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1

Trinh Minh, Trang, Doanh Le Huu, Thuong Nguyen Van, et al. "Successful Treatment of Vitiligo Vietnamese Patients with Vitilinex® Herbal Bio-Actives in Combination with Phototherapy." Open Access Macedonian Journal of Medical Sciences 7, no. 2 (2019): 283–86. http://dx.doi.org/10.3889/oamjms.2019.095.

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BACKGROUND: Vitiligo is an acquired pigmentary disease, that causes progressive loss of melanocytes, resulting in hypopigmented skin patches. Current treatments aim at stopping the disease progression and achieving repigmentation of the amelanotic areas. Corticosteroids, surgery, topical immunomodulators, total depigmentation of normal pigmented skin and phototherapy are current treatment options for vitiligo although phototherapy remains the treatment of choice. There is no documented evidence that herbal bio-active products may also be effective treatment options for vitiligo.
 AIM: Thi
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Journal, Baghdad Science. "We study the effect of Ultra violet rays (A-B) in treatment of Vitiligo (applied Therapy)." Baghdad Science Journal 11, no. 1 (2014): 85–92. http://dx.doi.org/10.21123/bsj.11.1.85-92.

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This research evaluated the effect of (UV)(400-320A)Hz(320-220B)Hz on the patient with vitiligo , using it with our new combing therapy that include the oral (Psorlene ) topical , meladinine solution applied on the Vitiligiousns Lesions , In edition to the instralesnional injection in the Vitiligiousns Lesions by long acting steroid (kenacort-A ) by aprecentage of (5%) , after that we expose the patient to UV . The ruslets of this way of treatment more effective by using of the UV rays in the treatment of vitiligo , while the previous treatment that used the UV ray with or with out the psorlen
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Várvölgyi, Tünde, and Andrea Szegedi. "Vitiligo." Bőrgyógyászati és Venerológiai Szemle 97, no. 3 (2021): 158–66. http://dx.doi.org/10.7188/bvsz.2021.97.3.5.

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The prevalence of vitiligo is between 0.5% and 1% in the population, the most common acquired depigmentation disorder. Hypopigmented macules are formed as a result of melanocyte death. Its etiology is still not fully elucidated, it is a multifactorial disease. Polygenic type genetic susceptibility is supported by familial accumulation (15- 30%). The complex interaction of non-immunological and immunological factors is key during the development of the disease. Due to intensive research in recent years, it has become clear that cells other than melanocytes, such as keratinocytes, fibroblasts, n
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Prcic, Sonja, Verica Djuran, and Mirjana Poljacki. "Childhood vitiligo." Medical review 55, no. 11-12 (2002): 475–80. http://dx.doi.org/10.2298/mpns0212475p.

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Introduction Vitiligo is an acquired, sometimes familial skin depigmentation disorder due to selective destruction of melanocytes. Vitiligo is primarily a disease of the young; in about half of patients it occurs before the age of twenty. The aim of this study was to investigate some epidemiological and clinical characteristics of vitiligo in children, in relation to adults with vitiligo and children without vitiligo. Material and methods The research was conducted in fifty children with clinically diagnosed vitiligo (2 to 16 years of age). Children were compared with control groups of childre
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Prcic, Sonja, Verica Djuran, Mirjana Poljacki, Lada Petrovic, Anica Jakovljevic, and Mira Jokic. "Autoantibodies in children with vitiligo." Medical review 57, no. 7-8 (2004): 386–90. http://dx.doi.org/10.2298/mpns0408386p.

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Introduction Vitiligo is an acquired, sometimes familial skin depigmentation disorder. In about half of patients it occurs before the age of twenty. The aim of this study was to investigate the incidence and significance of autoantibodies (AT) and associated autoimmune and endocrine diseases in children with vitiligo, in relation to adults with vitiligo and children without vitiligo. Material and methods The research was conducted in fifty children with clinically diagnosed vitiligo from 2 to 16 years of age. Children were compared with control groups of children with other skin diseases (aged
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Oh, Sang Ho. "Classification and diagnosis of vitiligo." Journal of the Korean Medical Association 63, no. 12 (2020): 731–40. http://dx.doi.org/10.5124/jkma.2020.63.12.731.

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Vitiligo is a relatively common, acquired hypopigmentary disorder caused by the loss of epidermal melanocytes. It is characterized by asymptomatic, well-circumscribed round to oval-shaped whitish patches that vary in size. Depending on various clinical features, vitiligo is classified into several types, that is, non-segmental, segmental, and undetermined/unclassified vitiligo. The uniform classification of vitiligo is very important in predicting its clinical course and prognosis and communication among researchers. In particular, segmental vitiligo is a highly distinctive subtype of vitiligo
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7

Casey, Chelsea, and Stephen E. Weis. "Insight into Natural History of Congenital Vitiligo: A Case Report of a 23-Year-Old with Stable Congenital Vitiligo." Case Reports in Dermatological Medicine 2017 (2017): 1–3. http://dx.doi.org/10.1155/2017/5172140.

