Relevant bibliographies by topics / Vitamin A deficiency – Zambia

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Academic literature on the topic 'Vitamin A deficiency – Zambia'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Vitamin A deficiency – Zambia"

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SATO, Yoshihiko, Markus SCHNEEBEL, and Gihei SATO. "An Occurrence of Vitamin A Deficiency in Chickens in Zambia." Journal of Veterinary Medical Science 54, no. 3 (1992): 601–3. http://dx.doi.org/10.1292/jvms.54.601.

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Hotz, Christine, Justin Chileshe, Ward Siamusantu, Uma Palaniappan, and Emmanuel Kafwembe. "Vitamin A intake and infection are associated with plasma retinol among pre-school children in rural Zambia." Public Health Nutrition 15, no. 9 (2012): 1688–96. http://dx.doi.org/10.1017/s1368980012000924.

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AbstractObjectiveTo determine the prevalence of vitamin A deficiency, infection and adequacy of vitamin A intakes among Zambian children, and the contribution of dietary vitamin A and infection to vitamin A status.DesignA cross-sectional survey of vitamin A intakes by the 24 h recall method, vitamin A status by plasma retinol and the modified relative dose-response test, and infection by acute-phase proteins.SettingRural communities in Central and Eastern Provinces of Zambia.SubjectsChildren 2–5 years of age.ResultsThe prevalence of vitamin A deficiency was 56 % by plasma retinol, 48 % with infection-adjusted plasma retinol and 22 % by the modified relative dose-response test. The majority of children (61 %) had a current infection. Vitamin A intakes were relatively high (331 to 585 μg retinol activity equivalents/d in the harvest/early post-harvest and late post-harvest seasons, respectively) and the prevalence of inadequate intakes was <1 % when compared with the Estimated Average Requirement (210 and 275 μg retinol activity equivalents/d for children aged 1–3 and 4–8 years, respectively). Elevated α-1-acid glycoprotein was negatively associated with plasma retinol (P< 0·0 0 1) and vitamin A intake was positively associated with plasma retinol (P< 0·05), but only when estimated assuming a 26:1 retinol equivalence for provitamin A from green and yellow vegetables.ConclusionsInfection and vitamin A intakes were significant determinants of plasma retinol. We cannot conclude which indicator more accurately represents the true vitamin A status of the population. Reasons for the persistent high prevalence of vitamin A deficiency in the presence of adequate vitamin A intakes are unclear, but the high rates of infection may play a role.
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Lopez-Teros, Veronica, Justin Chileshe, Nicole Idohou-Dossou, et al. "International Experiences in Assessing Vitamin A Status and Applying the Vitamin A-Labeled Isotope Dilution Method." International Journal for Vitamin and Nutrition Research 84, Supplement 1 (2014): 40–51. http://dx.doi.org/10.1024/0300-9831/a000184.

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Inadequate vitamin A (VA) nutrition continues to be a major problem worldwide, and many interventions being implemented to improve VA status in various populations need to be evaluated. The interpretation of results after an intervention depends greatly on the method selected to assess VA status. To evaluate the effect of an intervention on VA status, researchers in Cameroon, India, Indonesia, Mexico, Senegal and Zambia have used serum retinol as an indicator, and have not always found improvement in response to supplementation. One problem is that homeostatic control of serum retinol may mask positive effects of treatment in that changes in concentration are observed only when status is either moderately to severely depleted or excessive. Because VA is stored mainly in the liver, measurements of hepatic VA stores are the “gold standard” for assessing VA status. Dose response tests such as the relative dose response (RDR) and the modified relative dose response (MRDR), allow a qualitative assessment of VA liver stores. On the other hand, the use of the vitamin A-labeled isotope dilution (VALID) technique, (using 13C or 2H-labeled retinyl acetate) serves as an indirect method to quantitatively estimate total body and liver VA stores. Countries including Cameroon, China, Ghana, Mexico, Thailand and Zambia are now applying the VALID method to sensitively assess changes in VA status during interventions, or to estimate a population’s dietary requirement for VA. Transition to the use of more sensitive biochemical indicators of VA status such as the VALID technique is needed to effectively assess interventions in populations where mild to moderate VA deficiency is more prevalent than severe deficiency.
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Kafwembe, Emmanuel M., James Chipipa, Eric Njunju, and Roma Chilengi. "The Vitamin A Status of Zambian Children in a Community of Vitamin A Supplementation and Sugar Fortification Strategies as measured by the Modified Relative Dose Response (MRDR) Test." International Journal for Vitamin and Nutrition Research 79, no. 1 (2009): 40–47. http://dx.doi.org/10.1024/0300-9831.79.1.40.

