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Journal articles on the topic 'Virtual Slides'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Prunk, Tanja, Bogdan Zdravković, and Miha Munda. "comparative study of Virtual Microscopy versus Traditional Microscopy for introduction into the Histology Curriculum at a Faculty of Medicine." Acta Medico-Biotechnica 8, no. 2 (2021): 52–58. http://dx.doi.org/10.18690/actabiomed.124.

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Purpose: We currently employ traditional microscopy with glass slides for teaching purposes. Here, we performed a pilot survey on the potential implementation of virtual microscopy. Experienced peer tutors were asked to participate in the evaluation of virtual microscopy versus traditional microscopy. Our main objectives were to determine: whether there is a statistically significant difference in time to locating a structure on a glass slide versus a virtual slide, the possible advantages and disadvantages of each microscopy method, and the benefits of virtual microscopy over traditional micr

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Donnelly, Amber D., Maheswari S. Mukherjee, Elizabeth R. Lyden, and Stanley J. Radio. "Virtual microscopy in cytotechnology education: Application of knowledge from virtual to glass." CytoJournal 9 (April 30, 2012): 12. http://dx.doi.org/10.4103/1742-6413.95827.

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Background:Virtual microscopy (VM) is a technology in which the glass slides are converted into digital images. The main objective of this study is to determine if cellular morphology, learned through virtual microscopy, can be applied to glass slide screening.Materials and Methods:A total of 142 glass slides (61 teaching and 81 practice) of breast, thyroid, and lymph node fine needle aspiration body sites were scanned with a single focal plane (at 40X) using iScanCoreo Au (Ventana, Tuscan, AZ, USA, formerly known as BioImagene, California, USA). Six students including one distant student used

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Aeffner, Famke, Hibret A. Adissu, Michael C. Boyle, et al. "Digital Microscopy, Image Analysis, and Virtual Slide Repository." ILAR Journal 59, no. 1 (2018): 66–79. http://dx.doi.org/10.1093/ilar/ily007.

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Abstract Advancements in technology and digitization have ushered in novel ways of enhancing tissue-based research via digital microscopy and image analysis. Whole slide imaging scanners enable digitization of histology slides to be stored in virtual slide repositories and to be viewed via computers instead of microscopes. Easier and faster sharing of histologic images for teaching and consultation, improved storage and preservation of quality of stained slides, and annotation of features of interest in the digital slides are just a few of the advantages of this technology. Combined with the d

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Walkowski, Slawomir, and Janusz Szymas. "Histopathologic Patterns of Nervous System Tumors Based on Computer Vision Methods and Whole Slide Imaging (WSI)." Analytical Cellular Pathology 35, no. 2 (2012): 117–22. http://dx.doi.org/10.1155/2012/483525.

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Background: Making an automatic diagnosis based on virtual slides and whole slide imaging or even determining whether a case belongs to a single class, representing a specific disease, is a big challenge. In this work we focus on WHO Classification of Tumours of the Central Nervous System. We try to design a method which allows to automatically distinguish virtual slides which contain histopathologic patterns characteristic of glioblastoma – pseudopalisading necrosis and discriminate cases with neurinoma (schwannoma), which contain similar structures – palisading (Verocay bodies).Methods: Our

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Anyanwu, Godson Emeka, Augustine Uchechukwu Agu, and Ugochukwu Bond Anyaehie. "Enhancing learning objectives by use of simple virtual microscopic slides in cellular physiology and histology: impact and attitudes." Advances in Physiology Education 36, no. 2 (2012): 158–63. http://dx.doi.org/10.1152/advan.00008.2012.

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The impact and perception of students on the use of a simple, low technology-driven version of a virtual microscope in teaching and assessments in cellular physiology and histology were studied. Its impact on the time and resources of the faculty were also assessed. Simple virtual slides and conventional microscopes were used to conduct the same examinations for the same students. Students performed significantly better in the examination with the virtual slide and also showed a significantly higher preference for virtual slides. The time and cost implications of conducting examinations using

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Khalbuss, Walid E., Jackie Cuda, and Ioan C. Cucoranu. "Screening and dotting virtual slides: A new challenge for cytotechnologists." CytoJournal 10 (October 29, 2013): 22. http://dx.doi.org/10.4103/1742-6413.120790.

