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Dissertations / Theses on the topic 'Virus de la dengue'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 October 2024

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1

Tiew, Kok-Chuan. "Dengue virus protease inhibitors." Thesis, Wichita State University, 2011. http://hdl.handle.net/10057/6117.

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Dengue virus (DENV) is a major health threat that affects 2.5 billion people, or 40% of the world’s population. However, there are no approved antiviral drugs or vaccines to treat Dengue infection. This thesis describes the design, synthesis and discovery of a new class of inhibitors of DENV NS3 protease. Structure-activity relationship studies have been carried out in order to delineate the structural elements responsible for the activity of this series of compounds. A lead compound suitable for further development has been identified.<br>Thesis (M.S.)--Wichita State University, College of Li

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2

Aravapalli, Sridhar. "Dengue virus and West Nile virus protease inhibitors." Diss., Wichita State University, 2013. http://hdl.handle.net/10057/6719.

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Dengue virus and West Nile virus are important mosquito-borne pathogens of Flaviviridae family affecting millions of people worldwide and causing a severe global healthcare threat. However, currently there are no approved effective antiviral drugs or vaccines available for the treatment of virus infection. This thesis describes the design, synthesis and discovery of two novel classes of reversible competitive inhibitors of Dengue Virus and West Nile Virus NS2B/NS3 protease. Structure-activity relationship studies have led to the identification of a low micromolar hit, which will be used in a h

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Tran, Tuan Anh. "Screening against the dengue virus polymerase." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4006.

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La dengue, une des maladies les plus largement émergents actuellement, avec 390 millions d'infections chaque année (OMS), est causée par le virus de la dengue contre lequel il n’existe pas de traitements. La protéine NS5 a un rôle important dans le cycle de réplication. Cette protéine se compose d'une méthionine S-transférase d’adénosyl en N-terminal et une ARN polymérase dépendante de l'ARN (RdRp) en C-terminal. Cette NS5 RdRp peut catalyser non seulement la synthèse du brin négatif de l'ARN, utilisé comme matrice pour synthétiser l'ARN brin plus-supplémentaire, mais aussi pour la synthèse d'

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4

He, Runtao. "Characterization of dengue virus envelope protein." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq24745.pdf.

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5

Schaar, Hilde van der. "Cell entry mechanisms of dengue virus." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2009. http://irs.ub.rug.nl/ppn/318.

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6

Thu, Hlaing Myat. "Virus diversity and the emergence of Dengue." Thesis, Queensland University of Technology, 2004. https://eprints.qut.edu.au/16081/1/Hlaing_Myat_Thu_Thesis.pdf.

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The aims of this study were to investigate the role of the diversity of dengue virus populations in changing patterns of virus transmission and disease. Prior to the commencement of this study, dengue 2 virus (DENV-2) had been associated most frequently with severe disease, so the study commenced with this serotype. Because it was not possible to quantitate diversity in the entire 11 kb of the viral genome, the study focussed on the envelope (E) gene, because the E protein is the major protein on the surface of the virion and thus might be under strong selective pressure from the host immune s

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Thu, Hlaing Myat. "Virus Diversity and the Emergence of Dengue." Queensland University of Technology, 2004. http://eprints.qut.edu.au/16081/.

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The aims of this study were to investigate the role of the diversity of dengue virus populations in changing patterns of virus transmission and disease. Prior to the commencement of this study, dengue 2 virus (DENV-2) had been associated most frequently with severe disease, so the study commenced with this serotype. Because it was not possible to quantitate diversity in the entire 11 kb of the viral genome, the study focussed on the envelope (E) gene, because the E protein is the major protein on the surface of the virion and thus might be under strong selective pressure from the host immune s

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8

Lindegren, Gunnel. "Optimisation of dengue diagnostic tools in order to increase the knowledge of the pathogenesis." Stockholm : Department of Microbiology, Karolinska Institutet, 2008. http://diss.kib.ki.se/2008/978-91-7409-129-8/.

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9

Niberon, Yann. "Hyperspectral Plasmonic Biosensor for Dengue Virus Detection." Electronic Thesis or Diss., Troyes, 2021. http://www.theses.fr/2021TROY0041.

