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Dissertations / Theses on the topic 'Virus replication'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Thomas, C. M. "Cauliflower mosaic virus DNA replication." Thesis, Bucks New University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374828.

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2

Ekström, Jens-Ola. "Ljungan Virus Replication in Cell Culture." Doctoral thesis, Högskolan i Kalmar, Naturvetenskapliga institutionen, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-10.

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Ljungan virus (LV) is a recently identified picornavirus of the genus Parechovirus. LV has been isolated from voles trapped in Sweden and also in the United States. LV infected small rodents may suffer from diabetes type 1 and type 2 like symptoms, myocarditis and encephalitis. LV has been proposed as a human pathogen, with indications of causing diabetes type 1, myocarditis and intrauterine fetal deaths. In this thesis, cell culture adapted LV strains were utilised for development and adaptation of several basic methodological protocols to study the LV biology, e.g. real time PCR, highly spec

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3

Ekström, Jens-Ola. "Ljungan virus replication in cell culture /." Kalmar : University of Kalmar, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-10.

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4

McQuillin, Andrew. "Aspects of cucumber mosaic virus replication." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321682.

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5

Evans, Elizabeth Van Amburg. "Molecular genetic analysis of a vaccinia virus gene with an essential role in DNA replication /." Access full-text from WCMC, 1989. http://proquest.umi.com/pqdweb?did=744576211&sid=1&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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6

Nayak, Arabinda. "Foot and mouth disease virus RNA replication." Thesis, University of Surrey, 2005. http://epubs.surrey.ac.uk/842873/.

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Infection of susceptible cells with foot and mouth disease virus (FMDV) results in multiplication of the RNA genome and assembly of mature virions. The entire process of genome replication is completed in a few hours and encompasses many intracellular events. Like other picornaviruses, FMDV uses a peptide primed RNA replication mechanism. The factors that are required to uridylylate each of the three FMDV VPg peptides and the role of the FMDV cis-acting replication element (cre) or 3B Uridylylation Site (bus) in VPg uridylylation have been determined. The native N-terminus of the FMDV 3Dpol en

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7

Szemiel, Agnieszka M. "Replication of Bunyamwera virus in mosquito cells." Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/2570.

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The Bunyaviridae family is one of the largest among RNA viruses, comprising more than 350 serologically distinct viruses. The family is classified into five genera, Orthobunyavirus, Hantavirus, Nairovirus, Phlebovirus, and Tospovirus. Orthobunyaviruses, nairoviruses and phleboviruses are maintained in nature by a propagative cycle involving blood-feeding arthropods and susceptible vertebrate hosts. Like most arthropod-borne viruses, bunyavirus replication causes little damage to the vector, whereas infection of the mammalian host may lead to death. This situation is mimicked in the laboratory:

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8

Napoli, Andrea. "Glycerophospholipid fluorescence imaging during vaccinia virus replication." Thesis, Sorbonne Paris Cité, 2019. https://theses.md.univ-paris-diderot.fr/NAPOLI_Andrea_1_va_20190415.pdf.

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Le virus de la vaccine (VACV) est l'organisme modèle pour l'étude des Poxviridae. Son cycle de réplication dans le cytoplasme de la cellule hôte a été largement étudié par microscopie optique et microscopie électronique. Grâce à des études génétiques approfondies, le rôle de certaines des 250 protéines du virus a été élucidé. Cependant, les mécanismes d’acquisition de la membrane du virus, notamment le rôle des lipides cellulaires impliqués, restent mal connus. L’étude de la composition des membranes de VACV purifiés par spectrométrie de masse a montré qu’elles présentent un enrichissement en

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9

Lu, Jia. "Norovirus translation and replication." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/278610.

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Human norovirus (HuNoV) is the leading cause of gastroenteritis worldwide. Despite the significant disease and economic burden, currently there are no licensed vaccines or antivirals. The understanding of norovirus biology has been hampered by the inability to cultivate HuNoV in cell culture. To establish a tissue culture system, infectious HuNoVs were purified from clinical stool samples. HuNoV replication was tested in different cell types. The B-cell and intestinal organoids culture systems were validated. In addition, using organoids culture a DNA-based reverse genetic system was shown to

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10

Xing, Xuekun. "DNA replication and telomere resolution in vaccinia virus." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq23557.pdf.

