Relevant bibliographies by topics / Vibrissae hair follicle cells

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Academic literature on the topic 'Vibrissae hair follicle cells'

Author: Grafiati
Published: 4 June 2025
Last updated: 23 June 2025

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Journal articles on the topic "Vibrissae hair follicle cells"

1

Tang, Pei, Xueer Wang, Min Zhang, et al. "Activin B Stimulates Mouse Vibrissae Growth and Regulates Cell Proliferation and Cell Cycle Progression of Hair Matrix Cells through ERK Signaling." International Journal of Molecular Sciences 20, no. 4 (2019): 853. http://dx.doi.org/10.3390/ijms20040853.

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Activins and their receptors play important roles in the control of hair follicle morphogenesis, but their role in vibrissae follicle growth remains unclear. To investigate the effect of Activin B on vibrissae follicles, the anagen induction assay and an in vitro vibrissae culture system were constructed. Hematoxylin and eosin staining were performed to determine the hair cycle stages. The 5-ethynyl-2′-deoxyuridine (EdU) and Cell Counting Kit-8 (CCK-8) assays were used to examine the cell proliferation. Flow cytometry was used to detect the cell cycle phase. Inhibitors and Western blot analysis were used to investigate the signaling pathway induced by Activin B. As a result, we found that the vibrissae follicle growth was accelerated by 10 ng/mL Activin B in the anagen induction assay and in an organ culture model. 10 ng/mL Activin B promoted hair matrix cell proliferation in vivo and in vitro. Moreover, Activin B modulates hair matrix cell growth through the ERK–Elk1 signaling pathway, and Activin B accelerates hair matrix cell transition from the G1/G0 phase to the S phase through the ERK–Cyclin D1 signaling pathway. Taken together, these results demonstrated that Activin B may promote mouse vibrissae growth by stimulating hair matrix cell proliferation and cell cycle progression through ERK signaling.
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Trivedi, Mahendra Kumar, and Snehasis Jana. "Assessment of Hair Growth Treatment with the Consciousness Energy Healing Treated Williams Medium E Using Mouse Vibrissae Hair Follicle Organ Culture." JOURNAL OF DERMATOLOGICAL RESEARCH AND THERAPY 1, no. 3 (2019): 12–19. https://doi.org/10.14302/issn.2471-2175.jdrt-18-2520.

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Hair is playing an interesting part in human for social and sexual communication. Loss of hair follicle leads to various skin disorders. For this consequence, the present study has investigated the potential of the Biofield Energy Healing (The Trivedi Effect&reg;) Treated test item (William&rsquo;s Medium E) on the vibrissae hair follicle organ culture cells for the assessment of hair cell growth and development in vitro. The test item was divided into two parts. One part was defined as the untreated test item, where no Biofield Energy Treatment provided, while the other part was defined as the Biofield Energy Treated test item, which received the Biofield Energy Healing Treatment by renowned Biofield Energy Healer, Mahendra Kumar Trivedi. The study parameters like bulb thickness and formation of telogen were assessed using cell-based assay with the help of UTHSCSA Image tool version 3. The experimental results showed that the untreated test item group showed 20.9% and 28.2% increased bulb thickness on day 5 and 7, respectively compared to the day 1, while did not produce telogen follicles upto day 7. Besides, the percentage of telogen follicle was found as 43%, 57%, and 71% on day 3, 5, and 7, respectively of the Biofield Energy Treated test item group compared to the day 1. The overall results demonstrated that the Biofield Energy Treatment has the potential for hair growth promotion as evident via increased the formation of telogen. Therefore, the Biofield Energy Healing (The Trivedi Effect&reg;) Treatment might be useful as a hair growth promoter for various treatment of skin injuries and skin-related disorders like necrotizing fasciitis, actinic keratosis, sebaceous cysts, diaper rash, decubitus ulcer etc. <strong>Source:</strong> https://www.trivedieffect.com/science/assessment-of-hair-growth-treatment-with-the-consciousness-energy-healing-treated-williams-medium-e-using-mouse-vibrissae-hair-follicle-organ-culture/ https://openaccesspub.org/jdrt/article/957
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Reynolds, A. J., and C. A. Jahoda. "Cultured dermal papilla cells induce follicle formation and hair growth by transdifferentiation of an adult epidermis." Development 115, no. 2 (1992): 587–93. http://dx.doi.org/10.1242/dev.115.2.587.

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Adult rat pelage follicle dermal papilla cells induced follicle neogenesis and external hair growth when associated with adult footpad skin epidermis. They thus demonstrated a capacity to completely change the structural arrangement and gene expression of adult epidermis—an ability previously undocumented for cultured adult cells. Isolation chambers ensured that de novo follicle formation must have occurred by eliminating the possibility of cellular contributions, and/or inductive influences, from local skin follicles. These findings argue against previous suggestions of vibrissa follicle specificity, and imply that the potential for hair follicle induction may be common to all adult papilla cells.
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Magnaldo, T., and Y. Barrandon. "CD24 (heat stable antigen, nectadrin), a novel keratinocyte differentiation marker, is preferentially expressed in areas of the hair follicle containing the colony-forming cells." Journal of Cell Science 109, no. 13 (1996): 3035–45. http://dx.doi.org/10.1242/jcs.109.13.3035.

