To see the other types of publications on this topic, follow the link: Visual brainstorms.
Journal articles on the topic 'Visual brainstorms'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 16 journal articles for your research on the topic 'Visual brainstorms.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Chholak, Parth, Semen A. Kurkin, Alexander E. Hramov, and Alexander N. Pisarchik. "Event-Related Coherence in Visual Cortex and Brain Noise: An MEG Study." Applied Sciences 11, no. 1 (January 2, 2021): 375. http://dx.doi.org/10.3390/app11010375.
Full textAbstract:
The analysis of neurophysiological data using the two most widely used open-source MATLAB toolboxes, FieldTrip and Brainstorm, validates our hypothesis about the correlation between event-related coherence in the visual cortex and neuronal noise. The analyzed data were obtained from magnetoencephalography (MEG) experiments based on visual perception of flickering stimuli, in which fifteen subjects effectively participated. Before coherence and brain noise calculations, MEG data were first transformed from recorded channel data to brain source waveforms by solving the inverse problem. The inverse solution was obtained for a 2D cortical shape in Brainstorm and a 3D volume in FieldTrip. We found that stronger brain entrainment to the visual stimuli concurred with higher brain noise in both studies.
2
Ritter, Simone M., and Nel M. Mostert. "How to facilitate a brainstorming session: The effect of idea generation techniques and of group brainstorm after individual brainstorm." Creative Industries Journal 11, no. 3 (September 2, 2018): 263–77. http://dx.doi.org/10.1080/17510694.2018.1523662.
Full text
3
Werbel, Amy. "Imagining the Future of Monuments to the Confederacy: Students Brainstorm Interpretive Strategies." Sculpture Review 66, no. 4 (December 2017): 32–37. http://dx.doi.org/10.1177/074752841706600405.
Full text
4
TAKAMA, YASUFUMI, and GAKU KOINUMA. "VISUAL ANALYSIS OF DISCUSSION FLOW ON KEYGRAPH-BASED BBS." New Mathematics and Natural Computation 06, no. 02 (July 2010): 229–45. http://dx.doi.org/10.1142/s1793005710001682.
Full textAbstract:
A method for visualizing discussion flow is proposed for analyzing the thread in KGBBS (KeyGraph-based BBS). It is known that group discussion is effective for chance discovery, in which information visualization plays an important role in providing participants with a material to that brainstorm various ideas, opinions, and interpretations. In order to enable online discussion while sharing the same visualized material, KGBBS is proposed based on KeyGraph, which is one of the typical visualization techniques in chance discovery. The aim of this paper is to utilize the result of discussion using KGBBS, by visualizing discussion flow of the thread in KGBBS. The method consists of 2 kinds of visualization techniques — a comment chain diagram to visualize the structure of comment chain, and a visual summary on KeyGraph to visualize concrete transition of topics through successive 2 or 3 comments. The proposed method is applied to actual discussion data, and the analysis results show the combination of both the visualization techniques, making it possible to analyze concrete transition of topics without reading comments in a thread.
5
Rosário, Sâmara Sirdênia Duarte de, Francisco Arnoldo Nunes de Miranda, Isabelle Katherinne Fernandes Costa, Alexsandro Silva Coura, Inácia Sátiro Xavier de França, and Glauber Weder dos Santos Silva. "Instrumento avaliativo de necessidades em saúde de pessoas com deficiência: estudo metodológico." Online Brazilian Journal of Nursing 16, no. 3 (August 24, 2018): 331. http://dx.doi.org/10.17665/1676-4285.20175722.
Full textAbstract:
Aim: To describe the semantic validation process of an instrument for assessing health needs for people with physical, hearing and visual impairment (IANS-PcDFAV). Method: This is a methodological study carried out between April and May 2016, regarding the semantic and appearance validation stage. Eight disabled persons, registered in three support institutions, responded to three instruments: general and specific impression questionnaire and the IANS-PcDFAV. Brainstorm technique was used. It was analyzed by descriptive statistics and by the frequency of the presented answers. Results: The instrument was considered important or very important, with items that are easy to understand. Of the 32 original items, eight were changed for the better understanding and four were negativated, one in each dimension. Conclusion: The instrument was comprehensible for all strata of the studied population, confirming it as valid in terms of semantics and appearance.
