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Journal articles on the topic 'Vitamin A Therapeutic use Tanzania'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 January 2023

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1

Kisamo, Ombeni, Manase Kilonzi, Wigilya P. Mikomangwa, George M. Bwire, Hamu J. Mlyuka, Alphonce I. Marealle, and Ritah F. Mutagonda. "The magnitude of prescribing medicines by brand names at Muhimbili National Hospital, Tanzania." Medicine Access @ Point of Care 4 (January 2020): 239920261990014. http://dx.doi.org/10.1177/2399202619900148.

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Background: Tanzania National Treatment Guidelines and National Therapeutic Committee circular of 2012 requires prescribers to prescribe medicines using their generic names as recommended by the World Health Organization. The implementation of the aforementioned recommendations by prescribers is not well documented in our settings. Therefore, this study aimed to explore the compliance on the use of generic names by prescribers at Muhimbili National Hospital. Methods: A descriptive cross-sectional study was conducted at Muhimbili National Hospital from January to May 2019 in both inpatient and

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Mwita, Julius Chacha, Albertino Damasceno, Pilly Chillo, Okechukwu S. Ogah, Karen Cohen, Anthony Oyekunle, Endale Tefera, and Joel Msafiri Francis. "Vitamin K-dependent anticoagulant use and level of anticoagulation control in sub-Saharan Africa: protocol for a retrospective cohort study." BMJ Open 12, no. 2 (February 2022): e057166. http://dx.doi.org/10.1136/bmjopen-2021-057166.

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BackgroundGiven that vitamin K-dependent anticoagulants (VKAs) will continue to be the primary anticoagulant in Africa for a long time, understanding the quality of anticoagulation services in the continent is vital for optimising the intended benefits. Notably, a few small studies have assessed the quality of anticoagulation in sub-Saharan Africa (SSA) countries. This study will describe the current VKA use and anticoagulation control among patients in selected SSA countries.Methods and analysisWe plan to review the 2019 anticoagulation data of a cohort of 800 random patients from 19 selected

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Haile, Zelalem T., Asli K. Teweldeberhan, Bhakti Chavan, and John Francescon. "Hormonal contraceptive use and vitamin A deficiency among women in Tanzania." International Journal of Gynecology & Obstetrics 141, no. 1 (December 15, 2017): 20–25. http://dx.doi.org/10.1002/ijgo.12396.

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M. Fletcher, Jean, Sharee A. Basdeo, Aideen C. Allen, and Padraic J. Dunne. "Therapeutic Use of Vitamin D and its Analogues in Autoimmunity." Recent Patents on Inflammation & Allergy Drug Discovery 6, no. 1 (January 1, 2012): 22–34. http://dx.doi.org/10.2174/187221312798889239.

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Zbinden, Gerhard. "THERAPEUTIC USE OF VITAMIN B1 IN DISEASES OTHER THAN BERIBERI." Annals of the New York Academy of Sciences 98, no. 2 (December 15, 2006): 550–61. http://dx.doi.org/10.1111/j.1749-6632.1962.tb30576.x.

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Carazo, Alejandro, Kateřina Macáková, Kateřina Matoušová, Lenka Kujovská Krčmová, Michele Protti, and Přemysl Mladěnka. "Vitamin A Update: Forms, Sources, Kinetics, Detection, Function, Deficiency, Therapeutic Use and Toxicity." Nutrients 13, no. 5 (May 18, 2021): 1703. http://dx.doi.org/10.3390/nu13051703.

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Vitamin A is a group of vital micronutrients widely present in the human diet. Animal-based products are a rich source of the retinyl ester form of the vitamin, while vegetables and fruits contain carotenoids, most of which are provitamin A. Vitamin A plays a key role in the correct functioning of multiple physiological functions. The human organism can metabolize natural forms of vitamin A and provitamin A into biologically active forms (retinol, retinal, retinoic acid), which interact with multiple molecular targets, including nuclear receptors, opsin in the retina and, according to the late

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Donaldson, CJ, and DJ Harrington. "Therapeutic warfarin use and the extrahepatic functions of vitamin K-dependent proteins." British Journal of Biomedical Science 74, no. 4 (June 28, 2017): 163–69. http://dx.doi.org/10.1080/09674845.2017.1336854.

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Thabet, Romany H., Adel A. Gomaa, Laila M. Matalqah, and Erin M. Shalaby. "Vitamin D: an essential adjuvant therapeutic agent in breast cancer." Journal of International Medical Research 50, no. 7 (July 2022): 030006052211138. http://dx.doi.org/10.1177/03000605221113800.

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Low serum levels of vitamin D have been reported as a risk factor for breast cancer. This narrative review provides an update on the impact of vitamin D on hormone receptors, notably estrogen receptor subunits, and gives insights on possible therapeutic interventions to overcome breast cancer. In addition, evidence that supports the beneficial use of vitamin D as adjuvant treatment of breast cancer is summarized. Vitamin D deficiency is significantly widespread in patients with triple-negative tumors. Several studies have observed a possible modulatory effect of vitamin D or its analogues on t

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Ræder, Helge, Nick Shaw, Coen Netelenbos, and Robert Bjerknes. "A case of X-linked hypophosphatemic rickets: complications and the therapeutic use of cinacalcet." European Journal of Endocrinology 159, suppl_1 (December 2008): S101—S105. http://dx.doi.org/10.1530/eje-08-0383.

