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1

Goodman, William G. "Vitamin D metabolism." Current Opinion in Orthopaedics 5, no. 5 (October 1994): 60–65. http://dx.doi.org/10.1097/00001433-199410000-00010.

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2

Swaminathan, R. "Vitamin D Metabolism." Annals of Clinical Biochemistry: An international journal of biochemistry and laboratory medicine 32, no. 1 (January 1, 1995): 98–100. http://dx.doi.org/10.1177/000456329503200114.

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3

Christakos, Sylvia, Dare V. Ajibade, Puneet Dhawan, Adam J. Fechner, and Leila J. Mady. "Vitamin D: Metabolism." Rheumatic Disease Clinics of North America 38, no. 1 (February 2012): 1–11. http://dx.doi.org/10.1016/j.rdc.2012.03.003.

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4

Christakos, Sylvia, Dare V. Ajibade, Puneet Dhawan, Adam J. Fechner, and Leila J. Mady. "Vitamin D: Metabolism." Endocrinology and Metabolism Clinics of North America 39, no. 2 (June 2010): 243–53. http://dx.doi.org/10.1016/j.ecl.2010.02.002.

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5

Lehmann, Bodo, and Michael Meurer. "Vitamin D metabolism." Dermatologic Therapy 23, no. 1 (January 2010): 2–12. http://dx.doi.org/10.1111/j.1529-8019.2009.01286.x.

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6

Salle, B. L., F. H. Glorieux, and N. Bishop. "Perinatal vitamin D metabolism." Seminars in Neonatology 3, no. 2 (May 1998): 143–47. http://dx.doi.org/10.1016/s1084-2756(98)80032-8.

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7

Salle, B. L., F. H. Glorieux, and E. E. Delvin. "Perinatal Vitamin D Metabolism." Neonatology 54, no. 4 (1988): 181–87. http://dx.doi.org/10.1159/000242850.

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8

Ramasamy, Indra. "Vitamin D Metabolism and Guidelines for Vitamin D Supplementation." Clinical Biochemist Reviews 41, no. 3 (December 8, 2020): 103–26. http://dx.doi.org/10.33176/aacb-20-00006.

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Vitamin D is essential for bone health and is known to be involved in immunomodulation and cell proliferation. Vitamin D status remains a significant health issue worldwide. However, there has been no clear consensus on vitamin D deficiency and its measurement in serum, and clinical practice of vitamin D deficiency treatment remains inconsistent. The major circulating metabolite of vitamin D, 25-hydroxyvitamin D (25(OH)D), is widely used as a biomarker of vitamin D status. Other metabolic pathways are recognised as important to vitamin D function and measurement of other metabolites may become
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9

Thomas, Melissa K., and Marie B. Demay. "VITAMIN D DEFICIENCY AND DISORDERS OF VITAMIN D METABOLISM." Endocrinology and Metabolism Clinics of North America 29, no. 3 (September 2000): 611–27. http://dx.doi.org/10.1016/s0889-8529(05)70153-5.

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10

Jovičić, Snežana, Svetlana Ignjatović, and Nada Majkić-Singh. "Biochemistry and metabolism of vitamin D / Biohemija i metabolizam vitamina D." Journal of Medical Biochemistry 31, no. 4 (October 1, 2012): 309–15. http://dx.doi.org/10.2478/v10011-012-0028-8.

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Summary Vitamin D is not technically a vitamin, since it is not an essential dietary factor. It is rather a prohormone produced photochemically in the skin from 7-dehydrocholesterol. Vitamin D and its metabolites may be categorized as either cholecalciferols or ergocalciferols. Cholecalciferol (vi - tamin D3) is the parent compound of the naturally occurring family and is produced in the skin from 7-dehydrocholesterol on exposure to the ultraviolet B portion of sunlight. Vitamin D2 (ergocalciferol), the parent compound of the other family, is manufactured by irradiation of ergosterol produced
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11

Lawson-Matthew, Peter, Jill Clayton, Diane Guilland-Cumming, Ashley Yates, Eric Preston, Michael Greaves, and John A. Kanis. "Vitamin D metabolism in myeloma." British Journal of Haematology 73, no. 1 (September 1989): 57–60. http://dx.doi.org/10.1111/j.1365-2141.1989.tb00220.x.

