Journal articles on the topic 'Viehbock, F. P. (Franz P.)'

Correction for ‘Robert Willis and Franz Reuleaux: pioneers in the theory of machines’ by F. C. Moon (Notes Rec. R. Soc. Lond. 57 , 209–230. (doi: 10.1098/rsnr.2003.0207 )). p. 228. The legend to figure 11 should read as follows: Figure 11. Sketch by Willis of the front claw of a common crab. From R. Willis, Principles of mechanism, 2nd edn (London 1870).

Background. In recent years musicologists revealed an increasing interest in the problem of historical typology of F. Schubert’s composer style. In fact, scholars question possibility to characterize it as romantic, in their turn suggesting another interpretations and characteristics. For instance, M. Brown avoids usage of the term “Romantic” referring to F. Schubert, insisting on him being a part of a Classical tradition. In order to substantiate his viewpoint, the scholar appeals to harmony of the composer, where novelties, according to M. Brown, are not in fact innovations but incredibly skilful incarnation of Classical ideas. More moderate opinion on the discussed problem is stated by Ch. Rosen (2003). While acknowledging “revolutionary” nature of F. Schubert’s harmony, the scholar simultaneously points out a “special status” of the composer in musical art, a status not allowing to apply neither Classical, nor Romantic standards to the works of master. Consequently, as Ch. Rosen says, F. Schubert ended up being “in-between” Classical tradition and Romantic innovations. In his earlier study (1997) abovementioned author uses term “Postclassicism” referring to F. Schubert and other artists of his generation. A collision “F. Schubert – L. van Beethoven” is regarded both by Е.Badura-Skoda (2004) and J. Daverio (2002). The latter one tries to solve it while regarding it through prism of R. Schumann’s observation on this problem. Thus, it is obvious that reception of F. Schubert’s style as typologically ambiguous has a long-lasting history dating back to Romantic era. This intrigue can be found in researches of XX century as well. For example, phenomenon of style of F. Schubert’s chamber works has become a topic of P. Wolfius’ rumination, who defined it as “intermediate” (1974). Mentioned above works of the last third of XX century and beginning of XXI century prove relevance of the problem of historical typology of F. Schubert’s composer style for modern musicology. This calls for its further development through analytical studying of musical material while using historically-typological method of research. In the given aspect, special attention should be drawn to early works by composer, including four Violin sonatas. Objectives. The goal of this paper is to comprehend stylistic phenomenon of these works as a result of mixture of Classical experience gained by F. Schubert and first signs of his oncoming individual view on the essence of music and sound. Methods. In order to achieve this goal, the author of current work uses a periodization of F. Schubert’s chamber legacy, created by H. Gleason and W. Becker (1988) as well as models of “biography scenario”, revealed by N. Savytska (2010). According to the former one, Violin sonatas, written in 1816–1817, don’t belong to the “mature” works; at the same time according to the latter ones, due to F. Schubert’s style evolution being smooth and gradual its starting and finishing points have no radical discrepancies, that would be caused by the change of orientation of composer’s creative method, and as a result, in the early works one can discern some key features of the mature ones. It is relevant, among others, for the sonata genre, where composers first achievements, incidentally, were made in its violin type, preceding highly individual accomplishments of piano sonatas. This situation in the given article is explained as a result of a composer becoming more and more mature as a musician through his life, undoubtedly influenced by special features of this process. Results and discussion. Given that F. Schubert’s Violin sonatas are named differently by performers, publishers and scholars (op. 137 consists of three Sonatas or Sonatinas, op. 162 is also known as “Duo”), it was necessary to conduct a research basing on various sources (Holl, 1973; Vetter, 1953; Deutsch, 1978), in order to ensure righteousness of definition of all the pieces regarded as “sonata”. On the foreground of observation on F. Schubert’s understanding of the cycle it was possible to reveal composer’s loyalty to rules of his time. Sonata ор. 137 № 1 is composed as a classical three-movement model; subsequent ones, including op. 162, embody four-movement model, and that can be a reason to draw parallels between F. Schubert and L. van Beethoven. Individual steps of the journey of author’s self-identification as a composer are traced. Sonata ор. 137 № 1 is marked by frequent employment of variative development in the principal theme of the first movement, that causes its turning into digressive episode; inclusion of contrasting episode in the middle sections of Andante in Sonatas ор. 137 № 2–3 (that is not prescribed by chosen musical form) foreshadows tonal device, favoured by F. Schubert in his mature works – preference to Subdominant sphere over Dominant in four-movement cycle with tonal and dramaturgical highlighting of pair “lyricism – game” in middle movements (slow ones and Minuets); binarity of tonal centres in expositions and even recapitulations of sonata form being substituted by ternarity, that causes a whole section to be a principal unit of structure etc. Sonata op. 162 acquires significance of climax in F. Schubert’s ascent to self-identity in sonata genre. Its expanded structure, including gigantic development of the Finale, Minuet being substituted by Scherzo, parts of performers being completely equal in every respect allow to regard this work as first “Grand Sonata” in F. Schubert’s legacy. Moreover – experience gained by composer while creating it will be applied in cyclic composition for piano in mature period of creativity. Conclusions. In Conclusions analytical observations are summarized and generalized as well as levels of artistic structure of Violin sonatas, incarnating specifics of F. Schubert’s understanding of music as a composer of his historical time, are revealed.

Background:Gender differences in prevalence and disease course are known in various rheumatic diseases; however, investigations of gender difference concerning therapeutical response have yielded variable results.Objectives:The aim of this retrospective study was to investigate, whether a gender difference in response rate to biological disease-modifying antirheumatic drugs (bDMARDs) and apremilast in bDMARD-naïve patients could be observed across the three most prevalent inflammatory arthritis diseases: rheumatoid arthritis (RA), spondylarthritis (SpA) and psoriatic arthritis (PsA). Additionally, a response to individual TNF blockers was investigated in this respect.Methods:Data from bDMARD-naïve RA-, SpA- and PsA-patients from Bioreg, the Austrian registry for biological DMARDs in rheumatic diseases, were used. Patients with a baseline (Visit 1=V1) and follow-up visits at 6 months (Visit 2=V2) and 12 months (Visit 3=V3) were included and response to therapy with TNF-inhibitors (TNFi), furthermore to therapy with rituximab, tocilizumab and apremilast was analyzed according to gender. The remaining bDMARDs were not analyzed due to small numbers. Key response-parameter for RA was disease activity score (DAS28), whereas for PsoA the Stockerau Activity Score for Psoriatic Arthritis (SASPA) and for SpA the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) were employed; in addition, the Health assessment Questionnaire (HAQ) was used. Data were analyzed in R Statistic stratified by gender using Kruskal-Wallis and Wilcoxon tests.Results:354 women and 123 men with RA (n=477), 81 women and 69 men with PsA (n=150), 121 women and 191 men with SpA (n=312) were included. No significant differences in biometrics was seen between female and male patients at baseline in all diseases.In RA patients overall DAS28 decreased from baseline (V1) to V2 and V3 (DAS28: V1: male: 4.38 [3.66, 5.11], female: 4.30 [3.68, 5.03], p(m/f) = 0.905; V2: male: 2.66 [1.73, 3.63], female: 3.10 [2.17, 3.98], p(m/f) = 0.015; V3: male: 2.25 [1.39, 3.36], female: 3.01 [1.87, 3.87], p(m/f) = 0.002). For TNF inhibitors (n=311), there was a significant difference between genders at V2 (Fig.1a). Patients receiving Rituximab (n=41) displayed a significantly higher DAS28 at baseline in females, which diminished in the follow up: V1: (p(m/f) p=0.002; V2: p=0.019; V3: p=0.13); response to tocilizumab (n=63) did not show any gender differences.In PsA patients overall SASPA decreased from baseline (V1) to V2 and V3 (SASPA: V1: male: 4.00 [2.80, 5.20], female: 4.40 [2.80, 5.80], p(m/f) = 0.399; V2: male: 2.20 [1.20, 3.50], female: 3.40 [2.00, 5.00], p(m/f) = 0.071; V3: male: 1.80 [0.80, 2.70], female: 3.01 [2.35, 4.80], p(m/f) = 0.001). For TNF inhibitors (n=79), there was a significant difference between genders at V3 (Fig 1a). For Apremilast (n=39), there was a significant difference between genders at V2 (Fig.1c).In SpA patients overall BASDAI decreased from baseline (V1) to V2 and V3 (BASDAI: V1: male: 4.70 [2.88, 6.18], female: 4.80 [3.30, 6.20], p(m/f) = 0.463; V2: male: 3.05 [2.00, 4.60], female: 3.64 [2.62, 5.41], p(m/f) = 0.039; V3: male: 3.02 [1.67, 4.20], female: 3.65 [2.18, 5.47], p(m/f) = 0.016). In V3 a differential BASDAI in response to TNFi (n=299) was observed (Fig.1a).Possible differences of response to individual TNFi (etanercept, infliximab, other TNFi) measured by HAQ were investigated in all diseases together. The difference between male and females was significant at baseline for all 3 TNFi; whereas with the use of ETA the significant difference was carried through to V2 and V3, it was lost with the use of IFX and was variable with the other TNFi (Fig.1b)Figure 1.Conclusion:Female patients showed a statistically lower response to TNFi in all three disease entities (RA, SpA and PsoA) to a variable degree in our homogenous central european population. Interestingly, the difference was not uniform across individual TNFi when measured by HAQ. Gender differences were also seen in response to Apremilast.Disclosure of Interests:Elisabeth Loibner: None declared, Valentin Ritschl: None declared, Burkhard Leeb Speakers bureau: AbbVie, Roche, MSD, Pfizer, Actiopharm, Boehringer-Ingelheim, Kwizda, Celgene, Sandoz, Grünenthal, Eli-Lilly, Grant/research support from: TRB, Roche, Consultancies: AbbVie, Amgen, Roche, MSD, Pfizer, Celgene, Grünenthal, Kwizda, Eli-Lilly, Novartis, Sandoz;, Peter Spellitz: None declared, Gabriela Eichbauer-Sturm: None declared, Jochen Zwerina: None declared, Manfred Herold: None declared, Miriam Stetter: None declared, Rudolf Puchner Speakers bureau: AbbVie, BMS, Janssen, Kwizda, MSD, Pfizer, Celgene, Grünenthal, Eli-Lilly, Consultant of: AbbVie, Amgen, Pfizer, Celgene, Grünenthal, Eli-Lilly, Franz Singer: None declared, Ruth Fritsch-Stork: None declared

Michael Lappert was one of the giants of twentieth-century organometallic chemistry. His research, carried out over six decades and leading to about 800 publications, had a profound and influential effect on the field, and his contributions covered almost every block of the Periodic Table. His early reputation was established by his extensive studies in boron chemistry exemplified by the reports of BCl 4 − , BN cyclobutadiene analogues, triborylamines, BCl 3 -catalysed ortho -Claisen rearrangements and evidence for restricted rotation about the B–N bond in aminoboranes. He had a lifelong interest in amides, including those of carbon, and especially electron-rich olefins, which remarkably were the ready source of numerous transition-metal carbene complexes. The last could also be obtained directly from the Vilsmeier reagent. He was the first to show that a carbene complex may act as an initiator of olefin metathesis. Later interests concerned the syntheses of new types of compound from all blocks of the Periodic Table driven by his imaginative use of new types of ligand (either sterically crowded or having no β-hydrogen atoms, often including SiMe 3 or Bu t substituents to confer lipophilicity). The use of CH n SiMe (3− n ) ( n = 0, 1 or 2) to stabilize transition-metal alkyl compounds was a major advance, because at the time stable homoleptic (a term he introduced) transition-metal alkyl compounds were unknown. He showed that the −CH(SiMe 3 ) 2 ligand could stabilize both low-coordinate transition metal and lanthanide compounds. Similarly, carbene analogues of the Main Group 14 elements germanium, tin and lead were obtained. Surprisingly in the solid state, these species were weakly dimerized (for example R 2 Sn=SnR 2 ), and unexpectedly exhibited a pyramidalized geometry at the heavy element. The latter had very significant bonding implications, because it differed fundamentally from the well-known planar structure of the corresponding alkenes. The first persistent or stable paramagnetic heavier Main Group element species MR 2 (M = P or As) and MR 3 (M = Ge or Sn) were also obtained while parallel work using −N(SiMe 3 ) 2 resulted in the corresponding Main Group amido derivatives. Other lipophilic ligands, such as β-diketiminates, were also widely used, as were bulky aryloxo and thiolato ligands, to obtain stable low-coordinate Main Group species. The first examples of d- and f-block species containing bridging alkyl groups were described. Those who worked with him cited his vast knowledge and supportive low-key advisory style, which ensured a contented and productive laboratory atmosphere. In addition to his scientific work, he was deeply interested in opera, literature and the theatre, about which he could talk knowledgeably.