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Digital images are increasingly being used in cytopathology. Whole-slide imaging (WSI) is a digital imaging modality that uses computerized technology to scan and convert entire cytology glass slides into digital images that can be viewed on a digital display using the image viewer software. Digital image acquisition of cytology glass slides has improved significantly over the years due to the use of liquid-based preparations and advances in WSI scanning technology such as automatic multipoint pre-scan focus technology or z-stack scanning technology. Screening cytotechnologists are responsible

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Kim, Meekyeong, and Chu Leui Hong. "Web-Base Virtual Collaboration in E-Learning System." Applied Mechanics and Materials 284-287 (January 2013): 3459–62. http://dx.doi.org/10.4028/www.scientific.net/amm.284-287.3459.

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In this paper, we are proposing a web-based virtual collaboration system for e-learning system. We propose new multimedia presentation and recordable virtual collaboration which supports synchronized multimedia presentation using Synchronous Multimedia Integration Language (SMIL). It allows synchronization of the contents of a PowerPoint presentation file and a video file so that the presentation shows slides and video on the same topic at any given time. The resulting SMIL file is used to provide multimedia presentation for image intensive discussion. Participants can use text along with asso

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Treanor, Darren. "Virtual slides: an introduction." Diagnostic Histopathology 15, no. 2 (2009): 99–103. http://dx.doi.org/10.1016/j.mpdhp.2009.01.006.

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Wang, Yinhai, David McCleary, Ching-Wei Wang, et al. "Ultra-Fast Processing of Gigapixel Tissue MicroArray Images Using High Performance Computing." Analytical Cellular Pathology 33, no. 5-6 (2010): 271–85. http://dx.doi.org/10.1155/2010/918306.

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Background: Tissue MicroArrays (TMAs) are a valuable platform for tissue based translational research and the discovery of tissue biomarkers. The digitised TMA slides or TMA Virtual Slides, are ultra-large digital images, and can contain several hundred samples. The processing of such slides is time-consuming, bottlenecking a potentially high throughput platform.Methods: A High Performance Computing (HPC) platform for the rapid analysis of TMA virtual slides is presented in this study. Using an HP high performance cluster and a centralised dynamic load balancing approach, the simultaneous anal

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Ndiba, Patrick Mutharia, Charity Gichuki, Amos Chege, and Joshua Kibera. "Development and validation of digital medical laboratory educational platform." African Journal of Science, Technology and Social Sciences 1, no. 2 (2022): 7–10. http://dx.doi.org/10.58506/ajstss.v1i2.17.

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With the rise in whole slide scanner technology, large numbers of tissue slides are being scanned and represented and archived digitally. While digital pathology has substantial implications for telepathology, second opinions and education, there are also huge research opportunities with this new type of digital data. Accessibility to large digital repositories of tissue slides is a huge potential educational resource for medical students and pathology residents. In addition to education of medical students and residents, and clinical adoption, digital pathology has been transformative for com

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Demichelis, Francesca, Vincenzo Della Mea, Stefano Forti, Paolo Dalla Palma, and Carlo Alberto Beltrami. "Digital Storage of Glass Slides for Quality Assurance in Histopathology and Cytopathology." Journal of Telemedicine and Telecare 8, no. 3 (2002): 138–42. http://dx.doi.org/10.1177/1357633x0200800303.

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Proficiency testing programmes for measuring screening skills in pathology are mainly conducted using conventional glass microscope slides. However, the availability of robotic microscopes allows an entire conventional slide to be digitized. Our experiments have shown that, using a widely available robotized microscope and a PC, the image of a single field may be acquired in 2 s on average, including stage movements, autofocus and storage. Digitizing an entire slide, a fully automated procedure, takes up to 8 h. If the image of each field is compressed at an appropriate quality level (a compre

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Capo, Ivan, Bojana Andrejic-Visnjic, Dejan Miljkovic, et al. "Virtual microscopy in histology and pathology education at the Faculty of Medicine, University of Novi Sad." Medical review 70, no. 11-12 (2017): 371–76. http://dx.doi.org/10.2298/mpns1712371c.

