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Journal articles on the topic 'VKH'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Sato, Tomohito, Nanae Taniguchi, Yoshiaki Nishio, Masataka Ito, and Masaru Takeuchi. "Classification of Peripheral Blood Leukocyte Phenotypes and Serum Cytokines in Vogt–Koyanagi–Harada Disease before and after Glucocorticoid Therapy." Journal of Clinical Medicine 12, no. 24 (2023): 7742. http://dx.doi.org/10.3390/jcm12247742.

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Vogt–Koyanagi–Harada disease (VKH) is an autoimmune disease, and glucocorticoid therapy (GC) is widely used for VKH. We provided a profile of leukocyte populations and serum cytokines in VKH patients under GC. A prospective observational study was conducted on three treatment-naïve VKH patients. Peripheral blood samples were collected from the patients before GC (VKH-acute) and after 6 months (VKH-remission), and healthy individuals were used as controls. Proportions of 37-type leukocytes and levels of 27-kind cytokines were measured by mass cytometry and multiplex bead analysis. Property simi

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Gupta, Chanda, Aditi Singal, and Manisha Agarwal. "Comparison of Optical Coherence Tomography Features of Vogt–Koyanagi–Harada Disease and Central Serous Chorioretinopathy." Delhi Journal of Ophthalmology 35, no. 2 (2025): 120–24. https://doi.org/10.4103/dljo.dljo_118_24.

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Purpose: The purpose of the study was to compare and analyze the optical coherence tomography (OCT) features of Vogt–Koyanagi–Harada disease (VKH) and central serous chorioretinopathy (CSCR). Materials and Methods: A retrospective review of OCT records was done for eyes with VKH and CSCR. We enrolled 50 eyes that presented to us with CSCR and 35 eyes with VKH. Various OCT features were analyzed using a two-tailed Z test between the two diseases. P <0.05 was considered to be statistically significant. Results: The mean age of patients with VKH was 37.0 ± 8.2 (21–49) years, and patients with

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Kumar, Dhivya Ashok, Jiji P. Vijayan, and Amar Agarwal. "Vogt–Koyanagi–Harada-like presentation: A short case series." Indian Journal of Ophthalmology - Case Reports 4, no. 1 (2024): 192–96. http://dx.doi.org/10.4103/ijo.ijo_719_23.

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We report a short case series of Vogt–Koyanagi–Harada (VKH)-like presentation in the eyes of Indian patients following vaccination. Patients with symptoms and signs of VKH that developed after coronavirus disease 2019 (COVID-19) vaccination, who presented with the first episode of the disease were included. There were five patients with four probable VKH and one incomplete VKH, with the mean time of onset being 5.4 ± 3.7 weeks. All patients had bilateral presentation. Steroid treatment was effective with no recurrence. Any vaccination can act as a trigger for the first episode of VKH presentat

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Manni, Priscilla, Maria Carmela Saturno, and Massimo Accorinti. "Vogt-Koyanagi-Harada Disease and COVID." Journal of Clinical Medicine 12, no. 19 (2023): 6242. http://dx.doi.org/10.3390/jcm12196242.

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Vogt–Koyanagi–Harada (VKH) is a rare multisystem inflammatory disease affecting the eyes, ears, brain, skin, and hair. The Coronavirus Disease 2019 (COVID-19) is a new contagious infection that might trigger the onset of VKH disease, as previously proposed for other viruses. Moreover, after the mass vaccination against SARS-CoV-2 worldwide, cases of VKH disease associated with COVID-19 vaccination have been reported. We present an overview of VKH and a comprehensive literature revision of all the VKH cases described after COVID-19 infection and vaccination, adding our experience. No difference

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Park, Jae Han. "Vogt-Koyanagi-Harada Disease Presented with Bilateral Optic Disc Edema." Journal of the Korean Neurological Association 42, no. 2 (2024): 166–70. http://dx.doi.org/10.17340/jkna.2023.0092.

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Vogt-Koyanagi-Harada (VKH) disease is a multisystem inflammatory disease that occurs when body tissues including melanocytes are damaged by autoimmunity. The typical symptoms of VKH are bilateral multifocal uveitis and serous retinal detachment. Our patient was misdiagnosed as idiopathic intracranial hypertension because there were no other characteristic neurological symptoms other than bilateral optic disc edema. However, intracranial pressure was normal and pleocytosis was found, so VKH disease could be diagnosed. Bilateral optic disc edema may be a initial manifestation of VKH disease.

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Huang, Yang, Hongsong Yu, Qingfeng Cao, et al. "The Association of Chemokine Gene Polymorphisms with VKH and Behcet’s Disease in a Chinese Han Population." BioMed Research International 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/1274960.

