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Dissertations / Theses on the topic 'Veterinary Toxicology and Pharmacology'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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1

Rawal, Sumit. "Mechanisms of the Extreme Sensitivity of Turkeys to Aflatoxin B1." DigitalCommons@USU, 2010. https://digitalcommons.usu.edu/etd/568.

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The pathogenesis of hepatotoxic and hepatocarcinogenic actions of the mycotoxin aflatoxin B1 (AFB1) involves initial bioactivation by microsomal cytochrome P450s (P450) to a reactive and electrophilic intermediate, exo-aflatoxin B1-8,9-epoxide (exo-AFBO). Poultry, especially turkeys, are extremely sensitive to AFB1, a condition associated with efficient epoxidation by P450s. The purpose of this research was to 1) discover and characterize the P450s in turkey liver responsible for AFB1 bioactivation, and 2) determine the relative importance of these P450s in turkey liver. Initial investigatio

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2

Thomas, Sarah Elizabeth. "A Prevalence Study of Southeast Origin Sale Barn Beef Cattle, Comingled in Warren County, Kentucky, Persistently Infected with Bovine Viral Diarrhea Virus, including the Effects of Season and Body Weight." TopSCHOLAR®, 2011. http://digitalcommons.wku.edu/theses/1070.

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Bovine viral diarrhea (BVD) is an economically important disease of cattle. Calves persistently infected (PI) with the bovine viral diarrhea virus (BVDV) are a powerful agent for spread of the virus. A total of 24,423 southeast origin beef cattle comingled at three Warren County, Kentucky locations were tested from November 2007 to June 2010 for PI BVDV. A total of 97 head tested positive for PI BVDV, giving an average overall prevalence of 0.397%. Calves tested were subdivided into categories for additional calculations of dependence. A total of 8,910 were categorized by weight range upon te

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3

Monteiro, Davolli Gabriel. "REVERSIBLE DOWNREGULATION OF HYPOTHALAMIC-PITUITARY-GONADAL AXIS IN THE STALLION WITH A THIRD-GENERATION GNRH ANTAGONIST." UKnowledge, 2015. http://uknowledge.uky.edu/gluck_etds/22.

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The objectives of this thesis were: (1) to evaluate the downregulation of the stallion hypothalamic-pituitary-gonadal (HPG) axis by a GnRH antagonist (acyline) based upon endocrine, seminal, testicular and behavioral effects, and (2) to assess recovery after treatment. Stallions were treated for 50 days (n=4; 330µg/kg acyline q 5d) and controls (n=4) received vehicle alone. Stallions were assessed pre-treatment and for 72 days after last treatment. Treatment induced declines (p<0.05) in FSH, LH, testosterone (to castrate levels) and estrone sulfate. Gonadotropins and testosterone returned to c

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4

Zhu, Wenying. "GLUCOCORTICOID-INDUCED CHONDROCYTE CYTOTOXICITY AT DOSES RECOMMENDED FOR INTRA-ARTICULAR THERAPY IN HORSES." UKnowledge, 2015. http://uknowledge.uky.edu/gluck_etds/23.

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Intra-articular glucocorticoid injections are commonly used to treat synovitis and osteoarthritis in horses. These agents are highly effective at relieving pain, swelling, and other symptoms of joint inflammation. The drugs also have therapeutic benefits by down regulating the expression of cytokines and protease enzymes that participate in the degradation of articular cartilage. However, detrimental effects on chondrocyte function and cell viability that is independent of osteoarthritis pathogenesis have been described and linked to glucocorticoid use. These side effects are both drug- and do

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5

Taylor, Victoria A. "PHYSIOLOGICAL CHANGES ASSOCIATED WITH PREGNANT OR NONPREGNANT MARES GRAZING PASTURES OF ORCHARDGRASS-BLUEGRASS, KENTUCKY 31 TALL FESCUE INFECTED WITH EPICHLOË COENOPHIALA, OR KYFA9821 TALL FESCUE INFECTED WITH THE NOVEL ENDOPHYTE AR584." UKnowledge, 2017. https://uknowledge.uky.edu/gluck_etds/33.

