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Journal articles on the topic 'Viability of organs as well as tissues'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Sobko, I. V. "The use of infrared thermography for abdominal gunshot wounds." Zaporozhye Medical Journal 26, no. 3 (2024): 258–64. http://dx.doi.org/10.14739/2310-1210.2024.3.298580.

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Aim. To determine the effectiveness of infrared thermography to identify tissue debris of parenchymal organs and in the wound edges of hollow organs to be removed as well as for the surgical treatment of gunshot wounds of the anterior abdominal wall. Materials and methods. The results of the infrared thermography use in the provision of surgical care to 67 wounded at the second level of medical care in the conditions of the Forward Surgical Group of the Military Mobile Hospital were analyzed. Results. Clinical examples and results of the infrared thermography use for the diagnosis and treatmen

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Kumar, Manav Sree, Payal Varma, and Balasubramanian Kandasubramanian. "From lab to life: advances in in-situ bioprinting and bioink technology." Biomedical Materials 20, no. 1 (2024): 012004. https://doi.org/10.1088/1748-605x/ad9dd0.

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Abstract Bioprinting has the potential to revolutionize tissue engineering and regenerative medicine, offering innovative solutions for complex medical challenges and addressing unmet clinical needs. However, traditional in vitro bioprinting techniques face significant limitations, including difficulties in fabricating and implanting scaffolds with irregular shapes, as well as limited accessibility for rapid clinical application. To overcome these challenges, in-situ bioprinting has emerged as a groundbreaking approach that enables the direct deposition of cells, biomaterials, and bioactive fa

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Ostróżka-Cieślik, Aneta. "The Effect of Antioxidant Added to Preservation Solution on the Protection of Kidneys before Transplantation." International Journal of Molecular Sciences 23, no. 6 (2022): 3141. http://dx.doi.org/10.3390/ijms23063141.

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Ischemia–reperfusion injury is a key clinical problem of transplantology. Current achievements in optimizing organ rinse solutions and storage techniques have significantly influenced the degree of graft damage and its survival after transplantation. In recent years, intensive research has been carried out to maintain the viability of tissues and organs outside the integral environment of the body. Innovative solutions for improving the biochemical functions of the stored organ have been developed. The article discusses directions for modifying preservation solutions with antioxidants. Clinica

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Panconesi, Rebecca, Mauricio Flores Carvalho, Matteo Mueller, et al. "Viability Assessment in Liver Transplantation—What Is the Impact of Dynamic Organ Preservation?" Biomedicines 9, no. 2 (2021): 161. http://dx.doi.org/10.3390/biomedicines9020161.

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Based on the continuous increase of donor risk, with a majority of organs classified as marginal, quality assessment and prediction of liver function is of utmost importance. This is also caused by the notoriously lack of effective replacement of a failing liver by a device or intensive care treatment. While various parameters of liver function and injury are well-known from clinical practice, the majority of specific tests require prolonged diagnostic time and are more difficult to assess ex situ. In addition, viability assessment of procured organs needs time, because the development of the

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Gubareva, E. A., E. V. Kuevda, A. Kh Kade, et al. "Quality assessment of decellularization and recellularization of tissue-engineering constructions by the chemiluminescence method." Доклады Академии наук 484, no. 6 (2019): 764–67. http://dx.doi.org/10.31857/s0869-56524846764-767.

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It has been established that indicators of the intensity of chemiluminescence in the native and muscle cellized tissues of rat muscular organs, as well as in their decellularized matrices, can serve as one of the express criteria that allows, along with ultrastructural analysis, to quantify the viability of cell structures in biological samples of the diaphragm.

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Glyantsev, S. P. "Condition of the problem of organ transplantation in the USSR in 1970–1971 and ways to solve it (Yu.M. Lopukhin, A.G. Lapchinsky, V.P. Demikhov)." Transplantologiya. The Russian Journal of Transplantation 15, no. 4 (2023): 541–58. http://dx.doi.org/10.23873/2074-0506-2023-15-4-541-558.

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Aim. The article examines and analyzes the state of the problem of organ transplantation in the USSR in the early 1970s and ways to solve it with the participation of three prominent transplantologists of the Soviet Union – Yu.M. Lopukhin, A.G. Lapchinsky and V.P. Demikhov, as well as some world achievements in this field.Material and methods. Available printed works on the history of Russian and world transplantology in the 1970s, the analysis of which was carried out by historical-genetic and comparative-analytical methods.Results. Developed by Yu.M. Lopukhin together with leading surgeons a

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Tran, Douglas, John Vandenberge, Nancy Kim, Zhongjun Wu, and Bartley Griffith. "431 Allogeneic recellularized lung orthotopic (ARLO) transplant research: A short-term non-survival model." Journal of Clinical and Translational Science 9, s1 (2025): 129. https://doi.org/10.1017/cts.2024.1036.

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Objectives/Goals: This study assesses the feasibility of a human-to-swine lung transplant model for the evaluation of bioengineered organs. Given the critical organ shortage, this research explores bioengineered organs as a potential solution by evaluating early lung function, immune responses, and technical aspects to develop a model for bioengineered lungs. Methods/Study Population: The study employs a non-survival human-to-swine left lung transplant model in an immunosuppressed Yorkshire swine. A combination of cobra venom factor pretreated with methylprednisolone and Benadryl with schedule

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Atia, Gamal Abdel Nasser, Hany K. Shalaby, Naema Goda Ali, et al. "New Challenges and Prospective Applications of Three-Dimensional Bioactive Polymeric Hydrogels in Oral and Craniofacial Tissue Engineering: A Narrative Review." Pharmaceuticals 16, no. 5 (2023): 702. http://dx.doi.org/10.3390/ph16050702.