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La résonance des plasmons de surface (SPR en anglais) est une technique utilisée pour détecter certaines liaisons chimiques spécifiques et leurs évolutions dans le temps avec une sensibilité et une spécificité élevée. L’objectif de ce projet est de proposer un biocapteur SPR en hyperspectral et compact pour détecter le virus de la dengue. Basé sur un système statique avec des réflexions sur des surfaces paraboliques et utilisant une source de lumière blanche, dans la configuration de Kretschmann il a été possible de réaliser simultanément une interrogation angulaire et spectrale pour générer u

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10

Tison, Laurence. "La dengue." Bordeaux 2, 1995. http://www.theses.fr/1995BOR2P091.

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11

Patramool, Sirilaksana. "Interactions virus (dengue)-vecteurs (aedes) et mise en évidence d'une méthode d'isolement des virus de la dengue et du chikungunya." Thesis, Montpellier 2, 2013. http://www.theses.fr/2013MON20139.

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La dengue et le chikungunya sont deux arboviroses émergentes qui sont transmises à l'homme par la piqûre de moustiques du genre Aedes. Il n'existe ni vaccin ni traitements commercialisés pour ces arboviroses. Il apparaît donc nécessaire de développer de nouvelles stratégies pour isoler les virus circulants et bloquer leur transmission. La compréhension des mécanismes mis en jeu dans les cellules des vecteurs Aedes lors d'une infection par le virus de la dengue (DENV) sont encore très peu étudiés, notamment pour les sérotypes 1 et 3. Par des analyses protéomiques de l'infection d'une lignée cel

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12

Hacker, Kari Ema De Silva Aravinda Manu. "Characterization of dengue virus interactions with host cells." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2845.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2009.<br>Title from electronic title page (viewed Jun. 4, 2010). "... in partial fulfillment of the degree of Doctor of Philosophy in the Department of Microbiology and Immunology." Discipline: Microbiology and Immunology; Department/School: Medicine.

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13

Katri, Patricia. "Modeling the Transmission Dynamics of the Dengue Virus." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/417.

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Dengue (pronounced den'guee) Fever (DF) and Dengue Hemorrhagic Fever (DHF), collectively known as "dengue," are mosquito-borne, potentially mortal, flu-like viral diseases that affect humans worldwide. Transmitted to humans by the bite of an infected mosquito, dengue is caused by any one of four serotypes, or antigen-specific viruses. In this thesis, both the spatial and temporal dynamics of dengue transmission are investigated. Different chapters present new models while building on themes of previous chapters. In Chapter 2, we explore the temporal dynamics of dengue viral transmission by

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Wangteeraprasert, Apirath. "CD8+ T-cells responses in Dengue virus infection." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/39398.

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Dengue virus, which has four serotypes, has several clinical manifestations including asymptomatic infection, a self-limiting febrile illness termed dengue fever (DF) and a severe form characterized by plasma leakage termed dengue hemorrhagic fever (DHF). The pathogenesis of DHF is not fully understood and many studies have shown that it is more prevalent during secondary infection. In addition to a mechanism termed antibody dependent enhancement (ADE), the role of T-cells in the pathogenesis of dengue also has been investigated. It has been hypothesized that upon secondary infection dengue-sp

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15

Twiddy, Sally Susanna. "The molecular epidemiology and evolution of dengue virus." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269490.

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Xu, Yongtao. "Computational design of peptide inhibitors for dengue virus." Thesis, Queen's University Belfast, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603298.

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Fusion process is known to be the initial step of viral infection and hence targeting the entry process is a promising strategy to design antiviral therapy. The self-inhibitory peptides derived from the envelope (E) proteins function to inhibit the protein-protein interactions in the membrane fusion step mediated by the viral E proteins. Thus, they have the potential to be developed into effective antiviral therapy. We developed a Monte Carlo-based computational method with the aim to identify and optimize potential peptide hits from the E proteins. Some novel peptides may inhibit the protein-

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Nguyen, Celina Tien, and Celina Tien Nguyen. "Using Bioorthogonal Chemistry for Investigating Dengue Virus Interactome." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/625109.