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Vitiligo is a disorder of skin pigmentation. It affects approximately 1% of the world’s population. Vitiligo occurs equally between the sexes with no racial predilections. The majority of cases are acquired and arise between the second and third decades of life. Acquired vitiligo has an unpredictable clinical course. Congenital vitiligo is rare with few reported cases. Due to the rarity of congenital vitiligo, little is known about the clinical course. For patients with acquired or congenital vitiligo, the psychosocial burden can have a profound impact on quality of life. The unknown course of
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8

Bergqvist, Christina, and Khaled Ezzedine. "Vitiligo: A Review." Dermatology 236, no. 6 (2020): 571–92. http://dx.doi.org/10.1159/000506103.

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Vitiligo, a common depigmenting skin disorder, has an estimated prevalence of 0.5–2% of the population worldwide. The disease is characterized by the selective loss of melanocytes which results in typical nonscaly, chalky-white macules. In recent years, considerable progress has been made in our understanding of the pathogenesis of vitiligo which is now clearly classified as an autoimmune disease. Vitiligo is often dismissed as a cosmetic problem, although its effects can be psychologically devastating, often with a considerable burden on daily life. In 2011, an international consensus classif
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9

Bae, Jung Min, Kee Yang Chung, Sook Jung Yun, et al. "Markedly Reduced Risk of Internal Malignancies in Patients With Vitiligo: A Nationwide Population-Based Cohort Study." Journal of Clinical Oncology 37, no. 11 (2019): 903–11. http://dx.doi.org/10.1200/jco.18.01223.

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PURPOSE Recent studies indicated that the autoimmunity of vitiligo exerts effects on cells other than melanocytes, which confer reduced risks of both melanoma and nonmelanoma skin cancers in patients with vitiligo. However, the risk of internal malignancy in patients with vitiligo has not been elucidated. PATIENTS AND METHODS We conducted a population-based retrospective cohort study using data from the Korean National Health Insurance claims database obtained from January 2007 to December 2016. All patients age 20 years or older with vitiligo who had at least two contacts with a physician fro
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Kemp, E. Helen, Elizabeth A. Waterman, and Anthony P. Weetman. "Immunological pathomechanisms in vitiligo." Expert Reviews in Molecular Medicine 3, no. 20 (2001): 1–22. http://dx.doi.org/10.1017/s1462399401003362.

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Vitiligo is a depigmenting disorder characterised by the loss of melanocytes from the cutaneous epidermis. Although the exact aetiology of vitiligo has not yet been established, the abnormal immune responses frequently observed in vitiligo patients have led to the suggestion that, in some cases, the condition has an autoimmune component. Briefly, circulating autoantibodies and autoreactive T cells that recognise pigment cell antigens have been detected in the sera of a significant proportion of vitiligo patients compared with healthy individuals. In addition, vitiligo is often associated with
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Vachiramon, Vasanop, Sarawin Harnchoowong, Woranit Onprasert, and Kumutnart Chanprapaph. "Prevalence of Thyroid Abnormalities in Thai Patients with Vitiligo." BioMed Research International 2017 (2017): 1–6. http://dx.doi.org/10.1155/2017/7502935.

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Background. Vitiligo is an acquired hypopigmentary disorder. The prevalence of vitiligo is 0.1–2% worldwide. Numerous autoimmune diseases are associated with vitiligo, including autoimmune thyroid diseases. The prevalence of thyroid abnormalities is up to 34% in vitiligo patients depending on ethnicities. Objective. This study aims to investigate thyroid abnormalities in Thai patients with vitiligo. Methods. Medical records of vitiligo patients attending outpatient dermatology clinic at a university-based hospital from 2012 to 2016 were retrospectively reviewed. Data regarding vitiligo, clinic
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Nazar, Iqra, Fatima Kamran, and Afsheen Masood. "Psychosocial Predictors of Quality of Life in Patients With Vitiligo." Pakistan Journal of Psychological Research 36, no. 1 (2021): 19–36. http://dx.doi.org/10.33824/pjpr.2021.36.1.02.

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The present study was designed to examine psychosocial predictors of quality of life (QoL) such as body image, self-esteem, impact of Vitiligo (psychologically and socially), and perceived stigmatization in patients with Vitiligo. The sample (N =120) comprised of individuals with Vitiligo recruited from dermatology units of different hospitals in Lahore. Body Image State Scale (Cash, Fleming, Alindogan, Steadman, & Whitehead 2002), Rosenberg Self-Esteem Scale (Rosenberg, 1965), Vitiligo Impact Scale (Rammam, Khaitan, Mehta, Sreenivas, & Gupta, 2014), Perceived Stigmatization Questionna
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Hasibuan, Dina R. U., Imam B. Putra, and Nelva K. Jusuf. "Correlation between Serum Homocysteine and Vitiligo Area Scoring Index." Open Access Macedonian Journal of Medical Sciences 5, no. 3 (2017): 332–34. http://dx.doi.org/10.3889/oamjms.2017.066.

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Background: Vitiligo is a chronic skin disorder. White macules caused by melanocyte destruction is a characteristic finding that cosmetically disturbing. Until recently, pathogenesis of vitiligo is still unclear. The role of homocysteine in vitiligo is mentioned in previous studies thus it is probable that it can be a biomarker to determine vitiligo severity. Aim : To determine correlation between serum homocysteine and vitiligo area scoring index (VASI)Subject and method: This was a cross-sectional analytic study which involved 30 vitiligo patients that were diagnosed by clinical and Wood’
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14

Khurrum, Huma, and Khalid M. AlGhamdi. "The Relationship Between the Serum Level of Vitamin D and Vitiligo." Journal of Cutaneous Medicine and Surgery 20, no. 2 (2015): 139–45. http://dx.doi.org/10.1177/1203475415610071.