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Both histology and pathology as a scientific fields and as an educational subjects have always relied on technology. In the 19th century a major breakthrough happened in certain areas related to histotechnology, so histology and pathology were rapidly developing. Technological revolution has lead to modernization of histology and pathology teaching, resulting in virtual microscopy. Advantage of virtual microscopy is an improved way of teaching and better cost-effectiveness. As a method of histology and pathology teaching, it was implemented at the Faculty of Medicine of the University of Novi

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Merino, Anna, Gabriela Gutierrez, and Jaime Garcia. "Virtual Microscopy System for Blood Morphology Evaluation and Their Applications in Hematology." Blood 112, no. 11 (2008): 4691. http://dx.doi.org/10.1182/blood.v112.11.4691.4691.

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Abstract We have explored the possibilities of a new technology for scanning peripheral blood slides converting the images to a digital slide that can be observed in a manner similar to a microscope. Objectives: To evaluate the quality of peripheral blood (PB), bone marrow (BM) and body fluids (BF) images obtained in a Digital Slide Scanner in different hematological or non hematological diseases and to analyse the useful of this System in Hematology. Material and Methods: We obtained PB samples from 13 patients with the following diagnoses: 3 acute myeloid leukemia (AML), 1 acute lymphoid leu

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Grabe, Niels, Bernd Lahrmann, Thora Pommerencke, Magnus von Knebel Doeberitz, Miriam Reuschenbach, and Nicolas Wentzensen. "A Virtual Microscopy System to Scan, Evaluate and Archive Biomarker Enhanced Cervical Cytology Slides." Analytical Cellular Pathology 32, no. 1-2 (2010): 109–19. http://dx.doi.org/10.1155/2010/312048.

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Background: Although cytological screening for cervical precancers has led to a reduction of cervical cancer incidence worldwide it is a subjective and variable method with low single-test sensitivity. New biomarkers like p16 that specifically highlight abnormal cervical cells can improve cytology performance. Virtual microscopy offers an ideal platform for assisted evaluation and archiving of biomarker-stained slides.Methods: We first performed a quantitative analysis of p16-stained slides digitized with the Hamamatsu NDP slide scanner. From the results an automated algorithm was created to r

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BOSCHERT, SHERRY. "Residents Prefer Traditional Over Virtual Slides." Skin & Allergy News 40, no. 3 (2009): 11. http://dx.doi.org/10.1016/s0037-6337(09)70054-3.

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Geer, Leah C. "All in with Google Slides: Virtual engagement and formative assessment in introductory sign language linguistics." Proceedings of the Linguistic Society of America 6, no. 2 (2021): 5103. http://dx.doi.org/10.3765/plsa.v6i2.5103.

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My goals as an instructor are to be transparent and approachable and to cultivate a community of learners. The transition to virtual instruction in Sign Language Structure and Usage presented significant challenges. I wondered how students could engage effectively with me, with each other, and with course content; how students could identify what they understood and on what they needed further instruction. To address these questions, I went all in with Google Slides to build engaging, searchable, self-paced slide presentations with built-in formative assessments. COVID-19 inspired this shift i

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Peck, Martyn, and Tony Badrick. "Virtual slides versus glass slides in external quality assurance – a review." Pathology 49 (February 2017): S82. http://dx.doi.org/10.1016/j.pathol.2016.12.222.

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Filipiak, Krystyna, Agnieszka Malińska, Dariusz Krupa, and Maciej Zabel. "Innovative Methods of Archiving, Presentation and Providing Access to Histological Sections." Advances in Cell Biology 3, no. 3 (2011): 41–53. http://dx.doi.org/10.2478/v10052-011-0003-4.

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Summary The dynamic development of technical sciences and informatics makes now possible acquisition of microscopic images of histological sections, not only using digital cameras, but also through specialized devices called scanners. The digitalized images stored in a computer storage device are called virtual slides and, together with special software, are known as virtual microscopy. The virtual slides can be analyzed on a computer screen by panoramic viewing or using a detailed image examination at higher magnification. In many research and education institutions in both the U.S. and Europ

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Oszutowska-Mazurek, Dorota, Miroslaw Parafiniuk, and Przemyslaw Mazurek. "Virtual UV Fluorescence Microscopy from Hematoxylin and Eosin Staining of Liver Images Using Deep Learning Convolutional Neural Network." Applied Sciences 10, no. 21 (2020): 7815. http://dx.doi.org/10.3390/app10217815.

