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Doseděl, Martin, Eduard Jirkovský, Kateřina Macáková, Lenka Krčmová, Lenka Javorská, Jana Pourová, Laura Mercolini, Fernando Remião, Lucie Nováková, and Přemysl Mladěnka. "Vitamin C—Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination." Nutrients 13, no. 2 (February 13, 2021): 615. http://dx.doi.org/10.3390/nu13020615.
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Vitamin C (L-ascorbic acid) has been known as an antioxidant for most people. However, its physiological role is much larger and encompasses very different processes ranging from facilitation of iron absorption through involvement in hormones and carnitine synthesis for important roles in epigenetic processes. Contrarily, high doses act as a pro-oxidant than an anti-oxidant. This may also be the reason why plasma levels are meticulously regulated on the level of absorption and excretion in the kidney. Interestingly, most cells contain vitamin C in millimolar concentrations, which is much higher than its plasma concentrations, and compared to other vitamins. The role of vitamin C is well demonstrated by miscellaneous symptoms of its absence—scurvy. The only clinically well-documented indication for vitamin C is scurvy. The effects of vitamin C administration on cancer, cardiovascular diseases, and infections are rather minor or even debatable in the general population. Vitamin C is relatively safe, but caution should be given to the administration of high doses, which can cause overt side effects in some susceptible patients (e.g., oxalate renal stones). Lastly, analytical methods for its determination with advantages and pitfalls are also discussed in this review.
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Nikolaidis, Michalis G., Chad M. Kerksick, Manfred Lamprecht, and Steven R. McAnulty. "Does Vitamin C and E Supplementation Impair the Favorable Adaptations of Regular Exercise?" Oxidative Medicine and Cellular Longevity 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/707941.
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The detrimental outcomes associated with unregulated and excessive production of free radicals remains a physiological concern that has implications to health, medicine and performance. Available evidence suggests that physiological adaptations to exercise training can enhance the body’s ability to quench free radicals and circumstantial evidence exists to suggest that key vitamins and nutrients may provide additional support to mitigate the untoward effects associated with increased free radical production. However, controversy has risen regarding the potential outcomes associated with vitamins C and E, two popular antioxidant nutrients. Recent evidence has been put forth suggesting that exogenous administration of these antioxidants may be harmful to performance making interpretations regarding the efficacy of antioxidants challenging. The available studies that employed both animal and human models provided conflicting outcomes regarding the efficacy of vitamin C and E supplementation, at least partly due to methodological differences in assessing oxidative stress and training adaptations. Based on the contradictory evidence regarding the effects of higher intakes of vitamin C and/or E on exercise performance and redox homeostasis, a permanent intake of non-physiological dosages of vitamin C and/or E cannot be recommended to healthy, exercising individuals.
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Dawood, Tamara N. "Effect of vitamin C and/or vitamin B complex intake on some productive, physiological and reproductive traits in the female rabbits." Iraqi Journal of Veterinary Medicine 39, no. 1 (June 4, 2015): 8–15. http://dx.doi.org/10.30539/iraqijvm.v39i1.188.
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The aim of this work was to establish the vital role of using vitamin B complex and/or vitamin C in the reproduction. Twenty female rabbits were used and they were divided randomly into four equal groups, all animals were fed 100 g of concentrate pellets diet/ head. The first group was offered drinking water free of vitamins, (control group), second group was supplied with water containing vitamin C (40 mg/ 100ml water/ head), third group was supplied with water containing vitamin B complex (0.5 ml/100ml/head), and fourth group was water supplied containing 20 mg of vitamin C and 0.25 ml of vitamin B complex/100 ml water/head. At the beginning of the experiment, male rabbits were introduced to the females for mating for one hour at morning daily for two weeks before the food and water were supplied. The results revealed that, body weight of all groups increased progressively with age. The treated groups gained insignificantly more than the control group, the second and fourth group showed higher but insignificant. In second and third group caused significant increase in PCV, Hb, WBCs, lymphocyte percentage and decrease in neutrophil, monocyte and eosinophil percentages compared with the control group. However, blood glucose and serum cholesterol levels were significantly decreased (P<0.05) in second and fourth group when compared with first group. While vitamins groups caused insignificant increase in alkaline phosphatase activity enzyme. However, the treated groups showed significantly higher fertility rate and reproductive efficiency ratio compared with the control group and numerically higher in prolificacy ratio (%). But third and fourth group showed better prolificacy and reproductive efficiency ratio than the second group
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Schümann. "Interactions Between Drugs and Vitamins at Advanced Age." International Journal for Vitamin and Nutrition Research 69, no. 3 (May 1, 1999): 173–78. http://dx.doi.org/10.1024/0300-9831.69.3.173.
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Drug consumption increases at advanced age due to increased morbidity. At the same time the state of repletion is reduced for several vitamins. Physiological and kinetic alterations in the elderly are reviewed in order to analyse possible interrelations between these two phenomena. At high age the status of all vitamins is compromised by reduced food intake. Decreased active intestinal transport and an increased propensity for atrophic gastritis may reduce the absorption of vitamins A, B1, folate and B12. Decreased exposure to sunlight and reduced cutaneous synthesis impair the vitamin D status. Studies on the state of vitamin repletion in hospital patients indicate a specific response of vitamins A, B1, B6 and C to drug administration at advanced age. Reduced food intake in the elderly is further compromised by drugs that impair appetite and absorption. Anticonvulsives and other drugs that induce hepatic microsomal enzymes accelerate vitamin D metabolism and aggravate postmenopausal osteoporosis. Acid inhibiting agents increase achlorhydria and reduce vitamin B12 absorption. Renal clearance of acidic drugs such as acetylsalicylic acid and barbituric acid, which is impaired at high age, is further reduced by high doses of vitamin C. Vitamin B6 reduces the therapeutic effect of L-dopa. When recognised, the negative effects of drug-vitamin interactions can be compensated by adequate vitamin supplementation and by adaptation of drug dosing.
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Ajakaiye, Joachim Joseph, Alcides Perez-Bello, and Angel Mollineda-Trujillo. "Impact of Vitamins C and E Dietary Supplementation on Leukocyte Profile of Layer Hens Exposed to High Ambient Temperature and Humidity." Acta Veterinaria Brno 79, no. 3 (2010): 377–83. http://dx.doi.org/10.2754/avb201079030377.
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A 30-day experiment involving 720 White Leghorn layer hens was carried out to evaluate the effects of vitamins C and E on leukocyte and heterophil/lymphocytes ratios of the layer hens during the natural summer conditions. The birds were divided into 4 groups, one control with basal diet and three experimental with diet supplemented with vitamin C, vitamin E, or combination of both vitamins. Each group was divided into 4 subgroups. Exposure of layer hens to 31 ± 3 °C and 33 ± 0 °C ambient temperature and 84.6% and 81.5% relative humidity during the experiment caused an increase in the value of temperature humidity index of 15.5 above the threshold value of 70 established for this species. Total white blood cells, lymphocytes, and eosinophil levels were significantly (p < 0.001) higher in all treated groups compared to control. Similarly, heterophil/lymphocyte ratios of 0.51, 0.52, and 0.50 for groups with diet supplemented with vitamin C, vitamin E and vitamins C + E, respectively, were significantly (p < 0.001) lower compared to 0.59 recorded in the control group. However, heterophil, basophil and monocyte values were significantly (p < 0.001) higher in the control group compared to all treated groups. The results of the present study showed that dietary supplementation of vitamins C and E, or their combination, reduces the harmful effect of high ambient temperature and humidity on the leukocyte indicators of exposed layer hens, thereby alleviating the stress imposed on their thermoregulatory mechanism and physiological status.
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Sathler, Plínio, André Lourenço, Max Saito, Ana Arêas, Carlos Rodrigues, Lúcio Cabral, Helena Castro, and Hye Kang. "The antihemostatic profile of vitamin C: Mechanisms that underlie the technical application of a physiological molecule." Archives of Biological Sciences 68, no. 2 (2016): 325–31. http://dx.doi.org/10.2298/abs150413024s.
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The potential of antioxidants as tools for lowering the incidence of diseases, including cardiovascular events, is of growing interest. Some antioxidants (e.g. vitamin E and acetyl-salicylic acid) have been described as effective on cardiovascular diseases with mechanisms that differ from other scavenging agents. Currently, vitamin C is used to open occluded long-term central venous catheters, which avoids the process of reinserting a new one and injuring the patient. In this work, we investigated the vitamin C antihemostatic profile by evaluating its effects on the coagulation process. We used different assays, including prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (TT) and ancrod time tests. We also examined the overall pH disturbance caused by vitamin C at different concentrations and its effect on the thrombin-initiated fibrin polymerization assay. Our results revealed a significant anticoagulant activity of vitamin C at high plasma concentrations (surpassing the normal 100 ?mol/L ratio) in a cell-independent mechanism. Our results suggest that vitamin C may affect blood coagulation by a direct impairment of fibrin assembly and further formation of a cohesive clot microstructure. This study supports the literature that points to the antihemostatic ability of antioxidant agents, and clarifies the mechanism of vitamin C in opening occluded long-term central venous catheters.
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Zakić, Tamara, Marta Budnar, Anđelika Kalezić, Aleksandra Korać, Aleksandra Janković, and Bato Korać. "Vitamin C biochemistry: From scurvy to COVID-19 treatment." Hrana i ishrana 61, no. 2 (2020): 59–70. http://dx.doi.org/10.5937/hraish2002059z.
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The story of vitamin C (L-ascorbic acid) as an antioxidant and a cofactor in numerous biochemical reactions is a part of its long history and it is well known today. However, many questions of its mechanism of action and the benefits that it has on human health are still emerging. This applies not only to the recommended doses but also to the route of its administration. Besides, there are numerous questions about the therapeutic efficacy of vitamin C in various human (infectious) diseases, as well as its immune system function and antiviral potential. The fact that vitamin C can act as a reductant (antioxidant) and a prooxidant further emphasizes its oxidation-reduction (redox) potential in real physiological conditions. Today, the question of the intravenous administration of vitamin C effect in patients with SARS-CoV-2 requires special attention. This review aims to showcase known facts about vitamin C and its mechanisms of action to better understand the current new challenges related to vitamin C.