A list of Curculionoidea (Nemonychidae, Anthribidae, Rhynchitidae, Attelabidae, Brentidae, Apionidae, Nanophyidae, Brachyceridae, Curculionidae, Erirhinidae, Raymondionymidae, Dryoph-thoridae, Scolytidae, Platypodidae) thus far known from Italy is drawn up, updating that by Abbazzi et al. published in 1995. Distributional data of each species are given for broad regions such as northern, central, southern Italy, Sicily and Sardinia. New synonymies are: Acentrotypus laevigatus (Kirby, 1808) (= A. brunnipes (Boheman, 1839), syn.nov.), Ceutorhynchus talickyi Korotyaev, 1980 (= C. strejceki Dieckmann, 1981, syn. nov.), Ceutorhynchus pallipes Crotch,1866 (= Curculio minutus Reich, 1797 not Drury, [1773], syn. nov.; = Curculio contractus Marsham, 1802 not Fourcroy, 1785, syn. nov.), Dodecastichus consentaneus (Boheman, 1843) (= D. c. latialis (Solari & Solari, 1915), syn. nov.; = D. c. dimorphus (Solari & Solari, 1915), syn. nov.; = D. c. pentricus Di Marco & Osella, 2001, syn. nov.), Dodecastichus dalmatinus (Gyllenhal, 1843) (= D. d. lauri (Stierlin, 1861), syn. nov.), Dodecastichus mastix (Olivier, 1807) (= D. m. perlongus (Solari & Solari, 1915), syn. nov.; = D. m. scabrior (Reitter, 1913), syn. nov.), Dorytomus Germar, 1817 (= D. subgen. Chaetodorytomus Iablokov-Khnzorian, 1970, syn. nov.; = D. subgen. Euolamus Reitter, 1916, syn. nov.; = D. subgen. Olamus Reitter, 1916, syn. nov.), Exapion Bedel, 1887 (= Ulapion Ehret, 1997, syn. nov.), Larinus ursus (Fabricius, 1792) (= L. carinirostris Gyllenhal, 1837, syn. nov.; = L. genei Boheman, 1843, syn. nov.), Lixini Schönherr, 1823 (= Rhinocyllini Lacordaire, 1863, syn. nov.), Metacinops rhinomacer Kraatz, 1862 (= M. calabrus Stierlin, 1892, syn. nov.), Microplontus nigrovittatus (Schultze,1901) (= Ceutorhynchus subfasciatus Chevrolat, 1860 not Schönherr, 1826, syn. nov.), Otiorhynchus amicalis cenomanus Colonnelli & Magnano, nom. nov. (= O. a. lessinicus (Osella, 1983) not O. lessinicus Franz, 1938, syn. nov.), Otiorhynchus anophthalmoides omeros nom. nov. (= O. a. istriensis (F. Solari, 1955) not Germar, 1824, syn. nov.), Otiorhynchus anthracinus (Scopoli, 1763) (= O. calabrus Stierlin, 1880, syn. nov.), Otiorhynchus armadillo (Rossi, 1792) (= O. halbherri Stierlin, 1890, syn. nov.), Otiorhynchus clibbianus Colonnelli & Magnano, nom. nov. (= O. judicariensis (Osella, 1983) not Reitter, 1913, syn. nov.), Otiorhynchus cornicinus Stierlin, 1861 (= Curculio laevigatus Fabricius, 1792 not Paykull, 1792, syn. nov.), Otiorhynchus fortis Rosenhauer, 1847 (= O. fortis valarsae Reitter, 1913, syn. nov.), Otiorhynchus nodosus (O. F. Müller, 1764) (= O. nodosus comosellus Boheman, 1843, syn. nov.; = O. nodosus gobanzi Gredler, 1868, syn. nov.), Otiorhynchus pupillatus Gyllenhal, 1834 (= O. p. angustipennis Stierlin, 1883, syn. nov.; = O. venetus F. Solari, 1947, syn. nov.), Otiorhynchus serradae Colonnelli & Magnano, nom. nov. (= O. carinatus (Osella 1983) not (Paykull, 1792), syn. nov.), Otiorhynchus strigirostris Boheman, 1843 (= O. aterrimus : Di Marco & Osella, 2002 not Boheman, 1843, syn. nov.; = O. calvus Fiori, 1899, syn. nov.), O. sulcatus (Fabricius, 1775) (= O. linearis Stierlin, 1861, syn. nov.), Otiorhynchus tenebricosus (Herbst, 1784) (= O. olivieri Abbazzi & Osella, 1992, syn. nov.), Phrydiuchus augusti Colonnelli, nom. nov. (= Ceuthorrhynchus speiseri Schultze, 1897 not C. speiseri Frivaldszkyi, 1894, syn. nov.), Phyllobius maculicornis Germar, 1824 (= P. m. lucanus Solari & Solari, 1903, syn. nov.), Phyllobius pyri (Linné, 1758) (= P. vespertinus (Fabricius, 1792), syn. nov.), Polydrusus subgen. Chaerodrys Jacquelin du Val, [1854] (= P. subgen. Metadrosus Schilsky, 1910, syn. nov.), Polydrusus subgen. Eudipnus C. G. Thomson, 1859 (= P. subgen. Chrysoyphis Gozis, 1882, syn. nov.; P. subgen. Thomsoneonymus Desbrochers, 1902, syn. nov.), Polydrusus subgen. Eurodrusus Korotyaev & Meleshko, 1997 (= P. subgen. Neoeustolus Alonso-Zarazaga & Lyal, 1999, syn. nov.), Polydrusus armipes Brullé, 1832 (= P. a. faillae Desbrochers, 1859, syn. nov.), Pseudomyllocerus invreae invreae (F. Solari, 1948) (= Curculio cinerascens Fabricius, 1792 not [Gmelin], 1790], syn. nov. ), Zacladus Reitter, 1916 (= Z. subgen. Amurocladus Korotyaev, 1997, syn. nov.; = Z. subgen. Angarocladus Korotyaev, 1997, syn. nov.; = Z. subgen. Gobicladus Korotyaev, 1997, syn. nov.; = Z. subgen. Scythocladus Korotyaev, 1997, syn. nov.). New placements are: Amalini Wagner, 1936 as a tribe from synonymy under Ceutorhynchini; Acentrotypus Alonso-Zarazaga, 1990, Aizobius Alonso-Zarazaga, 1990, Aspidapion Schilsky, 1901, Catapion Schilsky, 1906, Ceratapion Schilsky, 1901, Cistapion Wagner, 1924,Cyanapion Bokor, 1923, Diplapion Reitter, 1916, Eutrichapion Reitter, 1916, Exapion Bedel, 1887, Helianthemapion Wagner, 1930, Hemitrichapion Voss, 1959, Holotrichapion Györffy, 1956, Ischnopterapion Bokor, 1923, Ixapion Roudier & Tempère,1973, Kalcapion Schilsky, 1906, Lepidapion Schilsky, 1906, Melanapion Wagner, 1930, Mesotrichapion Györffy, 1956, Metapion Schilsky, 1906, Omphalapion Schilsky, 1901, Onychapion Schilsky, 1901, Oryxolaemus AlonsoZarazaga, 1990, Osellaeus Alonso-Zarazaga, 1990, Perapion Wagner, 1907, Phrissotrichum Schilsky, 1901, Pirapion Reitter, 1916, Protapion Schilsky, 1908, Pseudapion Schilsky, Pseudoperapion Wagner, 1930, Pseudoprotapion Ehret, 1990, Pseudostenapion Wagner, 1930, Rhodapion AlonsoZarazaga, 1990, Squamapion Bokor, 1923, Stenopterapion Bokor, 1923, Synapion Schilsky, 1902, Taeniapion Schilsky, 1906, Trichopterapion Wagner, 1930, all as genera from subgenera of Apion Herbst, 1797; Aspidapion subgen. Koestlinia Alonso-Zarazaga, 1990 and Phryssotrichum subgen. Schilskyapion Alonso-Zarazaga, 1990 from synonymy with Apion Herbst, 1797; Phyllobius italicus Solari & Solari, 1903 and Phyllobius reicheidius Desbrochers, 1873, both from subspecies of P. pyri (Linné, 1758); Mogulones aubei (Boheman, 1845) as a valid species from synonymy with M. talbum (Gyllenhal, 1837); Styphlidius italicus Osella, 1981 as species from subspecies of S. corcyreus (Reitter, 1884). Otiorhynchus subgen. Presolanus Pesarini, 2001 is here selected over O. subgen. Pesolanus Pesarini, 2001, alternative original spelling, here rejected. The incorrect original spelling Otiorhynchus nocturnus peetzi Franz, 1938 is emended in O. n. peezi. New combination are: Eremiarhinus (Depresseremiarhinus) dilatatus (Fabricius, 1801), comb. nov.; Eremiarinus (Pseudorhinus) impressicollis (Boheman, 1834) jarrigei (Roudier, 1959); E. (Pseudorhinus) impressicollis luciae (Ragusa, 1883), comb. nov.; E. (Pseudorhinus) impressicollis peninsularis (F. Solari, 1940), comb. nov.; E. (Pseudorhinus) laesirostris (Fairmaire, 1859), comb. nov., all resulting from the new placement of Depresseremiarhinus Pic, 1914 and of Pseudorhinus Melichar, 1923 as subgenera of Eremiarhinus Fairmaire, 1876. The subfamilial name Phytonominae Gistel, 1848 is used as valid over Hyperinae Marseul, 1863. Nomenclatural changes published from 1992 to date, and affecting Italian weevils are also listed.

Background:Coll2-1 is a peptide of 9 amino acid located in the triple helix of type II collagen molecule reflecting cartilage degradation (1). Coll2-1NO2 is the nitrated form of Coll2-1 and considered as a biomarker of the inflammatory-related cartilage degradation (2). This peptide is involved in osteoarthritis physiopathology since it was demonstrated that Coll2-1 induced synovitis in rat.Objectives:To identify if biochemical markers s-Coll2-1 and s-Coll2-1NO2 are associated to knee osteoarthritis (OA), focusing on pain, function as well as structural features assessed by MRI in various knee compartments and to assess their ability at predicting knee OA worsening.Methods:116 subjects with knee OA were followed during one year with pain, function and MRI evaluation (PRODIGE study,NCT02070224). Type II collagen-specific biomarker Coll2-1 and its nitrated form Coll2-1NO2 were directly measured in serum using immunoassays at baseline and after three, six and twelve months follow-up.Results:sColl2-1 and sColl2-1NO2 were associated to several baseline knee features quantified with Whole-Organ Magnetic Resonance Imaging Score (WORMS). S-Coll2-1 was significantly correlated with bursitis (r=0.29, P<0.01), bone attrition (r=0.25, P=0.01), cysts (r=0.24, P=0.02) and cartilage (r=0.23, P=0.03) WORMS sub-scores for the whole joint as well as with the medial femorotibial joint sum score (r=0.26, P=0.01) and medial femorotibial joint cartilage (r=0.23, P=0.02). s-Coll2-1NO2 was correlated with WORMS total score (r=0.23, P=0.02), WORMS scores in the patellofemoral (r=0.23, P=0.02) and medial femorotibial compartments (r=0.21, P=0.03) and with osteophytes scores (r=0.27, P<0.01). Baseline s-Coll2-1NO2 was higher in subjects with a pain worsening (426.4 pg/mL [278.04-566.95]) as compared to non-progressors (306.84 [200.37-427.84]) over one year (AUC=0.655, P=0.015).Conclusion:Cartilage biomarkers s-Coll2-1 and s-Coll2-1NO2 are associated to several knee OA features quantified with WORMS scoring system on MRI. Serum values of Coll2-1NO2 are also associated to a worsening of target knee pain over one year. Coll2-1 and Coll2-1NO2, in association with other structural features, pain and function, could help at identifying OA phenotypes and patients at risk of OA worsening.References:[1]Mobasheri A, Lambert C, Henrotin Y. Coll2-1 and Coll2-1NO2 as exemplars of collagen extracellular matrix turnover - biomarkers to facilitate the treatment of osteoarthritis? Expert Rev Mol Diagn. 2019 Sep;19(9):803-812. doi: 10.1080/14737159.2019.1646641. Epub 2019 Sep 4.[2]Lambert C, Borderie D, Dubuc JE, Rannou F, Henrotin Y. Type II collagen peptide Coll2-1 is an actor of synovitis. Osteoarthritis Cartilage. 2019 Nov;27(11):1680-1691. doi: 10.1016/j.joca.2019.07.009. Epub 2019 Jul 17.Acknowledgments:PRODIGE study (NCT02070224) was performed in the framework of a convention between the Walloon region and ARTIALIS SA. (convention n°6905).Disclosure of Interests:Yves Henrotin Grant/research support from: HEEL, TILMAN, Berenice Costes Employee of: Artialis SA, Michel Malaise: None declared, Damien Loeuille: None declared, Thierry Conrozier Consultant of: LABRHA, SANOFI, MEDAC, Yves Maugars: None declared, Franz Pelousse Shareholder of: Sodiray, Jean-Marc Lemaire Shareholder of: Sodiray, Thibault Helleputte Shareholder of: DNAlytics, Cedric Tits Employee of: DNAlytics, Elisabeth Cobraiville Employee of: Artialis SA, Sebastien Pirson Employee of: Artialis, Laetitia Garcia Employee of: Artialis, Alain Labasse Employee of: Artialis SA, Anne-Christine Hick Employee of: Artialis SA