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Regenerative medicine, and dentistry offers enormous potential for enhancing treatment results and has been fueled by bioengineering breakthroughs over the previous few decades. Bioengineered tissues and constructing functional structures capable of healing, maintaining, and regenerating damaged tissues and organs have had a broad influence on medicine and dentistry. Approaches for combining bioinspired materials, cells, and therapeutic chemicals are critical in stimulating tissue regeneration or as medicinal systems. Because of its capacity to maintain an unique 3D form, offer physical stabil

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Pospelov, Anton D., Olga M. Kutova, Yuri M. Efremov, et al. "Breast Cancer Cell Type and Biomechanical Properties of Decellularized Mouse Organs Drives Tumor Cell Colonization." Cells 12, no. 16 (2023): 2030. http://dx.doi.org/10.3390/cells12162030.

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Tissue engineering has emerged as an indispensable tool for the reconstruction of organ-specific environments. Organ-derived extracellular matrices (ECM) and, especially, decellularized tissues (DCL) are recognized as the most successful biomaterials in regenerative medicine, as DCL preserves the most essential organ-specific ECM properties such as composition alongside biomechanics characterized by stiffness and porosity. Expansion of the DCL technology to cancer biology research, drug development, and nanomedicine is pending refinement of the existing DCL protocols whose reproducibility rema

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Biru, Elena Iuliana, Madalina Ioana Necolau, Adriana Zainea, and Horia Iovu. "Graphene Oxide–Protein-Based Scaffolds for Tissue Engineering: Recent Advances and Applications." Polymers 14, no. 5 (2022): 1032. http://dx.doi.org/10.3390/polym14051032.

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The field of tissue engineering is constantly evolving as it aims to develop bioengineered and functional tissues and organs for repair or replacement. Due to their large surface area and ability to interact with proteins and peptides, graphene oxides offer valuable physiochemical and biological features for biomedical applications and have been successfully employed for optimizing scaffold architectures for a wide range of organs, from the skin to cardiac tissue. This review critically focuses on opportunities to employ protein–graphene oxide structures either as nanocomposites or as biocompl

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Kalyuzhnaya, L. I., M. O. Sokolova, V. E. Chernov, et al. "The effect of the cell-free matrix of the human umbilical cord on the growth dynamics and viability of cultured human and animal cells ex vivo." Genes & Cells 16, no. 3 (2021): 72–79. http://dx.doi.org/10.23868/202110010.

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Due to its extraembryonic origin, the umbilical cord retains regenerative molecules of the fetal phenotype The cell-free matrix of the human umbilical cord as the basis of various tissue-engineering structures (TES) for regenerative medicine can contribute to the repopulation of transplanted matrices by patient-specific cells. The aim of the work was to study in vitro the cytotoxic properties of a tissue-engineered lyophilized cell-free matrix made by the detergent method from the human umbilical cord Warton jelly with respect to human skin fibroblasts, as well as the effect of this matrix on

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Stanishevskaya, O. I., Y. L. Silyukova, and I. I. Mirzakaeva. "PRACTICAL USE OF THE CHORIOALLANTOIC MEMBRANE (CAM) MODEL IN THE CREATION OF A CRYOBANK OF GENERATIVE CELLS OF FEMALE GALLUS GALLUS DOMECTICUS." International Journal of Veterinary Medicine, no. 4 (January 20, 2025): 501–8. https://doi.org/10.52419/issn2072-2419.2024.4.501.

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One of the promising areas for preserving female reproductive cells of the Aves class is the use of embryonic tissues of reproductive organs and cells. Evaluation of the effectiveness of freezing methods for female reproductive organs of birds should be based on simplicity and availability. The chicken chorioallantoic membrane (CAM) model can be an accessible and effective approach to assessing the quality of frozen/ thawed avian ovarian tissues for subsequent orthotopic transplantation. The aim of the study was to determine the age of chicken embryos for obtaining sex-differentiated gonads an

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Mahaparea, APK, G. Srinivas, D.V. Ramanjaneyulu, et al. "Function, Issues of Concern, Health Care Provider as Well as Team Role, Tissue as Well as Organ Selection Along With Processing, Non-Living Donors, Living Donors and Clinical Significance Regarding Tissue and Organ Donation." Journal of Advanced Research and Reviews in Virology & Microbiology 2, no. 1 (2025): 29–39. https://doi.org/10.5281/zenodo.15462763.

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<em>Donating tissue or organs is a multifaceted and intricate process that begins with the careful process of determining death. Following this, a specific set of inclusion/exclusion criteria determines whether or not organs may be obtained from the donor. Ultimately, this leads to a multispecialty transplant and procurement procedure. This exercise clarifies how the donation procedure is assessed and managed and emphasises the part the medical staff plays in post-transplant patient care.</em>

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Hanzalíková, Katarína, Petra Kubizniakova, Lucie Kyselová, and Dagmar Matoulková. "Cryopreservation: The secret of modern preservation of brewer’s yeasts – minireview." KVASNY PRUMYSL 67, no. 1 (2021): 403–8. http://dx.doi.org/10.18832/kp2021.67.403.

