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Journal articles on the topic 'Viscoelastic haemostatic assays'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Bates, Alexander, Andrew Donohue, James McCullough, and James Winearls. "Viscoelastic haemostatic assays in aeromedical transport." Emergency Medicine Australasia 32, no. 5 (2020): 786–92. http://dx.doi.org/10.1111/1742-6723.13510.

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WINSTEDT, DAG. "Viscoelastic haemostatic assays and fibrinogen concentration tests during haemodilution." Acta Anaesthesiologica Scandinavica 59, no. 4 (2015): 544–45. http://dx.doi.org/10.1111/aas.12478.

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Kristobak, BenjaminM, MargaretL McCarthy, RyanJ Keneally, KeithD Amberman, HarveyJ Ellis, and RobertC Call. "Citrate does not change viscoelastic haemostatic assays after cardiopulmonary bypass." Annals of Cardiac Anaesthesia 25, no. 4 (2022): 453. http://dx.doi.org/10.4103/aca.aca_34_21.

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Curry, Nicola S., Ross Davenport, Sue Pavord, et al. "The use of viscoelastic haemostatic assays in the management of major bleeding." British Journal of Haematology 182, no. 6 (2018): 789–806. http://dx.doi.org/10.1111/bjh.15524.

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Maconachie, Sharon, Melanie Jansen, Emma Cottle, et al. "Viscoelastic haemostatic assays and fibrinogen in paediatric acute traumatic coagulopathy: A comprehensive review." Emergency Medicine Australasia 32, no. 2 (2020): 313–19. http://dx.doi.org/10.1111/1742-6723.13484.

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Niemann, Marcel, Ellen Otto, Christian Eder, Yasmin Youssef, Lutz Kaufner, and Sven Märdian. "Coagulopathy management of multiple injured patients – a comprehensive literature review of the European guideline 2019." EFORT Open Reviews 7, no. 10 (2022): 710–26. http://dx.doi.org/10.1530/eor-22-0054.

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The European guideline on the management of trauma-induced major bleeding and coagulopathy summarises the most relevant recommendations for trauma coagulopathy management. The management of trauma-induced major bleeding should interdisciplinary follow algorithms which distinguish between life-threatening and non-life-threatening bleeding. Point-of-care viscoelastic methods (VEM) assist target-controlled haemostatic treatment. Neither conventional coagulation assays nor VEM should delay treatment in life-threatening trauma-induced bleeding. Adjustments may be rational due to local circumstances

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Santos, André Soares, Ananda Jessyla Felix Oliveira, Maria Carolina Lage Barbosa, and José Luiz dos Santos Nogueira. "Viscoelastic haemostatic assays in the perioperative period of surgical procedures: Systematic review and meta-analysis." Journal of Clinical Anesthesia 64 (September 2020): 109809. http://dx.doi.org/10.1016/j.jclinane.2020.109809.

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Dias, J. D., A. J. Butwick, J. Hartmann, and J. H. Waters. "Viscoelastic Haemostatic Point-of-Care Assays in the Management of Postpartum Haemorrhage: A Narrative Review." Obstetric Anesthesia Digest 43, no. 1 (2023): 16. http://dx.doi.org/10.1097/01.aoa.0000912260.60583.59.

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Zipperle, Johannes, Bernhard Ziegler, Herbert Schöchl, Wolfgang Voelckel, Christoph J. Schlimp, and Daniel Oberladstätter. "Operability of a Resonance-Based Viscoelastic Haemostatic Analyzer in the High-Vibration Environment of Air Medical Transport." Journal of Clinical Medicine 11, no. 13 (2022): 3630. http://dx.doi.org/10.3390/jcm11133630.