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To investigate the association of chemokine gene polymorphisms and Behcet’s disease (BD) and Vogt Koyanagi Harada (VKH) disease in a Chinese Han population. A case-control study was performed. Three hundred and seventy-one BD patients, 371 VKH disease patients, and 605 healthy controls were recruited to determine genetic variants of 26 SNPs in 12 chemokine genes with iPLEX Gold genotyping assay and Sequenom MassARRAY or TaqMan SNP assays. In this study, Puncorr values showed a weak association of five SNPs of five genes in BD and three SNPs of three genes in VKH disease. However, after Bonferr

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Pantland, N. A., and J. H. Van Vuuren. "Die Suid-Afrikaanse uitgebreide maritieme gebied: ’n Alternatiewe metode vir die bepaling van die voet van die kontinentale helling." Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie 25, no. 4 (2006): 248–65. http://dx.doi.org/10.4102/satnt.v25i4.168.

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Kuslande het ’n eenmalige geleentheid om by die Verenigde Nasies (VN) aansoek te doen om ’n uitgebreide maritieme gebied, indien hul wetenskaplik kan toon dat die voet van die kontinentale helling (VKH) buite hul soewereine 200 seemyl eksklusiewe ekonomiese sone gele¨e is. Die VN definieer geomorfologies die VKH as die kromme van maksimale buiging tussen die afplattende kontinentale helling en die bodem van die diepsee. In hierdie artikel word daar getoon hoe gediskretiseerde tegnieke uit differensiaalmeetkunde suksesvol gebruik kan word om die VKH benaderd uit satelliet seebodem dieptedata te

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Aamri, Hasna, FZ Azzouzi, R. Elqadiry, H. Nassih, A. Bourrahouat, and I. Ait Sab. "Case Reports of Children with Vogt_Koyanagi_Harada Syndrome." Scholars Journal of Medical Case Reports 11, no. 03 (2023): 315–19. http://dx.doi.org/10.36347/sjmcr.2023.v11i03.017.

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Purpose: To assess the symptoms of Vogt-Koyanagi-Harada (VKH) syndrome in Moroccan children. Methods: Clinical data were acquired from the medical records of three children with VKH disease at the Marrakech University Children's Hospital. Results: Three cases fulfilled the VKH diagnostic criteria. The patients, ranging in age from 4 to 12 years, all had chronic illness. Uveitis was the most common ocular finding. Glaucoma, cataract, posterior synechiae, and subretinal neovascularization were complications for the patients. Conclusion: Depending on the long- term consequences, visual results we

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Eldaly, Zeiad H. "Inflammatory CNV, When Anti-Vascular Endothelial Growth Factor Is Not the Only Solution: A Case Report." Egyptian Retina Journal 11, no. 2 (2024): 32–36. https://doi.org/10.4103/erj.erj_1_25.

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Abstract Vogt–Koyanagi–Harada (VKH) disease is a multi-systemic auto-immune inflammatory disorder affecting the eye, ear, central nervous system, and integumentary system. It is characterized by bilateral granulomatous panuveitis with primary involvement of the choroidal stroma by granulomatous inflammation and Dalen-Fuch nodules. In some cases, VKH may be complicated by atrophic maculopathy or macular choroidal neovascular membrane. This case report describes a 27-year-old female initially diagnosed with idiopathic intracranial hypertension who was later found to have inflammatory choroidal n

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M Samy, Alvernia, Nor Fariza Ngah, Safinaz Mohd Khialdin, Nazila Ahmad Azli, Noor Hamidah Hussin, and Azrena Anee. "Association between HLA-DRB1*04 and Malay patients with Vogt-Koyanagi-Harada syndrome in Malaysia: A case-control study." Malaysian Journal of Ophthalmology 1, no. 2 (2019): 84–97. http://dx.doi.org/10.35119/myjo.v1i2.11.

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Introduction: Vogt-Koyanagi-Harada (VKH) is an autoimmune disorder affecting melanocyte-containing tissues. Major histocompatibility complex, class II, DR beta1 (HLA-DRB1)*04 and its suballele HLA-DRB1*0405 were found to be associated with VKH in many studies.Purpose: To determine the association of HLA-DRB1*04 and its suballele HLADRB1*0405 with VKH patients of Malay descent.Materials and methods: A case control study was conducted among VKH patients of Malay ethnicity attending Ophthalmology Clinic, Hospital Selayang, Malaysia from December 2016 to December 2017. HLA-DRB1*04 allele-specific

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Thapa, Bikram Bahadur, Shanti Gurung, Sweta Singh, and Mahesh Aryal. "Early phase Vogt-Koyanagi-Harada Disease in Nepalese Elderly woman: A case report." Nepalese Journal of Ophthalmology 12, no. 1 (2020): 146–52. http://dx.doi.org/10.3126/nepjoph.v12i1.26202.

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Introduction: Vogt–Koyanagi–Harada (VKH) disease is defined as an autoimmune disorder characterized by bilateral granulomatous panuveitis with systemic manifestations, such as tinnitus, vertigo, and meningism caused by melanocyte antigen-reactive T-cells. Majority of VKH patients present at the age between 20 and 50 years. VKH is uncommon in elderly and challenging to manage. VKH is one of the important differential diagnosis of bilateral pan uveitis Case: A 65 year/ female brought with chief complaint of sudden loss of vision in both eyes, headache and hearing problem for 1 month. She d

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Vega T., Fabián, Nathaly Elizalde A., Rodrigo A. Valenzuela B., Cristhian A. Urzua S., and Loreto Cuitiño T. "miRNAs: una nueva mirada de la enfermedad de Vogt-Koyanagi-Harada." Revista Hospital Clínico Universidad de Chile 33, no. 2 (2022): 108–19. http://dx.doi.org/10.5354/2735-7996.2022.68962.

