IKA NATASSA." Lakon : Jurnal Kajian Sastra dan Budaya 8, no. 2 (2019): 70. http://dx.doi.org/10.20473/lakon.v8i2.19775.

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This research aimed to describe intertextual in the novel A Very Yuppy Wedding and Divortiare by Ika Natassa. This research used a descriptive qualitative approach in the form of structural. The result of the data analysis is that theme has similarity. The themes of these novels are love, friendship, and family. Figure and characterization in the novels has less different, the figures describe as a work hard figure not only for the job but also on their relationship. In both of the novel, both of the main characters are women and use the first person as the point of view. Whereas the plot of the novels has different, that is novel Divortiare has a flash-back plot and A Verry Yuppy Wedding has a progressive plot. Both of the novel have differences in the story but have the same happy ending. The background of the stories are not different. Ika Natassa takes both of the settings in Jakarta. The conclusion is both of the novels have no significant differences.
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50

Gendreau-Massaloux, Michèle. "Réflexion d’une hispaniste." Études littéraires 32, no. 1-2 (2005): 201–10. http://dx.doi.org/10.7202/501266ar.

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Après la période andalouse qui marqua une cohabitation linguistique et religieuse où interagirent savoirs d'Orient et d'Occident, du Nord et du Sud, l'histoire espagnole semble ordonner en même temps que l'unification castillane, une progressive pente à l'intolérance avec l'institution de l'Inquisition et les proclamations nombreuses des Statuts de la propreté du sang, dès le XVIe siècle. Le Siècle d'Or est le pic des politiques de l'exclusion civile et religieuse en même temps qu'il interroge le lien causal entre répression et épanouissement remarquable des arts qui notamment organisent un contrepoint à la vérité officielle et intolérante en faisant de leurs emprunts mythologiques plus que des motifs d'ornementation. Le XVIIIe siècle verra, en Espagne, l'émergence d'un catholicisme éclairé qui, s'il prend forme parmi les clercs, est soutenu par des figures importantes des lettres, comme le bénédictin Feijóo qui combattra autant les préjugés universitaires que religieux. Ce combat confirmera combien la tolérance ne peut se penser dans un premier temps que dans le christianisme ou, autrement dit, que l'origine de la tolérance postule le retour aux origines du christianisme.
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