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Journal articles on the topic 'Vessel mimic'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Zarka, Farah, Charles Veillette, and Jean-Paul Makhzoum. "A Review of Primary Vasculitis Mimickers Based on the Chapel Hill Consensus Classification." International Journal of Rheumatology 2020 (February 18, 2020): 1–11. http://dx.doi.org/10.1155/2020/8392542.

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Primary systemic vasculitides are rare diseases that may manifest similarly to more commonly encountered conditions. Depending on the size of the vessel affected (large vessel, medium vessel, or small vessel), different vasculitis mimics must be considered. Establishing the right diagnosis of a vasculitis mimic will prevent unnecessary immunosuppressive therapy.

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Maningding, Ernest, and Tanaz A. Kermani. "Mimics of vasculitis." Rheumatology 60, no. 1 (2020): 34–47. http://dx.doi.org/10.1093/rheumatology/keaa495.

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Abstract While prompt diagnosis of vasculitis is important, recognition of vasculitis mimics is equally essential. As in the case of vasculitis, an approach to mimics based on the anatomic size of vessels can be useful. Infections can mimic vasculitis of any vessel size, including the formation of aneurysms and induction of ANCAs. Genetic disorders and vasculopathies are important considerations in large and medium vessel vasculitis. Cholesterol emboli, thrombotic conditions and calciphylaxis typically affect the medium and small vessels and, like vasculitis, can cause cutaneous, renal and CNS

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Srinivasan, Visish M., Stephen R. Chen, Kevin M. Camstra, Gouthami Chintalapani, and Peter Kan. "Development of a recalcitrant, large clot burden, bifurcation occlusion model for mechanical thrombectomy." Neurosurgical Focus 42, no. 4 (2017): E6. http://dx.doi.org/10.3171/2017.1.focus16501.

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OBJECTIVE Stroke is a major cause of disability and death in adults. Several large randomized clinical trials have shown the significant benefit of mechanical thrombectomy with modern stent retrievers in the treatment of large-vessel occlusions. However, large clots located at bifurcations remain challenging to treat. An in vivo model of these recalcitrant clots needs to be developed to test future generations of devices. METHODS Autologous blood was drawn from anesthetized swine via a femoral sheath. Blood was then mixed with thrombin, calcium chloride, and saline, and injected into silicone

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Levesque, Lucie, and D. Mantovani. "The Effect of Dynamical Strain on the Maturation of Collagen-Based Cell-Containing Scaffolds for Vascular Tissue Engineering." Advanced Materials Research 409 (November 2011): 152–57. http://dx.doi.org/10.4028/www.scientific.net/amr.409.152.

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Diseases occurring to blood vessel are preferentially solved by replacing the vessel by an autologous graft. When it is not available, a synthetic graft is used which has low patency rates for small diameter (<6 mm) vessels. Tissue engineering of blood vessel aims to improve the performance of vascular substitutes. Bioreactors are used in vascular tissue engineering to mimic the mechanical and biochemical environment of blood vessel. A 2D bioreactor was custom made in order to impose a dynamical strain to silicone membrane receiving the collagen cell-based construct. Collagen gels with vasc

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Fisher, R. G., M. Sanchez-Torres, C. J. Whigham, and J. W. Thomas. ""Lumps" and "bumps" that mimic acute aortic and brachiocephalic vessel injury." RadioGraphics 17, no. 4 (1997): 825–34. http://dx.doi.org/10.1148/radiographics.17.4.9225385.

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Kataoka, Shinichi, Shin-ei Kudo, Masashi Misawa, et al. "Endocytoscopy with NBI has the potential to correctly diagnose diminutive colorectal polyps that are difficult to diagnose using conventional NBI." Endoscopy International Open 08, no. 03 (2020): E360—E367. http://dx.doi.org/10.1055/a-1068-9228.

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Abstract Background and study aims Real-time diagnosis of colorectal polyps is needed to prevent unnecessary resection of benign polyps. The vessels in hyperplastic polyps sometimes mimic the characteristic meshed capillary network of neoplastic lesions on non-magnified narrow-band imaging (NBI). Endocytoscopy in conjunction with NBI (EC-NBI) enables more detailed vessel observation. The current study evaluated whether EC-NBI can accurately diagnose small colorectal lesions with visible vessels on non-magnified NBI. Patients and methods This retrospective study was conducted from January to De

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McCourt, Collette, and Jan P. Dutz. "Making Necrotizing Vasculitis Simple." Journal of Cutaneous Medicine and Surgery 17, no. 4_suppl (2013): S40—S46. http://dx.doi.org/10.2310/7750.2013.wound6.