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The main objective of the study was to determine the vitamin A status of Zambian children less than five years of age in a community where strategies of vitamin A supplementation and consumption of vitamin A fortified sugar have been introduced. In a cross-sectional study, a total of 537 children were enrolled. Their vitamin A status was measured using the modified relative dose response (MRDR) test. Their vitamin A status was compared to the status measured using a similar method in 1996, before vitamin A supplementation through capsule distribution and fortification of sugar was implemented as strategies to reduce vitamin A deficiency in the country. Results showed that the vitamin A status of children improved markedly as a result of these strategies.
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Sakala, Patricia, Ernesta Kunneke, and Mieke Faber. "Household Consumption of Orange-Fleshed Sweet Potato and its Associated Factors in Chipata District, Eastern Province Zambia." Food and Nutrition Bulletin 39, no. 1 (2017): 127–36. http://dx.doi.org/10.1177/0379572117729979.

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Background: The Integrating Orange Project promotes production and consumption of orange-fleshed sweet potato (OFSP) to address vitamin A deficiency among rural populations of Zambia since 2011. Objective: This study assessed household production and consumption of OFSP and identified factors associated with consumption thereof in Integrating Orange Project areas in Chipata district, Zambia. Methods: Respondents of 295 randomly selected households were interviewed using a structured questionnaire during the sweet potato harvest season. Associations between OFSP consumption and household factors were assessed using χ2 tests. Results: Frequency of OFSP consumption was categorized as ≥4 days during the last 7 days (30.2%), 1 to 3 days during the last 7 days (49.5%), eats OFSP but not during the last 7 days (7.1%), and never (13.2%). In total, 60.3% of households planted OFSP, and 40.0% bought OFSP, mostly from farmers within the community. Orange-fleshed sweet potato consumption was associated with the presence of children aged less than 5 years in the household ( P = .018), production of OFSP ( P < .001), purchasing of OFSP ( P < .001), and respondent having knowledge on health benefits of OFSP ( P = .014). Age and sex of the household head and household size had no association with OFSP consumption ( P > .05). Conclusion: A high percentage of households consumed OFSP during the harvesting season in Integrating Orange Project areas. Programs promoting OFSP consumption should thus focus on OFSP production and sensitizing households on nutritional benefits of OFSP and target households with children aged less than 5 years as entry point.
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Johnson, Catherine, Sophia Brown, Chandler Phelps, et al. "Metabolomics Identifies Serum Metabolites Different in Zambian Women with Adequate versus Deficient Total Liver Vitamin A Reserves Despite Adequate Serum Retinol Levels." Current Developments in Nutrition 5, Supplement_2 (2021): 73. http://dx.doi.org/10.1093/cdn/nzab034_007.

