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Dissertations / Theses on the topic 'Viral'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Ekberg, Johan, and Fredrik Isaksson. "Viral Marknadsföring." Thesis, Linköping University, Department of Management and Economics, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-705.

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<p>Bakgrund: I massmedia har det på senare tid börjat uppmärksammas ett nytt fenomen inom internetbaserad marknadsföring som kallas för viral marknadsföring. Det har dock inte gjorts några studier om vad begreppet egentligen innebär. </p><p>Syfte: Att ge en innebörd åt begreppet viral marknadsföring och att undersöka de faktorer som kan påverka möjligheten att kunna utnyttja viral marknadsföring. </p><p>Avgränsningar: I denna studie har vi avgränsat oss genom att säga att teorierna kring viral marknadsföring endast går att applicera på Internet. I studien behandlas endast konsumentrelaterade p
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2

Azevedo, Lúcia Alexandra Fernandes. "Bronquiolite viral aguda." Master's thesis, Universidade da Beira Interior, 2009. http://hdl.handle.net/10400.6/889.

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Contextualização: A bronquiolite é a infecção das vias respiratórias inferiores mais comum em crianças com idade inferior a dois anos, sendo uma importante causa de internamento nos meses de Inverno. Resulta da infecção e inflamação da mucosa respiratória das vias aéreas distais por uma grande variedade de vírus sazonais, sendo o Vírus Sincicial Respiratório o agente etiológico mais frequentemente implicado. O diagnóstico é baseado na história clínica típica e no exame físico. O tratamento é essencialmente de suporte, contudo persiste o recurso a terapêuticas cuja prática não é suficientemente
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3

Kymalainen, Hanna. "Development of viral & non-viral episomal vectors for gene therapy applications." Thesis, University of London, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589000.

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Gene therapy consists of methods which attempt to repair or replace defective genes responsible for disease, or to add genes to a therapeutic effect. To achieve this, two episomally maintained recombinant viral vectors have shown promising results: integration-deficient lentiviral vectors (IDLVs), and adeno-associated virus (AA V) vectors. The non-integrating nature of these vectors improves their safety profile but also limits transgene retention as nuclear episomes generally get lost during cell division. In the present study, the establishment of stable replicating episomes via transduction
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4

Paton, David James. "Bovine viral diarrhoea virus : studies of viral epitopes and of porcine infections." Thesis, University of Surrey, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317374.

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5

Ruoss, Sven. "Erfolgsfaktoren des Viral Marketing." St. Gallen, 2008. http://www.biblio.unisg.ch/org/biblio/edoc.nsf/wwwDisplayIdentifier/02600278002/$FILE/02600278002.pdf.

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6

Stirnemann, Sandra. "Verhaltenswirksamkeit des Viral Marketing." St. Gallen, 2008. http://www.biblio.unisg.ch/org/biblio/edoc.nsf/wwwDisplayIdentifier/02601128002/$FILE/02601128002.pdf.

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7

Gangadharan, Bevin. "Proteomics in viral disease." Thesis, University of Oxford, 2006. http://ora.ox.ac.uk/objects/uuid:c66c53ed-a824-4f99-8f2b-d2bc65a984c7.

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The separation, identification, and characterisation of the proteins present in a tissue or biological sample is called ‘proteomics’. This technique can be used for example to identify biomarkers and investigate signalling pathways. Increasingly, proteomics is being applied to the analysis of virus related samples; here two such examples are described. Presently there is no reliable non-invasive way of assessing liver fibrosis. Here a novel 2D-PAGE based proteomics study was used to identify potential fibrosis biomarkers. Serum from patients with varying degrees of hepatic scarring induced by
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8

Phillips, Angela Marie Ph D. Massachusetts Institute of Technology. "Chaperoning viral protein evolution." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/118276.

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Thesis: Ph. D. in Biological Chemistry, Massachusetts Institute of Technology, Department of Chemistry, 2018.<br>Cataloged from PDF version of thesis. Vita.<br>Includes bibliographical references.<br>Preventing viral pandemics and developing effective antiviral therapeutics demands understanding the molecular mechanisms that both potentiate and constrain viral evolution. The rapid evolution of viruses is mediated in part by their high mutation rates, enabling resistance to antiviral drugs, seasonal vaccines, and innate and adaptive immune responses. Fortunately for us, the same mutations respo
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9

Larsson, Tom. "Kan jag bli viral?" Thesis, Malmö högskola, Fakulteten för teknik och samhälle (TS), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-20056.