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11

Bao, Yiming. "The DNA replication of rice tungro bacilliform virus." Thesis, University of East Anglia, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386295.

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12

Frampton, Nicholas Ross. "Impact of hypoxia on hepatitis B virus replication." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8467/.

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Hepatitis B virus (HBV) is one of the world’s unconquered diseases, with 370 million chronically infected globally. HBV replicates in hepatocytes within the liver that exist under a range of oxygen tensions from 11% in the peri-portal area to 3% in the peri-central lobules. HBV transgenic mice show a zonal pattern of' viral antigen with expression in the peri-central areas supporting a hypothesis that low oxygen regulates HBV replication. We investigated this hypothesis using a recently developed in vitro model system that supports HBV replication. We demonstrate that low oxygen significantly

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13

Nilsson, Benjamin Erik. "Viral and host factors regulating influenza virus replication." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:b8953952-e6d5-4f6d-a7ba-cd55277611d1.

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Avian influenza A viruses typically do not replicate very efficiently when exposed to a mammalian host species. One of the reasons for this is the low activity of the viral RNA-dependent RNA polymerase of avian influenza viruses in mammalian cells. This host restrictive effect can be overcome by adaptive mutations in the avian polymerase, many of which are found in the 627-domain of the PB2 polymerase subunit. Deletion of the 627-domain revealed that this domain is not required for enzymatic functions of the polymerase in vitro, but that it essential for viral replication in a cellular environ

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14

Pina, Mery. "Replication of extrachromosomal elements of hyperthermophilic archaea." Paris 6, 2011. http://www.theses.fr/2011PA066557.

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La réplication des éléments extrachromosomales des Crenarchaeota est un sujet qui reste inconnu. Plus de 96% des ORFs virales n’ont pas des homologues dans des basses des données publiques et donc leurs fonctions ne peuvent pas être prédites par similarité de séquences. L’objectif de cet étude a été de comprendre les mécanismes de réplication des éléments extrachromosomales chez les Crenarchaea dans l’exemple du génome linaire du virus filamenteux d’Acidianus 1 (AFV1) qu’infecte Acidianus hospitalis, et celle du plasmide pRN1 de Sulfolobus islandicus. En utilisant l’analyse in silico de la séq

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15

Kandpal, Manish. "Role of defective hepatitis B virus in wild-type hepatitis B virus replication." Thesis, IIT Delhi, 2017. http://localhost:8080/xmlui/handle/12345678/7247.

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16

Penzes, Zoltan. "Defective replicating RNAs of coronavirus infectious bronchitis virus : investigation of replication and genome packaging signals." Thesis, University of Hertfordshire, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283879.

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17

Rozen-Gagnon, Kathryn. "Chikungunya virus nonstructural proteins regulate replication fidelity and pathogenicity in vivo." Paris 7, 2014. http://www.theses.fr/2014PA077199.

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Le virus Chikungunya (CHIKV) est un arbovirus ré-émergent mais aussi l'alphavirus le plus responsable de maladie humaine. La réplication de CHIKV est assujettie d'erreurs ; c'est une caractéristique de tous les virus à ARN, qui présentent les taux de mutation les plus élevés de la nature. Par conséquent, un seul virus génère des millions de descendance virale qui portent de mutations distinctes dans leurs génomes. Ces populations peuvent être décrites comme une quasi-espèce, car la population agira comme (quasi) une unité d'évolution unique (espèces). La diversité de la population virale a des

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18

Fodor, Ervin. "Studies on the vRNA promoter of influenza A virus." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294232.

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19

Kabdulov, Timur O. "Mechanisms of retroviral replication." Morgantown, W. Va. : [West Virginia University Libraries], 2001. https://etd.wvu.edu/etd/controller.jsp?moduleName=documentdata&jsp%5FetdId=2256.