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Trauma and bleeding are associated with a high mortality, and most of these deaths occur early after injury. Viscoelastic haemostatic tests have gained increasing importance in goal-directed transfusion and bleeding management. A new generation of small-sized and thus portable ultrasound-based viscoelastic analysers have been introduced in clinical practice. We questioned whether a promising candidate can be used in emergency helicopters, with a focus on the susceptibility to vibration stress. We investigated whether the high vibration environment of an emergency helicopter would affect the op

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Kockelmann, Fabian, and Marc Maegele. "Acute Haemostatic Depletion and Failure in Patients with Traumatic Brain Injury (TBI): Pathophysiological and Clinical Considerations." Journal of Clinical Medicine 12, no. 8 (2023): 2809. http://dx.doi.org/10.3390/jcm12082809.

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Background: Because of the aging population, the number of low falls in elderly people with pre-existing anticoagulation is rising, often leading to traumatic brain injury (TBI) with a social and economic burden. Hemostatic disorders and disbalances seem to play a pivotal role in bleeding progression. Interrelationships between anticoagulatoric medication, coagulopathy, and bleeding progression seem to be a promising aim of therapy. Methods: We conducted a selective search of the literature in databases like Medline (Pubmed), Cochrane Library and current European treatment recommendations usin

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Nilsson, Caroline U., Karin Strandberg, and Peter Reinstrup. "Warfarin monitoring with viscoelastic haemostatic assays, thrombin generation, coagulation factors and correlations to Owren and Quick prothrombin time." Scandinavian Journal of Clinical and Laboratory Investigation 78, no. 5 (2018): 358–64. http://dx.doi.org/10.1080/00365513.2018.1474492.

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Ho, Vui Kian, Jolin Wong, Angelly Martinez, and James Winearls. "Trauma-induced coagulopathy: Mechanisms and clinical management." Annals of the Academy of Medicine, Singapore 51, no. 1 (2022): 40–48. http://dx.doi.org/10.47102/annals-acadmedsg.2020381.

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Introduction: Trauma-induced coagulopathy (TIC) is a form of coagulopathy unique to trauma patients and is associated with increased mortality. The complexity and incomplete understanding of TIC have resulted in controversies regarding optimum management. This review aims to summarise the pathophysiology of TIC and appraise established and emerging advances in the management of TIC. Methods: This narrative review is based on a literature search (MEDLINE database) completed in October 2020. Search terms used were “trauma induced coagulopathy”, “coagulopathy of trauma”, “trauma induced coagulopa

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Rigal, Jean-Christophe, Elodie Boissier, Karim Lakhal, Valéry-Pierre Riche, Isabelle Durand-Zaleski, and Bertrand Rozec. "Cost-effectiveness of point-of-care viscoelastic haemostatic assays in the management of bleeding during cardiac surgery: protocol for a prospective multicentre pragmatic study with stepped-wedge cluster randomised controlled design and 1-year follow-up (the IMOTEC study)." BMJ Open 9, no. 11 (2019): e029751. http://dx.doi.org/10.1136/bmjopen-2019-029751.

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IntroductionDuring cardiac surgery-associated bleeding, the early detection of coagulopathy is crucial. However, owing to time constraints or lack of suitable laboratory tests, transfusion of haemostatic products is often inappropriately triggered, either too late (exposing to prolonged bleeding and thus to avoidable administration of blood products) or blindly to the coagulation status (exposing to unnecessary haemostatic products administration in patients with no coagulopathy). Undue exposition to transfusion risks and additional healthcare costs may arise. With the perspective of secondary

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Babik, Barna, János Fazakas, Andrea Matusovits, and Béla Fülesdi. "Lépéskényszerben – új feladatok az életveszélyes perioperatív vérzések ellátásában." Orvosi Hetilap 160, no. 6 (2019): 203–13. http://dx.doi.org/10.1556/650.2019.31317.

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Abstract: Severe perioperative bleeding increases perioperative morbidity and mortality. The management of the consequences imposes high burden on the human and financial resources of healthcare providers. Since 2009, there has been a continued worldwide decline in demand for allogenic blood products. This tendency can mainly be attributed to Perioperative Blood Management Program and to new innovative management applying haemostatic factor concentrates, viscoelastic assays and guidelines for treatment of the severe periprocedural bleeding patients. One of the major challenges of our times is

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Baksaas-Aasen, Kjersti, Lewis Gall, Simon Eaglestone, et al. "iTACTIC – implementing Treatment Algorithms for the Correction of Trauma-Induced Coagulopathy: study protocol for a multicentre, randomised controlled trial." Trials 18, no. 1 (2017): 486. https://doi.org/10.1186/s13063-017-2224-9.