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In hypophosphatemic rickets, there are both inherited and acquired forms, where X-linked dominant hypophosphatemic rickets (XLH) is the most prevalent genetic form and caused by mutations in the phosphate-regulating endopeptidase (PHEX) gene. XLH is associated with growth retardation and bone deformities. The renal tubular cells have an important role in calcium and phosphate metabolism, where the 1α-hydroxylase enzyme metabolizes the conversion of 25 (OH)-vitamin D to potent 1,25 (OH)2-vitamin D, whereas the sodium–phosphate transporter controls tubular phosphate reabsorption. The pathophysio

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Kurushina, O. V., A. E. Barulin, and O. I. Agarkova. "Use of parenteral vitamin B complexes in treatment of polyneuropathy." Medical Council, no. 18 (November 17, 2018): 62–66. http://dx.doi.org/10.21518/2079-701x-2018-18-62-66.

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The article considers the ethiological factors for the formation of such a widespread disease of the peripheral nervous system as polyneuropathy. The classification, modern approaches to the diagnosis of various types of diseases are presented. The authors emphasize on the therapeutic approaches to the treatment of such common forms as diabetic and alcoholic polyneuropathies. Particular attention is paid to the complex of B vitamins. The effectiveness and safety of the injectable form of vitamins for the therapy of polyneuropathies are demonstrated.

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Nalyotov, Andrew V., Tatjana I. Shapchenko, and Dmitrij I. Masjuta. "The efficiency of vitamin D using in the formation of food tolerance to cow’s milk protein in children with food allergy." Pediatrician (St. Petersburg) 10, no. 4 (December 5, 2019): 25–29. http://dx.doi.org/10.17816/ped10425-29.

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The problem of vitamin D deficiency is one of the most actual today, because, according to the results of numerous studies, its deficiency is registered in half the worlds population. The article presents the results of a study on the level of vitamin D in children of first year of life, suffering from cows milk proteins allergy, as well as in children who have formed a secondary food tolerance to this allergen. In the article was evaluated the effectiveness of the additional use of vitamin D against the background of the therapeutic dairy-free diet use. It was found that the 57.1 4.8% childre

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Banks, Mindy, and Stuart M. Sprague. "Vitamin D and Peritoneal Dialysis." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 28, no. 2_suppl (March 2008): 33–37. http://dx.doi.org/10.1177/089686080802802s06.

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Chronic kidney disease – mineral and bone disorder (CKD–MBD) is a cause of significant morbidity and mortality in patients with long-standing kidney disease. Management of secondary hyperparathyroidism includes the use of phosphorus-binding agents and treatment with activated vitamin D compounds, better referred to as vitamin D receptor agonists (VDRAs). In an effort to maximize the therapeutic response while reducing the adverse effects of calcitriol, the naturally synthesized hormone, the use of intravenous administration and several selective VDRAs have been developed. Recently, oral prepar

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Brossaud, J., V. Pallet, and J.-B. Corcuff. "Vitamin A, endocrine tissues and hormones: interplay and interactions." Endocrine Connections 6, no. 7 (October 2017): R121—R130. http://dx.doi.org/10.1530/ec-17-0101.

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Vitamin A (retinol) is a micronutrient critical for cell proliferation and differentiation. In adults, vitamin A and metabolites such as retinoic acid (RA) play major roles in vision, immune and brain functions and tissue remodelling and metabolism. This review presents the physiological interactions of retinoids and endocrine tissues and hormonal systems. Two endocrine systems have been particularly studied. In the pituitary, retinoids target the corticotrophs with a possible therapeutic use in corticotropinomas. In the thyroid, retinoids interfere with iodine metabolism and vitamin A deficie

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Azevedo, Fernanda Reis de, and Bruno Caramelli. "Hypovitaminosis D and Obesity—Coincidence or Consequence?" US Endocrinology 09, no. 01 (2013): 40. http://dx.doi.org/10.17925/use.2013.09.01.40.

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Vitamin D has attracted much scientific interest in recent years, mostly due to its newly described roles in metabolism regulation and cell proliferation. Along with hypovitaminosis D, the incidence of obesity has risen and has become a public health concern. The association between these two conditions is not merely coincidence and is being deeply investigated regarding its prevalence, mechanism, and even a possible causal relation. The data are still inconclusive but there is important evidence indicating that vitamin D is involved with fat accumulation, the responsible mechanism however sti

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Richard, Seidu A., Marian Sackey, and Nii Korley Kortei. "Exploring the Pivotal Neurophysiologic and Therapeutic Potentials of Vitamin C in Glioma." Journal of Oncology 2021 (December 14, 2021): 1–12. http://dx.doi.org/10.1155/2021/6141591.