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Kentucky 31 tall fescue (KY31) infected with the common toxic endophyte strains of Epichloё coenophiala produces toxic alkaloids that improve plant vigor, but cause numerous adverse effects in grazing animals. Researchers developed a variety of KY31 containing an alternative strain of E. coenophiala, termed novel endophyte (NE). Adverse health effects in mares have not been evaluated. Experiments in this thesis tested the hypothesis that the NE pasture does not cause adverse effects typically associated with KY31. Specific aims were to: 1) compare forage ergovaline concentrations between KY31

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6

Sargeant, Aaron Matthew. "Preclinical Efficacy and Safety Evaluation of Novel Small-Molecule Targeted Agents for the Prevention and Treatment of Prostate Cancer." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1243948876.

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7

Al-Amer, Saleh Suliaman. "Nutritional and toxicological studies on New Zealand mutton bird meat (Puffinus griseus)." Lincoln University, 2009. http://hdl.handle.net/10182/1659.

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New Zealand mutton bird or tītī (Puffinus griseus and order procellariiformes) nest in New Zealand during the summer months, migrate to the northern hemisphere during May and return in September. Their eggs are laid during November and December and the chicks are hatched in the following January and February. Large numbers of them are harvested from April to May in New Zealand. They are wild seabirds annually harvested by Maori according to the customary rights agreement set by Treaty of Waitangi.NZ mutton birds also called Sooty Shearwaters are noted for their high proportion of body fat.Thes

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8

Winstanley, Peter Andrew. "The pharmacology and toxicology of amodiaquine." Thesis, University of Liverpool, 1988. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.237571.

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9

Lepera, Michael Anthony. "Response of Monovalent Cation Transporters to Pro-apoptotic Protein Kinase C Modulators in Human Lens Epithelial Cells." Wright State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=wright1314376525.

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10

Wang, Jinju. "Differentiation of Megakaryocytes/Platelets and Neurons from Human Endometrial Stromal Progenitor Cells." Wright State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=wright1314976408.

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11

Alghamri, Mahmoud. "Enhanced Angiotensin II-Induced Cardiac and Aortic Remodeling in ACE2 Knockout Mice." Wright State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=wright1343838851.

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12

Martin, Richard John. "Veterinary pharmacology, ion-channels and anthelmintics." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/30450.

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In this collection of papers modes of action of anthelmintic and anaesthetic drugs used in Veterinary Practice are investigated using electrophysiological techniques. New preparations and analytical techniques for investigation are described along with properties of ion-channel target sites. The pharmacology of piperazine, levamisole, pyrantel, morantel, oxtantel, avermectins, cyclic depsipeptides, ketamine, metomidate, alphaxalone and xylazine are studied. This information is reviewed in formats suitable for graduate and undergraduate study. Two-micropipette current-clamp and voltage-clamp te

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13

Brown, Larry Dale. "Subchronic bioavailability and disposition of bivalent lead in pregnant swine and fetuses." free to MU campus, to others for purchase, 1998. http://wwwlib.umi.com/cr/mo/fullcit?p9901221.

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14

Cooper, Rose. "Behavior of Gold Nanoparticles in Physiological Environment and the Role of Agglomeration and Fractal Dimension." Wright State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1440168780.

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15

Chmura, Douglas F. "Response of Neuroinflammatory and Neurodegenerative Markers Following Sub-lethal Sarin Exposure and Subsequent Treatment via an in-vivo Caspase Inhibitor." Wright State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=wright1324414961.

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16

Vicente, Carrillo Alejandro. "Sperm Membrane Channels, Receptors and Kinematics : Using boar spermatozoa for drug toxicity screening." Doctoral thesis, Linköpings universitet, Avdelningen för kliniska vetenskaper, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-131862.