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Background: Low vitamin D levels have been associated with several autoimmune diseases. Vitiligo could be associated with low vitamin D levels. Objective: To determine the level of serum vitamin D in vitiligo patients compared to controls and reveal the possible association of vitamin levels with the pathogenesis of vitiligo. Patients and Methods: A case-controlled study was conducted. After excluding factors that may affect serum vitamin D levels, blood samples were taken from vitiligo patients and controls. The association between vitamin D levels and various vitiligo subgroups (duration of
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Salim, Yessy Farina, and Sri Lestari. "Terapi bedah pada vitiligo." Majalah Kedokteran Andalas 41, no. 2 (2018): 88. http://dx.doi.org/10.25077/mka.v41.i2.p88-93.2018.

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Vitiligo merupakan suatu gangguan pigmentasi kulit didapat, ditandai dengan adanya makula hipopigmentasi berwarna putih susu berbatas tegas disebabkan oleh hilangnya fungsi melanosit secara kronik dan progresif dari epidermis. Vitiligo merupakan penyakit multifaktorial, gangguan poligenik, dengan patogenesis yang masih belum jelas. Tujuan pengobatan adalah terhentinya progresifitas penyakit dan peningkatan repigmentasi. Terdapat tiga pola mekanisme repigmentasi pada vitiligo antara lain berawal dari unit folikel rambut (perifolikular), meluas dari tepi (marginal), dan difusa. Terdapat beberapa
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Niang, S. O., Maodo Ndiaye, Fatimata Ly, et al. "The Vitiligo in Senegal." ISRN Dermatology 2012 (January 11, 2012): 1–3. http://dx.doi.org/10.5402/2012/932163.

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The aim of our study was to determine the epidemiological and clinical aspects of vitiligo in the largest dermatology department of Senegal. A cross-sectional and descriptive study in a period of 5 months was performed covering all the vitiligo cases. Fifty patients were identified (26 women and 24 men). The mean age was 26.5 years. A family history of vitiligo was found in 11 cases and a psychoaffective disturbance in 6 cases. The clinical forms distinguished were generalized vitiligo (), localized vitiligo (), vitiligo universalis (), and segmental vitiligo (). The Koebner phenomenon was fou
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Alshiyab, Diala M., Firas A. Al-qarqaz, Leen H. Heis, Jihan M. Muhaidat, Wlla S. Eddin, and Ausama A. Atwan. "Assessment of Serum Vitamin D Levels in Patients with Vitiligo in Jordan: A Case-Control Study." Dermatology Research and Practice 2019 (October 10, 2019): 1–4. http://dx.doi.org/10.1155/2019/2048409.

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Background. Low vitamin D serum levels have been associated with many autoimmune disorders and several other skin diseases. Vitiligo is an autoimmune disease characterized by destruction of melanocytes by immune mechanisms. Melanocytes express vitamin D receptors, and their function can be affected by vitamin D status. Objectives. The main objective of this study is to compare vitamin D levels in patients with vitiligo vs normal population and whether vitamin D deficiency is associated with vitiligo. Methods. A case-control study was conducted. 100 vitiligo patients and 100 as controls were in
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Vachiramon, Vasanop, Woranit Onprasert, Sarawin Harnchoowong, and Kumutnart Chanprapaph. "Prevalence and Clinical Characteristics of Itch in Vitiligo and Its Clinical Significance." BioMed Research International 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/5617838.

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Objective. Vitiligo usually presented as asymptomatic depigmented macules and patches. Little is known regarding itch in vitiligo. This study aimed to evaluate the prevalence and characteristics of itch in vitiligo patients. Patients and Methods. A cross-sectional study was conducted on vitiligo patients. Itch character and intensity were determined through questionnaires. Evaluation was also made by dermatologists to define vitiligo subtype, body surface area, Koebner phenomenon (KP), and so on. Data were assessed by computer software. Results were considered statistically significant if p&lt
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Lazzeri, L., R. Colucci, A. Cammi, F. Dragoni, and S. Moretti. "Adult Onset Vitiligo: Multivariate Analysis Suggests the Need for a Thyroid Screening." BioMed Research International 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/8065765.

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Background. There are limited epidemiological studies evaluating the effect of age at onset on disease features in vitiligo.Objectives. To identify factors associated with adult onset vitiligo in comparison with childhood onset vitiligo.Patients and Methods. We retrospectively collected medical records of 191 patients. Such records included clinical examination, personal and familial medical history, laboratory evaluations, concomitant vitiligo treatment and drug assumption.Results. 123 patients with a disease onset after the age of 40 (adult onset vitiligo) were compared with 68 patients who
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Mulekar, Sanjeev V., Ahmed Al Issa, Marwan Asaad, Bassel Ghwish, and Abdullah Al Eisa. "Mixed Vitiligo." Journal of Cutaneous Medicine and Surgery 10, no. 2 (2006): 104–7. http://dx.doi.org/10.2310/7750.2006.00018.