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Abstract Objectives Vitamin A deficiency (VAD) has remained a leading cause of morbidity and mortality throughout the world for decades, however there are still challenges defining VA status because the most common biomarker, serum retinol, is regulated homeostatically except in extreme deficiency and affected by inflammation; therefore, more accurate biomarkers to define VAD are needed. Furthermore, the effects of VAD on metabolism are still being uncovered. The objective was to investigate whether serum metabolomics profiles differed between Zambian women with adequate versus deficient VA status measured by the gold-standard biomarker total liver VA reserves (TLR) whose serum retinol concentrations did not differ. Methods Retinol isotope dilution (RID) was used to estimate TLR in Zambian women in the Rufunsa district; serum aliquots were selected for metabolomics based on adequate (TLR &gt; 0.1–1 μmol VA/g liver) or deficient (TLR &lt; 0.1 μmol/g) VA status (n = 10/group). Serum retinol levels were indicative of adequacy (&gt;0.7 μmol/L) and were not different between groups. Serum samples were analyzed by LC-MS using four metabolomics assays. Metabolomics data were covariate-adjusted for age and BMI. Results Ten metabolites were different between the adequate and deficient vitamin A groups (P &lt; 0.05). Metabolites lower in the deficient group included multiple phosphatidylcholines (PCs) and phosphatidylethanolamines (PEs), as well as lipoxygenase (LOX)-derived oxylipins (9-HODE and 17-HDoHE), choline, and anthranilic acid. One cholestryl ester was elevated in the deficient group. Conclusions The study revealed numerous metabolites altered by RID-measured VAD and adequacy despite similarly adequate serum retinol levels in both groups. Future research is required to investigate the mechanisms by which phospholipids such as PCs and PEs, as well as LOX-derived oxylipins, are altered by VA status and the potential use of these metabolites as biomarkers of VAD. Funding Sources University of Wisconsin-Madison Global Health Institute visiting scholar fellowship (CK and SAT).
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Komodromos, Marcos. "Interactive radio, social network sites and development in Africa: a literature review study." Journal of Enterprising Communities: People and Places in the Global Economy 15, no. 2 (2021): 282–95. http://dx.doi.org/10.1108/jec-06-2020-0111.

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Purpose The technology determinism theory facilitated in assessing the impact of interactive radio and social network sites (SNSs) on development factors such as education, agriculture, health, and governance, by conducting an integrative and comprehensive literature review focusing on African countries. This paper aims to conduct this literature review to provide comprehensive empirical evidence on the impact of interactive radio and SNSs on development in Africa. Design/methodology/approach This study examined articles that were retrieved from online databases including EBSCOhost, Elsevier, Science Direct, SAGE Journals, Springer and Wiley Online Library. The keywords used included interactive radio, radio, development in Africa, SNS, agriculture, education, health, peace and governance. Search phrases were formulated using boolean operators “AND” and “OR.” Findings Study results revealed that interactive radio and SNSs improve knowledge among farmers and allow the dissemination of information on innovative agricultural techniques, which supports the adoption of sustainable practices. Interactive radio promotes political accountability because the strategies provide the voiceless and powerless communities with a platform to express themselves. This paper discovers that the incorporation of SNS with existing multimedia communication facilitates the dissemination of health-related information on illnesses such as Ebola, HIV, hypertension, diabetes and Polio, and interactive radio and SNS promote education among marginalized communities and under-served rural schools. Research limitations/implications The findings on the impact of interactive radio and SNSs do not represent all 54 countries in Africa. Although the studies included in this literature review were conducted in several countries such as South Africa, Nigeria, Somalia, Kenya, Malawi, Ghana, Tanzania, Uganda and Zambia, this limited the generalizability of the findings and recommendations. Also, the other potential limitation is that using the inclusion-exclusion criteria could have resulted in bias when selecting the studies to include in the review. Practical implications The paper might serve as a valuable source of information for students, academics and entrepreneurs where the impact of interactive radio and SNSs on agriculture, education, health and governance, which are core determinants of development in Africa, has been assessed for further case studies in this area. Social implications The use of interactive radio has helped in decreasing health issues caused by a deficiency in vitamin A among children in sub-Saharan Africa. Originality/value The development of sustainable and effective interactive radio programs is dependent on the collaboration of the core stakeholders such as governmental ministries, donor organizations and the mass communication sector. Numerous open sources on technology radio stations are available to employ social media managers to help in the application of knowledge.
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Suri, Devika J., Jacob P. Tanumihardjo, Bryan M. Gannon, et al. "Serum retinol concentrations demonstrate high specificity after correcting for inflammation but questionable sensitivity compared with liver stores calculated from isotope dilution in determining vitamin A deficiency in Thai and Zambian children." American Journal of Clinical Nutrition 102, no. 5 (2015): 1259–65. http://dx.doi.org/10.3945/ajcn.115.113050.

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Gray, Brenda. "Vitamin Deficiency." Science News 159, no. 8 (2001): 115. http://dx.doi.org/10.2307/3981595.

