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Dissertations / Theses on the topic 'Virus particle assembly'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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1

Isherwood, Beverley Jane. "Hepatitis C virus : particle assembly and morphogenesis." Thesis, University of Glasgow, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410179.

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2

Soh, Timothy Kinshiong. "Single particle studies of vesicular stomatitis virus assembly." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17464089.

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The formation of viral particles requires the coordinated assembly of both nucleic acids and proteins. In the case of Rhabdoviruses, such as vesicular stomatitis virus (VSV), the particles display a characteristic bullet-shape. VSV virions consist of the matrix protein (M), glycoprotein (G), and viral ribonucleoprotein (RNP), which contains the nucleocapsid protein (N) coated RNA bound to the large polymerase protein (L) through the phosphoprotein (P). During assembly, these components are recruited to the plasma membrane where the viral RNP undergoes condensation by M and envelopment with G c

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3

Höfer, Chris Tina. "Influenza virus assembly." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2015. http://dx.doi.org/10.18452/17251.

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Influenza A Viren besitzen ein segmentiertes, einzelsträngiges RNA-Genom, welches in Form viraler Ribonukleoprotein (vRNP)-Komplexe verpackt ist. Während das virale Genom im Zellkern repliziert wird, finden Assemblierung und Knospung reifer Viruspartikel an der apikalen Plasmamembran statt. Für die Virusbildung müssen die einzelnen viralen Komponenten hierher gebracht werden. Während intrinsische apikale Signale der viralen Transmembranproteine bekannt sind, sind der zielgerichtete Transport und der Einbau des viralen Genoms in neuentstehende Virionen noch wenig verstanden. In dieser Arbeit wu

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4

Ziegler, Christopher Michael. "Key Virus-Host Interactions Required For Arenavirus Particle Assembly And Release." ScholarWorks @ UVM, 2017. http://scholarworks.uvm.edu/graddis/755.

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Viruses are infectious agents that must infect the cells of living organisms in order to reproduce. They have relatively simple genomes which encode few proteins but can compensate for their simplicity by hijacking components of their cellular hosts. Arenaviruses, a family of zoonotic viruses carried by rodents, encode only 4 proteins. One of these proteins, Z, is responsible for several functions during the virus life cycle including driving the formation and release of new virus particles at the plasma membrane of infected cells. Relatively little is known about how this viral protein is reg

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5

Corless, Lynsey. "The role of the host ESCRT complex in hepatitis C virus particle assembly and release." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.530841.

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6

Hughes, Mair Elisabeth. "Identification of residues in hepatitis C virus NS5A with a critical role in genome replication of particle assembly." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531528.

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7

Kern, Anika [Verfasser], and Karl Klaus [Akademischer Betreuer] Conzelmann. "Assembly and budding of Rabies Virus : the phosphoprotein as critical determinant of particle production / Anika Kern. Betreuer: Karl Klaus Conzelmann." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1031381120/34.

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8

Kern, Anika [Verfasser], and Karl-Klaus [Akademischer Betreuer] Conzelmann. "Assembly and Budding of Rabies Virus : The Phosphoprotein as Critical Determinant of Particle Production / Anika Kern. Betreuer: Karl-Klaus Conzelmann." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/102366092X/34.

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9

Boyer, Audrey. "Caractérisation de mécanismes mis en jeu lors des étapes précoces de l'assemblage des lipoviroparticules du virus de l'hépatite C." Thesis, Tours, 2015. http://www.theses.fr/2015TOUR3308/document.

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Lors d’une infection chronique, le virus de l'hépatite C (HCV) circule sous forme de lipoviroparticule (LVP) : particules hybrides associant des composants viraux (ARN, les protéines structurelles) et des composants cellulaires (apolipoprotéines, cholestérol). Au cours de ma thèse, nous nous sommes intéressés à identifier la plateforme d'assemblage du HCV, et le rôle du rassemblement des protéines virales par NS2 dans sa formation. Nous avons montré que des interactions de natures différentes sur la membrane du RE sont impliquées dans cette association protéique. Nos résultats suggèrent que de

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10

Bouter, Caroline [Verfasser], Frank Torsten [Akademischer Betreuer] Hufert, and Detlef [Akademischer Betreuer] Doenecke. "The Role of NS3 Helicase Domain in Hepatitis C Virus Particle Assembly / Caroline Bouter. Gutachter: Frank Torsten Hufert ; Detlef Doenecke. Betreuer: Frank Torsten Hufert." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2013. http://d-nb.info/1044869844/34.

