Relevant bibliographies by topics / Virology / Dissertations / Theses
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Dissertations / Theses on the topic 'Virology'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Johansson, Susanne. "Genomic Organization and Capsid Architecture of Ljungan Virus : a Novel Member of the Picornaviridae." Doctoral thesis, Högskolan i Kalmar, Naturvetenskapliga institutionen, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-46.

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Ljungan virus är ett virus som isolerades i Sverige i mitten på nittiotalet. Under perioden 1989-1992 avled flera svenska elitorienterare plötsligt i hjärtmuskelinflammation. Man misstänkte att orienterarna kunde ha utsatts för en vektorburen infektion eftersom de exponeras för djur som finns i skog och mark under träning och tävling. Det är sedan tidigare känt att sorkar är den naturliga reservoaren för ett annat virus (Puumala virus) som kan orsaka njurskada hos människor. Sorkantalet i vissa delar av Sverige varierar kraftigt från år till år i ett cykliskt förlopp. Man fann ett samband mell
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2

Kindberg, Elin. "Host genetic risk factors to viral diseases - a double-edged sword : Studies of norovirus and tick-borne encephalitis virus." Doctoral thesis, Linköpings universitet, Molekylär virologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-54923.

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It is today well known that the outcome of a certain infection depends on factors of both the host and the pathogen. Studies of host genetic susceptibility to infectious diseases aim to increase the understanding of why some individuals are more susceptible than others, to a certain infection. Knowledge of genetic susceptibility to a viral disease may be used in development of new therapeutic means, and also to recognize individuals who are at increased risk of severe symptoms if infected with a pathogen. It seems however that a risk factor for one disease may play a protective role in another
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3

Backström, Ellenor. "Regulation of Adenoviral Gene Expression by the L4-33K and L4-22K Proteins." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-101324.

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The splicing pattern during an adenovirus infection is shifted at the late phase towards using weaker splice sites, splicing out larger introns. Splicing of weak 3´ splice sites usually requires recognition of the 3´AG dinucleotide before the first catalytic step of splicing. Such splicing events are said to be AG-dependent and requires an interaction of both subunits of the cellular splicing factor U2AF with the 3´ splice site. We show that splicing of transcripts that are AG-dependent in uninfected nuclear extracts (NE) becomes AG-independent in nuclear extracts prepared form adenovirus late
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4

Vildevall, Malin. "The Norovirus Puzzle : Characterization of human and bovine norovirus susceptibility patterns." Doctoral thesis, Linköpings universitet, Molekylär virologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-68386.

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Winter vomiting disease is caused by norovirus (NoV) and affects millions of people every year resulting in 200.000 deaths among children in developing countries. It was observed early that not all individuals exposed to the norovirus became ill. The reason for this is now recognized to be dependent upon the secretor status of an individual. The secretor status determines the ability of an individual to express histo-blood group antigens (HBGA) on mucosa and in saliva. A non-secretor is unable to express HBGAs due to a mutation in a gene called FUT2. In this thesis, I have investigated the ant
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5

Somberg, Monika. "Cellular and Viral Factors that Control Human Papillomavirus Type 16 Late Gene Expression." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-150706.

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Human papillomavirus type 16 (HPV-16) is the major cause of cervical cancer. We speculate that inhibition of HPV-16 late gene expression is a prerequisite for establishment of persistence and progression to cervical cancer. This is based on the findings that the late proteins are found only in the nuclei of terminally differentiated epithelium, and are never detected in human papillomavirus infected cervical cancer cells. It is therefore of great importance to understand how HPV-16 controls the onset of the immunogenic proteins L1 and L2 in an infected cancer cell. HPV-16 late gene expression
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6

Polstra, Abeltje Mette. "Human herpesvirus 8: virology and disease." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2004. http://dare.uva.nl/document/74171.

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7

Jensen, Stephanie Meryl, and Stephanie Meryl Jensen. "A Bioorthogonal Approach to Chemical Virology." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/621769.