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Vogt-Koyanagi-Harada disease (VKH) is an autoimmune multisystemic syndrome that includes bilateral intraocular inflammation, associated with exudative retinal detachments, and systemic manifestations in the auditory, integumentary, and central nervous systems. The frequency of VKH disease in the world is variable, but in Santiago, Chile, it causes approximately 17% of non-infectious uveitis, an incidence 2 to 3-fold greater than in the USA or European countries. The evidence shows that the pathogenesis of VKH would be caused by cell-mediated autoimmunity directed against melanocytes present in

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Kulchinskaya, M. A., A. S. Stoyukhina, L. Alkharki, and E. N. Korobov. "Cataracts in Fogt–Koyanagi–Harada syndrome: surgical treatment experience." Modern technologies in ophtalmology 60, no. 2 (2025): 273–74. https://doi.org/10.25276/2312-4911-2025-2-273-274.

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Relevance Vogt-Koyanagi-Harada syndrome (VKH) is a rare autoimmune disease affecting melanin-containing tissues. Uveitis, which is one of the main manifestations of VKH, is often complicated by the development of cataracts, which significantly reduces vision. Surgical treatment of cataracts in VKH requires a special approach due to the risk of postoperative complications [1–5]. Aim To describe a clinical case of successful surgical treatment of cataracts in a patient with VKH. Material and methods A clinical case of a 56-year-old patient with VKH complicated by cataracts is presented. The diag

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Palade, Dragos, Laura Otilia Damian, Doinel Radeanu, et al. "The Vogt-Koyanagi-Harada and SAPHO Syndrome: An Unusual Association." Revista de Chimie 70, no. 9 (2019): 3441–43. http://dx.doi.org/10.37358/rc.19.9.7566.

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Vogt-Koyanagi-Harada syndrome(VKH) is a multisystemic disorder characterized by granulomatous panuveitis and cutaneous, otorhynolaryngologic and neurologic involvement, due to an autoimmune reaction against melanocytic antigens. Autoinflammatory associations of VKH, including inflammatory bowel disease and psoriasis, were rarely described. SAPHO syndrome (an acronym for synovitis, acne, hyperostosis, pustulosis and osteitis) is a rare autoinflammatorymusculo-scheletal disease. This paper reports on a male patient presenting for long-lasting bone and joint pain, dysphagia,having a ten-year hist

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NAKAI, K. "OCT for VKH." Acta Ophthalmologica 91 (August 2013): 0. http://dx.doi.org/10.1111/j.1755-3768.2013.2253.x.

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AlBahkaly, Sameer, Arwa AlKhunaizi, and Zyad Algamdi. "Vogt-Koyanagi-Harada syndrome (review of case reports)." Egyptian Journal of Otolaryngology 28, no. 3 (2012): 275–77. http://dx.doi.org/10.7123/01.ejo.0000418070.27183.f7.

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AbstractVogt–Koyanagi–Harada (VKH) disease, also known as uveomeningitic syndrome, is a multisystem autoimmune disorder directed against any melanocyte-containing organ, including the eye, central nervous system, auditory, and integumentary system. We present a case of an African woman with total deafness and blindness of VKH, and discuss the histological characteristics, and review the classification and the management of VKH. The most important factor for prognosis is the immediate treatment. The rarity of this syndrome makes its diagnosis a challenge and the presence of deafness, tinnitus,

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JL, Dhanisha, Heber Anandan, Preethi Anie E, Jenesha Blessie K, and Kayal Vizhi A. "Vogt-Koyanagi Harada Syndrome: A Case Report." Greenfort International Journal of Applied Medical Science 3, no. 2 (2025): 88–91. https://doi.org/10.62046/gijams.2025.v03i02.010.

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Vogt-Koyanagi-Harada (VKH) syndrome is an autoimmune disorder characterized by bilateral eye inflammation, which can also affect the skin and nervous system. This case report describes a 49-year-old female patient who presented with blurred vision in both eyes, accompanied by poliosis and unremarkable systemic health history. Initial examination revealed significantly reduced uncorrected visual acuity, and imaging techniques including optical coherence tomography (OCT) identified optic disc edema, sub retinal fluid, and choroidal folds in both eyes. Based on the findings, the patient was diagn

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Minami, Keisuke, Mariko Egawa, Keisuke Kajita, Fumiko Murao, and Yoshinori Mitamura. "A Case of Vogt-Koyanagi-Harada Disease-Like Uveitis Induced by Nivolumab and Ipilimumab Combination Therapy." Case Reports in Ophthalmology 12, no. 3 (2021): 952–60. http://dx.doi.org/10.1159/000520416.