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20

Molin, Ylva. "Arsenic Influences Virus Replication in Experimental Coxsackievirus B3 Infection." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-112049.

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21

Basak, Sanjukta. "Studies of Hepatitis C virus immunology : translation and replication." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97903.

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Hepatitis C virus (HCV) has become a worldwide problem. Roughly 3% of world population are estimated to be infected with the virus, producing high rates of progressive liver disease, leading to cirrhosis and hepatocellular carcinoma. The present therapy, a combined administration of pegylated interferon-alpha (IFN) and ribavirin is costly and only successful in 50% of patients infected with HCV. It is also associated with serious side effects. Thus, there is an urgent need for better tolerated and more effective treatment modalities. A therapeutic vaccine may be the solution.<br>Recent efforts

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22

Cotton, Sophie. "Characterization and movement of turnip mosaic virus replication complexes." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86558.

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Viruses are intracellular pathogens that use the host cell to produce new infectious progeny. For all positive-strand RNA viruses that have been investigated so far, viral replication takes place in cytoplasmic virus-induced membrane structures. For turnip mosaic virus (TuMV), the generation of vesicles likely associated with the replication complex depends on the synthesis of the viral protein 6K. To further characterize the vesicles formed during TuMV infection, Nicotiana benthamiana plants were agroinfiltrated with a TuMV infectious clone expressing 6K protein fused to GFP. Using confoc

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23

Stirling, Julie M. "Studies on the replication and assembly of bluetongue virus." Thesis, University of Reading, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362312.

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24

Mioulet, Valerie. "Analysis of transcription and replication signals in rinderpest virus." Thesis, University of Hertfordshire, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323458.

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25

Patel, Hershna. "Evolutionary targeted discovery of influenza A virus replication inhibitors." Thesis, University of Hertfordshire, 2017. http://hdl.handle.net/2299/19623.

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Influenza A is one of the most prevalent and significant viral infections worldwide, resulting in annual epidemics and occasional pandemics. Upon infection, antiviral drugs targeting the neuraminidase protein and M2 protein are the only treatment options available. However, the emergence of antiviral drug resistance is concerning, therefore the aim of this work was to identify inhibitor molecules that may bind to highly conserved regions of selected internal influenza A proteins. Sequences of the non-structural protein 1 (NS1), nuclear export protein (NEP) and polymerase basic protein 2 (PB2)

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26

Berthold, François. "Grapevine fanleaf virus replication : viral proteins and host factors." Strasbourg, 2015. http://www.theses.fr/2015STRAJ086.

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27

Stoner, Terri Dorene. "Indole-3-Carbinol Inhibition of Herpes Simplex Virus Replication." Kent State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=kent1228328838.

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28

Baillie, Andrew James. "Cellular and viral determinants for hepatitis C virus replication." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/6865.

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The recent discovery of an HCV isolate which replicates in cell culture has opened up opportunities to study the full viral life cycle in vitro. This genotype 2a isolate (JFH-1) and its derivatives are the only ones known to replicate efficiently in cell culture, and recent work has indicated that viral determinants for efficient replication may lie in the non-structural protein coding region of the genome. In this thesis chimaeric JFH-1 virus containing full length NS3, NS3 helicase and NS3 protease sequences from genotype 1a and 1b were constructed. The replication efficiencies of chimaeric

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29

Rosskopf, John J. "CIS-acting signals for replication of Nodamura virus RNA1." To access this resource online via ProQuest Dissertations and Theses @ UTEP, 2009. http://0-proquest.umi.com.lib.utep.edu/login?COPT=REJTPTU0YmImSU5UPTAmVkVSPTI=&clientId=2515.

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30

Clark, Hayley. "The effect of iron on hepatitis C virus replication." Thesis, Clark, Hayley (2011) The effect of iron on hepatitis C virus replication. Honours thesis, Murdoch University, 2011. https://researchrepository.murdoch.edu.au/id/eprint/7179/.