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Kaliwile, Chisela, Charles Michelo, Jesse Sheftel, et al. "Breast Milk–Derived Retinol Is a Potential Surrogate for Serum in the 13C-Retinol Isotope Dilution Test in Zambian Lactating Women with Vitamin A Deficient and Adequate Status." Journal of Nutrition 151, no. 1 (2020): 255–63. http://dx.doi.org/10.1093/jn/nxaa320.

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ABSTRACT Background Vitamin A (VA) deficiency (VAD) affects ∼19 million pregnant women worldwide. The extent of VAD in Zambian women of reproductive age is unknown owing to lack of survey inclusion or the use of static serum retinol concentrations, a low-sensitivity biomarker. Objectives This cross-sectional study employed isotopic techniques to determine VA status with serum and milk among women aged 18–49 y (n = 197) either lactating with infants aged 0–24 mo or nonlactating with or without infants. Methods Assistants were trained and piloted data collection. Demographic data, anthropometry, and relevant histories were obtained including malaria and anemia. For retinol isotope dilution (RID), baseline fasting blood and casual breast milk samples were collected before administration of 2.0 μmol 13C2-retinyl acetate and 24-h dietary recalls. On day 14, blood (n = 144) and milk (n = 66) were collected. Prevalence of total liver VA reserves (TLR) ≤0.10 μmol/g was defined as VAD with comparison to the DRI assumption of 0.07 μmol/g as minimally acceptable for North Americans. Results When a 20% adjustment for dose lost to milk was made in the RID equation for lactation, mean total body VA stores (TBS) for lactating women were 25% lower than for nonlactating women (P &lt; 0.01), which was not the case without adjustment (P = 0.3). Mean ± SD TLR for all women were 0.15 ± 0.11 μmol/g liver. Using retinol purified from breast milk instead of serum for RID analysis yielded similar TBS and TLR, which were highly correlated between methods (P &lt; 0.0001). Serum retinol ≤0.70 μmol/L had 0% sensitivity using either VAD liver cutoff and milk retinol ≤1.0 μmol/L had 42% sensitivity for VAD at 0.10 μmol/g. Conclusions Determining accurate VA status among women of reproductive age, especially lactating women, forms a basis for extrapolation to the general population and informing policy development and program implementation.
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Dissertations / Theses on the topic "Vitamin A deficiency – Zambia"

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Sakala, Patricia. "Household consumption of orange - fleshed sweet potato and its associated factors in Chipata district, Eastern province, Zambia." University of the Western Cape, 2017. http://hdl.handle.net/11394/5644.

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Magister Scientiae (Nutrition Management) - MSc(NM)
Orange-fleshed sweet potato consumption promotion is one of the key nutrition sensitive interventions implementedto address high vitamin A deficiency among the rural population of Zambia since 2011. However, to date no study has been completed regarding household consumption of orange-fleshed sweet potato and factors related to their consumption. The study detailed here therefore sought to establish the consumption of orange-fleshed sweet potato, and to identify factors associated with its household consumption in the Integrating Orange Project areas in Chipata district of Zambia. The study randomly sampled 295 households, and collected information on the household characteristics, production, procurement, consumption and knowledge on orange-fleshed sweet potato. Cross tabulation chi square and one-way analysis of variance were used to identify associated consumption factors. The study found that 86.8% of the households ate orange-fleshed sweet potato; 49.5% ate it 1 to 3 days per week and 30.2% ate it at least 4 or more days per week, and only 13.2% did not consume orange-fleshed sweet potato at all. A relationship was found between having children younger than five years old and consumption of orange-fleshed sweet potato (P < 0.001). Results showed that 8.7% of households with children (n=183) never ate orange-fleshed sweet potato, versus 20.5% of households without children (n=112). Production of orange-fleshed sweet potato (n=178) was found to have a relationship with household conusmption of orange-fleshed sweet potato (P < 0.001). Only 1.1% of households that produced orange-fleshed sweet potato did not consume any, versus 31.6% who did not produce orange-fleshed sweet potato. Purchasing of orange-fleshed sweet potato (n=118) was found to have a relationship with its household consumption (P < 0.001); 56.2% of the households that ate orange-fleshed sweet potato 1 to 3 days during the previous week bought it, compared to only 27.0% of households who ate orange-fleshed sweet potato more than 4 days per week among those that bought it. The respondent‘s knowledge of the health benefits of orange-fleshed sweet potato was found to have a relationship with its consumption in the household (P < 0.001). Only 7.8% of the households where respondents knew the benefits of orange-fleshed sweet potato (n=215) never ate orange-fleshed potato, compared to 50.0% of households where the respondents did not know any benefit (n=80). In contrast, 33.5% of the households where the respondents knew the health benefits ate orange-fleshed sweet potato at least 4 days a week compared to only 7.9% of households where the respondents did not know any benefit. Overall, the study showed that most households consumed orange-fleshed sweet potato. The highconsumption might be due to seasonality, as the study was done during the harvesting season of orange-fleshed sweet potato. Also, prodcution of orange-fleshed sweet potato was promoted in the study area through the Integrating Orange Project. These results therefore suggest that projects seeking to promote consumption of orange-fleshed sweet potato as an intervention for vitamin A deficiency control should promote production of orange-fleshed sweet potato and sensitization of communities on the health benefits of orange-fleshed sweet potato consumption.
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Rashed, Ismail Ismail Ibrahim. "The association between vitamin D deficiency and tuberculosis : Effects of different levels of vitamin D deficiency - A meta-analysis." Thesis, Södertörns högskola, Institutionen för naturvetenskap, miljö och teknik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-38922.