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A mosquito-borne virus endemic to the tropics and subtropics, dengue (DENV) is the most common arbovirus in the world. Among other obstacles, an incomplete understanding of specific host-virus protein-protein interactions (PPI) challenges the development of vaccines and antiviral therapies for DENV. Previous studies on DENV PPI depend on genetic modifications, which can be tedious and time-consuming to accomplish. Mixing the principles of chemical biology and virology, the work in this thesis aims to take advantage of chemical modifications on DENV to pull down DENV-host PPI. First, this thesi

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18

Obeysekera, Maheshi Prabodani. "Dengue Virus Infection of Human Microvascular Endothelial Cells." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/366032.

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Dengue virus (DENV) infection is an important public health problem, being globally the most highly prevalent mosquito-borne viral illness. The World Health Organization (WHO) has estimated 2.5 billion people are at risk of DENV infection and each year 50- 100 million infections are reported, with over 500,000 hospitalisations and 25,000 deaths. DENV consist of four serotypes, each of which are capable of producing a wide spectrum of syndromes varying from mild dengue fever (DF) to more severe dengue haemorrhagic fever (DHF). Vascular leakage resulting from increased micro vessel endothelial p

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Mohan, Swathi Groutas William C. "Potential inhibitors of dengue and West Nile virus proteases." Diss., The archival copy of this thesis can be found at SOAR (password protected), 2006. http://soar.wichita.edu/dspace/handle/10057/569.

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Thesis (M.S.)--Wichita State University, College of Liberal Arts and Sciences., Dept. of Chemistry.<br>"July 2006." Title from PDF title page (viewed on May 2, 2007). Thesis adviser: William C. Groutas. Includes bibliographic references (leaves 64-66).

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Flanagan, Aleksandra. "Structural and biophysical studies of antibody - Dengue virus interaction." Thesis, University of Oxford, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558310.

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Dengue virus (DENV), a member of Flaviviriade family, is a mosquito-borne human viral pathogen, causing every year more than 50 million infections, some of which can lead to dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS). It co-circulates as four serotypes. Humoral immunity plays a significant role in controlling flavivirus dissemination within an infected host. However, antibodies raised against DENV may be both protective and pathogenic, due to the phenomenon of antibody-dependent enhancement (ADE), which leads to a dramatic increase in the infection of cells bearing Fcy rec

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Romero-Vivas, Claudia Maria Elisa. "Studies on Aedes aegypti breeding sites and Dengue virus." Thesis, London School of Hygiene and Tropical Medicine (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298742.

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Chan, Ying Kai. "Interplay of Dengue Virus and the Human Immune Response." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467339.

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RIG-I is a key cytosolic sensor of many RNA viruses, including dengue virus (DV), the most significant arboviral pathogen. Upon viral RNA binding, RIG-I signals via the adaptor protein MAVS, located at mitochondria, to induce the expression of interferons (IFNs), proinflammatory cytokines and interferon-stimulated genes (ISGs), thereby establishing an antiviral state. Among the ISGs, the IFITM proteins are critical for antiviral restriction of numerous pathogenic viruses including DV by inhibiting viral entry. Here, we uncover how DV escapes RIG-I-mediated immunity. The NS3 protein of DV binds

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Misbah, Suzana. "Host cellular regulatory networks in dengue virus-human interactions." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/7330/.

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Dengue fever is one of the most important mosquito-borne diseases worldwide and is caused by infection with dengue virus (DENV). The disease is endemic in tropical and sub-tropical regions and has increased remarkably in the last few decades. At present, there is no antiviral or approved vaccine against the virus. Treatment of dengue patients is usually supportive, through oral or intravenous rehydration, or by blood transfusion for more severe dengue cases. Infection of DENV in humans and mosquitoes involves a complex interplay between the virus and host factors. This results in regulation of

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Bletchly, Cheryl. "Antigenic and structural analysis of the NS1 glycoprotein of dengue virus /." St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16420.pdf.

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Campanelli, Eliane Silveira. "O desenvolvimento de um processo de infecção do Aedes aegypti pelo vírus dengue: caracterização da interação do vírus com uma população de mosquitos autóctones." reponame:Repositório Institucional da FIOCRUZ, 2007. https://www.arca.fiocruz.br/handle/icict/4044.