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<strong>Background: </strong>Traumatic injury is the fourth leading cause of death globally. Half of all trauma deaths are due to bleeding and most of these will occur within 6 h of injury. Haemorrhagic shock following injury has been shown to induce a clotting dysfunction within minutes, and this early trauma-induced coagulopathy (TIC) may exacerbate bleeding and is associated with higher mortality and morbidity. In spite of improved resuscitation strategies over the last decade, current transfusion therapy still fails to correct TIC during ongoing haemorrhage and evidence for the optimal man

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Soares Santos, André, Ananda Jessyla Felix Oliveira, Magda Lourenço Fernandes, José Luiz dos Santos Nogueira, Kenya Valéria Micaela de Souza Noronha, and Mônica Viegas Andrade. "Rotational thromboelastometry in the perioperative period of cardiac surgeries: cost-effectiveness analysis and budget impact." Jornal Brasileiro de Economia da Saúde 12, no. 3 (2020): 173–88. http://dx.doi.org/10.21115/jbes.v12.n3.p173-88.

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Objective: The transfusion of blood components and blood products in cardiac surgery patients can be guided by protocols based on standard laboratory tests and/or clinical decisions (Standardof-Care, SOC) or viscoelastic haemostatic assays (VHA). The aim of this study is to evaluate the cost-effectiveness and budget impact of VHAs compared to SOC. Methods: A decision tree model was built in TreeAge Pro® 2009. Costs and benefits were taken from the medical literature. The costeffectiveness was evaluated in a base-case scenario and a worst-case scenario, considering low costs of adverse events.

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George, Shane, Elizabeth Wake, Melanie Jansen, et al. "Fibrinogen Early In Severe paediatric Trauma studY (FEISTY junior): protocol for a randomised controlled trial." BMJ Open 12, no. 5 (2022): e057780. http://dx.doi.org/10.1136/bmjopen-2021-057780.

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IntroductionTrauma causes 40% of child deaths in high-income countries, with haemorrhage being a leading contributor to death in this population. There is a growing recognition that fibrinogen and platelets play a major role in trauma-induced coagulopathy (TIC) but the exact physiological mechanisms are poorly understood.Methods and analysisThis is a prospective multicentre, open-label, randomised, two-arm parallel feasibility study conducted in the emergency departments, intensive care units and operating theatres of participating hospitals. Severely injured children, aged between 3 months an

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Zipperle, Johannes, Wolfgang Holnthoner, Anna-Maria Husa, et al. "A novel coagulation assay incorporating adherent endothelial cells in thromboelastometry." Thrombosis and Haemostasis 109, no. 05 (2013): 869–77. http://dx.doi.org/10.1160/th12-10-0767.

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SummaryFollowing vascular injury or activation, endothelial cells (ECs) participate in the modulation of haemostasis and fibrinolysis. Viscoelastic tests (VETs) are a potent bedside monitoring tool that reports haemostatic parameters in real time. However, VETs neglect the influence of the surrounding endothelium. Our aim was therefore to establish an assay that incorporates ECs in a whole blood VET and to assess the impact of ECs on coagulation parameters. Outgrowth endothelial cells (OECs) and human umbilical vein endothelial cells (HUVECs) were seeded onto microbeads to create transferable

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Abraham, Paul, Pierre Pasquier, Thomas Rimmele, and Jean-Stephane David. "Trauma patients do not benefit from a viscoelastic haemostatic assay-guided protocol, but why?" Intensive Care Medicine 47, no. 6 (2021): 726–27. http://dx.doi.org/10.1007/s00134-021-06396-0.