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11

Bouter, Caroline Verfasser], Frank Torsten [Akademischer Betreuer] Hufert, and Detlef [Akademischer Betreuer] [Doenecke. "The Role of NS3 Helicase Domain in Hepatitis C Virus Particle Assembly / Caroline Bouter. Gutachter: Frank Torsten Hufert ; Detlef Doenecke. Betreuer: Frank Torsten Hufert." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2013. http://d-nb.info/1044869844/34.

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12

Labarde, Audrey. "Compartimentation du cycle viral du bactériophage SPP1 dans le cytoplasme de la bactérie Gram-positive Bacillus subtilis." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS156.

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Les virus bactériens (bactériophages), durant leur co-évolution avec les bactéries, ont su trouver de nombreuses voies pour détourner les machineries cellulaires dans le but de se multiplier efficacement. L’infection par le phage dès son entrée dans le cytoplasme est un bouleversement pour la bactérie en termes de ressources monopolisées à ses dépens et probablement de restructuration de l’espace cytoplasmique. Dans ce travail de thèse, l’impact de l’infection de la bactérie Gram-positive Bacillus subtilis par le bactériophage SPP1 a été étudié.La réplication de l’ADN est initiée par des proté

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13

Överby, Anna K. "Uukuniemi virus-like particles : a model system for bunyaviral assembly /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-238-5/.

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14

Denolly, Solène. "HCV assembly : from clustering of viral assembly factors to envelopment and lipidation of particles." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1085/document.

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Le virus de l'hépatite C (VHC) est détecté dans les sérums de patients infectés sous forme de particules infectieuses lipidées de très faibles densités. Le VHC est un virus enveloppé dont l'assemblage de particules virales se produit à la membrane du réticulum endoplasmique consécutivement au clivage séquentiel de sa polyprotéine et à sa maturation en protéines structurales et non structurales. Dans ce travail, nous avons cherché à mieux comprendre les mécanismes d'assemblage, d'enveloppement et de sécrétion des particules infectieuses. Dans une première étude, nous avons montré la connexion f

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15

Hanslip, Simon John. "Production and assembly of human papillomavirus virus-like particles." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614258.

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16

Roth, Jeanne-Francoise. "Regulation and assembly of the yeast Ty1 virus like particles." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301254.

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17

Garbutt, Michael. "Assembly and secretion of rubella virus-like particles in mammalian cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq22597.pdf.

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18

Tomasicchio, Michele. "Assembly of Omegatetravirus virus-like particles in the yeast Saccharomyces cerevisiae." Thesis, Rhodes University, 2008. http://hdl.handle.net/10962/d1003989.

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The Tetraviridae are a family of ss (+) RNA viruses that specifically infect lepidopteran insects. Their icosahedral capsids are non-enveloped and approximately 40 nm in diameter with T=4 quasi-equivalent symmetry. The omegatetraviruses, which are structurally the best characterised in the family, include Helicoverpa armigera stunt virus (HaSV) and Nudaurelia capensis omega virus (NwV). The omegatetravirus procapsid is composed of 240 identical copies of the capsid precursor proteins, which undergo autoproteolytic cleavage at its carboxyl-terminus generating the mature capsid protein (b) and γ

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19

Jung, Marcel-Alexander. "Entwicklung eines Produktions- und DNA-Verpackungssystems für Virus-ähnliche Partikel des humanpathogenen Papillomavirus Typ 16." [S.l. : s.n.], 2004. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB11103998.

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20

Pantua, Homer Dadios. "Requirements for Assembly and Release of Newcastle Disease Virus-Like Particles: A Dissertation." eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/242.