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Aim: To conduct a systematic review and meta-analysis of all published studies studying the risk of vitamin D deficiency in tuberculosis patients and in healthy controls. Additionally, subgroup meta-analysis was performed based on the level of vitamin D to test the risk in TB groups and in healthy groups. Methods: Pubmed was searched for observational studies in human and English that discussed the association between risk of low serum vitamin D and TB. Meta-analysis was performed on all relevant studies combined and for subgroups of each vitamin D level. Results: 22 studies were selected and pooled in the analysis. The results were consistent with previous studies examining the same risk. The overall log risk ratio (log RR) of low vitamin D was significantly higher in TB patients 1.68 times than healthy controls. In 4 subgroup meta- analyses based on vitamin D level below (20 nmol/L, 30 nmol/L, 50 nmol/L, and 75 nmol/L), the risk of having low vitamin D in TB patients was (1.82, 2.89, 1.38, 1.32) respectively. That subgroup analysis showed more clearly the higher RR were below 20 and 30 nmol/L. The smallest RR was at 75 nmol/L level. Conclusion: This study verified the association between risk of low vitamin D level and TB development. It also clarified that, the risk increased by decreasing vitamin D level.
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Smith, Pamela Joy. "Vitamin D deficiency in three northern Manitoba communities." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0025/NQ51667.pdf.

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Barron, Mary Anne. "Vitamin K deficiency in paediatric bone marrow transplantation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0008/MQ40822.pdf.

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Zhang, Xueming. "Vitamin D receptor deficiency and postnatal tooth formation." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. http://www.mhsl.uab.edu/dt/2007m/zhang.pdf.

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Li, Ling, and 李玲. "Review of vitamin D deficiency among breast-feeding infants." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48424213.

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Background Vitamin D deficiency is prevalent in many places across the world. Breastfeeding has been suggested to be a significant predictor of vitamin D deficiency during infancy, which is preventable through proper supplementation. However, whether Hong Kong should adopt the international recommendation for supplementation of exclusive breastfed infants is still not yet answered. Objective: To review the available evidence regarding the association between breastfeeding and vitamin D deficiency during infancy, as well as the effectiveness of vitamin D supplementation of breastfed infants as an intervention measure. Methods A total of 5112 potentially relevant articles were searched and identified from MEDLINE (OVID, Pubmed), Science Citation Index Expanded (ISI Web of Science), Cochrane Central Register of Controlled Trials, EMBASE, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Chinese database (CNKI) without restriction from inception to July-06-2012. 5065 articles were excluded after the initial scanning of title and abstracts. 36 were subsequently excluded due to methodological issues. A total of 11 studies were included and reviewed by two independent reviewers. Results This review pooled together a total of 1126 exclusively breast-fed infants for less than one year old from 11 studies. The pooled average prevalence of vitamin D deficiency was 54.2%. The association between breastfeeding and vitamin D deficiency during infancy has been reported consistently, and it was found to be one of the strongest predictors of vitamin D deficiency for infants less than one year old. Sunlight exposure, season, and skin pigmentation were also found to be important affecting factors. Supplementation to breastfed infants with the dosages as recommended by American Academy of Pediatrics (AAP) seem to be effective in lifting up the vitamin D levels. Conclusions The Hong Kong Government and relevant health sectors should conduct local epidemiological study to investigate the problem of concern among our breast-fed infants, and seriously consider or evaluate the AAP recommendation of supplementation.
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Nolan, Maeve Roisin. "Studies of vitamin E and selenium deficiency in pigs." Thesis, Queen's University Belfast, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239214.