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We have isolated, by subtractive and differential hybridization from a library constructed from keratinocyte colony-forming cells (K-CFCs), a cDNA coding for the rat CD24 (nectadrin, heat stable antigen). CD24, a glycoprotein thought to be involved in cell-cell adhesion and signalling, is highly expressed in keratinocytes located in the bulge area of the rat vibrissa which contains the most K-CFCs. CD24 is also expressed in the outer epithelial sheath of human hair follicles and in glabrous epidermis. However, its expression is not restricted to K-CFCs as demonstrated by cell sorting experiments, and it is thus not a specific marker of clonogenic keratinocytes. Rather, its preferential distribution in keratinocytes located in the most innervated area of the rat vibrissal follicle, i.e., the bulge, suggests that is function could be related to the tactile role of the hair follicle.
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5

Trivedi, Mahendra Kumar, and Snehasis Jana. "Assessment of Hair Growth Treatment with the Consciousness Energy Healing Treated Williams Medium E Using Mouse Vibrissae Hair Follicle Organ Culture." Journal of Dermatologic Research And Therapy 1, no. 3 (2019): 12–19. http://dx.doi.org/10.14302/issn.2471-2175.jdrt-18-2520.

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Hair is playing an interesting part in human for social and sexual communication. Loss of hair follicle leads to various skin disorders. For this consequence, the present study has investigated the potential of the Biofield Energy Healing (The Trivedi Effect®) Treated test item (William’s Medium E) on the vibrissae hair follicle organ culture cells for the assessment of hair cell growth and development in vitro. The test item was divided into two parts. One part was defined as the untreated test item, where no Biofield Energy Treatment provided, while the other part was defined as the Biofield Energy Treated test item, which received the Biofield Energy Healing Treatment by renowned Biofield Energy Healer, Mahendra Kumar Trivedi. The study parameters like bulb thickness and formation of telogen were assessed using cell-based assay with the help of UTHSCSA Image tool version 3. The experimental results showed that the untreated test item group showed 20.9% and 28.2% increased bulb thickness on day 5 and 7, respectively compared to the day 1, while did not produce telogen follicles upto day 7. Besides, the percentage of telogen follicle was found as 43%, 57%, and 71% on day 3, 5, and 7, respectively of the Biofield Energy Treated test item group compared to the day 1. The overall results demonstrated that the Biofield Energy Treatment has the potential for hair growth promotion as evident via increased the formation of telogen. Therefore, the Biofield Energy Healing (The Trivedi Effect®) Treatment might be useful as a hair growth promoter for various treatment of skin injuries and skin-related disorders like necrotizing fasciitis, actinic keratosis, sebaceous cysts, diaper rash, decubitus ulcer etc.
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6

Zhang, Huishan, Shoubing Zhang, Huashan Zhao, et al. "Ovine Hair Follicle Stem Cells Derived from Single Vibrissae Reconstitute Haired Skin." International Journal of Molecular Sciences 16, no. 8 (2015): 17779–97. http://dx.doi.org/10.3390/ijms160817779.

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7

Reynolds, A. J., and C. A. Jahoda. "Hair matrix germinative epidermal cells confer follicle-inducing capabilities on dermal sheath and high passage papilla cells." Development 122, no. 10 (1996): 3085–94. http://dx.doi.org/10.1242/dev.122.10.3085.

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Low passage cultured dermal papilla cells from adult rats stimulate complete hair follicle neogenesis when re-implanted into heterotypic skin. In contrast, cultured sheath cells are non-inductive despite sharing other behavioural characteristics (a common lineage and in situ proximity) with papilla cells. However, since sheath cells can behave inductively in amputated follicles after regenerating the papilla, this poses the question of what influences the sheath to papilla cell transition? During reciprocal tissue interactions specific epidermal cues are crucial to skin appendage development, and while in vivo assays to date have focussed on dermal interactive influence, our aim was to investigate epidermal potential. We have previously observed that hair follicle epidermal cells display exceptional interactive behaviour when combined with follicle dermal cells in vitro. Thus in the present study, hair follicle germinative, outer root sheath or skin basal epidermal cells were separately combined with each of three non-inductive dermal cell types (high passage papilla, low passage sheath or fibroblast) and then implanted into small ear skin wounds. The sheath/germinative and papilla/germinative cell implants repeatedly induced giant vibrissa-type follicles and fibres. In complete contrast, any single cell type and all other forms of recombination were consistently non-inductive. Hence, the adult germinative epidermal cells enable non-inductive adult dermal cells to stimulate hair follicle neogenesis, effectively, by altering their ‘status’, causing the sheath cells to ‘specialise’ and the ‘aged’ papilla cells to ‘rejuvenate’.
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Chernova, O. F., V. F. Kulikov, and A. V. Abramov. "The hair structure of the long-eared gymnure (Otohylomys megalotis)." Proceedings of the Zoological Institute RAS 319, no. 3 (2015): 428–40. http://dx.doi.org/10.31610/trudyzin/2015.319.3.428.