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Background: Cutaneous necrotizing vasculitides (CNV) represent a heterogeneous group of inflammatory diseases affecting the skin blood vessels, characterized histologically by transmural inflammation of the blood vessel wall with fibrinoid necrosis and clinically characterized by palpable purpura, leading to ulceration. These syndromes represent a spectrum of disease from limited cutaneous small vessel vasculitis to rapidly progressive systemic vasculitis. Moreover, a number of diseases can mimic vasculitis in the skin, thereby presenting diagnostic difficulties for physicians. Objective: We p

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He, X. S., and J. G. Georgiadis. "Pressure Propagation in Pulsatile Flow Through Random Microvascular Networks." Journal of Biomechanical Engineering 115, no. 2 (1993): 180–86. http://dx.doi.org/10.1115/1.2894119.

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A microvascular network with random dimensions of vessels is built on the basis of statistical analysis of conjuctival beds reported in the literature. Our objective is to develop a direct method of evaluating the statistics of the pulsatile hydrodynamic field starting from a priori statistics which mimic the large-scale heterogeneity of the network. The model consists of a symmetric diverging-converging dentritic network of ten levels of vessels, each level described by a truncated Gaussian distribution of vessel diameters and lengths. In each vascular segment, the pressure distribution is gi

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9

Reininger, A. J. "Primary haemostasis and its assessment by laboratory tests." Hämostaseologie 26, no. 01 (2006): 42–47. http://dx.doi.org/10.1055/s-0037-1616875.

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SummaryPlatelets constantly patrol the inner surface of blood vessels searching leaks to be sealed, in order to prevent blood loss. When they detect a vessel injury their action can be divided into three phases. Adhesion: The platelets adhere to the injured blood vessel wall via their receptors glycoprotein (GP) Ib and integrin α2bβ3 (GPIIb/IIIa) mediated by the ligands von Willebrand factor (VWF), fibrinogen and others. Aggregation: Platelets stick to each other through fibrinogen bridging integrin α2bβ3 (GPIIb/IIIa) on adjacent platelets. Secretion: During activation the content of platelet

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Liu, Da Zhi, Glen C. Jickling, Bradley P. Ander, et al. "Elevating microRNA-122 in blood improves outcomes after temporary middle cerebral artery occlusion in rats." Journal of Cerebral Blood Flow & Metabolism 36, no. 8 (2015): 1374–83. http://dx.doi.org/10.1177/0271678x15610786.

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Because our recent studies have demonstrated that miR-122 decreased in whole blood of patients and in whole blood of rats following ischemic stroke, we tested whether elevating blood miR-122 would improve stroke outcomes in rats. Young adult rats were subjected to a temporary middle cerebral artery occlusion (MCAO) or sham operation. A polyethylene glycol-liposome-based transfection system was used to administer a miR-122 mimic after MCAO. Neurological deficits, brain infarction, brain vessel integrity, adhesion molecule expression and expression of miR-122 target and indirect-target genes wer

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Daniel Nyancho, Ryan Cheung, Aardhra Venkatachalam, et al. "Initial Reliability and Validity testing of the DESTINY Stroke and Large Vessel Screening Tool." Journal of Health and Caring Sciences 2, no. 2 (2020): 112–22. http://dx.doi.org/10.37719/jhcs.2020.v2i2.oa004.

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Background: Screening is a valuable tool in emergency medicine for triaging, activation of protocols, and resource allocation. The Dallas Emergency Department Screening Tool to Identify Stroke (DESTINY) was developed to screen for all stroke subtypes, with improved sensitivity for posterior circulation stroke and large vessel occlusion (LVO). The main purpose of this study was to evaluate how reliably the tool could be taught and used by ED Nurses. Methods: This is Phase 1 of a multi-phase study to evaluate the DESTINY tool. A vascular neurologist retrospectively reviewed 409 stroke code

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Zach, Leor, David Goez, Yuval Grober, et al. "MRI-based vessel function maps for high-resolution differentiation between tumor and nontumoral tissues in brain tumor patients." Journal of Clinical Oncology 30, no. 15_suppl (2012): 2078. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.2078.

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2078 Background: Changes in enhancement seen in post treatment brain MRIs in primary and secondary brain malignancies often mimic tumor progression (pseudoprogression, radiation necrosis). Conventional MRI cannot differentiate tumor progression from treatment related effects resulting in suboptimal patient management. Methods: The application of delayed contrast extravasation MRI for depicting unique vessels characteristics with high resolution and high sensitivity to subtle BBB disruption is demonstrated in 17 GBM and 15 brain metastases patients undergoing standard chemoradiation and radiosu

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Tran, Cam Ha T., Edward J. Vigmond, Daniel Goldman, France Plane, and Donald G. Welsh. "Electrical communication in branching arterial networks." American Journal of Physiology-Heart and Circulatory Physiology 303, no. 6 (2012): H680—H692. http://dx.doi.org/10.1152/ajpheart.00261.2012.