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Integrationen av sociala medier i dagens samhälle har bidragit till framväxten av en mersammankopplad och global värld. En värld som erbjuder fler tekniska möjligheter än tidigare, men som även bidrar med nya utmaningar. En av dessa utmaningar är hur man ska agera för att bli positivt utmärkt på den alltmer konkurrensutsatta arbetsmarknaden. Denna studie syftar till att angripa denna utmaning genom att undersöka hur den sociala applikationen Instagram kan användas som en kanal för personlig marknadsföring. Studiens slutsatser, vilka är baserade på en kombination av resultat från litteraturstud
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10

Nishikawa, Hiroki. "Development of Novel Anti-viral Agents against Class I Viral Membrane Fusion Process." 京都大学 (Kyoto University), 2011. http://hdl.handle.net/2433/142504.

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11

Klinger, Michaela. "Virales Marketing : die Macht der sozialen Netzwerke /." Saarbrücken : VDM, Müller, 2006. http://deposit.d-nb.de/cgi-bin/dokserv?id=2874943&prov=M&dok_var=1&dok_ext=htm.

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12

ALBUQUERQUE, Breno Moacir Farias de. "Aplicação da PCR em Tempo Real Para Detecção, Tipificaçãoe Carga Viral de Papilomavírus Bovino." Universidade Federal de Pernambuco, 2012. https://repositorio.ufpe.br/handle/123456789/18509.

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Submitted by Caroline Falcao (caroline.rfalcao@ufpe.br) on 2017-04-06T18:47:19Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) 2012-Dissertacao-BrenoAlbuquerque.pdf: 1989114 bytes, checksum: 513b1650c4c44605e3bda0afef185321 (MD5)<br>Made available in DSpace on 2017-04-06T18:47:19Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) 2012-Dissertacao-BrenoAlbuquerque.pdf: 1989114 bytes, checksum: 513b1650c4c44605e3bda0afef185321 (MD5) Previous issue date: 2012<br>O Papilomavírus bovino(BPV) é o ag
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13

Gholamzadeh, Caroline, and Karolina Jakobsson. "Viral Marketing : A Quantitative Study about how Viral Marketing affects the Consumers Buying Act." Thesis, Högskolan i Halmstad, Sektionen för ekonomi och teknik (SET), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-16192.

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14

Ilar, Sandra. "The Hunger Games Viral Marketing Campaign : A Study of Viral Marketing and Fan Labor." Thesis, Stockholms universitet, Institutionen för mediestudier, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-105864.

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This essay examines Lionsgate’s viral marketing campaign for The Hunger Games (Gary Ross, 2012) and the marketing teams’ use of new marketing techniques and the online fan base. The essay also asks the question to what extent the fans’ participation in Lionsgate’s marketing campaign can be called fan labor. The study is based on a film industrial perspective and academic literature that deals with film marketing, the film industry, fandom and digital labor. The material used for the analysis of The Hunger Games marketing campaign is collected from newspaper articles and news interviews with Li
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15

Stone, Jeffrey K. "Understanding viral quasispecies, viral escape, and implications for the design of novel antiviral strategies." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3261270.

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16

Moustafa, Rehab. "Characterization of functional determinants in the C-terminal part of hepatitis C virus E1 glycoprotein ectodomain." Thesis, Lille 2, 2019. http://www.theses.fr/2019LIL2S002/document.

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Aujourd’hui, le Virus de l'Hépatite C (VHC) infecte plus 70 millions de personnes dans le monde. L’Organisation mondiale de la santé prévoit l’élimination du virus VHC d’ici 2030, grâce aux récentes découvertes dans le milieu du développement médical. Ces derniers ont conduit à la production des antiviraux pangenotypiques à action directe (ADD). Le VHC est un virus enveloppé de l’ARN, avec une polarité positive. Il est constitué de nucléocapside entouré d’une membrane lipidique. La nucléocapside contient l’acide ribonucléique (ARN) et la protéine core. La membrane lipidique quant à elle contie
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17

Bryce, Michael. "Viral marketing potential and pitfalls." Saarbrücken VDM, Müller, 2004. http://deposit.ddb.de/cgi-bin/dokserv?id=2761738&prov=M&dok_var=1&dok_ext=htm.

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18

Hägele, Holger. "Molekulare Mechanismen viral getriggerter Glomerulonephritis." Diss., lmu, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-155778.

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19

Dou, Dengfeng. "Mammalian and viral protease inhibitors." Diss., Wichita State University, 2010. http://hdl.handle.net/10057/3281.