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Internal fertilization usually implies that a spermatozoon, with intact attributes for zygote formation, passes all hurdles during its transport through the female genitalia and reaches the oocyte. During this journey, millions to billions of other spermatozoa perish. Spermatozoa are highly differentiated motile cells without synthetic capabilities. They generate energy via glycolysis and oxidative phosphorylation to sustain motility and to maintain the stability and functionality of their plasma membrane. In vivo, they spend their short lifespan bathing in female genital tract fluids of diffe

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17

Coleman, M. D. "The biochemical pharmacology and toxicology of anti-parasitic agents." Thesis, Aston University, 2004. http://publications.aston.ac.uk/21356/.

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18

Schnapp, Alaina M. "The Effects of Benzyl Alcohol on Developing Zebrafish (Danio rerio)." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1365083632.

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19

Aal-Aaboda, Munaf Sabah. "Glutamate Transporter 1 and Cystine-Glutamate Antiporter as Potential Targets for Attenuating Alcohol Consumption in Male P Rats." University of Toledo Health Science Campus / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=mco1403010118.

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20

Alasmari, Fawaz Fayez. "Effects of Beta-Lactam Antibiotics on Cystine /Glutamate Exchanger Transporter and Glutamate Transporter 1 Isoforms as well as Ethanol Drinking Behavior in Male P Rats." University of Toledo Health Science Campus / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=mco1435826676.

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21

McIntosh, Kyle Douglas. "Pharmaceutical applications and toxicity of extracted alkenones from marine Isochrysis algae." University of Toledo Health Science Campus / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=mco1564780576118206.

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22

Duffin, Roger. "Molecular toxicology studies on the quartz hazard." Thesis, Edinburgh Napier University, 2003. http://researchrepository.napier.ac.uk/Output/2777.

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Silicon makes up almost 28% of the Earth's crust and within that crust, quartz (crystalline silica) is one of the most abundant minerals. Exposure to quartz can occur in a number of occupations, including the mining and construction industries in which respirable quartz particles are generated and become airborne. Inhalation of quartz can lead to the fibrosing lung disease silicosis and cancer. Silicosis has been recognised for many decades as one of the most prevalent occupational lung diseases. In 1997, an IARC working Group classified quartz as a class 1 lung carcinogen, but only in some in

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23

Israel, Davelene Davinah. "Differential Signaling and Gene Regulation Among Three Human EP3 Prostanoid Receptor Isoforms." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/196148.

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Prostaglandin E2 (PGE2) is a hormone derived from the metabolism of arachidonic acid whose functions include regulation of platelet aggregation, fever and smooth muscle contraction/relaxation. PGE2 mediates its physiological and pathophysiological effects through its binding to four G-protein coupled receptor subtypes, named EP1, EP2, EP3 and EP4. The EP3 prostanoid receptor is unique in that it has multiple isoforms generated by alternative mRNA splicing. These splice variants display differences in tissue expression, constitutive activity and regulation of signaling molecules. To date there

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24

Wu, Tongde. "Post-Transcriptional Regulation of Nrf2: Novel Mechanisms beyond Keap1." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/301750.

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Nrf2 (NF-E2-related factor 2) is a transcription factor that regulates a battery of downstream genes that contain the antioxidant response element (ARE) in their promoter regions, including intracellular redox-balancing proteins, phase II detoxifying enzymes, and transporters. These Nrf2-dependent proteins work in collaboration to protect against many diseases where oxidative stress plays an essential role in disease onset and progression. Consequently, it is imperative to understand the basic molecular mechanisms of how Nrf2 is regulated so that this pathway can be targeted for disease preven

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25

Qiao, Shuxi. "Pharmacological Modulation of Oxidative and Proteotoxic Stress for Antimelanoma Intervention." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/311348.