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The final step of paramyxovirus infection requires the assembly of viral structural components at the plasma membrane of infected cells followed by budding of virions. While the matrix (M) protein of some paramyxoviruses has been suggested to play a central role in the assembly and release of virus particles, the specific viral and host protein requirements are still unclear. Using Newcastle disease virus (NDV) as a prototype paramyxovirus, we explored the role of each of the NDV structural proteins in virion assembly and release. For these studies, we established a virus-like particle (VLP) s

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21

Alli, Zaman. "The assembly of hepatitis B virus core particles in transgenic tobacco, carrot and rice plants." Thesis, University of Ottawa (Canada), 2004. http://hdl.handle.net/10393/29072.

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The spread amongst humans of viral diseases such as acquired immunodeficiency syndrome (AIDS), hepatitis and severe acute respiratory syndrome (SARS) is alarming. A plant-based high fidelity production system is being developed with emphasis on producing antigens capable of being orally delivered to humans in plant packets. To test whether transgenic tobacco, carrot and rice plants can correctly process and assemble the hepatitis-B virus (HBV) core particle/antigen (HBcAg), they were transformed with a C-terminal truncated version of the HBcAg subunit coding sequence. Transgenic tobacco, carro

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22

Wu, Cheng. "Hybrid colloidal molecules from self-assembly of viral rod-like particles." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0133.

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Dans cette thèse, l’auto-assemblage en molécules colloïdales de virus en forme de filament, les bactériophages M13, est étudié. Comme première approche, l’affinité de la streptavidine pour la biotine ou un Strep-tag est utilisée et quantitativement comparée. Pour ce faire, des virus modifiés génétiquement, M13-AS, présentant des Strep-tag et des virus M13C7C chimiquement bioconjugués par de la biotine ont réagi via leur extrémité proximale avec des nanoparticules fonctionnalisées par de la streptavidine. Il en résulte la formation de molécules colloïdales en étoile, dont la valence ou nombre d

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23

Alam, Syed Benazir. "Study of the role of viral coat protein and host factor HSP70 homologs in the assembly and disassembly of Cucumber necrosis virus particles." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/61781.

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Virion assembly and disassembly are crucial aspects of the virus multiplication cycle, however, relatively little is known about these processes in plant viruses. While the former helps to produce multiple copies of stable infectious progeny virions, the latter is required for release of the encapsidated viral genome into a host cell for initiating new rounds of virus multiplication. In this thesis, I aimed to study Cucumber necrosis virus (CNV) particle assembly and disassembly and the role of CNV coat protein (CP) and host HSP70 homologs in these processes. It was found that CNV infection o

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24

Lohneis, Taylor Paige. "Consistent Fabrication of Ultrasmall PLGA Nanoparticles and their Potential Biomedical Applications." Thesis, Virginia Tech, 2019. http://hdl.handle.net/10919/95943.

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Nanotechnology and its potential for biomedical applications has become an area of increasing interest over the last few decades. Specifically, ultrasmall nanoparticles, ranging in size from 5 to 50 nm, are highly sought after for their physical and chemical properties and their ability to be easily transmitted though the bloodstream. By adjusting the material properties, size, surface potential, morphology, surface modifications, and more, of nanoparticles, it is possible to tailor them to a specific use in biomedical areas such as drug and gene delivery, biodetection of pathogens or proteins

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25

David, Guillaume. "Towards structural studies of Hepadnavirus subviral particles using wheat germ cell-free expression and solid-state NMR." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1336.

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Les études structurales des protéines membranaires eucaryotes sont importantes mais particulièrement difficiles à effectuer car elles nécessitent non seulement un système efficace et pratique pour produire la protéine dans une conformation native, d’une technique d’étude structurale compatible avec ce dernier. Du fait de leur modularité, les systèmes de production acellulaires in vitro sont adaptés à la production de protéines membranaires. De plus, l’amélioration de leur robustesse et de leur efficacité les rendent maintenant comme une alternative viable à l’expression cellulaire. Parmi ceux-

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26

Bouter, Caroline. "The Role of NS3 Helicase Domain in Hepatitis C Virus Particle Assembly." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-001F-837C-0.