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Chronic Obstructive Pulmonary Disease (COPD) is currently the fourth leading cause of death in the US. COPD is a multi-factorial disorder characterized by an oxidant/antioxidant imbalance, inflammation, a protease/antiprotease imbalance and apoptosis. This dissertation describes a general strategy for the design, synthesis and biochemical evaluation of dual function inhibitors which could potentially interrupt the above disorder, thereby enhancing the treatment of COPD. An example of this type inhibitor based on the 1,2,5-thiadiazolidin-3-one scaffold has been proven effective against both hum
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20

Beier, Kevin. "Viral Tracing of Neuronal Circuitry." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10241.

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To understand how the nervous system processes information, a map of the connections among neurons is essential. Viral transsynaptic transmission has gained popularity as a method for labeling neural circuits. In particular, the development of retrograde monosynaptic tracing vectors has enabled visualization of the pre-synaptic inputs onto defined sets of postsynaptic neurons. This system utilized the rabies virus (RABV), in which the glycoprotein gene in the virus was deleted, and re-supplied in trans. In order to build alternative, more flexible tracers, we made recombinant VSV genomes, firs
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21

Adams, Edward Stephen. "Soil bacterial and viral dynamics." Thesis, University of Nottingham, 2006. http://eprints.nottingham.ac.uk/10201/.

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Viruses have been shown to be responsible for considerable bacterial mortality and nutrient cycling in aquatic systems. As yet no detailed studies have been published on the role of viruses in natural soil bacterial communities despite common knowledge that viruses exist in the soil. This thesis sought to address some key questions on the ecology of soil bacterial viruses and their hosts. Disturbance through soil desiccation, nutrient inputs, rhizosphere effects and protozoan predation pressure were investigated. The first study of lysogeny in natural soil systems was also undertaken. The work
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22

Procter, Charlotte Anne. "The post-viral fatigue syndrome." Thesis, Durham University, 1990. http://etheses.dur.ac.uk/6221/.

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Post-viral fatigue syndrome (myalgic encephalomyelitis) is a physically debilitating disorder associated with chronic disabling fatigue. This thesis presents two studies which look at the impact of illness from a personal-psychological and from a family perspective. The first investigates the psychological features of the syndrome. The prevalence of psychiatric disorder in 20 patients with the PVFS was determined. Sixty percent satisfied criteria for a current psychiatric disorder. Diagnoses were of neurotic depression and other neuroses. Only 25 % of a comparatively disabled group of 20 arthr
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23

Wang, Ami M. "Lifecycle of viral YouTube videos." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/97377.

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Thesis: S.B., Massachusetts Institute of Technology, Department of Architecture, 2014.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (page 28).<br>YouTube was founded in 2005 as a video-sharing website. Today, it's a powerhouse social media platform where users can upload, view, comment, and share content. For many, it's the first site visited when looking for songs, music videos, TV shows, or just general entertainment. Along with the sharing potential provided by social media like Twitter, Facebook, Tumblr, and more, YouTube videos have the potential to spre
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24

Wikramaratna, Paul Silva. "The evolution of viral diversity." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:1d718b15-af79-4567-84ef-f97f61f75369.

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This thesis focuses on the population dynamics of three antigenically diverse RNA viruses: dengue, influenza and HIV-1. It comprises a set of studies highlighting the roles of structural constraints on critical antigenic determinants, interactions between immune responses to different antigenic types, host lifespan, and the degree of mixing between different host populations in determining the epidemiology and within-host dynamics of these pathogen systems. Dengue exists in humans as a collection of four antigenically related serotypes. Although infection by one serotype appears to convey life
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25

Oliveira, Vivian Leite. "Impact of viral mmunomodulatory proteins." Doctoral thesis, Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica, 2013. http://hdl.handle.net/10362/11946.

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Dissertation presented to obtain the Ph.D degree in Biology<br>Cerca de 50% do genoma dos vírus de DNA evoluiu direcionado para a manipulação de importantes funções celulares do hospedeiro. Estas estratégias são muito diversas e conferem ao vírus vantagens importantes sobre o sistema imunitário do hospedeiro. Esses genes são, por isso, potenciais fontes de informação para a geração de novos fármacos dirigidos à manipulação da resposta imunológica na saúde e na doença. Esta tese centra-se na análise da função de dois genes virais distintos, ambos com funções imunomoduladoras. O gene do Víru
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26

Ahlberg, Jakob. "Successful Methods of Viral Marketing." Thesis, Internationella Handelshögskolan, Högskolan i Jönköping, IHH, Marketing and Logistics, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-39843.

