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Dissertations / Theses on the topic 'Viral variants'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Hallett, Rachel Louise. "Molecular epidemiological studies of defined variants of hepatitis B and TT viruses." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251923.

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2

Saade, Carla. "Immune response against SARS-CoV-2 : impact of viral variants, vaccination, and protection against reinfection." Electronic Thesis or Diss., Lyon 1, 2024. http://www.theses.fr/2024LYO10271.

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La pandémie COVID-19 a posé des défis majeurs aux systèmes de santé mondiaux, notamment en raison de la capacité du SARS-CoV-2 à acquérir des mutations. Cela a entraîné l'émergence séquentielle de variants préoccupants (VOCs de l’anglais Variants of concern) tels que Alpha, Beta, Delta, et désormais Omicron qui circule sous forme de sous-variants successifs (BA.1, JN.1, KP.3). Ces VOCs soulèvent des questions sur leur capacité à échapper à la réponse immunitaire induite par une infection et/ou une vaccination. Alors que les campagnes de vaccination se poursuivent, il est crucial d'évaluer comm
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3

Hulot, Sandrine. "Reconnaissance de variants d'un épitope viral par des lymphocytes T CD8+ induits par la vaccination de singes rhésus." Phd thesis, Conservatoire national des arts et metiers - CNAM, 2010. http://tel.archives-ouvertes.fr/tel-00598370.

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La diversité génétique du virus de l'immunodéficience humaine, le VIH-1 responsable de la pandémie du SIDA, représente un challenge dans le développement d'un vaccin qui doit conférer une protection contre différentes formes du virus pour être efficace. L'identification de populations de lymphocytes T CD8+ (CTL) capables de reconnaître des variants peptidiques d'un épitope est donc une étape importante. Dans le modèle singes rhésus, j'ai montré en utilisant des tétramères spécifiques de 9 variants peptidiques d'un épitope qu'une même population de CTL générés par la vaccination, peut reconnaît
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4

Barbosa, Filho Roberto Alexandre Alves. "Clonagem, sequenciamento e estudos moleculares do genoma de HPV 16 isolado na Amazônia." Universidade Federal do Amazonas, 2010. http://tede.ufam.edu.br/handle/tede/3630.

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Made available in DSpace on 2015-04-22T22:12:45Z (GMT). No. of bitstreams: 1 Roberto Alexandre.pdf: 1763581 bytes, checksum: c0c0eb448d286d60be56fecd5eb291e0 (MD5) Previous issue date: 2010-08-03<br>CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The Human papillomavirus is responsible for lesions in the oral mucosa, anal and urogenital tract of male and female, transmitted by direct or indirect contact with infected skin or through sexual intercourse. In women these infections can progress to cervical cancer, which is estimated incidence for the Northern region in 2
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5

Labaille, Jennifer. "Conception d'un vaccin recombinant contre la maladie de Marek d'après l'étude de la dynamique des populations de variants du vaccin CV1988/RISPENS." Thesis, Tours, 2013. http://www.theses.fr/2013TOUR4014.

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Le Gallid herpesvirus 2 (GaHV-2), responsable de lymphomes T du poulet, est contrôlé par le vaccin CVI988/Rispens. Mes travaux de thèse ont montré que le vaccin était composé, au contraire des souches virulentes, d’une population dynamique de variants viraux majoritairement délétés de la région promotrice et d’une partie variable de l’extrémité 5’ du gène LAT codant des microARN et associé à la latence virale. Dans une approche vaccinale, un virus recombinant correspondant à l’un des variants majoritaires du vaccin CVI988/Rispens a été généré à partir d’une souche GaHV-2 hypervirulente, clonée
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6

Hagag, Ibrahim [Verfasser]. "Marek’s disease virus: from novel viral interleukin-8 (vIL-8) splice variants to inhibition with CRISPR/Cas9 / Ibrahim Hagag." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1218076895/34.

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7

Kishko, Michael G. "Molecular and Functional Properties of Transmitted HIV-1 Envelope Variants: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/519.