6
Zakwoi, Iliya S., Soyinka O. Kolawole, Ogbeide O. K, and Omeiza I. O. A. "Radial Line Slot Array Antenna Feeder Design Using Optimization Algorithm." Modern Applied Science 13, no. 1 (December 31, 2018): 214. http://dx.doi.org/10.5539/mas.v13n1p214.
Full textAbstract:
High Bandwidth is required today to meet the demands for high data rates needed for future Direct-to Home (DTH) services in Ka-Band. In this work, the Brainstorm Optimization (BSO) method for the feeder architecture design is utilized to meet this need at 28GHz. The BSO is used as tool for the optimization of the beam squinted antenna feeder parameters in terms of air gaps, radial cavity dimensions and dielectric thickness needed for the optimal customization of the conventional Sub-Miniature A (SMA) connector for enhanced bandwidth realization in Ka Band at 28 GHz required for Direct to Home Services (DTH). Solutions values realized from the BSO algorithm using MATLAB computations were included in a visual BASIC program in the macros of CST 2017 microwave suites for pattern generation and antenna radiation characteristics computations A radiation efficiency value of 95.97% was achieved, an Impedance Bandwidth of 99.61% and Gain of 23.09dBi were achieved. Results were compared with earlier studies on Ka Band at 28GHz and the results shows an improvement in the bandwidth and directivity values.
7
Mahendrapati, Alexander Nawangseto. "VISUALISASI DOA JALAN SALIB MENGADOPSI GAYA WAYANG BEBER DENGAN TEKNIK SENI GRAFIS CUKIL KAYU." Brikolase : Jurnal Kajian Teori, Praktik dan Wacana Seni Budaya Rupa 11, no. 2 (February 21, 2020): 154–66. http://dx.doi.org/10.33153/brikolase.v11i2.2931.
Full textAbstract:
Research covered titled visualize prayer road crosses by adopting the Wayang Beber style used a woodcut technique of the printmaking is the artistic research (the creation of art) that is carried out based on the art of printing graphic especially a woodcut which is initially be used as a tool to increase religious manuscripts , book illustrations , and then used as propaganda media can be printed because she is the presence of many unique visual and character .Pengkarya use uniqueness in the graphic arts this as an element that reinforce the value estetik and artistic work in visual. This research which was conducted with us is to conduct a study on the degree to which the prayers of devotion road crosses was influential on the strengthening of the value of the true faith admit this catholics in general. The study on Wayang Beber show some years previously had broken also needs to be undertaken of the aspect of visual and if they used these tools as a means of second to disseminate the rudimentary and elemental teachings religious and the good aspects it has done. Through a process go brainstorm and the review of visual artworks in with the theme of or illustration the story of poor reduced to such misery in its course the cross of Jesus Christ was one of those which is borne by their stations of a place of rest the way of a cross in religious place then enacted into a the theme of the creation of the aertwork. The hope is by the creation of the work of the printmaking is due to the activities to give alternarif new in the perspective of all the participants to pray visualization road crosses as well as as a medium for the congregation of the Catholics to are more likely to set on other concerns the road crosses and make him of the love of the faithful for accordance with what god has cope with life.
8
Pruettikomon, Soraj, and Chaturong Louhapensang. "A Study and Development of Workplace Facilities and Working Environment to Increase the Work Efficiency of Persons with Disabilities: A Case Study of Major Retail and Wholesale Companies in Bangkok." Scientific World Journal 2018 (August 19, 2018): 1–12. http://dx.doi.org/10.1155/2018/3142010.
Full textAbstract:
This research aims to improve the work effectiveness of people with physical disabilities in department stores, retail and wholesale companies in Bangkok. It focuses on the environment and facilities needed by people with three types of disabilities, visual impairment, hearing impairment, and wheelchair users. A mixed research method was used (questionnaires, interviews, and observations). The results were applied to a design process based on the needs of people with physical disabilities and addressed solving their work problems, increasing their work effectiveness, and bringing the results of the design to a group discussion. The group was made up of 15 experts who were supervisors, representatives of the people with each type of physical disability, instructors, and personnel from the university knowledgeable about universal design for people with disabilities. Architects and designers helped to brainstorm ideas and develop designs that led to production and product testing. Testing was conducted to compare pretest and posttest results using designed products to evaluate the work effectiveness of the people with physical disabilities using statistical analysis (paired t-tests). The results using developed products showed a higher average posttest score than pretest. This indicated a statistically higher work effectiveness (α =0.05) and supports the research hypothesis.