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27

Mahadevan, Geetha B. "Viral suppression of host defenses." Link to electronic thesis, 2004. http://www.wpi.edu/Pubs/ETD/Available/etd-0507104-110551.

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28

Carratalà, Ripollès Anna. "Contaminació viral del medi ambient: persistència i traçabilitat / Environmental viral pollution: persistence and source tracking." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/111289.

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Les poblacions humanes i animals excreten una gran diversitat de virus patògens en les seves femtes i orina, de manera que l’aigua residual que generen representa un dels principals vehicles de la disseminació de patògens a les aigües superficials, subterrànies o costaneres i conseqüentment, als aliments. La contaminació del medi ambient suposa un risc greu de salut pública. S’ha estimat que en el conjunt del planeta, aproximadament 3.000 milions de persones no disposen d’aigua potable i que el 95% de l’aigua residual domèstica és abocada al medi ambient sense tractar. Aquesta tesi doctora
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29

Schobel, Seth Adam Micah. "The viral genomics revolution| Big data approaches to basic viral research, surveillance, and vaccine development." Thesis, University of Maryland, College Park, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10011480.

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<p> Since the decoding of the first RNA virus in 1976, the field of viral genomics has exploded, first through the use of Sanger sequencing technologies and later with the use next-generation sequencing approaches. With the development of these sequencing technologies, viral genomics has entered an era of big data. New challenges for analyzing these data are now apparent. Here, we describe novel methods to extend the current capabilities of viral comparative genomics. Through the use of antigenic distancing techniques, we have examined the relationship between the antigenic phenotype and the g
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30

Pelliccia, M. "STRATEGIES FOR ENHANCING VIRAL GENE TRANSFER AND THE THERMOSTABILITY OF VIRAL VECTORS IN VACCINE APPLICATIONS." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/265518.

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At the most basic level viruses are biological nano-containers constituted by genetic material enclosed in a protein shell, capsid. A peculiar feature of viruses, both bacterial and some eukaryotic viruses, lies in the high packaging density of the genome in order to fit itself in the small capsid and hence the high internal osmotic pressure. Virus is a relatively stable particle equipped with fascinating mechanical properties of the capsid that are crucial for the virus lifecycle. Viruses have only one purpose: infect a host cell for reproducing themselves in order to generate new viral proge
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31

Nilsson, Ida, and Magnus Svensson. "The viral makes you aware : how is brand association affected by viral marketing through individual networks." Thesis, Kristianstad University College, School of Health and Society, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-5930.

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<p>Nowadays the internet has become more and more important in today’s technology addicted society. Consumers of today use the internet as a tool to communicate, do shopping and search for information. Hence, the internet has become a convenient way for organizations to reach out to consumers in an easy and cheap way, specially through the tool viral marketing. In this paper we research the phenomenon brand awareness and brand association affected by viral marketing. This is done through two research questions: <em>How does a commercial affect consumers to create a network Viral marketing camp
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32

Douglas, Kimberly L. "Non-viral gene therapy : design and characterisation of novel non-viral vectors for improved cellular transfection." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=102495.

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The promise of gene therapy, once hailed as the medical treatment of the future, has yet to be achieved. Problems related to the safety and efficacy of gene therapies have checked the enthusiasm once surrounding this field. The future of gene therapy relies on the development of safe and effective non-viral vectors for gene delivery.<br>This doctoral thesis describes the development and evaluation of a novel nanoparticle system that demonstrates characteristics suitable for gene delivery purposes. The work presented in this thesis is divided into three main phases: (1) Development of a novel d
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33

Jung, Cindy. "Quantitative analysis of lentivirus incorporation of heterologous viral and non-viral proteins for lung gene therapy." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/26648.

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Thesis (Ph.D)--Biomedical Engineering, Georgia Institute of Technology, 2008.<br>Committee Chair: Joseph M. Le Doux; Committee Member: Andrés J. Garcia; Committee Member: Cheng Zhu; Committee Member: Nael McCarty; Committee Member: Richard Compans. Part of the SMARTech Electronic Thesis and Dissertation Collection.
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34

CORTESE, MARIA FRANCESCA. "HIV and HBV infection as models of viral DNA integration and mechanisms of viral-associated carcinogenesis." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2015. http://hdl.handle.net/2108/203036.