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Dengue virus (DENV) is a mosquito-transmitted flavivirus that threatens approximately half of the world's population. In this dissertation, the use of bioorthogonal chemistry as a tool for researching emerging viral diseases, including DENV is explored. To this end, a bioorthogonally-modified amino acid was successfully installed within the proteome of DENV, which was used for the pull down of a known virus-protein interaction. This technology is intended to be broadly used for the determination of any virus-host interaction, through the installment of a non-perturbing modification that 1) doe
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8

Watanabe, Aripuanã Sakurada Aranha [UNESP]. "Pesquisa do vírus influenza HRSV e hMPV em uma população de idosos da cidade de Botucatu - São Paulo, Brasil." Universidade Estadual Paulista (UNESP), 2006. http://hdl.handle.net/11449/89984.

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Made available in DSpace on 2014-06-11T19:24:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2006Bitstream added on 2014-06-13T20:51:50Z : No. of bitstreams: 1 watanabe_asa_me_botfm.pdf: 435949 bytes, checksum: e2d8389a510d8ed3643dbe728b2b723a (MD5)<br>From about 200 virus that cause respiratory infections, only 8 are responsible for severe illness in children, immunodeficient adults and elderly, inc1uding Adenovirus, Influenza A and B, Parainfluenza 1, 2 and 3, Human RespÍratory Syncytial Vírus (HRSV) and Human Metapneumovirus (hMPV). Three of these virus are responsible for a signific
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9

Groussaud, Damien. "Modulation de la machinerie de O-GlcNACylation par l’oncoprotéineTax du virus HTLV-1 et implication dans la transactivation du promoteur viral." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB252/document.

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Le virus HTLV-1 est le seul rétrovirus humain oncogène découvert à ce jour à l’origine d’une lymphoprolifération maligne à cellules T, la leucémie aiguë de l’adulte (ATL). L’oncoprotéine Tax du virus HTLV-1 joue un rôle majeur dans l’établissement de la leucémie mais aussi dans la réplication du virus. Tax régule la transcription du promoteur viral situé au sein du LTR 5’ du virus, gouvernant ainsi sa propre production. Pour ce faire, Tax recrute des dimères du facteur de transcription cellulaire CREB, sous forme phosphorylée, au niveau d’éléments de réponse à l’AMP cyclique (vCRE) situés dans
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10

Sanfilippo, Luiz Francisco. "Epidemiologia e caracterização molecular do vírus da Influenza em quatro espécies de pinguins na Região Antártica." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/42/42132/tde-11082011-105843/.

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O Vírus da influenza, apesar de todas as epidemias e pandemias referirem-se a infecções em seres humanos, não está restrita a espécie humana e é capaz de causar debilidade ou mortalidade em várias outras espécies, incluindo cavalos, suínos, mamíferos marinhos e aves, entre outros. Estudos ecológicos das viroses de influenza conduziram a hipótese que todas as que acometem mamíferos derivam de reservatórios destes vírus em aves. Mesmo com programas de monitoramento contínuo de aves silvestres em alguns países do mundo que possuem casos originados pelos vírus aviário H5N1, pouco foi feito na Antá
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11

Roehe, Paulo Michel. "Studies on the comparative virology of pestiviruses." Thesis, University of Surrey, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277503.

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12

Nguyen, Thuy. "Ultra-deep sequencing applications in virology research." Electronic Thesis or Diss., Sorbonne université, 2018. http://www.theses.fr/2018SORUS282.

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Les deux virus d’ARN VIH et VHC attirent beaucoup d’attention de la santé publique parce qu’ils partagent des mêmes facteurs de risque de transmission par le sang et par des contacts sexuels. En plus, les maladies associées aux infections par le VIH et par le VHC sont des causes principales de mortalité et de morbidité globalement. Néanmoins, grâce à l’introduction des thérapies d’antirétroviraux pour le traitement de l’infection par le VIH et les antiviraux à action directe (AADs) pour le traitement de l’infection par le VHC, les patients infectés par ces virus constatent une amélioration sig
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13

Watanabe, Aripuanã Sakurada Aranha. "Pesquisa do vírus influenza HRSV e hMPV em uma população de idosos da cidade de Botucatu - São Paulo, Brasil /." Botucatu : [s.n.], 2006. http://hdl.handle.net/11449/89984.