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The use of UV (ultraviolet fluorescence) light in microscopy allows improving the quality of images and observation of structures that are not visible in visible spectrum. The disadvantage of this method is the degradation of microstructures in the slide due to exposure to UV light. The article examines the possibility of using a convolutional neural network to perform this type of conversion without damaging the slides. Using eosin hematoxylin stained slides, a database of image pairs was created for visible light (halogen lamp) and UV light. This database was used to train a multi–layer unid

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Almohammadi, Nawal Hamdan. "Pathology students’ perceptions of virtual learning: A case study of students in Saudi Arabia." PLOS ONE 19, no. 8 (2024): e0307150. http://dx.doi.org/10.1371/journal.pone.0307150.

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Background Pathology laboratory classes are traditionally conducted using a conventional light microscope. The Coronavirus Disease 2019 (COVID-19) pandemic and recent technological advances necessitated remote learning through online classes using virtual slides (VS) instead of glass slides (GS). Aim The purpose of this study was to gauge the perception of learning pathology using virtual slides (VS) as opposed to glass slides (GS) for medical students in Saudi Arabia. This study would help modify teaching methods with the advancement of the application of newer methods in online teaching. Met

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Burfeid-Castellanos, Andrea M., Michael Kloster, Sára Beszteri, et al. "A Digital Light Microscopic Method for Diatom Surveys Using Embedded Acid-Cleaned Samples." Water 14, no. 20 (2022): 3332. http://dx.doi.org/10.3390/w14203332.

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Diatom identification and counting by light microscopy of permanently embedded acid-cleaned silicate shells (frustules) is a fundamental method in ecological and water quality investigations. Here we present a new variant of this method based on “digital virtual slides”, and compare it to the traditional, non-digitized light microscopy workflow on freshwater samples. We analysed three replicate slides taken from six benthic samples using two methods: (1) working directly on a light microscope (the “traditional” counting method), and (2) preparing “virtual digital slides” by high-resolution sli

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Mello-Thoms, Claudia, Carlos AB Mello, Olga Medvedeva, et al. "Perceptual Analysis of the Reading of Dermatopathology Virtual Slides by Pathology Residents." Archives of Pathology & Laboratory Medicine 136, no. 5 (2012): 551–62. http://dx.doi.org/10.5858/arpa.2010-0697-oa.

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Context.—The process by which pathologists arrive at a given diagnosis—a combination of their slide exploration strategy, perceptual information gathering, and cognitive decision making—has not been thoroughly explored, and many questions remain unanswered. Objective.—To determine how pathology residents learn to diagnose inflammatory skin dermatoses, we contrasted the slide exploration strategy, perceptual capture of relevant histopathologic findings, and cognitive integration of identified features between 2 groups of residents, those who had and those who had not undergone their dermatopath

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Irshad, Muhammad, Ismail Alam Khan, Amna Sarfaraz, Sahibzadi Fatima Tariq, Hina Shabir, and Sahd Rashid. "Virtual Microscopy as an Effective Tool for Oral Pathology Teaching at Undergraduate Level." Journal of the Pakistan Dental Association 33, no. 01 (2024): 7–9. https://doi.org/10.25301/jpda.331.7.

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OBJECTIVE: Is to report the usefulness of virtual microscopy in oral pathology teaching at undergraduate level. METHODOLOGY: A cross sectional study was done at Rehman College of Dentistry, Peshawar. After a verbal informed consent 40 students of third year Bachelor of Dentistry who were present on day of data collection were included. Universal sampling technique, where all the students viewed conventional glass slides on first day followed by virtual slides of the same pathological lesions on webscope software of University of Leeds on second day. A structured questionnaire using a Likert sc

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Nikitaev, V. G., A. N. Pronichev, E. V. Polyakov, et al. "System for constructing virtual slides for cytological diagnostics." Journal of Physics: Conference Series 1189 (March 2019): 012049. http://dx.doi.org/10.1088/1742-6596/1189/1/012049.

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Teoh, Chern Zhong, and Ikhwan Mat Saad Muhamad. "HistoGuide's (Virtual Microscopy and Slides) Development and Usability." Malaysia Journal of Invention and Innovation 1, no. 14 (2022): 32. https://doi.org/10.5281/zenodo.7619937.