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In 2008 the Nobel Prize in Physiology or Medicine was awarded to the co-discoverers of the Human Immunodeficiency Virus Type 1 (HIV-1), the causative agent of Acquired Immunodeficiency Syndrome (AIDS). This award acknowledged the enormous worldwide impact of the HIV-1/AIDS pandemic and the importance of research aimed at halting its spread. Since the syndrome was first recognized, 25 million people have succumbed to AIDS and over 33 million are currently infected with HIV-1 (www.unaids.org). The most effective strategy for ending the pandemic is the creation of a prophylactic vaccine. Yet, to
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8

Chenane, Houssem Eddine. "Étude de marqueurs sérologiques et génomiques des virus respiratoires SARS-CoV-2 et VRS." Electronic Thesis or Diss., Université Paris Cité, 2025. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=7854&f=76741.

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Depuis son émergence en 2019, le SARS-CoV-2 a engendré une pandémie mondiale sans précédent, bouleversant les systèmes de santé et provoquant une crise sanitaire majeure. Le diagnostic de la COVID-19 repose principalement sur la détection de l'ARN viral par RT-PCR nasopharyngée, mais la quantification de l'antigène N dans le sérum (antigénémie N) pourrait offrir une alternative précieuse en tant que marqueur pronostique de la sévérité de la maladie. Par ailleurs, l'apparition continue de nouveaux variants, porteurs de mutations sur la protéine de spicule S, a amplifié les défis posés par la pa
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9

Fins, Ivo Joel Salgueiro. "Molecular surveillance of parvoviruses circulating in cats in the United Kingdom." Master's thesis, Universidade de Évora, 2018. http://hdl.handle.net/10174/23095.

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This dissertation was developed under the Curricular Traineeship scope, which took place at the University of Nottingham, between July 2016 and April 2017. Feline panleukopenia virus (FPV) and canine parvovirus (CPV), two closely related viruses, are known to cause acute enteritis in companion animals. Cats may be infected by strains of both viruses. Population-based surveillance studies have been lacking. This study investigated the prevalence of parvoviruses in a cross-sectional survey of clinically-healthy cats housed within 13 shelters across the United Kingdom, comprising 818 faecal sampl
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10

Mohr, Christina [Verfasser]. "Influence of hepatitis B virus surface protein variants associated with antiviral resistance on viral assembly and secretion of hepatitis B and hepatitis D viruses / Christina Mohr." Gießen : Universitätsbibliothek, 2014. http://d-nb.info/1068540001/34.

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11

Gamon, Thaís Helena Martins. "Estudo da etiopatogenia do vírus da raiva utilizando um modelo murino de neuroinfecção." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-16092015-123105/.

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A raiva é uma zoonose quase sempre fatal, que causa milhares de mortes humanas por ano em todo mundo. Essa enfermidade manifesta-se nos mamíferos em duas formas clínicas: furiosa e paralítica. Distinções em relação à evolução, manifestações clínicas, lesões, distribuição e respectiva carga viral no Sistema Nervoso Central (SNC) podem estar relacionadas às características de neuroinvasividade e neuropatogenicidade das diferentes variantes do vírus da raiva (RABV). O objetivo deste projeto foi estabelecer um modelo para o estudo da patogênese da raiva em camundongos inoculados com vírus fixo CVS
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12

Menezes, Wanessa Basílio de. "Caracterização Molecular de isolados do vírus rábico dos Estados do RN,PB e PB." Universidade Federal Rural do Semi-Árido, 2013. http://bdtd.ufersa.edu.br:80/tede/handle/tede/336.

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Made available in DSpace on 2016-08-15T20:31:10Z (GMT). No. of bitstreams: 1 WanessaBM_DISSERT.pdf: 2965999 bytes, checksum: 15229eda004f6eb0eefb1d93516bce41 (MD5) Previous issue date: 2013-08-29<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Rabies is a viral disease that affects the central nervous system, causing encephalitis and almost 100% lethality once the signs and symptoms start. This study describes the genetic characterization of rabies virus strains isolated in samples from domestic and wild animals acquired in the states of Rio Grande do Norte, Paraíba and Per
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13

Millet, Antoine. "Caractérisation quantitative et génétique de la dynamique sanguine et tissulaire du virus de l'immunodéficience simienne chez le macaque cynomolgus en histoire naturelle The extensive widespread of SIV distribution in macaques suggests that secondary lymphoid tissues are the main drivers of viral dynamics Optimal maturation of the SIV‐specific CD8+ T cell response after primary infection is associated with natural SIV control. ANRS SIC study Modeling acute SIV infection suggests that early establishment of cytotoxic response drives the virological control, and unravels heterogeneous infected cells populations." Thesis, Sorbonne Paris Cité, 2018. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=2119&f=17058.