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Hepatitis C virus (HCV) is a small RNA encoded virus that causes acute and chronic infections of the liver and is associated with fibrosis, cirrhosis, hepatocellular carcinoma and end-stage liver disease. The infection is linked with elevated serum ferritin levels and iron deposits within the liver which are associated with an increased risk of progression of HCV disease. It is hypothesised firstly that the presence of excess iron affects HCV replication and secondly that iron homeostasis is altered by HCV replication. The main aim of this study was to investigate the influence of iron on HCV

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31

Piccininni, Sabina. "Structure and function of Hepatitis C virus replication complex." Thesis, University of Manchester, 2004. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.488274.

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32

Hafner, Gregory. "Replication of banana bunchy top virus : mechanisms and interference." Thesis, Queensland University of Technology, 1998.

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33

Dirks, Clarissa A. "The role of cellular factors in retrovirus replication /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/5072.

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34

駱淑芳 and Suk-fong Anna Lok. "Replication of hepatitis B virus in Chinese patients with chronic hepatitis B virus infection." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1990. http://hub.hku.hk/bib/B31981392.

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35

Brett, Katharina. "Molecular requirements of influenza virus hemagglutinin for site-specific S-acylation and virus replication." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2015. http://dx.doi.org/10.18452/17274.

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Das Hämagglutinin (HA) des Influenzavirus ist post-translational durch S-Acylierung von drei Cysteinen modifiziert. Zwei davon befinden sich in seiner zytoplasmatischen Domäne (CD) und enthalten Palmitat und eines am Cytosol-zugewandten Ende der Transmembranregion (TMR) wird bevorzugt mit Stearat acyliert. Es wird vermutet, dass entweder die Aminosäureumgebung der Acylierungsstelle oder dessen Lage relativ zur Membran bestimmt welcher Fettsäuretyp angeheftet wird. Diese Acylierungstellen sind zudem essentiell für die Virusreplikation. Ob auch andere Aminosäuren der CD essentiell sind, ist nich

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36

Najmabadi, Hossein. "Characterization of the Self-Replicating Kirsten Murine Leukemia Viral DNA: Replication and Tetracycline Resistance." Thesis, University of North Texas, 1989. https://digital.library.unt.edu/ark:/67531/metadc798479/.

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This research project deals with the characterization of self-replicating Kirsten murine viral DNA. The replication of this viral DNA and tetracycline resistance conferred to bacteria by this viral DNA will be studied. The restriction endonuclease and Southern blot analysis revealed a fragment of pBR322 from the Hind III and Pst I site that is located in the 3' end of the MLV-K:E molecule. Single stranded sequencing of the two terminal ends of this fragment verified that the 3' end of MLV-K:E contains identical sequence homology to pBR322. The presence of this pBR322 fragment explains the unus

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37

Roy, Dominic. "Improving the Delivery and Replication of Oncolytic Viruses." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35227.

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The optimal route for clinical delivery of oncolytic viruses (OVs) is thought to be intravenous (IV) injection; however, the immune system is armed with several highly efficient mechanisms to remove pathogens from the circulatory system. To overcome the challenges in trying to deliver OVs IV, cell carriers have been investigated to determine their suitability as delivery vehicles for systemic administration of OVs. Here we demonstrate the utility of a Drosophila melanogaster cell platform for the production and in vivo delivery of multi-gene biotherapeutic systems. We show that cultured Drosop

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38

Morgan, Rachel E. "Is the Cytoskeleton Necessary for Viral Replication?" Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/biology_theses/38.

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The cytoskeleton plays an important role in trafficking proteins and other macromolecular moieties throughout the cell. Viruses have been thought to depend heavily on the cytoskeleton for their replication cycles. However, studies, including one in our lab, found that some viruses are not inhibited by anti-microtubule drugs. This study was undertaken to evaluate the replication of viruses from several families in the presence of cytoskeleton-inhibiting drugs and to examine the intracellular localization of the proteins of one of these viruses, Sindbis virus, to test the hypothesis that alterna

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39

MAENO, KOICHIRO. "Replication of Influenza B Virus: Biological Functions of Viral Neuraminidase." Nagoya University School of Medicine, 1994. http://hdl.handle.net/2237/15935.

