Relevant bibliographies by topics / Virologist / Dissertations / Theses
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Dissertations / Theses on the topic 'Virologist'

Author: Grafiati
Published: 4 June 2021
Last updated: 28 July 2025

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1

Silva, Luís Filipe Tavares da. "Bioinformática e aplicações em virologia." Master's thesis, [s.n.], 2015. http://hdl.handle.net/10284/5173.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>Na década de 1940 foi inventado o primeiro computador. A informação construía-se ligando e desligando o sistema binário. Na década de 50, a descoberta da dupla hélice no ADNveio provar que a informação genética também é escrita ligando e desligando, não um sistema binário como o computador digital, mas quaternário. Mas, só foi nos anos 90 que a informática e a biologia juntaram-se, inicialmente para decifrar a estrutura do A
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2

Doornum, Gerard van. "Klinische virologie, omzien naar de toekomst." [S.l.] : Rotterdam : [de auteur] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/13240.

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Inaugurele rede Erasmus Universiteit Rotterdam. Inaugurale rede Erasmus MC, Universitair Medisch Centrum Rotterdam.<br>Rede In verkorte vorm uitgesproken ter gelegenheid van het aanvaarden van het ambt van bijzonder hoogleraar met als leeropdracht Kliische Virologie aan het Erasmus MC, faculteit van de Erasmus Universiteit Rotterdam op 22 februari 2008. Met lit. opg.
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3

Lemaître, Cécile. "Virologie moléculaire d'un rétrovirus endogène humain fonctionnel." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC329/document.

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Environ 8% du génome humain est constitué de rétrovirus endogènes (HERV). La famille de bétarétrovirus HERV-K(HML2), l'une des plus actives chez l'homme, est entrée il y a 45 millions d'années dans le génome des primates et s'est amplifiée efficacement depuis, et ce malgré l'existence de nombreuses protéines cellulaires, appelées facteurs de restriction, qui s'opposent à la réplication du virus dans la cellule hôte. La Tetherin/BST2, l'un d'entre eux, est une protéine membranaire capable de bloquer le relargage des virions dans le milieu extracellulaire et est active sur la plupart des virus e
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4

Granieri, Camilla <1981&gt. "Infezione occulta da Virus B: aspetti virologici e immunologici." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3498/1/Granieri_Camilla_tesi.pdf.

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5

Granieri, Camilla <1981&gt. "Infezione occulta da Virus B: aspetti virologici e immunologici." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3498/.

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6

Dreier, Sabrina. "Phylogenetische Analyse numerische Optimierungsmethoden und Anwendung in der Virologie /." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=983240914.

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7

Shannon-Lowe, Claire Deirdre. "Biochemical and virologic analysis of the HCMV encoded UL97." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406472.

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8

Tran, Nhu Mai. "Microencapsulation de cellules hépatiques pour des études de virologie." Compiègne, 2012. http://www.theses.fr/2012COMP2023.

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La culture de cellules hépatiques en trois dimensions (3D), ainsi que l’ingénierie tissulaire, trouvent à l’heure actuelle de nouvelles applications en bioingénierie, et notamment en virologie pour l’étude de l’hépatite C. En effet, la mise en place de nouvelles stratégies antivirales nécessite la maîtrise de la culture du virus de l’hépatite C (VHC) dans des conditions mimant la physiologie de l’infection naturelle. L’accès à de nouveaux modèles de culture cellulaire permissifs au VHC représenterait donc une innovation importante pour les études sur le VHC et la production massive du virus. L
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9

Coutard, Bruno. "Contribution de la biotechnologie à la virologie structurale et fonctionnelle." Aix-Marseille 2, 2007. http://theses.univ-amu.fr.lama.univ-amu.fr/2007AIX22046.pdf.

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10

Kaczmarek, Matthieu Marion Jean-Yves. "Des fondements de la virologie informatique vers une immunologie formelle." S. l. : S. n, 2008. http://www.scd.inpl-nancy.fr/theses/2008_KACZMAREK_M.pdf.