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Weak degree of hair differentiation and microstructure of hair and whiskers of Otohylomys megalotis are similar to those in Hylomys suillus and Neotetracus sinensis: there are spear-shaped lead hairs and zigzag guard hairs of three orders, downy hairs are missing. In O. megalotis: 1) hairs are longer than those of other gymnures; 2) thin convoluted hair bases bound up contributing to the formation of the inert layer of air near the surface of the skin, improves the thermal insulation properties of hair in the absence of downy hairs; 3) strength in thinnest areas of the shaft (at its base and excesses) is provided by thickening of its cuticular scales, the special interconnection between cuticle and cortex, and cruciform layout of medulla discs in these places; 4) the pineal cuticular ornament of hair bases is characteristic of all three species of gymnures and resembles that of other insectivores, as well as of some marsupials and carnivores that reflects similar hair adaptations to the habitats; 5) for the first time discovered specialized pyramidal medulla of vibrissae, stiffening a shaft that is necessary for effective transfer of mechanical impulses to nerve cells of vibrissae follicle and functioning of whiskers as a tactile organ; 6) a long proboscis with well-developed nasal vibrissae and also numerous long whiskers on muzzle, neck, wrists and forearms are important and effective for the O. megalotis orientation in complex terrain karst habitats.
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Yuen, Gary Ka-Wing, Bryan Siu-Yin Ho, Lish Sheng-Ying Lin, Tina Ting-Xia Dong, and Karl Wah-Keung Tsim. "Tectoridin Stimulates the Activity of Human Dermal Papilla Cells and Promotes Hair Shaft Elongation in Mouse Vibrissae Hair Follicle Culture." Molecules 27, no. 2 (2022): 400. http://dx.doi.org/10.3390/molecules27020400.

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To search hair growth-promoting herbal extract, a screening platform of having HEK293T fibroblast being transfected with pTOPFLASH DNA construct was developed over a thousand of herbal extracts and phytochemicals were screened. One of the hits was ethanolic extract of Rhizoma Belamcandae, the rhizome of Belamcanda chinensis (L.) DC. Tectoridin, an isoflavone from Rhizoma Belamcandae, was shown to be responsible for this activation of promoter construct, inducing the transcription of pTOPFLASH in the transfected fibroblasts in a dose-dependent manner. The blockage by DKK-1 suggested the action of tectoridin could be mediated by the Wnt receptor. The hair growth-promoting effects of tectoridin were illustrated in human follicular dermal papilla cells and mouse vibrissae organ cultures. In tectoridin-treated dermal papilla cultures, an activation of Wnt signaling was demonstrated by various indicative markers, including TCF/LEF1 transcriptional activity, nuclear translocation of β-catenin, expressions level of mRNAs encoding axin-related protein, (AXIN2), β-catenin, lymphoid enhancer-binding factor-1 (LEF-1), insulin-like growth factor 1 (IGF-1) and alkaline phosphatase (ALP). In addition, an increase of hair shaft elongation was observed in cultured mouse vibrissae upon the treatment of tectoridin. Tectoridin, as well as the herbal extract of Rhizoma Belamcandae, possesses hair promoting activity, which deserves further development.
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Horne, K. A., and C. A. Jahoda. "Restoration of hair growth by surgical implantation of follicular dermal sheath." Development 116, no. 3 (1992): 563–71. http://dx.doi.org/10.1242/dev.116.3.563.

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The capacity of lower follicle dermal sheath to restore hair growth was tested by removing the lower halves of follicles, and then immediately implanting material containing dermal sheath cells from these bases, into the remaining upper epidermal follicle cavity. Over 60% of recipient follicles produced stout emergent vibrissa fibres and some operations resulted in multiple hair production from a single follicle. Histological examination revealed new dermal papillae within large bulb structures which were sited below the level of amputation--a feature that indicated that the new dermal papilla was derived from implanted material. For many follicles, the failure to produce emergent fibres could be accounted for after histological examination. These results provide clear evidence that lower follicle dermal sheath cells are capable of replacing those of the dermal papilla and it shows that they can do so in the context of the upper follicle. However, because elements of lower follicle epidermis were present in the implant material, the interactive sequence of events cannot be established. Dermal sheath cells have immense potential for papilla cell replacement: questions remain as to whether the distinction between sheath and papilla cells is one of context, or whether the transition requires specific external influences.
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Dissertations / Theses on the topic "Vibrissae hair follicle cells"

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Whitehouse, Claire Jenna. "Hair follicle germinative epidermal cells : a molecular study." Thesis, Durham University, 1999. http://etheses.dur.ac.uk/4292/.