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Background: There are two commonly recognized forms of vitiligo—generalized and localized. This classification is important to understand the course of the disease and its prognosis. Most patients have generalized vitiligo; few patients have both segmented and generalized vitiligo. Observation: We report four more cases of mixed vtiligo, segmental with generalized type. This report is only the second to present a case of segmental with generalized vitiligo. Conclusion: Mixed vitiligo is not yet part of a standard classification. Its etiology is not yet fully defined. Further research is requir
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Tsadik, Afewerki Gebremeskel, Goitom Fitsum Legesse, Desilu Mahari Desta, Brhane Teklebrhan Assefa, Hailekiros Gebretsadik Kidanemariam, and Meles Tekie Gidey. "Clinico-Epidemiological Profile and Treatment Pattern of Vitiligo in Selected Dermatological Clinics of Mekelle City, Northern Ethiopia." Dermatology Research and Practice 2020 (May 30, 2020): 1–6. http://dx.doi.org/10.1155/2020/3625753.

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Background. Vitiligo is not a well-studied disease in Ethiopia. Therefore, this study assessed its clinico-epidemiological profile and treatment patterns. Methods. An institutional-based cross-sectional study was conducted in conveniently selected dermatologic clinics of Mekelle city, Ethiopia. A two-phased study was conducted, in which the first was to determine prevalence of vitiligo while the second phase was to describe the clinico-epidemiological profile and treatment pattern of vitiligo. Four-hundred three randomly selected dermatological patients were included in the first phase study.
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Yazdanpanah, Mohammad Javad, Seyed Ali Seyedi Noghabi, Morteza Taghavi, Monavar Afzal Aghaee, and Naghmeh Zabolinejad. "Comparison of Autoimmune Thyroid Disease in Patients With Progressive and Stable Vitiligo." Journal of Cutaneous Medicine and Surgery 20, no. 2 (2015): 135–38. http://dx.doi.org/10.1177/1203475415604551.

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Background and Objective: Activity of vitiligo has not been considered as a patient selection criteria in previous studies; we decided to compare the presence of elevated thyroid auto-antibodies in patients with progressive and stable vitiligo. Methods: Seventy-two patients with vitiligo were examined for thyroid problems and were divided into 2 groups of stable and progressive vitiligo according to their history and physical examination. Anti-thyroid peroxidase antibodies (anti-TPO antibodies), thyroxine (T4), and thyroid stimulating hormone (TSH) levels were assessed for all patients. Result
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Karam, Rehab A., Haidy E. Zidan, and Mohamed H. Khater. "Genetic variants of interferon-gamma and its mRNA expression and inflammatory parameters in the pathogenesis of vitiligo." Biochemistry and Cell Biology 95, no. 4 (2017): 474–81. http://dx.doi.org/10.1139/bcb-2016-0228.

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Although genetics plays an essential role in the pathogenesis of vitiligo, vitiligo pathogenesis is still unclear. Our aim was to investigate the role of IFN-γ expression and polymorphism in vitiligo susceptibility and whether intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor (TNF)-α, and TNF-β play a role in vitiligo pathogenesis as important inflammatory parameters. Eighty-five patients with vitiligo and 90 controls were investigated for IFN-γ gene expression by quantitative real-time PCR and genotyped for IFN-γ +874T/A (rs2430561) and IFN-γ +2109A/G (rs1861494) gene polymorp
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Le, Thai Van Thanh, Huy Ngoc Phan, Tran Ngoc Dang, and Le Duy Pham. "Increased Circulatory Interleukin-17A Levels in Patients with Progressive and Leukotrichial Vitiligo." Dermatology Research and Practice 2021 (April 21, 2021): 1–7. http://dx.doi.org/10.1155/2021/5524566.

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Background. Vitiligo is a chronic condition characterized by skin depigmentation. Although not life-threatening, it significantly impacts quality of life. The pathophysiology of vitiligo remains poorly understood, and treatment options are limited. Mounting evidence supports the importance of autoreactive T cells and, particularly interleukin-17A- (IL-17A-) secreting Th17 cells, in vitiligo. IL-17A targeting has been proven successful in various inflammatory dermatological conditions, including psoriasis and lupus erythematosus. Objective. We evaluated the relationship between serum levels of
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Burlando, Martina, Andrea Muracchioli, Emanuele Cozzani, and Aurora Parodi. "Psoriasis, Vitiligo, and Biologic Therapy: Case Report and Narrative Review." Case Reports in Dermatology 13, no. 2 (2021): 372–78. http://dx.doi.org/10.1159/000514198.

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Psoriasis and vitiligo are 2 multifactorial immune-mediated diseases, partially sharing pathogenetic underpinnings. Their coexistence in the same patient, although uncommon, is documented in the literature. Further, several cases of vitiligo induced by biological drugs in psoriatic patients are reported. However, improvements in psoriasis and pre-existing vitiligo after the introduction of biological therapy are also described. To date, anti-TNF-alpha is the most cited group of biological drugs that induce new-onset vitiligo or progression of pre-existence vitiligo in psoriatic patients. Even
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Alghamdi, Khalid M., Noura A. Moussa, Ahmed Mandil, et al. "Public Perceptions and Attitudes Toward Vitiligo." Journal of Cutaneous Medicine and Surgery 16, no. 5 (2012): 334–40. http://dx.doi.org/10.1177/120347541201600510.