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11

Mattes, Frank Mathias. "Virologic and immunological studies of human cytomegalovirus in transplant patients." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445689/.

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Infection with human cytomegalovirus (HCMV), a member of the Betaherpesvirinae sub family is widespread. HCMV is a major pathogen in the fetus, transplant patients (solid and bone marrow) and patients infected with the human immunodeficiency virus (HIV). My first study analyzed the presence of HCMV, human Herpes Virus 6 (HHV 6) or human Herpes Virus 7 (HHV 7) by quantitative competitive polymerase chain reaction (QCPCR) in multiple organs collected from acquired immunodeficiency disease syn drome (AIDS) patients autopsy. The results showed that the presence of owl's eye in clusion bodies is hi
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12

Kaczmarek, Matthieu. "Des fondements de la virologie informatique vers une immunologie formelle." Thesis, Vandoeuvre-les-Nancy, INPL, 2008. http://www.theses.fr/2008INPL097N/document.

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Cette thèse aborde trois thèmes : la formalisation de la virologie informatique, l'élaboration de protections contre l'auto-reproduction et le problème de la détection des programmes malicieux. Nous proposons une formalisation s'appuyant sur les fondements de l'informatique théorique et sur les travaux fondateurs de la discipline. Nous obtenons un formalisme souple où le théorème de récursion prend le rôle d'un compilateur de virus informatiques. Ce théorème trouve alors la place qui lui manquait encore dans la théorie de la programmation. Ce formalisme nous fournit des bases suffisamment soli
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13

Kaczmarek, Matthieu. "Des fondements de la virologie informatique vers une immunologie formelle." Electronic Thesis or Diss., Vandoeuvre-les-Nancy, INPL, 2008. http://www.theses.fr/2008INPL097N.

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Cette thèse aborde trois thèmes : la formalisation de la virologie informatique, l'élaboration de protections contre l'auto-reproduction et le problème de la détection des programmes malicieux. Nous proposons une formalisation s'appuyant sur les fondements de l'informatique théorique et sur les travaux fondateurs de la discipline. Nous obtenons un formalisme souple où le théorème de récursion prend le rôle d'un compilateur de virus informatiques. Ce théorème trouve alors la place qui lui manquait encore dans la théorie de la programmation. Ce formalisme nous fournit des bases suffisamment soli
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14

Watanabe, Aripuanã Sakurada Aranha [UNESP]. "Pesquisa do vírus influenza HRSV e hMPV em uma população de idosos da cidade de Botucatu - São Paulo, Brasil." Universidade Estadual Paulista (UNESP), 2006. http://hdl.handle.net/11449/89984.

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Made available in DSpace on 2014-06-11T19:24:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2006Bitstream added on 2014-06-13T20:51:50Z : No. of bitstreams: 1 watanabe_asa_me_botfm.pdf: 435949 bytes, checksum: e2d8389a510d8ed3643dbe728b2b723a (MD5)<br>From about 200 virus that cause respiratory infections, only 8 are responsible for severe illness in children, immunodeficient adults and elderly, inc1uding Adenovirus, Influenza A and B, Parainfluenza 1, 2 and 3, Human RespÍratory Syncytial Vírus (HRSV) and Human Metapneumovirus (hMPV). Three of these virus are responsible for a signific
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15

Boher, Sylvie. "Analyse virologique des huitres et étude des cinétiques d'accumulation et de décontamination virale." Nancy 1, 1991. http://www.theses.fr/1991NAN10451.

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16

Watanabe, Aripuanã Sakurada Aranha. "Pesquisa do vírus influenza HRSV e hMPV em uma população de idosos da cidade de Botucatu - São Paulo, Brasil /." Botucatu : [s.n.], 2006. http://hdl.handle.net/11449/89984.

