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Journal articles on the topic 'Visual therapies'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Duncan, Jacque L. "Visual Consequences of Delivering Therapies to the Subretinal Space." JAMA Ophthalmology 135, no. 3 (2017): 242. http://dx.doi.org/10.1001/jamaophthalmol.2016.5659.

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Davila-Siliezar, Pamela, Noor Laylani, Konstantinos AA Douglas, Dan Milea, and Andrew G. Lee. "Current and Emerging Therapies for Leber Hereditary Optic Neuropathy." US Ophthalmic Review 17, no. 1 (2023): 21. http://dx.doi.org/10.17925/usor.2023.17.1.21.

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Leber hereditary optic neuropathy (LHON) is the most common primary mitochondrial DNA disorder, presenting typically as a sequential, painless, subacute, optic neuropathy in young males. Despite the very limited therapeutic options in LHON, recent developments involving novel pharmacological agents and emerging gene therapy interventions have shown promising results for improved visual outcomes. A synthetic analogue of coenzyme Q (idebenone) is the most common medical treatment in LHON. In a multicentre, double-blind randomized, placebo-controlled clinical trial (Rescue of Hereditary Optic Dis

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Nguyen, Xuan-Thanh-An, Lude Moekotte, Astrid S. Plomp, Arthur A. Bergen, Maria M. van Genderen, and Camiel J. F. Boon. "Retinitis Pigmentosa: Current Clinical Management and Emerging Therapies." International Journal of Molecular Sciences 24, no. 8 (2023): 7481. http://dx.doi.org/10.3390/ijms24087481.

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Retinitis pigmentosa (RP) comprises a group of inherited retinal dystrophies characterized by the degeneration of rod photoreceptors, followed by the degeneration of cone photoreceptors. As a result of photoreceptor degeneration, affected individuals experience gradual loss of visual function, with primary symptoms of progressive nyctalopia, constricted visual fields and, ultimately, central vision loss. The onset, severity and clinical course of RP shows great variability and unpredictability, with most patients already experiencing some degree of visual disability in childhood. While RP is c

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Villegas, Victor M., and Stephen G. Schwartz. "Current and Future Pharmacologic Therapies for Diabetic Retinopathy." Current Pharmaceutical Design 24, no. 41 (2019): 4903–10. http://dx.doi.org/10.2174/1381612825666190130140717.

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Background: Currently, diabetic retinopathy is the leading cause of permanent visual loss in workingage adults in industrialized nations. The chronic microangiopathic changes associated with diabetic retinopathy lead to the most common causes of severe permanent visual loss: diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR). Multiple studies have evaluated different pharmacotherapies for different levels of retinopathy. Methods: A review of the pathophysiology of diabetic retinopathy and current and emerging pharmacotherapies for diabetic retinopathy. Results: Historica

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Lotery, Andrew J. "Long-term Therapies for Diabetic Macular Edema." European Ophthalmic Review 06, no. 04 (2012): 236. http://dx.doi.org/10.17925/eor.2012.06.04.236.

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Diabetic macular edema (DME) is one of the main causes of visual loss in diabetic patients. Although photocoagulation and intensive control of systemic metabolic factors have achieved improved outcomes, improvement is slow and some patients with DME continue to lose vision despite treatment. Pharmacological treatment options for DME include vascular endothelial growth factor (VEGF) antagonists such as ranibizumab, bevacizumab and pegaptanib and corticosteroids, whose multiple mechanisms of action include reduction of VEGF expression. Intravitreal delivery of these agents has shown efficacy in

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Carlos, Ignacio Sarmiento, and B. Surya Prasath V. "BRAIN Journal - Design of a Novel Servo-motorized Laser Device for Visual Pathways Diseases Therapy." BRAIN - Broad Research in Artificial Intelligence and Neuroscience 6, no. 1-2 (2015): 84–90. https://doi.org/10.5281/zenodo.1044147.

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ABSTRACT We discuss a novel servo-motorized laser device and a research protocol for visual pathways diseases therapies. The proposed servo-mechanized laser device can be used for potential rehabilitation of patients with hemianopia, quadrantanopia, scotoma and some types of cortical damages. The device uses a semi spherical structure where the visual stimulus will be shown inside, according to a previous stimuli therapy designed by an ophthalmologist or neurologist. The device uses a pair of servomotors (with torque=1.5kg), which controls the laser stimuli position for the internal therapy an

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Collin, Rob W. J., and Alejandro Garanto. "Preface of Special Issue "Molecular Therapies for Inherited Retinal Diseases"." Genes 11, no. 2 (2020): 169. http://dx.doi.org/10.3390/genes11020169.