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Electrical communication and its role in blood flow regulation are built on an examination of charge movement in single, isolated vessels. How this process behaves in broader arterial networks remains unclear. This study examined the nature of electrical communication in arterial structures where vessel length and branching were varied. Analysis began with the deployment of an existing computational model expanded to form a variable range of vessel structures. Initial simulations revealed that focal endothelial stimulation generated electrical responses that conducted robustly along short unbr

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Kitajima, Hiroaki, Toshinori Iwai, Yasuharu Yajima, and Kenji Mitsudo. "Computational Fluid Dynamics Study of Superselective Intra-arterial Chemotherapy for Oral Cancer: Flow Simulation of Anticancer Agent in the Linguofacial Trunk." Applied Sciences 10, no. 21 (2020): 7496. http://dx.doi.org/10.3390/app10217496.

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Superselective intra-arterial chemotherapy (SSIAC) for oral cancer can deliver a higher concentration of anticancer agent into a tumor-feeding artery than intravenous systemic chemotherapy. However, the agent distribution between the lingual artery and facial artery (FA) is not clear in SSIAC for patients with the linguofacial trunk. The agent distribution in the SSIAC method was investigated using computational fluid dynamics (CFD). Ten three-dimensional vessel models were created from CT images of two patients with oral cancer (patients A and B) with the linguofacial trunk. Catheter models w

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15

Siegler, James E., Jon Rosenberg, Daniel Cristancho, et al. "Computed tomography perfusion in stroke mimics." International Journal of Stroke 15, no. 3 (2019): 299–307. http://dx.doi.org/10.1177/1747493019869702.

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Objective To describe the prevalence and patterns of abnormal findings on automated computed tomography perfusion in patients with stroke mimic. Methods We reviewed a retrospective multi-site cohort of consecutive patients undergoing computed tomography perfusion for suspected acute ischemic stroke within 24 h from last normal (June 2017 to December 2017). The primary outcome was the diagnosis of stroke mimic. Hypoperfusion abnormalities on iSchemaView RAPID automated computed tomography perfusion were compared between patients with stroke/transient ischemic attack and stroke mimic using mixed

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Avasarala, Jagannadha R., Julie R. Jones, and Curtis R. Rogers. "Forkhead box C1 gene variant causing glaucoma and small vessel angiopathy can mimic multiple sclerosis." Multiple Sclerosis and Related Disorders 22 (May 2018): 157–60. http://dx.doi.org/10.1016/j.msard.2018.04.004.

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Yalcin Enis, Ipek, and Telem Gok Sadikoglu. "Design parameters for electrospun biodegradable vascular grafts." Journal of Industrial Textiles 47, no. 8 (2016): 2205–27. http://dx.doi.org/10.1177/1528083716654470.

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The inadequacies of the currently used small diameter, non-biodegradable synthetic grafts prompt researchers to focus on the design parameters of vascular grafts. Since the purpose is to mimic the native vessel as far as possible, the design parameters are mainly determined by the layout of cell types and proteins in the layers of the vessels and the nano and micro structure of their environments. In consequence of this, the complex structure of native vessels has become a broad source of inspiration for researchers. Electrospun fibrous scaffolds with their well accepted advantages are promisi

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Haddock, Rebecca E., T. Hilton Grayson, Therese D. Brackenbury, et al. "Endothelial coordination of cerebral vasomotion via myoendothelial gap junctions containing connexins 37 and 40." American Journal of Physiology-Heart and Circulatory Physiology 291, no. 5 (2006): H2047—H2056. http://dx.doi.org/10.1152/ajpheart.00484.2006.

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Control of cerebral vasculature differs from that of systemic vessels outside the blood-brain barrier. The hypothesis that the endothelium modulates vasomotion via direct myoendothelial coupling was investigated in a small vessel of the cerebral circulation. In the primary branch of the rat basilar artery, membrane potential, diameter, and calcium dynamics associated with vasomotion were examined using selective inhibitors of endothelial function in intact and endothelium-denuded arteries. Vessel anatomy, protein, and mRNA expression were studied using conventional electron microscopy high-res

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Riley, Mark, Ammoura Ibrahim, Maria Kofman, and Ruben Peredo-Wende. "Transthyretin amyloidosis and herpes zoster infection: a mimic of temporal arteritis." BMJ Case Reports 14, no. 6 (2021): e241505. http://dx.doi.org/10.1136/bcr-2020-241505.

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We describe the case of a patient who presented with symptoms of persistent headaches, left-sided facial pain and blurry vision of the left eye. The patient had recovered from a herpes zoster infection of the V1 division of the trigeminal nerve 1 month prior. Serum inflammatory markers were elevated, raising concern for temporal arteritis. Empiric high-dose prednisone was initiated. Bilateral temporal artery biopsies were performed but did not show evidence of vasculitis or multinucleated giant cells. Instead, extracellular material deposits were present within the vessel walls. Congo red stai

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Winderlich, Mark, Linda Keller, Giuseppe Cagna, et al. "VE-PTP controls blood vessel development by balancing Tie-2 activity." Journal of Cell Biology 185, no. 4 (2009): 657–71. http://dx.doi.org/10.1083/jcb.200811159.