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Ahmed, Faruk. "The interaction of vitamin A deficiency and rotavirus infection." Thesis, University of Southampton, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327774.

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Mogusu, Eunice, Shimin Zheng, Sreenivas P. Veeranki, D. Kioko, and Megan Quinn. "Association of Vitamin D Deficiency with High Cholesterol Levels." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/104.

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Background Recent studies have demonstrated a significant relationship between vitamin D and cholesterol levels. Cholesterol is important in the synthesis and metabolism of vitamin D. Additionally, foods rich in vitamin D also contain high cholesterol supplements. Given that sources of vitamin D and cholesterol are different, we hypothesized that there is a potential mean bias in true relationship between an individual’s vitamin D and cholesterol levels. The study therefore aimed to examine the relationship of serum cholesterol and vitamin D levels. Methods We utilized NHANES 2001-2006 data (n=30,954). The outcome was vitamin D deficiency defined as individuals with serum 25-hydroxyvitamin D level12 ng/ml were classified as normal. Significant differences in cholesterol levels between the two groups were determined using Chi-Square contingency test. Generalized linear models were conducted to assess the association of vitamin D deficiency with cholesterol levels adjusting for age, sex, physical activity (proxy measure for sunlight exposure) and other serum lipid levels. Results Vitamin D deficiency was significantly lower in males(5.2%) than females(7.8%)(P Conclusion Vitamin D deficiency was associated with high LDL and triglyceride levels. Study findings help establish the importance of distinguishing vitamin D and cholesterol levels as separate entities while making inferences about their relationship with chronic diseases.
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Vedantam, Venkata Sri Harsha, Neethu Nair, CHRISTINE MOORE, and Diana Gorman-Nunley. "VITAMIN B12 DEFICIENCY ANEMIA-ASSOCIATED MALIGNANCY ACCELERATED BY SUPPLEMENTATION." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/49.