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HistoGuide application is a smartphone application system used by sixth-form students as virtual microscopy and slides to solve the problems of incorrect drawing and labelling, inability to apply magnification and scale, and inability to observe details in microscopic practical works. However, as a newly developed application, many still do not understand the usability of the HistoGuide application. In building a good application, one important part is good usability. Usability testing, especially in the HistoGuide application, can show users' ease and efficiency in using the system. The a

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TEOH, CHERN ZHONG, and Muhamad Ikhwan Mat Saad. "HistoGuide's (Virtual Microscopy and Slides) Development and Usability." Malaysia Journal of Invention and Innovation 1, no. 1 (2022): 14–32. https://doi.org/10.64382/mjii.v1i1.9.

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HistoGuide application is a smartphone application system used by sixth-form students as virtual microscopy and slides to solve the problems of incorrect drawing and labelling, inability to apply magnification and scale, and inability to observe details in microscopic practical works. However, as a newly developed application, many still do not understand the usability of the HistoGuide application. In building a good application, one important part is good usability. Usability testing, especially in the HistoGuide application, can show users' ease and efficiency in using the system. The autho

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Fales-Williams, A. J. "Book Review: Virtual Microscopy and Virtual Slides in Teaching, Diagnosis, and Research." Veterinary Pathology 43, no. 2 (2006): 220–21. http://dx.doi.org/10.1354/vp.43-2-220-a.

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Fontelo, Paul, John Faustorilla, Alex Gavino, and Alvin Marcelo. "Digital Pathology – Implementation Challenges in Low-Resource Countries." Analytical Cellular Pathology 35, no. 1 (2012): 31–36. http://dx.doi.org/10.1155/2012/125695.

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Background: Medical education in pathology and histology in low-resource countries face many obstacles because of equipment cost and telecommunication deficiencies. Digital Pathology may provide solutions. We report student experience to virtual slides on a local network and a remote image server.Methods: Using an iPad tablet device, fifty 3rd and 4th year medical students viewed digital pathology slides from a Web server at the National Library of Medicine and a mirror server on the local network.Results: The quality of images from both servers was found to be satisfactory, but the local serv

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Ahmed, Safina, Maryam Habib, Hania Naveed, Ghazala Mudassir, Mahwish Majid Bhatti, and Rifat Nadeem Ahmad. "Improving Medical Students’ Learning Experience of Pathology by Online Practical Sessions through Virtual Microscopy." Journal of Rawalpindi Medical College 26, no. 1 (2022): 122–27. http://dx.doi.org/10.37939/jrmc.v26i1.1824.

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ABSTRACT: Objective: To assess the impact of interactive virtual pathology slides on students’ understanding of pathological disease processes. Materials & Methods: The study was conducted at Shifa College of medicine, Islamabad. Class of 3rd year MBBS, comprising of 111 students, was divided into two groups during two teaching modules. All students received online lectures prior to practical sessions. In the first module, one group was taught virtual slides through online interactive sessions, whereas the second group was taught same set of slides, using light microscopy and g

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Kayser, K., P. Hufnagl, M. Dietel, and G. Kayser. "From virtual slides to virtual pathology institution: the future of tissue-based diagnosis?" Pathology - Research and Practice 200, no. 4 (2004): 355. http://dx.doi.org/10.1016/s0344-0338(04)80770-2.

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Thrall, Michael J., Jana L. Wimmer, and Mary R. Schwartz. "Validation of Multiple Whole Slide Imaging Scanners Based on the Guideline From the College of American Pathologists Pathology and Laboratory Quality Center." Archives of Pathology & Laboratory Medicine 139, no. 5 (2015): 656–64. http://dx.doi.org/10.5858/arpa.2014-0073-oa.

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Context Whole slide imaging (WSI) produces a virtual image that can be transmitted electronically. This technology has clinical applications in situations in which glass slides are not readily available. Objective To examine the results of a validation study performed using the draft version of the WSI clinical validation guideline recently released by the College of American Pathologists. Design Ten iScan Coreo Au scanners (Ventana Medical Systems, Tucson, Arizona) were validated, 6 with one set of 100 cases and 4 with a different set of 100 cases, for 1000 case examinations. The cases were s

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Golson, Maria L., William S. Bush та Marcela Brissova. "Automated quantification of pancreatic β-cell mass". American Journal of Physiology-Endocrinology and Metabolism 306, № 12 (2014): E1460—E1467. http://dx.doi.org/10.1152/ajpendo.00591.2013.