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L'infection par le Virus de l'Immunodéficience Simienne (SIV) persiste dans l'organisme en raison des cellules infectées contenant le génome viral intégré. Ces cellules dites « Réservoirs » constituent l'obstacle majeur à l'éradication virale et sont au cœur de nouveaux challenges thérapeutiques. Le modèle simien permet d'explorer les tissus réservoirs et l'évolution virale dans l'organisme. Dans une première partie, l'objectif de notre travail a été de caractériser la dynamique du SIV dans le sang et les tissus, en l'absence de traitement. Dans le cadre du programme P-Visconti, 6 macaques ont
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14

Tabernero, Caellas David. "Estudi de la composició de la quasiespècies del virus de la hepatitis B a les regions codificants de les proteïnes de l’envolta i la polimerasa viral per seqüenciació massiva: associació de les seves variants genètiques amb el tractament antiviral de la hepatitis B crònica amb anàlegs de nucleòsids/nucleòtids." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/327310.

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Aquesta tesi doctoral es basa en dos estudis en els que s’analitzen les variants genètiques de la quasiespècies del virus de la hepatitis B (VHB) en una regió de la pauta oberta de lectura (ORF) de la polimerasa viral (P) on poden acumular-se mutacions relacionades amb la resistència a certs tractaments de la família dels anàlegs de nucleòsids/nucleòtids (NUCs). Aquesta anàlisi s’ha realitzat per seqüenciació massiva basada en tècniques d’“Ultra-deep pyrosequencing” (UDPS). Les mutacions seleccionades a causa del tractament antiviral a l’ORF P també poden produir canvis d’aminoàcid (aa) a l’OR
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15

Smith, Sarah D. "Selection of Generalists and Specialists in Viral Quasispecies." University of Toledo Health Science Campus / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=mco1224018547.

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16

Caetano, Diogo Gama. "Caracterização de variantes virais de HIV-1 em indivíduos soropositivos com perfil de controle da progressão para a AIDS e da replicação viralavaliação da ocorrência de variantes de escape da resposta imune." reponame:Repositório Institucional da FIOCRUZ, 2016. http://www.arca.fiocruz.br/handle/icict/15377.

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Giberson, Andrea N. "Adenovirus Chromatin: The Dynamic Nucleoprotein Complex Throughout Infection." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/24931.

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Adenovirus (Ad) is a widely studied DNA virus, but the nucleoprotein structure of the viral genome in the cell is poorly characterized. Our objective is to study Ad DNA-protein associations and how these affect the viral life cycle. Most of the viral DNA condensing protein, protein VII, is lost within a few hours of infection and this loss is independent of transcription. Cellular histones associate with the viral DNA after removal of protein VII, with a preferential deposition of H3.3. Micrococcal nuclease accessibility assays at 6 hpi showed laddering of the viral DNA, suggesting the genome
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18

Fages, Marie-Philippe Bertagnoli Stéphane. "Identification d'un nouveau variant apathogène du virus de la maladie hémorragique virale du lapin (RHDV)." [S.l.] : [s.n.], 2007. http://oatao.univ-toulouse.fr/1755/1/debouch_1755.pdf.

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19

Paez, David. "Étude de la variance génétique associée aux traits influençant le cycle vital du saumon atlantique." Thesis, Université Laval, 2011. http://www.theses.ulaval.ca/2011/28159/28159.pdf.

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20

Braham, Sharleen. "Development of strategies for the detection and characterisation of novel or variant enteric viruses : investigation of viral causes of outbreaks of gastroenteritis." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499172.

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21

Campos, Angélica Cristine de Almeida. "Estudo genético da variante do vírus da raiva mantida por populações do morcego hematófago Desmodus rotundus." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-14092011-175622/.