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Baksaas-Aasen, K., L. S. Gall, J. Stensballe, et al. "Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial." Intensive Care Medicine 47, no. 1 (2020): 49–59. http://dx.doi.org/10.1007/s00134-020-06266-1.

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Gosselin, Robert, Dorothy Adcock, Shannon Bates, et al. "International Council for Standardization in Haematology (ICSH) Recommendations for Laboratory Measurement of Direct Oral Anticoagulants." Thrombosis and Haemostasis 118, no. 03 (2018): 437–50. http://dx.doi.org/10.1055/s-0038-1627480.

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AbstractThis guidance document was prepared on behalf of the International Council for Standardization in Haematology (ICSH) for providing haemostasis-related guidance documents for clinical laboratories. This inaugural coagulation ICSH document was developed by an ad hoc committee, comprised of international clinical and laboratory direct acting oral anticoagulant (DOAC) experts. The committee developed consensus recommendations for laboratory measurement of DOACs (dabigatran, rivaroxaban, apixaban and edoxaban), which would be germane for laboratories assessing DOAC anticoagulation. This gui

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Shah, Bhaumik Arvindkumar, Arulselvi Subramanium, Subhadra Sharma, Deepak Agrawal, Gaurav Chhabra, and Asok Kumar Mukhopadhyay. "Thromboelastography - Viscoelastic Haemostatic Assay (VHA) Versus Routine Plasma Based Coagulation Parameters in Trauma Patients to Detect Coagulopathy within 24 Hrs After Injury." Blood 118, no. 21 (2011): 5248. http://dx.doi.org/10.1182/blood.v118.21.5248.5248.

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Abstract Abstract 5248 In India trauma related deaths occur every 1.9 minutes. Mortality in severe traumatic injury (ISS>16) is six times higher in developing country like India. Coagulopathy is observed in almost 25– 30% of trauma patients which itself is an independent risk factor for haemorrhage. Coagulopathy detected early after injury is indicative of injury severity and itself is a prognostic factor for mortality. Aim To find out the usefulness of thromboelastography (TEG) in detecting coagulopathy in contrast to conventional methods of plasma based standard coagulation parameters (PT

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Gurunathan, Usha, Lisa M. Stanton, Rachael M. Weir, Karen E. Hay, and Bronwyn L. Pearse. "A preliminary study using rotational thromboelastometry to investigate perioperative coagulation changes and to identify hypercoagulability in obese patients undergoing total hip or knee replacement." Anaesthesia and Intensive Care 47, no. 5 (2019): 461–68. http://dx.doi.org/10.1177/0310057x19864114.

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Surgery and obesity are known risk factors for thromboembolic events due to the presence of a hypercoagulable state. Rotational thromboelastometry is a viscoelastic assay that can provide a measure of hypercoagulability via a comprehensive assessment of the coagulation process. This prospective study investigates haemostatic changes over time, presence of hypercoagulability and the association between body mass index and thromboelastometry results in patients undergoing major orthopaedic surgery. Fifty adult patients undergoing total hip or knee replacement surgery had serial thromboelastometr

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Wattanutchariya, Wassanai, Timothy Quek, and Suthipas Pongmanee. "The Biocompatibility and Occlusion Ability of a Zein-Based Biomaterial for Bone Surgery." Solid State Phenomena 266 (October 2017): 221–25. http://dx.doi.org/10.4028/www.scientific.net/ssp.266.221.

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During surgical procedures on bone, a common method of producing haemostasis at bleeding cancellous bone is the occlusion of blood vessels. This is often achieved with bone wax, which is not bioresorbable, unlike the zein-based biomaterial investigated in the present research. Zein is a prolamin derived from corn, and has been gaining importance as a bio-medical material. Taking advantage of its solubility in ethanol-water solvents but insolubility in water, a zein-based viscoelastic solid can be produced which effectively occludes the flow of fluids through a porous surface modelling cancello

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Dias, Joao D., Jerrold H. Levy, Kenichi A. Tanaka, Kai Zacharowski, and Jan Hartmann. "Viscoelastic haemostatic assays to guide therapy in elective surgery: an updated systematic review and meta‐analysis." Anaesthesia, November 14, 2024. http://dx.doi.org/10.1111/anae.16463.