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β-Cell mass is a parameter commonly measured in studies of islet biology and diabetes. However, the rigorous quantification of pancreatic β-cell mass using conventional histological methods is a time-consuming process. Rapidly evolving virtual slide technology with high-resolution slide scanners and newly developed image analysis tools has the potential to transform β-cell mass measurement. To test the effectiveness and accuracy of this new approach, we assessed pancreata from normal C57Bl/6J mice and from mouse models of β-cell ablation (streptozotocin-treated mice) and β-cell hyperplasia (le

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Killam, Laura A., Justin C. McAuliffe, Stephanie A. Hutton, et al. "Cocreation of Virtual Online Poverty Simulations in Google Slides." CIN: Computers, Informatics, Nursing 40, no. 1 (2022): 1–6. http://dx.doi.org/10.1097/cin.0000000000000858.

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Booth, Mary E., Darren Treanor, Nicholas Roberts, Derek R. Magee, Valerie Speirs, and Andrew M. Hanby. "Three-dimensional reconstruction of ductal carcinomain situwith virtual slides." Histopathology 66, no. 7 (2015): 966–73. http://dx.doi.org/10.1111/his.12561.

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Nakayama, Ikunori, Tsubasa Matsumura, Akihisa Kamataki, et al. "Development of a teledermatopathology consultation system using virtual slides." Diagnostic Pathology 7, no. 1 (2012): 177. http://dx.doi.org/10.1186/1746-1596-7-177.

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Glatz-Krieger, Katharina, Dieter Glatz, and Michael J. Mihatsch. "Virtual slides: high-quality demand, physical limitations, and affordability." Human Pathology 34, no. 10 (2003): 968–74. http://dx.doi.org/10.1053/s0046-8177(03)00348-4.

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Romer, David J., Kurtis H. Yearsley, and Leona W. Ayers. "Using a modified standard microscope to generate virtual slides." Anatomical Record 272B, no. 1 (2003): 91–97. http://dx.doi.org/10.1002/ar.b.10017.

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Pagni, Fabio, Francesca Bono, Camillo Di Bella, Agostino Faravelli, and Anna Cappellini. "Virtual Surgical Pathology in Underdeveloped Countries: The Zambia Project." Archives of Pathology & Laboratory Medicine 135, no. 2 (2011): 215–19. http://dx.doi.org/10.5858/135.2.215.

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Abstract Only 1 surgical pathology laboratory is available in Zambia, a country with a population of 12 million people. Since 2004 the Italian association of pathologists Patologi Oltre Frontiera has been working to create a virtual laboratory through the use of telemedicine. The project has involved staining histologic preparations on site, with the interpretation of imaged slides performed abroad through telepathology. Starting in April 2007, all surgical specimens obtained in Mtendere Mission Hospital, Chirundu, Zambia, were submitted for microscopic examination through whole-slide scans. T

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Marchevsky, Alberto M., Yan Wan, Premi Thomas, Lalita Krishnan, Helen Evans-Simon, and Helene Haber. "Virtual Microscopy as a Tool for Proficiency Testing in Cytopathology: A Model Using Multiple Digital Images of Papanicolaou Tests." Archives of Pathology & Laboratory Medicine 127, no. 10 (2003): 1320–24. http://dx.doi.org/10.5858/2003-127-1320-vmaatf.

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Abstract Background.—Modern digital cameras can acquire images from cytologic slides at sufficient resolution to allow for digital enlargement and scrolling on a video monitor, allowing for the simulation of microscopy using a computer. Objective.—The purpose of this study was to develop a tool for proficiency testing in cytopathology using multiple digital images of Papanicolaou tests. Methods.—Nine images were photographed from each of 10 Papanicolaou tests at ×100 optical magnification, 3400 × 2300-pixel resolution, using a light microscope and a digital camera. All images from each case we

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Hitchcock, Charles L. "The Future of Telepathology for the Developing World." Archives of Pathology & Laboratory Medicine 135, no. 2 (2011): 211–14. http://dx.doi.org/10.5858/135.2.211.