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Vascular endothelial protein tyrosine phosphatase (VE-PTP) is an endothelial-specific receptor-type tyrosine phosphatase that associates with Tie-2 and VE-cadherin. VE-PTP gene disruption leads to embryonic lethality, vascular remodeling defects, and enlargement of vascular structures in extraembryonic tissues. We show here that antibodies against the extracellular part of VE-PTP mimic the effects of VE-PTP gene disruption exemplified by vessel enlargement in allantois explants. These effects require the presence of the angiopoietin receptor Tie-2. Analyzing the mechanism we found that anti–VE

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Kim, S. G., A. R. Park, Y. H. Park, et al. "Silk fibroin and poly-caprolactone vascular grafts tested in vitro and in vivo mimic natural vessel." International Journal of Oral and Maxillofacial Surgery 44 (October 2015): e246. http://dx.doi.org/10.1016/j.ijom.2015.08.189.

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22

Liu, Yang, Mehdi Abbasi, Jorge L. Arturo Larco, et al. "Preclinical testing platforms for mechanical thrombectomy in stroke: a review on phantoms, in-vivo animal, and cadaveric models." Journal of NeuroInterventional Surgery 13, no. 9 (2021): 816–22. http://dx.doi.org/10.1136/neurintsurg-2020-017133.

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Preclinical testing platforms have been instrumental in the research and development of thrombectomy devices. However, there is no single model which fully captures the complexity of cerebrovascular anatomy, physiology, and the dynamic artery-clot-device interaction. This article provides a critical review of phantoms, in-vivo animal, and human cadaveric models used for thrombectomy testing and provides insights into the strengths and limitations of each platform. Articles published in the past 10 years that reported thrombectomy testing platforms were identified. Characteristics of each test

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Qian, Ming, Lili Niu, Yanping Wang, et al. "Measurement of flow velocity fields in small vessel-mimic phantoms and vessels of small animals using micro ultrasonic particle image velocimetry (micro-EPIV)." Physics in Medicine and Biology 55, no. 20 (2010): 6069–88. http://dx.doi.org/10.1088/0031-9155/55/20/003.

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Machura, Katharina, Dominik Steppan, Bjoern Neubauer, et al. "Developmental renin expression in mice with a defective renin-angiotensin system." American Journal of Physiology-Renal Physiology 297, no. 5 (2009): F1371—F1380. http://dx.doi.org/10.1152/ajprenal.00378.2009.

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During nephrogenesis, renin expression shifts from the vessel walls of interlobular arteries to the terminal portions of afferent arterioles in a wavelike pattern. Since the mechanisms responsible for the developmental deactivation of renin expression are as yet unknown, we hypothesized that the developing renin-angiotensin system (RAS) may downregulate itself via negative feedback to prevent overactivity of renin. To test for a possible role of angiotensin II in the developmental deactivation of renin expression, we studied the development of intrarenal renin expression in mice lacking ANG II

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Wang, He Yun, Ya Kai Feng, Hai Yang Zhao, Ruo Fang Xiao, and Jin Tang Guo. "Biomimetic Hemocompatible Nanofibrous Scaffolds as Potential Small-Diameter Blood Vessels by Bilayering Electrospun Technique." Advanced Materials Research 306-307 (August 2011): 1627–30. http://dx.doi.org/10.4028/www.scientific.net/amr.306-307.1627.

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In this paper, we prepared a scaffold composed of a polyurethane (PU) fibrous outside-layer and a gelatin-heparin fibrous inner-layer with mimicking morphology and mechanical properties of a native blood vessel by sequential bilayering electrospinning technology on a rotating mandrel-type collector. The scaffolds achieved the appropriate breaking strength (3.7 ± 0.13 MPa) and elongation at break (110 ± 8%). When the scaffolds were immersed in water for 1 h, the breaking strength decreased slightly to 2.2 ± 0.3 MPa, but the elongation at break increased up to 145 ± 21%. Heparin was released fro

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Lee, Sunyoung, Shahla M. Jilani, Ganka V. Nikolova, Darren Carpizo, and M. Luisa Iruela-Arispe. "Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors." Journal of Cell Biology 169, no. 4 (2005): 681–91. http://dx.doi.org/10.1083/jcb.200409115.