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27

Chun-ChiehLin and 林君杰. "Apolipoprotein J is an essential host factor for hepatitis C virus particle assembly." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/a36gzd.

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博士<br>國立成功大學<br>基礎醫學研究所<br>102<br>Hepatitis C virus (HCV) infection not only induces hepatic diseases but also leads to disorder of lipid and glucose metabolism. HCV depends on lipid droplets (LDs) for viral particle assembly and very-low density lipoproteins (VLDLs) for virion egression. However, the components and locations for this process remain unidentified. Apolipoprotein J (apoJ) serves as a Golgi-resident molecular chaperone which can be upregulated by glucose, and is secreted to extracellular space along with the route of VLDLs. This study investigated the effects of apoJ on HCV life

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28

Guo, Ming-Wei, and 郭洺瑋. "Coronavirus virus-like Particle Assembly-Mapping Membrane Protein with Nucleocapsid Protein Interaction Domain." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/3zavv5.

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碩士<br>國立陽明大學<br>公共衛生研究所<br>100<br>Background: Coronavirus encodes four structural proteins, i.e. membrane (M), nucleocapsid (N), spike (S) and envelope (E). A number of studies have indicated that the M protein plays a key role in virion assembly and it can secret into medium as membrane-enveloped vesicles. M coexpression with N or E can lead to formation of virus-like particles (VLPs). Objective: This study aims to map the domain functionally involved in severe acute respiratory syndrome coronavirus (SARS-CoV) M and human coronavirus 229E (HCoV-229E) M self-assembly and M-N interaction. Meth

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29

Chou, Tin-An, and 周庭安. "Effects of human immunodeficiency virus type 1 protease (PR) upstream domains mutations on virus-like particle assembly and processing." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/36074133204046153305.

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碩士<br>國立陽明大學<br>公共衛生研究所<br>101<br>HIV-1 protease (PR) is encoded by pol, which is initially translated as a Pr160gag-pol polyprotein by a ribosomal frameshift event. Pr160gag-pol is incorporated into virions via interactions with assembling Pr55gag. The PR-mediated proteolytic cleavage of Pr55gag and Pr160gag-pol, known as virus maturation, is essential for the acquisition of viral infectivity. Within the Gag-Pol, the p6gag is truncated and is replaced by a transframe domain referred to as p6* or p6pol. Removal of p6pol improves Gag-Pol autoprocessing, suggesting that p6pol is involved in regu

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30

Huang, Yu Hung, and 黃鈺宏. "Investigation of the major and minor structural proteins, VP1 and VP2, of human JC virus in virus particle assembly." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/78225698750089737853.

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碩士<br>中山醫學院<br>醫學研究所<br>89<br>Abstract The human polyomavirus, JC virus, contains three capsid proteins, VP1, VP2, VP3 and a viral minichromosome. Interactions of these three capsid proteins for virus assembly are not well understood. In the current study, the major capsid protein VP1 and minor capsid protein VP2 of JC virus, have been cloned and expressed in yeast cells. Yeast expression system was employed to co-express VP1 and VP2 proteins for facilitating understanding the function of minor structural protein VP2. When VP1 and VP2 gene were co-transformed into yeast cells, both

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31

Chua, Chian New, and 蔡倩妞. "Self-assembly of nano-particle by infectious bursal disease virus VP2 structural protein in Escherichia coli." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/22085321168690260966.

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碩士<br>國立中興大學<br>農業生物科技學研究所<br>90<br>Abstract Gene encoding a structural protein (VP2) of infectious bursal disease virus (IBDV) was cloned and expressed using the host, Escherichia coli (E. coli), to investigate its capability of the formation of particulate structure. Although the previous attempt to produce unfused VP2 in E. coli was reported to be unsuccessful, in this report, the soluble E. coli-derived rVP2 (erVP2) proteins were found to form particles of approximately 20 nm in diameter. Those particles were partially purified employing CsCl density gradient ultracentrifugation

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32

Lee, Cheng-Chung, and 李政忠. "Studies of Virus Structure and Antiviral Strategies: (1) Crystal Structure of Infectious Bursal Disease Virus VP2 Subviral Particle at 2.6 Å Resolution: Implications in Virion Assembly and Immunogenicity (2) Structural Basis of Metal-conjugated Comp." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/65174589540798115706.