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Gliomas represent solely primary brain cancers of glial cell or neuroepithelial origin. Gliomas are still the most lethal human cancers despite modern innovations in both diagnostic techniques as well as therapeutic regimes. Gliomas have the lowest overall survival rate compared to other cancers 5 years after definitive diagnosis. The dietary intake of vitamin C has protective effect on glioma risk. Vitamin C is an essential compound that plays a vital role in the regulation of lysyl and prolyl hydroxylase activity. Neurons store high levels of vitamin C via sodium dependent-vitamin C transpor

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Noor, Ramadhani A., Ajibola I. Abioye, Anne Marie Darling, Ellen Hertzmark, Said Aboud, Zulfiqarali Premji, Ferdinand M. Mugusi, et al. "Prenatal Zinc and Vitamin A Reduce the Benefit of Iron on Maternal Hematologic and Micronutrient Status at Delivery in Tanzania." Journal of Nutrition 150, no. 2 (October 16, 2019): 240–48. http://dx.doi.org/10.1093/jn/nxz242.

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ABSTRACT Background Zinc and vitamin A supplementation have both been shown to affect iron status, hemoglobin (Hb) concentration, and anemia in animal and human studies. However, evidence on their combined use in pregnancy, in the context of iron–folic acid (IFA) supplementation, remains limited. Objective This study determined the effects of prenatal zinc, vitamin A, and iron supplementation on maternal hematologic and micronutrient status at delivery in Tanzania. Methods We analyzed 2 large randomized controlled trials, using generalized estimating equations, and examined the effect of daily

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Vorobyova, М. Р., and E. Р. Karpova. "Use of vitamin D to prevent recurrent otitis media in children." Medical Council, no. 2 (February 16, 2019): 259–63. http://dx.doi.org/10.21518/2079-701x-2019-2-259-263.

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This article addresses the problem of recurrent otitis media (ROM) in children. The study was aimed to increase the clinical efficacy of prophylactic treatment of ROM in children. The study showed that the children diagnosed with ROM had significantly lower serum 25(OH) vitamin D levels as compared to the healthy children. The follow-up observation and treatment of children with ROM allowed for the conclusion that all children at risk of ROM required the systemic examination of serum 25(OH) vitamin D and further therapeutic and prophylactic management.

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Perumpail, Brandon, Andrew Li, Nimy John, Sandy Sallam, Neha Shah, Waiyee Kwong, George Cholankeril, Donghee Kim, and Aijaz Ahmed. "The Role of Vitamin E in the Treatment of NAFLD." Diseases 6, no. 4 (September 24, 2018): 86. http://dx.doi.org/10.3390/diseases6040086.

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There has been a growing interest in the role of vitamin E supplementation in the treatment and/or prevention of nonalcoholic fatty liver (NAFLD). We performed a systematic review of the medical literature from inception through 15 June 2018 by utilizing PubMed and searching for key terms such as NAFLD, vitamin E, alpha-tocopherol, and nonalcoholic steatohepatitis (NASH). Data from studies and medical literature focusing on the role of vitamin E therapy in patients with NAFLD and nonalcoholic steatohepatitis (NASH) were reviewed. Most studies assessing the impact of vitamin E in NAFLD were des

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Latham, Michael C., Deborah M. Ash, Diklar Makola, Simon R. Tatala, Godwin D. Ndossi, and Haile Mehansho. "Efficacy Trials of a Micronutrient Dietary Supplement in Schoolchildren and Pregnant Women in Tanzania." Food and Nutrition Bulletin 24, no. 4_suppl_1 (January 2003): S120—S128. http://dx.doi.org/10.1177/15648265030244s109.

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Traditionally, the main strategies used to control micronutrient deficiencies have been food diversification, consumption of medicinal supplements, and food fortification. In Tanzania, we conducted efficacy trials using a dietary supplement as a fourth approach. These were randomized, double-blind, placebo-controlled efficacy trials conducted separately first in children and later in pregnant women. The dietary supplement was a powder used to prepare an orange-flavored beverage. In the school trial, children consumed 25 g per school day attended. In the pregnancy trial, women consumed the cont

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Налетов, А. В., Т. И. Шапченко та И. В. Коктышев. "ЭФФЕКТИВНОСТЬ ИСПОЛЬЗОВАНИЯ ВИТАМИНА D В ЛЕЧЕНИИ ДЕТЕЙ С АЛЛЕРГИЕЙ К БЕЛКАМ КОРОВЬЕГО МОЛОКА". Университетская клиника, № 3(32) (1 жовтня 2019): 40. http://dx.doi.org/10.26435/uc.v0i3(32).340.

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The article presents the results of a study on the level of vitamin D in children of first year with cow's milk proteins allergy. The aim of the work is to evaluate the effectiveness of using an aqueous solution of vitamin D in addition to a therapeutic elimination diet in children who are allergic to cow's milk proteins. It was found that the 57.1±4.8 % children of first year with cow's milk proteins allergy have vitamin D insufficiency. Normal vitamin D levels were found in only 36.2±4.7 % % patients. In turn, vitamin D deficiency were found in 6,7±2,4 % children. The additional intake of vi

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Pestova, V. Yu. "Alfacalcidol use in complex therapy of atopic dermatitis." Kazan medical journal 96, no. 6 (December 15, 2015): 952–58. http://dx.doi.org/10.17750/kmj2015-952.