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Orientador: João Manuel Grisi Candeias<br>Resumo: Não disponível.<br>Abstract: From about 200 virus that cause respiratory infections, only 8 are responsible for severe illness in children, immunodeficient adults and elderly, inc1uding Adenovirus, Influenza A and B, Parainfluenza 1, 2 and 3, Human RespÍratory Syncytial Vírus (HRSV) and Human Metapneumovirus (hMPV). Three of these virus are responsible for a significant morbidity in elderly: Influenza, HRSV and hMPV. The nosocomial infection caused by these vÍruses can be fatal in hospitalized children and patients with other pathologies. With
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14

Urizarna, España María. "Identificación de posibles factores de Myzus persicae implicados en la transmisión del virus del grabado del tabaco (TEV) y estrategias para interferir su expresión." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/111229.

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En esta tesis se aborda la identificación de factores del pulgón Myzus persicae que podrían participar en el proceso de transmisión del potyvirus del grabado del tabaco, Tobacco etch virus (TEV), y se explora la posibilidad de alterar la expresión de genes particulares en el insecto vector como una manera de dificultar o impedir la diseminación de este virus. Se conoce la intervención de un factor auxiliar de origen viral, la proteína HCPro, en la transmisión de potyvirus, actuando como un puente molecular reversible para retener las partículas de virus en el aparato bucal del pulgón. La pr
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15

Jacob, Grégoire. "Malware behavioral models : bridging abstract and operational virology." Rennes 1, 2009. http://www.theses.fr/2009REN1S204.

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This thesis is devoted to the modeling of malicious behaviors inside malevolent codes, commonly called malware. The thesis work follows two directions, one operational, one theoretical. The objective is to eventually combine these two approaches in order to elaborate detection methods covering most of existing malware, while offering formal security guarantees against appearing ones. The operational approach introduces an abstract behavioral language, independent from implementation. The language itself relies on the attribute-grammar formalism, capable of expressing the behavior semantics. Wi
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16

García, Vidal Edurne. "Identification and characterization of novel latency-reversing agents to clear HIV-1 viral reservoir." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/669732.

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La terapia antirretroviral ha cambiado la perspectiva sobre la infección por VIH-1 de enfermedad letal a crónica. Aun así, el reservorio latente del VIH-1 es una de las mayores barreras para lograr una cura. La estrategia “shock and kill” se basa en inducir la transcripción viral del provirus latente del VIH-1 seguido de la muerte selectiva de las células reactivadas. Aunque muchos agentes reversores de la latencia (LRAs) han sido identificados y testados, ninguno ha logrado erradicar eficazmente dicho reservorio. Dada la necesidad de nuevos agentes y estrategias capaces de eliminar el reservo
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17

Madjo, Ursula. "Rôle de la protéine LC3C dans les mécanismes déployés par le VIH-1 pour contrer la restriction imposée par BST2/Tetherin sur la production virale." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB039.

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La protéine cellulaire BST2/Tetherin est un médiateur de l’immunité innée qui exerce son activité antivirale contre la dissémination de nombreux virus enveloppés. Ce facteur de restriction retient physiquement les virus néoformés à la surface cellulaire de la cellule infectée, empêchant ainsi le relâchement des virions du VIH-1. La protéine Vpu du VIH-1 est l’un des acteurs viraux capable de contrer cette restriction : elle diminue le niveau d’expression de BST2/Tetherin présent au site de bourgeonnement viral et restaure ainsi une production virale efficace. A ce jour, les mécanismes exacts p
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18

Nilsson, Emma C. "Cellular receptors for viruses with ocular tropism." Doctoral thesis, Umeå universitet, Virologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-42818.

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Several viruses from different virus families are known to cause ocular infections, e.g. members of the Adenoviridae, Picornaviridae and the Herpesviridae families. These infections are spread by contact and in the case of adenoviruses (Ads) and picornaviruses they are also highly contagious. The ocular infections caused by Ads and picornaviruses are called epidemic keratoconjunctivitis (EKC) and acute hemorrhagic conjunctivitis (AHC), respectively. Historically, EKC is caused mainly by three types of Ads from species D: Ad8, Ad19 and Ad37. The infection is characterized by keratitis and conju
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19

Ballagi-Pordány, András. "Application of polymerase chain reaction (PCR) in veterinary virology /." Uppsala : Sveriges lantbruksuniv, 1995. http://epsilon.slu.se/avh/1995/91-576-4997-9.gif.

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20

Fowotade, Adeola. "Molecular virology of KSHV : elucidating vIRF2 and vIRF4 function." Thesis, University of Surrey, 2017. http://epubs.surrey.ac.uk/813233/.