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40

au, M. Stewart@murdoch edu, and Meredith Stewart. "An investigation into aspects of the replication of Jembrana disease virus." Murdoch University, 2005. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20051222.104106.

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Jembrana disease virus (JDV) is an acutely pathogenic lentivirus affecting Bali cattle in Indonesia. The inability to propagate the virus in vitro has made it difficult to quantitate JDV and determine the kinetics of virus replication during the acute disease process. Reported for the first time are 2 techniques that enable quantification of the virus, and the use of these techniques to quantify the virus load in plasma of cattle during the acute disease process. The 2 techniques were a qualitative one-step JDV real-time reverse-transcription polymerase chain reaction (qRT-PCR) assay for the d

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41

Huang, Jianhe. "Molecular dissection of the Spodoptera littoralis nucleopolyhedrovirus : virus-host cell interaction and virus DNA replication." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0008/NQ52762.pdf.

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42

Horscroft, Nigel John. "Orbivirus non-structural protein NS2 : its role in virus replication." Thesis, University of Oxford, 1997. http://ora.ox.ac.uk/objects/uuid:9b550db6-dd9d-4127-941f-93eab2b6e038.

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43

Gowans, E. J. "Studies on markers of hepatitis B virus replication in man /." Title page, contents and summary only, 1986. http://web4.library.adelaide.edu.au/theses/09PH/09phg722.pdf.

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44

Shaw, Andrew Edward. "The Role of Non-Structural Proteins in Bluetongue Virus Replication." Thesis, University College London (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519459.

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45

Escaler, Margarita. "Changes in host gene expression associated with plant virus replication." Thesis, University of East Anglia, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302215.

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46

Hofer, Julie M. I. "Regulation of gene expression and replication in wheat dwarf virus." Thesis, University of East Anglia, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334331.

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47

Desmond, Elizabeth. "The interference of influenza virus replication by subgenomic ribonucleic acid." Thesis, University of Reading, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339508.

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48

Abdulsattar, Ban Oday. "Coronavirus proteins and their directed evolution to inhibit virus replication." Thesis, University of Reading, 2017. http://centaur.reading.ac.uk/73736/.

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Coronaviruses are enveloped, positive sense, RNA viruses that infect many species of animals, including humans. Of the six coronaviruses that can infect humans, SARS-CoV and MERS-CoV are the etiological agents of most concern currently. Coronaviruses possess the most complex and largest RNA genomes among all RNA viruses. The genome contains up to 15 genes with multiple open reading frames (ORFs) encoding both structural and non-structural proteins. Coronaviruses encode about 30 proteins that play specific, and often essential, roles in viral replication and assembly. This thesis presents work

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49

Dewar, Rebecca Amy. "Targeting cellular nuclear export to inhibit influenza A virus replication." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31349.

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Influenza A virus (IAV) is a global health threat, causing seasonal epidemics and potential pandemics leading to morbidity, death and economic losses. Currently, there are two main classes of licensed antivirals against IAV available in the US and Europe; adamantanes and neuraminidase inhibitors, both of which are hindered by the generation of resistant virus variants. The viral polymerase has a high error rate leading to mutations that allow the virus to overcome selection pressures directed at its own genome from conventional antivirals. The prospect of inhibiting host proteins that the viru

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50

Willment, Janet Anne. "Investigations of the molecular determinants of maize streak virus replication." Doctoral thesis, University of Cape Town, 1999. http://hdl.handle.net/11427/9869.

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Includes bibliographical references.<br>Geminiviruses replicate via a rolling circle mechanism, which initiates at the origin of replication located within the long intergenic region (LIR). The viral replication associated-protein (Rep) in conjunction with the host's DNA replication machinery is responsible for the initiation and termination of the replication cycle from a stem-loop structure, located within the LIR and conserved throughout the three genera of Geminiviridae. The specific interaction between the Rep protein with sequences within the intergenic region has been well characterised

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