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Pavlovic, Voja, and M. Sarac. "A short overview of vitamin C and selected cells of the immune system." Open Medicine 6, no. 1 (February 1, 2011): 1–10. http://dx.doi.org/10.2478/s11536-010-0066-x.
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AbstractVitamin C (ascorbic acid) is an essential water-soluble nutrient that primarily exerts its effect on a host defense mechanisms and immune homeostasis and is the most important physiological antioxidant. Stable intake of vitamin C is essential for life in humans because the body does not synthesize it. Even the numerous studies have demonstrated that vitamin C supplementation stimulates the immune system, prevents DNA damage and significantly decreases the risk of a wide range of pathologies; the potential protective mechanisms are still largely unknown. This review summarizes the recently known facts about the role of vitamin C on the selected cells of the immune system and potential molecular mechanisms involved. Further, in this review, many new data about the positive effects of vitamin C on the immune system, potential toxicological effects, vitamin C supplementation in disease development, as well as some proposed mechanisms of vitamin C activity, are discussed.
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Hemilä, Harri. "Vitamin C intake and susceptibility to the common cold." British Journal of Nutrition 77, no. 1 (January 1997): 59–72. http://dx.doi.org/10.1017/s0007114500002889.
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Although the role of vitamin C in common cold incidence had been studied extensively, the level of vitamin C intake has not been unequivocally shown to affect the incidence of colds. In the present study the six largest vitamin C supplementation (≥ 1 g/d) studies, including over 5000 episodes in all, have been analysed, and it is shown that common cold incidence is not reduced in the vitamin C-supplemented groups compared with the placebo groups (pooled rate ratio (RR) 0·99; 95% CI 0·93, 1·04). Consequently these six major studies give no evidence that high-dose vitamin C supplementation decreases common cold incidence in ordinary people. Nevertheless, the analysis was continued with the hypothesis that vitamin C intake may affect common cold susceptibility in specific groups of people. It was assumed that the potential effect of supplementation might be most conspicuous in subjects with low dietary vitamin C intake. The average vitamin C intake has been rather low in the UK and plasma vitamin C concentrations are in general lower in males than in females. In four studies with British females vitamin C supplementation had no marked effect on common cold incidence (pooled RR 0·95; 95% CI 0·86, 1·04). However, in four studies with British male schoolchildren and students a statistically highly significant reduction in common cold incidence was found in groups supplemented with vitamin C (pooled RR 0·70; 95% CI 0·60, 0·81). Thus, these studies with British males indicate that vitamin C intake has physiological effects on susceptibility to common cold infections, although the effect seems quantitatively meaningful only in limited groups of people and is not very large.
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Blaken, C., M. J. Allen, A. H. Stewart, and A. M. Mackenzie. "The effect of pre-weaning mixing and vitamin C supplementation on piglet performance." Proceedings of the British Society of Animal Science 2003 (2003): 94. http://dx.doi.org/10.1017/s1752756200012539.
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It is well established that the weaning process is one of the most stressful periods for a piglet, which can alter its immune function and performance. Pigs have no specified dietary requirement for vitamin C with it being provided via colostrum and endogenous production. However, during stressful periods, physiological requirements increase, and supplementation may be required. The objective of this study was to investigate the effects of vitamin C supplementation in high and low stress weaning systems on performance and immune function of weaner pigs.
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Abioja, M. O., O. A. Osinowo, O. F. Smith, and Daisy Eruvbetine. "Physiological and haematological responses of broiler chickens offered cold water and vitamin C during hot-dry season." Nigerian Journal of Animal Production 40, no. 1 (December 28, 2020): 24–36. http://dx.doi.org/10.51791/njap.v40i1.611.
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The effects of cold water and vitamin C on broilers’ rectal temperature (RT), respiratory rate (RR) and haematological parameters were evaluated during dry season. Two hundred and sixteen 4-week-old Anak 2000 broilers fed ad libitum were offered either water at ambient temperature (29.5oC; ORD) or cold water (8.0oC; COLD) to which either 0 (-C) or 500 mg vitamin C per litre water (+C) was added to give four treatment groups (ORD-C, ORD+C, COLD-C and COLD+C) from week 5 to 8 of age. There were 3 replicates with 18 birds per replicate. RT and RR were taken for three days weekly at 16.00 h. Blood was sampled weekly for haematological, plasma biochemical and triiodothyronine analyses. Data on RT, RR, packed cell volume (PCV), red blood cell (RBC), haemoglobin concentration (Hb), mean corpuscular haemoglobin concentration (MCHC), mean corpuscular haemoglobin (MCH), mean corpuscular volume (MCV), white blood cell (WBC), heterophil (HET), lymphocyte (LYM), eosinophil (EOS), monocyte (MON), heterophil:lymphocyte ratio (H:L), plasma K+, Na+, glucose (GLU), protein (PRO) and tri-iodothyronine (T3) were subjected to ANOVA using least squares] method. Water temperature had significant (P<0.01) effect on RT and RR. Cold water lowered RT and RR of the birds compared with water at ambient temperature. Similarly, vitamin C in drinking water caused decrease in RT (P<0.001) and RR (P<0.01) compared to ordinary water. Water temperature had no significant (P>0.05) effect on MCHC, MCH, MCV, LMY, EOS, plasma K+, Na+, GLU, PRO and T3. But cold water significantly lowered MON (P<0.05) and increased PCV (P<0.001), RBC (P<0.001),Hb (P<0.001), WBC (P<0.001), HET (P<0.01) and H: L (P<0.05) when compared with water at ambient temperature. Addition of vitamin C significantly increased LYM (P<0.05) and H:L (P<0.05) but decreased HET (P<0.05) when compared with birds that received no vitamin C. Vitamin C had no significant (P>0.05) effect on PCV, RBC, Hb, WBC, MCHC, MCH, MCV, plasma K+, Na+, GLU, PRO and T3. There were significant (P<0.01) interactions between water temperature and vitamin C on HET, LYM and H: L. Broiler chickens offered ORD+C had significantly lower HET and H: L than those offered ORD-C, COLD-C and COLD+C. However, the LYM was highest in ORD+C birds. High HET and H:L, and low LYM are indicators of heat stress in poultry. In conclusion, cold water and vitamin C were effective in reducing broilers’ RT and RR in the afternoon during hot-dry season. Either of the two may improve the well-being of broilers during dry season.
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Gaddafi, S., M. G. Garba, M. Abdulrashid, D. Zahradden, O. M. Daudou, and G. T. Iyeghe-Erakpotobor. "Effect of antioxidant supplements on testicular histo-morphology in adult male guinea pigs (Cavia porcellus)." Nigerian Journal of Animal Production 47, no. 5 (December 31, 2020): 29–40. http://dx.doi.org/10.51791/njap.v47i5.1272.
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The study was carried out to evaluate the biopotency of antioxidant supplements on physiological, testicular and oxidative biomarkers in adult male guinea pigs (Cavia porcellus). A total of 60 adult male guinea pigs of three months of age with an average body weight of 500±20g were randomly allocated into three dietary treatment groups of vitamin C, vitamin E and selenium and each comprised four varying levels with five animals per group in a completely randomized design (CRD). Feed and water were provided ad-libitum. The testicular morphology showed a significant (P<0.05) difference in weight of right testis, weight of left testis, paired testis weight, right testis width, testis volume, testis density, right testis length and left testis length of guinea pig supplemented varying dosage of vitamin C, E and Selenium. microphotograph indicated considerable changes in seminiferous tubules density, size, and other morphological characteristics, also intertubular space, basement membrane, leydigs cells and spermatogonia of the guinea pigs supplemented varying dosage of vitamin C, E and Selenium revealed considerable changes. The supplementation of adult male guinea pigs diets with 200 mg vitamin C had the highest values of testicular morphometric followed by 15 mg vitamin E group and 0.3 mg of selenium. Similarly, considerable histo-architectural changes in seminiferous tubules and interstitial cells size and shape occurred in guinea pigs supplemented 200, 15 and 0.3 mg per kg diet vitamin C, E and selenium respectively. Therefore, supplementation of vitamin C, E and Selenium has a profound effect on testicular histo-morphology of adult male guinea pigs. L'étude a été réalisée pour évaluer la biopotence des suppléments antioxydants sur les biomarqueurs physiologiques, testiculaires et oxydatifs chez les cobayes mâles adultes (Caviaporcellus). Un total de 60 cobayes mâles adultes de trois mois avec un poids corporel moyen de 500 ± 20 g ont été répartis au hasard dans trois groupes de traitement diététique de vitamine C, vitamine E et sélénium et chacun comprenait quatre niveaux variables avec cinq animaux par groupe en une conception complètement aléatoire. L'alimentation et l'eau étaient fournies ad libitum. La morphologie testiculaire a montré une différence significative (P <0.05) du poids du testicule droit, du poids du testicule gauche, du poids du testicule apparié, de la largeur du testicule droit, du volume du testicule, de la densité du testicule, de la longueur du testicule droit et de la longueur du testicule gauche du cobaye supplémenté en doses variables de vitamine C, E et sélénium. La microphotographie a indiqué des changements considérables dans la densité, la taille et d'autres caractéristiques morphologiques des tubules séminifères, ainsi que l'espace intertubulaire, la membrane basale, les cellules de 'leydigs' et la spermatogonie des cobayes complétés par des doses variables de vitamine C, E et de sélénium ont révélé des changements considérables. La supplémentation des régimes alimentaires de cobayes mâles adultes avec 200 mg de vitamine C avait les valeurs les plus élevées de morphométrie testiculaire suivie par 15 mg de groupe de vitamine E et 0.3 mg de sélénium. De même, des changements histoarchitecturaux considérables de la taille et de la forme des tubules séminifères et des cellules interstitielles se sont produits chez les cobayes ayant reçu respectivement 200, 15 et 0.3 mg par kg de vitamine C, E et de sélénium. Par conséquent, la supplémentation en vitamine C, E et en sélénium a un effet profond sur l'histomorphologie testiculaire des cobayes males adultes.