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Dados da Organização Mundial da Saúde (OMS) mostram que a raiva é um problema de saúde pública podendo acarretar sérios prejuízos ambientais e econômicos, a despeito da existência de vacinas eficazes de uso humano e veterinário. Segundo seu último informe, estima-se que no mundo em torno de 55.000 pessoas por ano morrem de raiva. O cão permanece como principal transmissor da raiva para o homem e também como principal vítima da doença. Nos países que conseguiram controlar a raiva em animais domésticos, o vírus se mantém circulante na natureza por meio dos animais silvestres, sendo os morcegos a
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22

Valls, Jimena Paola Hochmann. "Análise do impacto das proteínas E6/E7 de diferentes variantes moleculares de HPV-16 sobre as vias de transdução de sinal mediadas por MAPK." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-21092016-084921/.

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A infecção persistente por HPV-16 está fortemente associada ao risco de desenvolvimento de neoplasias do colo do útero, vagina, vulva, pênis, canal anal e orofaringe. O estudo detalhado da variabilidade nucleotídica intra-típica de HPV-16 resultou em importantes achados no que concerne à filogenia e evolução viral, e à história natural das infecções. Variantes Asiático-Americanas (AA) e E-350G de HPV-16 foram associadas com maior risco de persistência da infecção viral e desenvolvimento de câncer de colo de útero quando comparadas à variante Européia protótipo (E-P ou E-350T), embora esta aind
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23

Bloquel, Carole. "Thérapie génique non virale de variants du gène du récepteur soluble de type I du TNF-alpha humain. Application à différents modèles de pathologies inflammatoires." Phd thesis, Paris 7, 2005. http://pastel.archives-ouvertes.fr/pastel-00001807.

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Le TNF-α est une cytokine pro-inflammatoire jouant un rôle délétère dans de nombreuses pathologies. Nous nous sommes intéressés à l'inhibition du TNF-α à l'aide de variants du récepteur soluble de type I du TNF-α (hTNFR-Is) administrés par thérapie génique non virale. Trois variants ont été étudiés: un monomère hTNFR-Is, correspondant au récepteur soluble physiologique, une protéine chimérique hTNFR-Is/mIgG1, dont l'efficacité par administration protéique est reconnue, et une forme dimérique obtenue par association de deux fragments hTNFR-Is à l'aide d'un espaceur polyglycine. La vectorisation
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24

Akil, Abdellah. "Susceptibilité génétique des variants EP300 et PCAF au carcinome hépatocellulaire et rôle de septine 9, PIAS1 et SUMO1 dans la réplication du virus de l'hépatite C." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA11T079/document.

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Le carcinome hépatocellulaire (CHC) est la tumeur maligne primitive du foie la plus fréquente (90 % des cas). Le CHC est le cinquième cancer par ordre de fréquence à l'échelon mondial, la troisième cause de décès par cancer dans le monde entier et son incidence est actuellement croissante. Parmi Les principaux facteurs prédictifs de survenue de CHC ; les altérations génétiques, l'alcool et les infections par les virus des hépatites B (VHB) et C (VHC). Les travaux de thèse en cotutelle menés entre l’Universités Paris Sud 11-France et l’Université Mohammed V- Rabat –MAROC ont porté essentielleme
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25

Mayhuire, Ponce Hofman. "Proyecto constructivo variante de población de la carretera nacional N-122 a su paso por Tarazona (Zaragoza – España)." Bachelor's thesis, Pontificia Universidad Católica del Perú, 2020. http://hdl.handle.net/20.500.12404/19076.

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La presente tesis tuvo como objetivo el diseño geométrico de una nueva carretera de índole nacional para aliviar el concurrido tráfico rodado pesado que circula en la actual travesía (carretera N-122) en la localidad de Tarazona en una extensión de poco más de 9 kilómetros; para efectuar dicho propósito se realizó un estudio exhaustivo de los diferentes condicionantes y servicios existentes en el emplazamiento del proyecto, a su vez se hicieron los estudios topográficos, geológicos/geotécnicos e hidrológicos, así como también los cálculos hidráulicos para diseñar las obras de drenaje nec
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26

Guevara, Delgado Percy Jose Manuel, and Ita Jherson Daniel Norabuena. "Análisis y propuesta de mejora de la seguridad vial en la carretera Panamericana Norte, tramo variante de Pasamayo del km 55 al km 70 aplicando la metodología del manual de seguridad vial." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2019. http://hdl.handle.net/10757/626485.

