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Journal articles on the topic 'Vitamin B6. Pyridoxine'

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Published: 4 June 2021

Last updated: 3 February 2022

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1

Vucijak, Nevena, Slobodan Petrovic, Dejan Bezbradica, Zorica Knezevic-Jugovic, and Dusan Mijin. "Synthesis of B6 vitamin." Chemical Industry 63, no. 4 (2009): 353–60. http://dx.doi.org/10.2298/hemind0904353v.

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The importance of vitamin B6 has been known since its discovery in the 1940's. Chemical tests, elestrometric titration determinations, and absorption spectrum studies showed that this vitamin exists in three major chemical forms: pyridoxine (an alcohol), pyridoxal (an aldehyde), and pyridoxamine (a primary amine). Vitamin B6 is needed for more than 100 enzymes involved in protein metabolism, and it is assumed that this vitamin is cofactor of metabolic processes more important than any other substance. A deficiency of vitamin B6 in the human diet leads to severe disorders. Vitamin B6 is necessa

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BEYNON, Robert J., Deborah M. LEYLAND, Richard P. EVERSHED, Richard H. T. EDWARDS, and Stephen P. COBURN. "Measurement of the turnover of glycogen phosphorylase by GC/MS using stable isotope derivatives of pyridoxine (vitamin B6)." Biochemical Journal 317, no. 2 (1996): 613–19. http://dx.doi.org/10.1042/bj3170613.

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The majority of vitamin B6 in the body is in skeletal muscle, bound as the cofactor pyridoxal 5´-phosphate to one abundant protein, glycogen phosphorylase. Previous work has established that radiolabelled vitamin B6 can be used as a turnover label for glycogen phosphorylase. In this study, a stable isotope derivative of pyridoxine {dideuterated pyridoxine; 3-hydroxy-4-(hydroxymethyl)-5-[hydroxymethyl-2H2]-2-methylpyridine} ([2H2]PN) has been used as a metabolic tracer to study the kinetics of labelling of the body pools of vitamin B6 in mice. A non-invasive method was developed in which the is

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Obeid, Rima, Juergen Geisel, and Wilfred A. Nix. "4-Pyridoxic Acid/Pyridoxine Ratio in Patients with Type 2 Diabetes is Related to Global Cardiovascular Risk Scores." Diagnostics 9, no. 1 (2019): 28. http://dx.doi.org/10.3390/diagnostics9010028.

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Background: Vascular diseases are multifactorial and several risk factors may have synergetic effect on the global vascular risk. Among patients with diabetes, we investigated whether vitamin B6 species differ according to global cardiovascular risk. Methods: The present observational study included 122 patients with type 2 diabetes (mean (SD) age = 69.9 (9.1) years; 50% men). Concentrations of vitamin B6 vitamers were measured. Classical blood biomarkers and risk factors were used to compute a multivariate risk score. Results: Plasma concentrations of 4-pyridoxic acid were higher in patients

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4

Richts, Björn, and Fabian M. Commichau. "Underground metabolism facilitates the evolution of novel pathways for vitamin B6 biosynthesis." Applied Microbiology and Biotechnology 105, no. 6 (2021): 2297–305. http://dx.doi.org/10.1007/s00253-021-11199-w.

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Abstract The term vitamin B6 is a designation for the vitamers pyridoxal, pyridoxamine, pyridoxine and the respective phosphate esters pyridoxal-5′-phosphate (PLP), pyridoxamine-5′-phosphate and pyridoxine-5′-phosphate. Animals and humans are unable to synthesise vitamin B6. These organisms have to take up vitamin B6 with their diet. Therefore, vitamin B6 is of commercial interest as a food additive and for applications in the pharmaceutical industry. As yet, two naturally occurring routes for de novo synthesis of PLP are known. Both routes have been genetically engineered to obtain bacteria o

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Ibrahim, Ghada Rashad, Iltaf Shah, Salah Gariballa, Javed Yasin, James Barker, and Syed Salman Ashraf. "Significantly Elevated Levels of Plasma Nicotinamide, Pyridoxal, and Pyridoxamine Phosphate Levels in Obese Emirati Population: A Cross-Sectional Study." Molecules 25, no. 17 (2020): 3932. http://dx.doi.org/10.3390/molecules25173932.

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Water-soluble vitamins like B3 (nicotinamide), B6 (pyridoxine), and B9 (folic acid) are of utmost importance in human health and disease, as they are involved in numerous critical metabolic reactions. Not surprisingly, deficiencies of these vitamins have been linked to various disease states. Unfortunately, not much is known about the physiological levels of B6 vitamers and vitamin B3 in an ethnically isolated group (such as an Emirati population), as well as their relationship with obesity. The aim of the present study was to quantify various B6 vitamers, as well as B3, in the plasma of obese

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Salvati, Louis M., Sean C. McClure, Todime M. Reddy, and Nicholas A. Cellar. "Simultaneous Determination of Total Vitamins B1, B2, B3, and B6 in Infant Formula and Related Nutritionals by Enzymatic Digestion and LC-MS/MS: Single-Laboratory Validation, First Action 2015.14." Journal of AOAC INTERNATIONAL 99, no. 3 (2016): 776–85. http://dx.doi.org/10.5740/jaoacint.15-0315.