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Aim. To study clinical course of atopic dermatitis and improve dermatosis therapeutic tactics in vitamin D deficiency. Study design - comparative observational open-label study. Methods. 67 patients with a verified «atopic dermatitis» diagnosis were selected to study. Serum calcidol level below 75 nmol/l was observed in 32 patients what was the basis to division of the observed patients into two groups. Conventional therapy (local glucocorticoids and moistening agents, systemic administration of non-specific anti-inflammatory and desensitizing agents) was administered to all patients. Vi

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Locantore-Ford, Patricia, Ronak Mistry, Evani Patel, Sarah Chen, and Robert C. Goodacre. "Use of an Antifibrinolytic Agent and Vitamin K As Alternative to Platelet Transfusions in Autologous Hematopoietic Cell Transplantation." Blood 138, Supplement 1 (November 5, 2021): 2916. http://dx.doi.org/10.1182/blood-2021-149823.

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Abstract Background Managing thrombocytopenia with a prophylactic strategy was previously recommended for patients with impaired bone marrow function, hematological malignancies, and recipients of HCT when platelet counts declined to under 10,000/uL. However, the updated 2018 ASCO guidelines now suggest a place for a therapeutic i.e., after a bleeding event rather than a prophylactic platelet transfusion strategy for patients with hematologic malignancies undergoing autologous HCT. Studies show a lack of significant difference between trial groups in hemostatic outcomes, such as the number of

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Javorski, Michael J., Mina M. Kerolos, Jawed Fareed, and R. Anthony Perez-Tamayo. "Vitamin D and Postoperative Vasopressor Use in Cardiopulmonary Bypass." Clinical and Applied Thrombosis/Hemostasis 24, no. 8 (May 6, 2018): 1322–26. http://dx.doi.org/10.1177/1076029618772357.

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The use of cardiopulmonary bypass (CPB) in cardiac surgery often leads to a systemic inflammatory response. Up to 25% of patients undergoing CPB for cardiac surgery are reported to develop vasoplegic syndrome in the acute postoperative period, in which the patients are refractory to vasopressors. The purpose of this study is to assess vitamin D deficiency as a risk factor for vasoplegia after using CPB. We performed a retrospective review of 1322 patients undergoing adult cardiac surgery requiring CPB. Forty-six patients with previously recorded 25-hydroxy vitamin D (25(OH)D) levels within 6 m

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Moustiés, Célia, Claire Bourlieu-Lacanal, Youna M. Hemery, Bruno Baréa, Pierre Villeneuve, Adrien Servent, Pascaline Alter, et al. "Nutritional quality of Ready-to-Use Therapeutic Foods: focus on lipid composition and vitamin content." OCL 29 (2022): 13. http://dx.doi.org/10.1051/ocl/2022007.

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Severe Acute Malnutrition (SAM) is still a public health issue in many low-income and middle-income countries. Its management has changed with the development of Ready-to-Use Therapeutic Foods (RUTF) that are energy-dense, lipid-based, micronutrient-enriched foods. The purpose of the present study was to define some aspects of the nutritional profile (in particular, lipid content, fatty acids profile, lipophilic vitamin content), oxidative status, and mycotoxin content of three RUTF products (of which two manufactured in Asia and one in Europe), at different time points during their storage. A

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Badawy, Ingy, Mahmoud Mohsen, Alaa Ahmed, Shrouk Mahmoud, Amany Saeed, Amr Atef, AlTaher Rabea, Marina Mauric, and Baher Zlat. "NOVEL THERAPEUTIC USE OF INSULIN AND VITAMIN E IN (NAFLD) USING FATTY LIVER INDUCED RATS." International Journal of Advanced Research 6, no. 5 (May 31, 2018): 927–31. http://dx.doi.org/10.21474/ijar01/7113.

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Dias, Bina F., and Aparna Dilip Nimkar. "Effect of medical nutrition therapy on vitamin C and malondialdehyde in HIV positive malnourished children." International Journal of Research in Medical Sciences 5, no. 11 (October 27, 2017): 4822. http://dx.doi.org/10.18203/2320-6012.ijrms20174927.

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Background: The objective is to assess the effect of medical nutrition therapy on biochemical parameters like Vitamin C and Malondialdehyde by estimating oxidative stress in HIV positive malnourished childrens’ sample. Any alteration in the antioxidant markers can help to assess the effectiveness of MNT as a therapeutic agent. There is limited data on the use of Ready to Use Therapeutic Food (RUTF) in India. Therefore, the study was conducted to determine the effect of prepared Ready to Use Therapeutic Food (RUTF) also termed as Medical Nutrition Therapy (MNT) in HIV positive malnourished chil

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Grant, Frederick, Robert Ackatia-Armah, Haile Okuku, and Rogers Kakuhenzire. "Association Between Nutrition Social Behavior Change Communication and Improved Caregiver Health and Nutrition Knowledge, Attitudes and Practices in Rural Tanzania." Current Developments in Nutrition 4, Supplement_2 (May 29, 2020): 193. http://dx.doi.org/10.1093/cdn/nzaa043_044.