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Vascular endothelial growth factor (VEGF) is a critical mediator of blood vessel formation during development and in pathological conditions. In this study, we demonstrate that VEGF bioavailability is regulated extracellularly by matrix metalloproteinases (MMPs) through intramolecular processing. Specifically, we show that a subset of MMPs can cleave matrix-bound isoforms of VEGF, releasing soluble fragments. We have mapped the region of MMP processing, have generated recombinant forms that mimic MMP-cleaved and MMP-resistant VEGF, and have explored their biological impact in tumors. Although

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Loudon, Catherine, Elizabeth C. Davis-Berg, and Jason T. Botz. "A laboratory exercise using a physical model for demonstrating countercurrent heat exchange." Advances in Physiology Education 36, no. 1 (2012): 58–62. http://dx.doi.org/10.1152/advan.00094.2011.

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A physical model was used in a laboratory exercise to teach students about countercurrent exchange mechanisms. Countercurrent exchange is the transport of heat or chemicals between fluids moving in opposite directions separated by a permeable barrier (such as blood within adjacent blood vessels flowing in opposite directions). Greater exchange of heat or chemicals between the fluids occurs when the flows are in opposite directions (countercurrent) than in the same direction (concurrent). When a vessel loops back on itself, countercurrent exchange can occur between the two arms of the loop, min

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Cardinal, Kristen O'Halloran, and Stuart K. Williams. "Assessment of the Intimal Response to a Protein-Modified Stent in a Tissue-Engineered Blood Vessel Mimic." Tissue Engineering Part A 15, no. 12 (2009): 3869–76. http://dx.doi.org/10.1089/ten.tea.2009.0193.

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Sahrawat, Tammanna R., and Deepyan Chatterjee. "Time-Dependent Model to Mimic Acetylcholine Induced Vasodilatation in Arterial Smooth Muscle Cells." International Letters of Natural Sciences 52 (March 2016): 60–66. http://dx.doi.org/10.18052/www.scipress.com/ilns.52.60.

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Computational approaches for spatial modeling of dynamics of the intercellular distribution of molecules can parse, simplify, classify and organize the spatiotemporal richness of any biochemical pathway and demonstrate its impact on the cells function by simply coupling it with the downstream effecters. One such online system biology modeling package is Virtual cell that provides a unique open source software and it’s used for making mathematical models to simulate the cytoplasmic control of molecule that interact to produce certain cellular behavior. In our present study, a spatial model for

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Berekashvili, Ketevan, Alicia M. Zha, Mohammed Abdel-Al, et al. "Emergency Medicine Physicians Accurately Select Acute Stroke Patients for Tissue-Type Plasminogen Activator Treatment Using a Checklist." Stroke 51, no. 2 (2020): 663–65. http://dx.doi.org/10.1161/strokeaha.119.026948.

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Background and Purpose— There is uncertainty among many emergency medicine physicians about the decision to give intravenous tPA (tissue-type plasminogen activator), which limits its use. A checklist approach has been suggested as a solution. We compared agreement on tPA treatment in suspected acute ischemic stroke patients between emergency medicine residents (EMRs) using a checklist and vascular neurology fellows (VNFs). Methods— Every suspected acute stroke patient brought to our comprehensive stroke center emergency room within 4.5 hours from symptom onset was prospectively evaluated simul

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Cornelissen, Bart M. W., Eva L. Leemans, Bram F. Coolen, et al. "Insufficient slow-flow suppression mimicking aneurysm wall enhancement in magnetic resonance vessel wall imaging: a phantom study." Neurosurgical Focus 47, no. 1 (2019): E19. http://dx.doi.org/10.3171/2019.4.focus19235.

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OBJECTIVEMR vessel wall imaging (VWI) is increasingly performed in clinical settings to support treatment decision-making regarding intracranial aneurysms. Aneurysm wall enhancement after contrast agent injection is expected to be related to aneurysm instability and rupture status. However, the authors hypothesize that slow-flow artifacts mimic aneurysm wall enhancement. Therefore, in this phantom study they assess the effect of slow flow on wall-like enhancement by using different MR VWI techniques.METHODSThe authors developed an MR-compatible aneurysm phantom model, which was connected to a

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Zhou, Juan, Huiyan Ying, Mingyu Wang, Dandan Su, Guozhong Lu, and Jinghua Chen. "Dual layer collagen-GAG conduit that mimic vascular scaffold and promote blood vessel cells adhesion, proliferation and elongation." Materials Science and Engineering: C 92 (November 2018): 447–52. http://dx.doi.org/10.1016/j.msec.2018.06.072.

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de Greef, W. J., J. de Koning, A. M. I. Tijssen, and B. Karels. "Levels of LH-releasing hormone in hypophysial stalk plasma during an oestrogen-stimulated surge of LH in ovariectomized rats." Journal of Endocrinology 112, no. 3 (1987): 351–59. http://dx.doi.org/10.1677/joe.0.1120351.