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SummaryBackgroundPatients undergoing major surgery frequently experience major uncontrolled bleeding. The aim of this systematic review and meta‐analysis was to evaluate the clinical efficacy of using viscoelastic haemostatic assays to manage peri‐operative bleeding in elective surgery.MethodsWe searched PubMed/MEDLINE and Embase databases for randomised controlled trials according to pre‐determined criteria. The primary outcomes were blood product requirements; duration of stay in the operating theatre or ICU; and surgical reintervention rate.ResultsWe included 20 randomised controlled trials

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Rali, Aniket S., Ahmed M. Salem, Melat Gebre, Taylor M. Garies, Siva Taduru, and Arthur W. Bracey. "Viscoelastic Haemostatic Assays in Cardiovascular Critical Care." Cardiac Failure Review 7 (February 19, 2021). http://dx.doi.org/10.15420/cfr.2020.22.

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The initiation and management of anticoagulation is a fundamental practice for a wide variety of indications in cardiovascular critical care, including the management of patients with acute MI, stroke prevention in patients with AF or mechanical valves, as well as the prevention of device thrombosis and thromboembolic events with the use of mechanical circulatory support and ventricular assist devices. The frequent use of antiplatelet and anticoagulation therapy, in addition to the presence of concomitant conditions that may lead to a propensity to bleed, such as renal and liver dysfunction, p

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Mitra, Biswadev, Margaret Jorgensen, Michael C. Reade, et al. "Patient blood management guideline for adults with critical bleeding." Medical Journal of Australia, January 28, 2024. http://dx.doi.org/10.5694/mja2.52212.

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AbstractIntroductionThe management of patients with critical bleeding requires a multidisciplinary approach to achieve haemostasis, optimise physiology, and guide blood component use. The 2011 Patient blood management guidelines: module 1 — critical bleeding/massive transfusion were updated and published. Systematic reviews were conducted for pre‐specified research questions, and recommendations were based on meta‐analyses of included studies.Main recommendationsThe critical bleeding/massive transfusion guideline includes seven recommendations and 11 good practice statements addressing: major

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Smith, Jennifer. "How should we measure platelet count before central neuraxial blockade in parturients with thrombocytopenia?" British Journal of Hospital Medicine, January 5, 2023, 1–2. http://dx.doi.org/10.12968/hmed.2022.0224.

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Patients with low platelet counts are a concern to the obstetric anaesthetist as, although rare, there is a risk of a spinal epidural haematoma following central neuraxial blockade. Although conventional plasma-based tests are frequently used to guide central neuraxial blockade in patients with thrombocytopenia, interest in the use of viscoelastic haemostatic assays is increasing.

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Maynard, Suzanne, Elizabeth Marrinan, Lara Roberts, and Simon Stanworth. "Does the use of viscoelastic haemostatic assays for risk periprocedural haemostasis management in liver disease improve clinical outcomes?" Transfusion Medicine Reviews, March 2024, 150823. http://dx.doi.org/10.1016/j.tmrv.2024.150823.

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Bell, Sarah F., Lucy de Lloyd, Nicholas Preston, and Peter W. Collins. "Managing the coagulopathy of postpartum haemorrhage: an evolving role for viscoelastic haemostatic assays." Journal of Thrombosis and Haemostasis, April 2023. http://dx.doi.org/10.1016/j.jtha.2023.03.029.

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Dias, J. D., A. J. Butwick, J. Hartmann, and J. H. Waters. "Viscoelastic haemostatic point‐of‐care assays in the management of postpartum haemorrhage: a narrative review." Anaesthesia, February 22, 2022. http://dx.doi.org/10.1111/anae.15662.