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Nivolumab and ipilimumab are widely used immune checkpoint inhibitors (ICPIs) for the treatment of metastatic melanoma. ICPIs cause an array of side effects called immune-related adverse events (IRAEs) due to activation of an immune response. ICPI-uveitis can cause irreversible vision loss if untreated. There are few reports of recurrent Vogt-Koyanagi-Harada (VKH) disease-like uveitis induced by nivolumab and ipilimumab. We report a case of VKH disease-like uveitis recurrence after resuming ICPIs. A 73-year-old man with advanced melanoma was referred to our clinic with visual loss 25 days afte

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Chang, Rui, Shenglan Yi, Xiao Tan, et al. "MicroRNA-20a-5p suppresses IL-17 production by targeting OSM and CCL1 in patients with Vogt-Koyanagi-Harada disease." British Journal of Ophthalmology 102, no. 2 (2017): 282–90. http://dx.doi.org/10.1136/bjophthalmol-2017-311079.

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AimTo elucidate the role of microRNA-20a-5p (miR-20a-5p) in the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease.MethodsQuantitative real-time PCR was used to quantify miR-20a-5p expression in CD4+ T cells from patients with active VKH and normal controls. The promoter methylation status of miR-20a-5p was detected by bisulfite sequencing PCR. Targets were evaluated by a luciferase reporter assay. The functional effects of miR-20a-5p on CD4+ T cells from patients with active VKH were assessed by upregulation or downregulation of its expression using liposomes.ResultsThe miR-20a-5p level was s

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Komuku, Yuki, Chiharu Iwahashi, Shinsaku Yano, Chika Tanaka, Tomoya Nakagawa, and Fumi Gomi. "En Face Optical Coherence Tomography Imaging of the Choroid in a Case with Central Serous Chorioretinopathy during the Course of Vogt-Koyanagi-Harada Disease: A Case Report." Case Reports in Ophthalmology 6, no. 3 (2015): 488–94. http://dx.doi.org/10.1159/000443264.

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Vogt-Koyanagi-Harada (VKH) disease and central serous chorioretinopathy (CSC) develop serous retinal detachment; however, the treatment of each disease is totally different. Steroids treat VKH but worsen CSC; therefore, it is important to distinguish these diseases. Here, we report a case with CSC which was diagnosed by en face optical coherence tomography (OCT) imaging during the course of VKH disease. A 50-year-old man was referred with blurring of vision in his right eye. Fundus examination showed bilateral optic disc swelling and macular fluid in the right eye. OCT showed thick choroid, an

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Fabro, Filippo, and Carl Herbort. "Need for Quantitative Measurement Methods for Posterior Uveitis: Comparison of Dual FA/ICGA Angiography, EDI-OCT Choroidal Thickness and SUN Vitreous Haze Evaluation in Stromal Choroiditis." Klinische Monatsblätter für Augenheilkunde 235, no. 04 (2018): 424–35. http://dx.doi.org/10.1055/s-0043-124966.

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Abstract Background/Purpose Quantitative methods for posterior uveitis are necessary for precise appraisal and follow-up of inflammation in practice and in clinical trials. The aim of this study was to assess fluorescein angiography (FA), indocanine green angiography (ICGA), and enhanced depth imaging optical coherence tomography choroidal thickness (EDI-OCT CT) in two stromal choroiditis entities, birdshot retinochoroiditis (BRC), and Vogt-Koyanagi-Harada disease (VKH), as well as to determine (1) disease patterns, (2) respective response to therapy, and (3) their potential utility in clinica

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Yu, Dongwoo, Tae Uk Kim, and Min Cheol Chang. "Delayed diagnosis of myelitis in a patient with Vogt-Koyanagi-Harada disease: a case report." Journal of International Medical Research 49, no. 3 (2021): 030006052110016. http://dx.doi.org/10.1177/03000605211001633.

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A case of myelitis following Vogt-Koyanagi-Harada (VKH) disease is reported, in which diagnosis and treatment were delayed. A 43-year-old male patient diagnosed with VKH disease presented at the Spine Centre of Yeungnam University Hospital, Daegu, Republic of Korea, with motor weakness, sensory deficit in both lower extremities, and dysuria for the previous 3 months. VKH disease had been diagnosed 15 months previously, based on vision loss in both eyes and the presence of bilateral nontraumatic granulomatous iridocyclitis, exudates, and retinal oedema. The patient exhibited severe motor weakne

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Fujiwara, Keishi, Shinya Morita, Kimiko Hoshino, Atsushi Fukuda, Yuji Nakamaru, and Akihiro Homma. "Evaluation of Vestibular Functions in Patients with Vogt-Koyanagi-Harada Disease." Audiology and Neurotology 22, no. 3 (2017): 190–95. http://dx.doi.org/10.1159/000481426.