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Lawton, Teri, John Shelley-Tremblay, Roland R. Lee, and Ming-Xiong Huang. "Retraining Dorsal Visual Pathways Improves Cognitive Skills After a Mild Traumatic Brain Injury." Journal of Clinical Medicine 14, no. 7 (2025): 2273. https://doi.org/10.3390/jcm14072273.

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Background and Objectives: Currently, there are no proven solutions to remediate cognitive deficits in people with a mild traumatic brain injury (mTBI). One common issue is visual timing deficits, which may be due to processing deficits in dorsal visual pathways. Methods: This study investigates whether a new intervention (PATH) aimed at improving these visual timing deficits is more effective than conventional cognitive therapies that either remediate: (1) pattern discrimination deficits (ventral visual pathway): Orientation Discrimination (OD), or (2) working memory deficits using ReCollect

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Barriga-Rivera, Alejandro, and GreggJ Suaning. "Visual prostheses, optogenetics, stem cell and gene therapies: splitting the cake." Neural Regeneration Research 13, no. 5 (2018): 805. http://dx.doi.org/10.4103/1673-5374.232469.

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Elhusseiny, Abdelrahman M., Mohammad Soleimani, Taher K. Eleiwa, et al. "Current and Emerging Therapies for Limbal Stem Cell Deficiency." Stem Cells Translational Medicine 11, no. 3 (2022): 259–68. http://dx.doi.org/10.1093/stcltm/szab028.

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Abstract The corneal epithelium serves to protect the underlying cornea from the external environment and is essential for corneal transparency and optimal visual function. Regeneration of this epithelium is dependent on a population of stem cells residing in the basal layer of the limbus, the junction between the cornea and the sclera. The limbus provides the limbal epithelial stem cells (LESCs) with an optimal microenvironment, the limbal niche, which strictly regulates their proliferation and differentiation. Disturbances to the LESCs and/or their niche can lead to the pathologic condition

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Kazemzadeh, Kimia. "Choroidal melanoma treatment: a shift towards vision preservation." Medical hypothesis, discovery & innovation in optometry 5, no. 3 (2025): 136–44. https://doi.org/10.51329/mehdioptometry208.

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Background: Choroidal melanoma is the most common primary intraocular malignancy in adults, and is known for its aggressive nature and potential for metastasis. Historically, enucleation was the primary treatment, which resulted in significant morbidity and psychological distress. Recent advances have led to a paradigm shift towards vision-preserving therapies. This review aimed to explore advances in choroidal melanoma treatment and their impact on patient care and quality of life. Methods: For this narrative review, we conducted a literature search of major databases, including PubMed/MEDLIN

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Lim, Jennifer I. "Unmet Needs in Diabetic Macular Edema." US Ophthalmic Review 04, no. 01 (2011): 101. http://dx.doi.org/10.17925/usor.2011.04.01.101.

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Purpose:The purpose of this article was to review current therapies for diabetic macular edema (DME) and to discuss current unmet needs in the treatment of DME.Methods:The peer-reviewed literature was searched for information about the results of clinical trials on the treatment of DME. The Internet, Retina Society meeting abstracts, and publications (both peer-reviewed and non-peer-reviewed) were searched for information about ongoing clinical trials on the treatment of DME.Results:Laser photocoagulation until recently was the only treatment with proven efficacy in phase III randomized clinic

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Karanja J., Otieno. "Measuring the Efficacy of Arts-Based Therapies." RESEARCH INVENTION JOURNAL OF SCIENTIFIC AND EXPERIMENTAL SCIENCES 4, no. 3 (2024): 16–22. https://doi.org/10.59298/rijses/2024/431622.

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Arts-based therapies harness creative expression through mediums such as music, dance, drama, and visual arts to promote emotional and psychological well-being. With roots in ancient healing practices and informed by interdisciplinary frameworks, these therapies have demonstrated efficacy across diverse populations, from individuals with autism to those experiencing trauma or terminal illnesses. This paper examines the theoretical foundations, clinical applications, and research methodologies employed to evaluate arts-based therapies. While both quantitative and qualitative approaches offer va

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Ishikawa, Makoto, Daisuke Jin, Yu Sawada, Sanae Abe, and Takeshi Yoshitomi. "Future Therapies of Wet Age-Related Macular Degeneration." Journal of Ophthalmology 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/138070.

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Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly population, and the prevalence of the disease increases exponentially with every decade after the age of 50 years. While VEGF inhibitors are promising drugs for treating patients with ocular neovascularization, there are limitations to their potential for improving vision in AMD patients. Thus, future therapies are required to have the potential to improve visual outcomes. This paper will summarize the future strategies and therapeutic targets that are aimed at enhancing the efficacy and duration of effect

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Haagdorens, Michel, Sara Ilse Van Acker, Veerle Van Gerwen, et al. "Limbal Stem Cell Deficiency: Current Treatment Options and Emerging Therapies." Stem Cells International 2016 (2016): 1–22. http://dx.doi.org/10.1155/2016/9798374.