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Orientador: João Manuel Grisi Candeias<br>Resumo: Não disponível.<br>Abstract: From about 200 virus that cause respiratory infections, only 8 are responsible for severe illness in children, immunodeficient adults and elderly, inc1uding Adenovirus, Influenza A and B, Parainfluenza 1, 2 and 3, Human RespÍratory Syncytial Vírus (HRSV) and Human Metapneumovirus (hMPV). Three of these virus are responsible for a significant morbidity in elderly: Influenza, HRSV and hMPV. The nosocomial infection caused by these vÍruses can be fatal in hospitalized children and patients with other pathologies. With
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17

Wegmüller, Michael. "Allgemeine Virologie : ein interaktiver Kurs für Studierende der Veterinärmedizin und der Biologie /." Bern : [s.n.], 2003. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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18

Ocadaque, Crister JosÃ. "Clinical and epidemiological aspects of children pneumonia associated with four types of parainfluenza virus in Fortaleza-CE." Universidade Federal do CearÃ, 2016. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16327.

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FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico<br>As pneumonias sÃo problemas de saÃde publica mundial, especialmente em crianÃas menores que cinco anos de idade. Os vÃrus parainfluenza (VPI-1, 2 e 3) sÃo agentes frequentes de pneumonia, pouco se conhecendo sobre a participaÃÃo do VPI-4 devido a dificuldades do seu isolamento em cultura de cÃlulas, a ausÃncia de antÃgenos especÃficos para este vÃrus nos painÃis de rotina de detecÃÃo dos vÃrus respiratÃrios, alÃm de serem relacionados apenas a casos de infecÃÃes respiratÃrias leves. O objetivo do presente estudo à descre
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19

Zrein, Maan. "Applications de nouvelles methodes immuno-enzymatiques de diagnostic en virologie humaine et vegetale." Strasbourg 1, 1986. http://www.theses.fr/1986STR13088.

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20

Zrein, Maan. "Applications de nouvelles méthodes immuno-enzymatiques de diagnostic en virologie humaine et végétale." Grenoble 2 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb37601998n.

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21

CUCCHI, MICHEL, and CUCCHI MALGORZATA SZALA. "Modelisation d'une activite de biologie medicale : application a l'informatisation d'une serotheque en virologie." Lille 2, 1993. http://www.theses.fr/1993LIL2M075.

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22

Seto, Wai-kay Walter, and 司徒偉基. "Virologic and serologic kinetics in the natural history and treatment of chronic hepatitis B." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48671071.

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This thesis investigated how virologic and serologic kinetics of the hepatitis B virus (HBV) could influence the natural history and treatment of chronic hepatitis B (CHB). Virologic kinetics were described in the first five studies, with serologic kinetics being described in the next five. The first study delineated the HBV DNA profiles of 1,400 treatment-naive Asian CHB patients. Increasing viremia was noted with increasing age, highlighting the large therapeutic demand in Asian patients with hepatitis B e antigen (HBeAg)-negative CHB. The second study analyzed the association between vira
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23

Andreoletti, Laurent. "Etude du role des coxsackievirus b dans la physiopathologie des cardiomyopathies dilatees (doctorat : virologie)." Lille 2, 1997. http://www.theses.fr/1997LIL2T014.

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24

DORE, PETIT-MAIRE ISABELLE. "Utilisation des anticorps monoclonaux en virologie vegetale : diagnostic et etudes structurales de quelques tobamovirus." Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13097.

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Etude des epitopes reconnus par 18 anticorps monoclonaux diriges contre la proteine de l'enveloppe du virus de la mosaique du tabac, en mesurant leur reactivite vis-a-vis de differents mutants, virus et peptides synthetiques. Visualisation de la liaison entre anticorps monoclonaux et virus par microscopie electronique, dans differents tests elisa. Preparation d'anticorps monoclonaux permettant la detection du virus des taches annulaires de l'odontoglossum et du virus de la mosaique de la tomate
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Dore, Isabelle. "Utilisation des anticorps monoclonaux en virologie végétale diagnostic et études structurales de quelques tobamovirus /." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37604651w.

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26

Ruiz, Chavez Isaac. "Développement de nouvelles approches thérapeutiques en virologie et hépatologie : Small-Molecule Cyclophilin Inhibitors (SMCypI)." Thesis, Paris Est, 2019. http://www.theses.fr/2019PESC0041.

