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1

Institute of Medicine. Committee on International Nutrition--Vitamin C in Food Aid Commodities. Vitamin C fortification of food aid commodities: Final report. Washington, D.C: National Academy Press, 1997.

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2

Tay, Chiok Liang. Triple fortification of salt with iodine, iron and vitamin A. Ottawa: National Library of Canada, 2002.

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3

Raileanu, Ildiko. Triple fortification of salt with iodine, iron, and vitamin A. Ottawa: National Library of Canada, 2002.

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4

Lotfi, Mahshid. Food fortification in Canada: Experiences and issues in controlling micronutrient malnutrition. Ottawa: International Development Research Centre, 2001.

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5

Houston, Robin. Strengthening monitoring systems for vitamin A programs in Zambia, with a focus on fortification: Trip report, June 10-17, 2001. [Lusaka: s.n., 2001.

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6

Manila Forum 2000: Strategies to fortify essential foods in Asia and the Pacific : proceedings of a Forum on Food Fortification Policy for Protecting Populations in Asia and the Pacific from Mineral and Vitamin Deficiencies, Asian Development Bank, Manila, Philippines, 21-24 February 2000. Manila, Philippines: Asian Development Bank, 2000.

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7

Vitamin C Fortification of Food Aid Commodities. Washington, D.C.: National Academies Press, 1997. http://dx.doi.org/10.17226/6009.

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8

Benkeblia, Noureddine. Vitamin and Mineral Bio-Fortification of Edible Plants. Wiley & Sons, Limited, John, 2020.

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9

Vitamin C Fortification of Food Aid Commodities: Final Report. National Academies Press, 1998.

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10

Food Fortification: The Evidence, Ethics, and Politics of Adding Nutrients to Food. Oxford University Press, 2013.

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11

Initiative, Micronutrient. Sugar Fortification to End Vitamin a Deficiency in Southern and Eastern Africa: Report of a Public-Private Dialogue (Micronutrient Initiative Series). Intl Development Research, 1999.

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12

Jadon, Deepak R., Tehseen Ahmed, and Ashok K. Bhalla. Disorders of bone mineralization—osteomalacia. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199642489.003.0146_update_001.

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Disorders of bone mineralization cause rickets in children and osteomalacia in adults. Both remain common in developing countries. Incidence in Western countries had declined since the fortification of foodstuffs, but appears to be increasing again. Calcium and inorganic phosphate are the key precursors for bone mineralization and growth. The commonest aetiology of osteomalacia is vitamin D deficiency, primarily due to low dietary intake and inadequate sun exposure. In the last decade gene mutations have been identified that are responsible for inherited rickets and osteomalacia, particularly those that result in phosphate deficiency, hypophosphatasia, and vitamin D receptor or metabolizing enzyme mutations. Additionally, the pathogenesis of tumour-induced osteomalacia is becoming better understood. Osteomalacia may present as bone pain and tenderness, muscle pain and weakness, and skeletal deformity or fracture. Key investigations include biochemical assessment and plain radiographs. Radioisotope bone scans and bone biopsy may be considered in selected cases. Differential diagnoses include osteoporosis, seronegative arthritides, and localized soft tissue disorders. Treatment, guided by the underlying aetiology, aims to reduce symptoms, fracture risk, bone deformity and sequelae. Vitamin D deficient patients require vitamin D and calcium replacement.
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13

Jadon, Deepak R., Tehseen Ahmed, and Ashok K. Bhalla. Disorders of bone mineralization—osteomalacia. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0146.

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Disorders of bone mineralization cause rickets in children and osteomalacia in adults. Both remain common in developing countries. Incidence in Western countries had declined since the fortification of foodstuffs, but appears to be increasing again. Calcium and inorganic phosphate are the key precursors for bone mineralization and growth. The commonest aetiology of osteomalacia is vitamin D deficiency, primarily due to low dietary intake and inadequate sun exposure. In the last decade gene mutations have been identified that are responsible for inherited rickets and osteomalacia, particularly those that result in phosphate deficiency, hypophosphatasia, and vitamin D receptor or metabolizing enzyme mutations. Additionally, the pathogenesis of tumour-induced osteomalacia is becoming better understood. Osteomalacia may present as bone pain and tenderness, muscle pain and weakness, and skeletal deformity or fracture. Key investigations include biochemical assessment and plain radiographs. Radioisotope bone scans and bone biopsy may be considered in selected cases. Differential diagnoses include osteoporosis, seronegative arthritides, and localized soft tissue disorders. Treatment, guided by the underlying aetiology, aims to reduce symptoms, fracture risk, bone deformity and sequelae. Vitamin D deficient patients require vitamin D and calcium replacement.
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14

HMSO. Fortification of Yellow Fats with Vitamins A & D, (Report on Health & Social Subjects). Bernan Press, 1991.

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15

Stein, Alexander J. The Poor, Malnutrition, Biofortification, and Biotechnology. Edited by Ronald J. Herring. Oxford University Press, 2013. http://dx.doi.org/10.1093/oxfordhb/9780195397772.013.005.

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While less apparent than outright hunger or obesity, the lack of essential vitamins and minerals in people’s diets is one of the leading contributors to the global burden of disease. Current interventions, such as supplementation or fortification, are being implemented with varying success, but—while important—overall progress in the fight against micronutrient malnutrition has been limited. Biofortification, the breeding of crops for higher contents of vitamins and minerals, is a new approach to complement existing interventions. This chapter gives an overview of the problem of micronutrient malnutrition and how it is measured; it briefly discusses current micronutrient interventions, and then presents the reasoning behind biofortification before it examines the feasibility of biofortifying crops and summarizes studies on their potential impact and economic justification. After listing current biofortification programs, the chapter looks into the political controversy surrounding genetic engineering in agriculture and how it relates to biofortification; it then concludes with an assessment of the current status of biofortification and its potential.
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