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Severe ocular surface disease can result in limbal stem cell deficiency (LSCD), a condition leading to decreased visual acuity, photophobia, and ocular pain. To restore the ocular surface in advanced stem cell deficient corneas, an autologous or allogenic limbal stem cell transplantation is performed. In recent years, the risk of secondary LSCD due to removal of large limbal grafts has been significantly reduced by the optimization of cultivated limbal epithelial transplantation (CLET). Despite the great successes of CLET, there still is room for improvement as overall success rate is 70% and

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Kraus, Courtney L., and Susan M. Culican. "New advances in amblyopia therapy II: refractive therapies." British Journal of Ophthalmology 102, no. 12 (2018): 1611–14. http://dx.doi.org/10.1136/bjophthalmol-2018-312173.

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The treatment of anisometropic or ametropic amblyopia has traditionally enjoyed a high treatment success rate. Early initiation and consistent use of spectacle correction can completely resolve amblyopia in a majority of patients. For those with anisometropic amblyopia that fail to improve with glasses wear alone, patching or atropine penalisation can lead to equalisation of visual acuity. However, successful treatment requires full-time compliance with refractive correction and this can be a challenge for a patient population that often has one eye with good acuity without correction. Other b

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Adelman, Ron, Aaron Parnes, Zofia Michalewska, Barbara Parolini, Claude Boscher, and Didier Ducournau. "Strategy for the Management of Diabetic Macular Edema: The European Vitreo-Retinal Society Macular Edema Study." BioMed Research International 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/352487.

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Objective. To compare the efficacy of different therapies in the treatment of diabetic macular edema (DME).Design. Nonrandomized, multicenter clinical study.Participants. 86 retina specialists from 29 countries provided clinical information on 2,603 patients with macular edema including 870 patients with DME.Methods. Reported data included the type and number of treatment(s) performed, the pre- and posttreatment visual acuities, and other clinical findings. The results were analyzed by the French INSEE (National Institute of Statistics and Economic Studies).Main Outcome Measures. Mean change o

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18

Bricker, Rebecca. "Stem Cell Therapies for Sensory Organ Disorders." Science Reviews. Biology 1, no. 2 (2023): 9–19. http://dx.doi.org/10.57098/scirevs.biology.1.2.2.

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Sensory organ disorders, such as visual impairment, hearing loss, and olfactory dysfunction, affect a significant percentage of the population. There are no effective therapies to restore cell damage and tissue function to these sensory organs. Human pluripotent stem cells (hPSCs) have the potential to expand out to an unlimited number of cells and differentiate into any cell type of the body, and therefore have high potential to restore tissue function in transplantation stem cell therapies for sensory organ disorders. This review elaborates on the specific sensory cells for the vision, audit

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19

Quiram, Polly A., and Yahui Song. "Exudative Age-Related Macular Degeneration: Current Therapies and Potential Treatments." Clinical Medicine. Therapeutics 1 (January 2009): CMT.S2225. http://dx.doi.org/10.4137/cmt.s2225.

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Strategies for preventing vision loss in patients with neovascular age-related macular degeneration (ARMD) have evolved over the past decade. Whereas earlier treatments were based on thermal destruction of choroidal neovascularization (CNV), new therapies rely on targeted pharmacologic approaches to reduce the harmful effects of CNV treatment. For the first time in the history of neovascular ARMD treatment, anti-VEGF therapies have consistently improved visual acuity in a subset of patients. Clinical trials continue to investigate the optimal dosing strategies and combination therapies to bett

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20

Tomczak, Wojciech, Weronika Winkler-Lach, Martyna Tomczyk-Socha, and Marta Misiuk-Hojło. "Advancements in Ocular Regenerative Therapies." Biology 12, no. 5 (2023): 737. http://dx.doi.org/10.3390/biology12050737.

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The use of stem cells (SCs) has emerged as a promising avenue in ophthalmology, offering potential therapeutic solutions for various vision impairments and degenerative eye diseases. SCs possess the unique ability to self-renew and differentiate into specialised cell types, making them valuable tools for repairing damaged tissues and restoring visual function. Stem cell-based therapies hold significant potential for addressing conditions such as age-related macular degeneration (AMD), retinitis pigmentosa (RP), corneal disorders, and optic nerve damage. Therefore, researchers have explored dif

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Borchert, Grace A., Hoda Shamsnajafabadi, Monica L. Hu, et al. "The Role of Inflammation in Age-Related Macular Degeneration—Therapeutic Landscapes in Geographic Atrophy." Cells 12, no. 16 (2023): 2092. http://dx.doi.org/10.3390/cells12162092.