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The innate type I interferon antiviral response is the first line of defence invoked to limit the spread of viral infections. Hence a number of viruses including Kaposi's sarcoma-associated herpesvirus (KSHV) have evolved defence strategies against this antiviral response. KSHV is the aetiologic agent of KS and almost one quarter of the KSHV genes specify either demonstrated or potential immunomodulatory activity including the four viral interferon regulatory factors (vIRFs). vIRFs 1, 2 and 3 have previously been shown to inhibit type I IFN signalling, whereas the inhibitory role of vIRF4 is y
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21

Tongo, Passo Aime Marcel Simon. "Immunology and virology of HIV-1 infection in Cameroon." Doctoral thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/9521.

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Includes bibliographical references.<br>This study confirms the widespread existence of highly divergent HIV lineages in Cameroon. While the genetic complexity of the Cameroonian HIV-1 epidemic has potentially serious implications for the design of biomedical interventions, detailed analyses of divergent Cameroonian HIV-1 group M lineages could be crucial for dissecting the earliest evolutionary steps in the emergence of HIV-1 group M. In addition, the central nature of HIV-1 consensus M sequences resulted in their broad recognition, but failed to identify highly immunodominant peptides betwee
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22

Skog, Johan. "The quest for new improved adenovirus gene therapy vectors against glioma tumours." Doctoral thesis, Umeå : Umeå University, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-624.

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23

Zappa, Emilio. "New group theoretical methods for applications in virology and quasicrystals." Thesis, University of York, 2015. http://etheses.whiterose.ac.uk/10124/.

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Non-crystallographic symmetries are ubiquitous in physics, chemistry and biology. Prominent examples are quasicrystals, alloys with long-range order but no translational periodicity in their atomic organisation, and viruses, micro-organisms consisting of a protein shell, the capsid, that in most cases displays icosahedral symmetry. Group theory plays a crucial role in understanding their structures and their physical and geometrical properties. In this thesis new group theoretical methods are introduced, to characterise virus organisation and model structural transitions of icosahedral quasicr
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24

Sosa, Portugal Silvana Nelly. "Epidemiological surveillance of swine influenza viruses in pig farms." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670891.

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En el primer estudi de la present tesi, es van estudiar brots de malaltia respiratòria compatible amb virus de la influença de tipus A (IAV) així com granges que no mostraven simptomatologia clínica. Per a l'estudi dels brots, es van recollir mostres de hisops nasals d'animals amb signes respiratoris i febre (&#8805;40 ° C), mentre que a les granges sense simptomatologia clínica, es van recollir hisops nasals de garrins de maternitat, transició i porcs d'engreix (20 per grup). Es va estudiar un total de 211 brots i 19 granges aparentment subclíniques. La presència i llinatge es van determinar
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25

Hale, Richard. "Isolation and Genomic Characterization of 45 Novel Bacteriophages Infecting the Soil Bacterium Streptomyces griseus." Thesis, University of North Texas, 2018. https://digital.library.unt.edu/ark:/67531/metadc1404571/.

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Bacteriophages, or simply "phages," are the most abundant biological entities on the planet and are thought to be the largest untapped reservoir of available genetic information. They are also important contributors to both soil health and nutrient recycling and have significantly influenced our current understanding of molecular biology. Bacteria in the genus Streptomyces are also known to be important contributors to soil health, as well as producing a number of useful antibiotics. The genetic diversity of large (> 30) groups of other actinobacteriophages, i.e. phages infecting a few close r
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26

Li, Pui-lin Jennifer, and 李佩蓮. "Aspects of bacteriology/virology of shellfish in relation to public health." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31253799.

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27

Li, Pui-lin Jennifer. "Aspects of bacteriology/virology of shellfish in relation to public health /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B18734261.

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28

Rigo, Adrover Maria del Mar. "Acció moduladora de prebiòtics i probiòtics sobre la infecció per rotavirus en un model de rates lactants." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/400296.

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El rotavirus (RV) és el principal causant de diarrea greu en nens menors de cinc anys i, encara que es necessiten més estudis estandarditzats, hi ha evidència de que els probiòtics poden ajudar a lluitar contra el RV i contra altres patologies infeccioses i intestinals. Sobre aquesta base, l'objectiu de la present tesi va ser el d’avaluar l'efecte protector de productes relacionats amb els probiòtics i els prebiòtics contra les infeccions per rotavirus, utilitzant models experimentals en rata lactant. Per aconseguir aquest objectiu, es va utilitzar un model d’infecció simple per RV ja ex
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29

Jiménez, Melsió Alexandra. "Description of a novel species of Torque teno sus virus (TTSuV) and first insights on immunization against TTSuVs in naturally infected pigs." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/319700.

