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Dissertations / Theses on the topic 'Viral infection'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 July 2025

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1

Nikin-Beers, Ryan Patrick. "Immunoepidemiological Modeling of Dengue Viral Infection." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/82924.

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Dengue viral infection is a mosquito-borne disease with four distinct strains, where the interactions between these strains have implications on the severity of the disease outcomes. The two competing hypotheses for the increased severity during secondary infections are antibody dependent enhancement and original antigenic sin. Antibody dependent enhancement suggests that long-lived antibodies from primary infection remain during secondary infection but do not neutralize the virus. Original antigenic sin proposes that T cells specific to primary infection dominate cellular immune responses dur

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2

Nikin-Beers, Ryan Patrick. "Mathematical Modeling of Dengue Viral Infection." Thesis, Virginia Tech, 2014. http://hdl.handle.net/10919/48594.

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In recent years, dengue viral infection has become one of the most widely-spread mosquito-borne diseases in the world, with an estimated 50-100 million cases annually, resulting in 500,000 hospitalizations. Due to the nature of the immune response to each of the four serotypes of dengue virus, secondary infections of dengue put patients at higher risk for more severe infection as opposed to primary infections. The current hypothesis for this phenomenon is antibody-dependent enhancement, where strain-specific antibodies from the primary infection enhance infection by a heterologous serotype. To

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3

James, Katherine Louise. "Viral genetics of HIV-2 infection." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:68ba022d-62e4-4cb1-8032-085ea5240b98.

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HIV-2 is a contemporary human retrovirus with the majority of infections localised to West Africa. Both HIV-1 and HIV-2 are able to cause AIDS; however, in contrast to HIV-1 infection, a common outcome following HIV-2 infection (&Tilde; 37&percnt; of patients in this study cohort) is long-term non-progression (LTNP), where patients remain aviraemic and asymptomatic in the absence of treatment, often for decades. HIV-1 and HIV-2 both arose following zoonotic transmission of SIVs from non-human primates at around the beginning of the 20<sup>th</sup> century and when patients develop AIDS caused

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4

Pruikkonen, H. (Hannele). "Viral infection induced respiratory distress in childhood." Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526207919.

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Abstract Dyspnoea associated with respiratory infection is a common symptom in infancy and early childhood. Inspiratory stridor is the main symptom in cases of croup and expiratory wheezing in cases of bronchiolitis, obstructive bronchitis and acute asthma exacerbations. Dyspnoea associated with respiratory infection is a common cause of emergency department visits and unplanned hospital admissions among infants and preschool children. The assessment of dyspnea associated with acute childhood respiratory infection is largely subjective, and evidence regarding the severity of acute dyspnoea is

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5

Howat, Tom James. "Spatial dynamics of in vitro viral infection." Thesis, University of Cambridge, 2007. https://www.repository.cam.ac.uk/handle/1810/252041.

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Despite the importance of the IFNs in viral infections, many questions about the dynamics of IFN production and activity remain unanswered. Addressing these questions forms the first half of this thesis. It begins with an introduction to innate immunity, and a review of existing research. Focus then falls upon a simple experimental system: the <i>in vitro</i> infection of cell monolayers by Herpes simplex virus and the resulting IFN response. A stochastic spatial model of viral infection and consequent IFN production and activity is constructed. Using this model, simulations of infections unde

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6

Christie, John Michael Landale. "Viral persistence in hepatitis C virus infection." Thesis, University of Southampton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268465.

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7

Zhang, Lei Centre for Vascular Research Faculty of Medicine UNSW. "Understanding viral-immune dynamics in HIV infection." Awarded by:University of New South Wales. Centre for Vascular Research, 2005. http://handle.unsw.edu.au/1959.4/23372.

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The HIV epidemic has caused a health crisis globally. Using mathematical and statistical tools, we have analysed and modelled data from animal models of HIV, HSV and influenza virus, in order to understand the role of neutralising antibodies (nAbs), CD4+ T cells, CTLs and APCs in HIV infection and the implications of this for HIV vaccine design. Our analysis suggests that antibody and CTL responses confer protection at different stages of HIV infection. Passive antibodies confer protection against SHIV89.6PD infection by either neutralising the initial viral inoculum or reducing the acute vira

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8

Li, Wei Beck Melinda A. "Nutritionally-induced oxidative stress and viral infection." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,523.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Nutrition." Discipline: Nutrition; Department/School: Public Health.