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ABSTRACT Treatment of ovariectomized rats with 50 μg oestradiol benzoate, followed by 20 μg oestradiol benzoate 3 days later, induced surges of LH and FSH on the day following the second injection with oestradiol benzoate. During this surge of gonadotrophins, which was not blocked by the anaesthetic required to collect hypophysial stalk blood, increased hypophysial stalk plasma levels of immunoreactive LHRH were noted. Furthermore, the levels of LHRH in hypophysial portal blood were found to fluctuate. Measurement of LHRH in a pool of portal plasma revealed similar results when determined by r

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Cai, Shengze, He Li, Fuyin Zheng, et al. "Artificial intelligence velocimetry and microaneurysm-on-a-chip for three-dimensional analysis of blood flow in physiology and disease." Proceedings of the National Academy of Sciences 118, no. 13 (2021): e2100697118. http://dx.doi.org/10.1073/pnas.2100697118.

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Understanding the mechanics of blood flow is necessary for developing insights into mechanisms of physiology and vascular diseases in microcirculation. Given the limitations of technologies available for assessing in vivo flow fields, in vitro methods based on traditional microfluidic platforms have been developed to mimic physiological conditions. However, existing methods lack the capability to provide accurate assessment of these flow fields, particularly in vessels with complex geometries. Conventional approaches to quantify flow fields rely either on analyzing only visual images or on enf

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Unterleuthner, Daniela, Nina Kramer, Karoline Pudelko, Alexandra Burian, Markus Hengstschläger, and Helmut Dolznig. "An Optimized 3D Coculture Assay for Preclinical Testing of Pro- and Antiangiogenic Drugs." SLAS DISCOVERY: Advancing the Science of Drug Discovery 22, no. 5 (2017): 602–13. http://dx.doi.org/10.1177/2472555216686529.

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Angiogenesis is a promising target for anticancer therapies, but also for treating other diseases with pathologic vessel development. Targeting the vascular endothelial growth factor (VEGF) pathway did not proof as effective as expected due to emerging intrinsic resistance mechanisms, as well as stromal contributions leading to drug insensitivity. Therefore, alternative strategies affecting the interaction of endothelial cells (ECs) with other stromal cells seem to be more promising. Human preclinical in vitro angiogenesis models successfully recapitulating these interactions are rare, and two

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Jiang, Nan N., Demetrios J. Sahlas, Crystal Fong, Wei Wu, Sandra Monteiro, and Ramiro Larrazabal. "Radiographic horizontal gaze deviation in the setting of acute PICA territory ischemia: A potential mimic of large vessel occlusion." Journal of the Neurological Sciences 420 (January 2021): 117226. http://dx.doi.org/10.1016/j.jns.2020.117226.

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Burbank, Lindsey P., and Drake C. Stenger. "The DinJ/RelE Toxin-Antitoxin System Suppresses Bacterial Proliferation and Virulence of Xylella fastidiosa in Grapevine." Phytopathology® 107, no. 4 (2017): 388–94. http://dx.doi.org/10.1094/phyto-10-16-0374-r.

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Xylella fastidiosa, the causal agent of Pierce’s disease of grapes, is a slow-growing, xylem-limited, bacterial pathogen. Disease progression is characterized by systemic spread of the bacterium through xylem vessel networks, causing leaf-scorching symptoms, senescence, and vine decline. It appears to be advantageous to this pathogen to avoid excessive blockage of xylem vessels, because living bacterial cells are generally found in plant tissue with low bacterial cell density and minimal scorching symptoms. The DinJ/RelE toxin-antitoxin system is characterized here for a role in controlling ba

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Belgaumkar, Vasudha A., Ravindranath B. Chavan, Nitika S. Deshmukh, and Ranjitha K. Gowda. "The enigma of adult onset Henoch Schoenlein purpura and leucocytoclastic Vasculits: a case report." International Journal of Research in Dermatology 7, no. 3 (2021): 482. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20211718.

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<p class="abstract">Leukocytoclastic vasculitis (LCV), also known as hypersensitivity vasculitis is a small vessel inflammatory disease which mainly involves the postcapillary venules. It can be idiopathic or secondary to connective tissue diseases, infection, malignancy. A 39 year old male presented with a recurrent episode of multiple palpable purpurae over the legs, trunk, back and upper limbs with diffuse abdominal pain, bloody diarrhoea and arthralgia. Anti-nuclear antibodies (ANA) were positive, but ANA profile was equivocal. Histopathological examination confirmed leukocytoclastic

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Mukhopadhyay, Subrata, Mani Shankar Mandal, and Swati Mukhopadhyay. "Numerical simulation of physiologically relevant pulsatile flow of blood with shear-rate-dependent viscosity in a stenosed blood vessel." International Journal of Biomathematics 11, no. 06 (2018): 1850082. http://dx.doi.org/10.1142/s1793524518500821.