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Abstract Objectives Efforts to improve infant and young child (IYC) feeding practices include the use of nutrition social behaviour change communication (SBCC) among caregivers of children under 5y. We assessed the association between monthly participation in community-level nutrition group meetings on caregiver health and nutrition knowledge, attitudes and practices (KAPs). Methods Data from community-based cross-sectional survey conducted in Eastern and Southern Highland Zones of Tanzania, were used. Indices were developed for caregivers’ knowledge on nutrition, health-and-childcare, househo

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Begum, Sartaz, Derick R. Mwakimbwala, Gideon Sangiwa, and Valence M. K. Ndesendo. "Chemical Analysis, Antibacterial Activities and Uses of Leaves and Calyces of Hibiscus sabdariffa Grown in Dodoma, Tanzania." Tanzania Journal of Science 48, no. 4 (December 30, 2022): 785–92. http://dx.doi.org/10.4314/tjs.v48i4.6.

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Preliminary phytochemical screening of aqueous and ethanolic extracts of Hibiscus sabdariffa grown in Tanzania revealed the presence of secondary metabolites like steroids, tannins, saponins, glycosides, terpenoids, flavonoids along with L-ascorbic acid (vitamin C) and iron(II). Furthermore, both leaves and calyces showed antibacterial activities (agar well diffusion method) against selected bacterial species (Escherichia coli, Staphylococcus aureus, Salmonella typhi and Shigella sonnei), but calyces possessed potent antibacterial activities compared to leaves. The results also supported the c

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Petrushina, A. D., Daria M. Slashcheva, N. S. Brynza, N. D. Pirogova, S. V. Sosnovskaya, and A. P. Chernova. "VITAMIN D AND LATENT TUBERCULOSIS INFECTION IN SCHOOLCHILDREN." Russian Pediatric Journal 22, no. 6 (December 15, 2019): 344–48. http://dx.doi.org/10.18821/1560-9561-2019-22-6-344-348.

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The World Health Organization has adopted the global TB strategy for the period of 2016-2035. To achieve its targets, it is necessary to propose and introduce new approaches for the prevention and treatment of latent tuberculosis infection (LTBI) in children and adolescents, as a potential source of active tuberculosis development. In this regard, the use of vitamin D (cholecalciferol) may become promising in combating tuberculosis, since most researchers suppose an adequate level of cholecalciferol to have a positive preventive and therapeutic effect in children with active and latent tubercu

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Shen, Hongwei, and Bingyan Zhan. "Effect of vitamin E on stroke-associated pneumonia." Journal of International Medical Research 48, no. 9 (September 2020): 030006052094965. http://dx.doi.org/10.1177/0300060520949657.

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Objective To study the role of vitamin E in stroke-associated pneumonia. Methods We selected 183 patients with stroke-related pneumonia who were divided into different nutrition groups according to the Mini Nutritional Assessment score. Patients were then administered different doses of vitamin E. Results CD55 and CD47 levels in patients taking vitamin E across different nutrition score groups were better than those in patients who did not use vitamin E. The levels of CD55 and CD47 and the duration of hospitalization were better in the high-dose vitamin E group than in the low-dose vitamin E g

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Hassan, Syed Hafeez ul. "Malnutrition Challenge Therapeutic Strategy." Journal of Aziz Fatimah Medical & Dental College 1, no. 2 (November 19, 2019): 77–78. http://dx.doi.org/10.55279/jafmdc.v1i2.58.

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SUMMARYMalnutrition is a broad term which describes nutritional related diseases caused by over and under nutrition, found in the hospitals or in famines. Therefore malnutrition can be categorized as over nutrition and obesity resulting into metabolic syndrome characterized by hyperglycemia, hypertension, dyslipidemia, hyperuricemia and decreased vitamin D in some cases. Whereas under nutrition with inflammation can be as a result of chronic illness, acute illness/injury or simply decreased dietary intake when there is no inflammation. The initial assessment can be done by simple clinical meas

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Khodjaeva, Zulfiya A. "THERAPEUTIC APPROACH TO THE TREATMENT OF PATIENTS WITH INFLAMMATORY DORSALGIA." Oriental Journal of Medicine and Pharmacology 02, no. 02 (April 1, 2022): 1–12. http://dx.doi.org/10.37547/supsci-ojmp-02-02-01.

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After analyzing the effectiveness of SWT and vitamin D in the complex treatment of patients with dorsalgia, we came to the conclusion that the use of SWT is safe and effective, has an analgesic systemic effect, which normalizes local microcirculation and makes it possible to reduce the dose of prescribed drugs, reducing the risk of side effects of NSAIDs. in patients with dorsalgia of inflammatory origin.