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Made available in DSpace on 2012-05-07T15:26:26Z (GMT). No. of bitstreams: 2 license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) 000014.pdf: 4633907 bytes, checksum: e050111245c15d94b3a5781c3995bef4 (MD5) Previous issue date: 2007<br>(...) Este estudo analisou a competência vetorial de uma população colonizada de A. aegypti ao DENV-2 além da existência da transmissão vertical do vírus por esta população e a capacidade de transmissão vertical destas fêmeas. Fêmeas de A. aegypti foram infectadas com o DENV-2 através de alimentação oral. Para analisar se a infecção arti

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Labeau, Athena. "Identification and characterization of cellular factors required for zika virus and dengue virus infection." Thesis, Université de Paris (2019-....), 2019. http://www.theses.fr/2019UNIP7060.

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Les virus de la Dengue (DENV) et Zika (ZIKV) sont deux virus émergents transmis par des moustiques et sont responsables de pathologies sévères chez l’homme. Il n’y a actuellement aucun vaccin efficace, ni traitements antiviraux disponibles contre ces arbovirus. DENV et ZIKV sont des parasites intracellulaires obligatoires qui dépendent entièrement de leur cellule hôte pour se multiplier. Cette dépendance constitue un potentiel talon d’Achille qui pourrait être exploité dans le développement de nouvelles stratégies thérapeutiques. L’objectif général de mon travail de thèse a été de comprendre a

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Descloux, Elodie. "Dynamique moléculaire et épidémique du virus de la dengue dans différents écosystèmes." Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX20719.

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Les facteurs déterminant l’épidémiologie et la sévérité de la Dengue restent mal connus. La compréhension de la dynamique des épidémies est indispensable au management de la lutte anti-vectorielle et des futures stratégies vaccinales. Dans un premier travail, la caractérisation moléculaire de 181 souches de Dengue-1 a permis de déterminer l’origine des épidémies en Polynésie Française (2001, 2006) et d’identifier un phénomène de ré-émergence. La fixation d’une mutation (E-S222T) en période endémique pourrait refléter une adaptation du virus au moustique. A l’échelle intra-hôte, la diversité de

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Souza, Jerusa Botelho. "Investigação de dengue virus circulantes em Juiz de Fora- MG." Universidade Federal de Juiz de Fora, 2014. https://repositorio.ufjf.br/jspui/handle/ufjf/601.

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Submitted by Renata Lopes (renatasil82@gmail.com) on 2016-01-29T12:34:38Z No. of bitstreams: 1 jerusabotelhosouza.pdf: 1803631 bytes, checksum: e5453b5a95de704649e79eb74037206d (MD5)<br>Rejected by Adriana Oliveira (adriana.oliveira@ufjf.edu.br), reason: Adicionar instituição on 2016-02-01T15:45:28Z (GMT)<br>Submitted by Renata Lopes (renatasil82@gmail.com) on 2016-02-01T16:11:51Z No. of bitstreams: 1 jerusabotelhosouza.pdf: 1803631 bytes, checksum: e5453b5a95de704649e79eb74037206d (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2016-02-01T20:10:3

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Jacobs, Michael Graham. "Membrane association of dengue 2 virus non-structural protein 1." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325917.

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Li, Mingyuan, and 李明圓. "Molecular dissection of dengue virus egress : involvement of host cellular factors-KDEL receptors." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208011.

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The life cycle of enveloped viruses is a complex process relying on specific interactions with host factors that, in turn, represent potential targets for interfering with viral replication and pathogenesis. Although the molecular identity of cellular receptors involved in virion entry has been established for many viruses, few studies have investigated whether host proteins on intracellular compartments may function as receptors to facilitate viral trafficking and release from infected cells. In particular, viral-host interactions during dengue virus (DENV) egress are still poorly characteriz

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O'Neill, Shannon M. "The Effect of Changing Environmental Factors on the Resurgence of Dengue Fever and Severe Dengue." Scholarship @ Claremont, 2016. http://scholarship.claremont.edu/cmc_theses/1308.