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Pulsatile flow of blood in a blood vessel having time-dependent shape (diameter) is investigated numerically in order to understand some important physiological phenomena in arteries. A smooth axi-symmetric cosine shaped constriction is considered. To mimic the realistic situation as far as possible, viscosity of blood is taken to be non-uniform, a shear-thinning viscosity model is considered and a physiologically relevant pulsatile flow is introduced. Taking advantage of axi-symmetry in the proposed problem, the stream function–vorticity formulation is used to solve the governing equations fo

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Crawley, James, Jian-Ming Gu, Gary Ferrell, and Charles Esmon. "Distribution of Endothelial Cell Protein C/Activated Protein C Receptor (EPCR) During Mouse Embryo Development." Thrombosis and Haemostasis 88, no. 08 (2002): 259–66. http://dx.doi.org/10.1055/s-0037-1613196.

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SummaryThe endothelial cell protein C receptor (EPCR) augments protein C activation by the thrombomodulin•thrombin complex. Deletion of the EPCR gene in mice has been reported to lead to embryonic lethality before embryonic day 10 (E10.0). To identify potential mechanisms responsible for this lethality, we performed an immunohistological analysis of EPCR distribution during mouse embryogenesis. EPCR was detected in the trophoblast giant cells at the feto-maternal boundary from E7.5 and at later time points in the trophoblasts of the placenta, suggesting a role in the haemostatic regulation of

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Yang, Ke, Xing Liu, Wanwen Lin, Yuanyuan Zhang, and Chaoquan Peng. "Upregulation of MicroRNA-125b Leads to the Resistance to Inflammatory Injury in Endothelial Progenitor Cells." Cardiology Research and Practice 2020 (September 14, 2020): 1–7. http://dx.doi.org/10.1155/2020/6210847.

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Objectives. MicroRNA-125b (miR-125b) has been recognized as one of the key regulators of the inflammatory responses in cardiovascular diseases recently. This study sought to dissect the role of miR-125b in modulating the function of endothelial progenitor cells (EPCs) in the inflammatory environment of ischemic hearts. Methods. EPCs were cultured and transfected with miR-125b mimic and negative control mimic. Cell migration and adhesion assays were performed after tumor necrosis factor-α (TNF-α) treatment to determine EPC function. Cell apoptosis was analyzed by flow cytometry. The activation

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Schafer, Christopher M., Jami M. Gurley, Katarzyna Kurylowicz, et al. "An inhibitor of endothelial ETS transcription factors promotes physiologic and therapeutic vessel regression." Proceedings of the National Academy of Sciences 117, no. 42 (2020): 26494–502. http://dx.doi.org/10.1073/pnas.2015980117.

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During the progression of ocular diseases such as retinopathy of prematurity and diabetic retinopathy, overgrowth of retinal blood vessels results in the formation of pathological neovascular tufts that impair vision. Current therapeutic options for treating these diseases include antiangiogenic strategies that can lead to the undesirable inhibition of normal vascular development. Therefore, strategies that eliminate pathological neovascular tufts while sparing normal blood vessels are needed. In this study we exploited the hyaloid vascular network in murine eyes, which naturally undergoes reg

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Ryan, Michael J., T. Taylor Coleman, Jennifer M. Sasser, Katarina M. Pittman, Michael W. Hankins, and David E. Stec. "Vascular smooth muscle-specific deletion of the leptin receptor attenuates leptin-induced alterations in vascular relaxation." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 310, no. 10 (2016): R960—R967. http://dx.doi.org/10.1152/ajpregu.00336.2015.

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Obesity is a risk factor for cardiovascular disease and is associated with increased plasma levels of the adipose-derived hormone leptin. Vascular smooth muscle cells (VSMC) express leptin receptors (LepR); however, their physiological role is unclear. We hypothesized that leptin, at levels to mimic morbid obesity, impairs vascular relaxation. To test this, we used control and VSM-LepR knockout mice (VSM-LepR KO) created with a tamoxifen-inducible specific Cre recombinase to delete the LepR gene in VSMC. Control (10–12 wk old) and VSM-LepR KO (10–12 wk old) mice were fed a diet containing tamo

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Zaucha, Michael T., Robert Gauvin, Francois A. Auger, Lucie Germain, and Rudolph L. Gleason. "Biaxial biomechanical properties of self-assembly tissue-engineered blood vessels." Journal of The Royal Society Interface 8, no. 55 (2010): 244–56. http://dx.doi.org/10.1098/rsif.2010.0228.

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Along with insights into the potential for graft success, knowledge of biomechanical properties of small diameter tissue-engineered blood vessel (TEBV) will enable designers to tailor the vessels' mechanical response to closer resemble that of native tissue. Composed of two layers that closely mimic the native media and adventitia, a tissue-engineered vascular adventitia (TEVA) is wrapped around a tissue-engineered vascular media (TEVM) to produce a self-assembled tissue-engineered media/adventia (TEVMA). The current study was undertaken to characterize the biaxial biomechanical properties of

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Park, Hyung Sub, In Mok Jung, Geum Hee Choi, Soli Hahn, Young Sun Yoo, and Taeseung Lee. "Modification of a Rodent Hindlimb Model of Secondary Lymphedema: Surgical Radicality versus Radiotherapeutic Ablation." BioMed Research International 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/208912.