9
Howell, Britteny M., and Daniel McLinden. "BARRIERS AND OPPORTUNITIES TO HEALTHY AGING IN ANCHORAGE, ALASKA, USING CONCEPT MAPPING." Innovation in Aging 3, Supplement_1 (November 2019): S422—S423. http://dx.doi.org/10.1093/geroni/igz038.1578.
Full textAbstract:
Abstract Alaska currently has the fastest growing proportion of older adults than any state in the country, and seniors are choosing to age-in-place in Anchorage in record numbers. Research shows that including older adults with community-based professionals (aging advocates, researchers, service providers) in focus group activities can provide a rich and holistic model of aging that demonstrates a robust foundation for supporting aging and addressing health disparities. This paper presents the results of a project conducted with older adults (50+ years), advocates, and other stakeholders in Anchorage using Concept Mapping (CM) methodology, a technique not often used in the gerontology literature. CM is a mixed-method, participatory approach that uses brainstorming and unstructured card-sorting combined with multivariate statistics (multi-dimensional scaling, hierarchical cluster analysis) to create a data-driven visual representation of thoughts or ideas of a community. CM is well suited to integrating perspectives from multiple points of view. Participants were prompted to address the research question: how do we think about aging in Anchorage & what are the barriers and facilitators to aging well? Results indicate services for seniors should include culturally responsive health programming, low-cost opportunities for social engagement, inclusion of older adults with intellectual/developmental disabilities, transportation considerations, navigators to locate services in Anchorage, and more. CM allowed the researchers to identify how residents view healthy aging in this urban subarctic location and brainstorm practical solutions with stakeholders and local policy-makers. This presentation will also share lessons-learned regarding the use of this participatory approach with older adults.
10
Бучацька, Світлана. "Psychological Foundations of Mind Mapping Strategies." East European Journal of Psycholinguistics 3, no. 1 (June 30, 2016): 34–44. http://dx.doi.org/10.29038/eejpl.2016.3.1.buc.
Full textAbstract:
The present study investigates psychological foundations of mind mapping as one of the relevant tools in teaching and learning process. A Mind Map, the modern approach implemented and developed by Tony Buzan is viewed as a visual diagram used to record and organise information in a way which the brain finds captivating and easy to process. It is based on the conception of radial tree, diagramming key words in a colorful, radiant, tree-like structure. The study focuses on the theoretical analysis of brain’s as well as cerebral hemispheres’ functioning aiming to explain the claimed increased effectiveness of mind mapping over other forms of learning, understanding, remembering and performing. Much attention is devoted to the benefits and challenges of using mind maps. Thus, some sufficient mind mapping strategies for English teachers which can be effectively used in the classroom have been presented. The research confirms that mind mapping is a beneficial learning tool to help students brainstorm any topic and think creatively. It is a powerful way for students to reach high levels of cognitive performance.
References
Abi-El-Mona, I., & Ad-El-Khalick, F (2008). The Influence of Mind Mapping on Eighth Graders' Science Achievement. School Science and Mathematics, 108, 298-312.
Buchatska, S. (2015). Anxiety factors of students’ emotional disposition to professional communication in foreign languages. East European Journal of Psycholinguistics. 2(1), 3–10.
Buzan, T. and Buzan, B. (1993). The mind map book: How to use radiant thinking to maximize your brains untapped potential. Dutton.
Buzan, T., & Buzan, B. (2010). The Mind Map Book. Unlock your creativity, boost your memory, change your life. Harlow, England: Pearson.
Cunningham, W. A., Raye, C. L., & Johnson, M. K. (2005). Neural correlates of evaluation associated with promotion and prevention regulatory focus. Cognitive, Affective, & Behavioral Neuroscience, 5, 202-211.
Farrand, P., Hussain, F., & Hennessey, E. (2002). The efficacy of the ‘mind map' study technique. Medical Education, 36, 426-431.
Gardner, H. (1993). Multiple Intelligences. New York: Basic Books.