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12

Salle, Bernard L., Edgar E. Delvin, Alexandre Lapillonne, Nicholas J. Bishop, and Francis H. Glorieux. "Perinatal metabolism of vitamin D." American Journal of Clinical Nutrition 71, no. 5 (May 1, 2000): 1317S—1324S. http://dx.doi.org/10.1093/ajcn/71.5.1317s.

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13

Mawer, E. B., and M. Davies. "Vitamin D metabolism in lymphoma." Bone 7, no. 4 (1986): 304. http://dx.doi.org/10.1016/8756-3282(86)90215-2.

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14

Henry, Helen L. "Regulation of vitamin D metabolism." Best Practice & Research Clinical Endocrinology & Metabolism 25, no. 4 (August 2011): 531–41. http://dx.doi.org/10.1016/j.beem.2011.05.003.

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15

Bouillon, R., G. Carmeliet, E. Daci, S. Segaert, and A. Verstuyf. "Vitamin D Metabolism and Action." Osteoporosis International 8, S2 (September 1998): S13—S19. http://dx.doi.org/10.1007/pl00022727.

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16

Smith, R. "Vitamin D metabolism—An update." Current Orthopaedics 2, no. 2 (April 1988): 90–93. http://dx.doi.org/10.1016/0268-0890(88)90007-2.

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17

Dawson-Hughes, B. "Calcium, vitamin D and vitamin D metabolites." Osteoporosis International 6, S1 (January 1996): 93. http://dx.doi.org/10.1007/bf02499912.

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18

Miller, Walter L., and Erik A. Imel. "Rickets, Vitamin D, and Ca/P Metabolism." Hormone Research in Paediatrics 95, no. 6 (2022): 579–92. http://dx.doi.org/10.1159/000527011.

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Rickets was a major public health problem dating from Roman times, and medical descriptions of rickets date from the 17th century. Sniadecki first advocated treatment by exposure to sunshine in 1822; contemporaneously, several British physicians advocated use of cod liver oil. Both approaches were successful. Work in 1924 showed that exposure to UV light endowed fats and other foods with antirachitic properties. Vitamins D<sub>2</sub> and D<sub>3</sub>, the antirachitic agent in cod liver oil, were, respectively, produced by UV radiation of ergosterol and 7-dehydrochole
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19

Kaminsky, O. V. "Vitamin D dosage." INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) 17, no. 5 (January 4, 2022): 435–42. http://dx.doi.org/10.22141/2224-0721.17.5.2021.241524.

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Despite its historical name, vitamin D is not a vitamin at all but a hormone that, when activated, is a metabolically active steroid fat-soluble hormone that acts on cellular receptors. Vitamin D hormone is synthesized endogenously and then metabolized in the body, provi-ding that there are the necessary precursors and some factors — the effects of ultraviolet light on the skin. At the same time, vitamins themselves are nutrients, co-factors of biochemical reactions that are not synthesized in the body and cannot interact with receptors, consumed with food, so the hormone D is not a vitamin. D
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20

Karamali, Maryam, Mahnaz Ashrafi, Maryamalsadat Razavi, Mehri Jamilian, Maryam Akbari, and Zatollah Asemi. "The Effects of Calcium, Vitamins D and K co-Supplementation on Markers of Insulin Metabolism and Lipid Profiles in Vitamin D-Deficient Women with Polycystic Ovary Syndrome." Experimental and Clinical Endocrinology & Diabetes 125, no. 05 (April 13, 2017): 316–21. http://dx.doi.org/10.1055/s-0043-104530.

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Abstract Data on the effects of calcium, vitamins D and K co-supplementation on markers of insulin metabolism and lipid profiles among vitamin D-deficient women with polycystic ovary syndrome (PCOS) are scarce. This study was done to determine the effects of calcium, vitamins D and K co-supplementation on markers of insulin metabolism and lipid profiles in vitamin D-deficient women with PCOS. This randomized double-blind, placebo-controlled trial was conducted among 55 vitamin D-deficient women diagnosed with PCOS aged 18–40 years old. Subjects were randomly assigned into 2 groups to intake ei
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21

Dusso, Adriana S., Alex J. Brown, and Eduardo Slatopolsky. "Vitamin D." American Journal of Physiology-Renal Physiology 289, no. 1 (July 2005): F8—F28. http://dx.doi.org/10.1152/ajprenal.00336.2004.