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Ikaraoha, Ikechukwu Chidiebere, Nkeiruka Chigaekwu Mbadiwe, John Ibhagbemien Anetor, Constance Nnedimma Nwadike, and Isreal Ojareva Oforofuo. "Maternal to fetal transfer of vitamin C and vitamin E: effect on birth outcome in a Nigerian population." Asian Journal of Medical Sciences 7, no. 4 (July 4, 2016): 49–54. http://dx.doi.org/10.3126/ajms.v7i4.14372.
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Background: New evidence suggests that excessive production of reactive oxygen species give rise to oxidative stress which could impair fetal growth. Antioxidant vitamin C and vitamin E have vital role in physiological process of pregnancy and health of the developing fetus.Aims and Objectives: To determine the concentrations of vitamin C and vitamin E in pair-matched maternal and cord serum of newborns and to determine the relationship between maternal/cord serum vitamin C and vitamin E at delivery and birth outcomes.Materials and Methods: A total of 209 maternal and cord blood samples were collected during delivery for serum vitamin C and E determination. Birth outcomes; birth weight, birth length, head circumference, and Apgar score were determined.Result: Newborns had significantly higher levels of vitamin C as compared to their mothers, but had non-significant lower level of vitamin E. Levels of vitamin C and E in both maternal and cord serum were positively correlated to birth weight, birth length, head circumference and Apgar score.Conclusion: Maternal vitamin C and E had significant effects on birth outcomes. A positive correlation of vitamin C and E indicates that their status in mother does influence newborns status.Asian Journal of Medical Sciences Vol.7(4) 2016 49-54
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Tack, Christopher, Faye Shorthouse, and Lindsy Kass. "The Physiological Mechanisms of Effect of Vitamins and Amino Acids on Tendon and Muscle Healing: A Systematic Review." International Journal of Sport Nutrition and Exercise Metabolism 28, no. 3 (May 1, 2018): 294–311. http://dx.doi.org/10.1123/ijsnem.2017-0267.
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Aims/Objectives: To evaluate the current literature via systematic review to ascertain whether amino acids/vitamins provide any influence on musculotendinous healing and if so, by which physiological mechanisms. Methods: EBSCO, PubMed, ScienceDirect, Embase Classic/Embase, and MEDLINE were searched using terms including “vitamins,” “amino acids,” “healing,” “muscle,” and “tendon.” The primary search had 479 citations, of which 466 were excluded predominantly due to nonrandomized design. Randomized human and animal studies investigating all supplement types/forms of administration were included. Critical appraisal of internal validity was assessed using the Cochrane risk of Bias Tool or the Systematic Review Centre for Laboratory Animal Experimentation Risk of Bias Tool for human and animal studies, respectively. Two reviewers performed duel data extraction. Results: Twelve studies met criteria for inclusion: eight examined tendon healing and four examined muscle healing. All studies used animal models, except two human trials using a combined integrator. Narrative synthesis was performed via content analysis of demonstrated statistically significant effects and thematic analysis of proposed physiological mechanisms of intervention. Vitamin C/taurine demonstrated indirect effects on tendon healing through antioxidant activity. Vitamin A/glycine showed direct effects on extracellular matrix tissue synthesis. Vitamin E shows an antiproliferative influence on collagen deposition. Leucine directly influences signaling pathways to promote muscle protein synthesis. Discussion: Preliminary evidence exists, demonstrating that vitamins and amino acids may facilitate multilevel changes in musculotendinous healing; however, recommendations on clinical utility should be made with caution. All animal studies and one human study showed high risk of bias with moderate interobserver agreement (k = 0.46). Currently, there is limited evidence to support the use of vitamins and amino acids for musculotendinous injury. Both high-quality animal experimentation of the proposed mechanisms confirming the physiological influence of supplementation and human studies evaluating effects on tissue morphology and biochemistry are required before practical application.
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Zhang, Z.-W. "Effect of physiological concentrations of vitamin C on gastric cancer cells and Helicobacter pylori." Gut 50, no. 2 (February 1, 2002): 165–69. http://dx.doi.org/10.1136/gut.50.2.165.
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Abreu, Janessa Sampaio de, and Elisabeth Criscuolo Urbinati. "Physiological responses of matrinxã (Brycon amazonicus) fed different levels of vitamin C and submitted to air exposure." Acta Amazonica 36, no. 4 (December 2006): 519–24. http://dx.doi.org/10.1590/s0044-59672006000400013.
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The role of vitamin C on physiological responses of matrinxã (Brycon amazonicus) submitted to air exposure was analyzed. Nine hundred fish (70.15 g) were distributed in fifteen 500 l boxes (60 fish.box-1) and fed five rations (treatments): Control (no vitamin C); T100 (100 mg); T200 (200 mg); T400 (400 mg) and T800 (800 mg of vitamin C kg.ration-1). Each ration was offered to fish of three boxes during 60 days before the stress challenge that consisted of exposing fish to air for two minutes. Samplings were carried out for 5, 15, 30 and 60 minutes after the air exposure. Blood was collected for glucose, cortisol, total protein, sodium, chloride, hematocrit, hemoglobin determination, and white and red cell count. Liver was removed for hepatosomatic index (HSI) calculation and glycogen determination. Vitamin C did not affect the levels of cortisol, chloride, total protein, hemoglobin, leukocytes, hepatic glycogen or HSI in air exposed fish. Blood glucose levels elevation observed 60 minutes after the challenge did not depend on the levels of vitamin C, nor did the drop in serum sodium levels verified 60 minutes after stressor. In general, hematocrit did not change by effect of vitamin C but it was lower at 15 and 30 minutes after the challenge. The number of erythrocytes decreased in fish after 5 minute sampling in all treatments, especially at 30 and 60 minutes. The air exposure evoked alterations in stress indicators of matrinxã, and the vitamin C did not alter the responses.
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Reboul, Emmanuelle, Sinay Thap, Franck Tourniaire, Marc André, Christine Juhel, Sophie Morange, Marie-Josèphe Amiot, Denis Lairon, and Patrick Borel. "Differential effect of dietary antioxidant classes (carotenoids, polyphenols, vitamins C and E) on lutein absorption." British Journal of Nutrition 97, no. 3 (March 2007): 440–46. http://dx.doi.org/10.1017/s0007114507352604.
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Lutein is assumed to protect the human retina from blue light and oxidative stress and diminish the incidence of age-related macular degeneration. This antioxidant is commonly ingested with other dietary antioxidants. The aim of the present study was to assess whether the main dietary antioxidants, i.e. carotenoids, polyphenols and vitamins C and E, affect lutein absorption. We measured the effect of adding a mixture of antioxidants (500 mg vitamin C, 67 mg (100 IU) vitamin E and 1 g polyphenols) to a lutein-containing meal (18 mg) on the postprandial lutein response in the chylomicron-rich fraction in eight healthy men. Lutein response was weakest ( − 23 %;P = 0·07) after ingestion of the meal containing antioxidants (21·9 (sem4·6)v.28·4 (sem7·2) nmol × h/l). To assess the effect of each class of antioxidants and potential interactions, we subsequently evaluated the effect of various combinations of antioxidants on lutein uptake by human intestinal Caco-2 TC-7 cells. A full factorial design showed that both a mixture of polyphenols (gallic acid, caffeic acid, (+)-catechin and naringenin) and a mixture of carotenoids (lycopene plus β-carotene) significantly (P < 0·05) impaired lutein uptake by ( − 10 to − 30 %), while vitamins C and E had no significant effect. Subsequent experiments showed that the aglycone flavanone naringenin was the only polyphenol responsible for the effect of the polyphenol mixture, and that the carotenoid effect was not carotenoid species-dependent. Taken together, the present results suggest that lutein absorption is not markedly affected by physiological concentrations of vitamins C and E but can be impaired by carotenoids and naringenin.
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Al-Kaisy, Wifak, and Sahar Mahadi. "Response of Pea (Pisum sativum L.) to foliar application of ABA and vitamin C and interaction of them on some physiological characters of plant." Al-Mustansiriyah Journal of Science 29, no. 1 (October 31, 2018): 32. http://dx.doi.org/10.23851/mjs.v29i1.76.
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The field experimental was conducted during the growth winter season of 2016-2017 at Botanical garden of Department of Biology, College of Education for Pure Science (Ibn Al-Haitham), University of Baghdad. The experimental aimed to study the effect of different of foliar application (0, 10, 20) mg.L-1 and vitamin C (0, 50, 100, 150) mg.L-1 and interaction of them on some physiological characters of pea (Pisum sativum L.). The results showed that ABA increased the proline and increased the vitamin C content at 10 mg.L-1. The vitamin C increased absolute growth rate (AGR), biomass duration, proline, vitamin C content compared with control plants.
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Liu, Minmin, Hitoshi Ohtani, Wanding Zhou, Andreas Due Ørskov, Jessica Charlet, Yang W. Zhang, Hui Shen, et al. "Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine." Proceedings of the National Academy of Sciences 113, no. 37 (August 29, 2016): 10238–44. http://dx.doi.org/10.1073/pnas.1612262113.
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Vitamin C deficiency is found in patients with cancer and might complicate various therapy paradigms. Here we show how this deficiency may influence the use of DNA methyltransferase inhibitors (DNMTis) for treatment of hematological neoplasias. In vitro, when vitamin C is added at physiological levels to low doses of the DNMTi 5-aza-2′-deoxycytidine (5-aza-CdR), there is a synergistic inhibition of cancer-cell proliferation and increased apoptosis. These effects are associated with enhanced immune signals including increased expression of bidirectionally transcribed endogenous retrovirus (ERV) transcripts, increased cytosolic dsRNA, and activation of an IFN-inducing cellular response. This synergistic effect is likely the result of both passive DNA demethylation by DNMTi and active conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) by ten–eleven translocation (TET) enzymes at LTR regions of ERVs, because vitamin C acts as a cofactor for TET proteins. In addition, TET2 knockout reduces the synergy between the two compounds. Furthermore, we show that many patients with hematological neoplasia are markedly vitamin C deficient. Thus, our data suggest that correction of vitamin C deficiency in patients with hematological and other cancers may improve responses to epigenetic therapy with DNMTis.