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Abstract This method provides simultaneous determination of total vitamins B1, B2, B3, and B6 in infant formula and related nutritionals (adult and infant). The method was given First Action for vitamins B1, B2, and B6, but not B3, during the AOAC Annual Meeting in September 2015. The method uses acid phosphatase to dephosphorylate the phosphorylated vitamin forms. It then measures thiamine (vitamin B1); riboflavin (vitamin B2); nicotinamide and nicotinic acid (vitamin B3); and pyridoxine, pyridoxal, and pyridoxamine (vitamin B6) from digested sample extract by liquid chromatography-tandem mas

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Edwards, P., P. K. Liu, and G. A. Rose. "A simple liquid-chromatographic method for measuring vitamin B6 compounds in plasma." Clinical Chemistry 35, no. 2 (1989): 241–45. http://dx.doi.org/10.1093/clinchem/35.2.241.

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Abstract This relatively simple high-performance liquid chromatographic (HPLC) method for measuring all seven known forms of vitamin B6 in plasma from individuals supplemented with pyridoxine hydrochloride shows good analytical recovery (85-98%) and precision. Within-run and between-run CVs for plasmas supplemented with standards were 4% and 7%, respectively. The major forms of B6 found in unsupplemented plasma from normal subjects were pyridoxal phosphate and 4-pyridoxic acid, with pyridoxal just detectable. The HPLC procedure correlated well (r = 0.94) with a modification of an enzymatic met

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8

Hardy, Ronald W., Edmundo Casillas, and Toshiro Masumoto. "Determination of Vitamin B6 Deficiency in Rainbow Trout (Salmo gairdneri) by Liver Enzyme Assay and HPLC Analysis." Canadian Journal of Fisheries and Aquatic Sciences 44, no. 1 (1987): 219–22. http://dx.doi.org/10.1139/f87-030.

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Rainbow trout (Salmo gairdneri), initially averaging 125 g, were fed a complete or a pyridoxine-deficient diet for 14 wk. Vitamin B6 status was evaluated biweekly by direct measurement of liver pyridoxine and pyridoxal levels by HPLC and by determining pyridoxal-5′-phosphate-enhanced liver aspartate aminotransferase (ASAT) activity. By 14 wk, mortality had severely reduced the number of fish remaining in the pyridoxine-deficient group. At 14 wk, no significant differences in liver pyridoxine and pyridoxal levels were detected between the trout fed the complete or pyridoxine-deficient diet. Sig

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Sullivan, DW, RC Peterson, CV Mujer, and SC Gad. "A 7-day intravenous toxicity study and neurotoxicity assessment of pyridorin in Sprague-Dawley rats." Human & Experimental Toxicology 36, no. 7 (2016): 718–26. http://dx.doi.org/10.1177/0960327116661023.

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Pyridorin®, a naturally occurring metabolite of vitamin B6 that inhibits and scavenges reactive oxygen species, is being developed as a potential therapeutic for acute kidney injury. An investigational new drug application (IND) was opened for Pyridorin in support of its ongoing oral drug clinical development program. Currently, a Pyridorin intravenous (IV) formulation is being developed for use in surgical patients. To support the IND for Pyridorin, a full battery of nonclinical Good Laboratory Practice compliant studies was performed with no neurological or behavioral signs of toxicity seen

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Midttun, Øivind, Steinar Hustad, Einar Solheim, Jørn Schneede, and Per M. Ueland. "Multianalyte Quantification of Vitamin B6 and B2 Species in the Nanomolar Range in Human Plasma by Liquid Chromatography–Tandem Mass Spectrometry." Clinical Chemistry 51, no. 7 (2005): 1206–16. http://dx.doi.org/10.1373/clinchem.2005.051169.

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Abstract Background: Homocysteine, a risk factor of cardiovascular disease, cognitive disorders, and pregnancy complications, exists at a point of metabolic convergence of several B vitamins, including vitamins B6 and B2 (riboflavin). Measurement of the various forms of these vitamins may be useful for the study of hyperhomocysteinemia as well as for the assessment of vitamin status. Methods: Plasma (60 μL) was deproteinized by mixing with an equal volume of 50 g/L trichloroacetic acid that contained d2-pyridoxal 5′-phosphate, d3-pyridoxal, and d8-riboflavin as internal standards. Pyridoxal (P

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Said, Hamid M., Alvaro Ortiz, and Thomas Y. Ma. "A carrier-mediated mechanism for pyridoxine uptake by human intestinal epithelial Caco-2 cells: regulation by a PKA-mediated pathway." American Journal of Physiology-Cell Physiology 285, no. 5 (2003): C1219—C1225. http://dx.doi.org/10.1152/ajpcell.00204.2003.