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Vitamin B12 and folate are necessary for bone marrow progenitor growth and division. Deficiencies are common in lymphoproliferative disorders due to increased demands of rapidly growing malignant cells. Isolated vitamin B12 deficiency is seen in 13% of these patients and may be their only manifestation. We present the case of vitamin B12 deficiency anemia due to an underlying malignancy that was discovered following supplementation. A 77-year-old nonsmoker female with chronic kidney disease and hypothyroidism presented to her internist with dyspnea, tachycardia and unintentional 7-pound weight loss. Age-appropriate cancer screenings were up-to-date. Physical exam was notable for an overweight female with tachycardia and trace ankle edema bilaterally. Electrocardiogram demonstrated sinus tachycardia. Labs were remarkable for hemoglobin 10.3 mg/dL (12.1 mg/dL one year ago) and serum B12/mL. She was started on intramuscular vitamin B12 supplementation. At her one-month follow-up, she reported debilitating gastrointestinal distress, rash, and fatigue lasting 5-6 days with every vitamin B12 injection. Physical exam was notable for 20-pound weight loss. Labs revealed hemoglobin 9.9 mg/dL despite serum B12 750 pg/mL and worsening kidney function with marked proteinuria. Additional work-up by primary team and subsequent Hematology & Oncology referral demonstrated elevated M-spike on urine protein electrophoresis and abnormal bone marrow biopsy suspicious for lymphoid malignancy. CT abdomen and whole body PET scan revealed increased uptake in the T12 vertebrae and multiple nodal basins consistent with stage IV lymphoma. Biopsy of vertebral body confirmed diffuse large B-cell lymphoma. The patient received one cycle of chemotherapy with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone). Her course was complicated by pathologic hip fracture requiring hospitalization and surgical repair. The patient died following cardiac arrest in the setting of septic shock from sigmoid colon perforation 7 months from initial presentation. Vitamin B12 and folate play critical roles in nucleic acid synthesis for bone marrow progenitors. Vitamin B12 deficiency arrests cell growth and division, leading to macrocytic anemia and various neuropsychiatric manifestations. It is a common diagnosis with numerous causes: autoantibodies to digestive proteins, poor dietary intake, small bowel malabsorption, etc. Diagnose with low hemoglobin (/dL or 13 mg/dL in non-pregnant women or men, respectively) and mean corpuscular volume >100 fL plus low serum B12 or elevated homocysteine and methyl-malonic acid levels. Replacement is given orally or intramuscularly. Vitamin B12 and folate deficiencies are found in lymphoproliferative disorders due to increased demands of rapidly growing malignant cells. Isolated vitamin B12 deficiency is seen in 13% of patients and may be the only clue. Replacement will not resolve their anemia. Physicians should monitor patients receiving supplementation. If anemia fails to improve or patients experience systemic symptoms, further investigation for lymphoid malignancies is warranted. This patient had dramatic deterioration with acceleration of underlying malignancy following vitamin B12 replacement. We believe supplementation enabled malignant lymphoid precursors to resume cell cycle growth and division. Only one report of vitamin B12 supplementation associated with unmasking a lymphoid malignancy exists in literature. Further research is needed to support whether supplementation can accelerate lymphoid malignancies.
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Books on the topic "Vitamin A deficiency – Zambia"

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Kafwembe, Emmanuel M. Vitamin 'A' baseline survey, Zambia: Final laboratory report (October 1997-March 1998). Tropical Diseases Research Centre, 1997.

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East, Central, and Southern African Regional Workshop on Vitamin A Interventions and Child Survival (1990 Lusaka, Zambia). East, Central, and Southern African Regional Workshop on Vitamin A Interventions and Child Survival, Lusaka, Zambia, 21-24 June 1990: Proceedings. Vitamin A Technical Assistance Program, Helen Keller International, 1990.

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Houston, Robin. Strengthening monitoring systems for vitamin A programs in Zambia, with a focus on fortification: Trip report, June 10-17, 2001. s.n., 2001.

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Clemetson, C. Alan B. Vitamin C. CRC Press, 1989.

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Clemetson, C. Alan B. Vitamin C. CRC Press, 1989.

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Clemetson, C. Alan B. Vitamin C. CRC Press, 1989.

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Clemetson, C. Alan B. Vitamin C. CRC Press, 1989.

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Clemetson, C. Alan B. Vitamin C. CRC Press, 1989.

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National Workshop on "Combating Vitamin A Deficiency through Dietary Improvement (1992 New Delhi, India). Combating vitamin A deficiency through dietary improvement. Nutrition Foundation of India, 1992.

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P, West Keith, ed. Vitamin A deficiency: Health, survival, and vision. Oxford University Press, 1996.

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Book chapters on the topic "Vitamin A deficiency – Zambia"

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Laskaris, George, and Crispian Scully. "Vitamin Deficiency." In Periodontal Manifestations of Local and Systemic Diseases. Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-642-55596-1_28.

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Serratrice, Jacques. "Vitamin Deficiency." In International Neurology. Wiley-Blackwell, 2010. http://dx.doi.org/10.1002/9781444317008.ch107.

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Davila, Jennifer, and Maria C. Velez-Yanguas. "Vitamin B12 Deficiency." In Hematology in the Adolescent Female. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-48446-0_18.

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McKenna, Malachi J., and Barbara Murray. "Vitamin D Deficiency." In Endocrinology and Diabetes. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8684-8_23.

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Balemans, Wendy, Wim Van Hul, Marian Valko, et al. "Vitamin B12 Deficiency." In Encyclopedia of Molecular Mechanisms of Disease. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_8166.