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Hamada, A., A. Metwally, and R. El-Shazoly. "Amelioration of extreme temperature stress in alfalfa seedlings by vitamin C and vitamin B6." Acta Agronomica Hungarica 60, no. 1 (March 1, 2012): 57–70. http://dx.doi.org/10.1556/aagr.60.2012.1.7.
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Concerns about the vulnerability of agricultural production to climate change are increasing. The establishment of seedlings at early growth stages of crop plants, one of the most important determinants of high yield, is severely affected by extreme temperatures. Therefore, efforts must be made to achieve high germination rate and vigorous early growth under extreme temperature conditions.Alfalfa is a perennial forage crop with high yield, good quality and high protein content, but is frequently exposed to extreme temperature conditions. The primary purpose of this investigation was to test the hypothesis that L-ascorbic acid (AsA) and pyridoxine (B6) pretreatment can completely or partially alleviate the effect of extreme temperature stress on seed germination and other physiological activities of alfalfa seedlings. Such treatment could be of importance for the establishment of alfalfa seedlings under temperature conditions colder or hotter than the optimum.Several parameters were studied in alfalfa seedlings primed before germination with 50 ppm ascorbic acid or 50 ppm pyridoxine for 6 h and then subjected to various temperatures (10, 15, 20, 25, 30, 35 and 40°C) for 7 days.The germination percentage of alfalfa seeds was negatively affected by extreme temperature. The vitamin treatments failed to alleviate the depressive effect of extreme temperature stress on seed germination. Extreme temperature also induced a reduction in the growth, total water content and respiration rate of alfalfa seedlings. Seed soaking in vitamins modified the stress-induced changes in respiration rate and growth criteria. Temperatures above or below the optimum stimulated the accumulation of soluble carbohydrates in alfalfa seedlings. Treatment with AsA or B6 partially or completely retarded the stimulatory effects of extreme temperature on soluble carbohydrate accumulation in the seedlings except in the case of 40 °C, where a significant stimulation was detected. However, extreme temperature stress and its interactive effects with AsA or B6 induced an inhibitory effect on the accumulation of free amino acids and soluble proteins in the test seedlings.
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Otocka-Kmiecik, Aneta, and Aleksandra Król. "The Role of Vitamin C in Two Distinct Physiological States: Physical Activity and Sleep." Nutrients 12, no. 12 (December 21, 2020): 3908. http://dx.doi.org/10.3390/nu12123908.
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This paper is a literature overview of the complex relationship between vitamin C and two opposing physiological states, physical activity and sleep. The evidence suggests a clinically important bidirectional association between these two phenomena mediated by different physiological mechanisms. With this in mind, and knowing that both states share a connection with oxidative stress, we discuss the existing body of evidence to answer the question of whether vitamin C supplementation can be beneficial in the context of sleep health and key aspects of physical activity, such as performance, metabolic changes, and antioxidant function. We analyze the effect of ascorbic acid on the main sleep components, sleep duration and quality, focusing on the most common disorders: insomnia, obstructive sleep apnea, and restless legs syndrome. Deeper understanding of those interactions has implications for both public health and clinical practice.
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Pedersen, Bente Klarlund, Helle Bruunsgaard, Marianne Jensen, Karen Krzywkowski, and Kenneth Ostrowski. "Exercise and immune function: effect of ageing and nutrition." Proceedings of the Nutrition Society 58, no. 3 (August 1999): 733–42. http://dx.doi.org/10.1017/s0029665199000968.
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Strenuous exercise is followed by lymphopenia, neutrophilia, impaired natural immunity, decreased lymphocyte proliferative responses to mitogens, a low level of secretory immunoglobulin A in saliva, but high circulating levels of pro- and anti-inflammatory cytokines. These exercise-induced immune changes may provide the physiological basis of altered resistance to infections. The mechanisms underlying exercise-induced immune changes are multifactorial and include neuroendocrinological and metabolic mechanisms. Nutritional supplementation with glutamine abolishes the exercise-induced decline in plasma glutamine, but does not influence post-exercise immune impairment. However, carbohydrate loading diminishes most exercise effects of cytokines, lymphocyte and neutrophils. The diminished neutrophilia and elastase (EC3.4.21.37) responses to eccentric exercise in elderly subjects were enhanced to levels comparable with those of young subjects by fish oil or vitamin E supplements. However, although vitamin C supplementation may diminish the risk of contracting an infection after strenuous exercise, it is not obvious that this effect is linked to an effect of vitamin C on exercise-induced immune changes. In conclusion, it is premature to make recommendations regarding nutritional supplementation to avoid post-exercise impairment of the immune system.
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Diab, Abdel Aziz A., Mansour H. Zahra, Mai S. Attia, and Ahmed M. Shehata. "Physiological and biochemical studies on the protective effect of Ficus carica leaf extract, vitamin C or their combination on liver toxicity induced by lead acetate in male rats." Biomedical Research and Therapy 5, no. 10 (October 18, 2018): 2733–45. http://dx.doi.org/10.15419/bmrat.v5i10.488.
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Introduction: Lead is an environmental contaminant, which is toxic to organ systems in human and other animals. The present study investigated the possible protective role of Ficus carica leaf extract, vitamin C or the combined treatment in lead acetate-induced hepatotoxicity.
Methods: One hundred and twenty-six adult male albino rats were divided into seven groups (n = 18). G1 (control group) received distilled water. G2 (lead acetate group) received lead acetate at a daily dose of 20 mg/kg body weight by gastric gavage. G3 (Ficus carica group) received Ficus carica leaves extract at a daily dose of 200 mg/kg body weight by gastric gavage. G4 (Ficus and lead group) received Ficus carica leaves extract followed by lead acetate after 20 minutes. G5 (vitamin C group) received vitamin C at a daily dose of 200 mg/kg body weight by gastric gavage, G6 (vitamin c and lead group) received vitamin C followed by lead acetate after 20 minutes. And, G7 (Ficus, vitamin C, and lead group) received Ficus carica leaves extract and vitamin C followed by lead acetate after 20 minutes. The treatment extended for six weeks, blood and specimens were collected at a 2-week interval. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total protein (TP), direct bilirubin (DB), lipid peroxidation biomarker (Malondialdehyde (MDA)), antioxidants enzymes (Superoxide dismutase (SOD) and reduced glutathione (GSH)) in liver tissue and histopathological changes in liver were investigated.
Results: Lead acetate caused significant increases in AST, ALT, ALP, DB and MDA levels. In addition, TP and level of SOD and GSH significantly decreased compared to the control group. The pre-treatment with the combination of Ficus carica and vitamin C improved liver parameters, the level of antioxidant enzymes as well as histopathological changes.
Conclusion: The combination of Ficus carica leaf extract and vitamin C had a remarkable protective action against lead acetate induced- oxidative damage in rats.
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Peake, Jonathan M. "Vitamin C: Effects of Exercise and Requirements with Training." International Journal of Sport Nutrition and Exercise Metabolism 13, no. 2 (June 2003): 125–51. http://dx.doi.org/10.1123/ijsnem.13.2.125.
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Ascorbic acid or vitamin C is involved in a number of biochemical pathways that are important to exercise metabolism and the health of exercising individuals. This review reports the results of studies investigating the requirement for vitamin C with exercise on the basis of dietary vitamin C intakes, the response to supplementation and alterations in plasma, serum, and leukocyte ascorbic acid concentration following both acute exercise and regular training. The possible physiological significance of changes in ascorbic acid with exercise is also addressed. Exercise generally causes a transient increase in circulating ascorbic acid in the hours following exercise, but a decline below pre-exercise levels occurs in the days after prolonged exercise. These changes could be associated with increased exercise-induced oxidative stress. On the basis of alterations in the concentration of ascorbic acid within the blood, it remains unclear if regular exercise increases the metabolism of vitamin C. However, the similar dietary intakes and responses to supplementation between athletes and nonathletes suggest that regular exercise does not increase the requirement for vitamin C in athletes. Two novel hypotheses are put forward to explain recent findings of attenuated levels of cortisol postexercise following supplementation with high doses of vitamin C.
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Agyemang Duah, Stella, Clarice Silva e. Souza, Zsuzsa Nagy, Zoltán Pék, András Neményi, Hussein G. Daood, Szergej Vinogradov, and Lajos Helyes. "Effect of Water Supply on Physiological Response and Phytonutrient Composition of Chili Peppers." Water 13, no. 9 (May 1, 2021): 1284. http://dx.doi.org/10.3390/w13091284.
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Water supply is a primary contributor to the growth and phytonutrient composition in chili peppers. Several physiological stress factors can influence phytonutrients in chili peppers, resulting in their differential synthesis. Maintaining the right and exact amount of water through a drip system can promote an effective fruit set and crop quality. Four pepper cultivars (‘Hetényi Parázs’; HET, ‘Unikal’; UNIK, ‘Unijol’; UNIJ and ‘Habanero’; HAB) were investigated under different water supply treatments: RF or rain-fed, DI or deficit irrigation, and OWS or optimum water supply. The two-year experiment was carried out in May 2018 and 2019 under open field conditions. Physiological parameters (relative chlorophyll content, chlorophyll fluorescence, and canopy temperature) were measured during the growth stage and phytonutrients (vitamin C, capsaicinoids and carotenoids) analyzed using high-performance liquid chromatography (HPLC) at harvest in September. The study revealed that, due to higher precipitation and rainfall interruption, increased water supply affected physiological response and phytonutrients in the cultivars. HAB under OWS had a lower response during the growth period when compared to HET, UNIK, and UNIJ. As water supply increased, measured individual carotenoid concentration increased in some cultivars. On the other hand, as water supply decreased, vitamin C and capsaicinoids concentration increased. Even though cultivars responded to the water supply treatments differently, HET exhibited a more uniform and stable composition in all treatments.