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Background: Previous studies have discussed attitudes of vitiligo patients toward their disease. However, no studies have addressed this issue from the public's point of view. Objective: To explore the perceptions, attitudes, and misconceptions of the public toward vitiligo. Methods: A self-administered questionnaire was distributed to attendees of primary health care centers in Riyadh, Saudi Arabia, between January and August 2010. Results: Overall, 924 of the 1,000 distributed questionnaires were returned, and 429 were males (46.8%). Moreover, 33.1% (303 of 916) believed that vitiligo is con
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Fernandes, Nurimar Conceição, and Márcia Maria Cajueiro Campos. "Vitiligo na criança e doença da tireóide." Anais Brasileiros de Dermatologia 84, no. 2 (2009): 200–202. http://dx.doi.org/10.1590/s0365-05962009000200017.

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A associação entre vitiligo e tireoidopatia na criança é discutível. Cinquenta crianças com vitiligo e 40 sem vitiligo foram submetidas às dosagens séricas de anticorpos antitireoide e hormônio tireoestimulante. Um caso (grupo teste) e um caso controle mostraram títulos de TSH acima do limite normal; o vitiligo não representou maior risco para tireoidopatia.
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Hann, Seung-Kyung, Dunlu Chen, and Jean-Claude Bystryn. "Systemic Steroids Suppress Antimelanocyte Antibodies in Vitiligo." Journal of Cutaneous Medicine and Surgery 1, no. 4 (1997): 193–95. http://dx.doi.org/10.1177/120347549700100403.

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Background: Vitiligo is associated with autoantibodies to melanocytes. The role of these antibodies in the pathogenesis of the disease is still unknown. Objective: The purpose of this study was to examine the role of vitiligo antibodies in the pathogenesis of the disease by studying whether or not there is a correlation between changes in their level and response to therapy with systemic steroid. Methods: Antibodies to the 40 to 45 kD, 75 kD, and 90 kD vitiligo antigens were measured prior to and following systemic steroid therapy in 10 patients with active vitiligo. Results: Four months follo
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Kanwar, Amrinder J., Rahul Mahajan, and Davinder Parsad. "Effect of Age at Onset on Disease Characteristics in Vitiligo." Journal of Cutaneous Medicine and Surgery 17, no. 4 (2013): 253–58. http://dx.doi.org/10.2310/7750.2013.12075.

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Background: Vitiligo is a multifactorial disease in which genetic, immunologic, and environmental factors play an important part. Late-onset vitiligo is a poorly defined entity. Materials and Methods: Case records of patients who attended the pigmentary clinic at our institute from January 2001 to December 2010 were reviewed. Patients with a diagnosis of vitiligo were analyzed with respect to their demographic characteristics with special reference to their age at onset. Results: Patients with disease onset after 30 years had a significantly higher association with precipitating factors such a
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Tsadik, Afewerki Gebremeskel, Mezgebe Zeru Teklemedhin, Tesfay Mehari Atey, Meles Tekie Gidey, and Desilu Mahari Desta. "Public Knowledge and Attitudes towards Vitiligo: A Survey in Mekelle City, Northern Ethiopia." Dermatology Research and Practice 2020 (May 31, 2020): 1–7. http://dx.doi.org/10.1155/2020/3495165.

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Background. The overall well-being, sense of stigmatization, and treatment outcome of persons with vitiligo are largely dependent on their social acceptance and this is linked with perception and attitude of this disease in a given population. Therefore, this study assessed the knowledge and attitude of the public towards vitiligo. Methods. A cross-sectional survey was carried out using a self-reported questionnaire distributed to adults living in Mekelle city, Northern Ethiopia from August to November 2019. Individuals who were 18 to 65 years of age and not suffering from vitiligo were includ
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Davletshina, Alina Yu, and K. M. Lomonosov. "PROSPECTIVE METHODS OF VITILIGO TREATMENT (LITERATURE REVIEW)." Russian Journal of Skin and Venereal Diseases 22, no. 1-2 (2019): 56–60. http://dx.doi.org/10.17816/dv42938.

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A systematic review of modern methods of treatment of vitiligo is presented. Treatment of vitiligo is a difficult task. The data of various studies are shown. It has been revealed that during the treatment of associated diseases, positive effects of vitiligo in the form of pigmentation recovery from some drugs are noticed. Therefore, many drugs are considered not only as promising vitiligo treatment, but also as independent. The purpose of this article is to update information in the treatment of vitiligo, including existing and new methods.
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Nunes, Daniel Holthausen, and Ligia Maria Hademann Esser. "Perfil epidemiológico dos pacientes com vitiligo e sua associação com doenças da tireoide." Anais Brasileiros de Dermatologia 86, no. 2 (2011): 241–48. http://dx.doi.org/10.1590/s0365-05962011000200006.