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The vitamin D endocrine system plays an essential role in calcium homeostasis and bone metabolism, but research during the past two decades has revealed a diverse range of biological actions that include induction of cell differentiation, inhibition of cell growth, immunomodulation, and control of other hormonal systems. Vitamin D itself is a prohormone that is metabolically converted to the active metabolite, 1,25-dihydroxyvitamin D [1,25(OH)2D]. This vitamin D hormone activates its cellular receptor (vitamin D receptor or VDR), which alters the transcription rates of target genes responsible
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22

Saponaro, Federica, Alessandro Saba, and Riccardo Zucchi. "An Update on Vitamin D Metabolism." International Journal of Molecular Sciences 21, no. 18 (September 8, 2020): 6573. http://dx.doi.org/10.3390/ijms21186573.

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Vitamin D is a steroid hormone classically involved in the calcium metabolism and bone homeostasis. Recently, new and interesting aspects of vitamin D metabolism has been elucidated, namely the special role of the skin, the metabolic control of liver hydroxylase CYP2R1, the specificity of 1α-hydroxylase in different tissues and cell types and the genomic, non-genomic and epigenomic effects of vitamin D receptor, which will be addressed in the present review. Moreover, in the last decades, several extraskeletal effects which can be attributed to vitamin D have been shown. These beneficial effec
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23

Patil, Dr Vishakha S. "Vitamin D: A Review on Metabolism and Regulating Factors (Part I)." Journal of Medical Science And clinical Research 04, no. 12 (December 24, 2016): 14871–77. http://dx.doi.org/10.18535/jmscr/v4i12.92.

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24

Moriya, Aya, Tsutomu Fukuwatari, Mitsue Sano, and Katsumi Shibata. "Different variations of tissue B-group vitamin concentrations in short- and long-term starved rats." British Journal of Nutrition 107, no. 1 (June 27, 2011): 52–60. http://dx.doi.org/10.1017/s0007114511002339.

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Prolonged starvation changes energy metabolism; therefore, the metabolic response to starvation is divided into three phases according to changes in glucose, lipid and protein utilisation. B-group vitamins are involved in energy metabolism via metabolism of carbohydrates, fatty acids and amino acids. To determine how changes in energy metabolism alter B-group vitamin concentrations during starvation, we measured the concentration of eight kinds of B-group vitamins daily in rat blood, urine and in nine tissues including cerebrum, heart, lung, stomach, kidney, liver, spleen, testis and skeletal
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25

Alshahrani, Fahad M., Mussa H. Almalki, Naji Aljohani, Abdullah Alzahrani, Yousef Alsaleh, and Michael F. Holick. "Vitamin D." Dermato-Endocrinology 5, no. 1 (January 2013): 177–80. http://dx.doi.org/10.4161/derm.23351.

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26

Gröber, Uwe, Jörg Spitz, Jörg Reichrath, Klaus Kisters, and Michael F. Holick. "Vitamin D." Dermato-Endocrinology 5, no. 3 (June 2013): 331–47. http://dx.doi.org/10.4161/derm.26738.

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27

Detopoulou, Paraskevi, Sousana K. Papadopoulou, Gavriela Voulgaridou, Vasileios Dedes, Despoina Tsoumana, Aristea Gioxari, George Gerostergios, Maria Detopoulou, and George I. Panoutsopoulos. "Ketogenic Diet and Vitamin D Metabolism: A Review of Evidence." Metabolites 12, no. 12 (December 19, 2022): 1288. http://dx.doi.org/10.3390/metabo12121288.

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The ketogenic diet (KD), which is low in carbohydrates and high to normal in fat and protein, has been traditionally used in epilepsy for the last 100 years. More recently, its application in obesity has been introduced. The present review aimed to investigate the effects of the KD on vitamin D. In total, five studies were done in healthy adults, one in subjects with type 2 diabetes, and seven in subjects with epilepsy that assessed the levels of vitamin D pre- and post-intervention. In the majority of studies, increases in circulating vitamin D were reported. The relationship of the KD with v
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28

Maylyan, E. A., N. A. Rheznichenko, and D. E. Maylyan. "VITAMIN D REGULATION OF BONE METABOLISM." Medical Herald of the South of Russia, no. 1 (January 1, 2017): 12–20. http://dx.doi.org/10.21886/2219-8075-2017-1-12-20.

