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Relevant bibliographies by topics / Very early onset IBD

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Journal articles

Academic literature on the topic 'Very early onset IBD'

Author: Grafiati

Published: 1 April 2023

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Journal articles on the topic "Very early onset IBD"

1

Batura, Vritika, and Aleixo M. Muise. "Very early onset IBD." Current Opinion in Allergy and Clinical Immunology 18, no. 6 (2018): 470–80. http://dx.doi.org/10.1097/aci.0000000000000486.

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2

Magg, Thomas, Anna Shcherbina, Duran Arslan, et al. "CARMIL2 Deficiency Presenting as Very Early Onset Inflammatory Bowel Disease." Inflammatory Bowel Diseases 25, no. 11 (2019): 1788–95. http://dx.doi.org/10.1093/ibd/izz103.

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Abstract Background Children with very early onset inflammatory bowel diseases (VEO-IBD) often have a refractory and severe disease course. A significant number of described VEO-IBD-causing monogenic disorders can be attributed to defects in immune-related genes. The diagnosis of the underlying primary immunodeficiency (PID) often has critical implications for the treatment of patients with IBD-like phenotypes. Methods To identify the molecular etiology in 5 patients from 3 unrelated kindred with IBD-like symptoms, we conducted whole exome sequencing. Immune workup confirmed an underlying PID.

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3

Conrad, Maire A., and Judith R. Kelsen. "Genomic and Immunologic Drivers of Very Early-Onset Inflammatory Bowel Disease." Pediatric and Developmental Pathology 22, no. 3 (2019): 183–93. http://dx.doi.org/10.1177/1093526619834807.

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Purpose of Review Inflammatory bowel disease (IBD) is a multifactorial disease caused by dysregulated immune responses to commensal or pathogenic intestinal microbes, resulting in chronic intestinal inflammation. However, a subset of patients with IBD diagnosed <6 years of age, known as very early-onset (VEO)-IBD, can be phenotypically and genetically distinct from older onset IBD. We aim to review the clinical presentation of children with VEO-IBD and recent discoveries that point to the underlying genomic and immunologic drivers of disease, and the significant impact on our therapeutic de

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4

Levine, Anne E., Dominique Mark, Laila Smith, Hengqi B. Zheng, and David L. Suskind. "Pharmacologic Management of Monogenic and Very Early Onset Inflammatory Bowel Diseases." Pharmaceutics 15, no. 3 (2023): 969. http://dx.doi.org/10.3390/pharmaceutics15030969.

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Inflammatory bowel disease (IBD) is treated with a variety of immunomodulating and immunosuppressive therapies; however, for the majority of cases, these therapies are not targeted for specific disease phenotypes. Monogenic IBD with causative genetic defect is the exception and represents a disease cohort where precision therapeutics can be applied. With the advent of rapid genetic sequencing platforms, these monogenic immunodeficiencies that cause inflammatory bowel disease are increasingly being identified. This subpopulation of IBD called very early onset inflammatory bowel disease (VEO-IBD

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5

Liang, Guanxiang, Maire A. Conrad, Judith R. Kelsen, et al. "Dynamics of the Stool Virome in Very Early-Onset Inflammatory Bowel Disease." Journal of Crohn's and Colitis 14, no. 11 (2020): 1600–1610. http://dx.doi.org/10.1093/ecco-jcc/jjaa094.

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Abstract Background and Aims Dysbiosis of the gut microbiota is a well-known correlate of the pathogenesis of inflammatory bowel disease [IBD]. However, few studies have examined the microbiome in very early-onset [VEO] IBD, which is defined as onset of IBD before 6 years of age. Here we focus on the viral portion of the microbiome—the virome—to assess possible viral associations with disease processes, reasoning that any viruses potentially associated with IBD might grow more robustly in younger subjects, and so be more detectable. Methods Virus-like particles [VLPs] were purified from stool

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6

Ahamed, Nazmul, Mukesh Khadga, Wahiduzzaman Majumder, and Md Rukunuzzaman. "An Eleven Months Old Infant with Very Early Onset Inflammatory Bowel Diseases (IBD): A Rare Case Report." Bangladesh Medical Journal 50, no. 2 (2022): 45–49. http://dx.doi.org/10.3329/bmj.v50i2.61220.