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Gatera, Vesara Ardhe, Rizky Abdulah, Ida Musfiroh, Raden Tina Dewi Judistiani, and Budi Setiabudiawan. "Updates on the Status of Vitamin D as a Risk Factor for Respiratory Distress Syndrome." Advances in Pharmacological Sciences 2018 (September 30, 2018): 1–6. http://dx.doi.org/10.1155/2018/8494816.

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To update the guidelines regarding vitamin D status in respiratory distress syndrome, we reviewed recent human and animal studies on the benefits of vitamin D in respiratory distress. We searched PubMed and ProQuest for studies on the use of vitamin D from 2009 to 2017. The common parameters in these studies included the use of lung tissue, phospholipids, blood, and plasma to assess the effects of vitamin D on respiratory syndrome. The metabolized form of vitamin D used in these studies was 1,25(OH)2D3 in animal studies and 25(OH)D in human studies. Vitamin D supplementation decreases the risk

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Knepper, J., E. Ramacciotti, and T. W. Wakefield. "Novel anticoagulants: a discussion of clinical use in the treatment and prevention of venous thromboembolism." Phlebology: The Journal of Venous Disease 26, no. 1 (January 14, 2011): 3–7. http://dx.doi.org/10.1258/phleb.2010.010023.

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Traditional therapeutic oral anticoagulation strategies often require invasive dosing or monitoring. Vitamin K antagonists (VKAs) have a large number of interactions, delayed onset requires frequent dose monitoring, and they have a small margin between therapeutic dose and bleeding complications. Novel oral anticoagulants, such as dabigatran, rivaroxaban and apixaban, are being developed to prevent those VKAs drawbacks. Besides oral bioavailability, those compounds are designed to require minimal to no monitoring and have a favourable safety profile. This review reports efficacy and safety dat

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Kashiouris, Markos G., Michael L’Heureux, Casey A. Cable, Bernard J. Fisher, Stefan W. Leichtle, and Alpha A. Fowler. "The Emerging Role of Vitamin C as a Treatment for Sepsis." Nutrients 12, no. 2 (January 22, 2020): 292. http://dx.doi.org/10.3390/nu12020292.

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Sepsis, a life-threatening organ dysfunction due to a dysregulated host response to infection, is a leading cause of morbidity and mortality worldwide. Decades of research have failed to identify any specific therapeutic targets outside of antibiotics, infectious source elimination, and supportive care. More recently, vitamin C has emerged as a potential therapeutic agent to treat sepsis. Vitamin C has been shown to be deficient in septic patients and the administration of high dose intravenous as opposed to oral vitamin C leads to markedly improved and elevated serum levels. Its physiologic r

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Sartori, Alexandrina, SofiaFernanda Gonçalves Zorzella-Pezavento, LuizaAyumi Nishiyama Mimura, MarinaBonifácio Denadai, WilliamDanilo Fernandes de Souza, and ThaisFernanda de Campos Fraga-Silva. "Is there a window of opportunity for the therapeutic use of vitamin D in multiple sclerosis?" Neural Regeneration Research 17, no. 9 (2022): 1945. http://dx.doi.org/10.4103/1673-5374.335139.

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Bania, Angelina, Konstantinos Pitsikakis, Georgios Mavrovounis, Maria Mermiri, Eleftherios T. Beltsios, Antonis Adamou, Vasiliki Konstantaki, et al. "Therapeutic Vitamin D Supplementation Following COVID-19 Diagnosis: Where Do We Stand?—A Systematic Review." Journal of Personalized Medicine 12, no. 3 (March 8, 2022): 419. http://dx.doi.org/10.3390/jpm12030419.

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Vitamin D has known immunomodulatory activity and multiple indications exist supporting its potential use against SARS-CoV-2 infection in the setting of the current pandemic. The purpose of this systematic review is to examine the efficacy of vitamin D administered to adult patients following COVID-19 diagnosis in terms of length of hospital stay, intubation, ICU admission and mortality rates. Therefore, PubMed and Scopus databases were searched for original articles referring to the aforementioned parameters. Of the 1376 identified studies, eleven were finally included. Vitamin D supplements,

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Janjusevic, Milijana, Alessandra Lucia Fluca, Giulia Gagno, Alessandro Pierri, Laura Padoan, Annamaria Sorrentino, Antonio Paolo Beltrami, Gianfranco Sinagra, and Aneta Aleksova. "Old and Novel Therapeutic Approaches in the Management of Hyperglycemia, an Important Risk Factor for Atherosclerosis." International Journal of Molecular Sciences 23, no. 4 (February 20, 2022): 2336. http://dx.doi.org/10.3390/ijms23042336.

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Hyperglycemia is considered one of the main risk factors for atherosclerosis, since high glucose levels trigger multiple pathological processes, such as oxidative stress and hyperproduction of pro-inflammatory mediators, leading to endothelial dysfunction. In this context, recently approved drugs, such as glucagon-like-peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2i), could be considered a powerful tool for to reduce glucose concentration and cardiovascular risk. Interestingly, many patients with type 2 diabetes mellitus (T2DM) and insulin resistanc

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Lordi, Alexis, Nida Ansari, Michael Maroules, and Anusha Manjegowda. "Splenomegaly in a Patient with a History of Pernicious Anemia; the Potential Therapeutic Effects of B12 Therapy." Case Reports in Hematology 2022 (April 11, 2022): 1–3. http://dx.doi.org/10.1155/2022/2854520.