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Au sein du laboratoire, par une stratégie de conception de médicaments par la méthode des fragments, nous avons généré une nouvelle famille d'inhibiteurs de cyclophilines, les SMCypI (« Small-Molecule Cyclophilin Inhibitors »), non liée aux autres inhibiteurs de cyclophilines existants. Les cyclophilines sont des protéines cellulaires impliquées dans un grand nombre de processus biologiques. Toutefois, les inhibiteurs de cyclophilines disponibles possèdent de nombreux inconvénients qui rendent leur utilisation clinique difficile. Au cours de ma thèse nous nous sommes intéressés au développemen
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27

Dispinseri, S. "CARATTERIZZAZIONE VIROLOGICA E DETERMINAZIONE DELLA RISPOSTA NEUTRALIZZANTE IN PAZIENTI PEDIATRICI CON INFEZIONE DA HIV-1." Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/150263.

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The study of HIV-1 phenotypic, genotypic and antigenic variability is fundamental to understand pathogenic processes but also for the development of immunogens for vaccines. Mother-to-child transmission of HIV-1 and disease progression of infected children are still a major problem at world-wide level. The aim of the thesis was to study the phenotypic and genotypic variation of R5 viruses, in mother-child pairs as well as to characterize the neutralizing response in seropositive children with different disease progression. We have investigated in detail the phenotype of the clonal viral popula
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28

Helvoort, Antonius Adrianus Franciscus Joseph van. "Research styles in virus studies in the twentieth century controversies and the formation of consensus /." [Maastricht : Maastricht : Rijksuniversiteit Limburg] ; University Library, Maastricht University [Host], 1993. http://arno.unimaas.nl/show.cgi?fid=5863.

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Karina, Cunha Callado Ana. "Avaliação in vitro e in vivo da infecção por Lentivírus de pequenos ruminantes." Universidade Federal de Pernambuco, 2004. https://repositorio.ufpe.br/handle/123456789/1940.

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Made available in DSpace on 2014-06-12T15:53:19Z (GMT). No. of bitstreams: 2 arquivo5109_1.pdf: 4981987 bytes, checksum: 45983940c169b7f60379907b2e4ab868 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2004<br>Os lentivírus de pequenos ruminantes (SRLV) causam doença progressiva multissistêmica crônica, com longo período de incubação, que acomete caprinos e ovinos de todas as raças e idades. Estes vírus podem se manifestar de forma artrítica, respiratória, mamária e nervosa ou mesmo atingir vários órgãos, causando perda de peso e debil
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Kyosiimire-Lugemwa, Jacqueline. "Immunologic, virologic and genetic studies of HIV-1 infected long-term non-progressors in Uganda." Thesis, Imperial College London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.577315.

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HIV -l-specific T -cell responses are preserved in HIV -1 infected individuals with non- progressing HIV -1 disease. Evaluation of HIV -I-specific T -cell functionality; T -cell phenotype; HLA class; subtype, RNA and DNA levels of HIV -1; and other factors in long- term non-progressors (LTNP) in comparison with rapid progressors (RP) could reveal novel correlates of protection against disease progression. We show that HIV -1 RNA viral load, proviral DNA load and lipopolysaccharide (LPS) were positively correlated with each other and negatively correlated with CD4 count. We show that IFN-y Gag-
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Lobo, Raulene Rodrigues. "Padronização de técnicas de diagnóstico em virologia utilizando ovos embrionados de codorna como modelo biológico." Universidade Federal de Pelotas, 2015. http://repositorio.ufpel.edu.br:8080/handle/prefix/3425.

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Mhangwane, Shushu Rirhandzu Comfort. "Predicting early and late first-line antiretroviral therapy virologic failure, and switch to second-line therapy in a military population in South Africa." Diss., University of Pretoria, 2018. http://hdl.handle.net/2263/64177.