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Els anellovirus són un grup de virus de cadena senzilla d’ADN amb una elevada diversitat genètica i que infecten a vertebrats. Els Torque teno sus virus (TTSuV) son ubics i és l’espècie d’anellovirus específica que infecta els porcs. S’han descrit 3 espècies víriques diferents, anomenades TTSuV1a i TTSuV1b dins del gènere Iotatorquevirus i TTSuVk2a, dins el gènere Kappatorquevirus. Aquests virus son genèticament molt diferents (>56% de diversitat de seqüencia nucleotídica) però comparteixen la mateixa organització del genoma i estratègia d’expressió. L ‘infecció de TTSuV en porcs es caracterit
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30

Lundgren, Magnus. "Coxsackievirus B3 Infection and Host Defence Responses Change the Metabolism of PBDE." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-108849.

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It has been suggested that the rising amounts of chemicals in the environment may affect host resistance and increase susceptibility to infections. Studies have also shown that infections can change the toxicity of pollutants. The aim of this thesis was to study interactions between environmental pollutant exposure in terms of polybrominated diphenyl ethers (PBDE) and a common human coxsackievirus B3 (CVB3) infection adapted to Balb/c mice. The studies focused on virus levels, cytokines, metabolising cytochrome P450 (CYP) enzymes and tissue distribution of PBDE. A novel finding was an organ-sp
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31

Fernandez, Llenalia Garcia. "Statistical modelling of performance data for molecular amplification methods in diagnostic virology." Thesis, University of Abertay Dundee, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.650529.

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Nucleic Acid Technology (NAT), introduced in the late 90s, is a molecular amplification method that can be used for the diagnosis and management of patients with infectious diseases. NAT test results are obtained quicker and are quantified, providing great.er information than the positive/negative results available from traditional techniques. However, NATs arc technically demanding, susceptible to contamination and hence results from associated diagnostic tests may be inaccurate. External Quality Assessment (EQA) services are programmes developed to assess and advance the quality performance
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Gahleitner, Florian. "Viral induced exacerbations of childhood asthma : clinical findings, virology and cytokine responses." Thesis, University of Southampton, 2015. https://eprints.soton.ac.uk/383589/.

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Busson, Laurent. "Evolution of direct diagnostic techniques in Virology; analytical performances and clinical input." Doctoral thesis, Universite Libre de Bruxelles, 2020. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/313391.

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Le diagnostic virologique est un sujet d’actualité particulièrement du fait des récentes épidémiesou pandémies telles que la pandémie d’influenza A(H1N1) en 2009 ou la diffusion du virus Zika dansles Amériques et la région du Pacifique entre 2014 et 2017, associée à des cas de microcéphalie et dessyndromes de Guillain Barré. Encore plus récemment, en août 2018, le ministre de la santé de laRépublique Démocratique du Congo annonçait la 10e épidémie de virus Ebola dans le pays et endécembre 2019, le coronavirus SARS-CoV-2 est à l’origine d’une pandémie au départ de la Chine. Avecle nombre croiss
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34

Andersson, Emma. "Human adenoviruses : new bioassays for antiviral screening and CD46 interaction." Doctoral thesis, Umeå universitet, Virologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-35733.

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Adenoviruses are common pathogens all over the world. The majority of the population has at some point been infected with an adenovirus. Although severe disease can occur in otherwise healthy individuals an adenovirus infection is most commonly self limited in these cases. For immunocompromised individuals however, adenoviruses can be life-threatening pathogens capable of causing disseminated disease and multiple organ failure. Still there is no approved drug specific for treatment of adenovirus infections. We have addressed this using a unique whole cell viral replication reporter gene assay
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35

Xu, Ning. "Adenoviral Control of RNAi/miRNA Pathways in Human Cells." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distribution], 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9387.

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36

González-Ortega, Emmanuel. "Resistance to HIV entry inhibitors: signature mutations as tool guide for the identification of new antiviral agents." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/84059.