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9

Lobbermann, Jens. "Regulation of immunity during viral lung infection." Thesis, Imperial College London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.544288.

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10

Stevens, Kim. "Multiplicity of viral infection in brown algae." Thesis, University of Plymouth, 2014. http://hdl.handle.net/10026.1/3156.

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Brown algae are important primary producers and habitat formers in coastal environments and are believed to have evolved multicellularity independently of the other eukaryotes. The phaeoviruses that infect them form a stable lysogenic relationship with their host via genome integration, but have only been extensively studied in two genera: Ectocarpus and Feldmannia. In this study I aim to improve our understanding of the genetic diversity, host range and distribution of phaeoviruses. Sequencing and phylogenetic analysis of amplified fragments of three core phaeoviral genes (encoding major caps

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11

Barasheed, Osamah Abdullah A. "Prevention of respiratory viral infection among Hajj pilgrims." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23506.

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Hajj is one of the five basic tenets of Islam. Every practicing, financially and physically capable, Muslim is required to perform Hajj at least once in his/her lifetime. Each year up to three million people from more than 180 countries assemble in Mecca, Saudi Arabia, to perform Hajj pilgrimage. Severe crowding, shared accommodation, poor personal hygiene, and environmental pollution at Hajj may collectively lead to increased transmission of respiratory viruses. Influenza-like illness (ILI) is one of the most common medical presentations to primary care, mostly due to viral infection, in whic

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12

Manley, Grace C. A. "The roles of DUSPs in respiratory viral infection." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/19257/.

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13

Karrer, Urs. "Mouse cytomegalovirus infection as a model for persistent viral infections in mice and humans." Thesis, Open University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422034.

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14

Caney, Sarah Madeline Amanda. "Mucosal immunopathogenesis of feline immunodeficiency virus infection." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341499.

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15

Hussain, Imran Raza. "The immunobiology of respiratory syncytial virus infection." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289569.

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16

Eleftheriou, Androulla Anastasiou. "Viral infection among Thalassaemia major patients with special reference to Hepatitis C virus infection." Thesis, University of London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265118.

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17

Dhenni, Rama B. S. "Role of Granzyme B in the Susceptibility to Secondary Bacterial Infection after Viral Infection." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1460446984.

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18

Leong, Iona Tuling. "Oral non-Hodgkin's lymphomas and Epstein-Barr viral infection." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0028/MQ34046.pdf.

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19

Dovigi, Allan Webster-Cyriaque Jennifer. "HIV salivary gland disease a role for viral infection /." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2005. http://dc.lib.unc.edu/u?/etd,297.

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Thesis (M.S.)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Master of Science in the Department of Oral and Maxillofacial Pathology School of Dentistry." Discipline: Oral and Maxillofacial Pathology; Department/School: Dentistry.

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20

Karlsson, Annika C. "Viral dynamics and evolution following primary HIV-1 infection /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4558-6/.

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21

Huang, Kenneth Hsing-Chung. "Immune correlates of viral control in chronic HIV infection." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111908.

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There are currently an estimated 33.2 million people living with human immunodeficiency virus (HIV) worldwide. For these individuals, long-term use of combination antiretroviral therapy (cART) is not feasible for a variety of reasons including major adverse complications, multi-drug resistance, poor adherence, and high cost. Hence, development of novel therapeutic strategies that can reduce the life-long dependency on cART is highly desired. In order to develop effective therapeutic strategies such as a therapeutic vaccine, we need to have a greater understanding of the immune correlates of vi

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22

Gramoustianou, Evangelia Sophia. "Viral and host gene expression during human cytomegalovirus infection." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1444419/.