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Age-related macular degeneration (AMD) is the leading cause of vision loss and visual impairment in people over 50 years of age. In the current therapeutic landscape, intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapies have been central to the management of neovascular AMD (also known as wet AMD), whereas treatments for geographic atrophy have lagged behind. Several therapeutic approaches are being developed for geographic atrophy with the goal of either slowing down disease progression or reversing sight loss. Such strategies target the inflammatory pathways, complement

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Pradhan, Shaili, Regina Shrestha, and Ranjita Shrestha Gorkhali. "Pain Perception after Periodontal Therapies." Journal of Nepalese Society of Periodontology and Oral Implantology 2, no. 2 (2018): 56–60. http://dx.doi.org/10.3126/jnspoi.v2i2.23615.

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Background: Pain perception is a complex sensory experience which is perceived by different individuals in different manners. The pain perceived by the patient after periodontal surgery may vary based on different parameters. Aim: This observational study was conducted to evaluate the perception of pain after periodontal therapies. Materials and Methods: A total of 63 surgeries were carried out in 50 patients and the surgeries were divided into three categories: open flap debridement, resective and regenerative surgeries, and periodontal plastic surgeries. The pain experienced by t

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Cosmo, Eleonora, Elisabetta Pilotto, Enrica Convento, Federico Parolini, and Edoardo Midena. "Microperimetry Sensitivity Correlates to Structural Macular Changes in Adolescents with Achromatopsia Unlike Other Visual Function Tests." Journal of Clinical Medicine 13, no. 19 (2024): 5968. http://dx.doi.org/10.3390/jcm13195968.

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Objectives: Achromatopsia (ACHM) is a rare autosomal, recessively inherited disease that is characterized by cone dysfunction, for which several gene therapies are currently on trial. The aim of this study was to find correlations between the morphological macular changes identified using optical coherence tomography (OCT) and some visual functional parameters. Visual acuity (VA), contrast sensitivity (CS), and macular sensitivity obtained by means of microperimetry were assessed. Methods: Adolescents with ACHM underwent macular microperimetry (S-MAIA device) in mesopic condition, macular OCT,

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Kaštelan, Snježana. "Special Issue “The Molecular and Cellular Pathophysiologic Mechanisms Underlying Ocular Diseases and Emerging Therapies”." International Journal of Molecular Sciences 25, no. 4 (2024): 2405. http://dx.doi.org/10.3390/ijms25042405.

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25

Nolan, Rachel C., Omar Akhand, John-Ross Rizzo, Steven L. Galetta, and Laura J. Balcer. "Evolution of Visual Outcomes in Clinical Trials for Multiple Sclerosis Disease-Modifying Therapies." Journal of Neuro-Ophthalmology 38, no. 2 (2018): 202–9. http://dx.doi.org/10.1097/wno.0000000000000662.

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Rosado, Amaris, Ediel Rodriguez, and Natalio Izquierdo. "Ophthalmologic Manifestations in Bardet–Biedl Syndrome: Emerging Therapeutic Approaches." Medicina 61, no. 7 (2025): 1135. https://doi.org/10.3390/medicina61071135.

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Bardet–Biedl syndrome (BBS) is a rare multisystem ciliopathy characterized by early-onset retinal degeneration and other vision-threatening ophthalmologic manifestations. This review synthesizes current knowledge on the ocular phenotype of BBS as well as emerging therapeutic approaches aimed at preserving visual function. Retinal degeneration, particularly early macular involvement and rod–cone dystrophy, remains the hallmark of BBS-related vision loss. Additional ocular manifestations, such as refractive errors, nystagmus, optic nerve abnormalities, and cataracts further contribute to visual

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K, Sreekumar, Greeshma K U, and Jaseela V P. "EFFECTIVENESS OF LOCAL AYURVEDIC THERAPEUTICS IN THE MANAGEMENT OF PROLIFERATIVE DIABETIC RETINOPATHY – A CASE REPORT." International Ayurvedic Medical Journal 12, no. 10 (2024): 1925–32. https://doi.org/10.46607/iamj2012102024.