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29

Kimura, Saburo, Yoshiki Seino, Tokuzo Harada, Osamu Nose, Kanji Yamaoka, Kazuo Shimizu, Hiroyuki Tanaka, et al. "Vitamin D Metabolism in Biliary Atresia." Journal of Pediatric Gastroenterology and Nutrition 7, no. 3 (May 1988): 341–46. http://dx.doi.org/10.1097/00005176-198805000-00005.

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30

KOBAYASHI, TADASHI. "Metabolism of vitamin D and calcium." Eisei kagaku 33, no. 5 (1987): 300–312. http://dx.doi.org/10.1248/jhs1956.33.300.

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31

Khokhar, Aditi, Salvador Castells, and Sheila Perez-Colon. "Genetic Disorders of Vitamin D Metabolism." Clinical Pediatrics 55, no. 5 (December 23, 2015): 404–14. http://dx.doi.org/10.1177/0009922815623231.

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32

Fraser, David R. "Vitamin D Deficiency and Energy Metabolism." Endocrinology 156, no. 6 (June 1, 2015): 1933–35. http://dx.doi.org/10.1210/en.2015-1298.

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33

Lagishetty, Venu, Nancy Q. Liu, and Martin Hewison. "Vitamin D metabolism and innate immunity." Molecular and Cellular Endocrinology 347, no. 1-2 (December 2011): 97–105. http://dx.doi.org/10.1016/j.mce.2011.04.015.

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34

Morris, Howard A., and Paul H. Anderson. "Vitamin D metabolism and biological activities." Molecular and Cellular Endocrinology 347, no. 1-2 (December 2011): 1–2. http://dx.doi.org/10.1016/j.mce.2011.06.018.

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35

Bosworth, Cortney, and Ian H. de Boer. "Impaired Vitamin D Metabolism in CKD." Seminars in Nephrology 33, no. 2 (March 2013): 158–68. http://dx.doi.org/10.1016/j.semnephrol.2012.12.016.

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36

Steinherz, R., A. Metzker, B. Eisenstein, and R. Samuel. "Vitamin D metabolism in tumoral calcinosis." European Journal of Pediatrics 148, no. 5 (February 1989): 475. http://dx.doi.org/10.1007/bf00595920.

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37

Chakhtoura, Marlene, Maya Rahme, and Ghada El-Hajj Fuleihan. "Vitamin D Metabolism in Bariatric Surgery." Endocrinology and Metabolism Clinics of North America 46, no. 4 (December 2017): 947–82. http://dx.doi.org/10.1016/j.ecl.2017.07.006.

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38

Carpenter, Thomas O. "Mineral regulation of vitamin D metabolism." Bone and Mineral 5, no. 3 (March 1989): 259–69. http://dx.doi.org/10.1016/0169-6009(89)90004-4.

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39

Berry, Jacqueline L., Michael Davies, and Andrew P. Mee. "Vitamin D Metabolism, Rickets, and Osteomalacia." Seminars in Musculoskeletal Radiology 06, no. 3 (2002): 173–82. http://dx.doi.org/10.1055/s-2002-36714.

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40

Kobayashi, Tadashi. "Metabolism of Vitamin D and Calcium." Japanese Journal of Nutrition and Dietetics 55, no. 5 (1997): 217–29. http://dx.doi.org/10.5264/eiyogakuzashi.55.217.

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41

Salle, B. L., J. Senterre, F. H. Glorieux, E. E. Delvin, and G. Putet. "Vitamin D Metabolism in Preterm Infants." Neonatology 52, no. 1 (1987): 119–30. http://dx.doi.org/10.1159/000242749.

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42

Landrier, Jean‐François, Lourdes Mounien, and Franck Tourniaire. "Obesity and Vitamin D Metabolism Modifications." Journal of Bone and Mineral Research 34, no. 7 (May 29, 2019): 1383. http://dx.doi.org/10.1002/jbmr.3739.

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43

Griffiths, Paul, and Angela Fairney. "Vitamin D metabolism in polar vertebrates." Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 91, no. 3 (January 1988): 511–16. http://dx.doi.org/10.1016/0305-0491(88)90014-4.

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44

Kochneva, E. V., S. Yu Kalinchenko, and D. V. Makharoblishvili. "Vitamin D deficiency: a pandemic of the 21st century. Problems of standardization of diagnosis of vitamin D deficiency." Voprosy dietologii 11, no. 1 (2021): 33–43. http://dx.doi.org/10.20953/2224-5448-2021-1-33-43.