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Vitamin B6 is essential for cellular functions and growth due to its involvement in important metabolic reactions. Humans and other mammals cannot synthesize vitamin B6 and thus must obtain this micronutrient from exogenous sources via intestinal absorption. The intestine, therefore, plays a central role in maintaining and regulating normal vitamin B6 homeostasis. Due to the water-soluble nature of vitamin B6 and the demonstration that transport of other water-soluble vitamins in intestinal epithelial cells involves specialized carrier-mediated mechanisms, we hypothesized that transport of vit

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Sharma, Pankaja, Soo Min Han, Nicola Gillies, et al. "Circulatory and Urinary B-Vitamin Responses to Multivitamin Supplement Ingestion Differ between Older and Younger Adults." Nutrients 12, no. 11 (2020): 3529. http://dx.doi.org/10.3390/nu12113529.

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Multivitamin and mineral (MVM) supplements are frequently used amongst older populations to improve adequacy of micronutrients, including B-vitamins, but evidence for improved health outcomes are limited and deficiencies remain prevalent. Although this may indicate poor efficacy of supplements, this could also suggest the possibility for altered B-vitamin bioavailability and metabolism in older people. This open-label, single-arm acute parallel study, conducted at the Liggins Institute Clinical Research Unit in Auckland, compared circulatory and urinary B-vitamer responses to MVM supplementati

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13

Martin, Frederic, Ester Campos Giménez, and Erik Konings. "New Methods for the Analysis of Water-Soluble Vitamins in Infant Formula and Adult/Pediatric Nutritionals." Journal of AOAC INTERNATIONAL 99, no. 1 (2016): 19–25. http://dx.doi.org/10.5740/jaoacint.15-0245.

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Abstract Water-soluble vitamins (WSVs) are a group of organic compounds which are essential micronutrients. WSVs could be divided between the B complex group and vitamin C (l-ascorbic acid). Within the B complex group, eight vitamins are recognized: vitamins B1 (thiamin), B2 (riboflavin), B3 (niacin or niacinamide), B5 (pantothenic acid), B6 (pyridoxine, pyridoxal, or pyridoxamine), B7 (biotin), B9 (folic acid), and B12 (various cobalamins). This paper reviews the new methods for the analysis of these vitamins, with a focus on infant formula and adult nutritionals.

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14

Morimoto, Kohkichi, Akira Kawada, Masataro Hiruma, and Akira Ishibashi. "Photosensitivity from pyridoxine hydrochloride (vitamin B6)." Journal of the American Academy of Dermatology 35, no. 2 (1996): 304–5. http://dx.doi.org/10.1016/s0190-9622(96)90654-4.

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15

Beg, M. A., J. L. Fistein, and D. M. Storey. "The host-parasite relationships in pyridoxine (vitamin B6) deficient cotton rats infected with Litomosoides carinii (Nematoda: Filaroidea)." Parasitology 111, no. 1 (1995): 111–18. http://dx.doi.org/10.1017/s0031182000064660.

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SUMMARYThis paper demonstrates that the establishment and growth of the filarial nematode parasite, Litomosoides carinii, is reduced in pyridoxine-deficient cotton rats. Young cotton rats were assigned to one of three dietary groups: vitamin B6-deficient cotton rats (B6 –AL) were fed a pyridoxine-free diet ad libitum; pair-fed controls (B6 + PF) were fed the same amount of pyridoxine-free diet as animals in the deficient group and given daily oral supplements of 100 μg pyridoxine; and pyridoxine-sufficient controls (B6 + AL) were fed the pyridoxine-free diet ad libitum and supplemented daily w

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Waldmann, A., B. Dörr, JW Koschizke, C. Leitzmann, and A. Hahn. "Dietary intake of vitamin B6 and concentration of vitamin B6 in blood samples of German vegans." Public Health Nutrition 9, no. 6 (2006): 779–84. http://dx.doi.org/10.1079/phn2005895.

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AbstractObjectiveThe study aimed to evaluate the dietary vitamin B6 intake and determine the vitamin B6 concentration in blood samples of German vegans.Design and settingCross-sectional study with 33 examination sites all over Germany.SubjectsNinety-three vegans (50 females) with a mean (±standard deviation (SD)) age of 43.7 ± 15.7 years who took no vitamin supplements.MethodsDietary intake was assed using a semi-quantitative food-frequency questionnaire. Erythrocyte aspartate aminotransferase activity coefficient (EAST-AC) was calculated as the ratio of stimulated (pyridoxal 5'-phosphate adde

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Sallabi, Sundus M., Aishah Alhmoudi, Manal Alshekaili, and Iltaf Shah. "Determination of Vitamin B3 Vitamer (Nicotinamide) and Vitamin B6 Vitamers in Human Hair Using LC-MS/MS." Molecules 26, no. 15 (2021): 4487. http://dx.doi.org/10.3390/molecules26154487.