The random first order transition theory (RFOT) describing the transition from a supercooled liquid to an ideal glass has been actively developed over the last twenty years. This theory is formulated in a way that allows a description of the transition from the initial equilibrium state to the final metastable state without considering any kinetic processes. The RFOT and its applications for real molecular systems (multicomponent liquids with various intermolecular potentials, gel systems, etc.) are widely represented in English-language sources. However, these studies are practically not described in any Russian sources. This paper presents an overview of the studies carried out in this field. REFERENCES 1. Sanditov D. S., Ojovan M. I. Relaxation aspectsof the liquid—glass transition. Uspekhi FizicheskihNauk. 2019;189(2): 113–133. DOI: https://doi.org/10.3367/ufnr.2018.04.0383192. Tsydypov Sh. B., Parfenov A. N., Sanditov D. S.,Agrafonov Yu. V., Nesterov A. S. Application of themolecular dynamics method and the excited statemodel to the investigation of the glass transition inargon. Available at: http://www.isc.nw.ru/Rus/GPCJ/Content/2006/tsydypov_32_1.pdf (In Russ.). GlassPhysics and Chemistry. 2006;32(1): 83–88. DOI: https://doi.org/10.1134/S10876596060101113. Berthier L., Witten T. A. Glass transition of densefluids of hard and compressible spheres. PhysicalReview E. 2009;80(2): 021502. DOI: https://doi.org/10.1103/PhysRevE.80.0215024. Sarkisov G. N. Molecular distribution functionsof stable, metastable and amorphous classical models.Uspekhi Fizicheskih Nauk. 2002;172(6): 647–669. DOI:https://doi.org/10.3367/ufnr.0172.200206b.06475. Hoover W. G., Ross M., Johnson K. W., HendersonD., Barker J. A., Brown, B. C. Soft-sphere equationof state. The Journal of Chemical Physics, 1970;52(10):4931–4941. DOI: https://doi.org/10.1063/1.16727286. Cape J. N., Woodcock L. V. Glass transition in asoft-sphere model. The Journal of Chemical Physics,1980;72(2): 976–985. DOI: https://doi.org/10.1063/1.4392177. Franz S., Mezard M., Parisi G., Peliti L. Theresponse of glassy systems to random perturbations:A bridge between equilibrium and off-equilibrium.Journal of Statistical Physics. 1999;97(3–4): 459–488.DOI: https://doi.org/10.1023/A:10046029063328. Marc Mezard and Giorgio Parisi. Thermodynamicsof glasses: a first principles computation. J. of Phys.:Condens. Matter. 1999;11: A157–A165.9. Berthier L., Jacquin H., Zamponi F. Microscopictheory of the jamming transition of harmonic spheres.Physical Review E, 2011;84(5): 051103. DOI: https://doi.org/10.1103/PhysRevE.84.05110310. Berthier L., Biroli, G., Charbonneau P.,Corwin E. I., Franz S., Zamponi F. Gardner physics inamorphous solids and beyond. The Journal of ChemicalPhysics. 2019;151(1): 010901. DOI: https://doi.org/10.1063/1.5097175 11. Berthier L., Ozawa M., Scalliet C. Configurationalentropy of glass-forming liquids. The Journal ofChemical Physics. 2019;150(16): 160902. DOI: https://doi.org/10.1063/1.509196112. Bomont J. M., Pastore G. An alternative schemeto find glass state solutions using integral equationtheory for the pair structure. Molecular Physics.2015;113(17–18): 2770–2775. DOI: https://doi.org/10.1080/00268976.2015.103832513. Bomont J. M., Hansen J. P., Pastore G.Hypernetted-chain investigation of the random firstordertransition of a Lennard-Jones liquid to an idealglass. Physical Review E. 2015;92(4): 042316. DOI:https://doi.org/10.1103/PhysRevE.92.04231614. Bomont J. M., Pastore G., Hansen J. P.Coexistence of low and high overlap phases in asupercooled liquid: An integral equation investigation.The Journal of Chemical Physics. 2017;146(11): 114504.DOI: https://doi.org/10.1063/1.497849915. Bomont J. M., Hansen J. P., Pastore G. Revisitingthe replica theory of the liquid to ideal glass transition.The Journal of Chemical Physics. 2019;150(15): 154504.DOI: https://doi.org/10.1063/1.508881116. Cammarota C., Seoane B. First-principlescomputation of random-pinning glass transition, glasscooperative length scales, and numerical comparisons.Physical Review B. 2016;94(18): 180201. DOI: https://doi.org/10.1103/PhysRevB.94.18020117. Charbonneau P., Ikeda A., Parisi G., Zamponi F.Glass transition and random close packing above threedimensions. Physical Review Letters. 2011;107(18):185702. DOI: https://doi.org/10.1103/PhysRevLett.107.18570218. Ikeda A., Miyazaki K. Mode-coupling theory asa mean-field description of the glass transition.Physical Review Letters. 2010;104(25): 255704. DOI:https://doi.org/10.1103/PhysRevLett.104.25570419. McCowan D. Numerical study of long-timedynamics and ergodic-nonergodic transitions in densesimple fluids. Physical Review E. 2015;92(2): 022107.DOI: https://doi.org/10.1103/PhysRevE.92.02210720. Ohtsu H., Bennett T. D., Kojima T., Keen D. A.,Niwa Y., Kawano M. Amorphous–amorphous transitionin a porous coordination polymer. ChemicalCommunications. 2017;53(52): 7060–7063. DOI:https://doi.org/10.1039/C7CC03333H21. Schmid B., Schilling R. Glass transition of hardspheres in high dimensions. Physical Review E.2010;81(4): 041502. DOI: https://doi.org/10.1103/PhysRevE.81.04150222. Parisi G., Slanina, F. Toy model for the meanfieldtheory of hard-sphere liquids. Physical Review E.2000;62(5): 6554. DOI: https://doi.org/10.1103/Phys-RevE.62.655423. Parisi G., Zamponi F. The ideal glass transitionof hard spheres. The Journal of Chemical Physics.2005;123(14): 144501. DOI: https://doi.org/10.1063/1.204150724. Parisi G., Zamponi F. Amorphous packings ofhard spheres for large space dimension. Journal ofStatistical Mechanics: Theory and Experiment. 2006;03:P03017. DOI: https://doi.org/10.1088/1742-5468/2006/03/P0301725. Parisi G., Procaccia I., Shor C., Zylberg J. Effectiveforces in thermal amorphous solids with genericinteractions. Physical Review E. 2019;99(1): 011001. DOI:https://doi.org/10.1103/PhysRevE.99.01100126. Stevenson J. D., Wolynes P. G. Thermodynamic −kinetic correlations in supercooled liquids: a criticalsurvey of experimental data and predictions of therandom first-order transition theory of glasses. TheJournal of Physical Chemistry B. 2005;109(31): 15093–15097. DOI: https://doi.org/10.1021/jp052279h27. Xia X., Wolynes P. G. Fragilities of liquidspredicted from the random first order transition theoryof glasses. Proceedings of the National Academy ofSciences. 2000;97(7): 2990–2994. DOI: https://doi.org/10.1073/pnas.97.7.299028. Kobryn A. E., Gusarov S., Kovalenko A. A closurerelation to molecular theory of solvation formacromolecules. Journal of Physics: Condensed Matter.2016; 28 (40): 404003. DOI: https://doi.org/10.1088/0953-8984/28/40/40400329. Coluzzi B. , Parisi G. , Verrocchio P.Thermodynamical liquid-glass transition in a Lennard-Jones binary mixture. Physical Review Letters.2000;84(2): 306. DOI: https://doi.org/10.1103/PhysRevLett.84.30630. Sciortino F., Tartaglia P. Extension of thefluctuation-dissipation theorem to the physical agingof a model glass-forming liquid. Physical Review Letters.2001;86(1): 107. DOI: https://doi.org/10.1103/Phys-RevLett.86.10731. Sciortino, F. One liquid, two glasses. NatureMaterials. 2002;1(3): 145–146. DOI: https://doi.org/10.1038/nmat75232. Farr R. S., Groot R. D. Close packing density ofpolydisperse hard spheres. The Journal of ChemicalPhysics. 2009;131(24): 244104. DOI: https://doi.org/10.1063/1.327679933. Barrat J. L., Biben T., Bocquet, L. From Paris toLyon, and from simple to complex liquids: a view onJean-Pierre Hansen’s contribution. Molecular Physics.2015;113(17-18): 2378–2382. DOI: https://doi.org/10.1080/00268976.2015.103184334. Gaspard J. P. Structure of Melt and Liquid Alloys.In Handbook of Crystal Growth. Elsevier; 2015. 580 p.DOI: https://doi.org/10.1016/B978-0-444-56369-9.00009-535. Heyes D. M., Sigurgeirsson H. The Newtonianviscosity of concentrated stabilized dispersions:comparisons with the hard sphere fluid. Journal ofRheology. 2004;48(1): 223–248. DOI: https://doi.org/10.1122/1.163498636. Ninarello A., Berthier L., Coslovich D. Structureand dynamics of coupled viscous liquids. MolecularPhysics. 2015;113(17-18): 2707–2715. DOI: https://doi.org/10.1080/00268976.2015.103908937. Russel W. B., Wagner N. J., Mewis J. Divergencein the low shear viscosity for Brownian hard-spheredispersions: at random close packing or the glasstransition? Journal of Rheology. 2013;57(6): 1555–1567.DOI: https://doi.org/10.1122/1.482051538. Schaefer T. Fluid dynamics and viscosity instrongly correlated fluids. Annual Review of Nuclearand Particle Science. 2014;64: 125–148. DOI: https://doi.org/10.1146/annurev-nucl-102313-02543939. Matsuoka H. A macroscopic model thatconnects the molar excess entropy of a supercooledliquid near its glass transition temperature to itsviscosity. The Journal of Chemical Physics. 2012;137(20):204506. DOI: https://doi.org/10.1063/1.476734840. de Melo Marques F. A., Angelini R., Zaccarelli E.,Farago B., Ruta B., Ruocco, G., Ruzicka B. Structuraland microscopic relaxations in a colloidal glass. SoftMatter. 2015;11(3): 466–471. DOI: https://doi.org/10.1039/C4SM02010C41. Deutschländer S., Dillmann P., Maret G., KeimP. Kibble–Zurek mechanism in colloidal monolayers.Proceedings of the National Academy of Sciences.2015;112(22): 6925–6930. DOI: https://doi.org/10.1073/pnas.150076311242. Chang J., Lenhoff A. M., Sandler S. I.Determination of fluid–solid transitions in modelprotein solutions using the histogram reweightingmethod and expanded ensemble simulations. TheJournal of Chemical Physics. 2004;120(6): 3003–3014.DOI: https://doi.org/10.1063/1.163837743. Gurikov P., Smirnova I. Amorphization of drugsby adsorptive precipitation from supercriticalsolutions: a review. The Journal of Supercritical Fluids.2018;132: 105–125. DOI: https://doi.org/10.1016/j.supflu.2017.03.00544. Baghel S., Cathcart H., O’Reilly N. J. Polymericamorphoussolid dispersions: areviewofamorphization, crystallization, stabilization, solidstatecharacterization, and aqueous solubilization ofbiopharmaceutical classification system class II drugs.Journal of Pharmaceutical Sciences. 2016;105(9):2527–2544. DOI: https://doi.org/10.1016/j.xphs.2015.10.00845. Kalyuzhnyi Y. V., Hlushak S. P. Phase coexistencein polydisperse multi-Yukawa hard-sphere fluid: hightemperature approximation. The Journal of ChemicalPhysics. 2006;125(3): 034501. DOI: https://doi.org/10.1063/1.221241946. Mondal C., Sengupta S. Polymorphism,thermodynamic anomalies, and network formation inan atomistic model with two internal states. PhysicalReview E. 2011;84(5): 051503. DOI: https://doi.org/10.1103/PhysRevE.84.05150347. Bonn D., Denn M. M., Berthier L., Divoux T.,Manneville S. Yield stress materials in soft condensedmatter. Reviews of Modern Physics. 2017;89(3): 035005.DOI: https://doi.org/10.1103/RevModPhys.89.03500548. Tanaka H. Two-order-parameter model of theliquid–glass transition. I. Relation between glasstransition and crystallization. Journal of Non-Crystalline Solids. 2005;351(43-45): 3371–3384. DOI:https://doi.org/10.1016/j.jnoncrysol.2005.09.00849. Balesku R. Ravnovesnaya i neravnovesnayastatisticheskaya mekhanika [Equilibrium and nonequilibriumstatistical mechanics]. Moscow: Mir Publ.;1978. vol. 1. 404 c. (In Russ.)50. Chari S., Inguva R., Murthy K. P. N. A newtruncation scheme for BBGKY hierarchy: conservationof energy and time reversibility. arXiv preprintarXiv: 1608. 02338. DOI: https://arxiv.org/abs/1608.0233851. Gallagher I., Saint-Raymond L., Texier B. FromNewton to Boltzmann: hard spheres and short-rangepotentials. European Mathematical Society.arXiv:1208.5753. DOI: https://arxiv.org/abs/1208.575352. Rudzinski J. F., Noid W. G. A generalized-Yvon-Born-Green method for coarse-grained modeling. TheEuropean Physical Journal Special Topics. 224(12),2193–2216. DOI: https://doi.org/10.1140/epjst/e2015-02408-953. Franz B., Taylor-King J. P., Yates C., Erban R.Hard-sphere interactions in velocity-jump models.Physical Review E. 2016;94(1): 012129. DOI: https://doi.org/10.1103/PhysRevE.94.01212954. Gerasimenko V., Gapyak I. Low-Densityasymptotic behavior of observables of hard spherefluids. Advances in Mathematical Physics. 2018:6252919. DOI: https://doi.org/10.1155/2018/625291955. Lue L. Collision statistics, thermodynamics,and transport coefficients of hard hyperspheres inthree, four, and five dimensions. The Journal ofChemical Physics. 2005;122(4): 044513. DOI: https://doi.org/10.1063/1.183449856. Cigala G., Costa D., Bomont J. M., Caccamo C.Aggregate formation in a model fluid with microscopicpiecewise-continuous competing interactions.Molecular Physics. 