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Cumulative evidence suggests that constitutively elevated levels of proteotoxic stress represent a specific vulnerability of malignant cells that can be targeted by pharmacological modulation of the intracellular proteotoxic stress response. According to this emerging mechanism, small molecule stress modulators may induce deviations from protein homeostasis causing cytotoxicity confined to malignant cells already at a high set point of constitutive proteotoxic stress leading to functional impairment and even cell death. In contrast, normal cells with sufficient protein degradation capacity can

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26

Sollome, James Jerome. "Heregulin Activates a Novel HER2/HER3-MTK1-GIT1/ERK1/2 MAPK Signaling Pathway." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/315554.

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Human MAP3K4 (MTK1) functions upstream of mitogen activated protein kinases (MAPKs). In the studies presented herein, MTK1 is shown to be required for human epidermal growth factor receptor 2/3 (HER2/HER3)-heregulin beta1 (HRG) induced extracellular acidification and cell migration in MCF-7 breast cancer cells. Furthermore, it was shown that HRG stimulation leads to association of MTK1 with tyrosine phosphorylated HER3 in MCF-7 and T-47D breast cancer cells. The MTK1/HER3 association was dependent on HER2 activation and was decreased by pre-treatment with the HER2 inhibitor, lapatinib. Further

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27

Alamri, Mohammed A. "Syntheses and Evaluations of Bicycloheptylamines and Cyclohexylamines as Sigma-2 Receptor Ligands and Their Potential as Anticancer Agents." Thesis, University of the Sciences in Philadelphia, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10631480.

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<p> Sigma-2 receptors are a new target in cancer research. These receptors tend to be overexpressed in cancers compared to normal tissue, this expression is also high during proliferation. Fluorescent and radio-labeled sigma-2 receptors show increased uptake in tumors, and this uptake seems to be largely endocytotic. Many sigma-2 receptor ligands demonstrated anticancer properties either as sole treatments or adjunct therapies where they act as chemosensitizers that increase the activity of DNA-targeting drugs. Some sigma-2 receptors ligands have been utilized as cancer-selective, cargo-delive

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28

Tillotson, Joseph, and Joseph Tillotson. "Targeting Enzymes Involved in Protein Translation and Quality Control as Potential Cancer Therapeutics." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/621777.

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Activation of pathways resulting in an overexpression of oncoproteins, reliant on cap-dependent translation, or mutations of key proteins in a pathway can be advantageous to cancer cells but creates heightened protein quality control pressure. Because of this, there has been an interest in targeting enzymes involved in protein synthesis and protein quality control: such as the eukaryotic initiation factor, eIF4A, a DEAD-box RNA helicase involved in translation initiation, and p97, an AAA+ chaperone involved in protein quality control. Despite some successes in discovering both eIF4A and p97 in

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29

Hume, Wyatt Roderic. "Studies on the pharmacology and toxicology of materials applied to dentine /." Title page, contents and abstract only, 1988. http://web4.library.adelaide.edu.au/theses/09D/09dh922.pdf.

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30

MONTGOMERY, DAVID WESLEY. "IMMUNOLOGY, PHARMACOLOGY AND TOXICOLOGY OF THE IMMUNOSUPPRESSIVE CYCLIC PEPTIDE, DIDEMNIN B." Diss., The University of Arizona, 1986. http://hdl.handle.net/10150/183982.

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Didemnin B (DB) is a seven amino acid cyclic polypeptide (NSC-325319), MW 1112, isolated from a Caribbean tunicate of the family didemnidae (Trididemnum genus). In vitro assays of murine splenic mononuclear cell (MNC) proliferation showed that DB potently inhibited the mixed lymphocyte reaction (IC₅₀ = < 10 pg/ml), concanavalin A (Con A; IC₅₀ = 50 pg/ml) and lipopolysaccharide (IC₅₀ = < 100 pg/ml) mitogenesis. Proliferation induced by phorbol esters, calcium ionophore and Con A were equipotently inhibited by DB, suggesting that the drug acts upon an intracellular pathway common to these mito

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31

Ruscoe, Julie Elizabeth. "The effect of disposition on the pharmacology and toxicology of antimalarials." Thesis, University of Liverpool, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337126.