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Throughout the early twentieth century, dengue fever was considered to be a nonthreatening illness, only infecting visitors of the tropics. However, in the last fifty years, there has been a resurgence of dengue fever; it is now considered to be the most consequential arbovirus, infecting more than 50 million people each year and leaving about half of the world's current population at risk of infection. The purpose of this thesis is to explore the various environmental factors that have contributed to the resurgence of dengue fever that has been seen in the last half century. Most notable of t

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Lo, Chung-yan Joanne, and 羅頌恩. "Characterization by electron microscopy of dengue virus egress using dengue recombinant subviral particle (RSPs) as a model." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48330115.

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Dengue is the most common mosquito-borne human disease, leading to 2.5 billion people at risk, 50-100 millions infections each year worldwide and among them, 500 000 severe dengue cases (dengue hemorrhagic fever, DHF/ dengue shock syndrome, DSS) plus more than 20 000 deaths. It can be caused by any of four dengue virus serotypes, which are antigenicly distinct and belong to the Flaviviridae family, genus Flavivirus. However, up till now there is no specific drug and vaccine against dengue. Understanding mechanisms developed by dengue virus to exploit host cells during all stages of the replic

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Duangchinda, Thaneeya. "Study of dengue virus specific T lymphocytes in Thai populations." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433253.

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Sessions, October Michael. "Dengue Virus Host Factors." Diss., 2009. http://hdl.handle.net/10161/3203.

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<p>Dengue fever and dengue hemorrhagic fever are estimated to afflict 50-100 million people annually and are caused by one of the four serotypes of dengue virus. Dengue virus is carried and transmitted to humans by mosquitoes of the Aedes genus. Given the broad geographic distribution of Aedes mosquitoes, it has been estimated that nearly half the world's population is at risk of contracting the disease. Currently, no vaccine or specific antiviral treatment is available to combat this emerging menace. </p><p>A greater understanding of how dengue virus interacts with its insect and human ho

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Lin, Po-Yin, and 林柏吟. "Expressing dengue virus 2 E protein for pseudotype formation of murine leukemia virus with dengue virus envelope." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/35241300985270384102.

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碩士<br>國立交通大學<br>生化工程研究所<br>94<br>Dengue virus (DV), a member of the family Flaviviridae, is an enveloped, single-stranded positive sense RNA virus. Dengue fever and dengue hemorrhagic fever (DF/DHF) are caused by the dengue viruses that represent a global public health problem. In the process of virus entry, the envelope protein (E protein) plays an important role. It is a glycoprotein of 495 amino acids, with a transmembrane domain at the C-terminal. The extracellular domain of E protein is thought to interact with the host cell receptor. There is no discernable change in the host cell that i

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HSIEH, MING-SHU, and 謝明澍. "Development of dengue virus detection and quantification system using dengue protease activity of dengue virus non-structural protein 3." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/4v6e9j.

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博士<br>國防醫學院<br>生命科學研究所<br>106<br>Titration of viruses is a fundamental procedure used in virology laboratories. It is especially critical for clinical studies, vaccine development, and antiviral drug screening. The gold standard methods to titrate infectious dengue virus (DENV) particles are the plaque assay and immune focus assay. Both methods are accurate but labour intensive and time consuming (requiring an incubation time of >3 days). To address these drawbacks, we designed a novel reporter system, dengue protease activity detection system (DENPADS). In live cells, DENPADS stably expressed

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Lin, Mong-Ping, and 林孟平. "THE SEROEPIDEMIOLOGY OF DENGUE VIRUS IN TONGKANG AND THE ESTABLISHMENTOF DENGUE VIRUS RAPID DIAGNOSIS SYSTEM." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/69881736811480253118.

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Chen, Chun-wei, and 陳俊瑋. "Utilizing highly conserved sequences of dengue virus envelope protein to develop efficacious dengue virus vaccines." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/02469364336245280852.