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TAYEB, Ihsan T., Saeb Younis ABDUL-RAHMAN, and Narin Nidhamaddin SIDEEQ. "Effect of Vitamin C, Red Pepper and Oak Leaves on Physiological and Productive Performance of Quail." Kahramanmaraş Sütçü İmam Üniversitesi Doğa Bilimleri Dergisi 18, no. 2 (December 18, 2015): 1. http://dx.doi.org/10.18016/ksujns.11485.
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Popovic, Ljiljana M., Nebojsa R. Mitic, Dijana Miric, Boban Bisevac, Mirjana Miric, and Brankica Popovic. "Influence of Vitamin C Supplementation on Oxidative Stress and Neutrophil Inflammatory Response in Acute and Regular Exercise." Oxidative Medicine and Cellular Longevity 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/295497.
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Exercise induces a multitude of physiological and biochemical changes in blood affecting its redox status. Tissue damage resulting from exercise induces activation of inflammatory cells followed by the increased activity of myeloperoxidase (MPO) in circulation. Vitamin C readily scavenges free radicals and may thereby prevent oxidative damage of important biological macromolecules. The aim of this study was to examine the effect of vitamin C supplementation on oxidative stress and neutrophil inflammatory response induced by acute and regular exercise. Experiment was conducted on acute exercise group (performing Bruce Treadmill Protocol (BTP)) and regular training group. Markers of lipid peroxidation, malondialdehyde (MDA), MPO activity, and vitamin C status were estimated at rest and after BTP (acute exercise group) and before and after vitamin C supplementation in both groups. Our results showed increased postexercise Asc in serum independently of vitamin supplementation. They also showed that vitamin C can significantly decrease postexercise MDA level in both experimental groups. Increased postexercise MPO activity has been found in both groups and was not affected by vitamin C supplementation. We concluded that vitamin C supplementation can suppress lipid peroxidation process during exercise but cannot affect neutrophil inflammatory response in either exercise group.
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Paciolla, Costantino, Stefania Fortunato, Nunzio Dipierro, Annalisa Paradiso, Silvana De Leonardis, Linda Mastropasqua, and Maria Concetta de Pinto. "Vitamin C in Plants: From Functions to Biofortification." Antioxidants 8, no. 11 (October 29, 2019): 519. http://dx.doi.org/10.3390/antiox8110519.
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Vitamin C (l-ascorbic acid) is an excellent free radical scavenger, not only for its capability to donate reducing equivalents but also for the relative stability of the derived monodehydroascorbate radical. However, vitamin C is not only an antioxidant, since it is also a cofactor for numerous enzymes involved in plant and human metabolism. In humans, vitamin C takes part in various physiological processes, such as iron absorption, collagen synthesis, immune stimulation, and epigenetic regulation. Due to the functional loss of the gene coding for l-gulonolactone oxidase, humans cannot synthesize vitamin C; thus, they principally utilize plant-based foods for their needs. For this reason, increasing the vitamin C content of crops could have helpful effects on human health. To achieve this objective, exhaustive knowledge of the metabolism and functions of vitamin C in plants is needed. In this review, the multiple roles of vitamin C in plant physiology as well as the regulation of its content, through biosynthetic or recycling pathways, are analyzed. Finally, attention is paid to the strategies that have been used to increase the content of vitamin C in crops, emphasizing not only the improvement of nutritional value of the crops but also the acquisition of plant stress resistance.
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Pacier, Callen, and Danik M. Martirosyan. "Vitamin C: optimal dosages, supplementation and use in disease prevention." Functional Foods in Health and Disease 5, no. 3 (March 7, 2015): 89. http://dx.doi.org/10.31989/ffhd.v5i3.174.
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Background: The importance of vitamin C as a way to prevent scurvy has been known for centuries. More recent research on vitamin C has expanded beyond scurvy prevention, providing promising evidence for additional health benefits and clinical applications. This review of scientific literature will evaluate many aspects of vitamin C including deficient versus optimal blood plasma levels, adequate daily amounts necessary to maintain ideal levels, and the safety of higher doses. It will also focus on the importance of vitamin C as a powerful bioactive compound, and its utilization in the prevention and management of different chronic diseases. This review is necessary to express the importance of alternative healthcare methods in both preventative and clinical care. Vitamin C was chosen as a representative of this concept due to its powerful antioxidant capacity, incredibly important physiological implications, and very minimal chance of side-effects. This review focuses on studies involving human participants that address how vitamin C is important for our health.Keywords: Ascorbic acid, deficiency, disease, dose, health, supplementation, vitamin C
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Moor, U., K. Karp, P. Põldma, and M. Starast. "Effect of 1-MCP treatment on apple biochemical content and physiological disorders." Acta Agronomica Hungarica 55, no. 1 (March 1, 2007): 61–70. http://dx.doi.org/10.1556/aagr.55.2007.1.7.
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The research was conducted with the apple ( Malus domestica ) cultivars Krameri Tuviõun and Talvenauding at the Estonian Agricultural University during 2003–2005. The aim was to study the effect of 1-methylcyclopropene (1-MCP) treatment (1 ppm, at room temperature, 24 h) on the biochemical content and physiological disorders of apples and on external quality after 4 months of storage. The apples were stored in a normal atmosphere at 2–5°C and 80–85% RH. In the first storage season 1-MCP treatment did not improve apple quality in general; only the peel background colour of treated apples remained greener. In the second storage season 1-MCP treatment influenced the biochemical content of the apples and improved apple quality: treated fruits were firmer (increase from 4.7 kg/cm 2 to 8.1 kg/cm 2 ) and contained more vitamin C; also, the SSC decreased and the loss of titratable acids was delayed. Consequently fruit spoilage decreased by 30%.
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Jefri, Budi, Bintang YM Sinaga, Parluhutan Siagian, and Putri Chairani Eyanoer. "The Effect of Vitamin C Supplementation on Chest X-Rayimprovementin Pulmonary Tuberculosis Patients During Intensive Phase in Medan." Jurnal Respirologi Indonesia 40, no. 2 (April 30, 2020): 82–87. http://dx.doi.org/10.36497/jri.v40i2.105.
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Backgrounds: Tuberculosis (TB) is still a public health problem in the world.Vitamin C is a water-soluble micronutrient, protects the host from reactive oxygen and reactive nitrogen intermediates generated during mycobacterial infection, involved in the synthesis of collagen, iron transport, and acts as physiological antioxidant. Vitamin C plays role in killing Mycobacterium tuberculosis by fenton reaction. This study was to determine the effect of vitamin C supplementation on chest X-ray (CXR) improvement in pulmonary TB patients during intensive phase.
Methods: This was a quasy experimental study with single blind-randomized controlled trial design. Subjects were divided into 2 groups, first group was pulmonary TB patients treated with anti tuberculosis drugs (ATD) plus vitamin C and the second group was treated with ATD plus placebo. This study was conducted in several public health center in Medan City. The subjects were pulmonary TB patients with positive AFB sputum in intensive phase from December 2017 to May 2018. Data were analized using t-test dependent.
Results: From 80 total subjects, 53 males (66%) and 27 females (34%). After 2 months of treatment, improvements in CXR images were found in the ATD plus vitamin C group, about 21 subjects (52.5%) had no more lesions on CXR, while the same condition was found on 15 subjects (37.5%) in the placebo group.
Conclusion: Vitamin C supplementation in pulmonary TB provided better improvements of CXR images. (J Respir Indo. 2020; 40(2): 82-7)
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Ari Kusuma Putra, I. Gusti Agung Ngurah, I. Gusti Ngurah Sutapa, and I. Gde Antha Kasmawan. "PEMANFAATAN RADIASI GAMMA Co-60 DALAM PEMULIAAN TANAMAN TOMAT (Lycopersicon esculentum L.) DENGAN METODE MUTAGEN FISIK." BULETIN FISIKA 18, no. 1 (February 1, 2017): 12. http://dx.doi.org/10.24843/bf.2017.v18.i01.p03.
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A research on Co-60 gamma radiation effect of induced mutation in physiological growth of tomato plant (Lycopersicon Esculentum L.) has been done. Tomato plant quality can be improved through induced mutation Co-60 gamma radiation. Genetic change could be caused by induced mutation from radioactive material as a human effort. IRPASENA plant with Co-60 gamma radiation source exposed with dosage treatment of 50 Gy, 100 Gy, 150 Gy, 200 Gy and 250 Gy in tomato seeds. The measurement carried out against the physiological growth of plant height, leaves width, amount and weight of tomato fruits at the first week until harvest time. Result shows that the correct radiation dosage for tomato breeding is 100 Gy. Radioactivity concentration in improved tomato fruits after radiation exposure is less than 1.00 Bq/kg. Vitamins content on improved tomato fruits after exposure, particularly on vitamin C is 130.000 mg/kg compared to control fruit that is 70.000 mg/kg, the vitamin B1 also shows increased value (0.63 mg/kg) compared with control fruit (0.496%).
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Bouayed, Jaouad, and Torsten Bohn. "Exogenous Antioxidants—Double-Edged Swords in Cellular Redox State: Health Beneficial Effects at Physiologic Doses versus Deleterious Effects at High Doses." Oxidative Medicine and Cellular Longevity 3, no. 4 (2010): 228–37. http://dx.doi.org/10.4161/oxim.3.4.12858.
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The balance between oxidation and antioxidation is believed to be critical in maintaining healthy biological systems. Under physiological conditions, the human antioxidative defense system including e.g., superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH) and others, allows the elimination of excess reactive oxygen species (ROS) including, among others superoxide anions (O2.-), hydroxyl radicals (OH.), alkoxyl radicals (RO.) and peroxyradicals (ROO.). However, our endogenous antioxidant defense systems are incomplete without exogenous originating reducing compounds such as vitamin C, vitamin E, carotenoids and polyphenols, playing an essential role in many antioxidant mechanisms in living organisms. Therefore, there is continuous demand for exogenous antioxidants in order to prevent oxidative stress, representing a disequilibrium redox state in favor of oxidation. However, high doses of isolated compounds may be toxic, owing to prooxidative effects at high concentrations or their potential to react with beneficial concentrations of ROS normally present at physiological conditions that are required for optimal cellular functioning. This review aims to examine the double-edged effects of dietary originating antioxidants with a focus on the most abundant compounds, especially polyphenols, vitamin C, vitamin E and carotenoids. Different approaches to enrich our body with exogenous antioxidants such as via synthetic antioxidants, diets rich in fruits and vegetables and taking supplements will be reviewed and experimental and epidemiological evidences discussed, highlighting that antioxidants at physiological doses are generally safe, exhibiting interesting health beneficial effects.