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FUNDAMENTO: O vitiligo é considerado a hipomelanose adquirida mais frequente. Apesar de sua etiopatogenia ser incerta, acredita-se que a etiologia autoimune seja a mais plausível, teoria que se fundamenta na concomitância de vitiligo com doenças autoimunes. OBJETIVOS: Traçar o perfil epidemiológico dos pacientes com vitiligo e estimar a prevalência da associação de vitiligo com doenças autoimunes da tireoide. MÉTODOS: Efetuou-se um estudo transversal, analisando-se prontuários dos pacientes com diagnóstico de vitiligo atendidos no Ambulatório de Dermatologia AME-Unisul e do HU-UFSC. Avaliaram-
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Deng, Qiancheng, Jingchao Wei, Puyu Zou, et al. "Transcriptome Analysis and Emerging Driver Identification of CD8+ T Cells in Patients with Vitiligo." Oxidative Medicine and Cellular Longevity 2019 (November 26, 2019): 1–15. http://dx.doi.org/10.1155/2019/2503924.

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Activated CD8+ T cells play important roles in the pathogenesis of vitiligo. However, driving factors about the activation and migration of CD8+ T cells remain obscure. In this study, we aim to identify differentially expressed genes (DEGs) and uncover potential factors that drive the disease in melanocyte-specific CD8+ T cells in vitiligo. A total of 1147 DEGs were found through transcriptome sequencing in CD8+ T cells from lesional skin of vitiligo patients and normal controls. Based on KEGG pathway enrichment analysis and PPI, 16 upregulated and 23 downregulated genes were identified. Ultim
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Kussainova, Assiya, Laura Kassym, Almira Akhmetova, et al. "Vitiligo and anxiety: A systematic review and meta-analysis." PLOS ONE 15, no. 11 (2020): e0241445. http://dx.doi.org/10.1371/journal.pone.0241445.

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Background Vitiligo is an acquired depigmenting skin disease which is often accompanied by mental distress. There are numerous studies dedicated to local and global prevalence of depression in patients with vitiligo but anxiety has not been recognized as a major mental problem within named population. We aimed to evaluate the prevalence of anxiety among patients with vitiligo from different countries and to compare it with patients suffering from eczema, psoriasis, and acne. Methods In November 2019, we conducted a systematic search for observational studies that examined the prevalence of anx
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Yu, Richard, Yuanshen Huang, Xuejun Zhang, and Youwen Zhou. "Potential Role of Neurogenic Inflammatory Factors in the Pathogenesis of Vitiligo." Journal of Cutaneous Medicine and Surgery 16, no. 4 (2012): 230–44. http://dx.doi.org/10.1177/120347541201600404.

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Background: Vitiligo is a highly complex multifactorial condition of the skin that has an unclear mechanism of pathogenesis. Objective: This review summarizes the role of various neurogenic inflammatory factors significantly upregulated in vitiligo. Methods: A literature review was conducted of all pertinent data regarding neuropeptides that are altered in vitiligo and their possible role in the destruction of melanocytes. Results: The close associations between the skin, immune system, and nervous system, along with specific changes demonstrated in vitiligo patients, support a pathogenic mech
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Iqbal, Arsheed, Adil Rashid, Afroza Jan, and Haider . "Efficacy of leeching (Ta‘līq al-‘Alaq) in patients with vitiligo (baras): a comprehensive case study." International Journal of Basic & Clinical Pharmacology 10, no. 9 (2021): 1143. http://dx.doi.org/10.18203/2319-2003.ijbcp20213371.

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Vitiligo is a hypomelanotic skin disorder in white patches appear on the skin surface and also involve the hair. The disease is idiopathic, acquired and effects 1-4 percent of the world population. It is belived that there is immunologic influence in the pathogenesis of vitiligo and there is evidence of early cell death in vitiligo melanocytes related to their increased sensitivity to oxidative stress. In Ayurveda the vitiation of three doshas results deraignment of rasa, rakta, mamsa and medadhuta which results in vitiligo patches on skin. In Unani System of Medicine (USM) the deraignment of
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Khurrum, Huma, Khalid M. AlGhamdi, and Essam Osman. "Screening of Glaucoma or Cataract Prevalence in Vitiligo Patients and Its Relationship With Periorbital Steroid Use." Journal of Cutaneous Medicine and Surgery 20, no. 2 (2015): 146–49. http://dx.doi.org/10.1177/1203475415615325.

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Background/Aim: There is scarce literature connecting vitiligo and primary open angle glaucoma (POAG). Most literature reports that secondary complications are a direct consequence of corticosteroid treatment of vitiligo. In this study, we aimed to investigate the prevalence of ocular problems in patients with vitiligo and to determine its association with periorbital topical corticosteroid use. Method: A cross-sectional study was carried out on 90 patients with vitiligo. The Vitiligo European Task Force questionnaire was completed for each patient. A control group comprising 90 healthy indivi
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Abdulaziz Murad, Manal, Hoda Jehad Abousada, Abdulelah Hassan Alluhaybi, et al. "PREVALENCE OF VITILIGO IN KINGDOM OF SAUDI ARABIA (CROSS SECTIONAL STUDY)." International Journal of Advanced Research 8, no. 12 (2020): 900–905. http://dx.doi.org/10.21474/ijar01/12231.