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碩士<br>國防醫學院<br>生物化學研究所<br>103<br>Dengue virus has four serotypes. Because one kind of infection by other serotypes if more serotypes viral infections, and it will produce severe symptoms. Therefore, the vaccine must be able to simultaneously neutralize the four serotypes of dengue virus to be effective against the virus. So up to now still no effective vaccine against the dengue virus. The reports found in the paper, there is a conserved sequence in dengue virus membrane protein domain II bc loop sequence(The 73 to 79 amino acids RCPTQGE). It can be induced against four serotypes of the den

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ChiChiu and 邱琦. "Study on the mechanism of dengue virus replication: the role of proteases during dengue virus replication." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/x63pgv.

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碩士<br>國立成功大學<br>醫學檢驗生物技術學系碩博士班<br>101<br>Dengue virus (DENV) infection can causes dengue fever and potentially lethal diseases such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Until now, there is no effective vaccine or therapeutic drugs that can be used specifically to block DENV replication in clinic. One of the difficulties of developing anti-DENV drugs is lacking of a suitable platform for compound selection. Thus, we constructed a sequence which contains secreted alkaline phosphatase (SEAP) and dengue NS2B-NS3 cutting site, followed by ligation with vector pEGFP-C1.

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Chang, Yu-Shan, and 張玉珊. "Identification of B-Cell Epitopes of Dengue Virus Type 2 from Dengue Virus Immunized Mouse Serum." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/54497205376407502612.

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碩士<br>國立臺灣大學<br>病理學研究所<br>91<br>Epitope mapping is important for understanding the pathogenesis of viral infectious diseases as well as for developing vaccines and diagnostic reagents. Here we used phage display, a selection technique for protein-protein interaction, to find out and detect dengue virus (DEN) serotype-specific B-cell epitopes. 4G2 monoclonal antibody which reacted with E-protein of all 4 kinds of dengue serotypes was used to purify whole virus from culture supernatant. The virues were then used as antigens to immunize mice (BALB/c) to produce dengue hyperimmunized serum. We use

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Yang, Chi-Chen, and 楊季真. "Development of Anti-Dengue Virus Drugs." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/39641496026001401867.

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博士<br>國防醫學院<br>生命科學研究所<br>99<br>Dengue virus (DENV) causes disease globally with an estimated 25 to 100 million new infections per year. At present, no effective vaccine is available and treatment is supportive. There is urgent need to develop therapeutic agents to cure this epidemic disease. The availability of lead compound screening methods deeply affects the success of antiviral drug discovery. In this thesis, I focused on the development of screening methodologies and studies of anti-dengue virus drugs, and the thesis is divided into two parts. Firstly, in order to design tools for anti-d

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Yang, Cheng-Fen, and 楊正芬. "Molecular epidemiology and pathogenesis of dengue virus and chikungunya virus." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/51954439713659220983.

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Chih-HuiKao and 高誌暉. "Generation of dengue virus neutralization single chain fragments of variable region (scFv) using dengue virus recombinant envelope protein." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/49781213701495757472.

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碩士<br>國立成功大學<br>醫學檢驗生物技術學系碩博士班<br>98<br>Dengue virus (DV) is an important mosquito-borne pathogen causing dengue fever (DF), dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) in the tropical and sub-tropical region of the world. Nearly 50% of people in over 100 contries are at risk of DV infection. The surface of DV particle is covered with 90 envelope (E) protein homodimers which contacted with host cells first and were essential for viral infection through receptor-mediated endocytosis. Each monomer of E protein consists of three domains. E protein domain I (DEI) is the central do

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Huang, Kao-Jean, and 黃國珍. "A murine model of dengue virus infection." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/41309194011486201588.

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碩士<br>國立成功大學<br>微生物暨免疫學研究所<br>86<br>Abstract. Dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) usually occurs in the late stage of dengue virus infection. The clinical symptoms of DHF/DSS are hemoconcentration, increased vasopermeability, edema, thrombocytopenia, and hypotension. These symptoms are very similar to those of early type hypersensitivity (ETH), a unique hypersensitivity in addition to the four traditional ones. Therefore, we proposed that DHF/DSS is an ETH-associated event. In this

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Chen, Wei-Chun, and 陳韋均. "Time-Lapsed Visualization of Dengue Virus Infection." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/kd6udz.