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The aim of the long-term preservation of cells, tissues and organs is to maintain their cellular structures and biological functions for as long as possible. Cryopreservation is a process where biological material is stored and preserved at very low temperatures. However, freezing and thawing processes can cause irreversible cell damage, which is related to formation of ice crystals, osmotic stress, accumulation of reactive forms of oxygen, etc. Therefore the cell viability depends mainly on the freezing rate, the composition of the cryoprotective medium as well as on the thawing rate. Using a

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Lopes-Coelho, Filipa, Filipa Martins, Ana Hipólito, et al. "A Metabolic Signature to Monitor Endothelial Cell Differentiation, Activation, and Vascular Organization." Biomedicines 10, no. 9 (2022): 2293. http://dx.doi.org/10.3390/biomedicines10092293.

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The formation of new blood vessels is an important step in the morphogenesis and organization of tissues and organs; hence, the success of regenerative medicine procedures is highly dependent on angiogenesis control. Despite the biotechnological advances, tissue engineering is still a challenge. Regarding vascular network formation, the regulators are well known, yet the identification of markers is pivotal in order to improve the monitoring of the differentiation and proliferation of endothelial cells, as well as the establishment of a vascular network supporting tissue viability for an effic

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Avena, Paola, Lucia Zavaglia, Ivan Casaburi, and Vincenzo Pezzi. "Perfusion Bioreactor Technology for Organoid and Tissue Culture: A Mini Review." Onco 5, no. 2 (2025): 17. https://doi.org/10.3390/onco5020017.

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Organoid culture is an emerging and promising 3D culture system by which three-dimensional cell aggregates have been produced from different organs and tissues. This new innovative culture technology preserves parental gene expression, as well as the biological features of parental cells in vitro and ensures maintenance of three-dimensional cell culture for prolonged periods, opening new encouraged scientific scenarios and making them a functioning and valid system for testing new drugs for tissue engineering studies and precision oncology medicine. Various research focused on organoids has be

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Wolkers, Willem F., and Folkert A. Hoekstra. "In situFTIR Assessment of Desiccation-Tolerant Tissues." Spectroscopy 17, no. 2-3 (2003): 297–313. http://dx.doi.org/10.1155/2003/831681.

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This essay shows how Fourier transform infrared (FTIR) microspectroscopy can be applied to study thermodynamic parameters and conformation of endogenous biomolecules in desiccation-tolerant biological tissues. Desiccation tolerance is the remarkable ability of some organisms to survive complete dehydration. Seed and pollen of higher plants are well known examples of desiccation-tolerant tissues. FTIR studies on the overall protein secondary structure indicate that during the acquisition of desiccation tolerance, plant embryos exhibit proportional increases inα-helical structures and thatµ-shee

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Alexandrova, Krassimira, Carsten Griesel, Marc Barthold, et al. "Large-Scale Isolation of Human Hepatocytes for Therapeutic Application." Cell Transplantation 14, no. 10 (2005): 845–53. http://dx.doi.org/10.3727/000000005783982530.

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During the last decade, hepatocyte transplantation has been suggested as a safe and potentially effective clinical option for the treatment of acute or decompensating chronic liver failure as well as for hereditary liver disease. Currently, one of the major limiting factors for clinical application is the insufficient access to suitable liver cell preparations. In cooperation with the German and Catalane organ procurement organizations, a routine procedure for the isolation of hepatocytes from donor organs rejected for transplantation (n = 117) has been established. The process is performed ac

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Tanvir, Md Amit Hasan, Md Abdul Khaleque, JunHee Lee, et al. "Three-Dimensional Bioprinting for Intervertebral Disc Regeneration." Journal of Functional Biomaterials 16, no. 3 (2025): 105. https://doi.org/10.3390/jfb16030105.

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The rising demand for organ transplants and the need for precise tissue models have positioned the in vitro biomanufacturing of tissues and organs as a pivotal area in regenerative treatment. Considerable development has been achieved in growing tissue-engineered intervertebral disc (IVD) scaffolds, designed to meet stringent mechanical and biological compatibility criteria. Among the cutting-edge approaches, 3D bioprinting stands out due to its unparalleled capacity to organize biomaterials, bioactive molecules, and living cells with high precision. Despite these advancements, polymer-based s

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Chang, Wenguang, and Jianxun Wang. "Exosomes and Their Noncoding RNA Cargo Are Emerging as New Modulators for Diabetes Mellitus." Cells 8, no. 8 (2019): 853. http://dx.doi.org/10.3390/cells8080853.

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Diabetes belongs to a group of metabolic disorders characterized by long term high blood glucose levels due to either inadequate production of insulin (Type 1 diabetes, T1DM) or poor response of the recipient cell to insulin (Type 2 diabetes, T2DM). Organ dysfunctions are the main causes of morbidity and mortality due to high glucose levels. Understanding the mechanisms of organ crosstalk may help us improve our basic knowledge and find novel strategies to better treat the disease. Exosomes are part of a newly emerged research area and have attracted a great deal of attention for their capacit

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Canadas, Raphaël F., Ziyu Liu, Luca Gasperini, et al. "Numerical and experimental simulation of a dynamic-rotational 3D cell culture for stratified living tissue models." Biofabrication 14, no. 2 (2022): 025022. http://dx.doi.org/10.1088/1758-5090/ac55a2.