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Entre los años 2015 y 2017 se aprecia el incremento de accidentes de tránsito en la red vial no urbana (carreteras), debido probablemente debido al aumento del flujo vehicular, el deficiente diseño geométrico, el deterioro y falta de mantenimiento de la vía. El tramo Variante de Pasamayo de la carretera PE-1N correspondiente a la Red Vial N° 5, no está excluida de este cambio, observándose como los accidentes de tránsito se han incrementado en esta vía. Debido a esta problemática es necesario determinar que herramientas de seguridad vial son necesarias implementar en la carretera Variante de P
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27

Nguyen, Hai Le. "HIV-1 minority variants associated with drug resistance to reverse transcriptase and integrase inhibitors and genetic barrier for the development of resistance to integrase inhibitors." Paris 7, 2012. http://www.theses.fr/2012PA077051.

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Les variants minoritaires résistants (VMR) du VIH-1 aux antirétroviraux n'ont pas été étudiés en Thaïlande. Deux groupes de patients dont le génotypage conventionnel n'a pas montré de mutations associées à la résistance ont été inclus dans l'étude: 104 patients récemment infectés, naïfs de traitement antirétro viral et 22 patients en échec de traitement de première ligne par les inhibiteurs non-nucléosidiques de la transcriptase inverse. Les résultats de pyroséquençage ont montré que la prévalence des variants minoritaires Y181C et M184V dans les 2 groupes est faible en Thaïlande. Le rôle des
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28

Beskow, Anna. "Genetic Risk Factors for Cervical Carcinoma in situ." Doctoral thesis, Uppsala universitet, Institutionen för genetik och patologi, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3318.

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Oncogenic human papillomaviruses (HPVs) are implicated in 99.7 % of cervical cancer cases but require the co-operation of other factors. To investigate potential genetic risk factors we have typed the HLA class II DRB1 and DQB1 loci in 478 women diagnosed with cervical carcinoma in situ and in 608 age-matched controls. Quantitative measurements of HPV 16, HPV 18/45 and HPV 31 were obtained. The DRB1*1501 and DQB1*0602 alleles were found to increase the risk of HPV 16 infection. Carriers of DRB1*1501 and DQB1*0602 were also shown to have an increased risk of a higher viral load compared to non
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Beby-Defaux, Agnès. "Pathogénèse du syndrome sec associé à l'infection par le virus HTLV-1 : variants et syndrome sec ; infection productrice d'une lignée épithéliale d'origine salivaire ; étude de la régulation du promoteur de l'interleukine 6 par la protéine virale Tax." Poitiers, 2003. http://www.theses.fr/2003POIT1402.

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30

Wurtzer, Sébastien. "Importance de l'environnement cellulaire pour la réplication du virus de l'immunodéficience humaine." Paris 7, 2006. http://www.theses.fr/2006PA077197.

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Nous avons souhaité évaluer l'importance du contexte cellulaire pour la réplication rétro virale du virus de l'immunodéficience humaine de type 1 (VIH-1). Deux paramètres ont été abordés : i) l'impact de modifications métaboliques des cellules cibles sur la résistance du VIH-1 aux analogues de nucléosides ; ii) l'influence d'une structure particulière du VIH, le PPT central, sur la restriction rétrovirale par des protéines cellulaires de la famille APOBEC. L'ensemble de nos travaux souligne l'impact de deux paramètres importants pour la réplication du VIH-1. Ils démontrent en quoi l'environnem
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Martel, Nora. "Variabilité génétique du virus de l'hépatite B et implication sur le diagnostic et la pathogénèse." Phd thesis, Université Claude Bernard - Lyon I, 2012. http://tel.archives-ouvertes.fr/tel-00865253.