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Egwu, Godwin, Gideon Mshelia, Saka Sanni, Patrick Onyeyili, Charles Mshelia, and Nusirat Elelu. "The Effect of Various doses of Vitamin C on some Physiological Parameters in Rabbits Following Xylazine Anaesthesia." Journal of Physiology and Pharmacology Advances 5, no. 5 (2015): 643. http://dx.doi.org/10.5455/jppa.20150508125619.
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Wolters, Hermann, and Hahn. "Effects of 6-Month Multivitamin Supplementation on Serum Concentrations of alpha-Tocopherol, beta-Carotene, and Vitamin C in Healthy Elderly Women." International Journal for Vitamin and Nutrition Research 74, no. 2 (March 1, 2004): 161–68. http://dx.doi.org/10.1024/0300-9831.74.2.161.
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Objective: The aim of this study was to evaluate the effect of supplementation with nutritional doses of antioxidant nutrients on the serum concentrations of ascorbic acid, alpha-tocopherol, and beta-carotene in healthy elderly women. Methods: The study was performed as a randomized placebo-controlled, double-blind trial. Two hundred forty-one free-living, healthy women aged 60 years and older were recruited by newspaper advertisement in Hanover, Germany and its environs. As 21 women dropped out, data of 220 women (aged 60–91 years, median 63 years) were included in this evaluation. Subjects were randomly assigned to receive either a multivitamin/mineral or placebo capsule with identical appearance for six months containing 36 mg vitamin E, 150 mg vitamin C, and 9 mg beta-carotene. Serum concentrations of vitamin C, alpha-tocopherol, and beta-carotene were measured initially and after six months of supplementation. Data were analyzed with the SPSS 10.0 program. Results: Median serum concentrations of alpha-carotene and vitamin E increased significantly in the supplemented group (p = 0.000), whereas no significant modifications were observed in the placebo group. Median vitamin C concentration of the supplemented group did not differ from baseline after intervention, but that of the placebo group was significantly decreased after six months (p = 0.000). In comparison to estimated desirable serum concentrations of > 30 mumol/L vitamin E, 50 mumol/L vitamin C, and > 0.4 mumol/l beta-carotene at baseline, lower concentrations were found in 21.1%, 6.9%, and 1.0% of all subjects, respectively. After supplementation none of the members of the supplemented group had tocopherol concentrations below 30 mumol/L and only one woman of the supplemented group had a serum beta-carotene concentration below 0.4 mumol/L. The change in serum concentrations of vitamin C and E in the supplemented group depended on the status at baseline. Conclusion: A six-month supplementation with physiological doses of antioxidant vitamins improves the blood concentration of these nutrients even in relatively well-nourished elderly women or, as seen for vitamin C, prevents reduction of serum concentrations. Prevalence of suboptimal serum concentrations can be reduced.
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Bozonet, Stephanie M., and Anitra C. Carr. "The Role of Physiological Vitamin C Concentrations on Key Functions of Neutrophils Isolated from Healthy Individuals." Nutrients 11, no. 6 (June 17, 2019): 1363. http://dx.doi.org/10.3390/nu11061363.
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Vitamin C (ascorbate) is important for neutrophil function and immune health. Studies showing improved immune function have primarily used cells from scorbutic animals or from individuals with infectious conditions or immune cell disorders. Few studies have focused on the requirements of neutrophils from healthy adults. Therefore, we have investigated the role of vitamin C, at concentrations equivalent to those obtained in plasma from oral intakes (i.e., 50–200 µmol/L), on key functions of neutrophils isolated from healthy individuals. Cells were either pre-loaded with dehydroascorbic acid, which is rapidly reduced intracellularly to ascorbate, or the cells were activated in the presence of extracellular ascorbate. We measured the effects of enhanced ascorbate uptake on the essential functions of chemotaxis, oxidant production, programmed cell death and neutrophil extracellular trap (NET) formation. We found that neutrophils isolated from healthy individuals already had replete ascorbate status (0.35 nmol/106 cells), therefore they did not uptake additional ascorbate. However, they readily took up dehydroascorbic acid, thus significantly increasing their intracellular ascorbate concentrations, although this was found to have no additional effect on superoxide production or chemotaxis. Interestingly, extracellular ascorbate appeared to enhance directional mobilityin the presence of the chemoattractant formyl-methionyl-leucyl-phenylalanine (fMLP). Stimulation of the cells in the presence of ascorbate significantly increased intracellular ascorbate concentrations and, although this exhibited a non-significant increase in phosphatidylserine exposure, NET formation was significantly attenuated. Our findings demonstrate the ability of neutrophils to regulate their uptake of ascorbate from the plasma of healthy humans to maintain an optimal level within the cell for proper functioning. Higher oral intakes, however, may help reduce tissue damage and inflammatory pathologies associated with NET formation.
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Janjuha, Ryan, Diane Bunn, Richard Hayhoe, Lee Hooper, Asmaa Abdelhamid, Shaan Mahmood, Joseph Hayden-Case, Will Appleyard, Sophie Morris, and Ailsa Welch. "Effects of Dietary or Supplementary Micronutrients on Sex Hormones and IGF-1 in Middle and Older Age: A Systematic Review and Meta-Analysis." Nutrients 12, no. 5 (May 18, 2020): 1457. http://dx.doi.org/10.3390/nu12051457.
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Observational research suggests that micronutrients may be protective for sarcopenia, a key health issue during ageing, potentially via effects on hormone synthesis and metabolism. We aimed to carry out a systematic review of RCTs investigating effects of increasing dietary or supplemental micronutrient intake on sex hormones and IGF-1 in individuals aged 45 years or older. We searched MEDLINE, EMBASE and Cochrane databases for RCTs reporting the effects of different micronutrients (vitamins A, C, D, or E; carotenoids; iron; copper; zinc; magnesium; selenium; and potassium) on sex hormones or IGF-1. Of the 26 RCTs identified, nine examined effects of vitamin D, nine of multi-nutrients, four of carotenoids, two of selenium, one of zinc, and one of vitamin E. For IGF-1 increasing vitamin D (MD: −0.53 nmol/L, 95% CI: −1.58, 0.52), multi-nutrients (MD: 0.60 nmol/L, 95% CI −1.12 to 2.33) and carotenoids (MD −1.32 nmol/L; 95% CI −2.76 to 0.11) had no significant effect on circulating concentrations. No significant effects on sex hormones of other micronutrients were found, but data were very limited. All trials had significant methodological limitations making effects of micronutrient supplementation on sex hormones unclear. Further high quality RCTs with physiological doses of micronutrients in people with low baseline intakes or circulating concentrations, using robust methodology, are required to assess effects of supplementation adequately.
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Benzie, Iris F. F. "Vitamin C: prospective functional markers for defining optimal nutritional status." Proceedings of the Nutrition Society 58, no. 2 (May 1999): 469–76. http://dx.doi.org/10.1017/s0029665199000610.
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Most species of plants and animals synthesize ascorbic acid, but human subjects cannot, making vitamin C an essential component of our diet. Relationships between vitamin C intake and status, and between status and health are not yet clear. There is evidence, however, that higher intake of vitamin C is associated with lower risk of disease, supporting the concept that optimal intake is needed for optimal vitamin C status, and that both factors are required for optimal health. Vitamin C has low toxicity in healthy subjects, but a clear definition of optimal status and the dietary intake required to meet and maintain this status is needed before a change in the current recommended intake can be considered. Available evidence suggests that intake of 200 mg vitamin C/d saturates tissues and maintains fasting plasma levels above the proposed threshold (50 μmol/l) for minimum risk of CHD. However, the issue of whether or not these levels produce ‘optimal vitamin C status’ awaits the clear and accepted definition of the term. This definition in turn awaits the development of reliable functional markers capable of assessing the effects of varying levels of vitamin C nutriture. In the present paper the relationship between intake and body stores of vitamin C and the role of vitamin C in human health are reviewed briefly. The requirements of a reliable functional marker of human vitamin C status are defined, three classes of functional markers (molecular, biochemical and physiological) are described, and possible candidate markers are examined.
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McNulty, Patrick H., Bryan J. Robertson, Mark A. Tulli, Joshua Hess, Lisa A. Harach, Sofia Scott, and Lawrence I. Sinoway. "Effect of hyperoxia and vitamin C on coronary blood flow in patients with ischemic heart disease." Journal of Applied Physiology 102, no. 5 (May 2007): 2040–45. http://dx.doi.org/10.1152/japplphysiol.00595.2006.
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Pathological formation of reactive oxygen species within the coronary circulation has been hypothesized to mediate some clinical manifestations of ischemic heart disease (IHD) by interfering with physiological regulation of coronary tone. To determine the degree to which coronary tone responds to acute changes in ambient levels of oxidants and antioxidants in vivo in a clinical setting, we measured the effect of an acute oxidative stress (breathing 100% oxygen) on coronary capacitance artery diameter (quantitative angiography) and blood flow velocity through the coronary microcirculation (intracoronary Doppler ultrasonography) before and after treatment with the antioxidant vitamin C (3-g intravenous infusion) in 12 IHD patients undergoing a clinical coronary interventional procedure. Relative to room air breathing, 100% oxygen breathing promptly reduced coronary blood flow velocity by 20% and increased coronary resistance by 23%, without significantly changing the diameter of capacitance arteries. Vitamin C administration promptly restored coronary flow velocity and resistance to a slightly suprabasal level, and it prevented the reinduction of coronary constriction with rechallenge with 100% oxygen. This suggests that acute oxidative stress produces prompt and substantial changes in coronary resistance and blood flow in a clinical setting in patients with IHD, and it suggests that these changes are mediated by vitamin C-quenchable substances acting on the coronary microcirculation. This observation may have relevance for clinical practice.