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There are several reasons to celebrate the latest advances in the treatment of the infection with HIV. According to the Joint United Nations Programme on HIV/AIDS, the number of new infections dropped by 15%; there is also a decrease by 22% in the number of deaths related to HIV/AIDS. Nevertheless, there are new emerging challenges, i.e. the transmission of drug-resistant HIV-1 strains. Therefore, there is a demand for the continued research for new and more potent antiretroviral agents. The entry of HIV into the cell implies a complex and well-orchestrated series of steps in which both viral
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Ariza, Sáenz Martha Rocío. "Sistemas poliméricos nanoestructurados de péptidos inhibidores del HIV-1 derivados del GB virus C (GBV-C)." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/650390.

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El uso de la terapia antiretroviral (ATR), ha sido durante décadas el tratamiento de elección utilizado en la inhibición de la propagación del VIH. La terapia ATR se centra en interrumpir las diferentes etapas del ciclo de replicación del virus en la célula susceptible de infección; sin embargo, el incumplimiento del régimen ATR por parte de los pacientes, ha facilitado la aparición de cepas multiresistentes que hacen que el virus cada vez sea más difícil de erradicar, convirtiéndose en un problema de salud pública. No obstante, nuevas estrategias basadas en el uso de las herramientas actualme
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Rizotto, Laís Santos. "Metapneumovírus aviários em aves silvestres." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-17052017-125020/.

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Metapneumovírus Aviário (aMPV), família Pneumoviridae, gênero Metapneumovírus, é o agente etiológico responsável pela rinotraqueíte dos perus e também está associada à síndrome da cabeça Inchada em galinhas, duas importantes doenças respiratórias que acometem aves comerciais e levam a grandes perdas econômicas. O objetivo deste estudo foi detectar a presença de aMPV em amostras de aves silvestres e realizar a caracterização molecular dos isolados encontrados, com o intuito maior de contribuir para o entendimento da epidemiologia desse vírus. Para isso foram coletados no total, 448 suabes orofa
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39

Pokiniewski, Katie Ann. "Understanding the cellular mechanism of Adeno-Associated Virus genome stabilization." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/385837.

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Microbiology and Immunology<br>Ph.D.<br>The Adeno-Associated Virus(AAV) is a small, single stranded DNA virus that has been developed as a gene transfer vector. Early clinical trials using recombinant AAV vectors (rAAV) have identified the following concerns that need to be addressed in order to increase efficiency of these vectors. It has since been determined that AAV vector efficiency decreases due to the following mechanisms: ineffective endocytosis, endosomal degradation, inefficient trafficking, and the need to convert from a single-stranded AAV genome to a transcriptional active double-
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Aspden, Kate. "A study of the host-restricted lumpy skin disease virus as a vaccine vector using rabies babies virus as a model." Doctoral thesis, University of Cape Town, 2002. http://hdl.handle.net/11427/2740.

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Hughes, Fiona Lesley. "Molecular investigations of subgroup I geminiviruses." Doctoral thesis, University of Cape Town, 1991. http://hdl.handle.net/11427/21979.

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Bibliography: pages 139-150.<br>The diversity of Subgroup I geminiviruses causing streak disease in maize, sugarcane, and indigenous wild grasses was investigated. The virus. isolates studied originated from maize (several southern African isolates), two sugarcane cultivars (from Natal province, South Africa, and from Mauritius), wheat, and three grasses (Panicum, Setaria, and Eleusine spp. from South Africa). The following methods were used: analysis of restriction fragment length polymorphisms (RFLPs) between viral genomes in individual infected plants; DNA cross-hybridization between virus
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42

Mbodo, Iyaloo. "Comparing high-throughput methods to measure antibody dependent cellular cytotoxicity during HIV infection." Master's thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/24300.

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The prevalence of HIV-1 is highest in Sub-Saharan Africa. Protective immune responses directed against HIV are complex and involve both cellular and humoral immunity. Based on the recent finding that the best correlate of protection against the first protective prophylactic RV144 vaccine were HIV-specific antibody responses, including those mediating natural killer (NK) cell antibody-dependent cellular cytotoxicity (ADCC), there has been considerable interest in measuring alternative roles for HIV-specific binding antibodies. The aim of this MSc dissertation was to optimise and compare two hig
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Loubser, A. S. "Genetic diversity of subtype C HIV-1 env variants in peripheral blood mononuclear cell (PBMC) DNA from infected mother-child pairs : a comparison of Heteroduplex Mobility Assay (HMA) and Base Excision Sequence Scanning (BESS) methods." Master's thesis, University of Cape Town, 2004. http://hdl.handle.net/11427/13400.