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L'infection chronique ou occulte par le virus de l'hépatite B (HBV) est l'un des facteurs de risque les plusimportants pour le développement de carcinome hépatocellulaire viro-induit. Malgré la petite taille dugénome et les contraintes imposées par l'organisation de ce génome, le HBV présente une grandevariabilité génétique qui est le résultat des erreurs générées lors de l'étape de reverse transcription maisaussi, lors des processus de sélection et d'adaptation. Durant l'infection, une relation étroite hôte-viruss'établit. La population virale est caractérisée par la présence de quasi-espèces
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Thieulent, Côme. "Criblage in vitro de molécules antivirales contre l'herpèsvirus équin-1 par impédancemétrie et évaluation clinique de l'effet du valganciclovir Screening and evaluation of antiviral compounds against Equid alpha-herpesviruses using an impedance-based cellular assay Identification of antiviral compounds against equid herpesvirus-1 using real-time cell assay screening: Efficacy of decitabine and valganciclovir alone or in combination Screening of potential antiviral molecules against equid herpesvirus-1 using cellular impedance measurement: dataset of 2,891 compounds New EHV-1 variant identified | Veterinary Recordvir réduit les signes cliniques, l'excrétion virale et la virémie chez des poneys infectés expérimentalement par la nouvelle souche C2254 d'herpèsvirus équin 1 Oral administration of valganciclovir reduces clinical signs, virus sheedind and cell-associated viremia in ponies experimentally infected with the new variant C2254 of equid herpesvirus-1." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC421.

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Neuf herpèsvirus sont connus pour infecter les équidés. Parmi eux, l’herpèsvirus équin 1 (HVE-1) induit les formes de la maladie les plus graves. En effet, ce virus provoque des troubles respiratoires, des avortements, des morts néonatales et des troubles nerveux qui mènent souvent à l’euthanasie de l’animal. La prophylaxie, reposant sur les bonnes pratiques sanitaires et la vaccination, demeure le meilleur moyen de lutte contre l’ensemble des herpèsvirus équins. Des vaccins qui réduisent efficacement les troubles respiratoires et la dissémination de l’HVE-1 ont été développés. Cependant, ces
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33

Tavares, Lucas Alves. "O envolvimento da proteína adaptadora 1 (AP-1) no mecanismo de regulação negativa do receptor CD4 por Nef de HIV-1." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17136/tde-06012017-113215/.

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O Vírus da Imunodeficiência Humana (HIV) é o agente etiológico da Síndrome da Imunodeficiência Adquirida (AIDS). A AIDS é uma doença de distribuição mundial, e estima-se que existam atualmente pelo menos 36,9 milhões de pessoas infectadas com o vírus. Durante o seu ciclo replicativo, o HIV promove diversas alterações na fisiologia da célula hospedeira a fim de promover sua sobrevivência e potencializar a replicação. A rápida progressão da infecção pelo HIV-1 em humanos e em modelos animais está intimamente ligada à função da proteína acessória Nef. Dentre as diversas ações de Nef está a regula
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Madzorera, Vimbai Sharon. "Engineering HIV viral variants as immunogens to stimulate Broadly Neutralizing Antibodies." Thesis, 2018. https://hdl.handle.net/10539/25326.

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A dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Master of Science in Medicine Johannesburg, 2018.<br>Southern Africa is currently the most affected region of the world in terms of the HIV/AIDS pandemic and despite decades of research into this virus, a vaccine that is adequately effective is yet to be developed. However, it is widely believed that broadly neutralizing antibodies (bNAbs) are likely to be required for protection. Eliciting bNAbs by vaccination has been challeng
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Faragher, Susan G. "Sequence studies on natural and laboratory-derived virulence variants of Ross River virus." Phd thesis, 1987. http://hdl.handle.net/1885/142636.

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Lobigs, Mario. "Genotypic and phenotypic studies on natural isolates and laboratory-derived variants of flaviviruses." Phd thesis, 1987. http://hdl.handle.net/1885/142634.

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Meek, Andrew D. J. "Genetic and phenotypic studies on virulence variants of Ross River virus." Phd thesis, 1986. http://hdl.handle.net/1885/144142.

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Chu, Yu-Ju, and 朱昱如. "Association study of human leukocyte antigen 3’untranslated region variants and aflatoxin exposure with the progression of viral hepatitis." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/x49m2s.