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Vogt-Koyanagi-Harada (VKH) disease is an idiopathic, multisystem autoimmune disorder characterized by bilateral, diffuse granulomatous uveitis associated with neurological, audiovestibular, and dermatological manifestations. The purpose of this study is to investigate vestibular functions in patients with VKH disease. A total of 43 patients with VKH disease in Hokkaido University Hospital were enrolled in this study. Subjective symptoms such as dizziness or vertigo and the results of various vestibular examinations including nystagmus testing, caloric testing, and vestibular-evoked myogenic po

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Le, Thanh-Thao Adriana, Sumu Simon, Jagjit Gilhotra, and Pravin Hissaria. "Vogt-Koyanagi-Harada syndrome presenting with bilateral optic disc swelling and leptomeningeal enhancement." BMJ Case Reports 12, no. 5 (2019): e229719. http://dx.doi.org/10.1136/bcr-2019-229719.

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Vogt-Koynagi-Harada (VKH) disease is a clinical syndrome with classical ocular and extraocular findings that is not uncommonly described in Asian, Middle-Eastern and South American populations. We describe a case of VKH in an elderly Polish-Australian distinguished by prominent bilateral disc swelling rather than uveitis and marked leptomeningeal enhancement on MRI which led to extensive investigation including brain biopsy. Both disc oedema and MRI abnormalities improved dramatically with systemic steroid therapy. VKH disease is an important differential to consider in older patients with an

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Mahendradas, Padmamalini, Ankush Kawali, Neha Bharti, et al. "The clinical spectrum of Vogt-Koyanagi-Harada syndrome: A single-center experience from South India." Internet Journal of Rheumatology and Clinical Immunology 1, S1 (2013): 01–08. http://dx.doi.org/10.15305/ijrci/v1is1/55.

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Aim To report the clinical features, investigations, management, and outcome in typical cases of Vogt-Koyanagi-Harada Syndrome (VKH) in a tertiary eye care center in South India. Materials and methods Retrospective interventional case series of VKH patients. Results Seventy-one eyes of 36 patients (age range 12-68 years) were included. Anatomical diagnoses were posterior uveitis (15 eyes) and pan uveitis (56 eyes). The classification of the cases with regard to VKH disease was as follows: six eyes were classified as complete, 41 eyes as incomplete, and 24 eyes as probable VKH disease. Commones

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Cherukuri, Navya, Somasheila I. Murthy, and Mudit Tyagi. "Effects of pregnancy on the clinical course and treatment outcomes of Vogt–Koyanagi–Harada disease." Indian Journal of Ophthalmology 73, Suppl 1 (2024): S158—S163. https://doi.org/10.4103/ijo.ijo_1251_24.

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Purpose: To describe the clinical course and treatment outcomes of Vogt–Koyanagi–Harada (VKH) disease during pregnancy. Methods: This retrospective study compares the clinical course and outcomes in pregnant and nonpregnant women with VKH. All VKH patients who were pregnant at presentation or on follow up and age-matched nonpregnant female controls during the study period (2013–2022) were included. Their best-corrected visual acuity (BCVA), clinical presentations, and treatment outcomes were analyzed. Results: Among the 532 female VKH patients, nine (1.7%) were included. Thirty nonpregnant pat

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Shimizu, Hiroyuki, Yoshihiko Usui, Masaki Asakage, et al. "Serum Metabolomic Profiling of Patients with Non-Infectious Uveitis." Journal of Clinical Medicine 9, no. 12 (2020): 3955. http://dx.doi.org/10.3390/jcm9123955.

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The activities of various metabolic pathways can influence the pathogeneses of autoimmune diseases, and intrinsic metabolites can potentially be used to diagnose diseases. However, the metabolomic analysis of patients with uveitis has not yet been conducted. Here, we profiled the serum metabolomes of patients with three major forms of uveitis (Behҫet’s disease (BD), sarcoidosis, and Vogt-Koyanagi-Harada disease (VKH)) to identify potential biomarkers. This study included 19 BD, 20 sarcoidosis, and 15 VKH patients alongside 16 healthy control subjects. The metabolite concentrations in their ser

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Accorinti, Massimo, Maria Carmela Saturno, Ludovico Iannetti, Priscilla Manni, Davide Mastromarino, and Maria Pia Pirraglia. "Treatment and Prognosis of Vogt–Koyanagi–Harada Disease: Real-Life Experience in Long-Term Follow-Up." Journal of Clinical Medicine 11, no. 13 (2022): 3632. http://dx.doi.org/10.3390/jcm11133632.

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Background: Vogt–Koyanagi–Harada (VKH) disease is a form of uveitis that is rare in Western countries. The aim of this study was to report on the long-term real-life treatment and prognosis of VKH in Italy. Methods: The clinical features, complications, and final visual acuity were retrospectively evaluated in 38 patients with VKH (mean follow-up: 120 months) globally, according to oral or intravenous corticosteroid treatment at onset and subsequent immunosuppressive therapy. Results: The mean final visual acuity was 0.13 ± 0.4 logMAR, which was a significant increase from the baseline (p <

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Verma, Saurabh, Himani Thakur, Shorya Vardhan Azad, and Vinod Kumar. "Delayed-onset unilateral Vogt-Koyanagi-Harada syndrome: a multimodal imaging appraisal." BMJ Case Reports 14, no. 2 (2021): e238623. http://dx.doi.org/10.1136/bcr-2020-238623.