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At the base of the hair follicle epidermal matrix is a population of germinative epidermal (GE) cells that is in close communication with the dermal papilla. These GE cells are at the core of activities that comprise the fundamental processes of cell signalling and differentiation in the hair follicle. Since it is in the germinative region that the signals that produce hair are being received and transcribed, identification of genes expressed in the GE cells will be important for our understanding of hair growth control and the molecular mechanisms operating at the site of epidermal proliferation and differentiation. This study describes the production of a series of cDNA libraries, both by conventional means from rat vibrissa follicles and follicle end bulbs, and by PGR from the GE cells and the tissues of the upper end bulb. These libraries were then used for a variety of screening approaches to isolate cDNA clones, firstly for molecules which are known to be involved in the control of hair growth, and secondly for molecules which are differentially expressed in the follicular germinative epidermis. In order to identify such preferentially expressed genes, a dual labelling differential screen of the vibrissa follicle end bulb cDNA library was performed, using probes derived from the germinative epidermal and upper end bulb PGR generated libraries. Nine putative differentially expressed clones were isolated and sequenced. RNase protection analysis and non radioactive in situ hybridisation was then performed to confirm that these clones were expressed in the germinative epidermis of rat vibrissa follicles. Further characterisation by northern blotting revealed that several of the clones were expressed in multiple tissues. Nucleotide sequence analysis revealed that six of the clones had a concensus BG1 repeat sequence at the end of their 3'UTR. This has been implicated in post-transcriptional control of intracellular mRNA localisation. Three of these clones were related to genes implicated in induction and vesicle trafficking. These clones may therefore be involved in the signal transduction pathways operating in the germinative epidermis in response to primary signalling molecules received from the dermal papilla.
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Sequeira, Inês. "Hair follicle renewal : characteristics of the stem cells." Paris 6, 2010. http://www.theses.fr/2010PA06A697.

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Le follicule pileux se régénère à partir de cellules souches multipotentes situées dans le bulge. Cependant, la multipotentialité de ces cellules souches a été évaluée au niveau de la population entière. Grâce à un système de marquage clonale, nous avons démontré que le pool de cellules souches est hétérogène et contient des précurseurs avec des contributions multipotentes, ainsi que des précurseurs avec des contributions restreintes, ce qui remet en cause le concept de cellule souche multipotente. Ensuite, j’ai décrit la participation de deux groupes distincts de cellules souches au renouvellement du follicule pileux: un groupe contribue uniquement à la gaine épithéliale externe (ORS), caractérisant un lignage restreint; l’autre groupe contribue aux cellules compagnons de l’ORS, aux structures internes et à la matrice du follicule pileux, caractérisant un lignage multipotent. Ces résultats modifient la vision actuelle du comportement des cellules souches et mènent à une re-évaluation de l’organisation cellulaire du follicule pileux. Enfin, j’ai décrit morphologiquement les différents types de follicules pileux de la souris. Pour définir les différences des comportements cellulaires qui mènent à une telle variété, j’ai mis en place une stratégie d’imagerie pour caractériser les divisions cellulaires des cellules souches de la matrice, ainsi qu’un système de culture pour étudier les comportements cellulaires in vivo. Cette étude est basée sur deux stratégies complémentaires (l’analyse clonale rétrospective et l’imagerie 4D). La combinaison de ces approches nous apporte une description des stratégies morphogénétiques sous-tendant le développement du follicule pileux.
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Sleeman, Matthew Alexander. "Hair follicle dermal cells : a morphological, behavioural and molecular study." Thesis, Durham University, 1995. http://etheses.dur.ac.uk/5458/.

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Anatomy and smooth muscle a-actin expression in hair follicles from a variety of animal species (Mink, Polecat, Meerkat, Grey squirrel and stoat) was investigated. Smooth muscle ɑ-actin expression was related to follicle activity. Expression was greatest during anagen, with a marked reduction in expression during telogen. Follicular dermal cells were cultured from the above animal species. In vitro grey squirrel dermal papilla (DP) and dermal sheath (DS) cells both expressed smooth muscle ɑ -actin. Rat dermal papilla cell in vitro aggregative behaviour was characterized, by proliferation, chemotactic and molecular studies. Aggregation behaviour in these cells was not attributed to focal proliferation. However, fluctuations in cell motility correlated with the aggregation process, with the greatest motility between subconfluent and clumped cells. Motility was terminated within the clumped cells. Furthermore, DP cells in vitro secreted molecules that enhancer! motility in subconfluent DP cells and a variety of other cell types. As yet the type and specificity of this medium borne component is unknown. TGFP, bFGF and aFGF were all used as a comparison to the unknown molecule, however migration was rarely similar in magnitude to the response of the DP cell medium. Mouse cDNA probes of BMP 2 and BMP 4 were used to isolate rat homologues from a cDNA library. Wholemount in situ hybridization of BMP 4 expression was consistent with the data in the mouse, however BMP 4 was also expressed in adult rat telogen vibrissae. Molecular expression within in vitro DP cells was studied using a differential screen of a cDNA library. A number of clumped DP specific clones were differentially expressed, one of which having high homology with migration inhibitory factor. These results are discussed, and a hypothetical model is proposed to describe how DP aggregation occurs with reference to dermal condensation in vivo.
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Brown, Alice Clare. "Generating hair follicle inductive dermal papillae cells from adipose derived mesenchymal stem cells." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29596.