2015;113(17–18): 2583–2592.DOI: https://doi.org/10.1080/00268976.2015.107800657. Jadrich R., Schweizer K. S. Equilibrium theoryof the hard sphere fluid and glasses in the metastableregime up to jamming. I. Thermodynamics. The Journalof Chemical Physics. 2013;139(5): 054501. DOI: https://doi.org/10.1063/1.481627558. Mondal A., Premkumar L., Das S. P. Dependenceof the configurational entropy on amorphousstructures of a hard-sphere fluid. Physical Review E.2017;96(1): 012124. DOI: https://doi.org/10.1103/PhysRevE.96.01212459. Sasai M. Energy landscape picture ofsupercooled liquids: application of a generalizedrandom energy model. The Journal of Chemical Physics.2003;118(23): 10651–10662. DOI: https://doi.org/10.1063/1.157478160. Sastry S. Liquid limits: Glass transition andliquid-gas spinodal boundaries of metastable liquids.Physical Review Letters. 2000;85(3): 590. DOI: https://doi.org/10.1103/PhysRevLett.85.59061. Uche O. U., Stillinger F. H., Torquato S. On therealizability of pair correlation functions. Physica A:Statistical Mechanics and its Applications. 2006;360(1):21–36. DOI: https://doi.org/10.1016/j.physa.2005.03.05862. Bi D., Henkes S., Daniels K. E., Chakraborty B.The statistical physics of athermal materials. Annu.Rev. Condens. Matter Phys. 2015;6(1): 63–83. DOI:https://doi.org/10.1146/annurev-conmatphys-031214-01433663. Bishop M., Masters A., Vlasov A. Y. Higher virialcoefficients of four and five dimensional hardhyperspheres. The Journal of Chemical Physics.2004;121(14): 6884–6886. DOI: https://doi.org/10.1063/1.177757464. Sliusarenko O. Y., Chechkin A. V., SlyusarenkoY. V. The Bogolyubov-Born-Green-Kirkwood-Yvon hierarchy and Fokker-Planck equation for manybodydissipative randomly driven systems. Journal ofMathematical Physics. 2015;56(4): 043302. DOI:https://doi.org/10.1063/1.491861265. Tang Y. A new grand canonical ensemblemethod to calculate first-order phase transitions. TheJournal of chemical physics. 2011;134(22): 224508. DOI:https://doi.org/10.1063/1.359904866. Tsednee T., Luchko T. Closure for the Ornstein-Zernike equation with pressure and free energyconsistency. Physical Review E. 2019;99(3): 032130.DOI: https://doi.org/10.1103/PhysRevE.99.03213067. Maimbourg T., Kurchan J., Zamponi, F. Solutionof the dynamics of liquids in the large-dimensionallimit. Physical review letters. 2016;116(1): 015902. DOI:https://doi.org/10.1103/PhysRevLett.116.01590268. Mari, R., & Kurchan, J. Dynamical transition ofglasses: from exact to approximate. The Journal ofChemical Physics. 2011;135(12): 124504. DOI: https://doi.org/10.1063/1.362680269. Frisch H. L., Percus J. K. High dimensionalityas an organizing device for classical fluids. PhysicalReview E. 1999;60(3): 2942. DOI: https://doi.org/10.1103/PhysRevE.60.294270. Finken R., Schmidt M., Löwen H. Freezingtransition of hard hyperspheres. Physical Review E.2001;65(1): 016108. DOI: https://doi.org/10.1103/PhysRevE.65.01610871. Torquato S., Uche O. U., Stillinger F. H. Randomsequential addition of hard spheres in high Euclideandimensions. Physical Review E. 2006;74(6): 061308.DOI: https://doi.org/10.1103/PhysRevE.74.06130872. Martynov G. A. Fundamental theory of liquids;method of distribution functions. Bristol: Adam Hilger;1992, 470 p.73. Vompe A. G., Martynov G. A. The self-consistentstatistical theory of condensation. The Journal ofChemical Physics. 1997;106(14): 6095–6101. DOI:https://doi.org/10.1063/1.47327274. Krokston K. Fizika zhidkogo sostoyaniya.Statisticheskoe vvedenie [Physics of the liquid state.Statistical introduction]. Moscow: Mir Publ.; 1978.400 p. (In Russ.)75. Rogers F. J., Young D. A. New, thermodynamicallyconsistent, integral equation for simple fluids. PhysicalReview A. 1984;30(2): 999. DOI: https://doi.org/10.1103/PhysRevA.30.99976. Wertheim M. S. Exact solution of the Percus–Yevick integral equation for hard spheres Phys. Rev.Letters. 1963;10(8): 321–323. DOI: https://doi.org/10.1103/PhysRevLett.10.32177. Tikhonov D. A., Kiselyov O. E., Martynov G. A.,Sarkisov G. N. Singlet integral equation in thestatistical theory of surface phenomena in liquids. J.of Mol. Liquids. 1999;82(1–2): 3– 17. DOI: https://doi.org/10.1016/S0167-7322(99)00037-978. Agrafonov Yu., Petrushin I. Two-particledistribution function of a non-ideal molecular systemnear a hard surface. Physics Procedia. 2015;71. 364–368. DOI: https://doi.org/10.1016/j.phpro.2015.08.35379. Agrafonov Yu., Petrushin I. Close order in themolecular system near hard surface. Journal of Physics:Conference Series. 2016;747: 012024. DOI: https://doi.org/10.1088/1742-6596/747/1/01202480. He Y., Rice S. A., Xu X. Analytic solution of theOrnstein-Zernike relation for inhomogeneous liquids.The Journal of Chemical Physics. 2016;145(23): 234508.DOI: https://doi.org/10.1063/1.497202081. Agrafonov Y. V., Petrushin I. S. Usingmolecular distribution functions to calculate thestructural properties of amorphous solids. Bulletinof the Russian Academy of Sciences: Physics. 2020;84:783–787. DOI: https://doi.org/10.3103/S106287382007003582. Bertheir L., Ediger M. D. How to “measure” astructural relaxation time that is too long to bemeasured? arXiv:2005.06520v1. DOI: https://arxiv.org/abs/2005.0652083. Karmakar S., Dasgupta C., Sastry S. Lengthscales in glass-forming liquids and related systems: areview. Reports on Progress in Physics. 2015;79(1):016601. DOI: https://doi.org/10.1088/0034-4885/79/1/01660184. De Michele C., Sciortino F., Coniglio A. Scalingin soft spheres: fragility invariance on the repulsivepotential softness. Journal of Physics: CondensedMatter. 2004;16(45): L489. DOI: https://doi.org/10.1088/0953-8984/16/45/L0185. Niblett S. P., de Souza V. K., Jack R. L., Wales D. J.Effects of random pinning on the potential energylandscape of a supercooled liquid. The Journal ofChemical Physics. 2018;149(11): 114503. DOI: https://doi.org/10.1063/1.504214086. Wolynes P. G., Lubchenko V. Structural glassesand supercooled liquids: Theory, experiment, andapplications. New York: John Wiley & Sons; 2012. 404p. DOI: https://doi.org/10.1002/978111820247087. Jack R. L., Garrahan J. P. Phase transition forquenched coupled replicas in a plaquette spin modelof glasses. Physical Review Letters. 2016;116(5): 055702.DOI: https://doi.org/10.1103/PhysRevLett.116.05570288. Habasaki J., Ueda A. Molecular dynamics studyof one-component soft-core system: thermodynamicproperties in the supercooled liquid and glassy states.The Journal of Chemical Physics. 2013;138(14): 144503.DOI: https://doi.org/10.1063/1.479988089. Bomont J. M., Hansen J. P., Pastore G. Aninvestigation of the liquid to glass transition usingintegral equations for the pair structure of coupledreplicae. J. Chem. Phys. 2014;141(17): 174505. DOI:https://doi.org/10.1063/1.490077490. Parisi G., Urbani P., Zamponi F. Theory of SimpleGlasses: Exact Solutions in Infinite Dimensions.Cambridge: Cambridge University Press; 2020. 324 p.DOI: https://doi.org/10.1017/978110812049491. Robles M., López de Haro M., Santos A., BravoYuste S. Is there a glass transition for dense hardspheresystems? The Journal of Chemical Physics.1998;108(3): 1290–1291. DOI: https://doi.org/10.1063/1.47549992. Grigera T. S., Martín-Mayor V., Parisi G.,Verrocchio P. Asymptotic aging in structural glasses.Physical Review B, 2004;70(1): 014202. DOI: https://doi.org/10.1103/PhysRevB.70.01420293. Vega C., Abascal J. L., McBride C., Bresme F.The fluid–solid equilibrium for a charged hard spheremodel revisited. The Journal of Chemical Physics.2003; 119 (2): 964–971. DOI: https://doi.org/10.1063/1.157637494. Kaneyoshi T. Surface amorphization in atransverse Ising nanowire; effects of a transverse field.Physica B: Condensed Matter. 2017;513: 87–94. DOI:https://doi.org/10.1016/j.physb.2017.03.01595. Paganini I. E., Davidchack R. L., Laird B. B.,Urrutia I. Properties of the hard-sphere fluid at a planarwall using virial series and molecular-dynamicssimulation. The Journal of Chemical Physics. 2018;149(1):014704. DOI: https://doi.org/10.1063/1.502533296. Properzi L., Santoro M., Minicucci M., Iesari F.,Ciambezi M., Nataf L., Di Cicco A. Structural evolutionmechanisms of amorphous and liquid As2 Se3 at highpressures. Physical Review B. 2016;93(21): 214205. DOI:https://doi.org/10.1103/PhysRevB.93.21420597. Sesé L. M. Computational study of the meltingfreezingtransition in the quantum hard-sphere systemfor intermediate densities. I. Thermodynamic results.The Journal of Chemical Physics. 2007;126(16): 164508.DOI: https://doi.org/10.1063/1.271852398. Shetty R., Escobedo F. A. On the application ofvirtual Gibbs ensembles to the direct simulation offluid–fluid and solid–fluid phase coexistence. TheJournal of Chemical Physics. 2002;116(18): 7957–7966.DOI: https://doi.org/10.1063/1.1467899

At the time of recovery, immature equine oocytes may be separated into those with either expanded cumuli (Ex) or compact cumuli (Cp). The Cp oocytes originate from viable follicles but are largely juvenile, with low meiotic competence (20 to 30% maturation to MII), and possibly reduced developmental competence. We previously found that in Cp oocytes recovered immediately after slaughter, suppression of meiosis with roscovitine for 24 h before maturation increased embryo development at 4 days after intracytoplasmic sperm injection (ICSI; Franz et al. 2003 Reproduction 125, 693–700). The present study was conducted to evaluate the effect of roscovitine suppression on nuclear maturation and blastocyst formation of Cp oocytes recovered after transport of ovaries from the abattoir (i.e. recovered 5–9 h after slaughter). Compact oocytes recovered from transported ovaries were cultured in M199 with 10% FBS containing 66 μM roscovitine with or without an oil cover. After 16–18 or 24 h, oocytes were fixed to examine the chromatin configuration. Treatment for 16–18 h without oil resulted in the lowest rate of meiotic resumption (0%); thus this treatment was utilized in further studies. Resumption in other treatments ranged from 3 to 6%. Following roscovitine suppression, oocytes were cultured for 30 h in M199 with 10% FBS and 5 μU mL−1 FSH for maturation; control oocytes were cultured for 30 h in the same medium immediately after recovery. Mature oocytes were subjected to ICSI, then cultured in DMEM/F-12 with 10% FBS with or without co-culture with equine oviductal epithelial cells under mineral oil in 5% CO2 in air at 38.2°C, and then evaluated at 7.5 days. Progression to MII (82/376, 22%) after maturation of roscovitine-treated oocytes was similar to that for control oocytes (74/395, 19%). There was no significant difference in cleavage rates after ICSI (72–78%) among treatments. Development to blastocyst was highest in roscovitine-treated oocytes in DMEM/F-12 with co-culture (11/30, 37%); this was significantly higher than that of non-treated oocytes in DMEM/F-12 alone (5/36, 14%), but similar to that of non-treated/DMEM/F-12/co-culture (10/37, 27%) and roscovitine/DMEM/F-12 alone (8/39, 21%). These data indicate that roscovitine induces a fully reversible meiotic suppression in Cp equine oocytes recovered 5–9 h after slaughter, and that this suppression does not harm subsequent developmental competence. This treatment may be used to manipulate the time of onset of maturation of equine oocytes for ease of subsequent procedures. Co-culture with oviductal epithelial cells tended to increase blastocyst rate (P = 0.1, Fisher's exact test) in contrast to our previous findings with embryos from Ex oocytes (Choi et al. 2004 Biol. Reprod. 70, 1231–1238). Further work is needed to determine whether this is related to differences in intrinsic developmental competence between oocyte types. This work was supported by the Link Equine Research Endowment Fund (Texas A&M University).