Novak, J. D., & Cañas, A.J. (2008). The Theory Underlying Concept Maps and How to Construct and Use Them. Institute for Human and Machine Cognition. Pensacola Fl. Retrieved from http://www.ihmc.us.
Paivio, A. (1971). Imagery and Verbal Processes. New York: Holt, Rinehart and Winston. (Republished in 1979 – Hillsdale, NJ: Erlbaum.)
Yates, F.A. (1966). The Art of Memory. London: Routledge and Kegan Paul.
11
Roberson, Janie, Allison Wrenn, John Poole, Andrew Jaeger, and Isam A. Eltoum. "Constructing a modern cytology laboratory: A toolkit for planning and design." CytoJournal 10 (February 28, 2013): 3. http://dx.doi.org/10.4103/1742-6413.107983.
Full textAbstract:
Introduction: Constructing or renovating a laboratory can be both challenging and rewarding. UAB Cytology (UAB CY) recently undertook a project to relocate from a building constructed in 1928 to new space. UAB CY is part of an academic center that provides service to a large set of patients, support training of one cytotechnology program and one cytopathology fellowship training program and involve actively in research and scholarly activity. Our objectives were to provide a safe, aesthetically pleasing space and gain efficiencies through lean processes. Methods: The phases of any laboratory design project are Planning, Schematic Design (SD), Design Development (DD), Construction Documents (CD) and Construction. Lab personnel are most critical in the Planning phase. During this time stakeholders, relationships, budget, square footage and equipment were identified. Equipment lists, including what would be relocated, purchased new and projected for future growth ensure that utilities were matched to expected need. A chemical inventory was prepared and adequate storage space was planned. Regulatory and safety requirements were discussed. Tours and high level process flow diagrams helped architects and engineers understand the laboratory daily work. Future needs were addressed through a questionnaire which identified potential areas of growth and technological change. Throughout the project, decisions were driven by data from the planning phase. During the SD phase, objective information from the first phase was used by architects and planners to create a general floor plan. This was the basis of a series of meetings to brainstorm and suggest modifications. DD brings more detail to the plans with engineering, casework, equipment specifics, finishes. Design changes should be completed at this phase. The next phase, CD took the project from the lab purview into purely technical mode. Construction documents were used by the contractor for the bidding process and ultimately the Construction phase. Results: The project fitted out a total of 9,000 square feet; 4,000 laboratory and 5,000 office/support. Lab space includes areas for Prep, CT screening, sign out and Imaging. Adjacent space houses faculty offices and conferencing facilities. Transportation time was reduced (waste removal) by a Pneumatic Tube System, specimen drop window to Prep Lab and a pass thru window to the screening area. Open screening and prep areas allow visual management control. Efficiencies were gained by ergonomically placing CT Manual and Imaging microscopes and computers in close proximity, also facilitating a paperless workflow for additional savings. Logistically, closer proximity to Surgical Pathology maximized the natural synergies between the areas. Conclusions: Lab construction should be a systematic process based on sound principles for safety, high quality testing, and finance. Our detailed planning and design process can be a model for others undertaking similar projects
12
Zhang, Melvyn, Sandor Heng, Guo Song, Daniel SS Fung, and Helen E. Smith. "Co-designing a Mobile Gamified Attention Bias Modification Intervention for Substance Use Disorders: Participatory Research Study." JMIR mHealth and uHealth 7, no. 10 (October 3, 2019): e15871. http://dx.doi.org/10.2196/15871.