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Water-soluble B vitamins participate in numerous crucial metabolic reactions and are critical for maintaining our health. Vitamin B deficiencies cause many different types of diseases, such as dementia, anaemia, cardiovascular disease, neural tube defects, Crohn’s disease, celiac disease, and HIV. Vitamin B3 deficiency is linked to pellagra and cancer, while niacin (or nicotinic acid) lowers low-density lipoprotein (LDL) and triglycerides in the blood and increases high-density lipoprotein (HDL). A highly sensitive and robust liquid chromatography–tandem mass spectroscopy (LC/MS-MS) method was

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Nahar, Nilufar, Abida Sultana, Md Sharear Saon, and Mohammad Shoeb. "Evaluation of Vitamin B1, B2 and B6 Tablets in Bangladesh by UV-Vis Spectrophotometer." Indian Journal of Pharmaceutical and Biological Research 4, no. 04 (2016): 32–38. http://dx.doi.org/10.30750/ijpbr.4.4.8.

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Thiamine hydrochloride (vitamin B1), riboflavin (vitamin B2) and pyridoxine hydrochloride (vitamin B6) were assayed in pharmaceutical dosages form. Thiamine hydrochloride of 100 mg dose of six different companies, riboflavin of 5 mg dose of five different companies and pyridoxine hydrochloride 20 and 25 mg dosages of two different companies of Bangladesh were extracted from the tablets, cleaned up and their active ingredients were evaluated by UV-Vis spectrophotometer at 432, 445 and 292 nm, respectively. Evaluation was carried out with respect to calibration curves of their standard reference

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Dakshinamurti, Shyamala, and Krishnamurti Dakshinamurti. "Antihypertensive and neuroprotective actions of pyridoxine and its derivatives." Canadian Journal of Physiology and Pharmacology 93, no. 12 (2015): 1083–90. http://dx.doi.org/10.1139/cjpp-2015-0098.

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Vitamin B6 plays a crucial role in the nervous system as the amino acid decarboxylases involved in the synthesis of all putative neurotransmitters requires the coenzyme pyridoxal phosphate. Vitamin B6 in its various forms has antioxidant properties. Pyridoxal phosphate has a role in regulating cellular calcium transport through both the voltage-mediated and ATP-mediated purinergic mechanisms of cellular calcium influx and, hence, has a role in the control of hypertension. Pharmacological doses of vitamin B6 appear to decrease the high blood pressure associated with both genetic and nongenetic

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Said, Hamid M., Alvaro Ortiz, and Nike D. Vaziri. "Mechanism and regulation of vitamin B6 uptake by renal tubular epithelia: studies with cultured OK cells." American Journal of Physiology-Renal Physiology 282, no. 3 (2002): F465—F471. http://dx.doi.org/10.1152/ajprenal.00267.2001.

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The kidneys play an important role in regulating vitamin B6 body homeostasis, but limited information exists regarding the mechanism of pyridoxine uptake by renal epithelial cells, and no study exists on its regulation. To address these issues, we used the renal opossum-derived tubular epithelial (opossum kidney; OK) cells and found pyridoxine uptake to 1) be temperature and energy dependent, 2) be pH dependent, with a higher uptake at alkaline or neutral buffer pH compared with acidic pH, 3) be Na+independent, 4) involve a saturable component (apparent Michaelis- Menten constant of 2.40 ± 0.2

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Baltrusch, Simone. "The Role of Neurotropic B Vitamins in Nerve Regeneration." BioMed Research International 2021 (July 13, 2021): 1–9. http://dx.doi.org/10.1155/2021/9968228.

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Damage and regeneration naturally occur in the peripheral nervous system. The neurotropic B vitamins thiamine (B1), pyridoxine (B6), and cobalamin (B12) are key players, which maintain the neuronal viability in different ways. Firstly, they constantly protect nerves against damaging environmental influences. While vitamin B1 acts as a site-directed antioxidant, vitamin B6 balances nerve metabolism, and vitamin B12 maintains myelin sheaths. However, nerve injury occurs at times, because of an imbalance between protective factors and accumulating stress and noxae. This will result in the so-call

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Samour, Jaime, Janine Perlman, Jörg Kinne, Vijay Baskar, Ulrich Wernery, and Gerry Dorrestein. "VITAMIN B6 (PYRIDOXINE HYDROCHLORIDE) TOXICOSIS IN FALCONS." Journal of Zoo and Wildlife Medicine 47, no. 2 (2016): 601–8. http://dx.doi.org/10.1638/2015-0172.1.

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Wu, Min, Qi Xu, Åke Strid, Jaime M. Martell, and Leif A. Eriksson. "Theoretical Study of Pyridoxine (Vitamin B6) Photolysis." Journal of Physical Chemistry A 115, no. 46 (2011): 13556–63. http://dx.doi.org/10.1021/jp205724k.