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My PhD was focused on two viruses, both responsible of persistent infection: HIV and HBV. The two viruses show high worldwide prevalence and both are associated with high morbidity and mortality. HIV establishes a persistent infection through different mechanisms, first of all with the integration of its DNA into the host genome, thus forming the provirus. However, a consistent part of the viral DNA within the infected cells is unintegrated (circular or not). The project following presented aims to analyse the kinetic of viral replication (measured as p24 production) and HIV DNA i
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35

ARMIJOS, RIVERA JORGE ISAAC. "Targeting cellular kinases and viral factors for molecular therapy of cancer, neurodegenerative diseases and viral infections." Doctoral thesis, Università degli studi di Pavia, 2018. http://hdl.handle.net/11571/1214796.

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36

Nobre, Rita Luisa Valentim de Avelar. "Viral interferon antagonists and antiviral drugs /." St Andrews, 2009. http://hdl.handle.net/10023/818.

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37

Gayarre, German, and Carlos Larrea. "Diffusion of innovative ideas : Viral marketing." Thesis, Halmstad University, School of Business and Engineering (SET), 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-1593.

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38

Flür, Katharina. "Molekulare Mechanismen der viral-getriggerten Glomerulonephritis." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-115463.

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39

Ibeh, Neke. "Inferring Viral Dynamics from Sequence Data." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35317.

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One of the primary objectives of infectious disease research is uncovering the direct link that exists between viral population dynamics and molecular evolution. For RNA viruses in particular, evolution occurs at such a rapid pace that epidemiological processes become ingrained into gene sequences. Conceptually, this link is easy to make: as RNA viruses spread throughout a population, they evolve with each new host infection. However, developing a quantitative understanding of this connection is difficult. Thus, the emerging discipline of phylodynamics is centered on reconciling epidemi
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40

Ljungberg, Karl. "Variable viral genes as genetic immunogens /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-399-6/.

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41

Estmer, Nilsson Camilla. "Viral Control of SR Protein Activity." Doctoral thesis, Uppsala : Acta Universatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5124-1/.

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42

Fleeton, Marina N. "Genetic vaccination against acute viral disease /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3811-3/.

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43

Bonhoeffer, Sebastian. "Models of viral evolution and pathogenesis." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294217.

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Gupta, Ajay. "Viral studies in renal transplant recipients." Thesis, University of Newcastle Upon Tyne, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519564.

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Eriksson, Mikael. "Viral Facebook integration i mobilspelet Gravel." Thesis, Linköpings universitet, Institutionen för datavetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-107533.

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Steinmetz, Nicole Franziska. "Viral capsids as programmable nanobuilding blocks." Thesis, University of East Anglia, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439897.

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47

Manley, Robyn Anna. "Emerging viral diseases of pollinating insects." Thesis, University of Exeter, 2017. http://hdl.handle.net/10871/29677.

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The risks posed by rapidly evolving RNA viruses to human and animal health are well recognized. Epidemics in managed and wildlife populations can lead to considerable economic and biodiversity losses. Yet, we lack understanding of the ecological and evolutionary factors that promote disease emergence. Host-switching viruses may be a particular threat to species important for human welfare, such as pollinating bees. Both honeybees and wild bumblebees have faced sharp declines in the last decades, with high winter mortality seen in honeybees. Infectious and emerging diseases are considered one o
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48

Matthews, Philip Trystan. "Viral interference with T lymphocyte recognition." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621627.

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49

Fischer, Gilberto Bueno. "Fatores prognosticos para bronquiolite viral aguda." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 1994. http://hdl.handle.net/10183/139229.

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Bronquiolite Viral Aguda (BVA) é uma doença de alta prevalência no Rio Grande do Sul e causa um importante número de hospitalizações em crianças menores de um ano de idade. Os pacientes com maior gravidade, nos três primeiros dias de internação, podem evoluir para insuficiência ventilatória e necessitarem oxigênio ou até ventilação mecânica, como forma de tratamento. Com o objetvo de identificar precocemente os episódios mais graves, investigaram-se fatores prognósticos através de sinais clínicos e laboratoriais, durante a hospitalização de crianças com BVA. Estudou-se uma coorte de 213 crianç
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50

Nikin-Beers, Ryan Patrick. "Immunoepidemiological Modeling of Dengue Viral Infection." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/82924.

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Dengue viral infection is a mosquito-borne disease with four distinct strains, where the interactions between these strains have implications on the severity of the disease outcomes. The two competing hypotheses for the increased severity during secondary infections are antibody dependent enhancement and original antigenic sin. Antibody dependent enhancement suggests that long-lived antibodies from primary infection remain during secondary infection but do not neutralize the virus. Original antigenic sin proposes that T cells specific to primary infection dominate cellular immune responses dur
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