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HCMV infection is usually asymptomatic in immunocompetent hosts, but serious disease can occur in immunocompromised individuals and in congenitally infected newborns. The importance of virus fitness determinations became evident in 1976, when it was proposed that the infecting strain of HCMV is important for clinical outcome, along with the intensity and duration of viral replication. HCMV strains exhibit different levels of virulence in vivo, depending on their passage history in cell culture. High and low passage HCMV strains exhibit tropism differences in vitro, suggesting that different ti

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23

Jorfi, Samireh. "The role of microvesicles in cancer and viral infection." Thesis, London Metropolitan University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590129.

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Microvesicles are shed constitutively, or upon activation from both normal and malignant cells. Although recent studies have reported various nonlytic virus release mechanisms, this mode of virus transmission to secondary sites of infection has remained unclear. This study identified that Coxsackie virus B1 (CVB1) entry into HeLa cells results in apoptosis and production of virus-induced apoptotic microvesicles (vaMVs) by infected cells. Flow cytometery and fluorescence microscopy data illustrated that these vaMVs carry and disseminate CVB1 virions to new host cells via a non lytic MV-to-cell

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24

Dillon, Amanda Louise. "Protozoan grazing and viral infection of freshwater synechococcus species." Thesis, Lancaster University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536035.

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25

Jones, Joshua David. "Found in translation : tracking the ribosome during viral infection." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709233.

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26

Lissauer, Samantha Mary. "Modelling hepatitis C viral host interaction and co-infection." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8774/.

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Hepatitis C Virus (HCV) is a clinically important infection that leads to chronic liver disease and Human Immunodeficiency Virus (HIV) co-infected patients have more rapid progression to severe liver disease and show higher rates of HCV vertical transmission. Hepatocytes are a highly differentiated cell type and support low level HCV replication. Most studies of the viral life cycle use de-differentiated hepatoma cell lines, which are highly permissive. The mechanism behind this difference is poorly understood. We show that dimethylsulfoxide (DMSO) differentiated Huh-7 cells have a 100-fold re

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27

Kauffman, Anne Kathryn Marie. "Demographics of lytic viral infection of coastal ocean vibrio." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/90046.

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Thesis: Ph. D., Joint Program in Biological Oceanography (Massachusetts Institute of Technology, Department of Civil and Environmental Engineering; and the Woods Hole Oceanographic Institution), 2014.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Viral predation on bacteria in the ocean liberates carbon from the particulate fraction, where it is accessible to higher trophic levels, and redirects it to the dissolved fraction, where it supports microbial growth. Although viruses are highly abundant in the ocean little is known about how their interactions wi

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28

Al-Juboori, M. R. "Viral and parasitic diseases in patients with HIV infection." Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/32230.

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The aim of our research was to analyze the dependence of clinical manifestations of infections with viral and parasitic etiology on the background of HIV infection from the level of CD4-lymphocytes. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/32230

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29

Lin, Adora A. "The CD4+ T cell response to CNS viral infection." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1235330516.

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30

Moissiard, Guillaume. "Induction, suppression, amplification of RNA silencing during viral infection." Université Louis Pasteur (Strasbourg) (1971-2008), 2007. http://www.theses.fr/2007STR13023.

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L’ARN silencing est un mécanisme de régulation négative de l’expression des gènes par des interactions entre molécules d’ARN. Un ARN double-brin est découpé par Dicer en “short-interfering (si)RNA” de 21 à 24-nt incorporant un “RNA-Induced Silencing Complex”, pour guider le clivage d’ARNm cible de manière séquence spécifique. Le silencing joue un rôle important dans la lutte antivirale chez les plantes. De plus, la plupart des phytovirus produisent des protéines suppresseurs de silencing. Le silencing peut être amplifié par l’activité d’ARN-dépendante ARN polymérases (RDR) cellulaires. Nous av

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31

Marques, Mariana Campos. "Cellular responses to viral infection : proteostasis and innate immunity." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22054.

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Mestrado em Biomedicina Molecular<br>Viruses are small opportunistic infectious agents. Virus entry, replication and assembly are dynamic and coordinated processes that require precise interactions with host components, often with cellular organelles. Hence, we proposed to study two different viruses affecting two distinct cellular surveillance mechanisms: Human Cytomegalovirus (HCMV) and Influenza A Virus (IAV) influence on the innate immune response and proteostasis, respectively. HCMV might be associated with additional long-term health consequences in human due to its ability to establish

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32

Hauler, Felix. "The ATPase VCP in viral infection and antiviral immunity." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.707973.