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Current management options for cutaneous burn wounds, including split thickness skin grafts and cultured epithelial autografts, generate an epithelial barrier which lacks a dermal layer and skin adnexae including hair follicles and sebaceous glands. This results in a loss of pliability and contractures that cause functional and cosmetic impairment. Embryological hair follicle morphogenesis results from a complex series of mesenchymal-epithelial interactions and to date a method of generating de novo folliculogenesis from human cells has yet to be accomplished. Existing models rely on combining 'inductive’ dermal and 'receptive’ epithelial components and placing them within a suitable model. Epithelial cells are easily obtainable from skin biopsies therefore obtaining sufficient quantities of 'trichogenic’ dermal cells remains the most significant challenge of this approach. The main aim of this project is to contribute to the achievement of de novo folliculogenesis by generating dermal papillae (DP) like-spheroids using adipose derived mesenchymal stem cells (ASCs) that, when combined with responsive epithelial cells, would be capable of inducing hair follicle formation. ASCs were directed towards a hair follicle DP-like fate by culture using the hanging drop method and exposure to Wnt, mimicking signalling and mesenchymal condensation in embryological hair follicle induction. Gene expression analysis using RT-PCR showed that the DP-cell marker Versican is expressed at high levels in ASCs under routine culture conditions and the exposure of ASCs to Wnt results in a more than threefold increase in this expression. These results suggest that Wnt/β-catenin signalling may regulate DP cell aggregative growth through modifying versican expression possibly through binding of β-catenin to the TCF transcription factor complex. Culture of ASCs using the hanging drop method produces spheroids similar in size to human hair follicle DP. Histology of these spheroids demonstrates viable cells that flatten around the outside. The spheroids grow out when replated onto Matrigel in a 3D culture model and exhibit a morphology similar to that of primary hair follicle DP cells. Analysis of mRNA expression demonstrates that Versican expression is significantly upregulated in DP-like spheroids in the absence or presence of Wnt demonstrating that Versican may be responsible for both induction and maintenance of mesenchymal cell condensates. Alpha smooth muscle actin is expressed in low levels in ASC spheroids compared to ASCs in a monolayer and this may reflect a 'migratory’ myofibroblast like phenotype of ASCs in a monolayer similar to cells with the hair follicle dermal sheath. The addition of Wnt to ASC spheroids has no additional effect on Versican expression possibly reflecting a negative feedback loop resulting from high local concentrations of endogenous Wnt expression from ASCs. The results of this study show that spheroid cell culture and exposure to Wnt of ASCs results in cell clusters with similar morphology and gene expression to hair follicle DP cells. The novel method of DP-like cell generation described in this study makes use of cells that are readily obtainable from patients and require minimal time and manipulation in culture and therefore could potentially be rapidly translatable to clinical trials.
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Voisin, Benjamin. "Impact of the hair follicle cycle on Langerhans cell homeostasis." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ118.

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Le follicule pileux (FP) est un appendice cutané animé par un cycle régénératif dynamique provoquant des modifications de son microenvironnement. Les cellules de Langerhans (CLs), sentinelles de l’épiderme, sont en partie localisées à proximité du FP. Cette association spatiale nous a conduit à explorer le possible impact du cycle pileux sur l’homéostasie des CLs. Durant mon doctorat, nous avons mis en évidence (1) une augmentation de la prolifération des CLs au cours de l’anagène (phase de pousse du poil), (2) le mécanisme moléculaire sous-jacent impliquant une variation d’expression folliculaire de l’IL-34, une cytokine cruciale dans l’homéostasie des CLs et (3) un départ accru des CLs vers les ganglions lymphatiques en catagène (phase de régression du FP) concomitant avec le recrutement de cellules susceptibles d’être des précurseurs des CLs.Par ailleurs, la structure de la peau ainsi que la densité et le type de FP peuvent varier selon la région corporelle considérée. Nous avons émis l’hypothèse de variations locales dans la composition du système immunitaire cutané. Notre étude, focalisée sur les cellules dendritiques cutanées, a démontré l’existence d’une hétérogénéité de ces cellules en fonction de la zone de peau considérée<br>The hair follicle (HF) is a skin appendage endowed with a dynamic regenerating cycle. This renewal remodels the HF microenvironment. Langerhans cells (LCs) are epidermal immune sentinels, a part of which localizes close to the HF. This spatial association led us to explore whether the HF cycle could impact on LC homeostasis. During my doctorate, we uncovered an anagen (HF growing phase)-associated burst of LC proliferation with dividing cells associated with the HF. Using mouse models of HF loss and hair cycle manipulation, we showed that HFs are dispensable for initial formation of the LC network but critical for the proliferation burst. We correlated it to a cyclic variation of IL-34 expression, a crucial cytokine for LC homeostasis, by a specific subset of HF cells. In addition, catagen (HF regression phase) is characterized by the departure of LCs to draining lymph nodes and the concomitant recruitment of a potential LC precursor.The skin structure as well as the density and type of HFs vary across body areas. This observation led us to assess the possibility of local variations in skin immune cells composition. Our study, focused on cutaneous dendritic cells, highlighted an heterogeneity in those cells according to the skin area considered
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Souza, Dener Madeiro de. "Análise de marcadores de células tronco e progenitores das células de polpa dentária e de vibrissas de camundongos C57BL6." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-18012017-102541/.