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博士<br>國立陽明大學<br>生化暨分子生物研究所<br>96<br>Crystal Structure of Infectious Bursal Disease Virus VP2 Subviral Particle at 2.6 Å Resolution: Implications in Virion Assembly and Immunogenicity Abstract Infectious bursal disease virus (IBDV) is responsible for the hightly contagious and immunosuppressive disease in young chicken. The structural protein VP2 of IBDV spontaneously forms a dodecahedral T=1 subviral particle (SVP), and is a primary immunogen of the virus, understand of its structure is efficient for vaccine development. In this study, the structure of IBDV SVP was determined in a cubic cryst

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33

Hsieh, Min-Yen, and 謝旻諺. "In Vitro assembly of Bamboo mosaic virus chimeric coat protein into virus-like particles." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/52220289533079936966.

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碩士<br>國立中興大學<br>生物科技學研究所<br>103<br>Foot-and-mouth disease virus (FMDV) is the causative agent of the acute and highly contagious foot and mouth disease (FMD). The symptoms are blisters on the skin of foot and mouth. FMD affects the developing of livestock industry significantly and causes the economic loss around the world. Conventional FMD vaccines are based on the chemically inactivated virus, which induce neutralizing antibodies, control disease and protect from FMD infection. However, the disadvantage of incompletely inactivated vaccine would contain live viral residues causing outbreak of

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34

Wu, Yi-min, and 吳逸民. "The Studies on assembly of Dragon Grouper Nervous Necrosis Virus and virus-like particles." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/3dwtk7.

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博士<br>國立中山大學<br>海洋資源學系研究所<br>96<br>Piscine nodaviruses are members of genus Betanodavirus, which infect more than 30 species of fish and cause massive mortality in larvae and juveniles. The infection causes great economic losses to aquaculture and sea-ranching. To study the dissociation and reassembly of betanodavirus, virus-like particles (VLPs) of dragon grouper nervous necrosis virus (DGNNV) were used. The experiments with calcium-chelating or reducing/oxidizing reagents elicited that the DGNNV VLPs required only calcium for particle assembly. With the recombinant VLPs, site-directed mutage

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35

Lee, Meng-Shiou, and 李孟修. "Functional Characterization of VPX protein and Polyprotein of Avian Infectious Bursal Disease Virus (IBDV) on Virus-like Particles Assembly and Proteolytical Cleavage in Insect Cells." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/74329720715264474129.

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博士<br>國立中興大學<br>生物科技學研究所<br>92<br>VP2 is a major structural protein of infectious bursal disease virus(IBDV). It has been demonstrated as the major host-protective immunogen of IBDV and contains the antigenic regions responsible for eliciting the virus neutralizing antibodies in the host. In this study, the precursor protein (VPX) of infectious bursal disease virus (IBDV) host immunogen VP2 protein was expressed in insect cells, including Sf9 and Hi-5 cells, to examine its regenerated particle types and the immunogenicity induced by those particles. Since the expressed protein, VPXH, was engin

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36

Wang, Kuei-Chun, and 王貴君. "Baculovirus as a highly efficient gene delivery vector for the assembly of hepatitis delta virus-like particles in mammalian cells." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/83s87r.

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碩士<br>國立清華大學<br>分子與細胞生物研究所<br>92<br>ABSTRACT Baculovirus has been employed as an efficient gene delivery vector into mammalian cells for a variety of purposes. In this study, we further expanded the applications of baculovirus as a tool to study the assembly of hepatitis delta virus-like particle. To this end, two recombinant baculoviruses were constructed to express large hepatitis delta antigen and hepatitis B surface antigen under the regulation of mammalian promoters. Simple and efficient gene transduction into hepatoma cell lines (80-90% as determined by flow cytometry) and high level tr

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