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Splenomegaly is manifested by a variety of etiologies, one of which is macrocytic anemia. Macrocytic anemia has multiple causes in itself that include; folate (Vitamin B9) and Cobalamin (vitamin B12) deficiencies. In this case report, we present a patient with a history of pancytopenia, macrocytic anemia and vitamin B12 deficiency, who underwent a splenectomy. The differential diagnoses for the cause of the patient’s splenomegaly included: lymphoma, infiltrative disease, and idiopathic splenomegaly. The pathology report from the splenectomy did not reveal any evidence of lymphoma or infiltrati

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Pedraza-Chaverri, José, Laura G. Sánchez-Lozada, Horacio Osorio-Alonso, Edilia Tapia, and Alexandra Scholze. "New Pathogenic Concepts and Therapeutic Approaches to Oxidative Stress in Chronic Kidney Disease." Oxidative Medicine and Cellular Longevity 2016 (2016): 1–21. http://dx.doi.org/10.1155/2016/6043601.

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In chronic kidney disease inflammatory processes and stimulation of immune cells result in overproduction of free radicals. In combination with a reduced antioxidant capacity this causes oxidative stress. This review focuses on current pathogenic concepts of oxidative stress for the decline of kidney function and development of cardiovascular complications. We discuss the impact of mitochondrial alterations and dysfunction, a pathogenic role for hyperuricemia, and disturbances of vitamin D metabolism and signal transduction. Recent antioxidant therapy options including the use of vitamin D and

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Bender, David A. "Non-nutritional uses of vitamin B6." British Journal of Nutrition 81, no. 1 (January 1999): 7–20. http://dx.doi.org/10.1017/s0007114599000082.

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Vitamin B6is a water-soluble vitamin, and is readily metabolized and excreted, so it has generally been assumed to have negligible toxicity, although at very high levels of intake it can cause peripheral nerve damage. Nutritional deficiency disease is extremely rare, although a significant proportion of the population shows biochemical evidence of inadequate status, despite apparently adequate levels of intake. The vitamin has been used to treat a wide variety of conditions, which may or may not be related to inadequate intake. In some conditions use of vitamin B6supplements has been purely em

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GARG, RAVENDRA, NIRPENDRA SINGH, and ANURADHA DUBE. "Intake of nutrient supplements affects multiplication ofLeishmania donovaniin hamsters." Parasitology 129, no. 6 (November 18, 2004): 685–91. http://dx.doi.org/10.1017/s0031182004006055.

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The role of the essential nutrients, vitamins A,B (complex), C and E and iron, as prophylactic as well as supportive therapy in experimental visceral leishmaniasis (VL), was studied in hamsters. Prophylactic administration of vitamin C (50, 100 and 250 mg/kg) from day15 to day 0 (15 doses) significantly reduced the intake ofLeishmania donovaniin hamsters but had no therapeutic effect. In contrast, vitamins A,B complex and E and iron, whether used prophylactically or therapeutically, promoted parasite multiplication. The efficacy of sodium stibogluconate, a reference antileishmanial drug, was a

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Haamit Abba-Kabir, Claude-Audrey Meguieze, Esther Voundi Voundi, Eric Nseme Etouckey, Carlin Ntoukem Mbakop, and Paul Koki Ndombo. "Therapeutic use and covid-19 in a pediatric population in Yaoundé." World Journal of Advanced Research and Reviews 15, no. 1 (July 30, 2022): 311–16. http://dx.doi.org/10.30574/wjarr.2022.15.1.0657.

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Introduction: The COVID-19 pandemic is an airborne or hand borne viral respiratory disease. Its treatment is not yet totally codified. Objective: The aim of this study was to describe the therapeutic remedies of COVID-19 in a paediatric population in Yaoundé. Materials and methods: A cross sectional descriptive study was conducted in Nkolndongo health district from January to May 2021 for a duration of 5 months. All patients aged 0 to 19 years, tested COVID-19 by RT-PCR and managed in the Nkolndongo health district were included. Results were analysed using IBM SPSS.23.0 software and data expr

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Iamsawat, Supinya, Anusara Daenthanasanmak, and Xue-Zhong Yu. "Vitamin C Stabilizes CD8iTregs and Enhances Their Therapeutic Potential in Controlling GvHD and Leukemia Relapse." Blood 132, Supplement 1 (November 29, 2018): 4532. http://dx.doi.org/10.1182/blood-2018-99-117036.