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Background:Vitiligo is acquired condition of skin and hair depigmentation that characterized by the appearance of pale macules or hypochromic pigment. Vitiligo is not a life-threatening situation however it affects patients health-related quality of life and psychological well-being. Therefore, in this study, we aimed to prevalence of vitiligo in Saudi population besides, Most common place of first spot of vitiligo, and the relationship between some medical conditions and vitiligo. Methodology: This is an analytical cross-sectional study conducted in kingdom of Saudi Arabia (General population
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Ranaivo, I. M., F. A. Sendrasoa, M. Andrianarison, et al. "Vitiligo Associated with Melanoma in a Malagasy Woman." Case Reports in Dermatological Medicine 2019 (November 11, 2019): 1–3. http://dx.doi.org/10.1155/2019/7925785.

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Malignant melanoma is the first fatal skin cancer. Vitiligo is a leukoderma or a multifactorial depigmentation acquired but especially of autoimmune origin. We report the first Malagasy case affected by both melanoma and Vitiligo. The appearance of Vitiligo during a melanoma could testify to an immunological response against melanocytes. Despite the association of melanoma and Vitiligo, the prognosis of melanoma is still fatal.
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Jusuf, Nelva Karmila, Imam Budi Putra, and Dina Rizki Utami. "Quality of Life in Vitiligo Patients at H. Adam Malik General Hospital Medan, Indonesia." Sumatera Medical Journal 1, no. 1 (2018): 41–48. http://dx.doi.org/10.32734/sumej.v1i1.445.

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Abstract. Background: Vitiligo is an acquired depigmenting skin disorder that can affect the patients’ quality of life (QOL). Objectives: The aim of this study was to evaluate the QOL in patients with vitiligo. Methods: This study included 30 patients with vitiligo. All the patients filled out questionnaires Skindex- 29. Data were compiled and analyzed statistically. Results: Among the 30 vitiligo patients, 73,3 % were women and 26,7 % were men. Mean age of patients were 40.53 ± 12. 91 years old. The mean duration of vitiligo was 9.07 ± 7.643 years. The mean total Skindex-29 score of the subje
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Mahjour, Marjan, and Arash Khoushabi. "A Review Article About Some Herbs Affecting Vitiligo Based on Avicenna’s Canon." Current Drug Discovery Technologies 17, no. 2 (2020): 133–37. http://dx.doi.org/10.2174/1570163815666181017100847.

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Background: Vitiligo is a pigmentary disorder characterizing by white macules due to loss of melanocytes. Vitiligo affects about 1 to 4% of people around the world. The treatment of vitiligo has a high cost and the long process of treatment in spite of no complete remedy. It has various psychological side-effects such as depression and anxiety affecting the quality of life seriously. Avicenna in his Canon treated these patients over a thousand years ago. This study aimed to introduce some herbal drugs in vitiligo based on the Canon of Avicenna besides the conventional medical treatments. Metho
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Castro, Caio César Silva de. "Prevalência de psoríase em estudo de 261 pacientes com vitiligo." Anais Brasileiros de Dermatologia 80, no. 5 (2005): 489–92. http://dx.doi.org/10.1590/s0365-05962005000600006.

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FUNDAMENTOS: O estudo da associação de psoríase e vitiligo é necessário em razão das prováveis origens imunológicas dessas enfermidades e da proximidade de loci encontrados no cromossomo 1p31. OBJETIVO: O propósito principal foi determinar a prevalência de psoríase em pacientes com vitiligo em amostra de 740 pacientes submetidos à fototerapia em Curitiba, PR e descrever suas características clínicas. MÉTODOS: Dos 740, foram estudados retrospectivamente 261 pacientes com diagnóstico de vitiligo, e analisados aqueles com associação de vitiligo e psoríase no período entre 2000 e 2004. RESULTADOS:
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Choi, Chong Won. "Non-surgical treatment of vitiligo." Journal of the Korean Medical Association 63, no. 12 (2020): 741–47. http://dx.doi.org/10.5124/jkma.2020.63.12.741.

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Vitiligo is an acquired depigmenting skin disorder that affects 0.5% to 2% of the population. Skin lesions from vitiligo, white macules and patches on the skin, can pose a substantial psychological burdencan, causing a significant decrease in one’s quality of life. Recent basic and clinical studies have found that vitiligo is an autoimmune disorder, mediated by CD8+ T-cell and interferon-γ-mediated cytokine/chemokines. Although no treatment modality presents a complete cure for vitiligo, current treatment modalities have a modest effect on vitiligo by reversing the disease’s progression, induc
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Anaba, Ehiaghe L., Adekunle O. George, and Adebola O. Ogunbiyi. "Epidemiology and clinical profile of vitiligo in Ibadan, Nigeria." International Journal of Research in Medical Sciences 6, no. 12 (2018): 3801. http://dx.doi.org/10.18203/2320-6012.ijrms20184873.

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Background: Vitiligo patients are seen routinely in the Dermatology Outpatient Clinic of the University College Hospital Ibadan, Nigeria. However, the epidemiologic and clinical profile of these patients is not documented. The aim of this study was to document the clinical (age of onset, location, severity, class of vitiligo) and sociodemographic characteristics of these patients.Methods: This is a retrospective descriptive study of patients treated for vitiligo from January 2005 to December 2009 at the University College Hospital (UCH) Ibadan dermatology outpatient clinic. Patient records wer
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Souza Filho, Luiz Gonzaga C., Evandro A. Rivitti, Lucy M. Miyauchi, et al. "Estudo comparativo entre vitiligo, nevo halo e lúpus eritematoso vitiligóide por meio de métodos imunológicos, histológicos e imuno-histoquímicos." Anais Brasileiros de Dermatologia 80, no. 2 (2005): 143–48. http://dx.doi.org/10.1590/s0365-05962005000200004.