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Vitamin D deficiency is a noninfectious pandemic of the 21st century. Vitamin D, apart from its role in phosphorus-calcium metabolism, is vital for functioning of all organs and systems, and its deficiency is a risk factor of developing aging-associated extraskeletal diseases. Vitamin D deficiency is a multifactor process related to a decreased synthesis of endogenous cholecalcipherol, insufficient intake of exogenous vitamin D and its disordered metabolism. Improvement of the effectiveness of therapeutic and preventive measures for management of vitamin D deficiency is impossible without accu
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45

Marushko, Yu V., and T. V. Hyshchak. "Prevention of vitamin D deficiency in children. The state of the problem in the world and in Ukraine." Modern pediatrics. Ukraine, no. 4(116) (May 26, 2021): 36–45. http://dx.doi.org/10.15574/sp.2021.116.36.

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The article presents current data on the prevalence of vitamin D deficiency and criteria for its deficiency in children in different countries. Vitamin D is recognized as one of the most important vitamins involved in many biochemical processes in the body. Its active metabolites play a key role in calcium absorption, bone mineralization and promote phosphate and magnesium metabolism. At the same time, in addition to affecting mineral metabolism, there is a wide range of conditions in which vitamin D also plays a preventive role. Vitamin D has been shown to play a vital role in innate immunity
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46

Hurst, Emma A., Natalie Z. Homer, and Richard J. Mellanby. "Vitamin D Metabolism and Profiling in Veterinary Species." Metabolites 10, no. 9 (September 15, 2020): 371. http://dx.doi.org/10.3390/metabo10090371.

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The demand for vitamin D analysis in veterinary species is increasing with the growing knowledge of the extra-skeletal role vitamin D plays in health and disease. The circulating 25-hydroxyvitamin-D (25(OH)D) metabolite is used to assess vitamin D status, and the benefits of analysing other metabolites in the complex vitamin D pathway are being discovered in humans. Profiling of the vitamin D pathway by liquid chromatography tandem mass spectrometry (LC-MS/MS) facilitates simultaneous analysis of multiple metabolites in a single sample and over wide dynamic ranges, and this method is now consi
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47

MAWER, E. BARBARA, S. W. STANBURY, M. J. ROBINSON, J. JAMES, and C. CLOSE. "VITAMIN D NUTRITION AND VITAMIN D METABOLISM IN THE PREMATURE HUMAN NEONATE." Clinical Endocrinology 25, no. 6 (December 1986): 641–49. http://dx.doi.org/10.1111/j.1365-2265.1986.tb03619.x.

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48

Nicolaidou, Polyxeni, Anna Papadopoulou, Helen Georgouli, Y. G. Matsinos, Helen Tsapra, Andreas Fretzayas, Aglaia Giannoulia-Karantana, et al. "Calcium and Vitamin D Metabolism in Hypocalcemic Vitamin D-Resistant Rickets Carriers." Hormone Research in Paediatrics 65, no. 2 (2006): 83–88. http://dx.doi.org/10.1159/000091043.

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49

van Ballegooijen, Adriana J., Stefan Pilz, Andreas Tomaschitz, Martin R. Grübler, and Nicolas Verheyen. "The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review." International Journal of Endocrinology 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/7454376.

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Vitamins D and K are both fat-soluble vitamins and play a central role in calcium metabolism. Vitamin D promotes the production of vitamin K-dependent proteins, which require vitamin K for carboxylation in order to function properly. The purpose of this review is to summarize available evidence of the synergistic interplay between vitamins D and K on bone and cardiovascular health. Animal and human studies suggest that optimal concentrations of both vitamin D and vitamin K are beneficial for bone and cardiovascular health as supported by genetic, molecular, cellular, and human studies. Most cl
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50

Maltsev, S. V. "Current perspectives of using vitamin D in clinical practice." Russian Journal of Woman and Child Health 5, no. 3 (2022): 244–52. http://dx.doi.org/10.32364/2618-8430-2022-5-3-244-252.

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An approach to problem solving in public health has revived interest to the prevalence rate of vitamin D deficiency, its role in the pathogenesis of various disease, and strategies for treating vitamin D deficiency. The article presents updates on vitamin D metabolism — its classical and non-calcemic actions. The emphasis is made on the effects of its individual metabolites and other components of the vitamin D endocrine system, such as hydrolase, vitamin-D receptors, and vitamin-D-binding protein (VDBP). The functions of vitamin D are characterized as genomic and non-genomic, including immuno
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