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Bibik, Irina, Alexander Luchay, and Sergey Dotsenko. "Substantiation of technological approaches to creation of a functional product based on creamy pumpkin composition." E3S Web of Conferences 203 (2020): 04008. http://dx.doi.org/10.1051/e3sconf/202020304008.
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Scientific research and practice show that a certain part of the population of the Russian Federation has nutritional disorders. In particular, the deficiency in β-carotene is within 20%, vitamin C - 25%, iron - 35%, zinc - 35 - 45%. The analysis found that on the basis of widespread raw materials of plant origin and, in particular, carotene-containing, it is possible and advisable to create functional products containing a complex of vitamin and mineral substances with a synergistic (strengthening) effect. At the same time, the assumption was used about the possibility and feasibility of extracting β-carotene from pumpkin pulp by the fatty component of cream with a mass fraction of fat from 10% to 20%. Taking into account this approach, a basic technological scheme for obtaining food systems enriched with β-carotene has been developed. On the basis of the cream and pumpkin composition obtained according to one of the options, the recipe for the dessert chocolate paste “Armeyskaya” was developed. The possibility and expediency of creating a mayonnaise product with a relatively high protein content, a rational ratio of polyunsaturated fatty acids, as well as significant concentrations of vitamins has been substantiated. Rheological dependences and consumer properties of a mayonnaise product with a given physiological effect have been established. It was found that it contains an antioxidant complex: β-carotene + vitamin C + Zn, which has a synergistic effect. It makes it possible to recommend the product as having the effect of maintaining the activity of the cardiovascular system in accordance with the Russian national standard GOST R-54059-2010.
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Jovic, Thomas H., Stephen R. Ali, Nader Ibrahim, Zita M. Jessop, Sam P. Tarassoli, Thomas D. Dobbs, Patrick Holford, Catherine A. Thornton, and Iain S. Whitaker. "Could Vitamins Help in the Fight Against COVID-19?" Nutrients 12, no. 9 (August 23, 2020): 2550. http://dx.doi.org/10.3390/nu12092550.
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There are limited proven therapeutic options for the prevention and treatment of COVID-19. The role of vitamin and mineral supplementation or “immunonutrition” has previously been explored in a number of clinical trials in intensive care settings, and there are several hypotheses to support their routine use. The aim of this narrative review was to investigate whether vitamin supplementation is beneficial in COVID-19. A systematic search strategy with a narrative literature summary was designed, using the Medline, EMBASE, Cochrane Trials Register, WHO International Clinical Trial Registry, and Nexis media databases. The immune-mediating, antioxidant and antimicrobial roles of vitamins A to E were explored and their potential role in the fight against COVID-19 was evaluated. The major topics extracted for narrative synthesis were physiological and immunological roles of each vitamin, their role in respiratory infections, acute respiratory distress syndrome (ARDS), and COVID-19. Vitamins A to E highlighted potentially beneficial roles in the fight against COVID-19 via antioxidant effects, immunomodulation, enhancing natural barriers, and local paracrine signaling. Level 1 and 2 evidence supports the use of thiamine, vitamin C, and vitamin D in COVID-like respiratory diseases, ARDS, and sepsis. Although there are currently no published clinical trials due to the novelty of SARS-CoV-2 infection, there is pathophysiologic rationale for exploring the use of vitamins in this global pandemic, supported by early anecdotal reports from international groups. The final outcomes of ongoing trials of vitamin supplementation are awaited with interest.
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Xing, Yage, Hongbin Lin, Dong Cao, Qinglian Xu, Wenfeng Han, Ranran Wang, Zhenming Che, and Xihong Li. "Effect of Chitosan Coating with Cinnamon Oil on the Quality and Physiological Attributes of China Jujube Fruits." BioMed Research International 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/835151.
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Effects of chitosan coating with cinnamon oil on the physiological attributes and preservation quality of China jujube fruits during storage at 4°C for 60 days were investigated. Results indicated that weight loss and decay of jujube fruits were significantly reduced by chitosan-oil coating during the period of 60-day storage, which also exhibited a quite beneficial effect on maintaining the sensory quality for jujube fruits. Meanwhile, the contents of vitamin C and titratable acid decreased to 3.08 mg·g−1and 0.342% for the fruits treated by chitosan-oil coating (1.0% + 0.10%), respectively. Polyphenol oxidase, superoxide dismutase, and peroxidase activities were 13.40 U·g−1, 14.53 U·g−1, and 63.6 U·g−1at the end of storage, respectively. The contents of total soluble phenolics and MDA were 34.51 mg·g−1and 19.43μmol·g−1for the combined coating treated samples and control fruits, respectively. These results suggested that the chitosan-oil coating might be recognized as one efficiency technology on the preservation quality of jujube fruits during the storage time.
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Redmann, A., K. Möbius, HH Hiller, W. Oelkers, and V. Bähr. "Ascorbate depletion prevents aldosterone stimulation by sodium deficiency in the guinea pig." European Journal of Endocrinology 133, no. 4 (October 1995): 499–506. http://dx.doi.org/10.1530/eje.0.1330499.
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Redmann A, Möbius K, Hiller HH, Oelkers W, Bähr V. Ascorbate depletion prevents aldosterone stimulation by sodium deficiency in the guinea pig. Eur J Endocrinol 1995;133:499–506. ISSN 0804–4643 The concentration of ascorbic acid (vitamin C) in the adrenal cortex is higher than in any other organ. The role of vitamin C in the adrenal cortex is unknown, but data obtained with bovine adrenocortical cells in vitro favour its role as an antioxidant that especially protects aldosterone synthesis from damaging lipid peroxides. Alternatively, vitamin C could act as part of an auxiliary electron transport system for the last step of aldosterone synthesis. The effects of vitamin C depletion on adrenocortical function cannot be studied in the human for ethical reasons, so we subjected different groups of guinea pigs to vitamin C depletion, sodium depletion and combined vitamin C and sodium depletion. Other groups of animals on normal or vitamin C-deficient diets received high-dose adrenocorticotrophin (ACTH) injections for 3 days before sacrifice. Fifteen days of a vitamin C-free diet led to very low vitamin C levels in adrenals, liver and plasma without clear signs of scurvy. At this time, plasma aldosterone and aldosterone secretion by isolated adrenal cells were stimulated significantly by sodium deficiency. Simultaneous vitamin C depletion completely abolished the rise in aldosterone in vivo and in vitro, significantly reduced the conversion of [3H]deoxycorticosterone to [3H]aldosterone and impaired renal sodium conservation. Plasma renin activity (PRA), plasma ACTH and serum potassium were not different in the sodium-depleted and sodium plus vitamin C-depleted groups. Sodium depletion did not affect cortisol. Vitamin C depletion led to a significant increase in plasma cortisol without an increase in ACTH, while in vitro secretion of cortisol was slightly decreased. These findings seem to be due to decreased hepatic cortisol metabolism. Three days of ACTH treatment led to a large increase in plasma cortisol and in vitro cortisol secretion, while plasma aldosterone and in vitro aldosterone secretion (and PRA) were greatly suppressed. This effect of ACTH was not changed by vitamin C depletion. In conclusion, our studies have demonstrated for the first time a permissive role of vitamin C in the adaptation of aldosterone secretion and of sodium excretion to sodium deficiency, which is an important physiological function of aldosterone. The molecular mechanisms by which vitamin C is involved in aldosterone synthesis await further studies. V Bähr, Freie Universität Berlin, Klinikum Benjamin Franklin, Division of Endocrinology, Department of Medicine, Hindenburgdamm 30, D-12200 Berlin, Germany
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Basnet, Manoj, Shanta Man Shakya, and Bandhu Raj Baral. "Response of organic manures on post harvest and soil nutrient restoration on cauliflower production." Journal of Agriculture and Environment 18 (May 12, 2018): 67–72. http://dx.doi.org/10.3126/aej.v18i0.19891.
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This study was conducted at Ilam Municipality-2, Nepal to determine the response of organic manures on post harvest and nutrient restorative effect of cauliflower. Five manures, viz., bansoon, mustard oil cake, poultry manure, farmyard manure, and vermi-compost were evaluated. The postharvest losses, vitamin C content and soil nutrient restorative behavior were significantly highest with vermi-compost as compared to other manures. The maximum vitamin C content of 10.92 mg/100 gm was found with vermi-compost whereas the lowest of 9.66 mg/100 gm was found at farmyard manure. Moreover, the physiological losses were found to be least with vermi compost and the most with bansoon manure. Moreover, the restorative properties i.e. pH, N,P,K and organic %age were found to be significantly highest with vermi-compost as compared to other organic manures. This study concludes that vermi compost increases vitamin C content, postharvest longevity and improvement of physical and chemical properties of the soil.
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Lopes, Júlia Trugilio, Mayara Setúbal Oliveira-Araújo, Renata Vieira Do Nascimento, Yasmin Maia Ferreira, Assis Rubens Montenegro, and Carminda Sandra Brito Salmito-Vanderley. "Effect of Vitamins and Amino Acids as Cryoprotectant Solution Supplementation for the Cryopreservation of Tambaqui Semen (Colossoma macropomum)." Acta Scientiae Veterinariae 46, no. 1 (September 30, 2018): 8. http://dx.doi.org/10.22456/1679-9216.87223.