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A 38-year-old woman who had previously been diagnosed and treated for unilateral Vogt-Koyanagi-Harada syndrome (VKH) and had undergone multiple intravitreal bevacizumab injections to manage inflammatory choroidal neovascularisation in her right eye, presented 2 years later with visual complains in left eye. Clinical examination, fluorescein angiography, indocyanine green angiography (ICGA) and enhanced depth imaging optical coherence tomography (EDI-OCT) assisted evaluation confirmed active inflammation of left eye along with absence of any inflammation in the right eye. Unilateral active infl

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De Domingo, Begoña, Miguel López, Maria Lopez-Valladares, Esperanza Ortegon-Aguilar, Bernardo Sopeña-Perez-Argüelles, and Francisco Gonzalez. "Vogt-Koyanagi-Harada Disease Exacerbation Associated with COVID-19 Vaccine." Cells 11, no. 6 (2022): 1012. http://dx.doi.org/10.3390/cells11061012.

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We describe a case of Vogt-Koyanagi-Harada (VKH) disease exacerbation after COVID-19 vaccination. A 46-year-old woman presented with a bilateral granulomatous uveitis 2 days after the first dose of COVID-19 mRNA vaccine (Comirnaty, Pfizer-BioNTech), and was diagnosed with a complete Vogt-Koyanagi-Harada (VKH) disease 4 days after receiving the second dose of the vaccine. Three weeks before the first dose, she had been consulted for blurred vision and mild headaches. The case resolved with high dose intravenous corticosteroids, followed by oral prednisone. The close temporal relationship betwee

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Hu, Youjin, Yixin Hu, Yuhua Xiao, et al. "Genetic landscape and autoimmunity of monocytes in developing Vogt–Koyanagi–Harada disease." Proceedings of the National Academy of Sciences 117, no. 41 (2020): 25712–21. http://dx.doi.org/10.1073/pnas.2002476117.

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Vogt–Koyanagi–Harada (VKH) disease is a systemic autoimmune disorder affecting multiple organs, including eyes, skin, and central nervous system. It is known that monocytes significantly contribute to the development of autoimmune disease. However, the subset heterogeneity with unique functions and signatures in human circulating monocytes and the identity of disease-specific monocytic populations remain largely unknown. Here, we employed an advanced single-cell RNA sequencing technology to systematically analyze 11,259 human circulating monocytes and genetically defined their subpopulations.

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Abdullayev N., Maus V., Mammadov C., Quliyeva Q., Ismayilova K., and Aliyev R.R. "Vogt-Koyanagi-Harada meninqoensefalitinin spontan remissiyası." NATIONAL JOURNAL OF NEUROLOGY, no. 18 (January 22, 2021): 74–77. http://dx.doi.org/10.28942/nnj.v2i18.309.

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Təqdim edilmiş klinik hadisədə VogtKoyanagiHarada (VKH) sindromu və gövdənin birincili bədxassəli melanoması ilə, və şişin ümumi proqressivləşməsi ilə təzahür edən, nevroloji simptomları olmayan, MRT müayinədə yeni kontrast qəbul edən kəllədaxili ocaqları olan 65 yaşlı xəstə təsvir edilir. Sistem melanoma xəstəliyi fonunda, VKH kəllədaxili təzahürü kimi, beyin zədələnmələrinin düzgün radioloji interpretasiyası xəstənin, beyinin lüzumsuz bütövlükdə radioterapiyadan qorunması üçün mütləq olmuşdur.

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Moya Ayre, Eugenio Franklin, and Iván Bermúdez Maldonado. "Adalimumab como alternativa terapéutica en el síndrome de Vogt Koyanagi Harada refractario al infliximab: reporte de caso." Anales de la Facultad de Medicina 77, no. 1 (2016): 55. http://dx.doi.org/10.15381/anales.v77i1.11554.

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El síndrome de Vogt Koyanagi Harada (VKH) consiste en una panuveitis bilateral que forma parte de los síndromes uveomeníngeos. El tratamiento en estadio crónico es difícil por presentar pobre respuesta a la inmunomodulación, por lo que se recurre a opciones terapéuticas como agentes biológicos tipo anti-TNF alfa. Se describe el caso de una paciente con VKH severo y resistencia al infliximab, quien mostró respuesta al adalimumab. El adalimumab es un anticuerpo monoclonal humanizado efectivo en casos de resistencia al infliximab en pacientes con síndrome de VKH crónico persistente. El caso es de

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Yan, Weiming, Yunpeng Wang, Xiangrong Zheng, et al. "Acute lymphocytic leukemia with initial manifestation of serous retinal detachment and choroidal thickening: case report and literature review." Journal of International Medical Research 49, no. 3 (2021): 030006052096437. http://dx.doi.org/10.1177/0300060520964373.