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Proliferative diabetic retinopathy (PDR) is a severe complication of diabetes mellitus, often leading to significant vision loss despite conventional treatments such as photocoagulation and intravitreal injections. This case report evaluates the effectiveness of local Ayurvedic therapies in managing PDR in a 55-year-old male with a 28-year history of Type 2 diabetes along with hypertension, hypercholesterolemia, and chronic smoking. Despite undergoing multiple conventional treatments with minimal improvement, the patient sought alternative management through Ayurveda. The Ayurvedic treatment r

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Renuks Sarwate, Rohit Kundap, Girish Arun Gadre, Prajakta Patil, D. B. Shirke,. "Emerging Therapies in Retinal Diseases: From Gene Therapy to Stem Cell Interventions." International Journal on Recent and Innovation Trends in Computing and Communication 11, no. 7 (2023): 381–86. http://dx.doi.org/10.17762/ijritcc.v11i7.9421.

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Retinal disorders pose a serious threat to eye health as they frequently result in blindness and reduced vision. There is hope that the treatment of many illnesses will be revolutionised by emerging medicines, especially gene therapy and stem cell approaches. This study explores the current state of these innovative therapies and how they could affect retinal disorders. By replacing or repairing damaged genes, gene therapy, which uses precise genetic modification, shows promise in treating hereditary retinal problems. Clinical trials have yielded promising results, including improvements in vi

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Adelman, Ron A., Aaron J. Parnes, Silvia Bopp, Ihab Saad Othman, and Didier Ducournau. "Strategy for the Management of Macular Edema in Retinal Vein Occlusion: The European VitreoRetinal Society Macular Edema Study." BioMed Research International 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/870987.

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Objective. To compare the efficacy of different therapies in the treatment of macular edema associated with retinal vein occlusion (RVO).Design. This is a nonrandomized, multicenter collaborative study.Participants. 86 retina specialists from 29 countries provided clinical information, including choice of treatment and outcome, on 2,603 patients with macular edema including 738 cases of RVO.Methods. Reported data included the type and number of treatments performed, visual acuities, and other clinical and diagnostic findings.Main Outcome Measures. The mean increase in visual acuity and mean nu

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Amissah-Arthur, Kwesi Nyan. "Challenges with starting vitreoretinal services in the developing world." Nepalese Journal of Ophthalmology 8, no. 1 (2016): 1–2. http://dx.doi.org/10.3126/nepjoph.v8i1.16160.

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Service development and improvement within ophthalmology has taken a whole new dimension with the constant improvement of equipment, and the development of therapies that significantly improve the management of our patients and as such alters their visual prognosis for the better. This improvement and increased reliance on both diagnostic and surgical equipment with the concomitant use of intravitreal therapies has arguably been felt more in the field of retinal diseases. Nepal J Ophthalmol 2016; 8(15): 1-2

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Armstrong, R. A. "Visual Symptoms in Parkinson's Disease." Parkinson's Disease 2011 (2011): 1–9. http://dx.doi.org/10.4061/2011/908306.

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Parkinson's disease (PD) is a common disorder of middle-aged and elderly people in which degeneration of the extrapyramidal motor system causes significant movement problems. In some patients, however, there are additional disturbances in sensory systems including loss of the sense of smell and auditory and/or visual problems. This paper is a general overview of the visual problems likely to be encountered in PD. Changes in vision in PD may result from alterations in visual acuity, contrast sensitivity, colour discrimination, pupil reactivity, eye movements, motion perception, visual field sen

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Chen, Yi-Hsing, Sue Lightman, Malihe Eskandarpour, and Virginia L. Calder. "Adhesion Molecule Targeted Therapy for Non-Infectious Uveitis." International Journal of Molecular Sciences 23, no. 1 (2022): 503. http://dx.doi.org/10.3390/ijms23010503.

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Non-infectious uveitis (NIU) is an inflammatory eye disease initiated via CD4+ T-cell activation and transmigration, resulting in focal retinal tissue damage and visual acuity disturbance. Cell adhesion molecules (CAMs) are activated during the inflammatory process to facilitate the leukocyte recruitment cascade. Our review focused on CAM-targeted therapies in experimental autoimmune uveitis (EAU) and NIU. We concluded that CAM-based therapies have demonstrated benefits for controlling EAU severity with decreases in immune cell migration, especially via ICAM-1/LFA-1 and VCAM-1/VLA-4 (integrin)

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Lambe, Jeffrey, Shiv Saidha, and Robert A. Bermel. "Optical coherence tomography and multiple sclerosis: Update on clinical application and role in clinical trials." Multiple Sclerosis Journal 26, no. 6 (2019): 624–39. http://dx.doi.org/10.1177/1352458519872751.

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Optical coherence tomography (OCT) has emerged as a fast, non-invasive, inexpensive, high-resolution imaging technique in multiple sclerosis (MS). Retinal layer quantification by OCT facilitates a ‘window’ into not only local retinal pathology but also global neurodegenerative processes, recognised to be the principal substrates of disability accumulation in MS. While OCT measures in MS have been demonstrated to reflect visual function, inflammatory activity outside of the visual pathways, disability measures including the prediction of disability progression, whole brain atrophy, and the diff

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Dal Bello, Simone, Deborah Martinuzzi, Yan Tereshko, et al. "The Present and Future of Optic Pathway Glioma Therapy." Cells 12, no. 19 (2023): 2380. http://dx.doi.org/10.3390/cells12192380.