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碩士<br>國立陽明大學<br>生醫光電工程研究所<br>97<br>Recently, fluorescence microscopic techniques with temporal and spatial resolution have been rapidly progressed and widely applied for dynamic tracking of specific bio-molecules. We have established a time-lapsed fluorescence imaging system for the observation of Dengue virus (DENV) infection. Viral motion in host cells can be thought of as the diffusion of small-particle in colloid solution, we utilized a particle tracking program and statistical analysis methods to investigate the behaviors of viral diffusion and the infectious transport pathway in host cel

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Chen, Yu-Tien, and 陳煜恬. "Autoantibodies associated thrombocytopenia during dengue virus infection." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/11096656399076452964.

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碩士<br>國立成功大學<br>微生物及免疫學研究所<br>94<br>Dengue virus is an arthropod borne virus transmitted by Ades egypti and Ades albopictus. The disease spectrum after dengue virus infection includes self-limited dengue fever (DF) and more seriously life-threatening dengue hemorrhagic fever or dengue shock syndrome (DHF/DSS). Thrombocytopenia and plasma leakage are the two major characteristics of DHF/DSS. Several reasons are proposed for the cause of thrombocytopenia: megakaryocytes were suppressed in bone marrow, endothelium cells activation sequestered the adhesive platelets, and platelets were damaged and

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Weng, Tsui-Ying, and 翁翠霙. "Lactoferrin inhibits enterovirus71 and dengue virus infection." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/70343590865253079485.

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碩士<br>國立成功大學<br>醫事技術學系<br>92<br>Lactoferrin (LF) is an iron binding glycoprotein present in some biological fluids of mammals, such as milk, saliva, and mucous secretions. The well-studied function of LF is responsible for the transportation of metals in plasma. However, recent studies have revealed that LF plays an important role in non-specific immune system against many bacterial infection as well as viral agents. In this study we have investigated the antiviral activities of LF against enterovirus71 (EV71) which causes hand, food and mouth disease, pulmonary edema and encephalomyelitis as

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Sung, Tzu-Ling, and 宋紫玲. "Genetic Characterization and Quantification of Dengue Virus." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/50549644381868999415.

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碩士<br>國立臺灣大學<br>微生物學研究所<br>89<br>Dengue virus is a single-stranded positive sense RNA flavivirus that is transmitted by mosquito to human host. Probably due to the non-proofreading nature of the RNA-dependent RNA polymerase, RNA viruses are known to exist as a swarm of viruses that have slightly different genome compositions, the so-called quasispecies. Although the relationship between the degree of sequence diversity and disease severity has been reported in other RNA viruses such as human immunodeficiency virus (HIV) and hepatitis C virus (HCV), little is known about dengue virus.

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Yang, Shih-Ting, and 楊世婷. "Infection of murine cells by dengue virus." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/uqqe8p.

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碩士<br>國立成功大學<br>微生物及免疫學研究所<br>90<br>Dengue virus (DV), an arthropod-borne flavivirus, causes a febrile illness or severe hemorrhagic fever for which there is no effective antiviral treatment and no vaccine available. It is still not clearly understood which tissue cells are the natural targets of DV. In addition to monocytes/ macrophages, neuron, hepatocytes, endothelial cells, B lymphcytes and dendritic cells have also been reported as potential targets for DV. Recent studies have demonstrated two subsets of dendritic cells, monocyte-derived dendritic cells and human skin Langerhans cells are

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Snitko, Mariya. "Identifizierung neuer Dengue Virus Typ-2 Proteaseinhibitoren." Doctoral thesis, 2014. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-112502.

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Weltweit leben ca. 2,5 Mrd. Menschen im Dengue Virus Verbreitungsgebiet. Dengue Virus Infektionen führen zum Dengue Fieber und können bei Re-Infektionen mit anderen Serotypen das sog. Dengue Schocksyndrom mit einer Letalität von 10% verursachen. Momentan stehen jedoch weder Impfstoffe noch antivirale Substanzen zur Verfügung. In der vorliegenden Arbeit sollten DENV2-Proteaseinhibitoren entwickelt werden. Dazu wurde ein in vitro DENV Proteasetest etabliert, für den die DENV Protease in Bakterien exprimiert und anschließend gereinigt wurde. Mit diesem System wurden 144 Verbindungen getestet und

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