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The study involved retrospective data analysis using statistical methods to re-analyse data collected during a long-term study in a Human Immunodeficiency Virus infected population of South African National Defence Force employees and their dependents, where different parameters related to treatment and disease status of HIV infected patients were collected. This study attempted to identify possible predictors of both early and late occurrence of first-line antiretroviral therapy virologic failure, potential predictors of first-line antiretroviral virologic failure and for switching to second
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33

Johansson, Susanne. "Genomic Organization and Capsid Architecture of Ljungan Virus : a Novel Member of the Picornaviridae." Doctoral thesis, Högskolan i Kalmar, Naturvetenskapliga institutionen, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-46.

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Ljungan virus är ett virus som isolerades i Sverige i mitten på nittiotalet. Under perioden 1989-1992 avled flera svenska elitorienterare plötsligt i hjärtmuskelinflammation. Man misstänkte att orienterarna kunde ha utsatts för en vektorburen infektion eftersom de exponeras för djur som finns i skog och mark under träning och tävling. Det är sedan tidigare känt att sorkar är den naturliga reservoaren för ett annat virus (Puumala virus) som kan orsaka njurskada hos människor. Sorkantalet i vissa delar av Sverige varierar kraftigt från år till år i ett cykliskt förlopp. Man fann ett samband mell
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Kindberg, Elin. "Host genetic risk factors to viral diseases - a double-edged sword : Studies of norovirus and tick-borne encephalitis virus." Doctoral thesis, Linköpings universitet, Molekylär virologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-54923.

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It is today well known that the outcome of a certain infection depends on factors of both the host and the pathogen. Studies of host genetic susceptibility to infectious diseases aim to increase the understanding of why some individuals are more susceptible than others, to a certain infection. Knowledge of genetic susceptibility to a viral disease may be used in development of new therapeutic means, and also to recognize individuals who are at increased risk of severe symptoms if infected with a pathogen. It seems however that a risk factor for one disease may play a protective role in another
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Backström, Ellenor. "Regulation of Adenoviral Gene Expression by the L4-33K and L4-22K Proteins." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-101324.

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The splicing pattern during an adenovirus infection is shifted at the late phase towards using weaker splice sites, splicing out larger introns. Splicing of weak 3´ splice sites usually requires recognition of the 3´AG dinucleotide before the first catalytic step of splicing. Such splicing events are said to be AG-dependent and requires an interaction of both subunits of the cellular splicing factor U2AF with the 3´ splice site. We show that splicing of transcripts that are AG-dependent in uninfected nuclear extracts (NE) becomes AG-independent in nuclear extracts prepared form adenovirus late
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Vildevall, Malin. "The Norovirus Puzzle : Characterization of human and bovine norovirus susceptibility patterns." Doctoral thesis, Linköpings universitet, Molekylär virologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-68386.

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Winter vomiting disease is caused by norovirus (NoV) and affects millions of people every year resulting in 200.000 deaths among children in developing countries. It was observed early that not all individuals exposed to the norovirus became ill. The reason for this is now recognized to be dependent upon the secretor status of an individual. The secretor status determines the ability of an individual to express histo-blood group antigens (HBGA) on mucosa and in saliva. A non-secretor is unable to express HBGAs due to a mutation in a gene called FUT2. In this thesis, I have investigated the ant
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Somberg, Monika. "Cellular and Viral Factors that Control Human Papillomavirus Type 16 Late Gene Expression." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-150706.

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Human papillomavirus type 16 (HPV-16) is the major cause of cervical cancer. We speculate that inhibition of HPV-16 late gene expression is a prerequisite for establishment of persistence and progression to cervical cancer. This is based on the findings that the late proteins are found only in the nuclei of terminally differentiated epithelium, and are never detected in human papillomavirus infected cervical cancer cells. It is therefore of great importance to understand how HPV-16 controls the onset of the immunogenic proteins L1 and L2 in an infected cancer cell. HPV-16 late gene expression
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38

Buzón, Gómez Maria José. "Effect of the HIV-1 Integrase Inhibitor Raltegravir on Drug Susceptibility, Replication Capacity and Residual Viremia in HIV-infected Subjects." Doctoral thesis, Universitat Autònoma de Barcelona, 2010. http://hdl.handle.net/10803/3628.