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33

Falconer, Karolin. "HIV-1/HCV co-infection immunity and viral dynamics /." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-762-7/.

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34

Cootes, Taylor Ann. "Dietary regulation of the host response to viral infection." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/28614.

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Host factors, such as genetics and aging, are known to regulate the severity of influenza. However, the role of environmental factors in the viral infection remains poorly defined. By altering individual nutrition components or energy density, animal studies have clearly demonstrated that diet modulates the outcome to influenza in mice. However, it remains unclear whether energy-balanced diets, known to be sufficient in supporting the health of naïve animals, are adequate in mediating the survival of the infected host. This thesis work was set to investigate whether diet quality, independent o

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35

Donahue, Daniel. "The role of viral reservoirs in HIV-1 infection." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=119565.

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The major source of virus production during human immunodeficiency virus type 1 (HIV-1) infection is activated CD4 T-cells, although infection of some other cell types can also contribute to virus production. A viral reservoir is either a cell type or an anatomical site whose properties can result in the persistence of infectious virus for a longer time period than the primary source of virus production, and several different HIV-1 reservoirs are known to exist. The work presented in this thesis examines three different aspects of viral reservoirs in HIV-1 infection. The first part (Chapter 2)

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36

Christiaansen, Allison Fae. "T cell regulation of acute and chronic viral infection." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/6076.

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A balanced immune response is required to mediate clearance of a virus infection without immune-mediated disease. CD4 and CD8 T cells are capable of both exerting antiviral effector functions and regulating the immune response. The regulatory T cell (Treg) subset of CD4 T cells helps to modulate immune activation and inflammation. During respiratory syncytial virus (RSV) infection in mice, conventional CD4 T-cell-mediated cytokine production has been shown to contribute to immune-mediated pathology.

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37

CORTESE, MARIA FRANCESCA. "HIV and HBV infection as models of viral DNA integration and mechanisms of viral-associated carcinogenesis." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2015. http://hdl.handle.net/2108/203036.

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My PhD was focused on two viruses, both responsible of persistent infection: HIV and HBV. The two viruses show high worldwide prevalence and both are associated with high morbidity and mortality. HIV establishes a persistent infection through different mechanisms, first of all with the integration of its DNA into the host genome, thus forming the provirus. However, a consistent part of the viral DNA within the infected cells is unintegrated (circular or not). The project following presented aims to analyse the kinetic of viral replication (measured as p24 production) and HIV DNA i

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38

Yao, Felix Caspar. "Investigation on the risk of viral infection in musculoskeletal grafts." University of Western Australia. School of Surgery, 2010. http://theses.library.uwa.edu.au/adt-WU2010.0068.

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[Truncated abstract] Around 50,000 hip and knee replacements are performed every year in Australia and this number has been increasing by around 13% annually since 1998 (Transplantation Society 2006). The incidence and number of revision surgery has increased by a similar proportion. Autogenous bone or allograft is still the gold standard grafting material and is currently used in a variety of reconstructive surgical procedures. The use of any allograft material carries with it the risk of transfer of disease from donor to recipient. These tissues can transmit the same viral and bacterial infe

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39

Suhartha, Nina Aryani. "Regulation of α4β7 on naïve T cells upon viral infection". Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-164321.

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The elimination of virus-infected cells to block viral spread is substantially conveyed by effector CD8+ T cells. Trafficking of naïve T cells into the lymph node is a crucial step for their activation to effector T cells. The entry into the lymph nodes is mediated by several cell adhesion molecules that are highly specific for given lymph nodes. For the ingress into the gut-associated lymphoid tissue (GALT) such as mesenteric lymph nodes and Peyer’s patches, the integrin α4β7 is the major homing receptor that interacts with its main ligand MAdCAM-1. On naïve T cells, α4β7 is expressed a

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40

Eddleston, Michael Philip. "Reactive astrocytosis after viral infection of the central nervous system." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336610.