RESUMENLa historia del cristianismo no se entiende sin el complejo fenómeno mariano. El culto mariano ha afianzado la construcción de identidades colectivas, pero también individuales. La figura de la Virgen María estableció un modelo de conducta desde cada contexto histórico-cultural, remarcando especialmente los ideales de maternidad y virginidad. Dentro del imaginario católico, la Europa contemporánea ha estado marcada por la formación de una cultura aparicionista que se ha generadoa partir de diversas apariciones marianas que han establecido un canon y un marco de interpretación que ha alimentado las guerras culturales entre secularismo y catolicismo.PALABRAS CLAVE: catolicismo, Virgen María, cultura aparicionista, Lourdes, guerras culturales.ABSTRACTThe history of Christianity cannot be understood without the complex Marian phenomenon. Marian devotion has reinforced the construction of collective, but also of individual identities. The figure of the Virgin Mary established a model of conduct through each historical-cultural context, emphasizing in particular the ideals of maternity and virginity. Within the Catholic imaginary, contemporary Europe has been marked by the formation of an apparitionist culture generated by various Marian apparitions that have established a canon and a framework of interpretation that has fuelled the cultural wars between secularism and Catholicism.KEY WORDS: Catholicism, Virgin Mary, apparicionist culture, Lourdes, culture wars. BIBLIOGRAFÍAAlbert Llorca, M., “Les apparitions et leur histoire”, Archives de Sciences Sociales des religions, 116 (2001), pp. 53-66.Albert, J.-P. y Rozenberg G., “Des expériences du surnaturel”, Archives de Sciences Sociales des Religions, 145 (2009), pp. 9-14.Amanat A. y Bernhardsson, M. T. (eds.), Imagining the End. Visions of Apocalypsis from the Ancient Middle East to Modern America, London and New York, I. B. Tauris, 2002.Angelier, F. y Langlois, C. (eds.), La Salette. Apocalypse, pèlerinage et littérature (1846-1996), Actes du colloque de l’institut catholique de Paris (29- 30 de novembre de 1996), Grenoble, Jérôme Million, 2000.Apolito, P., Apparitions of the Madonna at Oliveto Citra. Local Visions and Cosmic Drama, University Park, Penn State University Press, 1998.Apolito, P., Internet y la Virgen. Sobre el visionarismo religioso en la Red, Barcelona, Laertes, 2007.Astell, A. W., “Artful Dogma: The Immaculate Conception and Franz Werfer´s Song of Bernadette”, Christianity and Literature, 62/I (2012), pp. 5-28.Barnay, S., El cielo en la tierra. Las apariciones de la Virgen en la Edad Media, Madrid, Encuentro, 1999.Barreto, J., “Rússia e Fátima”, en C. Moreira Azevedo e L Cristino (dirs.), Enciclopédia de Fátima, Estoril, Princípia, 2007, pp. 500-503.Barreto, J., Religião e Sociedade: dois ensaios, Lisboa, Instituto de Ciências Sociais da Universidade de Lisboa, 2003.Bayly, C. A., El nacimiento del mundo moderno. 1780-1914, Madrid, Siglo XXI, 2010.Béjar, S., Los milagros de Jesús, Barcelona, Herder, 2018.Belli, M., An Incurable Past. Nasser’s Egypt. Then and Now, Gainesville, University Press of Florida, 2013.Blackbourn, D., “Apparitions of the Virgin Mary in Bismarckian Germany”, en Eley, G. (ed.), Society, Culture, and the State in Germany, 1870-1930, Ann Arbor, The University Michigan Press, 1997.Blackbourn, D., Marpingen: Apparitions of the Virgin Mary in Nineteenth-Century Germany, New York, Alfred A. Knopf, 1994.Bouflet, J., Une histoire des miracles. Du Moyen Âge à nos jours, Paris, Seuil, 2008.Boyd, C. P., “Covadonga y el regionalismo asturiano”, Ayer, 64 (2006), pp. 149-178.Brading, D. A., La Nueva España. Patria y religión, México D. F., Fondo de Cultura Económica, 2015.Brading, D. A., Mexican Phoenix, our Lady of Guadalupe: image and tradition across five centuries, Cambridge, Cambridge University Press, 2001.Bugslag, J., “Material and Theological Identities: A Historical Discourse of Constructions of the Virgin Mary”, Théologiques, 17/2 (2009), pp. 19-67.Cadoret-Abeles, A., “Les apparitions du Palmar de Troya: analyse anthropologique dun phenómène religieux”, Mélanges de la Casa de Velázquez, 17 (1981), pp. 369-391.Carrión, G., El lado oscuro de María, Alicante, Agua Clara, 1992.Chenaux, P., L´ultima eresia. La chiesa cattolica e il comunismo in Europa da Lenin a Giovanni Paolo II, Roma, Carocci Editore, 2011.Christian, W. A., “De los santos a María: panorama de las devociones a santuarios españoles desde el principio de la Edad Media a nuestros días”, en Lisón Tolosana, C. (ed.), Temas de antropología española, Madrid, Akal, 1976, pp. 49-105.Christian, W. A., “Religious apparitions and the Cold War in Southern Europe”, Zainak, 18 (1999), pp. 65-86.Christian, W. A., Apariciones Castilla y Cataluña (siglo XIV-XVI), Madrid, Nerea, 1990.Christian, W. A., Religiosidad local en la España de Felipe II, Madrid, Nerea, 1991.Christian, W. A., Religiosidad popular: estudio antropológico en un valle, Madrid, Tecnos, 1978.Christian, W. A., Visionaries: The Spanish Republic and the Reign of Christ, Berkeley, University of California Press, 1997.Clark, C., “The New Catholicism and the European Culture Wars”, en C. Clark y Kaiser, W. (eds.), Culture Wars. Secular-Catholic conflict in Nineteenth-Century Europe, Cambridge, Cambridge University Press, 2003, pp. 11-46.Claverie, É., Les guerres de la Vierge. Une anthropologie des apparitions, Paris, Gallimard, 2003.Colina, J. M. de la, La Inmaculada y la Serpiente a través de la Historia, Bilbao, El Mensajero del Corazón de Jesús, 1930.Collins, R., Los guardianes de las llaves del cielo, Barcelona, Ariel, 2009, p. 521.Corbin, A. (dir.), Historia del cuerpo. Vol. II. De la Revolución francesa a la Gran Guerra, Madrid, Taurus, 2005.Coreth, E. (ed.), Filosofía cristiana en el pensamiento católico de los siglos XIX y XX. Tomo I: Nuevos enfoques en el siglo XIX, Madrid, Encuentro, 1994.Coreth, E. (ed.), Filosofía cristiana en el pensamiento católico de los siglos XIX y XX. Tomo II: Vuelta a la herencia escolástica, Madrid, Encuentro, 1994.Cunha, P. y Ribas, D., “Our Lady of Fátima and Marian Myth in Portuguese Cinema”, en Hansen, R. (ed.), Roman Catholicism in Fantastic Film: Essays on. Belief, Spectacle, Ritual and Imagery, Jefferson, McFarland, 2011.D’Hollander, P. y Langlois, C. (eds.), Foules catholiques et régulation romaine. Les couronnements de vierges de pèlerinage à l’époque contemporaine (XIXe et XXe siècles), Limoges, Presses universitaires de Limoges, 2011.D´Orsi, A., 1917, o ano que mudou o mundo, Lisboa, Bertrand Editora, 2017.De Fiores, S., Maria. Nuovissimo dizionario, Bologna, EDB, 2 vols., 2006.Delumeau, J., Rassurer et protéger. Le sentiment de sécurité dans l’Occident d’autrefois, Paris, Fayard, 1989.Dozal Varela, J. C., “Nueva Jerusalén: a 38 años de una aparición mariana apocalíptica”, Nuevo Mundo, Mundos Nuevos, 2012, s.p.Driessen, H., “Local Religion Revisited: Mediterranean Cases”, History and Anthropology, 20/3 (2009), pp. 281-288.Driessen, H., “Local Religion Revisited: Mediterranean Cases”, History and Anthropology, 20/3 (2009), p. 281-288.González Sánchez, C. A., Homo viator, homo scribens. Cultura gráfica, información y gobierno en la expansión atlántica (siglos XV-XVII), Madrid, Marcial Pons, 2007.Grignion de Montfort, L. M., Escritos marianos selectos, Madrid, San Pablo, 2014.Harris, R., Lourdes. Body and Spirit in the Secular Age, London, Penguin Press, 1999.Harvey, J., Photography and Spirit, London, Reaktion Books, 2007.Hood, B., Supersense: Why We Believe in the Unbelievable, New York, HarperOne, 2009.Horaist, B., La dévotion au Pape et les catholiques français sous le Pontificat de Pie IX (1846-1878), Palais Farnèse, École Française de Rome, 1995.Kselman, T., Miracles and Prophecies in Nineteenth Century France, New Brunswick, Rutgers University Press, 1983.Lachapelle, S., Investigating the Supernatural: From Spiritism and Occultism to Psychical Research and Metapsychics in France, 1853-1931, Baltimore, The John Hopkins University Press, 2011.Langlois, C., “Mariophanies et mariologies au XIXe siècles. Méthode et histoire”, en Comby, J. (dir.), Théologie, histoire et piété mariale, Lyon, Profac, 1997, pp. 19-36.Laurentin, R. y Sbalchiero, P. (dirs.), Dictionnaire des “aparitions” de la Vierge Marie, Paris, Fayard, 2007.Laycock, J. P., The Seer of Bayside: Veronica Lueken and the Struggle to Define Catholicism, Oxford, Oxford University Press, 2015.Levi, G., La herencia inmaterial. La historia de un exorcista piamontés del siglo XVII, Madrid, Nerea, 1990.Linse, U., Videntes y milagreros. La búsqueda de la salvación en la era de la industrialización, Madrid, Siglo XXI, 2002.Louzao, J., “La España Mariana: vírgenes y nación en el caso español hasta 1939”, en Gabriel, P., Pomés, J. y Fernández, F. (eds.), España res publica: nacionalización española e identidades en conflicto (siglos XIX y XX), Granada, Comares, 2013, pp. 57-66.Louzao, J., “La recomposición religiosa en la modernidad: un marco conceptual para comprender el enfrentamiento entre laicidad y confesionalidad en la España contemporánea”, Hispania Sacra, 121 (2008), pp. 331-354.Louzao, J., “La Señora de Fátima. La experiencia de lo sobrenatural en el cine religioso durante el franquismo”, en Moral Roncal, A. M. y Colmenero, R. (eds.), Iglesia y primer franquismo a través del cine (1939-1959), Alcalá de Henares, Universidad de Alcalá de Henares, 2015, pp. 121-151.Louzao, J., “La Virgen y la salvación de España: un ensayo de historia cultural durante la Segunda República”, Ayer, 82 (2011), pp. 187-210.Louzao, J., Soldados de la fe o amantes del progreso. Catolicismo y modernidad en Vizcaya (1890-1923), Logroño, Genueve Ediciones, 2011.Lowenthal, D., El pasado es un país extraño, Madrid, Akal, 1998.Lundberg, M., A Pope of their Own. El Palmar de Troya and the Palmarian Church, Uppsala, Uppsala University, 2017.Maravall, J. A., La cultura del Barroco, Madrid, Ariel, 1975.Martí, J., “Fundamentos conceptuales introductorios para el estudio de la religión”, en Ardèvol, E. y Munilla, G. (coords.), Antropología de la religión. Una aproximación interdisciplinar a las religiones antiguas y contemporáneas, Barcelona, Editorial Universitat Oberta Catalunya, 2003.Martina, G., Pio IX (1846-1850), Roma, Università Gregoriana, 1974.Martina, G., Pio IX (1851-1866), Roma, Università Gregoriana,1986.Martina, G., Pio IX (1867-1878), Roma, Università Gregoriana, 1990.Maunder, C., “The Footprints of Religious Enthusiasm: Great Memorials and Faint Vestiges of Belgium´s Marian Apparition Mania of the 1930s”, Journal of Religion and Society, 15 (2013), s.p.Maunder, C., Our Lady of the Nations: Apparitions of Mary in Twentieth-century Catholic, Oxford, Oxford University Press, 2016.Mínguez, R., “Las múltiples caras de la Inmaculada: religión, género y nación en su proclamación dogmática (1854)”, Ayer, 96 (2014), pp. 39-60.Moreno Luzón, J., “Entre el progreso y la virgen del Pilar. La pugna por la memoria en el centenario de la Guerra de la Independencia”, Historia y política, 12 (2004), pp. 41-78.Moro, R., “Religion and Politics in the Time of Secularisation: The Sacralisation of Politics and the Politicisation of Religion”, Totalitarian Movements and Political Religions, 6/1 (2005), pp. 71-86.Multon, H., “Catholicisme intransigeant et culture prophétique: l’apport des Archives du Saint Office et de l’Index”, Revue historique, 621 (2002), pp. 109-137.Osterhammel, J., The Transformation of the World: A Global History of the Nineteenth Century, Princeton, Princeton University Press, 2014.Oviedo Torró, L., “Natural y sobrenatural: un repaso a los debates recientes”, en Alonso Bedate, A. (ed.), Lo natural, lo artificial y la cultura, Madrid, Universidad Pontificia Comillas, pp. 151-166.Pelikan, J., María a través de los siglos. Su presencia en veinte siglos de cultura, Madrid, PPC, 1997.Perica, V., Balkan Idols: Religion and Nationalism in Yugoslav States, Oxford, Oxford University Press, 2002.Rahner, K., Tolerancia, libertad, manipulación, Barcelona, Herder, 1978.Ramón Solans, F. J. y di Stefano, R. (eds.), Marian Devotions, Political Mobilization, and Nationalism in Europe and America, Basingstoke, Palgrave, 2016.Ramón Solans, F. J., “A New Lourdes in Spain: The Virgin of El Pilar, Mass Devotion, National Symbolism and Political Mobilization”, en Ramón Solans, F. J. y di Stefano, R. (eds.), Marian Devotions, Political Mobilization, and Nationalism in Europe and America, Basingstoke, Palgrave, 2016, pp. 137-167.Ramón Solans, F. J., “La hidra revolucionaria. Apocalipsis y antiliberalismo en la España del primer tercio del siglo XIX”, Hispania, 56 (2017), pp. 471-496.Ramón Solans, F. J., La Virgen del Pilar dice... Usos políticos y nacionales de un culto mariano en la España contemporánea, Zaragoza, Prensas Universitarias de Zaragoza, 2014.Ridruejo, E., Apariciones de la Virgen María: una investigación sobre las principales Mariofanías en el mundo Zaragoza, Fundación María Mensajera, 2000.Ridruejo, E., Memorias de Pitita, Madrid, Temas de Hoy, 2002.Rodríguez Becerra, S., “Las leyendas de apariciones marianas y el imaginario colectivo”, Etnicex: Revista de Estudios Etnográficos, 6 (2014), pp. 101-121.Rousseau, J. J., Ouvres Completes. Tome VII, Frankfort, H. Bechhold, 1856.Rubial García, A., Profetisas y solitarios: espacios y mensajes de una religión dirigida por ermitaños y beatas laicos en las ciudades de Nueva España, México D. F., Fondo de Cultura Económica, 2006.Rubin, M., Mother of God. A History of the Virgin Mary, London, Penguin, 2010.Russell, J. B., The Prince of Darkness: Radical Evil and the Power of Good in History, Cornell, Cornell University Press, 1992.Sánchez-Ventura, F., El pensamiento de María mensajera, Zaragoza, Fundación María Mensajera, 1997.Sánchez-Ventura, F., María, precursora de Cristo en su segunda venida a la tierra. Estudio de las profecías en relación con el próximo retorno de Jesús, Zaragoza, Círculo, 1973.Skinner, Q., Visions of Politics. Volumen 1: Regarding Method, Cambridge, Cambridge University Press, 2002.Staehlin, C. M., Apariciones. Ensayo crítico, Madrid, Razón y Fe, 1954.Stark R. y Finke, R., Acts of Faith: Explaining Human Side of Religion, Berkeley, University of California Press, 2000.Thomas, K., Religion and the Decline of Magic, New York, Scribner’s, 1971.Torbado, J., Milagro, milagro, Barcelona, Plaza y Janés, 2000.Turner, V. y Turner, E., Image and Pilgrimage in Christian Culture. Anthropological perspectives, New York, Columbia University Press, 1978.Vélez, P. V., Realidades, Barcelona, Imprenta Moderna, 1906.Walker, B., Out of the Ordinary Folklore and the Supernatural, Utah, Utah State University Press, 1995.Walliss, J., “Making Sense of the Movement for the Restoration of the Ten Commandments of God”, Nova Religio: The Journal of Alternative and Emergent Religions, 9/1 (2005), pp. 49-66.Warner, M., Tú sola entre las mujeres: el mito y el culto de la Virgen María, Madrid, Taurus, 1991.Watkins, C. S., History and the Supernatural in Medieval England, Cambridge, Cambridge University Press, 2007.Weber, M., Ensayos sobre sociología religiosa, Madrid, Taurus, 1983.Weigel, G., Juan Pablo II. El final y el principio, Barcelona, Planeta, 2011.Werfel, F., La canción de Bernardette, Madrid, Palabra, 1988.Zimdars-Swartz, S. L., Encountering Mary: From La Salette to Medjugorje, Princenton, Princeton University Press, 2014.