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32

Vander, Werf Karie. "Pharmacokinetics and pharmacodynamics of oral meloxicam tablets in healthy horses." Thesis, Kansas State University, 2013. http://hdl.handle.net/2097/15314.

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Master of Science<br>Department of Clinical Sciences<br>Elizabeth Davis<br>The first aim of the current study was to investigate the pharmacokinetics of oral meloxicam tablets and the gastrointestinal and renal effects after a 14-day treatment period. Meloxicam was orally administered to six adult horses once daily at a dosage of 0.6 mg/kg for 14 consecutive days. Blood was collected prior to each administration and at 20 and 40 min, and 1, 2, 4, 8, 12, and 24 hours after administration on days 1, 7, and 14 for the determination of meloxicam plasma concentrations by mass spectrometry. In ad

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33

Schumacher, Stephen A. "The pharmacokinetics and pharmacodynamics of intravenous magnesium sulfate in horses." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1562104626668678.

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34

Locke, Sara Lindsey. "Effect of cytochrome P450 inhibition on pharmacokinetics and toxicity of diclofenac in chickens : unravelling toxicity in Gyps vultures." Diss., University of Pretoria, 2020. http://hdl.handle.net/2263/75858.

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The nonsteroidal anti-inflammatory drug (NSAID) diclofenac was responsible for the decimation of Gyps vulture species on the Indian subcontinent over the last two decades of the 20th century. For an unknown reason, Gyps vultures were extremely sensitive to diclofenac (LD50 ~ 0.1-0.2 mg/kg), with toxicity appearing to be linked to a metabolic deficiency, demonstrated by the long T1/2 (~12-17 h) and low Cl (0.0001-0.0002 L/h*kg). This was in striking comparison to other bird species such as the domestic chicken (Gallus gallus domesticus), where the LD50 is ~10 mg/kg, the T1/2 is ~1 h and the Cl

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35

Javanmard, Sahar. "Synthesis and pharmacology of site-specific cocaine abuse treatment agents." Diss., Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/30952.

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36

Thurmond, Thane S. "Indomethacin Reduces Splenic Red Pulp Macrophage Populations in Female New Zealand White Rabbits." Digital Commons @ East Tennessee State University, 1995. https://dc.etsu.edu/etd/2807.

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In an effort to elucidate the mechanism by which indomethacin (IN) attenuates the stimulatory effect of estradiol (E$\sb2$) on rabbit splenic red pulp macrophages (RPM), thirty-nine female New Zealand White rabbits were divided into 10 groups: ovariectomized (OVX), OVX/IN at 0.1 and 5.0 mg/kg body weight (bw)/day; sham OVX (SOVX), SOVX/IN at 0.1 and 5.0 mg/kg bw/day; OVX/25 mg E2, OVX/25 mg E$\sb2$/IN at 0.1 and 5.0 mg/kg bw/day; intact Control. Quantitative changes in RPM population in response to the treatments were measured using a 0 to 4 histologic grading scale. Estradiol treatment result

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37

ROSA, GUSTAVO A. B. "Estudo dos efeitos do fármaco propranolol para Ceriodaphnia silvestrii (Cladocera, crustacea) com ênfase em efeitos nas populações." reponame:Repositório Institucional do IPEN, 2008. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11679.

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Made available in DSpace on 2014-10-09T12:54:40Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:07:21Z (GMT). No. of bitstreams: 0<br>Dissertação (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energéticas e Nucleares - IPEN/CNEN-SP

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38

Vernetti, Lawrence Allen. "The effect of cyclosporine A on cytokeratin intermediate filament phosphorylation." Diss., The University of Arizona, 1991. http://hdl.handle.net/10150/185577.