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Kashanian, M., R. Mazinani, S. Jalalmanesh, and S. Babayanzad Ahari. "Pyridoxine (vitamin B6) therapy for premenstrual syndrome." International Journal of Gynecology & Obstetrics 96, no. 1 (2006): 43–44. http://dx.doi.org/10.1016/j.ijgo.2006.09.014.

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Srinivasan, Padmanabhan, Vignesh Ramesh, Jie Wu, Christopher Heskett, Brian D. Chu, and Hamid M. Said. "Pyridoxine and pancreatic acinar cells: transport physiology and effect on gene expression profile." American Journal of Physiology-Cell Physiology 317, no. 6 (2019): C1107—C1114. http://dx.doi.org/10.1152/ajpcell.00225.2019.

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Pyridoxine (vitamin B6), an essential micronutrient for normal cell physiology, plays an important role in the function of the exocrine pancreas. Pancreatic acinar cells (PACs) obtain vitamin B6 from circulation, but little is known about the mechanism involved in the uptake process; limited information also exists on the effect of pyridoxine availability on the gene expression profile in these cells. We addressed both these issues in the current investigation using mouse-derived pancreatic acinar 266-6 cells (PAC 266-6) and human primary PACs (hPACs; obtained from organ donors), together with

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OLLILAINEN, V. M. "HPLC analysis of vitamin B6 in foods." Agricultural and Food Science 8, no. 6 (1999): 515–619. http://dx.doi.org/10.23986/afsci.5632.

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The objective of this work was to evaluate the methods for determination of vitamin B6 in foods. To achieve this, the literature review focused on sample treatment and liquid chromatographic analysis of vitamin B6 related compounds. In the experimental part, the chosen sample pretreatment and the high-performance liquid chromatographic (HPLC) method were validated, and used to produce vitamin B6 data on various food items commonly consumed in Finland. The main emphasis of the sample treatment was on the extraction efficiency and the maintenance of the original concentration profile of the vita

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Bor, Mustafa Vakur, Helga Refsum, Marianne R. Bisp, et al. "Plasma Vitamin B6 Vitamers before and after Oral Vitamin B6 Treatment: A Randomized Placebo-controlled Study." Clinical Chemistry 49, no. 1 (2003): 155–61. http://dx.doi.org/10.1373/49.1.155.

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Abstract Background: Vitamin B6 has attracted renewed interest because of its role in homocysteine metabolism and its possible relation to cardiovascular risk. We examined the plasma B6 vitamers, pyridoxal 5′-phosphate (PLP), pyridoxal (PL), pyridoxine (PN), and 4-pyridoxic acid (4-PA) before and after vitamin B6 supplementation. Methods: Patients (n = 90; age range, 38–80 years) undergoing coronary angiography (part of the homocysteine-lowering Western Norway B-Vitamin Intervention Trial) were allocated to the following daily oral treatment groups: (A), vitamin B12 (0.4 mg), folic acid (0.8 m

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S.P.Dange, S. P. Dange, and O. P. Chimankar O.P.Chimankar. "Thermo acoustic Properties of Aqueous B complex vitamin Pyridoxine Hydrochloride (B6)." Indian Journal of Applied Research 3, no. 7 (2011): 576–77. http://dx.doi.org/10.15373/2249555x/july2013/181.

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Lytkin, Alexander I., Olga N. Krutova, Pavel D. Krutov, Victoriya V. Dudar, and Elena Yu Tyunina. "THERMOCHEMICAL STUDY OF ACID-BASE REACTIONS IN AQUEOUS SOLUTION OF PYRIDOXINE." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 63, no. 6 (2020): 25–29. http://dx.doi.org/10.6060/ivkkt.20206306.6183.

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Vitamin B6 is one of the most important vitamins necessary for the life of living organisms. Vitamin B6, which in the body is represented by coenzyme forms - pyridoxal phosphate and pyridoxamine phosphate, is a part of more than 100 enzymes. As the object of study, we chose pyridoxine. The thermal effects of interaction of the solution of pyridoxine with solutions of nitric acid and potassium hydroxide at 298.15K and ionic strength values of 0.25; 0.5 and 0.75 against the background of electrolyte-supporting potassium nitrate were measured with direct calorimetric method. The measurements were

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Mahfouz, Mohamedain M., Sherry Q. Zhou, and Fred A. Kummerow. "Vitamin B6 Compounds are Capable of Reducing the Superoxide Radical and Lipid Peroxide Levels Induced by H2O2 in Vascular Endothelial Cells in Culture." International Journal for Vitamin and Nutrition Research 79, no. 4 (2009): 218–29. http://dx.doi.org/10.1024/0300-9831.79.4.218.