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This report describes a patient who had acute lymphocytic leukemia with exudative retinal detachment (RD), which mimicked Vogt–Koyanagi–Harada disease (VKH). A 61-year-old woman presented with painless loss of vision in the left eye. Fundus examination revealed RD in her left eye. B-scan ultrasonography confirmed localized RD and choroidal thickening. Fundus fluorescein angiography revealed stippled pinpoint hyperfluorescence in the upper macula. One week later, reduced visual acuity was noted in the right eye. B-scan ultrasonography and optical coherence tomography revealed serous RD in both

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ABU EL ASRAR, A. "Behçet disease, sarcoidosis, VKH." Acta Ophthalmologica 89, s248 (2011): 0. http://dx.doi.org/10.1111/j.1755-3768.2011.1345.x.

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ABU EL ASRAR, A. "Behçet disease, sarcoidosis, VKH." Acta Ophthalmologica 90 (August 6, 2012): 0. http://dx.doi.org/10.1111/j.1755-3768.2012.1613.x.

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KHAIRALLAH, M., and R. KAHLOUN. "Behçet disease, VKH, sarcoidosis." Acta Ophthalmologica 91 (August 2013): 0. http://dx.doi.org/10.1111/j.1755-3768.2013.1653.x.

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BOUCHENAKI, N., and CP HERBORT. "ICGA features in VKH." Acta Ophthalmologica 91 (August 2013): 0. http://dx.doi.org/10.1111/j.1755-3768.2013.2252.x.

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KHAIRALLAH, M., R. KAHLOUN, and S. BEN YAHIA. "Behçet’s disease, VKH, sarcoidosis." Acta Ophthalmologica 92 (August 20, 2014): 0. http://dx.doi.org/10.1111/j.1755-3768.2014.1743.x.

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Khairallah, M., R. Kahloun, and I. Ksiaa. "Behçet's disease, VKH, sarcoidosis." Acta Ophthalmologica 93 (September 23, 2015): n/a. http://dx.doi.org/10.1111/j.1755-3768.2015.0084.

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Yamashita, Yui, Yuki Hashimoto, Kenichi Namba, Kazuomi Mizuuchi, and Susumu Ishida. "Optic Nerve Head Microcirculation in Eyes with Vogt-Koyanagi-Harada Disease Accompanied by Anterior Ischemic Optic Neuropathy." Case Reports in Ophthalmology 12, no. 3 (2021): 899–908. http://dx.doi.org/10.1159/000520036.

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Anterior ischemic optic neuropathy (AION) is infrequently complicated with Vogt-Koyanagi-Harada (VKH) disease. We quantitatively examined sequential changes in the morphology and circulation hemodynamics, using a C-scan of optical coherence tomography (OCT) and laser speckle flowgraphy (LSFG) in a patient with VKH disease accompanied by AION. A 65-year-old female complained of blurred vision in both of her eyes. The patient presented with optic disc swelling and remarkable choroidal thickening detected by OCT bilaterally. The diagnosis of VKH disease was established based on the presence of pl

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Ye, Xiaoyuan, Haiping Zhang, Peng Xiao, et al. "Microvasculature Features of Vogt-Koyanagi-Harada Disease Revealed by Widefield Swept-Source Optical Coherence Tomography Angiography." Frontiers in Medicine 8 (October 14, 2021). http://dx.doi.org/10.3389/fmed.2021.719593.

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Background: Vogt-Koyanagi-Harada (VKH) disease is a multisystem autoimmune disorder which could induce bilateral panuveitis involving the posterior pole and peripheral fundus. Optical coherence tomography angiography (OCTA) provides several advantages over traditional fluorescence angiography for revealing pathological abnormalities of the retinal vasculature. Until recently, however, the OCTA field of view (FOV) was limited to 6 × 6 mm2 scans.Purpose: This study examined retinal vasculature and choriocapillaris abnormalities across multiple regions of the retina (15 × 9 mm2 wide field, macula

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Chang, Rui, Ying Zhu, Jing Xu, et al. "Identification of Urine Metabolic Biomarkers for Vogt-Koyanagi-Harada Disease." Frontiers in Cell and Developmental Biology 9 (February 25, 2021). http://dx.doi.org/10.3389/fcell.2021.637489.

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The diagnosis of Vogt-Koyanagi-Harada (VKH) disease is mainly based on a complex clinical manifestation while it lacks objective laboratory biomarkers. To explore the potential molecular biomarkers for diagnosis and disease activity in VKH, we performed an untargeted urine metabolomics analysis by ultra-high-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF/MS). Through univariate and multivariate statistical analysis, we found 9 differential metabolites when comparing VKH patients with healthy controls, and 26 differential metabolites wer

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"VKH." Das Juristische Büro 69, no. 10 (2018): 543–45. http://dx.doi.org/10.1515/jurbuero-2018-691017.

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Xiao, Peng, Ke Ma, Xiaoyuan Ye, et al. "Classification of Vogt-Koyanagi-Harada disease using feature selection and classification based on wide-field swept-source optical coherence tomography angiography." Frontiers in Bioengineering and Biotechnology 11 (May 2, 2023). http://dx.doi.org/10.3389/fbioe.2023.1086347.