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MCF7 cell cultures exposed to cyclosporine A (CsA) from 1-5 μM and from 0-48 hr have decreased viability and clonogenic ability. When these cells are examined by indirect immunofluorescence for cytoskeletal filaments, there is altered cell shape, but no alteration in microfilaments or microtubules. However, there is a collapse in cytokeratin intermediate filament arrays resulting in a peri-nuclear reorganization at 24-48 hr incubation (5 μM). When MCF7 cells are pre-treated in 5 μM CsA for 24 hr, and then placed in non-drug media for 12-24 hr, there is recovery of cytokeratin arrays and cell s

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39

Gunawardhana, Lhanoo. "The role of metabolic activation and oxidant injury in the hepatotoxicity of 1,2-dichlorobenzene in the rat." Diss., The University of Arizona, 1992. http://hdl.handle.net/10150/186039.

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1,2-Dichlorobenzene (1,2-DCB) is a potent hepatotoxicant in the Fischer-344 (F344) rat. Phenobarbital (PB), a known inducer of cytochrome P-450, enhanced the metabolism and covalent binding of 1,2-DCB in F344 rat liver microsomes. Identification of 2,3-dichlorophenol, 3,4-dichlorophenol and dichlorobenzene dihydrodiol indicated the formation of dichlorobenzene epoxides in PB induced microsomes. Moreover, modulation of microsomal metabolism and covalent binding using glutathione, trichloropropene oxide, ascorbic acid and superoxide dismutase implicated quinones as the major covalent binding spe

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40

Brown, Alan Perry. "Generation and expression of halothane derived protein adducts in the guinea pig liver." Diss., The University of Arizona, 1993. http://hdl.handle.net/10150/186218.

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The volatile anesthetic halothane can be bioactivated in the liver to the reactive intermediate, trifluoroacetyl chloride, which is capable of covalently modifying liver protein. The product of this reaction is trifluoroacetyl-N-ε-amino lysine, which can act as a foreign epitope in altering both protein immunogenicity and antigenicity. Protein adduct formation appears to be responsible for the development of both an acute and an immune-mediated hepatotoxicity. The goal of this research project was to detect, quantify, and characterize the formation of protein adducts in the guinea pig liver, f

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41

Mobley, Scott Alven. "Retinol activation of Kupffer cells: A mechanism for potentiation of chemically-induced liver injury." Diss., The University of Arizona, 1993. http://hdl.handle.net/10150/186234.

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The mechanism by which vitamin A (VA, retinol) potentiates the hepatotoxicity of carbon tetrachloride (CCl₄) in male Srague-Dawley rats was investigated. The toxicity of single and repeated doses of CCl₄ was potentiated in rats following VA treatment. CCl₄-induced hepatotoxicity was completely eliminated in control and VA-treated rats by 1-aminobenzotriazole, a cytochrome P-450 inhibitor, indicating that CCl₄ metabolism was necessary to achieve potentiation. To determine if VA-potentiated CCl₄ hepatotoxicity involves retinol activation of Kupffer cells (KC), various parameters were measured as

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42

Wild, Stacie Lynn. "Pyrrolizidine alkaloids: Hepatic metabolism and extrahepatic toxicity." Diss., The University of Arizona, 1994. http://hdl.handle.net/10150/186599.

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Pyrrolizidine alkaloids are proposed to be metabolized in the liver to reactive pyrrole species, or dehydroalkaloids. These reactive pyrroles are hypothesized to be responsible for pyrrolizidine alkaloid toxicity. This dissertation research has established that dehydroalkaloids are, in fact, metabolites of pyrrolizidine alkaloids. It was first determined that dehydromonocrotaline is produced during hepatic microsomal metabolism of monocrotaline and that it has the ability to bind in vitro with a synthetic thiol-containing resin, Thiopropyl Sepharose 6B. Similarly, synthetic dehydromonocrotalin

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43

Collins, Stuart A. "3,4-methylenedioxy-methamphetamine(MDMA)-induced Increases in Hippocampal Glutamate Concentrations and Its Impact on the Dentate Gyrus." University of Toledo Health Science Campus / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=mco1438598527.