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Optic pathway gliomas (OPGs) encompass two distinct categories: benign pediatric gliomas, which are characterized by favorable prognosis, and malignant adult gliomas, which are aggressive cancers associated with a poor outcome. Our review aims to explore the established standards of care for both types of tumors, highlight the emerging therapeutic strategies for OPG treatment, and propose potential alternative therapies that, while originally studied in a broader glioma context, may hold promise for OPGs pending further investigation. These potential therapies encompass immunotherapy approache

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Wen, Yao-Tseng, Yu-Chieh Ho, Yueh-Chang Lee, Dah-Ching Ding, Pei-Kang Liu, and Rong-Kung Tsai. "The Benefits and Hazards of Intravitreal Mesenchymal Stem Cell (MSC) Based-Therapies in the Experimental Ischemic Optic Neuropathy." International Journal of Molecular Sciences 22, no. 4 (2021): 2117. http://dx.doi.org/10.3390/ijms22042117.

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Mesenchymal stem cell (MSC) therapy has been investigated intensively for many years. However, there is a potential risk related to MSC applications in various cell niches. Methods: The safety of intravitreal MSC application and the efficacy of MSC-derived conditioned medium (MDCM) were evaluated in the normal eye and the diseased eye, respectively. For safety evaluation, the fundus morphology, visual function, retinal function, and histological changes of the retina were examined. For efficacy evaluation, the MDCM was intravitreally administrated in a rodent model of anterior ischemic optic n

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Magalhães, Augusto, Ana Maria Cunha, Rodrigo Vilares-Morgado, et al. "Macular Changes in a Mucopolysaccharidosis Type I Patient with Earlier Systemic Therapies." Case Reports in Ophthalmological Medicine 2021 (April 12, 2021): 1–7. http://dx.doi.org/10.1155/2021/8866837.

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Purpose. To describe retinal findings in a patient with mucopolysaccharidosis type I (MPS I) that underwent an early treatment with hematopoietic stem cell transplantation (HSCT) and enzyme replacement therapy (ERT). Case Report. We describe a case of a 12-year-old female with a biochemical and genetic diagnosis of MPS I. She underwent HSCT and ERT on the first year of life. The visual acuity was 5/10 in both eyes and she had bilateral grade 2 corneal haze. Spectral domain optical coherence tomography (SD-OCT) revealed thickening of the external limiting membrane (ELM) at the fovea. In the par

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Modi, Yasha S., Michael A. Klufas, Jayanth Sridhar, Rishi P. Singh, Yoshihiro Yonekawa, and Paula Pecen. "Current Best Clinical Practices—Management of Retinal Vein Occlusion." Journal of VitreoRetinal Diseases 4, no. 3 (2020): 214–19. http://dx.doi.org/10.1177/2474126420906395.

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Retinal vein occlusion (RVO) is the second most common cause of vision loss from retinal vascular diseases in adults in the United States. Visual loss arises as a result of a host of factors, including macular ischemia and macular edema. Primary antivascular endothelial growth factor therapy is the current standard of care, with level I evidence demonstrating sustained visual gains up to 2 years after treatment in both branch and central RVO. Prompt antivascular endothelial growth factor therapy is important because delays in treatment yield lesser visual gains. Steroid therapy also improves v

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Sacconi, Riccardo, Chiara Giuffrè, Eleonora Corbelli, Enrico Borrelli, Giuseppe Querques, and Francesco Bandello. "Emerging therapies in the management of macular edema: a review." F1000Research 8 (August 12, 2019): 1413. http://dx.doi.org/10.12688/f1000research.19198.1.

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Macular edema (ME) is a major complication of several vascular and inflammatory retinal diseases. Multiple mechanisms are implicated in its development and lead to visual impairment that could be reversible (the acute stages) or not reversible (long-standing ME). For this reason, an effective approach to the treatment of ME is of paramount importance in order to prevent irreversible damage of visual function. In this review, we discuss the management of ME and, in particular, current data of studies and clinical trials about drugs that have already been evaluated or are under investigation in

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Coco-Martin, María B., David P. Piñero, Luis Leal-Vega, et al. "The Potential of Virtual Reality for Inducing Neuroplasticity in Children with Amblyopia." Journal of Ophthalmology 2020 (June 29, 2020): 1–9. http://dx.doi.org/10.1155/2020/7067846.