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Abstract Human tissues and organs are inherently heterogeneous, and their functionality is determined by the interplay between different cell types, their secondary architecture, and gradients of signalling molecules and metabolites. To mimic the dynamics of native tissues, perfusion bioreactors and microfluidic devices are widely used in tissue engineering (TE) applications for enhancing cell culture viability in the core of 3D constructs. Still, most in vitro screening methods for compound efficacy and toxicity assessment include cell or tissue exposure to constant and homogeneous compound c

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Reznik, O. N., A. E. Skvortsov, and Ya G. Moysyuk. "Preservation and perfusion rehabilitation of donor organs: achievements of the last decade." Almanac of Clinical Medicine 48, no. 3 (2020): 193–206. http://dx.doi.org/10.18786/2072-0505-2020-48-038.

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At present, it is widely recognized that machine perfusion allows for a decreased rate of delayed function of the renal graft and of the risk of liver graft early dysfunction. The aim of the review is to present the actual changes of the donor pool related to prevailing numbers of donors by expanded criteria, to determine the prospects of expanding of the available donor pool based on their selection, as well as development of functional rehabilitation and modification at tissue, cell and molecular levels with the help of perfusion technologies. The article presents the state-of-the art view o

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Glyantsev, S. P., Yu G. Shatunova та A. Werner. "PHENOMENON OF DEMIKHOV. In the Sklifosovsky Institute (1960–1986). Demijоv V.P. Transplante experimental de órganos vitales. Madrid: Editorial Atlante, 1967". Transplantologiya. The Russian Journal of Transplantation 13, № 1 (2021): 74–92. http://dx.doi.org/10.23873/2074-0506-2021-13-1-74-92.

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For the first time, the article introduces into scientific circulation and analyzes the Preface by V.P. Demikhov to his book "Transplantation of vital organs in experiment", published in 1967 in Spanish under the title "Transplante experimental de órganos vitales". Judging by the facts mentioned in the text, V.P. Demikhov wrote it in 1966, reflecting his views on the current state and prospects of homoplastic tissue and organ transplantation. As in previous publications, in particular, in the Preface to the German edition of the book published in Berlin in 1963, V.P. Demikhov substantiated the

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V.I., Kirpatovskiy, Sivkov A.V., Golovanov S.A., et al. "Comparative characteristics of the effectiveness of preventing the progression of CRF using therapy with secretome of embryonic cell and transplantation of neonatal tissues." Experimental and Сlinical Urology 17, no. 1 (2024): 35–46. http://dx.doi.org/10.29188/2222-8543-2024-17-1-35-46.

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Introduction. Literature data and our own research indicate that therapy with immature cell secretion products (secretome) has a pronounced nephroprotective effect both in acute kidney injury and in chronic renal failure (CRF). Considering that the source of the complex of signaling molecules stimulating reparative processes in organs are low-differentiated cells of functionally and anatomically immature organs in a state of deveopment, the question arises to what extent tissue transplantation of these organs reproduces the effect of therapy with a secretome of stem cells in relation to the pr

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Fountain, Matthew Donovan, Laura Ann McLellan, Alexa C. Cannon, and Gilda G. Hillman. "Isoflavones increase radiation-induced apoptosis and modulate pro-inflammatory signaling in EA.hy926 endothelial cells." Journal of Immunology 200, no. 1_Supplement (2018): 170.29. http://dx.doi.org/10.4049/jimmunol.200.supp.170.29.

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Abstract Background The therapeutic use of x-ray ionizing radiation (XIR) for cancer treatment is limited by off target injury to normal tissues resulting in organ-specific toxicities with perpetual inflammation and fibrosis. XIR causes different forms of cell death including apoptosis, necrosis, and mitotic catastrophe that can dictate the resulting inflammatory response. Our lab has shown that soy isoflavones (SIF) reduce XIR-induced inflammation and fibrosis of thoracic organs. We now investigated the effect of SIF and XIR on endothelial cell death in vitro, which could play a role in SIF m

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Cao, N., X. B. Chen, and D. J. Schreyer. "Influence of Calcium Ions on Cell Survival and Proliferation in the Context of an Alginate Hydrogel." ISRN Chemical Engineering 2012 (May 7, 2012): 1–9. http://dx.doi.org/10.5402/2012/516461.

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One goal of biofabrication is to incorporate living cells into artificial scaffolds in order to repair damaged tissues or organs. Although there are many studies on various biofabrication techniques, the maintenance of cell viability during the biofabrication process and cell proliferation after the process is still a challenging issue. Construction of scaffolds using hydrogels composed of natural materials can avoid exposure of cells to harsh chemicals or temperature extremes but can still entail exposure to non-physiological conditions, causing cell damage or even death. This paper presents

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Amantayev, Nurbolat Gabdullaevich, Marina Mikhailovna Silantyeva, and Vadim Tagirovich Khassanov. "Selecting sterilization conditions for the explants of different potato varieties to be in vitro introduced into the culture." Bulletin of the Karaganda University. “Biology, medicine, geography Series” 111, no. 3 (2023): 16–24. http://dx.doi.org/10.31489/2023bmg3/16-24.