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Pyridoxamine, pyridoxine, and pyridoxal phosphate were tested to examine if they have antioxidant properties. Endothelial cells exposed to 0.5 mM H2O2 for 2 hours increased the superoxide anion and lipid peroxide levels as biomarkers of oxidative stress. The increase of superoxide was mainly due to the activation of NADPH-oxidase by H2O2. Preincubation of the endothelial cells with 0.1 or 1.0 mM of pyridoxamine or pyridoxal phosphate for one-half hour before H2O2 exposure significantly reduced the superoxide and lipid peroxide compared to the cells exposed to H2O2 only. Preincubation of the ce

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Lee, Jazreen H. Q., Yanni Yue, Rakesh Ganguly, and Richard D. Webster. "Electrochemical Study of Pyridoxine (Vitamin B6) in Acetonitrile." ChemElectroChem 2, no. 3 (2014): 412–20. http://dx.doi.org/10.1002/celc.201402340.

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Jacobson, Mark D., Kevin D. Plancher, and William B. Kleinman. "VITAMIN B6 (PYRIDOXINE) THERAPY FOR CARPAL TUNNEL SYNDROME." Hand Clinics 12, no. 2 (1996): 253–57. http://dx.doi.org/10.1016/s0749-0712(21)00308-5.

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Abdou, Heba M., and Mayssaa M. Wahby. "Neuroprotection of Grape Seed Extract and Pyridoxine against Triton-Induced Neurotoxicity." Oxidative Medicine and Cellular Longevity 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/8679506.

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Triton WR-1339 administration causes neurotoxicity. Natural products and herbal extracts can attenuate cerebral injury. In the present study, we investigated the neuroprotective role of grape seed extract and/or vitamin B6 against triton-induced neurotoxicity. Thirty-five adult male albino rats of the Sprague-Dawley strain, weighing 140–145 g, were divided into five groups: control, triton, grape seed extract + triton, grape seed extract + triton + vitamin B6, and vitamin B6 + triton. The hematological and biochemical analyses were carried out. Alteration in iNOS mRNA gene expression was deter

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Nugrahani, Ilma, and Citra Kartini. "DETERMINATION OF THIAMINE HCL (VITAMIN B1) AND PYRIDOXINE HCL (VITAMIN B6) CONTENT IN TABLET BY FTIR." International Journal of Pharmacy and Pharmaceutical Sciences 8, no. 10 (2016): 257. http://dx.doi.org/10.22159/ijpps.2016v8i10.14026.

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<p><strong>Objective: </strong>The combination of thiamine hydrochloride (vitamin B1) with pyridoxine hydrochloride (vitamin B6) has been efficacious to help the metabolism of carbohydrates and amino acids. FTIR (Fourier transform infrared) is a technique widely used in compound identification and determination of functional groups but rarely used for the quantitative purposes. This study aims to obtain a analysis determination method of this vitamin combination simultaneously in tablet dosage form using FTIR.</p><p><strong>Methods: </strong>Amount of

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Woollard, David C., and Harvey E. Indyk. "Rapid Determination of Thiamine, Riboflavin, Pyridoxine, and Niacinamide in Infant Formulas by Liquid Chromatography." Journal of AOAC INTERNATIONAL 85, no. 4 (2002): 945–51. http://dx.doi.org/10.1093/jaoac/85.4.945.

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Abstract A simplified, simultaneous determination of vitamins B1, B2, B3, and B6 in supplemented infant formulas was developed from a single deproteinized sample extract, with analysis by reversed-phase, ion-pair chromatography with an acidified methanol–water mobile phase. The dioctylsulfosuccinate counter-ion facilitates unique retention of the pyridine-based vitamins (niacinamide and pyridoxine) and allows for concurrent measurement of both the pyridoxal and riboflavin 5′-phosphate endogenous components of milk. Other naturally occurring undetected vitamin congeners have minimal analytical

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Kadakal, Ç., R. Ekinci, and A. Yapar. "The Effect of Cooking and Drying on the Water-Soluble Vitamins Content of Bulgur." Food Science and Technology International 13, no. 5 (2007): 349–54. http://dx.doi.org/10.1177/1082013207085688.

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Bulgur is a whole-wheat product cooked, dried, cracked, and sifted for sizing. This paper, evaluated the effect of cooking in beaker (90 and 100°C) and in autoclave at 121°C for 17min and drying in a hot-air oven (60, 70, and 80°C) or sun-drying in open air, on the content of several water-soluble vitamins [thiamin (vitamin B 1), niacin, panthothenic acid (vitamin B5), pyridoxine (vitamin B6), and riboflavin (vitamin B2)]. The content of water-soluble vitamins was analyzed by HPLC. Both cooking and drying had a significant effect ( p<0.05) on the content of water-soluble vitamins of bulgur.

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Yaremko, O. V., та R. A. Pelenio. "АКТИВНІСТЬ АМІНОТРАНСФЕРАЗ У СИРОВАТЦІ КРОВІ ТЕЛЯТ ЗА ДІЇ ПІРИДОКСИНУ ГІДРОХЛОРИДУ". Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 18, № 3(71) (2016): 209–14. http://dx.doi.org/10.15421/nvlvet7148.