The history of the plant cover studies of the Far North in the Komarov Botanical Institute (BIN) and its predecessors dates back to the second third of the XIX century and it is associated with the names of two eminent botanists — A. Schrenk and F. Ruprecht, who in 1837 and 1841 years made their long trips to the north of the European part of Russia. A long break in the study of the Arctic, which came after that, has been resumed within our institute only in the Soviet period. Already before the Great Patriotic war the scientific expeditions were organized both on the European North and on the Asian part of the Arctic up to the eastern borders of the country. In the 1920–1930th the brightest star in the sky of the Russian tundrology – B. N. Gorodkov worked on the vast area fr om the Kola Peninsula up to the Wrangel Island. This vigorous activity resulted in excellent descriptions of plant cover, and the classic, still actively quoted monograph «The vegetation of the tundra zone of the USSR» was published in 1935. In 1930–1931 years a lot of scientists (F. V. Sambuk, A. I. Leskov, K. N. Igoshina, M. N. Avramchik, V. P. Savich, Z. N. Smirnova and others) participated in various botanical expeditions (the Franz Josef Land, the Novaya Zemlya, the Kolguev Isl., the Malozemelskaya tundra, the interior parts of Taymyr Peninsula). The Great Patriotic war had interrupted botanical work in the Arctic. However the numerous expeditions took place as early as in the first post-war years (1946– 1949). At that time, besides mentioned researchers, B. A. Tikhomirov has already participated in these studies. Later (1952) B. A. headed the Sector of North, transformed in 1960 into the Laboratory of the vegetation of Far North. This Laboratory is the exclusive botanical team not only in Russia but throughout the world, which all over its existence was being specialized in comprehensive study of plant cover in the Arctic, coordinating the northern investigations within the whole country. The outstanding achievement, received international recognition, is undoubtedly the multi-volume edition «Arctic Flora of the USSR» (1960–1987), initiated by the eminent botanist A. I. Tolmachev and completed through intense activity by B. A. Yurtsev. This great work, later translated into English, was done during the large-scale floristic studies in different regions of the Asian Arctic fr om the Yamal, Gydan and Taymyr peninsulas in the west to Chukotka in the east. The implementation of annual field work became possible due to the establishment of Polar Expedition, funded by a «separate item» within the budget of the Institute. A period fr om 1966 to 1991 year without exaggeration may be called as «golden age» in the study of vegetation of the Russian Arctic. This was a time when not only numerous research teams carrying out the floristic studies, but up to 3 long-term research stations simultaneously worked in one field season. The durable stationary studies were performed in the Bolshezemelskaya Tundra (Sivaya Maska), on the Taymyr Peninsula (Tareya and Agapa settlements and Ary-Mas forest «island»), Putorana plateau (Kapchuk lake) and Wrangel Island (Somnitelnaya Bay). According to the results of these stationary studies 11 collective Proceedings have been published. Most lasting (1965–1977) and large-scale investigations were biogeocenological studies at the «Tareya» station, wh ere in the period of the International Biological Program the organizational skills by B. A. Tikhomirov collected up to 40 specialists from different branches of biology and ecology. In the years 1972–1991 these works were continued on Taymyr Peninsula at 6 short-term field stations at the latitudinal gradient from southern tundra up to polar deserts, which became the basis for a comprehensive study of zonation display in the living cover. As a result of extensive studies by the method of concrete floras the data on the composition of vascular plants for nearly 170 sites in all latitude-zonal stripes of Asian North from Yamal up to Chukotka has been obtained. At present these data are the fundamental basis for work on the detailed floristic subdivisions that was started by the great trio — B. A. Yurtsev, A. I. Tolmachev and O. V. Rebristaya in their famous paper «Arctic floristic region» (1978). The end of the last and the beginning of this century became a time of summing up the study of arctic flora and vegetation. The checklists of fungi, lichens, mosses and liverworts of Russian Arctic were compiled; the monographs on the vascular flora of Chukotka and Yamal as well as the book on mosses of Chukotka were published. The electronic version of Pan-Arctic flora and the Circumpolar vegetation map of the Arctic were prepared with the active participation of BIN florists and geobotanists. In the last ten years the obvious lack of information on the diversity of plant communities at the vast arctic territory is being compensated by publishing the numerous papers on syntaxonomy. The intensity of field works, declined sharply in the early 1990s, still continues, albeit in smaller scale. For the first time in the history of the study of the Far North nature the recurrent botanical observations were made in few sites wh ere many-sided studies were performed in the past. This allows assessing the dynamics in the flora and vegetation in situ. The changes in plant cover are well recorded by the earth’s surface remote sensing using multispectral satellite imagery. The analysis of image series allows us to monitor changes in intra-landscape vegetation patterns as well as some technological and cryogenic transformations. In the development of the concepts of classical Arctic and Antarctic geobotanical subdivision suggested by V. D. Aleksandrova for higher system units, the work on the designation of the lower units is being intensified presently. An assessment of current environmental safety of Arctic ecosystems in the areas with heavy anthropogenic load caused by oil and gas production will be the most required in the nearest future. However, there are still large areas within the vast Arctic territories wh ere classic fundamental studies are necessary to close the «white spots» in our knowledge of plant cover. The growing geopolitical interest to the Arctic region gives the hope for the revival of full-scale researches, which are impossible without adequate funding. More than one and a half century of brilliant botanical investigations in the Arctic were carried out by our famous predecessors. This fact allows us to look optimistically for the future and expect the growth of the scientific activities in the Far North.

ObjectiveDue to the lack of information about the phylogenetic origins of Ukrainian Bacillus anthracis strains,the goal of this work was to make phylogenetic analysis of Ukrainian isolates obtained from various sources (soil, clinical material from infected humans and animal products) for better understanding of phylogenetic origins of this pathogen in Ukraine and Eastern Europe.IntroductionAnthrax is a widely spread zoonotic disease with natural transmissive cycle involving wildlife, livestock and humans [1]. It is caused by Bacillus anthracis, a highly pathogenic gram-positive, spore-producing bacterium, which poses a serious threat to public and animal health due to its mortality both for animals and for humans [2, 3, 4]. The ability of B. anthracis spores to remain viable in soils for decades enables their isolation from freely accessible environment [5]. This unique feature to form highly resistant spores in the environment plays a major role in the ecology and evolution of this pathogen [6]. During the spore phase, evolution is greatly reduced in rate, which limits the amount of genetic diversity found among isolates of this species [1]. All these factors demonstrate the need for reliable anthrax diagnosis and trace-back methods. This comprises bio forensic capabilities including state-of-the-art methods for accurate genotyping of B. anthracis strains.Methods23 thermolysates of B. anthracis broth cultures isolated from various sources (vesicles from eleven different people infected with cutaneous anthrax when disease’s sporadic outbreaks were detected in Ukraine in 1963-2002, as well as two samples from sheep wool, and eight soil samples) were obtained from the Central Epidemiological Station (Kyiv, Ukraine), as well as from I.I. Mechnikov Ukrainian Scientific and Research Anti-plaque Institute (Odessa, Ukraine). These anthrax cultures were confirmed with classical microbiological methods (microscopy, cultivation on solid and liquid media), “string of pearls” reaction, and using bioassay on living white mice (the mortality was observed two days after subcutaneous injection of 0,2-0,5 ml of cells’ suspension). All these tests were carried out at the institutions where samples were obtained. Besides, one B. anthracis isolate was cultivated from soil sample of an animal grave site nearby Koviagy village, Valky district, Kharkiv region. All samples were analyzed at the Bundeswehr Institute of Microbiology (Munich, Germany). To confirm the presence of the anthrax genome and plasmids, we isolated genomic DNA (gDNA) from thermolysates and studied the presence of the genomic marker dhp61 as well as the plasmid specific marker pagA (pXO1) and capC (pXO2) using qPCR. Quality of the isolated gDNA was tested using the Agilent bioanalyzer. To characterize regional and global phylogeographic patterns of these strains, canonical Single Nucleotide Polymorphisms analysis (canSNP) was conducted using high resolution melt (HRM). Three thermolysates of broth cultures isolated and soil sample isolated from animal grave site in Kharkiv region were analyzed using NewSeq Full genome sequencing.ResultsB. anthracis chromosomal DNA-marker dhp61 as well as pXO1 marker pagA and pXO2 plasmid marker capC could be detected in all thermolysates. However, the soil isolate from the Koviagy grave site was positive for dhp61 but contained only the pXO1 plasmid. The Bioanalyzer assay revealed that only 6 out of the 23 thermolysates had good enough DNA quality to be sequenced. So far only genomes of thermolysates of soil samples from Mykolaiv and Sumy regions, the thermolysate of sick patient's vesicle from Kherson region as well as the soil sample from the animal grave site in Kharkiv region have been sequenced. For the residual 3 thermolysates the full genome analysis is still in progress. The sequencing results showed that the B. anthracis strain isolated from Mykolaiv soil sample belongs to the Vollum linage group and other thermolysates from Sumy and Kherson regions are closely clustering with isolates from Japan. Thus, human isolate from Kherson region is clustering with the Japanese isolate BA104 which was obtained from pig during sporadic anthrax incident in 1982 and soil isolate from Sumy region is clustering with the BA 103 isolate which was obtained from beef cattle in Japan in 1991. In contrast, we analyzed the genomic sequence of the pXO2-negative isolate from grave site in Kharkiv region using BioNumerics software and found that it has high similarity to STI strain.ConclusionsThe infrequent sporadic occurrence of anthrax in the country of Ukraine is likely caused by a heterogeneous population of B. anthracis. The found STI strain in the grave site of Kharkiv region is probably an environmental recovery of the Russian anthrax live vaccine which was commonly used for vaccination of animals in the former Soviet Union The sequencing result of the soil isolate from Mykolaiv region indicates the occurrence of another canSNP group, the Vollum group, which is quite untypical for Ukraine. The latter is mainly prevalent in the Asian regions (namely Pakistan) and therefore might have been introduced to Ukraine over the silk road. Other two thermolysates from Sumy and Kherson regions also showed unexpected results clustering with Japanese isolates. The further research of Ukrainian B. anthracis isolates will allow us to expand our knowledge about the population structure and evolution of anthrax in Ukraine.References1. Van Ert MN, Easterday WR, Huynh LY, Okinaka RT, Hugh-Jones ME, Ravel J, et al. (2007) Global Genetic Population Structure of Bacillus anthracis. PLoS ONE 2(5);2. Freidlander, A. M. 1997. Anthrax, p. 467–478. In F. R. Sidell, E. T. Takafuji, and D. R. Franz (ed.), Medical aspects of chemical and biological warfare. Office of the Surgeon General, Washington, D.C.3. Hoffmaster AR, Fitzgerald CC, Ribot E, Mayer LW, Popovic T (2002) Molecular subtyping of Bacillus anthracis and the 2001 bioterrorism-associated anthrax outbreak, United States. Emerg Infect Dis 8: 1111–1116.4. Keim P, Van Ert MN, Pearson T, Vogler AJ, Huynh LY, et al. (2004) Anthrax molecular epidemiology and forensics: using the appropriate marker for different evolutionary scales. Infect Genet Evol 4: 205–213.5. Eitzen, E. M. 1997. Use of biological weapons, p. 437–450. In F. R. Sidell, E. T. Takafuji, and D. R. Franz (ed.), Medical aspects of chemical and biological warfare. Office of the Surgeon General, Washington, D.C.6. Biloivan O, Duerr A, Schwarz J, Grass G, Arefiev V, Solodiankin O, Stegniy B, Gerilovych A (2018) Phylogenetic analysis of Ukrainian Bacillus anthracis strains. Third Annual BTRP Ukraine Regional One Health Research Symposium, abstract directory: 122.