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An explant is a fragment of plant tissue or organ that is incubated on its own or used to produce a primary callus. The introduction of any plant’s tissues into the culture in vitro begins with the selection of an uninfected viable explant. The authors presented the results of the effect of various sterilizing agents as well as the treatment timing on the viability of plant explants during microclonal propagation of potatoes of the following varieties: Aladin, Gala, Nevsky, Udacha and Kostanay Novosti. The meristem sprouts from potato tubers were used as parent material. The following commerci

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Russo, Fabrizio, Luca Ambrosio, Marianna Peroglio, et al. "A Hyaluronan and Platelet-Rich Plasma Hydrogel for Mesenchymal Stem Cell Delivery in the Intervertebral Disc: An Organ Culture Study." International Journal of Molecular Sciences 22, no. 6 (2021): 2963. http://dx.doi.org/10.3390/ijms22062963.

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The purpose of the present pilot study was to evaluate the effect of a hydrogel composed of hyaluronic acid (HA) and platelet-rich plasma (PRP) as a carrier for human mesenchymal stem cells (hMSCs) for intervertebral disc (IVD) regeneration using a disc organ culture model. HA was mixed with batroxobin (BTX) and PRP to form a hydrogel encapsulating 1 × 106 or 2 × 106 hMSCs. Bovine IVDs were nucleotomized and filled with hMSCs suspended in ~200 μL of the PRP/HA/BTX hydrogel. IVDs collected at day 0 and nucleotomized IVDs with no hMSCs and/or hydrogel alone were used as controls. hMSCs encapsula

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Smoljak, V. V., and N. V. Slysar. "MORPHOLOGICAL CHANGES OF BONE AND CARTILAGE TISSUE AND BONE MARROW OF NEWBORN CALVES AT DIFFERENT STAGES OF PRENATAL DEVELOPMENT." Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology 26, no. 1 (2025): 188–96. https://doi.org/10.36359/scivp.2025-26-1.23.

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From the very beginning after birth, newborn calves have a different morpho-functional status, which determines their viability in the neonatal period, and is also a prerequisite for various serious diseases, which often end fatally. The skeletal system, as the central organ of immuno-genesis, performs an active function in the metabolism and manifestation of protective functions of calves. That is why its development is evidence of the viability of animals in the future for the entire period of their life. Thus, a sharp decrease in the viability of animals in the neonatal period is due to vio

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Iskra, R., V. Vlizlo, and R. Fedoruk. "Role of chromium (III) in the nutrition of pigs and cattle." Agricultural Science and Practice 3, no. 2 (2016): 56–62. http://dx.doi.org/10.15407/agrisp3.02.056.

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The results of our studies and the data of modern literature regarding the biological role of Cr(III) compounds in conditions of their application in the nutrition for pigs and cattle are discussed. The metabolic impact of Cr(III), coming from different sources – mineral and organic compounds, obtained by chemical synthesis or a nanotechnological method (chromium citrate), as well as in the form of biocomplexes from the cultural medium of Saccharomyces cerevisiae yeasts was analyzed. The metabolic connection between the impact of Cr(III) and the biosynthesis of some hormones – insulin, cortiso

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Chen, Da, Zaohai Zeng, Canye Yu, et al. "Genome-Wide Identification of GH17s Family Genes and Biological Function Analysis of SlA6 in Tomato." Plants 13, no. 17 (2024): 2443. http://dx.doi.org/10.3390/plants13172443.

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Glycoside hydrolases (GHs), enzymes that break down glycosidic bonds in carbohydrates and between carbohydrates and non-carbohydrates, are prevalent in plants, animals, microorganisms, and other organisms. The tomato is a significant crop that contains the GH17 gene family. However, its role in tomatoes has yet to be fully investigated. In this study, we identified 43 GH17 genes from the tomato genome, distributed unevenly across 12 chromosomes. We further analyzed their gene structure, phylogenetic relationships, promoter elements, and expression patterns. The promoter element analysis indica

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Kovalсhuk, I. I., R. S. Fedoruk, M. Ya Spivak, M. M. Romanovyсh та R. Ya Iskra. "Laсtobaсillus сasei IMV B-7280 Immunobiotic Strain Influence on the Viability of Honey Bees and the Content of Microelements in the Organism". Mikrobiolohichnyi Zhurnal 83, № 2 (2021): 42–50. http://dx.doi.org/10.15407/microbiolj83.02.042.

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In modern beekeeping it is important to get safe ecological products, stimulate reproduction and increase the resistance of bees to various diseases as well as to protect them from adverse environmental conditions. Due to this, in recent years there has been a tendency to use biologically active preparations and means of protection of natural origin in beekeeping. They may help to avoid many side effects, because the mechanisms of their biological action are significantly different from synthetic and are based on the physiological activation of the organism’s protective reactions. The aim of t

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Alliston, Spencer P., and Christopher E. Dames. "A needle-form 3-omega sensor for thermal characterization of cryopreserved biological tissues." Journal of Physics: Conference Series 2766, no. 1 (2024): 012190. http://dx.doi.org/10.1088/1742-6596/2766/1/012190.