Full textAbstract:
Background Advances in experimental psychology have highlighted the need to modify underlying automatic cognitive biases, such as attentional biases. The effectiveness of bias modification has been well studied for substance use disorders. With recent advances in technology, it is now possible to work outside the laboratory with Web-based and mobile-based attention bias interventions. Gamification technologies might also help diminish the repetitiveness of the task and increase the intrinsic motivation to train. The inconsistent findings of the impact of gaming on the effectiveness of mobile interventions call for further work to better understand the needs of patients (users) and health care professionals. Objective The aim of this study was to involve patients, together with health care professionals, in the design of a gamified mobile attention bias modification intervention for substance use disorders. Methods The participatory design research method adopted is that of a user-oriented design approach in the form of a future workshop. In the first phase of the workshop, participants shared their critique of an attention bias modification intervention. In the second phase of the workshop, participants were asked to brainstorm features. Participants were also shown gamification approaches and asked to consider if gaming elements could enhance the existing app. In the last phase, participants were asked to sketch a new prototype. Results Three co-design workshops were conducted with health care professionals, inpatients, and outpatients. There were 20 participants, consisting of 10 health care professionals and 10 patients. When asked to identify the limitations in the existing app, common issues identified were those of the design, visual probe task, and the included images. Outpatients were also concerned with the safety of administration of the intervention. In the brainstorming sessions, health care professionals made recommendations as to how the stimulus, the mechanism of responding, and the presentation of the scores could be enhanced. Inpatient participants recommended the addition of functionalities, such as information on the harms associated with the substance use, and for there to be enhancements in the design, images, and task. Outpatient participants perceived a need to improve the images and presentation of the results and recommended the inclusion of gaming features. There were differences in opinion on the inclusion of gaming features, as only health care professionals endorsed their inclusion. In the last phase of the workshop, participants were tasked with the conceptualization of prototypes, and the commonality in the design was for a gradual shortening of the interval for stimulus/image presentation. Conclusions The results from this research will guide the development of an app that meets the specific needs of patients and is still based on a pre-existing validated task paradigm.
13
Tılfarlıoğlu, Filiz Yalçın, and Jivan Kamal Anwer. "Integration of Lean method in English Language Teaching and Learning: A New Perspective." Journal of Education and Training Studies 5, no. 9 (August 27, 2017): 230. http://dx.doi.org/10.11114/jets.v5i9.2625.
Full textAbstract:
Lean is regarded as a systematic approach to maximizing value by minimizing waste, and by flowing the product or service at the pull of the customer demand. These key concepts of “value,” “flow,” and “pull,” align with the ultimate lean goal: “perfection,” or a continuous striving for improvement in the performance of the organization. Through applying a lean methodology to the teaching processes, additionally the teachers can eliminate reasons that do not add value and are thus wasteful, and they can focus their efforts on the advancement of teaching and learning. By applying the lean principles and techniques developed in the industry, educators can refine the content, pedagogy, organization, and assessment methods employed in their accounting courses to help and ensure that students gain the knowledge and skills that will make them most desirable to students. Lean can be taught throughout several methods and tools, such as readings and class discussion, game- and simulation-based methods, and the open forum method. The readings and discussion method present students with the opportunity, and even the obligation, to express their Point of view on certain issues, requiring the students to think critically on the subject and use logic to evaluate others' positions through open and active participation. When applying lean production to learning, we should first identify the process and then maintain focus on what adds value (i.e., student improvements), empower students to do CI (continuous improvement), eliminate what does not add value through Kaizen (brainstorm alternatives and identify a hypothesis to test), conduct PDCA (develop an experimental plan, carry out the plan or do it and then check for results and adjust accordingly), and make a team work to support and share with each other. To apply lean thinking and to create a lean culture classroom, the classroom should first be organized; thereafter, visual sheets should be managed, pre-planning must be done, take-time should be established, and work should be standardized by creating syllabi and schedules and associated materials. Other classroom tools must be available as well, such as Pareto charts, root cause, and weekly quality assessments. To fulfill this objective, a research question has been approved as a data collection instrument in this descriptive study, a 35 item questionnaire was administered to English preparatory school student at Duhok city and an interview was conducted with twelves students with different levels in Sabis International School. In addition, the descriptive statistics indicated that the male learners employed language learning strategies more frequently (average=3.3) than the female learners (average=3.2) One can conclude that male students use lean learning strategies more than female student do. The value of (F) is 2.479, which reflects the dependency to be at significant levels (>0.01 at the level of 1%). Rendering to this model, duration of taking English (b = 1.534, p= .116 p > .01) is statistically not significant predictor of learning lean method. Value of T which is (27.87> .01) and the Value of P (.000) reveals the descriptive factor of gender effect on learning lean method as statistically significant. Besides, all the values in the regression model come out to support the view that gender is effective in the use of learning the lean method. The result also indicates that the duration of taking English does not significantly effect on learning and using lean learning strategies as it reveals in ANOVA analysis. In conclude, the result showed that when student get older and takes more English course, the more learning lean methods they apply in learning language.
14
Duropan, Aida. "Use of Visual Arts in Facilitating the Speaking Skills of Students." Asian Journal of Education and Social Studies, March 6, 2020, 1–10. http://dx.doi.org/10.9734/ajess/2020/v7i130185.