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Abstract Physician shortages are acute in developing countries, where disease burden is the greatest and resources for health care are very limited. A lack of pathologists in these countries has lead to delays in diagnosis and misdiagnoses that adversely affect patient care and survival. The introduction of telepathology into countries with limited resources for health care is but one of multiple approaches that can be used to alleviate the problem. Telepathology is the electronic transmission of digital images that can be used for education and diagnostic consultation. A basic system consists

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Thomas, Alison, Wen Ng, Sarah Hill, Hasan Rizvi, and Deepti Radia. "A Virtual Microscopy Learning Platform - a High Quality, Innovative and Interactive Tool for Training Haematologists of the Future: A UK Pilot Study." Blood 124, no. 21 (2014): 4846. http://dx.doi.org/10.1182/blood.v124.21.4846.4846.

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Abstract Introduction: Virtual microscopy (VM) allows a whole slide once scanned, to be visualised, navigated and annotated at different magnifications on a digital viewing platform. Advantages for trainees are numerous; slides can be viewed simultaneously by large numbers of students or accessed remotely at the student’s time and place of preference. In the UK all Haematology trainees are required to be competent in diagnostic evaluation of blood films, bone marrow aspirates and trephines. The drive towards laboratory centralisation, increasing automation and full shift working patterns has d

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Furuya, Keizo, Toshiharu Maeda, Seiji Nakanura, and Takanori Kikuchi. "The Role of Computer-Aided 3-Dimensional Analytic Tools and Virtual Microscopy in the Investigation of Radiologic-Pathologic Correlation." Archives of Pathology & Laboratory Medicine 133, no. 6 (2009): 912–15. http://dx.doi.org/10.5858/133.6.912.

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Abstract To cope with recent advances in radiologic imaging technology, a corresponding method for pathomorphologic demonstration should be developed to promote better understanding of radiologic-pathologic correlation. We attempted to obtain gross and microscopic images by using a 3-dimensional analytic tool and virtual microscopy and to link these images with multidetector computed tomography images. Surgically resected specimens were sliced to a thickness of 3 mm, and the digital images of each slice were 3-dimensionally reconstructed with RATOC TRI/3D SRF II software. Histology slides were

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White, Marissa J., Jacqueline E. Birkness, Kevan J. Salimian, et al. "Continuing Undergraduate Pathology Medical Education in the Coronavirus Disease 2019 (COVID-19) Global Pandemic: The Johns Hopkins Virtual Surgical Pathology Clinical Elective." Archives of Pathology & Laboratory Medicine 145, no. 7 (2021): 814–20. http://dx.doi.org/10.5858/arpa.2020-0652-sa.

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Context.— In the early months of the response to the coronavirus disease 2019 (COVID-19) pandemic, the Johns Hopkins University School of Medicine (JHUSOM) (Baltimore, Maryland) leadership reached out to faculty to develop and implement virtual clinical clerkships after all in-person medical student clinical experiences were suspended. Objective.— To develop and implement a digital slide–based virtual surgical pathology (VSP) clinical elective to meet the demand for meaningful and robust virtual clinical electives in response to the temporary suspension of in-person clinical rotations at JHUSO

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Cualing, Hernani D., and Lynn C. Moscinski. "“Virtual Flow Cytometry” of Immunostained Lymphocytes on Microscopic Tissue Slides." Blood 106, no. 11 (2005): 1321. http://dx.doi.org/10.1182/blood.v106.11.1321.1321.

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Abstract A method and approach were developed for fully automated measurements of immunostained lymphocytes in tissue sections by means of digital color microscopy and patent pending advanced cell analysis. The validation data for population statistic measurements of immunostained lymphocytes in tissue sections using tissue cytometry is presented. Segmentation of a 512 x 474 RGB image and display of statistical results table took 12 to 15 seconds using in-house developed algorithms. We used a panel of 7 antibodies for validation on 14 cases of mantle cell lymphoma giving percentage positive, t

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Zhang, Shuwei, Houpu Yang, Jin Zhao, and Shu Wang. "Abstract PO5-07-05: Deep learning can diagnose axillary lymph node metastases on optical virtual histologic images in breast cancer patients during surgery." Cancer Research 84, no. 9_Supplement (2024): PO5–07–05—PO5–07–05. http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-07-05.