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Raltegravir es el primer inhibidor de la integrasa del VIH-1 aprobado para su uso en pacientes infectados por el VIH. Sinembargo, como el resto de los inhibidores, la emergencia de mutaciones de resistencia limita su eficacia clínica. <br/>El entendimiento de la prevalencia diferencial del ratio de mutaciones dentro de la región codificadora de la integrasa en pacientes con tratamiento TARGA (Tratamiento Antirretroviral de Gran Actividad) pero sin inhibidores de la integrasa, podría ayudar a identificar si algunas mutaciones virales o polimorfismos naturales ocurren, y si la diversidad genétic
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Groussaud, Damien. "Modulation de la machinerie de O-GlcNACylation par l’oncoprotéineTax du virus HTLV-1 et implication dans la transactivation du promoteur viral." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB252/document.

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Le virus HTLV-1 est le seul rétrovirus humain oncogène découvert à ce jour à l’origine d’une lymphoprolifération maligne à cellules T, la leucémie aiguë de l’adulte (ATL). L’oncoprotéine Tax du virus HTLV-1 joue un rôle majeur dans l’établissement de la leucémie mais aussi dans la réplication du virus. Tax régule la transcription du promoteur viral situé au sein du LTR 5’ du virus, gouvernant ainsi sa propre production. Pour ce faire, Tax recrute des dimères du facteur de transcription cellulaire CREB, sous forme phosphorylée, au niveau d’éléments de réponse à l’AMP cyclique (vCRE) situés dans
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Guibal-Suavet, Jacqueline. "Des objectifs pédagogiques à la vidéo dans l'enseignement de l'immunologie et de la virologie en Pharmacie." Montpellier 1, 1991. http://www.theses.fr/1991MON13524.

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41

Funk, Anneke. "Identifizierung und funktionelle Modulation essentieller zellulärer Komponenten für die Propagation von Hepatitis-B-Viren." [S.l.] : [s.n.], 2004. http://elib.tu-darmstadt.de/diss/000508.

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D'Arce, Regina Celia Freitas. "Estudo das diferenças genomicas entre amostras de herpesvirus bovino tipo 1 e tipo 5 isoladas no Brasil atraves da analise com enzimas de restrição." [s.n.], 2000. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316641.

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Orientadores: Clarice Weis Arns, Paulo Michel Roehe<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-07-27T02:28:11Z (GMT). No. of bitstreams: 1 D'Arce_ReginaCeliaFreitas_M.pdf: 3168538 bytes, checksum: e41e78694d9c979d5127fba297b57e4b (MD5) Previous issue date: 2000<br>Mestrado
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43

Peoc'h, Katell. "La protéine << prion-like >> Doppel humaine : caractérisation et relation avec la protéine prion." Paris 5, 2003. http://www.theses.fr/2003PA05N096.

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Les prions sont des agents infectieux constitués de Prp sc isoforme modifiée de la protéine prion (PrP c), codée par PRNP. La protéine Doppel (Dpl) est codée par le gène PRND adjacent à PNRP. Quatre polymorphismes de PRND sont observés chez l'homme ; aucun n'influence la suceptibilité aux maladies à prions. L'expression de prnd reste inchangée après infection. La surexpression de Dpl ne module pas l'accumulation de PrPsc et l'expression cérébrale de Dpl n'est pas modifiée chez des patients atteints de maladie de Creutzfeld-Jakob. Dpl est retrouvée dans les cellules de Sertoli, le liquide sémin
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44

Coulibaly, Fasséli. "Etude structurale des birnavirus : identification des déterminants d'antigénicité, de virulence et d'assemblage : mise en évidence d'un lien évolutif entre virus à ARN(+) et à ARN double brin." Paris 11, 2003. http://www.theses.fr/2003PA112236.