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Coggins, Andrew Richard, Vinh Dat David Nguyen, Leonardo Pasalic, Murari Ramesh, and Kush Wangoo. "Utility of point of care viscoelastic haemostatic assays for trauma patients in the emergency department." Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 33, no. 1 (2025). https://doi.org/10.1186/s13049-025-01388-1.

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Abstract Background and objectives Traumatic haemorrhage often requires initiation of a massive haemorrhage protocol (MHP). The primary aim of this exploratory Emergency Department (ED) study was to examine the utility of point of care Viscoelastic Haemostatic Assays (VHA) in terms of accuracy. The primary outcome was prediction of the need for massive transfusion (MT) at 24-hours. Methods Prospective observational study of consecutive trauma patients investigated with reported using STARD guidelines. Patients in an Australian ED setting < 1-hour from triage enrolled in a three-year window.

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Forster, Ellen K., Simon Hendel, and Biswadev Mitra. "Detection of Acute Traumatic Coagulopathy by Viscoelastic Haemostatic Assays Compared to Standard Laboratory Tests: A Systematic Review." Transfusion Medicine and Hemotherapy, December 12, 2022, 1–13. http://dx.doi.org/10.1159/000526217.

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<b><i>Introduction:</i></b> The aim of this systematic review was to investigate whether viscoelastic haemostatic assays (VHAs) offer comparative diagnostic ability of acute traumatic coagulopathy (ATC) compared to the standard laboratory coagulation tests (SLCT). ATC is a complication of major trauma characterized by dysfunctional blood clotting, leading to an increased bleeding risk. Additionally, we aimed to analyse the association of VHA with blood product use and health outcomes. <b><i>Methods:</i></b> The search protocol was pre-published a

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Latona, Akmez, James Winearls, Kate Hill, Michelle Spanevello, and Biswadev Mitra. "Variability in viscoelastic haemostatic assay in major haemorrhage protocols: A unified approach or mixed signals?" Transfusion Medicine, July 23, 2025. https://doi.org/10.1111/tme.70003.

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AbstractBackground and ObjectivesViscoelastic haemostatic assays (VHA) are part of patient blood management (PBM) for bleeding, associated with reduced transfusions. This study reviewed all major haemorrhage protocols (MHPs) using VHA in Queensland, Australia, and assessed variability.MethodsVHA platforms in Queensland Health include rotational thromboelastometry (ROTEM® Sigma) and thromboelastography (TEG 6 s). PBM guidelines were searched for VHA‐guided MHPs. Outcomes included viscoelastic thresholds and transfusion recommendations.ResultsNineteen hospitals used VHA: sixteen with ROTEM and t

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Mitra, Biswadev, Elizabeth Wake, Carly Talarico, et al. "Resuscitation of adult shocked trauma patients using major haemorrhage protocol guided by viscoelastic haemostatic assays versus formulaic approach." Transfusion Medicine, November 8, 2024. http://dx.doi.org/10.1111/tme.13109.

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AbstractBackgroundThe resuscitation of trauma patients with critical bleeding may follow a formulaic approach using high ratios of blood components or a viscoelastic haemostatic assay (VHA) guided approach. The aim of this study was to compare the two strategies for resuscitation of shocked trauma patients.MethodsThis was a registry‐based cohort study including shocked trauma patients from two trauma centres–one practising a formulaic approach, with VHA unavailable during trauma resuscitation and the other practicing a VHA‐guided resuscitation strategy. The primary outcome was the total units

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Ilvonen, Petra, Sanna Susila, Ulla Impola, et al. "Extracellular vesicles in ageing cold‐stored whole blood may not compensate for the decreasing haemostatic function in vitro." Transfusion Medicine, January 24, 2025. https://doi.org/10.1111/tme.13122.