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Abstract Thermal properties of cryopreserved tissues are critically important to the biopreservation community, which continues to seek more effective ways to store biological samples for improved outcomes in organ transplants as well as to facilitate the preservation of a record of biodiversity. Here, we present a reusable thermal needle-type 3-omega method designed for in situ characterization of such tissues, as well as other soft materials. The 3-omega method is a classic thermal materials characterization technique, which has been integrated into a modified microfabricated neural probe. T

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Ryltseva, Galina A., Alexey E. Dudaev, Natalia G. Menzyanova, et al. "Influence of PHA Substrate Surface Characteristics on the Functional State of Endothelial Cells." Journal of Functional Biomaterials 14, no. 2 (2023): 85. http://dx.doi.org/10.3390/jfb14020085.

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The needs of modern regenerative medicine for biodegradable polymers are wide and varied. Restoration of the viability of the vascular tree is one of the most important components of the preservation of the usefulness of organs and tissues. The creation of vascular implants compatible with blood is an important task of vascular bioengineering. The function of the endothelial layer of the vessel, being largely responsible for the development of thrombotic complications, is of great importance for hemocompatibility. The development of surfaces with specific characteristics of biomaterials that a

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Pashkina, E. A., M. V. Bykova, M. T. Berishvili, Y. M. Zhang, and V. A. Kozlov. "Effect of a supramolecular delivery system based on hyaluronic acid with cyclodextrin on the antitumor properties of oxaliplatin in vitro." Medical Immunology (Russia) 26, no. 5 (2024): 1079–84. http://dx.doi.org/10.15789/1563-0625-eoa-16814.

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One of the modern approaches to the treatment of cancer is the creation of targeted delivery systems for anticancer drugs, which allows increasing the concentration of the delivered substance in the right place and preventing its accumulation in healthy organs and tissues. At the same time, one can also expect an increase in the duration and effectiveness of the drugs, as well as a reduction in side effects during therapy. The hyaluronic acid receptor CD44, which, according to the literature, is highly expressed in many types of tumors and regulates metastasis, is a promising target for target

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Sonina, Anzhella V., Elena N. Terebova, Tamara Yu Dyachkova, Kira V. Morozova, and Nadezhda A. Elkina. "Ecological and biological features of Triglochin maritima L. in the biotopes of the littoral zone with different degree of flooding on the coast of the White Sea." Czech Polar Reports 11, no. 2 (2022): 233–52. http://dx.doi.org/10.5817/cpr2021-2-16.

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The study of Triglochin maritima L. was carried out on the Pomor (western) coast of the White Sea, in the Republic of Karelia (64°22'81"N, 35°93'14"E). Morphological analysis of aboveground and underground parts of the clones was performed on virginal plants. Anatomical analysis of leaf sheaths of the current year shoots, rhizomes and adventitious roots was carried out. The viability of pollen was assessed by determining the relative share of normally developed and malformed pollen grains. The content of heavy metals was determined in the soil, sea water and plant samples. The study was carrie

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Jian, Mariana, Vitalie Cobzac, Victoria Vartic, and Viorel Nacu. "Hepatocytes isolation from adult rats for liver recellularization." Moldovan Medical Journal 62 (1) (March 15, 2019): 13–16. https://doi.org/10.5281/zenodo.2589998.

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<strong>Background:</strong> Currently hepatocytes obtaining is prerequisite to create the necessary conditions for medical research, because it is an important tool in developing of new strategies in tissue engineering domain, which represents obtaining functional organs in laboratory conditions. <strong>Material and methods: </strong>The study was made on adult Wistar rats liver with body weight 274.66± 2.52 g (n=3) which were used for hepatocytes extraction by perfusion through the upper cave vein with combination of type II collagenase and type I dispase and Hank's 0.9 mM MgCl2,

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ZHANG, GEXIANG, HAINA RONG, FERRANTE NERI, and MARIO J. PÉREZ-JIMÉNEZ. "AN OPTIMIZATION SPIKING NEURAL P SYSTEM FOR APPROXIMATELY SOLVING COMBINATORIAL OPTIMIZATION PROBLEMS." International Journal of Neural Systems 24, no. 05 (2014): 1440006. http://dx.doi.org/10.1142/s0129065714400061.

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Membrane systems (also called P systems) refer to the computing models abstracted from the structure and the functioning of the living cell as well as from the cooperation of cells in tissues, organs, and other populations of cells. Spiking neural P systems (SNPS) are a class of distributed and parallel computing models that incorporate the idea of spiking neurons into P systems. To attain the solution of optimization problems, P systems are used to properly organize evolutionary operators of heuristic approaches, which are named as membrane-inspired evolutionary algorithms (MIEAs). This paper

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Wang, Weicang, Karen M. Wagner, Yuxin Wang, et al. "Soluble Epoxide Hydrolase Contributes to Cell Senescence and ER Stress in Aging Mice Colon." International Journal of Molecular Sciences 24, no. 5 (2023): 4570. http://dx.doi.org/10.3390/ijms24054570.