Full textAbstract:
Aims: This study examined visual arts activities as means of enhancing speaking abilities of students. It also explored how the participants find the use of visual arts activities as strategy; how visual arts activities in English class were conducted; and what suggestions the participants can offer to improve the conduct of visual arts activities.
Study Design: This study used the qualitative method particularly the phenomenological approach.
Place and Duration of Study: The study was conducted in Davao del Sur State College, Digos City. It was conducted during the first semester of 2019-2020.
Methodology: The 20 participants were purposively chosen. They were grouped into four focus groups. Interview guide-questionnaire based on the research questions was the main instrument used in obtaining the information.
Results: The use of visual arts in English language class was interesting and effective. The student-participants found the strategy interesting because they were able to express their ideas by looking at the images. They were able to formulate sentences instantly. Importantly, giving clear instructions on what to do and allocating appropriate time to gather their thoughts; learners were able to formulate ideas and confidently share their answers to the class. The learners suggested that speaking activities through visual arts strategy may be improved if language teachers use colorful arts; consideration of time to think; regular conduct of the strategy; allow brainstorm with other students before they are asked to speak; and everyone should be allotted time to speak. The suggestions imply that the students favor and willing the use of visual art in their speaking activities.
Conclusion: The appreciation of students on the use visual arts in enhancing their speaking abilities is a clear manifestation that visual arts is an effective tool in encouraging students to speak. The reason why students appreciated visual art is the motivation it provides. The visual effect of art to the students ignites and challenges them to formulate words. Thus, the use of visual art activities transform the students from uninterested to interested, from passive to active, from blunt to critical thinker. On the other hand, clear instructions to the students allow them to carry out the task according to the expected output. Moreover, time is a key element for learners to formulate well-thought answers. Hence, teachers may give provisions for time. Likewise, students clamor that visual arts should be colorful so that they could appreciate the art. However, they may not be relevant because the visual meaning does not depend on color. Interestingly, the results of study lead the English teachers to think of possible actions so that the conduct of speaking classes using visual arts may be improved. Authentic visuals arts which depict historical significance may be utilized. It may not only let the learners appreciate history but also develop cultural attitudes. Teachers may also provide and explain a speaking rubrics before the students do the task. This makes the learners informed and allows them to strategize. Lastly, teachers may also consider thematizing the visual arts so that learners become more interested and engaged.
15
Gruters, Angélique A., Inez H. G. B. Ramakers, Annemarie P. M. Stiekema, Frans R. J. Verhey, Roy P. C. Kessels, and Marjolein E. de Vugt. "An Exploratory Study of the Development and Pilot Testing of an Interactive Visual Tool of Neuropsychological Test Results in Memory Clinics." Journal of Alzheimer's Disease, December 29, 2020, 1–14. http://dx.doi.org/10.3233/jad-201128.
Full textAbstract:
Background: Neuropsychological feedback is an important part of the neuropsychological assessment process. However, patients have difficulties remembering this information. Objective: The aim of this study was to develop a web-based visual tool to improve the understanding of neuropsychological results, information retention, and psychologist-patient communication. Methods: The visual tool was developed and optimized using an iterative three-phase stepwise approach to determine its usability, technology acceptance, and feasibility in a memory clinic population. Feedback from different user perspectives (patients, family members, and psychologists) was obtained in each phase using a multimethod approach (e.g., a multidisciplinary brainstorm session, think-aloud sessions, focus groups). The prototype was subsequently tested in a pilot study. Results: The first phases offered insights that led to optimization of the prototype. On a scale ranging from 0 to 100, psychologists evaluated the usability as high [88.1±7.6,70–87]. During the pilot study, both patients and significant others gave positive feedback, but information retention in patients remained low. All participants thought the benefits of the visual tool included seeing cognitive strengths and weaknesses with a translation to daily life all at one glance and receiving feedback on paper to take home. Important barriers were mentioned by psychologists, such as a limited set of tests included and no integration with hospital systems. Conclusion: Overall, patients, family members, and psychologists reported that a visual display of the cognitive profile with insights into daily life had added value to clinical practice. Feedback from the pilot study was adopted in the tool for future implementation purposes.