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博士<br>國立陽明大學<br>微生物及免疫學研究所<br>105<br>I. Association study of genetic variants of human leukocyte antigen 3'UTRs with the outcomes of chronic hepatitis B virus infection Background and aims: The disease spectrum of chronic hepatitis B virus (HBV) infection is highly variable and the contributing factors remain largely unknown. HLA-DP variants showed the strongest genome-wide association with chronic hepatitis B. This study aims to identify the HLA 3’UTR variants associated with the seroclearance of HBV viral markers and cirrhosis and hepatocellular carcinoma (HCC). Genetic variants in the 3’
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"Sequence variation and risk association of human papillomavirus type 16 variants in East Asia." 2013. http://library.cuhk.edu.hk/record=b5549313.

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人類乳頭瘤病毒 (HPV) 是引起宮頸癌的必要條件。在高危型HPV中，以HPV16在癌症樣本中最為常見，其全球盛行率達50%以上。近年來，用以辨認HPV16變異子譜系的序列特徵已經建立。雖然這個系統建基於全球的HPV16變異株，但是它只包含了四個亞洲地區。為了改善這個系統於亞洲樣本的準確性，是次研究收集了更多亞洲地區的序列。<br>是次研究提供了在香港和韓國收集的HPV16樣本的系統發生史及序列變異 (LCR、E6 和 E7)。此外，是次研究也檢測了HPV16變異株的在兩地的分佈和致癌風險。<br>是次研究從香港和韓國收集了329個HPV16呈陽性的宮頸樣本。利用LCR、E6、E7 和整合的LCR-E6基因序列以極大似然法來構建HPV16變異株的系統發生樹。序列變異會按照系統發生樹之拓撲結構來分類並詳細描述。卡方檢驗或費雪精確性檢定用於分析HPV16變異株在兩地的分佈和致癌風險。<br>是次研究結果顯示用以辨認HPV16變異子譜系的序列特徵需加以改善。我們建議採用A7287C/T作為亞洲子譜系的序列特徵，以替代原有的A7287C。有關HPV16變異株的地理分佈，亞洲和歐洲的變異株在香港 (亞洲變異株: 70%，歐洲變異株: 25.3%) 和韓國 (亞洲變異株: 61.2%，歐洲變異株: 20.2%) 均十分普遍。另外，1和2型亞美變異株在香港和韓國的分佈有著明顯差別 (1型亞美變異
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40

Herman, Melissa. "CD8+ T cells in HIV: The impact of responses to consensus HIV epitopes and their natural variants and implications for differential disease progression." 2015. http://hdl.handle.net/1993/30714.

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For three decades, CD8+ T cells have been implicated in the control of HIV, ever since early studies revealed that a temporal correlation exists between the emergence of CD8+ T cells and the decline of viral loads in HIV infection. Subsequently, a large body of research focusing on the impact of CD8+ T cell responses on HIV has been produced. The central aim of this thesis was to investigate the relationship between CD8+ T cells and control of HIV, with a focus on the differences in CD8+ T cell responses to consensus HIV epitopes and their naturally occurring varia
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Chamberland, Annie. "Effet de l'initiation du traitement antirétroviral sur la diversité virale du VIH." Thèse, 2009. http://hdl.handle.net/1866/3470.

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L’épidémie du VIH-1 dure maintenant depuis plus de 25 ans. La grande diversité génétique de ce virus est un obstacle majeur en vue de l’éradication de cette pandémie. Au cours des années, le VIH-1 a évolué en plus de cinquante sous-types ou formes recombinantes. Cette diversité génétique est influencée par diverses pressions de sélection, incluant les pressions du système immunitaire de l’hôte et les agents antirétroviraux (ARV). En effet, bien que les ARV aient considérablement réduit les taux de morbidité et de mortalité, en plus d’améliorer la qualité et l’espérance de vie des personnes
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Chou, Po-Hao, and 周柏豪. "Establish an Analysis Framework for Detecting Sub-populations of Avian Influenza Virus Variants by Next Generation Sequencing for Better Preparedness and Early Warning of Viral Variants with Increasing Epidemic Potential through Virological Surveillance." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/02346652525438165946.