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44

Poletti, Jabbour Jamil, Rospigliosi Andrés Wiegering, Elías Reneé Pereyra, and Barrera Carmen Cecilia Elías. "Carbamazepine and oxcarbazepine: reflections after an oxcarbazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis overlap." Springer International Publishing, 2016. http://hdl.handle.net/10757/609483.

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45

Subhahar, Michael. "Pharmacokinetics and pharmacodynamics of some NSAIDs in horses : a pharmacological, biochemical and forensic study." Thesis, University of Central Lancashire, 2013. http://clok.uclan.ac.uk/9244/.

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Non-steroidal anti- inflammatory drugs (NSAIDs) have been in use for over 100 years to treat pain, exerting their analgesic effect by inhibiting prostaglandin (PG) synthesis via the COX pathway. Some of the NSAIDs have adverse side effects including ulceration of the stomach and cardiovascular events which are associated with bleeding. Search is still going on to find a safe NSAID. Two new coxib NSAIDs, namely celecoxib and etoricoxib have been developed and they exert marked beneficial effects in reducing pain in humans and other small animals with little or no side effects. No such study has

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46

Keefer, Edward W. "Unique applications of cultured neuronal networks in pharmacology, toxicology, and basic neuroscience." Thesis, University of North Texas, 2001. https://digital.library.unt.edu/ark:/67531/metadc2797/.

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This dissertation research explored the capabilities of neuronal networks grown on substrate integrated microelectrode arrays in vitro with emphasis on utilizing such preparations in three specific application domains: pharmacology and drug development, biosensors and neurotoxicology, and the study of burst and synaptic mechanisms. Chapter 1 details the testing of seven novel AChE inhibitors, demonstrating that neuronal networks rapidly detect small molecular differences in closely related compounds, and reveal information about their probable physiological effects that are not attainable thro

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47

Nylander, Martina. "The thrombin receptors PAR1 and PAR4 and their relative role in platelet activation." Licentiate thesis, Pharmacology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-19958.

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<p>Many blood cell mechanisms in the human body are working all the time to maintain haemostasis in the blood vessels. Once a wound arises platelets are alerted via different substances to cover the wound and prevent loss of blood. Most of the times these mechanisms do stop the blood, and further heal the wound. During other circumstances the platelet-covering continues to form a thrombus, preventing the blood to flow and instead causes myocardial infarction or stroke. There are several risk factors triggering development of circulatory diseases such as obesity, lack of exercise, smoking, infe

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48

Gunter, Bryan. "Localization and Expression of GFRα2 Receptors in Neonatal and Adolescent Mouse Heart". Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/honors/134.

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Neurturin (NRTN), a member of the glial cell-line derived neurotrophic factor(GDNF) family, is required in the development of parasympathetic cholinergic neurons. It signals through binding to a glycosyl-phophatidyl inositol (GPI)-linked receptor, GDNF family receptor α2 (GFRα2), which couples to Ret tyrosine kinase. Studies of NRTN knockout mice have shown that NRTN is essential for normal cholinergic innervation of the heart, but the precise role of NRTN remains unknown. For NRTN to evoke a biological response, GFRα2 must be localized to the surface of target neurons. The aim of this study w

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49

Amann, Maria. "Anti-tumor activity, pharmacology and toxicology of EpCAM/ CD3-bispecific single-chain antibodies." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-109478.

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Jodrell, Duncan Ian. "The pharmacology and toxicology of novel thymidylate synthase inhibitors, potential new anticancer agents." Thesis, University of Southampton, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296525.

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