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Aging, which is characterized by enhanced cell senescence and functional decline of tissues, is a major risk factor for many chronic diseases. Accumulating evidence shows that age-related dysfunction in the colon leads to disorders in multiple organs and systemic inflammation. However, the detailed pathological mechanisms and endogenous regulators underlying colon aging are still largely unknown. Here, we report that the expression and activity of the soluble epoxide hydrolase (sEH) enzyme are increased in the colon of aged mice. Importantly, genetic knockout of sEH attenuated the age-related

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Nascimento, Glauce Crivelaro, Rayana Longo Bighetti, Geraldo Aleixo da Silva Passos Júnior, and Karina Fittipaldi Bombonato-Prado. "Human umbilical cord vein as a source of osteoblastic cells." Brazilian Dental Science 17, no. 3 (2014): 31. http://dx.doi.org/10.14295/bds.2014.v17i3.986.

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<p><strong>Objective:</strong> Regenerative medicine and tissue engineering are searching for novel stem cell based therapeutic strategies that will allow for efficient treatment or even potential replacement of damaged organs. The purpose of this work was to study the behaviour of human umbilical cord vein cells (UCVs) through osteoblastic differentiation. <strong>Material and Methods:</strong> Cells were isolated, expanded and cultivated in osteogenic medium. After 7, 14 and 21 days of culture, there were evaluated cell morphology, proliferation, viability and a

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Kowalska, Karolina, Dominika Ewa Habrowska-Górczyńska, Marta Justyna Kozieł, Kinga Anna Urbanek, Kamila Domińska, and Agnieszka Wanda Piastowska-Ciesielska. "Mycotoxin Alternariol (AOH) Affects Viability and Motility of Mammary Breast Epithelial Cells." International Journal of Molecular Sciences 22, no. 2 (2021): 696. http://dx.doi.org/10.3390/ijms22020696.

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Mycotoxins are present in everyday diet as common food and feed pollutants. A part of them is still concerned as so-called emerging mycotoxins. Due to the lack of toxicity data, the safety limits and detail molecular mechanism have been not established yet for all of them. Alternariol (AOH), as one of these mycotoxins, produced by Alternaria species, is so far reported as an estrogenic, genotoxic, and immunomodulatory agent; however, its direct effect on human health is not known. Especially, in the case of hormone-dependent tissues which are sensitive to both endogenic, as well as external es

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Schmelzer, Eva, Vitale Miceli, Cinzia Maria Chinnici, Alessandro Bertani, and Jörg C. Gerlach. "Effects of Mesenchymal Stem Cell Coculture on Human Lung Small Airway Epithelial Cells." BioMed Research International 2020 (March 30, 2020): 1–8. http://dx.doi.org/10.1155/2020/9847579.

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Mesenchymal stem cells (MSCs) and their secreted extracellular vesicles have been used effectively in different lung disease animal models and clinical trials. Their specific beneficial effects, the potential differences between MSCs derived from different organs, and interactions between MSC products and target cells still need to be studied further. Therefore, we investigated the effects of secreted products of human MSCs derived from the bone marrow and adipose tissue on human lung small airway epithelial (AE) cells in vitro. AE cells were cocultured with MSCs in inserts that allowed the fr

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Mohammed, Faten Z., Youstina W. Rizzk, Moustafa S. Abdelhamid, and Ibrahim M. El-Deen. "In Vivo Biological Evaluation of Ethyl 4-(7-hydroxy-4-methyl-2-oxoquinolin-1- ylamino)-coumarin-3-carboxylate as an Antitumor Agent." Anti-Cancer Agents in Medicinal Chemistry 20, no. 18 (2020): 2246–66. http://dx.doi.org/10.2174/1871520620666200728131219.

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Background: Hybridization of coumarin moiety with additional antitumor pharmacophores is an auspicious stratagem to afford precious therapeutic interference for the medication of cancer. Objective: The present study aimed to evaluate the antitumor activity of ethyl 4-(7-hydroxy-4-methyl-2- oxoquinolin-1-ylamino)-coumarin-3-carboxylate against Ehrlich Ascites Carcinoma (EAC) cells in the peritoneal cavity of female mice. Methodology: Molecular docking was used to predict the binding between the test compound and the receptor of breast cancer mutant 3HB5-oxidoreductase, as well as the viability

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MANDELBAUM, MIRA M., EFRAT BARBIRO-MICHAELY, MICHAEL TOLMASOV, and AVRAHAM MAYEVSKY. "EFFECTS OF SEVERE HEMORRHAGE ON IN VIVO BRAIN AND SMALL INTESTINE MITOCHONDRIAL NADH AND MICROCIRCULATORY BLOOD FLOW." Journal of Innovative Optical Health Sciences 01, no. 02 (2008): 177–83. http://dx.doi.org/10.1142/s1793545808000261.

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Severe body stress induced by hypoxemia and hypotension may lead to total body energy state deterioration. The perfusion of the most vital organs is maintained at the expense of "less vital" organs. In the present study, we used a multi-site multi-parametric (MSMP) monitoring system for real-time evaluation of tissue blood flow (TBF) and mitochondrial NADH fluorescence of the brain and the small intestine following hemorrhage. In Group 1, uncontrolled hemorrhage, mean arterial pressure (MAP) was decreased to 40 mmHg within 2 minutes and shed blood was re-infused after 30 minutes. In Group 2, c

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Abdulmaged, Alyaa Idrees, Chin Fhong Soon, Balkis A. Talip, Siti Adibah Ahmad Zamhuri, Salama A. Mostafa, and Wenbin Zhou. "Characterization of Alginate–Gelatin–Cholesteryl Ester Liquid Crystals Bioinks for Extrusion Bioprinting of Tissue Engineering Scaffolds." Polymers 14, no. 5 (2022): 1021. http://dx.doi.org/10.3390/polym14051021.