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Includes bibliographical references.<br>Immune system pressure on HIV-1 replication drives the antigenic changes seen over time. The monitoring of changes in viral sequences can provide important information on the nature of the immune response and the correlates of protection. Viral diversification may also occur due to other selective pressures such as cell availability and differences in viral fitness. Information on the genetic characteristics of HIV-1 variants present in the mother and her infected infant are useful data for establishing whether any common features exist between source in
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Nkosi, Nokwazi Pearl. "Analysis of cytomegalovirus UL97 drug resistance mutations in patients receiving Ganciclovir." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/28055.

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Introduction: Cytomegalovirus (CMV) drug resistance mutations, because of the widespread use of ganciclovir, have been widely reported in international literature, particularly in the post-transplant setting. However, a genotypic assay to detect CMV drug resistance is not available in South Africa and the prevalence of these mutations is therefore unknown. We aimed to document the prevalence and types of CMV UL97 mutations following exposure to ganciclovir in adult and paediatric oncology patients, transplant recipients and HIV-infected patients in the local tertiary level hospitals: Red Cross
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Murgia, Maria Vittoria. "STUDIES ON TURKEY PARVOVIRUSES." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1331123690.

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Khan, Aabida. "Classification of HIV virological failure using whole blood versus plasma viral load." Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/22775.

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Introduction: HIV viral load testing is the preferred monitoring approach for HIV infected patients on combination antiretroviral therapy (cART) as it is more sensitive than CD4 count and clinical monitoring. In resource limited settings, timely plasma separation and transportation to testing laboratories is a major barrier to the access of HIV viral load testing. The 2015 World Health Organisation guidelines recommend that cART should be initiated in all adults and children living with HIV regardless of disease stage or CD4 count, thereby escalating the demand for HIV viral load testing. Pote
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Quidort, Wenda Lee. "Detection and infectivity of human adenovirus in wastewater effluent, biosolids, and shellfish, and its persistence in estuarine water." W&M ScholarWorks, 2013. https://scholarworks.wm.edu/etd/1539616818.

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The United States Environmental Protection Agency (USEPA) has established the Total Coliform Rule as an indication of health risks associated with microbial contamination of drinking and ground water. In addition, the fecal coliform test is used as an indicator to reflect the suitability of use by consumers of class A biosolids. However, numerous studies have shown that bacterial indicators are not predictive of enteric viruses, such as human adenovirus (HAdV), which are much more resistant to treatment methods than bacteria. Enteric viral contamination of estuarine waters and locally-harveste
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Martin, Kayla. "Epstein-Barr Virus-Induced Oncogenesis: Epigenetic Control of LMP1 Expression and LMP1-Mediated Cell Transformation." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/400541.

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Microbiology and Immunology<br>Ph.D.<br>EBV is a human gammaherpesvirus that infects approximately 95% of the population worldwide and is associated with 1% of human cancer incidence. The EBV-genome-encoded latency membrane protein 1 (LMP1) is expressed in nearly all of EBV-associated malignancies and is the major EBV oncogene. Because LMP1 is essential for both establishing a latent EBV infection and promoting tumorigenesis, defining its role in these processes is critical in order to understand EBV-associated cancer development. Due to the importance of epigenetics in regulating EBV gene exp
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Hassan, Imad Saleh Ahmed. "A study of the immunology virology and therapy of the chronic fatigue syndrome." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391607.

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Luque, Santolaria Antoni. "Structure, Mechanical Properties, and Self-Assembly of Viral Capsids." Doctoral thesis, Universitat de Barcelona, 2011. http://hdl.handle.net/10803/31993.

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Viruses are submicroscopic biological entities that need to infect a host cell in order to replicate. In their simplest form viruses are constituted by an infective genetic material and a protein shell (the capsid) that protects the viral genome. In this thesis we try to elucidate the general physical principles playing a major role in the morphology, stability, and assembly of viral capsids. Therefore, in the first part of the thesis, we develop a general theory that characterizes spherical and bacilliform (or prolate) capsids based on icosahedral symmetry under the same geometrical framew
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