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The influence of pyridoxine hydrochloride (vitamin B6) activity in serum aminotransferases in dairy calves growing period (1 to 90 days). Calves control group received basic diet, but research from the first days of life to the basic diet added pyridoxine hydrochloride doses: I group – 1.0; II – 2.0; III – 3.0; IV – 4.0 V and group – 5.0 mg / kg body weight. Blood for the study was before the morning feeding at 1, 5, 21, 60 and 90 days after birth. Research aminotransferase activity was determined by the content of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and the

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Köse, Dursun Ali, Birgül Zumreoglu-Karan, Onur Sahin, and Orhan Büyükgüngör. "Boric acid complexes with thiamine (vitamin B1) and pyridoxine (vitamin B6)." Inorganica Chimica Acta 413 (March 2014): 77–83. http://dx.doi.org/10.1016/j.ica.2013.12.045.

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Matte, J. J., A. Giguère, and C. L. Girard. "Some aspects of the pyridoxine (vitamin B6) requirement in weanling piglets." British Journal of Nutrition 93, no. 5 (2005): 723–30. http://dx.doi.org/10.1079/bjn20051406.

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Four trials were carried out to determine the optimal level of dietary pyridoxine (vitamin B6) and its interaction with riboflavin (vitamin B2) in early-weaned piglets. In Trial 1, twelve piglets were tube-fed graded supplements of B6, 0, 10, 50 or 100 mg/kg. The level of 50 mg/kg maximized B6in red blood cells (P<0·05). In Trial 2, thirty-six piglets were tube-fed with four combinations of B6(0v. 50 mg/kg) and B2(0v. 25 mg/kg). The B6supplement increased (P<0·01) B6in red blood cells. C-peptide and insulin responses to intravenous glucose tended (P<0·08) to or decreased (P<0·03) w

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Montpetit, V. J., S. Dancea, L. Tryphonas, and D. F. Clapin. "Membrane-associated microtubular areays induced in proximal myelinated processes of dorsal root ganglia by large doses of vitamin B6." Proceedings, annual meeting, Electron Microscopy Society of America 44 (August 1986): 368–69. http://dx.doi.org/10.1017/s0424820100143468.

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Very large doses of pyridoxine (vitamin B6) are neurotoxic in humans, selectively affecting the peripheral sensory nerves. We have undertaken a study of the morphological and biochemical aspects of pyridoxine neurotoxicity in an animal model system. Early morphological changes in dorsal root ganglia (DRG) associated with pyridoxine megadoses include proliferation of neurofilaments, ribosomes, rough endoplasmic reticulum, and Golgi complexes. We present in this report evidence of the formation of unique aggregates of microtubules and membranes in the proximal processes of DRG which are induced

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Stolz, Jürgen, Heike J. P. Wöhrmann, and Christian Vogl. "Amiloride Uptake and Toxicity in Fission Yeast Are Caused by the Pyridoxine Transporter Encoded by bsu1+ (car1+)." Eukaryotic Cell 4, no. 2 (2005): 319–26. http://dx.doi.org/10.1128/ec.4.2.319-326.2005.

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ABSTRACT Amiloride, a diuretic drug that acts by inhibition of various sodium transporters, is toxic to the fission yeast Schizosaccharomyces pombe. Previous work has established that amiloride sensitivity is caused by expression of car1 +, which encodes a protein with similarity to plasma membrane drug/proton antiporters from the multidrug resistance family. Here we isolated car1 + by complementation of Saccharomyces cerevisiae mutants that are deficient in pyridoxine biosynthesis and uptake. Our data show that Car1p represents a new high-affinity, plasma membrane-localized import carrier for

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Levine, S., and A. Saltzman. "Pyridoxine (vitamin B6) toxicity: enhancement by uremia in rats." Food and Chemical Toxicology 40, no. 10 (2002): 1449–51. http://dx.doi.org/10.1016/s0278-6915(02)00072-8.

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Szydlowski, Nicolas, Lukas Bürkle, Lucille Pourcel, Michael Moulin, Jürgen Stolz, and Teresa B. Fitzpatrick. "Recycling of pyridoxine (vitamin B6) by PUP1 in Arabidopsis." Plant Journal 75, no. 1 (2013): 40–52. http://dx.doi.org/10.1111/tpj.12195.

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Beg, M. A., and D. M. Storey. "Embryogenesis in Litomosoides carinii from pyridoxine deficient cotton rats." Journal of Helminthology 67, no. 3 (1993): 205–12. http://dx.doi.org/10.1017/s0022149x00013146.

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AbstractPyridoxine (vitamin B6) deficiency was induced in cotton rats which were then infected with the filarial parasite Litomosoides carinii. Embryogenesis was assessed microscopically in worms taken from pyridoxine deficient cotton rats and from various categories of control animals. Embryogenesis was retarded in worms from pyridoxine deficient hosts and more abnormal embryos were present in such worms than in those from control animals.