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Ribeiro, Ruy Miguel. "Models of viral diversity and disease development in HIV infection." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302403.

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Graham, Christine Marian. "Anti-viral immunity : helper T cells in influenza virus infection." Thesis, Oxford Brookes University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444320.

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Katafigiotis, Sokratis. "Regulation of viral gene expression during infection with enteric viruses." Thesis, University of Nottingham, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495601.

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In this study two enteric viruses, poliovirus and adenovirus type 40, were used to investigate virus - host cell interactions in the gastrointestinal environment. Human enteric adenoviruses have been previously shown to be sensitive to IFN-treatment of cells and a STAT-deficient cell line allows improved growth of enteric adenovirus type 40. Two adenoviral gene products, the virus-associated RNA (VA RNA) and the El A, have been previously shown to be responsible for viral countermeasures against IFN actions in the host cell.

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Lee, Debbie Ching Ping. "Regulation of immune responses and viral persistence in RSV infection." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.503821.

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Razvi, Enal Shahid. "T Lymphocyte Apoptosis and Memory in Viral Infection: A Dissertation." eScholarship@UMMS, 1994. http://escholarship.umassmed.edu/gsbs_diss/263.

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Acute viral infections in humans and mice induce T lymphocyte responses which mediate viral clearance and result in the establishment of immunological memory. The course of an immune response to acute viral infection is associated with an immune deficiency in the lymphocyte compartment. This is usually characterized by the inability of lymphocytes to productively respond to mitogen or recall antigen. This thesis examined the acute lymphocytic choriomeningitis virus (LCMV) infection of the mouse and showed that T lymphocytes isolated from acutely LCMV-infected mice underwent activation-induced

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McManus, T. E. "Viral infection and associated inflammation in chronic obstructive pulmonary disease." Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426766.

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Піддубна, Анна Іванівна, Анна Ивановна Поддубная, Anna Ivanivna Piddubna, Алекс Магуфва, Алекс Магуфва, and Alex Magufwa. "Clinical presentations of viral and parasitic diseases in HIV infection." Thesis, Одеський національний медичний університет, 2012. http://essuir.sumdu.edu.ua/handle/123456789/26618.

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Представлений аналіз залежності клінічних проявів інфекцій вірусної і паразитарної етіології на тлі ВІЛ-інфекції від рівня CD4-лімфоцитів. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/26618<br>Представлен анализ зависимости клинических проявлений инфекций вирусной и паразитарной этиологии на фоне ВИЧ-инфекции от уровня CD4-лимфоцитов. При цитировании документа, используйте ссылку http://essuir.sumdu.edu.ua/handle/123456789/26618<br>Represented the analysis of dependence of clinical manifestations of infections with viral and parasitic etiology o

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48

Wen, Li. "Immune responses to vaginal viral infection in a mouse model." Thesis, The University of Sydney, 1998. https://hdl.handle.net/2123/27666.

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Viral infection in the female reproductive tract is a global health problem, with high morbidity and mortality worldwide. However, immune protection of the female reproductive tract against virus infection is poorly understood. The aim of the study described in this thesis was to investigate the immune responses to vaginal West Nile virus (WNV) infection in an experimental mouse model, in an attempt to characterize the immune mechanisms involved in protecting the host against viral infection in the female genital tract. WNV is a neurotropic flavivirus which can infect both humans and animals,

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49

Plume, Jeffrey Michael. "The role of viral strain in a congenital brain infection." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/2130.

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Lymphocytic Choriomeningitis Virus (LCMV) is a common arenavirus and natural murine pathogen that causes congenital neurodevelopmental disease in humans. Exposure to the virus in utero often results in severe and permanent damage the fetal brain and eyes. While usually severe, symptoms vary from case to case. Little is known about the pathological mechanism of congenital LCMV disease. Animal models of congenital LCMV infections suggest that timing of infection during gestation may influence disease outcomes; however, time alone cannot explain all of the variation observed in humans. Another po

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Lagache, Thibault. "Modeling the early steps of viral infection : a stochastic approach." Paris 6, 2009. http://www.theses.fr/2009PA066470.

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