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碩士<br>國立臺灣大學<br>流行病學與預防醫學研究所<br>104<br>Prevention of avian influenza viruses (AIVs) has become an important issue in recent years. Several severe outbreaks of AIVs in poultry farms of Taiwan leading to tremendous economic loss and increasing human risk of acquiring infection with AIVs. In fact, virological surveillance system has relied on traditional method using Sanger sequencing, but it has still struggled to guide early warning for successful preventing outbreaks of AIVs. Recently, next-generation sequencing (NGS), a novel method of DNA sequencing, has been widely applied to virological su
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43

Mancuso, Nicholas. "Algorithms for Viral Population Analysis." 2014. http://scholarworks.gsu.edu/cs_diss/85.

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The genetic structure of an intra-host viral population has an effect on many clinically important phenotypic traits such as escape from vaccine induced immunity, virulence, and response to antiviral therapies. Next-generation sequencing provides read-coverage sufficient for genomic reconstruction of a heterogeneous, yet highly similar, viral population; and more specifically, for the detection of rare variants. Admittedly, while depth is less of an issue for modern sequencers, the short length of generated reads complicates viral population assembly. This task is worsened by the presence of b
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Artyomenko, Alexander. "Methods for Viral Population Analysis." 2017. http://scholarworks.gsu.edu/cs_diss/128.

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The ability of Next-Generation Sequencing (NGS) to produce massive quantities of genomic data inexpensively has allowed to study the structure of viral populations from an infected host at an unprecedented resolution. As a result of a high rate of mutation and recombination events, an RNA virus exists as a heterogeneous "swarm". Virologists and computational epidemiologists are widely using NGS data to study viral populations. However, discerning rare variants is muddled by the presence of errors introduced by the sequencing technology. We develop and implement time- and cost-efficient strateg
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45

Huey-Huey, Chua. "Stabilization of TSG101 protein by its splice variant and the impact on Epstein-Barr viral late gene transcription." 2007. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2501200715433100.

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Chua, Huey-Huey, and 蔡慧慧. "Stabilization of TSG101 protein by its splice variant and the impact on Epstein-Barr viral late gene transcription." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/45645156120207518861.

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博士<br>國立臺灣大學<br>微生物學研究所<br>95<br>The fidelity of splicing is lost in most cancers resulting in aberrant splicing of pre-mRNA. Tumor susceptibility gene 101 (TSG101) is a frequent target of these splicing defects, as evidenced by co-expression of its full-length transcript with truncated mRNA isoforms in a variety of human cancers. This study demonstrates that nasopharyngeal carcinomas (NPC) tissues express an abundance of TSG101 transcripts with nucleotides 154-1054 deleted (designated TSG101-247). In particular, Epstein-Barr virus (EBV)-infected NPC cells harbor this splice variant, and the i
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Kabue, Ngandu Jean Pierre. "Molecular characterization of norovirus stains circulating in rural communities of Limpopo Province of South Africa." Thesis, 2018. http://hdl.handle.net/11602/1163.

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PhD (Microbiology)<br>Department of Microbiology<br>Globally, one in ten child deaths before the age of 5 years is due to diarrheal disease, causing almost 800,000 mortalities worldwide, which mostly occur in Sub-Saharan Africa and South Asia. Eighty-eight percent (88%) of diarrheal deaths worldwide are attributable to unsafe water, inadequate sanitation and poor hygiene. Unsanitary environments and poor hygiene practices allow diarrhea causing pathogens including viruses, bacteria and parasites to spread more easily. Norovirus (NoV) are now considered the most common cause of outbreaks
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Armindo, Rui Miguel Duarte. "Variantes da proteína viral R (VPR) de HIV-1 e progressão da sindrome de imunodeficiência adquirida (SIDA) : impacto de polimorfismos associados a receptores para fungos." Master's thesis, 2015. http://hdl.handle.net/10316/40737.

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Trabalho final de mestrado integrado em Medicina, apresentada á Faculdade de Medicina da Universidade de Coimbra<br>Introdução. Dectina-1 é um recetor membranar das células do sistema imunitário inato responsável pelo reconhecimento de elementos da parede de fungos. Alterações no gene que codifica para esta proteína estão relacionadas com aumento da suscetibilidade a infeções oportunistas, em particular em indivíduos HIV-positivos, podendo correlacionar-se com a progressão da Síndrome da Imunodeficiência Adquirida. Materiais e Métodos. Otimizou-se e implementou-se um protocolo que, em amostra
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