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Os tecidos da polpa dentária e vibrissa são dois microambientes celulares que compartilham a mesma origem embrionária. Ambos possuem o seu nicho especifico pós-natal que abrigam células tronco adultas (CTA). O objetivo do trabalho foi investigar a expressão diferencial dos marcadores de células pluripotentes, mesenquimais e neuroepiteliais nas populações de células tronco isoladas das vibrissas (CTV) e polpa de dente (CTPD) de camundongos C57BL-6. Resultados obtidos no presente trabalho, utilizando o método de imunofluorescência, revelaram que as CTA de ambos tecidos expressam um amplo painel de marcadores de pluripotência (Oct4, Nanog e Sox2), mesenquimais (CD73, CD90 e CD105), hematopoiético (CD34), crista neural (CKit), neuronal (Nestina) e epitelial (Integrina &#945;6, LGR5 e LGR6) e indica possível potencial destas células em diversas linhagens celulares. Desta forma, células isoladas destes tecidos podem ser interessantes para serem aplicadas em diversos tratamentos na medicina regenerativa. Portanto, o estudo comparativo da expressão de um amplo painel de marcadores de células tronco em CTV e CTPD pode vir a aumentar o leque de possibilidades de sua utilização na terapia celular. Com isso, as células isoladas de polpa dentária foram submetidas à análise de expressão de marcadores já citados e a outros conhecidamente positivos e específicos para os folículos piloso como Citoqueratina 15 (CK15), LRig1 e Blimp1. Foram realizados ensaios de imunofluorescência, imunohistoquímica, citometria de fluxo e RT-PCR. Os dados obtidos nos permitiram concluir, que as CTA isoladas das ambas as fontes são bastante semelhantes em relação ao seu imunofenótipo, porém as características da sua diferenciação precisam ainda ser analisadas.<br>The tissues of the dental pulp and vibrissae are two cellular microenvironments that share the same embryonic origin. Both have their postnatal specific niche that keep adult stem cells (ASC). The objective of this study was to investigate the differential expression of pluripotent markers, mesenchymal and neuroepithelial in populations of stem cells isolated from whiskers (WSC) and dental pulp (DPSC) C57BL-6 mice. Results obtained in this study, using immunofluorescence, revealed that the ASC both tissues express a broad panel of pluripotency markers (Oct4, Nanog and Sox2), mesenchymal cells (CD73, CD90 and CD105), hematopoietic (CD34), crest neural (cKIT), neuronal (Nestin) and epithelial (Integrin &#945;6, LGR5 and LGR6) and indicates possible potential of these cells in several cell lines. Thus, isolated cells of these tissues may be interesting for application in various treatments in regenerative medicine. Therefore, the comparative study of the expression of a broad panel of stem cell markers in WSC and DPSC could increase the range of possibilities for their use in cell therapy. Thus, the isolated cells were subjected to the dental pulp marker expression analysis cited above and others known to be positive and specific to hair follicles as Cytokeratin 15 (CK15), and LRig1 Blimp1. Immunofluorescence assays were performed, immunohistochemistry, flow cytometry and RT-PCR. The data allowed us to conclude that the ASC isolated from both sources are quite similar with respect to their immunophenotype, but the characteristics of differentiation remain to be analyzed.
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TRUONG, NGUYEN TRUONG AN. "PRE-CLINICAL STUDIES OF ADULT HUMAN SKIN- AND HAIR FOLLICLE-DERIVED NEURAL PRECURSOR CELLS." Thesis, University of Sydney, 2021. https://hdl.handle.net/2123/24409.

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Dementia is a pressing global health challenge and new treatments to halt, delay or reverse cognitive impairment are of major interest. Memory dysfunction is closely associated with neuronal and synaptic loss, particularly in the hippocampus which is affected at the earliest stages of Alzheimer’s dementia. Neurorestoration with stem cell therapy is a promising treatment strategy, aimed at replenishing depleted neuronal pools and reinstating synaptic connections. Previously, our group discovered the isolation and culture of neural precursors derived from canine skin, termed skin-derived neural precursors (SKNs). These cells have the potential to circumvent major limitations of current stem cell therapies. This thesis endeavours to translate existing canine SKN technology to adult human skin tissue. First, the canine SKN protocol was applied to mature human hip skin, however viable neuronally-restricted SKN cultures could not be produced. Further investigation found significantly greater SKN yield from adult human scalp skin compared to hip skin, consistent with the idea that hair follicle is the primary niche of precursor cells in the skin. Also, hair follicles from the head generated significantly more precursor neurospheres than skin tissue from the head or hip. The next study detailed development of a practical protocol for isolating and expanding neural precursors from adult human hair follicles, termed hair follicle-derived neural precursors (HFNs). The new workflow includes CTS™ reagents and development of processes that are compatible with Good Manufacturing Practice. A novel chemotaxis assay was performed to better understand chemotactic migration, important for future medical applications. The study found dose- and time- dependent responses to trophic factors BDNF and VEGF, the former dependent on the high affinity TrkB receptor. Conversely, there was no directed migration towards gradients of GDNF. Finally, HFN survival, in vivo behaviour, and host response following transplantation in the aged rat hippocampus was investigated. In contrast to expectations, donor cells could not be identified within the hippocampus at 28-day post-injection, and in both sham and cell-transplanted brains, microglia aggregation associated with hypo-ramification was significant near the injection site. These results suggest potential microglia activation associated with the transplantation procedures. Such an activated immunological environment could negatively impacted donor cell survival. Altogether, this thesis provides novel knowledge about a method of producing neural precursors from human hair follicles in the skin, some of their critical cell attributes and important pre-clinical data relevant to future human trials.
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Buscone, Serena. "Unravelling novel molecular targets for photobiomodulation in human hair follicle towards the development of more effective light-based therapies for hair growth." Thesis, University of Bradford, 2017. http://hdl.handle.net/10454/16001.