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Balemans, Wendy, Wim Van Hul, Marian Valko, et al. "Vitamin A Deficiency." In Encyclopedia of Molecular Mechanisms of Disease. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_1852.

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Balemans, Wendy, Wim Van Hul, Marian Valko, et al. "Vitamin C Deficiency." In Encyclopedia of Molecular Mechanisms of Disease. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_1854.

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Balemans, Wendy, Wim Van Hul, Marian Valko, et al. "Vitamin D Deficiency." In Encyclopedia of Molecular Mechanisms of Disease. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_1855.

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Balemans, Wendy, Wim Van Hul, Marian Valko, et al. "Vitamin E Deficiency." In Encyclopedia of Molecular Mechanisms of Disease. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_1856.

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Balemans, Wendy, Wim Van Hul, Marian Valko, et al. "Vitamin K Deficiency." In Encyclopedia of Molecular Mechanisms of Disease. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_1858.

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Conference papers on the topic "Vitamin A deficiency – Zambia"

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Omotosho, Oluyinka, Yetunde Akinwale, and Adedoyin Idris. "Semantic Based Vitamin Deficiency Monitoring System." In ICSCA 2020: 2020 9th International Conference on Software and Computer Applications. ACM, 2020. http://dx.doi.org/10.1145/3384544.3384598.

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Bellocchia, Michela, Monica Boita, Filippo Patrucco, et al. "Vitamin D deficiency and COPD exacerbations: Effect of vitamin D supplementation." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa3961.

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Kumar, Toshita, Ali Sadoughi, Nina Kohn, Rebecca Miller, Twinkle Chandak, and Arunabh Talwar. "Vitamin D Deficiency In Advanced Lung Disease." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2346.

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Filipovic, Snezana, Vucinic Violeta, Videnovic Jelica, Stjepanovic Mihailo, and Jandric Aleksandar. "Vitamin D deficiency and activity of sarcoidosis." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa827.

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Quiles, K., F. Z. Shao, E. Johnson, and F. Chen. "Vitamin A Deficiency and the Lung Microbiome." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7442.

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Koldobskiy, Dafna, Giora Netzer, Sachin Patel, and Avelino Verceles. "Vitamin D Deficiency In Chronically Ventilated Patients." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3094.

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De La Zerda, David J., Zach Reagle, Hani El Jammal, Ivo Dinov, Sunnet Bekal, and Michael W. Peterson. "Role Of Vitamin D Deficiency In Sepsis Outcome." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5606.

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Quwatli, Zakwan, Rashid Nadeem, Janos Molnar, Adeel Rishi, and Ahmet Copur. "Does Vitamin D Deficiency Affect Obstructive Sleep Apnea?" In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5262.

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Cavalcante Neto, P. M., N. de Castro Carvalho, D. de Sá Pereira Belfort, et al. "Pulmonary Hypertension and Vitamin C Deficiency - Case Report." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a3600.

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Al Hamad Al Khamis Al Mubarak, Hanadi, Navas Nadukkandiyil, Essa Al Mubarak Al Sulaiti, Ayman El-menyar, and Anoop Sankaranarayanan. "Vitamin D Deficiency Among The Elderly: Insights From Qatar." In Qatar Foundation Annual Research Conference Proceedings. Hamad bin Khalifa University Press (HBKU Press), 2014. http://dx.doi.org/10.5339/qfarc.2014.hbpp0808.

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Reports on the topic "Vitamin A deficiency – Zambia"

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Shi, Shanzhen, Jiaxing Feng, Yu Li, and Huaxiu Shi. Risk factors for vitamin D deficiency in inflammatory bowel disease: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2020. http://dx.doi.org/10.37766/inplasy2020.6.0028.

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Laird, Eamon, and Rose Anne Kenny. Vitamin D deficiency in Ireland – implications for COVID-19. Results from the Irish Longitudinal Study on Ageing (TILDA). The Irish Longitudinal Study on Ageing, 2020. http://dx.doi.org/10.38018/tildare.2020-05.

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Treating vitamin D deficiency may reduce exacerbations of COPD. National Institute for Health Research, 2019. http://dx.doi.org/10.3310/signal-000737.

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