Durante os procedimentos odontológicos são utilizados diversos produtos como resinas, cimentos, adesivos, entre outros, e após a utilização deixam sujidades inorgânicas de difícil remoção, principalmente se a limpeza não for realizada imediatamente ou logo após o uso. O presente trabalho objetivou analisar a efetividade de um produto pré-limpeza aplicado após a utilização da espátula para resina, espátula 24, pote dappene placa de vidro expostos às diferentes sujidades inorgânicas. Em todos os casos, o produto pré-limpeza mostrou-se eficaz em manter a superfície úmida durante 1 hora, possibilitando fácil remoção da sujidade inorgânica na etapa de limpeza, dispensando o uso de ação abrasiva sobre as peças, preservando a integridade dos instrumentais.Descritores: Consultórios Odontológicos; Instrumentos Odontológicos; Detergentes; Tensoativos.ReferênciasBrasil. Ministério da Saúde. Agência Nacional de Vigilância Sanitária. Serviços Odontológicos: Prevenção e Controle de Riscos. Brasília: Ministério da Saúde, 2006.156 p.Spruce L. Back to basics: instrument cleaning. AORN J.2017;105(3):292-99.Sociedade Brasileira de Enfermeiros de Centro Cirúrgico, Recuperação Anestésica e Centro de Material e Esterilização (SOBECC). Diretrizes de práticas em enfermagem cirúrgica e processamento de produtos para saúde. 7 ed. São Paulo:SOBECC;2017.EDLO. Recomendações para limpeza de instrumentais pré-esterilização. Disponível em: http://www.edlo.com.br. Acesso em 2 agosto 2018.CDC. Recommended infection-control practices for dentistry, 1993. MMWR 1993;42(No. RR-8).Disponível em: https://www.cdc.gov/ mmwr/PDF/rr/rr4208.pdf . Acesso em 2 agosto 2018.Cowperthwaite L, Holm RL. Guideline implementation: surgical instrument cleaning. AORN J.2015;101(5):542-49Brasil. Ministério da Saúde. Agência Nacional de Vigilância Sanitária. Resolução RDC n. 15, de 15 de março de 2012. Dispõe sobre requisitos de boas práticas para o processamento de produtos para saúde e dá outras providências [Internet]. Brasília;2012. Disponível em: http://www.anvisa.gov.br. Acesso em 2 agosto 2018.AST (Association of Surgical Technologists). Standards of Practice for the Decontamination of Surgical Instruments. Disponível em: https://www.ast.org/AboutUs/Sterilization_and_Disinfection/. Acesso em 2 agosto 2018.Bhatnagar S, Bagga DK, Sharma P, Kumar P, Sharma R, Singh V. Infection control strategy in orthodontic office. Eur J Gen Dent.2013;2:1-7Secker TJ, Pinchin HE, Hervé RC, Keevil CW. Efficacy of humidity retention bags for the reduced adsorption and improved cleaning of tissue proteins including prion-associated amyloid to surgical stainless steel surfaces. Biofouling. 2015;31(6):535-41.Smith A, Letters S, Lange A, Perrett D, McHugh S, Bagg J. Residual protein levels on reprocessed dental instruments. J Hosp Infect. 2005;61(3):237-41.Smith A, Dickson M, Aitken J, Bagg J. Contaminated dental instruments. J Hosp Infect. 2002;51(3):233-35.Miller CH, Tan CM, Beiswanger MA, Gaines DJ, Setcos JC, Palenik CJ. Cleaning dental instruments: measuring the effectiveness of an instrument washer/disinfector. Am J Dent. 2000;13(1):39-43.Bagg J, Smith AJ, Hurrel D, McHugh S, Irvine G. Pre-sterilisation cleaning of re-usable instruments in general dental practice. Br Dent J. 2007;202(9):E22.Rutala WA, Weber DJ. Disinfection and sterilization in health care facilities: an overview and current issues. Infect Dis Clin North Am.2016;30(3):609-37.Bourdon L. RP first look: new recommended practices for cleaning and care of surgical instruments. AORN J.2014;100(6):C1, C8-9.Franz A, Bristela M, Stauffer F. Reprocessing of dental instruments in washer-disinfectors: does a representative test soil exist in dentistry? GMS Krankenhhyg Interdiszip.2012;7(1):Doc13.Labnews. Stelclean Plus. Disponível em: http://www.labnews.ind.br. Acesso em 2 agosto 2018.

Kumar, Krishan, Visions of Empire. How Five Imperial Regimes Shaped the World, Princeton / Oxford 2017, Princeton University Press, XVIII u. 576 S. / Abb., £ 32,95. (Wolfgang Reinhard) Drews, Wolfram / Christian Scholl (Hrsg.), Transkulturelle Verflechtungsprozesse in der Vormoderne (Das Mittelalter. Beihefte, 3), Berlin/Boston 2016,de Gruyter, XXIII u.287 S. / Abb., € 89,95. (Jenny Rahel Oesterle) Jochum, Georg, ”Plus Ultra“ oder die Erfindung der Moderne. Zur neuzeitlichen Entgrenzung der okzidentalen Welt (Global Studies), Bielefeld 2017, transcript, 602 S. / Abb., € 44,99. (Wolfgang Reinhard) Raeymaekers, Dries / Sebastiaan Derks (Hrsg.), The Key to Power? The Culture of Access in Princely Courts, 1400–1750 (Rulers and Elites, 8), Leiden/Boston 2016, Brill, XIII u. 352 S. / Abb., € 135,00. (Andreas Pecar) Knobler, Adam, Mythology and Diplomacy in the Age of Exploration (European Expansion and Indigenous Response, 23), Leiden / Boston 2017, Brill, XI u. 151 S., € 99,00; als Brill MyBook € 25,00. (Tobias Winnerling) Muhlack, Ulrich, Renaissance und Humanismus (Enzyklopädie deutscher Geschichte, 93), Berlin / Boston 2017, de Gruyter Oldenbourg, IX u. 276 S., € 24,95 (Volker Reinhardt) Hamm, Berndt / Thomas Kaufmann (Hrsg.), Wie fromm waren die Humanisten? (Wolfenbütteler Abhandlungen zur Renaissanceforschung, 33), Wiesbaden 2016, Harrassowitz in Kommission, 359 S. / Abb., € 84,00. (Nikolaus Staubach) Auge, Oliver (Hrsg.), König, Reich und Fürsten im Mittelalter. Abschlusstagung des Greifswalder ”Principes-Projekts“. Festschrift für Karl-Heinz Spieß (Beiträge zur Geschichte der Universität Greifswald, 12), Stuttgart 2017, Steiner, 593 S. / Abb., € 94,00. (Andreas Büttner) Huang, Angela, Die Textilien des Hanseraums. Produktion und Distribution einer spätmittelalterlichen Fernhandelsware (Quellen und Darstellungen zur hansischen Geschichte. Neue Folge, 71), Köln / Weimar / Wien 2015, Böhlau, 311 S. / graph. Darst., € 40,00. (Kirsten O. Frieling) Hirbodian, Sigrid / Peter Rückert (Hrsg.), Württembergische Städte im späten Mittelalter. Herrschaft, Wirtschaft und Kultur im Vergleich (Tübinger Bausteine zur Landesgeschichte, 26), Ostfildern 2016, Thorbecke, 332 S. / Abb., € 35,00.(Stefan G. Holz) Esch, Claudia, Zwischen Institution und Individuum. Bürgerliche Handlungsspielräume im mittelalterlichen Bamberg (Stadt und Region in der Vormoderne, 4), Würzburg 2016, Ergon, 576 S. / graph. Darst., € 72,00. (Ulrich Knefelkamp) Mayer, Hans E., Von der Cour des Bourgeois zum öffentlichen Notariat. Die freiwillige Gerichtsbarkeit in den Kreuzfahrerstaaten (Monumenta Germaniae Historica. Schriften, 70), Wiesbaden 2016, Harrassowitz, XXXIV u. 526 S., € 70,00. (Wolf Zöller) Hesse, Christian, Synthese und Aufbruch. 1346–1410 (Gebhardt. Handbuch der deutschen Geschichte, 7b), Stuttgart 2017, Klett-Cotta, XLVIII u. 300 S., € 45,00. (Gabriela Signori) Frey, Stefan, Fromme feste Junker. Neuer Stadtadel im spätmittelalterlichen Zürich (Mitteilungen der Antiquarischen Gesellschaft in Zürich, 84), Zürich 2017, Chronos, 216 S. / Abb., € 43,00. (Christof Rolker) Matter-Bacon, Nicole, Städtische Ehepaare im Spätmittelalter. Verhaltensmuster und Handlungsspielräume imZürich des 15. Jahrhunderts (Wissenschaftliche Beiträge aus dem Tectum Verlag. Reihe: Geschichtswissenschaft, 30), Marburg 2016, Tectum, 412 S., € 39,95. (Elisabeth Vavra) Halter-Pernet, Colee / Felix Hammerli, Zürichs streitbarer Gelehrter im Spätmittelalter. Mit Übersetzungen aus dem Lateinischenv.Helena Müller u. Erika Egner Eid, Zürich 2017, Chronos, 446 S. / Abb., € 52,00. (Martina Wehrli-Johns) Kyle, Sarah R., Medicine and Humanism inLate Medieval Italy. The Carrara Herbal in Padua (Medicine in the Medieval Mediterranean), London / New York 2017, Routledge, XIII u. 243 S. / Abb., £ 95,00. (Klaus Bergdolt) Nodl, Martin, Das Kuttenberger Dekret von 1409. Von der Eintracht zum Konflikt der Prager Universitätsnationen. Aus dem Tschechischen übers. v. Roswitha u. Pavel Cervicek (Forschungen zur Geschichte und Kultur des östlichen Mitteleuropa, 51), Köln / Weimar / Wien 2017, Böhlau, 404 S. / Abb., € 55,00. (Blanka Zilynská) Ellermann, Julia / Dennis Hormuth / Volker Seresse (Hrsg.), Politische Kultur im frühneuzeitlichen Europa. Festschrift für Olaf Mörke zum 65. Geburtstag (Geist und Wissen, 26), Kiel 2017, Ludwig, 421 S. / Abb., € 56,80. (Wolfgang Reinhard) Horowski, Leonhard, Das Europa der Könige. Macht und Spiel an den Höfen des 17. und 18. Jahrhunderts, Reinbek 2017, Rowohlt, 1119 S. / Abb., € 39,95. (Ronald G. Asch) Rössner, Philipp R. (Hrsg.),Economic Growth and the Origins of Modern Political Economy.Economic Reasons of State, 1500–2000, London/NewYork 2016, Routledge, XII u. 317 S. / Abb., £ 95,00. (Justus Nipperdey) Burgdorf, Wolfgang (Bearb.), Die Wahlkapitulationen der römisch-deutschen Könige und Kaiser 1519–1792 (Quellen zur Geschichte des Heiligen Römischen Reiches, 1), Göttingen 2015, Vandenhoeck &amp; Ruprecht, 884 S., € 90,00. Burgdorf, Wolfgang, Protokonstitutionalismus. Die Reichsverfassung in den Wahlkapitulationen der römisch-deutschen Könige und Kaiser 1519–1792 (Schriftenreihe der Historischen Kommission bei der Bayerischen Akademie der Wissenschaften, 94), Göttingen / Bristol 2015, Vandenhoeck &amp; Ruprecht, 226 S., € 60,00. Durchhardt, Heinz (Hrsg.), Wahlkapitulationen in Europa (Schriftenreihe der Historischen Kommission bei der Bayerischen Akademie der Wissenschaften, 95), Göttingen / Bristol 2015, Vandenhoeck &amp; Ruprecht, 172 S. / Abb, € 55,00. (Alexander Denzler) Durst, Benjamin, Archive des Völkerrechts. Gedruckte Sammlungen europäischer Mächteverträge in der Frühen Neuzeit (Colloquia Augustana, 34), Berlin/Boston 2016, de Gruyter Oldenbourg, 494 S. / Abb., € 79,95. (Anuschka Tischer) Krischer, André, Die Macht des Verfahrens. Englische Hochverratsprozesse 1554–1848 (Verhandeln, Verfahren, Entscheiden, 