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Background: The addition of antioxidant substances to a cryoprotective solution can increase its protective capacity, shielding spermatozoa from the oxidative stress caused by the seminal cryopreservation process. However, there is no record of a seminal cryopreservation protocol of tambaqui (Colossoma macropomum) using antioxidants as a supplement to the cryoprotective solution. Thus, the objective of this study was to evaluate the effects of adding vitamin C, vitamin E, cysteine, and/or taurine to the seminal cryopreservation of tambaqui.Materials, Methods & Results: Pools of semen (n = 10) were diluted in cryoprotective solutions supplemented with: vitamin C (T1), vitamin E (T2), vitamin C + vitamin E (T3), cysteine (T4), taurine (T5), and taurine + cysteine (T6). The control treatment (T7) was not supplemented. Diluted semen was loaded in 0.5 mL straws, frozen in a dry-shipper, stored in a cryogenic cylinder, and then thawed in a water bath (45ºC for eight seconds). The quality of fresh and cryopreserved semen was evaluated by measuring total motility, progressive motility, curvilinear velocity (VCL), straight line velocity (VSL), average path velocity (VAP), linearity, and straightness using a computerized system of sperm analysis. Sperm membrane integrity parameters were analyzed using eosin-nigrosin staining, sperm morphology was assessed using pink bengal staining, and motility duration was measured by a digital timer. Data were analyzed using the statistical program SAS (2002) and the results were expressed as means ± standard error of the mean. The results showed that, in general, there was no significant increase in seminal quality when antioxidants were added to the cryoprotective solution. The T5 treatment promoted an increase (P < 0.05) in progressive motility when compared to T1 (6.33 ± 1.14% and 2.98 ± 0.88%, respectively). However, it did not differ significantly (P > 0.05) from the other treatments. Treatments T2 and T5 presented the highest values of VCL (34.74 ± 2.58 and 33.60 ± 1.81 μm.s-1, respectively). These were higher (P < 0.05) than T1 (26.31 ± 1.64 μm.s-1) but not different (P > 0.05) from the T7 control (30.87 ± 1.49 μm.s-1). The VSL and VAP results showed that T1 presented the lowest velocity (9.89 ± 1.75 and 15.06 ± 1.92 μm.s-1, respectively) compared to the other treatments (P < 0.05) that did not differ from each other. Combining the two vitamins (T3) or the two amino acids (T6) was not advantageous in relation to the use of only one of these antioxidants.Discussion: The present study reports, for the first time, results of the addition of antioxidants to the tambaqui seminal freezing medium. The addition of taurine and vitamin E, although not significantly different from the control treatment, resulted in a tendency to increase sperm kinetics. This effect may be due to the action of taurine as a regulator of Ca2+ transporters, which is necessary to trigger sperm activation, and to the ability of vitamin E to scavenge reactive oxygen species produced during lipid peroxidation. On the other hand, the reduced sperm quality observed when vitamin C was used may have been related to the toxicity caused by a high concentration of this vitamin. In addition, once the safe dose of antioxidants has been exceeded, the normal physiological functions of reactive oxygen species can be inhibited. Thus, it is concluded that the use of vitamin E and taurine promotes promising results of curvilinear velocity after thawing of sperm. Therefore, these treatments are recommended, as well as more tests to determine their optimal concentrations.
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Daader, Ahmed H., Adham A. Al-Sagheer, Hassan A. Gabr, and Elham A. Abd El-Moniem. "Alleviation of heat-stress-related physiological perturbations in growing rabbits using natural antioxidants." Spanish Journal of Agricultural Research 16, no. 3 (October 23, 2018): e0610. http://dx.doi.org/10.5424/sjar/2018163-13184.
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The current study was performed to evaluate the effects of the dietary inclusion of extra virgin olive oil (EVOO), betaine (BET), lemongrass essential oil (LGEO), gallic acid (GA), vitamin C (VC) and vitamin E (VE) on different body temperature traits and stress hormone and glucose levels in heat-stressed growing rabbits. Rabbits were fed diets with no supplementation (control group) or supplemented with 15 g of EVOO, 400 mg of LGEO, 500 mg of GA, 1000 mg of BET, 500 mg of VC, or 200 mg of VE per kg of diet. All tested feed additives, especially EVOO, had a lowering effect on various rabbit temperature traits. Both triiodothyronine (T3) and tetraiodothyronine/thyroxine (T4) were increased (p<0.05) by the addition of BET, VC, EVOO, and VE. With the exception of the VC group, all dietary groups showed no significant changes in the insulin level compared to the control group level. In contrast, the cortisol and glucose levels were diminished (p<0.05) in all treated groups compared to the control levels. The results suggested that all tested supplementations had positive ameliorating effects on growing rabbits under a severe heat load in terms of lowered body temperatures and a favourable stress hormone balance, with the most favourable results found in the EVOO, VC, and BET supplementation groups.
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Hashem, N. M., D. Abd-Elrazek, Z. R. Abo-Elezz, and M. G. A. Latif. "Effect of vitamin A or C on physiological and reproductive response of Rahmani ewes during subtropical summer breeding season." Small Ruminant Research 144 (November 2016): 313–19. http://dx.doi.org/10.1016/j.smallrumres.2016.10.013.
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Chemerys, I., O. Myslyuk, and V. Chemerys. "Effect of vehicle emissions on the morphological and physiological changes of Taraxacum officinale web." Ukrainian Journal of Ecology 10, no. 1 (February 1, 2020): 7–17. http://dx.doi.org/10.15421/2020_2.
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Road transport is one of the main pollutants of atmospheric air and soil in modern cities, therefore, an important issue is the comprehensive diagnosis of the state of the environment, which can be carried out by phytoindication methods, and which make it possible to comprehensively assess the environmental risks of the roadside environment for living organisms. The article analyzes the morphological and physiological changes of Taraxacum officinale Web. that occurred under the influence of vehicle emissions. For research, we chose a territory with significant aerotechnogenic loads due to both stationary sources of pollution and traffic flows –the southwestern district of the city for the analysis of plants, the following indicators were studied: mass of plants; leaf length;proportion of altered forms; ascorbic acid content; chlorophyll concentration. In the study, biometric, spectrophotometric and statistical methods were used. The results of the studies showed that in all plants inhibition of parameters was observed in comparison with the control samples. An analysis of the tightness of the relationship between the morphophysiological parameters of the plant, the traffic intensity and the distance from the road were influenced by the average mass of plants (r=0.97) in the area with heavy traffic, the content of chlorophyll (r=0.92) in the same area, the proportion of altered forms (r=-0.94). The correlation coefficient of the proportion of altered forms is negative, since the number of altered forms decreases with increasing distance from the road. It was found, that content of chlorophyll depends on traffic intensity and the distance from the road (the correlation coefficient ranged from 0.88–0.97). Indicators of leaf length and vitamin C content turned out to be less informative, since there is no clear relationship between these indicators and distance from the road (r=0.54), although with an increase in the distance from the highway, there is a slight increase in leaf length, but the content of vitamin C did not show depending on the distance to the road. The further developments lies in the refinement of the information content of such an indicator as the content of ascorbic acid in order to use it to indicate invisible changes in the vegetation cover.
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Macias, Rocio I. R., Carlos Hierro, Susana Cuesta de Juan, Felipe Jimenez, Francisco Gonzalez-San Martin, and Jose J. G. Marin. "Hepatic expression of sodium-dependent vitamin C transporters: ontogeny, subtissular distribution and effect of chronic liver diseases." British Journal of Nutrition 106, no. 12 (July 1, 2011): 1814–25. http://dx.doi.org/10.1017/s0007114511002273.
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Ascorbic acid uptake is a key step in determining the overall bioactivity of this vitamin. Expression of Na-dependent vitamin C transporters (SVCT; SLC23A1 and SLC23A2) during long-term oxidative stress occurring in several chronic liver diseases may determine the antioxidant defence in this organ. In patients with hepatocellular cholestasis, primary biliary cirrhosis, haemochromatosis and non-alcoholic steatohepatitis, using real-time RT-PCR, an enhanced hepatic expression of both SLC23A1 and SLC23A2, but not other organic anions transporters, such as OATP1A2, OATP1B1 and OATP1B3, was found. To further investigate these findings, we used secondary biliary cirrhosis induced in rats by long-term biliary obstruction as a model of chronic liver disease accompanied by oxidative stress because of bile acid accumulation. In control rat liver, expression of Slc23a1 was low at birth, increased progressively up to adulthood and decreased in senescence, whereas expression of Slc23a2 did not change significantly after birth. In 8-week-old rats, immunohistochemistry and confocal microscopy studies revealed the expression in hepatocytes and bile duct cells of mainly Slc23a1, whereas both Slc23a1 and Slc23a2 were expressed in endothelial, stellate and Kupffer cells. In adult rats, when obstructive cholestasis was maintained for 8 weeks, a significant up-regulation of Slc23a2 accompanied by a down-regulation of Slc23a1 was found. In sum, there is a selective cell-type distribution of SVCT in the liver tissue, which, in addition to differential control in the expression of both isoforms, may play a role in the ability of different liver cell types to take up vitamin C under physiological and pathological conditions.
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Green, J., K. V. Luong, C. R. Kleeman, L. H. Ye, and C. Chaimovitz. "1,25-Dihydroxyvitamin D3 inhibits Na(+)-dependent phosphate transport in osteoblastic cells." American Journal of Physiology-Cell Physiology 264, no. 2 (February 1, 1993): C287—C295. http://dx.doi.org/10.1152/ajpcell.1993.264.2.c287.
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In the present work we investigated the influence of vitamin D3 metabolites on Na(+)-dependent phosphate (Pi) transport in the clonal osteoblastic cell line UMR-106. The vitamin D3 metabolite 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] dose-dependently inhibited Pi transport with a half-maximal concentration of approximately 5 x 10(-11) M. The effect of 1,25(OH)2D3 was first observed after 8 h of preincubation period. Inhibition of phosphate uptake was relatively specific for the 1,25(OH)2D3 analogue of vitamin D3. The potency order was 1,25(OH)2D3 >> 24,25-dihydroxyvitamin D3 > 25-[3H]hydroxyvitamin D3. Kinetically, 1,25(OH)2D3 decreased the maximal velocity of the phosphate uptake system, whereas the affinity for phosphate was unaffected. Activation of protein kinase C (PKC) in UMR-106 cells stimulated Na(+)-dependent Pi transport. Nonetheless, the inhibitory effect of 1,25(OH)2D3 on Pi transport was not related to downregulation of PKC. Chemical determination of intracellular Pi showed a 50% reduction after 24-h preincubation with 10(-8) M 1,25(OH)2D3. We conclude that 1,25(OH)2D3 inhibits Na(+)-dependent phosphate transport in osteoblastic cells. This in turn leads to intracellular Pi depletion. The physiological implication of this phenomenon on the effects of vitamin D on osteoblasts in situ is discussed.