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Abstract Graft-versus-host disease (GvHD) remains a leading cause of non-relapse mortality after allogeneic hematopoietic cell transplantation (allo-HCT). The imbalance between T effector (Teffs) and regulatory cells (Tregs) is a defined characteristic of GvHD. Therefore, promoting Tregs for controlling GvHD has drawn an intense interest in preclinical and clinical studies of allo-HCT. Although CD4 Tregs (CD4+Foxp3+) have been shown to effectively prevent GvHD, they impaired graft-versus-leukemia (GVL) effect. Our lab has previously demonstrated that CD8 iTregs (CD8+Foxp3+) not only suppressed

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Jeetendra, Singh, and Baheti Tushar. "Metformin Use and Vitamin B₁₂ Deficiency in Patients with Type-2 Diabetes Mellitus." MVP Journal of Medical Sciences 3, no. 1 (February 29, 2016): 67. http://dx.doi.org/10.18311/mvpjms/2016/v3/i1/731.

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Metformin is commonly used oral hypoglycaemic agent in the treatment of type-2 Diabetes Mellitus (DM). One of the important side effect of long term metformin therapy is malabsorption of vitamin B<sub>12</sub> which could lead to megaloblastic anemia and peripheral neuropathy. Therefore annual screening of serum vitamin B<sub>12</sub> level or serum methylmalonic acid (MMA)/serum homocysteine level should be done in cases taking metformin for more than four to five years with average dose of &gt;1g per day, even in the absence of haematological or neurological abnor

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Simonetti, Sérgio Henrique, Gustavo Bernardes de Figueiredo Oliveira, Fabiana Cristina Lourenço, and França João Ítalo Dias. "Accuracy of an adherence score and time in therapeutic range among patients on chronic use of vitamin K antagonists." Research, Society and Development 10, no. 8 (July 16, 2021): e59510816523. http://dx.doi.org/10.33448/rsd-v10i8.16523.

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To validate and analyze the accuracy of the Simonetti adherence score among patients on chronic use of vitamin K antagonists and their time in therapeutic range (TTR) of the international normalized ratio as a measure of quality of anticoagulation. A prospective cohort study with a nonrandomized intervention in patients from an anticoagulation center of a public hospital. Baseline data were collected from May to September 2017, and follow-up data were obtained eight months after a nurse-led educational intervention, which was given to all patients after consent form and after applying the adhe

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Farahmand, P., and J. D. Ringe. "Therapeutic options in male osteoporosis." Osteologie 22, no. 04 (2013): 271–76. http://dx.doi.org/10.1055/s-0038-1630134.

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SummaryOsteoporosis in men is increasingly recognized as an important public health problem but affected patients are still under-diagnosed and -treated. As in women the diagnostic and therapeutic strategy has to be adapted to the individual case. In the practical management it is very important to detect possible causes of secondary osteoporosis, to explain the possibilities of basic therapy counteracting individual risk factors and communicate that osteoporosis is a chronic disease and adherence to a long-term treatment is crucial. In established severe osteoporosis a careful analgesic thera

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Bode, C., and M. Moser. "Antikoagulation bei Vorhofflimmern." Hämostaseologie 32, no. 01 (2012): 37–39. http://dx.doi.org/10.5482/ha-1186.

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SummaryAtrial fibrillation is one of the most frequent reasons for therapeutic anticoagulation in everyday practice. Oral vitamin K antagonists such as Marcumar have been state of the art anticoagulants to prevent thrombembolic events in patients with atrial fibrillation and additional risk factors. But these drugs are accompanied by disadvantages such as increased bleeding risk and impaired quality of life caused by interactions with food or other medications as well as frequent controls of INRs.The new anticoagulants apixaban, rivaroxaban and dabigatran are direct antagonists of coagulation

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Brum, Doralina Guimarães, Elizabeth Regina Comini-Frota, Claúdia Cristina F. Vasconcelos, and Elza Dias-Tosta. "Supplementation and therapeutic use of vitamin D in patients with multiple sclerosis: Consensus of the Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology." Arquivos de Neuro-Psiquiatria 72, no. 2 (February 2014): 152–56. http://dx.doi.org/10.1590/0004-282x20130252.

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Multiple sclerosis (MS) is an inflammatory, autoimmune, demyelinating, and degenerative central nervous system disease. Even though the etiology of MS has not yet been fully elucidated, there is evidence that genetic and environmental factors interact to cause the disease. Among the main environmental factors studied, those more likely associated with MS include certain viruses, smoking, and hypovitaminosis D. This review aimed to determine whether there is evidence to recommend the use of vitamin D as monotherapy or as adjunct therapy in patients with MS. We searched PUBMED, EMBASE, COCHRANNE

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Sun, Hui, Xiaoshuai Zhu, Dan Li, and Tao Cheng. "Effects of a compound vitamin B mixture in combination with GeneTime® on radiation-induced oral mucositis." Journal of International Medical Research 47, no. 5 (April 2, 2019): 2126–34. http://dx.doi.org/10.1177/0300060519831171.

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Objective Both compound vitamin B mixtures and GeneTime® have been used in treatment of oral inflammation. This study aimed to assess the therapeutic effects of a compound vitamin B mixture combined with GeneTime® on radiation-induced oral mucositis. Methods A total of 100 patients with radiation-induced oral mucositis were randomly divided into a control group (vitamin B alone; n = 50 patients) and an observation group (vitamin B plus GeneTime®, n = 50 patients). Clinical outcomes were compared between the two groups for the following 3 weeks. Results The observation group had a significantly

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