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Vrolijk, Misha F., Antoon Opperhuizen, Eugène H. J. M. Jansen, Geja J. Hageman, Aalt Bast, and Guido R. M. M. Haenen. "The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function." Toxicology in Vitro 44 (October 2017): 206–12. http://dx.doi.org/10.1016/j.tiv.2017.07.009.

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Rahman, Md Toufiqur, Md Elius Hossain, and MQ Ehsan. "Spectrophotometric and cyclic voltammetric study of interaction of Fe(iii) with vitamin B3 and vitamin B6." Journal of Bangladesh Academy of Sciences 38, no. 2 (2014): 143–53. http://dx.doi.org/10.3329/jbas.v38i2.21339.

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The interaction of Fe(III) with niacin and pyridoxine was investigated by UV-Vis. spectrophotometry. The metal to ligand ratio for Fe(III)- niacin system was found to be approximately 1 : 3 and for Fe(III)-pyridoxine system it was 1 : 1. The redox properties of uncoordinated Fe(III)/Fe(II) system is reversible at platinum electrode and in presence of the ligands the system was found to be quasi-reversible in nature. It was also found that in every case the system was diffusion controlled. DOI: http://dx.doi.org/10.3329/jbas.v38i2.21339 Journal of Bangladesh Academy of Sciences, Vol. 38, No. 2,

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Yamashiro, Takahiro, Tomoya Yasujima, Hamid M. Said, and Hiroaki Yuasa. "pH-dependent pyridoxine transport by SLC19A2 and SLC19A3: Implications for absorption in acidic microclimates." Journal of Biological Chemistry 295, no. 50 (2020): 16998–7008. http://dx.doi.org/10.1074/jbc.ra120.013610.

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SLC19A2 and SLC19A3, also known as thiamine transporters (THTR) 1 and 2, respectively, transport the positively charged thiamine (vitamin B1) into cells to enable its efficient utilization. SLC19A2 and SLC19A3 are also known to transport structurally unrelated cationic drugs, such as metformin, but whether this charge selectivity extends to other molecules, such as pyridoxine (vitamin B6), is unknown. We tested this possibility using Madin-Darby canine kidney II (MDCKII) cells and human embryonic kidney 293 (HEK293) cells for transfection experiments, and also using Caco-2 cells as human intes

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Oshiro, Marilena, Kimiyo Nonoyama, Raimundo Antônio Gomes Oliveira, and Orlando Cesar de Oliveira Barretto. "Red cell aspartate aminotransferase saturation with oral pyridoxine intake." Sao Paulo Medical Journal 123, no. 2 (2005): 54–57. http://dx.doi.org/10.1590/s1516-31802005000200004.

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CONTEXT AND OBJECTIVE: The coenzyme of aspartate aminotransferase is pyridoxal phosphate, generated from fresh vegetables containing pyridoxine. Vitamin B6-responsive sideroblastic anemia, myelofibrosis and Peyronie’s syndrome respond to high pyridoxine doses. The objective was to investigate the oral pyridoxine oral dose that would lead to maximized pyridoxal phosphate saturation of red cell aspartate aminotransferase. DESIGN AND SETTING: Controlled trial, in Hematology Division of Instituto Adolfo Lutz. METHODS: Red cell aspartate aminotransferase activity was assayed (before and after) in n

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McLachlan, Richard S., and William F. Brown. "Pyridoxine Dependent Epilepsy with Iatrogenic Sensory Neuronopathy." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 22, no. 1 (1995): 50–51. http://dx.doi.org/10.1017/s0317167100040506.

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ABSTRACT:An 18-year-old man was treated from birth with chronic high dose pyridoxine (vitamin B6) up to 2000 mg per day for pyridoxine-dependent seizures. Within two years of onset of treatment, he developed a sensory neuropathy which did not progress over the following 16 years. Electrophysiological studies were consistent with a pure sensory neuronopathy expressed as centripetal degeneration of processes of the dorsal root ganglion cells.

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Spasov, A. A., and Vadim A. Kosolapov. "THE APPLICATION OF MG-L-ASPARAGINATE AND COMBINATIONS OF MG SALTS WITH VITAMIN B6 IN MEDICINE." Medical Journal of the Russian Federation 23, no. 2 (2017): 89–95. http://dx.doi.org/10.18821/0869-2106-2017-23-2-89-95.

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The magnesium is one of the most important microelements, a universal regulator of biochemical and physiological processes. This microelement is a co-factor of enzymes and participates in energetic, plastic and electrolyte metabolism, in regulation of cell growth, synthesis of protein, etc. In many countries the magnesium deficiency is a burning problem. The medications of non-organic and organic salts of magnesium are used for supplying it. The efficient medications are such asparaginic salts of magnesium as magnesium DL-asparaginate, potassium and magnesium L-asparaginate and magnesium L-asp

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