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FUNDAMENTOS: O estudo compara o vitiligo, o nevo halo (NH) e lúpus eritematoso vitiligóide (LEV) do ponto de vista imunológico, histológico e histoquímico. OBJETIVOS: Avaliar diferenças imuno-histoquímicas entre essas doenças e investigar se a despigmentação do LEV deve-se à destruição pós-inflamatória ou à agressão imunológica aos melanócitos. MÉTODOS: Foram avaliados 20 pacientes com vitiligo, 17 com vitiligo e NH, cinco com NH isolado e 15 com LEV. Detecção de anticorpos: IF direta e indireta com células névicas e de melanoma. Citotoxicidade: atividade NK contra células de melanoma. Estudo
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Veiga-Castelli, Oliveira, Pereira, et al. "HLA-G Polymorphisms Are Associated with Non-segmental Vitiligo among Brazilians." Biomolecules 9, no. 9 (2019): 463. http://dx.doi.org/10.3390/biom9090463.

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(1) Background: Vitiligo is characterized by white patches on the skin caused by loss of melanocyte activity or the absence of these cells. The available treatments minimize the symptoms by retarding the process of skin depigmentation or re-pigmenting the affected regions. New studies are required for a better comprehension of the mechanisms that trigger the disease and for the development of more efficient treatments. Studies have suggested an autoimmune feature for vitiligo, based on the occurrence of other autoimmune diseases in vitiligo patients and their relatives, and on the involvement
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47

Hung, Chih-Tsung, Hsin-Hui Huang, Chun-Kai Wang, et al. "Pregnancy outcomes in women with vitiligo: A Taiwanese nationwide cohort study." PLOS ONE 16, no. 3 (2021): e0248651. http://dx.doi.org/10.1371/journal.pone.0248651.

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Vitiligo is perceived as an autoimmune skin disease. Previous studies showed conflicting data about vitiligo and pregnancy outcomes. To delineate the associations between vitiligo and the pregnancy outcomes, we used the National Health Insurance Research Database of Taiwan to conduct a retrospective cohort study from January 1, 2000 to December 31, 2015. This study population was composed of 1,096 women with vitiligo and 4,384 women without vitiligo, who were all matched according to age, comorbidity, and index year. Compared with the non-vitiligo controls, women with vitiligo had a higher ris
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Sundar, Priya Kootelu, Bindu Mohan Chavala, Shanmukha Miyatura Nagaraj, and Harshitha Kotla Reddy. "A Study of Serum Levels of Vitamin B12, Folic Acid, and Homocysteine in Vitiligo Patients and Controls Attending a Tertiary Care Hospital in Bengaluru – An Analytical Cross-Sectional Study." Journal of Evolution of Medical and Dental Sciences 10, no. 30 (2021): 2271–75. http://dx.doi.org/10.14260/jemds/2021/464.

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BACKGROUND Vitiligo is a hypopigmentary disease of the skin which is associated with impaired quality of life and depression. In our present study, we evaluated the serum levels of homocysteine, vitamin B12, and folic acid in patients with vitiligo and controls in a tertiary care centre and also their association with the extent and activity of vitiligo. METHODS An analytical cross-sectional study was conducted on 40 patients with vitiligo and 40 controls visiting a tertiary care centre for a period of one year. Detailed history regarding demographic data, history of disease, family history, d
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Tuna, A., G. Ozturk, TB Gerceker, et al. "Superoxide dismutase 1 and 2 gene polymorphism in Turkish vitiligo patients." Balkan Journal of Medical Genetics 20, no. 2 (2017): 67–73. http://dx.doi.org/10.1515/bjmg-2017-0033.

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Abstract Vitiligo is an acquired disease of unknown etiology. Several theories have been proposed to understand the pathogenesis. The role of oxidative stress has been getting more important in recent years. One of the primary antioxidant enzymes in vitiligo is the superoxide dismutase (SOD). The aim of this study is to investigate the polymorphisms of the SOD1 and SOD2 in Turkish vitiligo patients. One hundred one vitiligo patients and 99 healthy controls without family history of vitiligo were included into the study. The SOD1 35 A/C and SOD2 A16V (C/T) polymorphisms were analyzed by polymer
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Colucci, Roberta, Rossana Conti, Federica Dragoni, et al. "Evidence of a possible therapeutic role of vitamin D in a cohort of adult Caucasian vitiligo patients." International Journal for Vitamin and Nutrition Research 90, no. 3-4 (2020): 200–204. http://dx.doi.org/10.1024/0300-9831/a000605.

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Abstract. Reduced serum 25(OH)D levels have been largely reported in vitiligo, which is an autoimmune skin disorder characterized by the appearance of achromic macules. Since vitamin D can positively modulate immune function and stimulate melanogenesis in vitro, a possible role of sufficient vitamin D levels in promoting the stability of the disease and repigmentation process might be hypothesized in vitiligo. Hence, we conducted an observational study on medical records related to 101 vitiligo patients, in order to correlate baseline 25(OH)D levels with the baseline vitiligo activity and repi
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