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Tissue engineering (TE) is an innovative approach to tackling many diseases and body parts that need to be replaced by developing artificial tissues and organs. Bioinks play an important role in the success of various TE applications. A bioink refers to a combination of a living cell, biomaterials, and bioactive molecules deposited in a layer-by-layer form to fabricate tissue-like structures. The research on bioink attempts to offer a 3D complex architecture and control cellular behavior that improve cell physical properties and viability. This research proposed a new multi-material bioink bas

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Bakalova, Rumiana, Dessislava Lazarova, Akira Sumiyoshi, et al. "Redox-Cycling “Mitocans” as Effective New Developments in Anticancer Therapy." International Journal of Molecular Sciences 24, no. 9 (2023): 8435. http://dx.doi.org/10.3390/ijms24098435.

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Our study proposes a pharmacological strategy to target cancerous mitochondria via redox-cycling “mitocans” such as quinone/ascorbate (Q/A) redox-pairs, which makes cancer cells fragile and sensitive without adverse effects on normal cells and tissues. Eleven Q/A redox-pairs were tested on cultured cells and cancer-bearing mice. The following parameters were analyzed: cell proliferation/viability, mitochondrial superoxide, steady-state ATP, tissue redox-state, tumor-associated NADH oxidase (tNOX) expression, tumor growth, and survival. Q/A redox-pairs containing unprenylated quinones exhibited

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Kolberg, Natalia, Nataliya Tikhonova, Sergey Tikhonov, Svetlana Leontieva, and Irina Sergeeva. "Development and effect of poultry lymphoid tissue supplement on cell viability in culture." Food Processing: Techniques and Technology 52, no. 2 (2022): 296–309. http://dx.doi.org/10.21603/2074-9414-2022-2-2364.

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Peptides are biologically active. This quality depends on the technological modes of protein hydrolysis. The research objective was to isolate peptides from the bursa fabricii and evaluate their immunotropic effect on mice of various lines with experimental immunodeficiency and the morphofunctional state of their immunopoiesis organs, i.e., thymus and spleen. The research featured bursa fabricii hydrolysate and peptides, as well as thymus and spleen of male mice. Amine nitrogen was determined according to State Standard R 55479-2013; molecular weight of peptides was determined by gel ele

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Kudva, Abhijith, Frank Luyten, and Jennifer Patterson. "In Vitro Screening of Molecularly Engineered Polyethylene Glycol Hydrogels for Cartilage Tissue Engineering using Periosteum-Derived and ATDC5 Cells." International Journal of Molecular Sciences 19, no. 11 (2018): 3341. http://dx.doi.org/10.3390/ijms19113341.

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The rapidly growing field of tissue engineering and regenerative medicine has brought about an increase in demand for biomaterials that mimic closely the form and function of biological tissues. Therefore, understanding the cellular response to the changes in material composition moves research one step closer to a successful tissue-engineered product. With this in mind, polyethylene glycol (PEG) hydrogels comprised of different concentrations of polymer (2.5%, 4%, 6.5%, or 8% (w/v)); different protease sensitive, peptide cross-linkers (VPMSMRGG or GPQGIWGQ); and the incorporation or lack of a

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Wang, Yilin, Jin Wen, Marwan Almoiliqy, et al. "Sesamin Protects against and Ameliorates Rat Intestinal Ischemia/Reperfusion Injury with Involvement of Activating Nrf2/HO-1/NQO1 Signaling Pathway." Oxidative Medicine and Cellular Longevity 2021 (September 29, 2021): 1–15. http://dx.doi.org/10.1155/2021/5147069.

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Intestinal ischemia-reperfusion (I/R) may induce cell/tissue injuries, leading to multiple organ failure. Based on our preexperiments, we proposed that sesamin could protect against and ameliorate intestinal I/R injuries and related disorders with involvement of activating Nrf2 signaling pathway. This proposal was evaluated using SD intestinal I/R injury rats in vivo and hypoxia/reoxygenation- (H/R-) injured rat small intestinal crypt epithelial cell line (IEC-6 cells) in vitro. Sesamin significantly alleviated I/R-induced intestinal histopathological injuries and significantly reduced serum b

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Marinaro, Federica, Joana M. Silva, Alexandre A. Barros, et al. "A Fibrin Coating Method of Polypropylene Meshes Enables the Adhesion of Menstrual Blood-Derived Mesenchymal Stromal Cells: A New Delivery Strategy for Stem Cell-Based Therapies." International Journal of Molecular Sciences 22, no. 24 (2021): 13385. http://dx.doi.org/10.3390/ijms222413385.

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Polypropylene (PP) mesh is well-known as a gold standard of all prosthetic materials of choice for the reinforcement of soft tissues in case of hernia, organ prolapse, and urinary incontinence. The adverse effects that follow surgical mesh implantation remain an unmet medical challenge. Herein, it is outlined a new approach to allow viability and adhesion of human menstrual blood-derived mesenchymal stromal cells (MenSCs) on PP surgical meshes. A multilayered fibrin coating, based on fibrinogen and thrombin from a commercial fibrin sealant, was optimized to guarantee a homogeneous and stratifi

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