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In recent years, virtual reality (VR) has emerged as a new safe and effective tool for neurorehabilitation of different childhood and adulthood conditions. VR-based therapies can induce cortical reorganization and promote the activation of different neuronal connections over a wide range of ages, leading to contrasted improvements in motor and functional skills. The use of VR for the visual rehabilitation in amblyopia has been investigated in the last years, with the potential of using serious games combining perceptual learning and dichoptic stimulation. This combination of technologies allow

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Iwuh, John, Victorine Chinwe Obia, Dominic OluGbenga Fayenuwo, et al. "Film As Therapy for Defied Children: Hell as Pedagogy for Sex Abuse in Dry and The Colour Purple." International Journal of Religion 5, no. 10 (2024): 1799–807. http://dx.doi.org/10.61707/1bvt3550.

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Child abuse is a threat that impedes the mental health of victims. In Nigeria, rape and other sexual violence are prevalent. It has become a silent killer due to stigma and emotional torture, attracting Nigerian filmmakers’ attention. This article focused on the ordeal associated with sexual abuse of the girl-child given her vulnerability. However, the cure and management of the repercussions of abuse have been more medical than visual therapies such as film. However, art-based research has shown that visual therapies are also incontrovertible alternatives to pharmaceutically based treatments.

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Xiong, Jun, Guiling Liang, Liang Hu, et al. "Transient visual acuity loss after spine surgery in the prone position: a case report and literature review." Journal of International Medical Research 48, no. 9 (2020): 030006052095227. http://dx.doi.org/10.1177/0300060520952279.

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Visual loss after spine surgery in the prone position is a disastrous postoperative complication because it is almost irreversible. Additionally, the optimal treatments and recommended professional guidelines for visual loss after spine surgery are deficient. A 43-year-old man developed visual loss after spine surgery in the prone position. Immediate ophthalmic consultation confirmed central retinal artery occlusion. Therefore, combined therapies were administered, including neurotrophy, anticoagulation, vasodilation, and adequate fluid infusion, followed by hyperbaric oxygen treatment. After

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Martínez-Lapiscina, E. H., B. Sanchez-Dalmau, E. Fraga-Pumar, et al. "The visual pathway as a model to understand brain damage in multiple sclerosis." Multiple Sclerosis Journal 20, no. 13 (2014): 1678–85. http://dx.doi.org/10.1177/1352458514542862.

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Patients with multiple sclerosis (MS) almost always experience effects in the visual pathway; and thus, visual dysfunction is not only common but also highly relevant. The visual pathway represents a model of acute focal central nervous system (CNS) damage, through acute optic neuritis and retinal periphlebitis, as well as a model of chronic, diffuse CNS damage through chronic retinopathy and optic neuropathy. The optic pathway can be accurately evaluated in detail, due to the availability of highly sensitive imaging techniques (e.g. magnetic resonance imaging or optical coherent tomography) o

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Risso, Wellington Fernando, Matheus Roque Pinheiro, Leonardo Amarante Pereira, et al. "Diabetic macular edema: a literature review." ABCS Health Sciences 45, Suppl.3 (2020): e020108. http://dx.doi.org/10.7322/abcshs.2020s08.1855.

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Diabetic Macular Edema is a major cause of visual impairment in economically active population, being responsible for a significant impact in quality of life in the affected population, as well as high costs to the health care system. Over decades, some studies have compared treatments using Laser, Anti-VEGF and intravitreous corticosteroids, establishing protocols to reach effectives therapies. Thus, it is essential an entire understanding of available therapies to reach the goal of disease control, in an individual basis and in a collective health care system, as efficient as possible.

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Keehn, Caroline C., Arman Yazdian, Patrick J. Hunt, Pamela Davila-Siliezar, Noor A. Laylani, and Andrew G. Lee. "Monoclonal antibodies in neuro-ophthalmology." Saudi Journal of Ophthalmology 38, no. 1 (2024): 13–24. http://dx.doi.org/10.4103/sjopt.sjopt_256_23.

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Abstract: Neuro-ophthalmologic diseases include a broad range of disorders affecting the afferent and efferent visual pathways. Recently, monoclonal antibody (mAb) therapies have emerged as a promising targeted approach in the management of several of these complex conditions. Here, we describe the mechanism-specific applications and advancements in neuro-ophthalmologic mAb therapies. The application of mAbs in neuro-ophthalmologic diseases highlights our increasing understanding of disease-specific mechanisms in autoimmune conditions such as neuromyelitis optica, thyroid eye disease, and myas

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Ullrich, Franziska, Stefano Fusco, George Chatzipirpiridis,, Salvador Pané, and Bradley J. Nelson. "Recent Progress in Magnetically Actuated Microrobotics for Ophthalmic Therapies." European Ophthalmic Review 08, no. 02 (2014): 120. http://dx.doi.org/10.17925/eor.2014.08.02.120.