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Abstract Background: Reliable identification of axillary lymph node (ALN) involvement in patients with breast cancer allows for definitive axillary dissection at the time of the initial surgery, thus avoiding the need for a separate axillary surgery. However, conventional intraoperative ALN diagnostic methods are time-consuming and labor-intensive and can result in tissue destruction. Dynamic full field optical coherence tomography, also called dynamic cell imaging (DCI), has been developed and validated to offer rapid and label-free histologic approximations of metastatic and non-metastatic A

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Faas, Frank G. A., M. Cristina Avramut, Bernard M. van den Berg, A. Mieke Mommaas, Abraham J. Koster, and Raimond B. G. Ravelli. "Virtual nanoscopy: Generation of ultra-large high resolution electron microscopy maps." Journal of Cell Biology 198, no. 3 (2012): 457–69. http://dx.doi.org/10.1083/jcb.201201140.

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A key obstacle in uncovering the orchestration between molecular and cellular events is the vastly different length scales on which they occur. We describe here a methodology for ultrastructurally mapping regions of cells and tissue as large as 1 mm2 at nanometer resolution. Our approach employs standard transmission electron microscopy, rapid automated data collection, and stitching to create large virtual slides. It greatly facilitates correlative light-electron microscopy studies to relate structure and function and provides a genuine representation of ultrastructural events. The method is

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Kobayashi, Hirofumi, Michael E. Kallen, Raymond Kozikowski, et al. "Real-time, multiplexed rendering of lymphoma diagnostic panels from unstained tissue sections using virtual staining." JCO Global Oncology 9, Supplement_1 (2023): 115. http://dx.doi.org/10.1200/go.2023.9.supplement_1.115.

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115 Background: Lymphoproliferative disorders are complex, heterogeneous diseases with an ever expanding array of subtypes and variants requiring stepwise assay approach to arrive at a precise diagnosis. While extensive characterization of lesional cells and the microenvironment (TME) via immunophenotyping and genotyping remains the gold standard, a full workup may be unachievable due to limited input tissue, turnaround time pressure, or unavailability of particular markers in-house. Even when available, the interpretation of large numbers of markers by pathologists is limited by the ability t

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Jimena Medina, I., M. A. Gómez-Luque, J. Peña Amaro, I. Luque Ruiz, and M. A. Gómez-Nieto. "HistoNFC: An Innovative Tool for the Practical Teaching of Histology Using NFC Technology." Wireless Communications and Mobile Computing 2019 (February 14, 2019): 1–16. http://dx.doi.org/10.1155/2019/1291364.

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Despite the development of mobile device technology over recent years, its application in the field of teaching has not yet had a parallel development. For the past two decades teaching subjects such as histology has undergone a change in the digital use of its content and didactic methods based on Web applications, e-learning portals, etc., in which the use of high definition images enables the substitution of the light microscope for a “virtual microscope”. This paper describes a mobile device solution based on the use of Near Field Communication technology for supporting teaching in medical

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Diedisheim, Marc, Roberto Mallone, Christian Boitard та Etienne Larger. "β-cell Mass in Nondiabetic Autoantibody-Positive Subjects: An Analysis Based on the Network for Pancreatic Organ Donors Database". Journal of Clinical Endocrinology & Metabolism 101, № 4 (2016): 1390–97. http://dx.doi.org/10.1210/jc.2015-3756.

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Abstract Context: Little information is available about β-cell mass in antibody-positive (Ab+) nondiabetic subjects. Objective: We have investigated whether the publicly available virtual slides of the Network for Pancreatic Organ Donors with Diabetes (nPOD) project can be used to assess β-cell mass and distribution in nondiabetic antibody-negative (Ab−) and antibody-positive (Ab+) subjects and in patients with recent-onset type 1 diabetes (T1D). Subjects and Methods: We developed a semi-automated quantification method and applied it to 415 insulin-stained slides from 69 Ab− subjects, 101 slid

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1P., D. Baraiya 2J. M. Patel 3P. D. Vihol 4J.K. Raval 5H.C. Parmar 6S. A. Patel 7P. R. Panzade. "Digital Pathology: An Overview." Trends In Agriculture Science 3, no. 3 (2023): 148–51. https://doi.org/10.5281/zenodo.7723175.

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Digital pathology (DP) is a sub-field of pathology that focuses on data management based on information generated from digitized specimen slides. Through the use of computer-based technology, digital pathology utilizes virtual microscopy.

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