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Les birnavirus occupent une place particulière parmi les virus icosaédriques non enveloppés. Ils sont à la fois proches des Reoviridae par leur organisation génomique et leur capside T=13 et proches de virus à ARN positif par leurs stratégies réplicatives et de morphogenèse. Ce travail présente la structure de particules subvirales à symétrie icosaédrique T=l de l'IBDV. Ces particules de 260 A de diamètre se composent de 60 sous-unités de la protéine d'attachement du virus, VP2. Celle-ci se replie sous la forme de deux domaines jelly rolls perpendiculaires reposant sur une base riche en hélice
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Déchaux, Jonathan. "Formalisation implémentation et tests d'une méthodologie et des techniques d'évaluation de logiciels antivirus : application aux virus de documents." Palaiseau, Ecole polytechnique, 2015. http://www.theses.fr/2015EPXX0094.

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Lauster, Susanne. "Untersuchung DI-DNA vermittelter Resistenz gegen Beet Curly Top Geminivirus (BCTV) in Zuckerrübe und Suche nach neuen Virusvarianten im Anbaugebiet Idaho, USA." [S.l.] : Universität Stuttgart , Fakultät Geo- und Biowissenschaften , Biologisches Institut, 2000. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB8619083.

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Rubio, Marcelo Luiz [UNESP]. "Estudo de potenciais inibidores de inibidores de infecção causada por Vírus Sincicial Respiratório em cultura de célula." Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/92502.

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Made available in DSpace on 2014-06-11T19:26:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-02-09Bitstream added on 2014-06-13T19:53:58Z : No. of bitstreams: 1 rubio_ml_me_sjrp.pdf: 553575 bytes, checksum: e63be6b1c41d36a603fd12ca20a88442 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação para o Desenvolvimento da UNESP (FUNDUNESP)<br>Paramyxoviridae, é um vírus envelopado com tamanho médio de 120 a 300nm, de simetria helicoidal, que apresenta um genoma de RNA fita simples não segmentado de polaridade negativa. Este genoma codifica 11 proteína
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Rubio, Marcelo Luiz. "Estudo de potenciais inibidores de inibidores de infecção causada por Vírus Sincicial Respiratório em cultura de célula /." São José do Rio Preto : [s.n.], 2009. http://hdl.handle.net/11449/92502.

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Resumo: Paramyxoviridae, é um vírus envelopado com tamanho médio de 120 a 300nm, de simetria helicoidal, que apresenta um genoma de RNA fita simples não segmentado de polaridade negativa. Este genoma codifica 11 proteínas, dentre as quais as glicoproteínas de membrana que são responsáveis pela infectividade do vírus. A proteína F, em associação com a proteína G e SH, é responsável pela fusão da membrana viral à célula que será infectada, ou seja, esta proteína proporciona a entrada e instalação do vírus na célula. Conhecer a forma de interação das proteínas da membrana viral com a célula que s
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Pacenti, Monia. "Studio dei correlati virologici, patologici e clinici in pazienti pediatrici trapiantati di rene: applicazione di nuove indagini molecolari." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3425935.

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The relevance of viral infections in allograft lesion development is still unclear, although some viruses such as HCMV, EBV, VZV, HHV6, HHV8, seem to have a particular role especially during the first months after transplantation, and the polyomavirus BK (BKV), JC (JCV) and the parvovirus B19, have been implicated in the occur of kidney injury after more time following transplant. In this study we investigated systemic and intrarenal viral infections in kidney transplant young recipients and we analysed the association of these data with the risk of acute rejection and chronic allograft inju
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Uglietti, A. "FATTORI PREDITTIVI DI RISPOSTA VIROLOGICA SOSTENUTA IN PAZIENTI CON COINFEZIONE HIV-HCV TRATTATI CON PEG-INTERFERONE E RIBAVIRINA." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/245615.

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Hepatitis C is a blood-borne infection caused by the hepatitis C virus (HCV). A chronic infection, which develops in most infected subjects, may lead to liver cirrhosis with ensuing liver dysfunction and liver cancer. About 30% of HIV-positive patients are coifected with HCV. The standard of care in HIV-HCV-coinfected subjects was a combination of pegylated interferon (peg-IFN)-alpha and ribavirin for 48 weeks until few months ago. The eradication of HCV was obtained in 20-55% of cases albeit with significant side effects. Further understanding of host factors that determine the effectivenes
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