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Background: Vogt-Koyanagi-Harada (VKH) disease is a common and easily blinded uveitis entity, with choroid being the main involved site. Classification of VKH disease and its different stages is crucial because they differ in clinical manifestations and therapeutic interventions. Wide-field swept-source optical coherence tomography angiography (WSS-OCTA) provides the advantages of non-invasiveness, large-field-of-view, high resolution, and ease of measuring and calculating choroid, offering the potential feasibility of simplified VKH classification assessment based on WSS-OCTA.Methods: 15 heal

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Jatwani, Karan, Venkatesh Kolli, Ali Raza Khaki, Atulya Aman Khosla, and Mayur Sarangdhar. "Unmasking a rare complication: Immune checkpoint inhibitors (ICIs) and Vogt-Koyanagi-Harada (VKH) syndrome." Journal of Clinical Oncology 43, no. 16_suppl (2025). https://doi.org/10.1200/jco.2025.43.16_suppl.e14667.

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e14667 Background: ICIs have changed the paradigm of cancer treatment, but their immune-modulating effects can lead to severe immune-related adverse events (irAEs). VKH syndrome, a rare autoimmune disorder affecting pigmented tissues specifically uvea, skin, inner ear and meninges has been reported as case reports with ICIs, although real word data to elaborate on this association is limited. We aimed to assess the pharmacovigilance (PV), reporting rate, reaction outcomes of VKH syndrome using the FDA Adverse Event Reporting System (FAERS) database. Methods: We identified 309,038 ICI-treated p

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Li, He, Lei Zhu, Xiuxing Liu, et al. "Peripheral immune landscape and natural killer-like B cells in human Vogt-Koyanagi-Harada disease." Life Medicine, December 8, 2022. http://dx.doi.org/10.1093/lifemedi/lnac047.

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Abstract Vogt-Koyanagi-Harada (VKH) disease is a systemic autoimmune disorder threatening the eyesight. The pathogenic mechanisms and biomarkers reflecting disease severity and predicting treatment response require further exploration. Here, we performed a single-cell analysis of peripheral blood mononuclear cells (PBMC) obtained from eight patients with VKH disease and eight healthy controls to comprehensively delineate the changes in VKH disease. We showed a mixture of inflammation, effector, and exhausted states for PBMCs in VKH disease. Notably, our study implicated a newly identified B ce

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Takeuchi, Masaki, Akira Meguro, Jutaro Nakamura, et al. "HLA-DRB1*04:05 is involved in the development of Vogt–Koyanagi–Harada disease-like immune-related adverse events in patients receiving immune checkpoint inhibitors." Scientific Reports 13, no. 1 (2023). http://dx.doi.org/10.1038/s41598-023-40565-z.

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AbstractImmune checkpoint inhibitors (ICIs) activate anti-tumor activity by inhibiting immune checkpoint molecules that suppress inflammatory T-cell activity. However, ICIs can initiate excessive immune responses, thereby causing immune-related adverse events (irAEs). ICI-associated uveitis (ICIU) is an irAE that affects the eyes. Although Vogt–Koyanagi–Harada disease (VKH)-like uveitis is a common form of ICIU, it is unclear which factors determine the ICIU form. We retrospectively reviewed the medical records of nine ICIU cases treated with ICIs for malignancies. We also performed HLA typing

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Zhang, Chuhua, Yun Wang, Yun Chen, et al. "Acute phase clinical manifestations of patients with Vogt-Koyanagi-Harada disease in Southern China." BMC Ophthalmology 23, no. 1 (2023). http://dx.doi.org/10.1186/s12886-023-02952-y.

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Abstract Backgrounds To characterize the acute phase clinical manifestations and visual outcomes of the patients with Vogt-Koyanagi Harada (VKH) disease in southern China. Methods In total, 186 patients with acute-onset VKH disease were recruited. The demographic data, clinical signs, ophthalmic examinations, and visual outcomes were analyzed. Results Among the 186 VKH patients, 3 were diagnosed as complete VKH, 125 as incomplete VKH, and 58 as probable VKH. All patients visited the hospital within 3 months of onset and complained of decreased vision. For the extraocular manifestations, 121 pa

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Urzua, Cristhian A., Carl P. Herbort, Masaru Takeuchi, et al. "Vogt-Koyanagi-Harada disease: the step-by-step approach to a better understanding of clinicopathology, immunopathology, diagnosis, and management: a brief review." Journal of Ophthalmic Inflammation and Infection 12, no. 1 (2022). http://dx.doi.org/10.1186/s12348-022-00293-3.

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Abstract Background Appraisals of Vogt-Koyanagi-Harada disease (VKH) have become progressively more complete, since its first description in 1906. The availability of new investigational methods has improved our knowledge of the immunopathology, clinicopathology, diagnosis, and management of VKH disease. This review aimed to describe some of the steps that led to better characterization of VKH as a clinical entity. Methods We searched on PubMed for articles that described the history of VKH disease and analyzed the progress in disease appraisal with new investigational and imaging methods. In

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