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Age-related visual loss and ageing demographics account for a large impact on societal health costs on a global scale. Efficient ocular surgery must be precise, safe and cost effective. Current research focuses on robotic systems to assist in ophthalmic surgery. Furthermore, several platforms for drug delivery in the posterior segment of the eye have been introduced. Moreover, magnetic manipulation of tethered and untethered structures has been suggested to assist in teleoperated ophthalmic surgery and targeted drug delivery in the posterior eye due to its many advantages. Magnetic manipulatio

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Mélik Parsadaniantz, Stéphane, Annabelle Réaux-le Goazigo, Anaïs Sapienza, Christophe Habas, and Christophe Baudouin. "Glaucoma: A Degenerative Optic Neuropathy Related to Neuroinflammation?" Cells 9, no. 3 (2020): 535. http://dx.doi.org/10.3390/cells9030535.

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Glaucoma is one of the leading causes of irreversible blindness in the world and remains a major public health problem. To date, incomplete knowledge of this disease’s pathophysiology has resulted in current therapies (pharmaceutical or surgical) unfortunately having only a slowing effect on disease progression. Recent research suggests that glaucomatous optic neuropathy is a disease that shares common neuroinflammatory mechanisms with “classical” neurodegenerative pathologies. In addition to the death of retinal ganglion cells (RGCs), neuroinflammation appears to be a key element in the progr

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Yang, Tsai-Hsuan, Eugene Yu-Chuan Kang, Pei-Hsuan Lin, et al. "Mitochondria in Retinal Ganglion Cells: Unraveling the Metabolic Nexus and Oxidative Stress." International Journal of Molecular Sciences 25, no. 16 (2024): 8626. http://dx.doi.org/10.3390/ijms25168626.

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This review explored the role of mitochondria in retinal ganglion cells (RGCs), which are essential for visual processing. Mitochondrial dysfunction is a key factor in the pathogenesis of various vision-related disorders, including glaucoma, hereditary optic neuropathy, and age-related macular degeneration. This review highlighted the critical role of mitochondria in RGCs, which provide metabolic support, regulate cellular health, and respond to cellular stress while also producing reactive oxygen species (ROS) that can damage cellular components. Maintaining mitochondrial function is essentia

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TUNA, Halil İbrahim. "The Effects of Complementary Alternative Methods Used by Nursing Students on Coping with Stress." Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi 11, no. 4 (2022): 1460–65. http://dx.doi.org/10.37989/gumussagbil.848159.

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This study was conducted to determine the effect of complementary and alternative therapies used by nursing students on coping with stress. The study was conducted with 184 students who agreed to participate in the nursing department of a university between November 1-30, 2020. Data were collected on the internet. Descriptive features data form, form containing complementary alternative therapy usage features, and visual analog scale were used. The average stress score of the students was 3.04 ± 0.88, 60.3% experienced stress, 34.8% had stress-related constipation, 66.3% used a complementary a

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Tsaousis, Konstantinos T., Georgios Mousteris, Vasilios Diakonis, and Stergios Chaloulis. "Current Developments in the Management of Amblyopia with the Use of Perceptual Learning Techniques." Medicina 60, no. 1 (2023): 48. http://dx.doi.org/10.3390/medicina60010048.

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Background and Objectives: Amblyopia is a neurodevelopmental disorder caused by interocular suppression of visual input, affecting visual acuity, stereopsis, contrast sensitivity, and other visual functions. Conventional treatment comprises occlusion of the sound eye. In recent years, novel therapies that deploy perceptual learning (PL) principles have been introduced. The purpose of this study is to assess the latest scientific data on this topic. Materials and Methods: For this purpose, we conducted a literature search for relevant studies published during the previous 4 years (2020–2023). R

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Lantos, Krisztina, Zsuzsa Réka Dömötör, Nelli Farkas, et al. "Efficacy of Treatments in Nonarteritic Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis." International Journal of Environmental Research and Public Health 19, no. 5 (2022): 2718. http://dx.doi.org/10.3390/ijerph19052718.

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Background: Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) is the second most common cause of optic nerve-related permanent visual loss in adults. Aim: We aimed to analyze the efficacy of the noninvasive and minimally invasive therapeutic options of NAION. Methods: We performed a systematic literature search in MEDLINE, EMBASE, and CENTRAL from inception to 10 June 2019 to identify the studies that report on the effect of different therapies on visual acuity (VA) and visual field (VF). Weighted mean difference (WMD) with 95% confidence interval (CI) was calculated for these outcomes.

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