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AbstractBackgroundExtracellular vesicles (EVs) have procoagulative properties. As EVs are known to accumulate in stored blood products, we compared the EV content and coagulation capacity of leukoreduced cold‐stored whole blood (CSWB) with current prehospital and in‐hospital component therapies to understand the role of EVs in the haemostatic capacity of ageing CSWB.Materials and MethodsBlood was obtained from 12 O RhD‐positive male donors. CSWB was compared with in‐hospital component therapy of red blood cells (RBCs), OctaplasLG and buffy‐coat platelets and prehospital component therapy of RB

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Fahrendorff, Mathilde, Roberto S. Oliveri, and Pär I. Johansson. "The use of viscoelastic haemostatic assays in goal-directing treatment with allogeneic blood products – A systematic review and meta-analysis." Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 25, no. 1 (2017). http://dx.doi.org/10.1186/s13049-017-0378-9.

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Jonish, Anten P., Joses Dany James, D. K. Titus, et al. "Conventional Coagulation Tests are a better predictor of mortality than Viscoelastic Haemostatic Assays in trauma patients with shock: a prospective observational study." European Journal of Trauma and Emergency Surgery 51, no. 1 (2025). https://doi.org/10.1007/s00068-025-02808-8.

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David, Jean-Stéphane, Arthur James, Maxime Orion, et al. "Thromboelastometry-guided haemostatic resuscitation in severely injured patients: a propensity score-matched study." Critical Care 27, no. 1 (2023). http://dx.doi.org/10.1186/s13054-023-04421-w.

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Abstract Background To accelerate the diagnosis and treatment of trauma-induced coagulopathy (TIC), viscoelastic haemostatic assays (VHA) are increasingly used worldwide, although their value is still debated, with a recent randomised trial showing no improvement in outcome. The objective of this retrospective study was to compare 2 cohorts of injured patients in which TIC was managed with either a VHA-based algorithm or a conventional coagulation test (CCT)-based algorithm. Methods Data were retrieved from 2 registries and patients were included in the study if they received at least 1 unit o

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Yeung, Maximus CF, Steven YT Tong, Paul YW Tong, Billy HH Cheung, Joanne YW Ng, and Gilberto KK Leung. "Use of viscoelastic haemostatic assay in emergency and elective surgery." Hong Kong Medical Journal, August 1, 2014. http://dx.doi.org/10.12809/hkmj134147.

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Baksaas-Aasen, Kjersti, Lewis Simpson Gall, Jakob Stensballe, et al. "Viscoelastic Haemostatic Assay Augmented Protocols for Major Trauma Haemorrhage (ITACTIC): A Randomised, Controlled Trial." SSRN Electronic Journal, 2020. http://dx.doi.org/10.2139/ssrn.3523858.

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Kataria, Sahil, Deven Juneja, and Omender Singh. "Redefining haemostasis: Role of rotational thromboelastometry in critical care settings." World Journal of Critical Care Medicine 14, no. 2 (2025). https://doi.org/10.5492/wjccm.v14.i2.102521.

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Management of patients with acute hemorrhage requires addressing the source of bleeding, replenishing blood volume, and addressing any coagulopathy that may be present. Assessing coagulopathy and predicting blood requirements in real-time in patients experiencing ongoing bleeding can pose substantial challenges. In these patients, transfusion concepts based on ratios do not effectively address coagulopathy or reduce mortality. Moreover, ratio-based concepts do not stop bleeding; instead, they just give physicians more time to identify the bleeding source and plan management strategies. In clin

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Hofmeyr, G. J. "Novel concepts and improvisation for treating postpartum haemorrhage: a narrative review of emerging techniques." Reproductive Health 20, no. 1 (2023). http://dx.doi.org/10.1186/s12978-023-01657-1.

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Abstract Background Most treatments for postpartum haemorrhage (PPH) lack evidence of effectiveness. New innovations are ubiquitous but have not been synthesized for ready access. Narrative review Pubmed 2020 to 2021 was searched on ‘postpartum haemorrhage treatment’, and novel reports among 755 citations were catalogued. New health care strategies included early diagnosis with a bundled first response and home-based treatment of PPH. A calibrated postpartum blood monitoring tray has been described. Oxytocin is more effective than misoprostol; addition of misoprostol to oxytocin does not impro

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