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Inflammatory bowel disease (IBD) in pediatric cases has been seen rapidly increasing in number over the last decade. Now a days four types of pediatric IBD has been identified: less than ten years of age - early onset IBD, less than six years of age - very early onset IBD, less than two years of age- infantile IBD and less than twenty eight days of age - neonatal onset IBD. Young children presented with more aggressive clinical features and severity is more than the older children and adults. Early onset disease presenting in children may have a monogenic basis. Infantile IBD or neonatal IBD h

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7

Holbein, Christina E., Jill Plevinsky, Trusha Patel, Maire C. Conrad, and Judith R. Kelsen. "Pediatric Global Health in Children with Very Early-Onset Inflammatory Bowel Disease." Journal of Pediatric Psychology 46, no. 7 (2021): 747–56. http://dx.doi.org/10.1093/jpepsy/jsab035.

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Abstract Objective Children with very early-onset inflammatory bowel disease (VEO-IBD) represent a distinct group of patients with IBD with unique phenotypic and genetic characteristics; however, they are frequently omitted from psychosocial research. This study used a novel, brief measure of pediatric global health to assess (1) overall health-related quality of life (HRQOL) in children with VEO-IBD, (2) HRQOL compared to healthy children, and (3) whether gastrointestinal symptoms account for the differences in HRQOL between these groups. Methods Caregivers of 51 children with VEO-IBD (Mage =

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8

Alahmari, A. A., A. M. Al-Bahlani, B. Frenette, A. Xuan-Lan Nguyen, N. Ahmed, and A. Sant’Anna. "A251 VERY EARLY ONSET INFLAMMATORY BOWEL DISEASE IN CHILDREN: A SINGLE CENTER EXPERIENCE OVER 15 YEARS." Journal of the Canadian Association of Gastroenterology 3, Supplement_1 (2020): 128–29. http://dx.doi.org/10.1093/jcag/gwz047.250.

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Abstract Background Very-early-onset inflammatory bowel disease (VEOIBD) refers to an IBD diagnosis established before the 6th year of life, including a subset of patients with disease onset before the age of 2 years, known as infantile-onset IBD (IO-IBD) (1). VEO-IBD accounts for 15% of pediatric IBD and infantile IBD in approximately 1% (2,3). VEOIBD is considered to be a unique entity, and compared to adults with IBD, VEO-IBD children are more likely to present with extensive and treatment-resistant disease (4). Aims To analyze the clinical characteristics and management of patients diagnos

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9

Örtqvist, Anne K., Cecilia Lundholm, Jonas Halfvarson, Jonas F. Ludvigsson, and Catarina Almqvist. "Fetal and early life antibiotics exposure and very early onset inflammatory bowel disease: a population-based study." Gut 68, no. 2 (2018): 218–25. http://dx.doi.org/10.1136/gutjnl-2017-314352.

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ObjectiveEarlier studies on antibiotics exposure and development of IBD (Crohn’s disease (CD) and ulcerative colitis (UC)) may have been biased by familial factors and gastroenteritis. We aimed to estimate the association between antibiotics during pregnancy or infantile age and very early onset (VEO) IBD.DesignIn this cohort study of 827 239 children born in Sweden between 2006 and 2013, we examined the link between exposure to systemic antibiotics and VEO-IBD (diagnosis <6 years of age), using Cox proportional hazard regression models. Information on antibiotics and IBD was retrieved from

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10

Pavanello, P. M., P. Moras, G. Cendon, A. Tommasini, and S. Martelossi. "P093 Very early onset IBD: the importance of genetic screening." Digestive and Liver Disease 50, no. 4 (2018): e391. http://dx.doi.org/10.1016/s1590-8658(18)31092-2.

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