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Light and optical techniques have made a profound impact on modern medicine both in diagnostics and in therapy. Therapeutic action of light is based on photomechanical, photothermal, photochemical and photobiological interactions, depending on the wavelength, power density, exposure time and optical properties of tissue and cells. Last decade experienced a growing rise of commercial devices for management of hair growth, where all of them are based on low levels of light resulting into photobiological, non-thermal interaction of photons with cells, a process that recently has received an official term ‘photobiomodulation’. However, the design and analysis of the reported clinical studies are highly debated in a wider scientific community. The picture is further complicated by a virtual lack of proof about the exact molecular targets that mediate the physiological response of skin and hair follicles (HF) to low levels of light. The goal of this project was to investigate the expression of light-sensitive receptors in the human HF and to study the impact of UV-free blue light on hair growth ex vivo. The expression of Cryptochromes 1 and 2 (CRY1, 2), Opsin 2 and 3 (OPN2 and OPN3), but not other Opsins 1, 4 and 5 was detected in the distinct compartments of skin and anagen HF. Evaluation of the physiological role of detected light-sensitive receptors on hair growth was performed by the modulation of photoreceptors activity in HF ex vivo model. HFs treated with KL001, a stabilizer of CRY1 protein that lengthens the circadian period, delayed HF anagen-catagen transition; while silencing of CRY1 induced premature catagen development accompanied by reduced cell proliferation. Silencing of CRY1 in the HF outer root sheath (ORS) cells in vitro caused downregulation of ii genes involved in the control of proliferation; including the cyclin dependent kinase 6 (CDK6). OPN3 also had a positive effect on metabolic activity and proliferation of the ORS cells in vitro. OPN3 silencing resulted in the altered expression of genes involved in the control of proliferation and apoptosis. Investigated CRY1, OPN2 and 3 greatly absorb in the blue to green-region of the visible spectrum. This led us to investigate the effect of blue light on HF growth. Daily treatment with blue light (453 nm, 3.2 J/cm2, 16 nm full width half maximum) prolonged anagen phase in HF ex vivo that was associated with sustained proliferation. In addition, blue light (3.2 J/cm2) significantly stimulated proliferation of ORS cells in vitro. This effect was abrogated by silencing of OPN3. To summarize, CRY 1, OPN 2 and OPN 3 are expressed in the distinct compartments of the HF, including HF stem cells. Blue light (453 nm) at low radiant exposure exerts a positive effect on hair growth ex vivo, potentially via interaction with OPN3. The further research should be conducted to decipher interactions between blue light and the investigated receptors in the HFs. In addition, the beneficial effect of blue light at low radiant exposure on hair growth raises a possibility of increasing therapeutic efficacy when combined with topical chemistry used for management of hair growth.
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Wilson, Caroline Lesley. "The hair follicle : studies of the outer root sheath in health and disease, and a possible role for the bulge." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309741.

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Drake, Summer Elizabeth. "Sensory hairs in the bowhead whale (Cetacea, Mammalia)." Kent State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=kent1406300822.

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Books on the topic "Vibrissae hair follicle cells"

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Hoffman, Robert M., ed. Multipotent Stem Cells of the Hair Follicle. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3786-8.

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Wang, Etienne Cho Ee. Hair Growth Is Induced by Blockade of Macrophage-derived Oncostatin M and Downstream Jak-stat5 Signaling in Hair Follicle Stem Cells. [publisher not identified], 2018.

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Hoffman, Robert M. Multipotent Stem Cells of the Hair Follicle: Methods and Protocols. Springer New York, 2016.

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Hoffman, Robert M. Multipotent Stem Cells of the Hair Follicle: Methods and Protocols. Springer New York, 2018.

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Book chapters on the topic "Vibrissae hair follicle cells"

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Legué, Emilie, Inês Sequeira, and Jean-François Nicolas. "Hair Follicle Stem Cells." In Stem Cells and Cancer Stem Cells,Volume 3. Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-94-007-2415-0_5.

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Pasolli, Hilda Amalia. "Hair Follicle Stem Cells." In Cell and Molecular Biology and Imaging of Stem Cells. John Wiley & Sons, Inc, 2014. http://dx.doi.org/10.1002/9781118285602.ch9.

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Schaart, F. M., A. Mayer-da-Silva, and C. E. Orfanos. "Cultivation of Human Hair Follicle Cells." In Hair and Hair Diseases. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-74612-3_13.

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Lin, Sung-Jan, Wen-Yen Huang, Chih-Chiang Chen, Mingxing Lei, and Jin-Bon Hong. "Hair Follicle Stem Cells and Hair Regeneration." In Cell Engineering and Regeneration. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-08831-0_12.

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Lin, Sung-Jan, Wen-Yen Huang, Chih-Chiang Chen, Mingxing Lei, and Jin-Bon Hong. "Hair Follicle Stem Cells and Hair Regeneration." In Cell Engineering and Regeneration. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-37076-7_12-1.