3), Münster 2017, Aschendorff, VII u. 720 S. / Abb., € 79,00. (Ronald G. Asch) Elmer, Peter, Witchcraft, Witch-Hunting, and Politics in Early Modern England, Oxford / New York 2016, Oxford University Press, X u. 369 S., £ 65,00. (Gerd Schwerhoff) Mentzer, Raymond A. / Betrand Van Ruymbeke (Hrsg.), A Companion to the Huguenots (Brill’s Companions to the Christian Tradition, 68), Leiden/Boston 2016, Brill, XV u. 481 S. / Abb., € 229,00; als Brill MyBook € 25,00. (Ulrich Niggemann) Cevolini, Alberto (Hrsg.), Forgetting Machines: Knowledge Management Evolution in Early Modern Europe (Library of the Written Word, 53; The Handpress World, 40), Leiden / Boston 2016, Brill, XI u. 389 S., € 154,00. (Martin Gierl) Freist, Dagmar / Susanne Lachenicht (Hrsg.), Connecting Worlds and People. Early Modern Diasporas, Abingdon / New York 2017, Routledge, XIII u. 149 S./ graph. Darst., £ 95,00. (Thomas Dorfner) Boer, Wietsede / Karl A. E. Enenkel / Walter S. Melion(Hrsg.), Jesuit Image Theory (Intersections, 45), Leiden / Boston 2016, Brill, XIX u. 497 S. / Abb., € 172,00. (Dominik Sieber) Abreu, Laurinda, The Political and Social Dynamics of Poverty, Poor Relief and Health Care in Early-Modern Portugal (The History of Medicine in Context), London / New York 2016, Routledge, VI u. 302 S. / graph. Darst., £ 110,00. (Robert Jütte) Häberlein, Mark (Hrsg.), Sprachmeister. Sozial- und Kulturgeschichte eines prekären Berufsstands (Schriften der Matthias-Kramer-Gesellschaft zur Erforschung der Geschichte des Fremdsprachenerwerbs und der Mehrsprachigkeit, 1), Bamberg 2015, University of Bamberg Press, 218 S. / Abb., € 18,00. (Michael Schaich) Handley, Sasha, Sleep in Early Modern England, New Haven / London 2016, Yale University Press, XII u. 280 S. / Abb., $ 65,00. (Marion Kintzinger) Nieden, Marcel (Hrsg.), Ketzer, Held und Prediger. Martin Luther im Gedächtnis der Deutschen, Darmstadt 2017, Lambert Schneider, 248 S. / Abb., € 49,95. Rößler, Hole (Hrsg.), Luthermania. Ansichten einer Kultfigur (Ausstellungskataloge der Herzog August Bibliothek, 99), Wiesbaden 2017, Harrassowitz in Kommission, 407 S. / Abb., € 39,80. (Eike Wolgast) Eser, Thomas / Stephanie Armer (Hrsg.), Luther, Kolumbus und die Folgen. Welt im Wandel 1500–1600. Ausstellung im Germanischen Nationalmuseum, Nürnberg vom 13. Juli bis 12. November 2017, Nürnberg 2017, Verlag des Germanischen Nationalmuseums, 312 S. / Abb., € 36,00.(Heinz Schilling) Biagioni, Mario, The Radical Reformation and the Making of Modern Europe. A Lasting Heritage (Studies in Medieval and Reformation Traditions, 207), Leiden / Boston 2017, Brill, XI u. 180 S., € 108,00. (Hans-Jürgen Goertz) Peters, Christian, Vom Humanismus zum Täuferreich. Der Weg des Bernhard Rothmann (Refo500 Academic Studies, 38), Göttingen / Bristol 2017, Vandenhoeck &amp; Ruprecht, 201 S. / Abb., € 90,00. (James M. Stayer) Bräuer, Siegfried / Günther Vogler / Thomas Müntzer, Neu Ordnung machen in der Welt. Eine Biographie, Gütersloh 2016, Gütersloher Verlagshaus, 496 S./ Abb., € 58,00. (Ulrich Bubenheimer) Müntzer, Thomas, Manuskripte und Notizen, hrsg. v. Armin Kohnle/Eike Wolgast unter Mitarbeit v. Vasily Arslanov / Alexander Bartmuß / Christine Haustein (Thomas-Müntzer-Ausgabe. Kritische Gesamtausgabe, 1), Leipzig 2017, Sächsische Akademie der Wissenschaftenzu Leipzig/Evangelische Verlagsanstalt inKommission, XXIII u. 546 S., € 58,00. (Cornel Zwierlein) Selderhuis, Herman J. / Arnold Huijgen (Hrsg.), Calvinus Pastor Ecclesiae. Papers of the Eleventh International Congress on Calvin Research (Reformed Historical Theology, 39), Göttingen / Bristol 2016, Vandenhoeck &amp; Ruprecht, 467 S., € 120,00. (Iris Fleßenkämper) McCallum, John, Scotland’s LongReformation.NewPerspectives on Scottish Religion, c. 1500–c. 1600 (St AndrewsStudies in Reformation History), Leiden/Boston 2016, Brill, XI u. 230 S. / Abb., € 110,00. (Martin Foerster) Toenjes, Christopher, Islam, the Turks and the Making of the Reformation. The History of the Ottoman Empire in John Foxe’s Acts and Monuments, Frankfurt a. M. [u. a.] 2016, Lang, XVI u. 447 S. / Abb., € 74,70. (Stefan Hanß) GarcÍa-Arenal (Hrsg.), After Conversion. Iberia and the Emergence of Modernity (Catholic Christendom, 1300–1700), Leiden / Boston 2016, Brill, XII u. 463 S. / Abb., € 181,00; als eBook open access. Norton, Claire, ConversionandIslam in the EarlyModernMediterranean.The Lure of the Other (Routledge Research in Early Modern History), London / New York 2017, Routledge, X u. 222 S. / Abb., £ 110,00; als eBook £ 35,99. (Christian Windler) Graf, Tobias P., The Sultan’s Renegades. Christian-European Converts to Islam and the Making of the Ottoman Elite,1575–1610, Oxford 2017, Oxford University Press, XX u. 261 S. / Abb., £ 65,00. (Arkadiusz Blaszczyk) Hans Dernschwam’s Tagebuch einer Reise nach Konstantinopel und Kleinasien (1553/55), hrsg. v. Franz Babinger, ins Neuhochdeutsche übers. v. Jörg Riecke, Berlin 2014, Duncker &amp; Humblot, XXXVII u. 300 S. / Abb., € 69,90. (Mathis Leibetseder) Comerford, Kathleen M., Jesuit Foundations and Medici Power, 1532–1621 (Jesuit Studies, 7), Leiden / Boston 2017, Brill, XVI u. 316 S. / graph. Darst., € 142,00. (Fabian Fechner) Nicolaus von Amsdorff, Ausgewählte Schriften der Jahre 1550 bis 1562 aus der ehemaligen Eisenacher Ministerialbibliothek, hrsg. v. Hagen Jäger (Leucorea-Studien zur Geschichte der Reformation und der Lutherischen Orthodoxie, 32), Leipzig 2017, Evangelische Verlagsanstalt, 284 S., € 48,00. (Volker Leppin) Piltz, Eric / Gerd Schwerhoff (Hrsg.), Gottlosigkeit und Eigensinn. Religiöse Devianz im konfessionellen Zeitalter (Zeitschrift für Historische Forschung. Beiheft, 51), Berlin 2015, Duncker &amp; Humblot, 530 S. / Abb., € 69,90. (Martin Scheutz) Schmidt-Biggemann, Wilhelm / Friedrich Vollhardt (Hrsg.), Ideengeschichte um 1600. Konstellationen zwischen Schulmetaphysik, Konfessionalisierung und hermetischer Spekulation (Problemata, 158), Stuttgart-Bad Cannstatt 2017, Frommann-Holzboog, 338 S. / Abb., € 68,00. (Tobias Winnerling) Friedrich, Markus / Sascha Salatowsky / Luise Schorn-Schütte (Hrsg.), Konfession, Politik und Gelehrsamkeit. Der Jenaer Theologe Johann Gerhard (1582–1637) im Kontext seiner Zeit (Gothaer Forschungen zur Frühen Neuzeit, 11), Stuttgart 2017, Steiner, 280 S., € 52,00. (Martin Gierl) Schleinert, Dirk / Monika Schneikart (Hrsg.), Zwischen Thronsaal und Frawenzimmer. Handlungsfelder pommerscher Fürstinnen um 1600 (Veröffentlichungen der Historischen Kommission für Pommern. Reihe V: Forschungen zur pommerschen Geschichte, 50), Köln / Weimar / Wien 2017, Böhlau, 402 S. / Abb., € 55,00. (Katrin Keller) Wareing, John, Indentured Migration and the Servant Trade from London to America, 1618–1718. „There is Great Want of Servants“, Oxford / New York 2017, Oxford University Press, VIII u. 298 S. / Abb., £ 75,00. (Mark Häberlein) May, Niels F., Zwischen fürstlicher Repräsentation und adliger Statuspolitik. Das Kongresszeremoniell bei den westfälischen Friedensverhandlungen (Beihefte der Francia, 82), Ostfildern 2016, Thorbecke, 284 S., € 42,00. (Anuschka Tischer) Haupt, Herbert, Ein Herr von Stand und Würde. Fürst Johann Adam Andreas von Liechtenstein (1657–1712). Mosaiksteine eines Lebens, Köln / Weimar / Wien 2016, Böhlau, 389 S. / Abb., € 47,00. (Thomas Winkelbauer) Homa, Bernhard, Die Tübinger Philosophische Fakultät 1652–1752. Institution – Disziplinen – Lehrkräfte (Contubernium, 85), Stuttgart 2016, Steiner, 428 S. / 1 CDROM, € 69,00. (Martin Gierl) Windler, Christian (Hrsg.), Kongressorte der Frühen Neuzeit im europäischen Vergleich. Der Friede von Baden (1714), Köln/Weimar/Wien 2016, Böhlau, 303 S. / Abb., € 19,90. (Regina Dauser) Pecar, Andreas / Holger Zaunstöck / Thomas Müller-Bahlke (Hrsg.), Wie pietistisch kann Adel sein? Hallescher Pietismus und Reichsadel im 18. Jahrhundert (Quellen und Forschungen zur Geschichte Sachsen-Anhalts, 10), Halle a. d. S. 2016, Mitteldeutscher Verlag, 176 S. / Abb., € 25,00. (Martin Gierl) Eißner, Daniel, Erweckte Handwerker im Umfeld des Pietismus. Zur religiösen Selbstermächtigung in der Frühen Neuzeit (Hallesche Forschungen, 43), Halle a. d. S. / Wiesbaden 2016, Verlag der Franckeschen Stiftungen / Harrassowitz in Kommission, IX u. 384 S., € 52,00. (Martin Gierl) Black, Jeremy, British Politics and Foreign Policy, 1744–57. Mid-Century Crisis, Farnham / Burlington 2015, Ashgate, XIV u. 267 S., £ 70,00. (Michael Schaich) Stobart, Jon / Mark Rothery (Hrsg.), Consumption and the Country House, Oxford / New York 2016, Oxford University Press, X u. 304 S. / Abb., £ 65,00. (Michael Maurer) Diest, Johann von, Wirtschaftspolitik und Lobbyismus im 18. Jahrhundert. Eine quellenbasierte Neubewertung der wechselseitigen Einflussnahme von Obrigkeit und Wirtschaft in Brandenburg-Preußen und Kurhannover (Herrschaft und soziale Systeme in der Frühen Neuzeit, 23), Göttingen 2016, V&amp;R unipress, 392 S., € 55,00. (Justus Nipperdey) Kech, Kerstin, Hofhaltung und Hofzeremoniell der Bamberger Fürstbischöfe in der Spätphase des Alten Reichs (Stadt und Region in der Vormoderne, 6; Veröffentlichungen des Stadtarchivs Bamberg, 28), Würzburg 2016, Ergon, 430 S. / Abb., € 58,00. (Bettina Braun) Fischer, Ole (Hrsg.), Aufgeklärte Lebenswelten (Studien zur Wirtschafts- und Sozialgeschichte Schleswig-Holsteins, 54), Stuttgart 2016, Steiner, 242 S., € 29,00. (Dominik Hünniger) Rheinheimer, Martin, Ipke und Angens. Die Welt eines nordfriesischen Schiffers und seiner Frau (1787–1801) (Studien zur Wirtschafts- und Sozialgeschichte Schleswig-Holsteins, 55), Stuttgart 2016, Steiner, 161 S. / Abb., € 29,90. (Jann M. Witt) Maurer, Michael, Wilhelm von Humboldt. Ein Leben als Werk, Köln/Weimar/Wien 2016, Böhlau, 310 S. / Abb., € 25,00. (Jann M. Witt)