16
Bykerk, Vivian, Wenhui Wei, Susan Boklage, Toshio Kimura, Stefano Fiore, and Gregory St John. "EP25 Impact of sarilumab on unacceptable pain and inflammation control in moderately-to-severely active rheumatoid arthritis (RA) patients in 3 Phase 3 studies." Rheumatology 59, Supplement_2 (April 1, 2020). http://dx.doi.org/10.1093/rheumatology/keaa109.024.
Full textAbstract:
Abstract Background In RA patients, unacceptable pain (UP) may persist despite inflammation control (refractory pain [RP]). Sarilumab is indicated (either with methotrexate or as monotherapy if methotrexate is not tolerated/appropriate) for adults with moderately-to-severely active RA with an inadequate response or intolerance to ≥ 1 conventional synthetic disease-modifying antirheumatics (csDMARD). The recommended dose is 200 mg every 2 weeks (q2w) with dose reduction to 150 mg if required for management of laboratory abnormalities. Three randomised controlled trials (RCTs) of subcutaneous sarilumab 150 or 200 mg q2w vs comparators showed meaningful improvements in pain. This analysis assessed UP and RP in these trials. Methods RCTs evaluated sarilumab 150 and 200 mg q2w vs placebo (+csDMARDs: MOBILITY/NCT01061736 and TARGET/NCT01709578) and sarilumab 200 mg q2w vs adalimumab 40 mg q2w (MONARCH/NCT02332590). Post-hoc analyses calculated odds ratios (ORs) of UP (based on patient acceptable symptom state on a threshold of visual analog scale pain >40 mm [0-100]), RP (UP+C-reactive protein <10 mg/L), and RP-strict (RP + ≤1 swollen joint count [SJC]), and associations between pain and fatigue (FACIT-Fatigue) and disease activity (Health Assessment Questionnaire [HAQ], SJC and tender joint count [TJC]). P values are nominal. Results Across all three trials, sarilumab 150 and 200 mg q2w had lower odds of UP (p < 0.05; ORs 0.39-0.46 vs placebo and 0.54 vs adalimumab). In MOBILITY, sarilumab 150 and 200 mg q2w had lower odds (p < 0.05) of RP vs placebo at Week 24 (ORs 0.60 [0.38,0.93] and 0.57 [0.37,0.87]) and Week 52 (ORs 0.64 [0.37,1.02] and 0.62 [0.37,1.02]), and RP-strict at Week 52 (0.41 [0.19,0.90] and 0.35 [0.16,0.76]). In TARGET, sarilumab 150 mg q2w had lower odds (p < 0.05) of RP-strict at Week 24. Higher pain was associated with worse FACIT-fatigue, HAQ, SJC and TJC scores (all p < 0.001). Conclusion Sarilumab was associated with lower odds of UP or RP vs adalimumab or placebo. Disclosures V. Bykerk: Consultancies; Abbvie, Amgen, Brainstorm Therapeutics, Bristol-Myers Squibb, Genentech, Gilead, Pfizer, Regeneron Pharmaceuticals, Inc., Sanofi, Scipher, Union Chimique Belge. Shareholder/stock ownership; Abbvie, Amgen, Brainstorm Therapeutics, Bristol-Myers Squibb, Genentech, Gilead, Pfizer, Regeneron Pharmaceuticals, Inc., Sanofi, Scipher, Union Chimique Belge. Grants/research support; AbbVie, Amgen, Brainstorm Therapeutics, Bristol-Myers Squibb, Genentech, Gilead, Pfizer, Regeneron Pharmaceuticals, Inc., Sanofi, Scipher, Union Chimique Belge. W. Wei: Shareholder/stock ownership; Regeneron Pharmaceuticals, Inc. Other; Regeneron Pharmaceuticals, Inc. S. Boklage: Shareholder/stock ownership; Regeneron Pharmaceuticals, Inc. Other; Regeneron Pharmaceuticals, Inc. T. Kimura: Shareholder/stock ownership; Regeneron Pharmaceuticals, Inc. Other; Regeneron Pharmaceuticals, Inc. S. Fiore: Shareholder/stock ownership; Sanofi. Other; Sanofi. G. St John: Shareholder/stock ownership; Regeneron Pharmaceuticals, Inc. Other; Regeneron Pharmaceuticals, Inc.