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Hoffman, Robert M. "Hair Follicle Pluripotent Stem (hfPS) Cells." In Human Adult Stem Cells. Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-90-481-2269-1_8.

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Konstantinos, Anastasakis. "Hair Follicle Cloning and Stem Cells." In Updates in Clinical Dermatology. Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-74314-6_11.

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Wang, Xiaoyang, Yizhan Xing, and Yuhong Li. "Identification and Characterization of Hair Follicle Stem Cells." In Somatic Stem Cells. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8697-2_5.

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Anastassakis, Konstantinos. "Stem Cells and Hair Follicle Cloning/Engineering." In Androgenetic Alopecia From A to Z. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-10613-2_40.

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Yoshida, Yuzo, Ryoji Tsuboi, and Jiro Kishimoto. "Dermal Sheath Cells and Hair Follicle Regeneration." In Stem Cell Biology and Regenerative Medicine. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-98331-4_5.

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Conference papers on the topic "Vibrissae hair follicle cells"

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Khidhir, Karzan. "Β-CATENIN AND PROSTACYCLIN RECEPTOR DIFFERENTIALLY REGULATE HAIR FOLLICLE DERMAL PAPILLA CELLS". У International Conference of Natural Science 2017. College of Basic Education, Charmo University, Chamchamal, Sulaimani/Iraq, 2018. http://dx.doi.org/10.31530/17021.

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Wang, Chengming, Lanchi Xie, Xiaojing Xu, et al. "Preliminary analysis of facial hair follicle distribution for forensic identification using OCT." In Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVI, edited by Daniel L. Farkas, Dan V. Nicolau, and Robert C. Leif. SPIE, 2018. http://dx.doi.org/10.1117/12.2285309.

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Lau, Katherine, Christian Matthaeus, Jurgen Popp, et al. "Label-Free Non-Destructive Identification of Stem Cells in the Hair Follicle with Confocal Raman Spectrocopy." In XXII INTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY. AIP, 2010. http://dx.doi.org/10.1063/1.3482558.

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Popov, Boris V. "LGR5 expressing cells of hair follicle as potential targets for antibody mediated anti-cancer laser therapy." In Saratov Fall Meeting and Workshop on Laser Physics and Photonics 2012, edited by Valery V. Tuchin, Elina A. Genina, Vladimir L. Derbov, and Igor V. Meglinski. SPIE, 2013. http://dx.doi.org/10.1117/12.2018463.

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Jampa-ngern, S., K. Viravaidya-Pasuwat, S. Suvanasuthi, and A. Khantachawana. "Effect of laser diode light irradiation on growth capability of human hair follicle dermal papilla cells." In 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2017. http://dx.doi.org/10.1109/embc.2017.8037634.

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Kim, Sun Hye, Everardo Macías, Christopher Sistrunk, and Marcelo L. Rodriguez-Puebla. "Abstract 3889: Cyclin-dependent kinase 4 levels affect the number of hair follicle stem cells in mouse epidermis." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-3889.

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7

Huang, Xiyong, Michael D. Protheroe, Ahmed M. Al-Jumaily, and Sharad P. Paul. "The Significance of Hair Thermal Diffusivity on Melanoma Incidence." In ASME 2017 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/imece2017-71693.

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There is an increased risk of melanoma in adulthood when a child (pre-puberty) has been exposed to high levels of ultraviolet radiation (UVR). It has also been hypothesized that the childhood body air (vellus hair) plays a role in the increased incidence of melanoma later in life. This is attributed to the fact that the vellus hair has properties and physiology which encourage the transmission of harmful energy into the follicle of the hair and ultimately cause damage to the stem cells in residence there. Later in life these damaged stem cells become involved in the generation of melanomas in the epidermis. It has been debated whether the UVR or the heat generated by it is the main contributor to melanoma occurrence. This research is the first step in investigating this phenomenon by focusing on the contribution of changes in thermal characteristics on the incidence of melanoma. To test the hypothesis that child hair can transmit energy more easily than adult hair the transient electro-thermal technique is used to determine the thermal diffusivity of the hair. This involved subjecting platinum coated hair samples to a current pulse and measuring the subsequent voltage response in the sample. Results show that the child hair has a thermal diffusivity around two times higher than adult hair, thus supporting the hypothesis. Further research will be needed, in particular, quantifying the optical transmission characteristics of child hair compared to adult hair.
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Rho, Okkyung, Kaoru Kiguchi, and John DiGiovanni. "Abstract 2559: Targeting mTORC1 may provide selectivity for inhibiting proliferation of hair follicle stem/progenitor cells during tumor promotion." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-2559.

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Park, Heuijoon, Sonali Lad, Kelsey Boland, et al. "Abstract LB-039: Chronic inflammation-mediated contribution of bone marrow-derived epithelial cells and hair follicle stem cells to development of cutaneous neoplasms." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-lb-039.

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Park, Heuijoon, Sonali Lad, Kelsey Boland, et al. "Abstract LB-039: Chronic inflammation-mediated contribution of bone marrow-derived epithelial cells and hair follicle stem cells to development of cutaneous neoplasms." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-lb-039.

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