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Secondary lymphedema is an intractable disease mainly caused by damage of the lymphatic system during surgery, yet studies are limited by the lack of suitable animal models. The purpose of this study was to create an improved model of secondary lymphedema in the hindlimbs of rodents with sustained effects and able to mimic human lymphedema. This was achieved by combining previously reported surgical methods and radiation to induce chronic lymphedema. Despite more radical surgical destruction of superficial and deep lymphatic vessels, surgery alone was not enough to sustain increased hindlimb v

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Monzo, Pascale, Yuk Kien Chong, Charlotte Guetta-Terrier, et al. "Mechanical confinement triggers glioma linear migration dependent on formin FHOD3." Molecular Biology of the Cell 27, no. 8 (2016): 1246–61. http://dx.doi.org/10.1091/mbc.e15-08-0565.

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Glioblastomas are extremely aggressive brain tumors with highly invasive properties. Brain linear tracks such as blood vessel walls constitute their main invasive routes. Here we analyze rat C6 and patient-derived glioma cell motility in vitro using micropatterned linear tracks to mimic blood vessels. On laminin-coated tracks (3–10 μm), these cells used an efficient saltatory mode of migration similar to their in vivo migration. This saltatory migration was also observed on larger tracks (50–400 μm in width) at high cell densities. In these cases, the mechanical constraints imposed by neighbor

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Yalcin Enis, Ipek, Telem Gok Sadikoglu, Jana Horakova, and David Lukas. "The post-morphological analysis of electrospun vascular grafts following mechanical testing." Journal of Polymer Engineering 38, no. 6 (2018): 525–35. http://dx.doi.org/10.1515/polyeng-2017-0157.

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AbstractVascular grafts provide promising scaffolds for patients recuperating from cardiovascular diseases. Since it is necessary to mimic the native vessel in order to overcome the limitations of currently employed synthetic prostheses, researchers are tending to focus on the design of electrospun biodegradable multi-layer scaffolds which involves varying either the polymer type or constructional properties in each layer which, in turn, reveals the importance of layer interactions and their composite effect on the final multi-layer graft. This study describes the fabrication of biodegradable

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Choi, Jin-Ha, Mallesh Santhosh, and Jeong-Woo Choi. "In Vitro Blood–Brain Barrier-Integrated Neurological Disorder Models Using a Microfluidic Device." Micromachines 11, no. 1 (2019): 21. http://dx.doi.org/10.3390/mi11010021.

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The blood–brain barrier (BBB) plays critical role in the human physiological system such as protection of the central nervous system (CNS) from external materials in the blood vessel, including toxicants and drugs for several neurological disorders, a critical type of human disease. Therefore, suitable in vitro BBB models with fluidic flow to mimic the shear stress and supply of nutrients have been developed. Neurological disorder has also been investigated for developing realistic models that allow advance fundamental and translational research and effective therapeutic strategy design. Here,

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Chang, Shu-Chun, and Wei-Chung Vivian Yang. "Hyperglycemia Induces Altered Expressions of Angiogenesis Associated Molecules in the Trophoblast." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/457971.

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We previously reported that the increased level of perlecan with altered glycosaminoglycan (GAG) substitution was present in the placenta with gestational diabetes mellitus (GDM) and in the trophoblasts cultured under hyperglycemic condition. Trophoblast is the first cell lineage to differentiate, invasive, and migrate into the vessel tissues of placenta and fetal membrane during pregnancy. Therefore, active matrix remodeling and vessel formation must occur during placentation. In this study, we further investigated whether hyperglycemia-induced alterations of perlecan in the extracellular mat

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Reinisch, Andreas, Nicole A. Hofmann, Anna C. Obenauf, et al. "Making Functional Endothelial Progenitors: Humanized Large-Scale Animal Serum-Free Propagated Adult Blood-Derived Endothelial Colony-Forming Cells Assemble Stable Perfused Vessels in Vivo." Blood 112, no. 11 (2008): 1882. http://dx.doi.org/10.1182/blood.v112.11.1882.1882.

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Abstract Circulating angiogenic cells (CACs) and several related hematopoietic cell types can mimic an endothelial progenitor cell (EPC) phenotype and facilitate vascular regeneration mainly by humoral and cell mediated support functions but do not form vessels. Despite a documented risk of tumor support and pre-metastatic niche formation, various types of hematopoietic CACs are currently tested in ongoing clinical trials. In sharp contrast, endothelial colony forming cells (ECFCs) have recently been described as the prototype of blood- and vessel-derived EPCs with a robust proliferative poten

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