Journal articles on the topic 'Volume-2 Issue-1 (Jan-Feb) 2025'

Background: Cardiac myxomas are benign cardiac neoplasms usually found solitarily located within a single cardiac chamber, most commonly in the left atrium. With no established cause, they are often thought to occur spontaneously with no particular genetic cause or external incitement. While it has been explored, there is no universally accepted correlation with myxoma formation following a cardiac ablation procedure. We propose the theory of an iatrogenic causation of cardiac myxoma formation, likely incited by the local tissue injury during the transseptal puncture of the interatrial wall. Case Summary: We present the case of a 62-year-old male with a medical history significant for Atrial Fibrillation for which he underwent a transseptal ablation procedure, during which a puncture is made through the interatrial septum. Transthoracic and transesophageal echocardiograms obtained prior to the procedure did not reveal any intracardiac masses or abnormalities. Two-years post-procedure, during an inpatient hospitalization for a suspected asthma exacerbation, a new transthoracic echocardiogram demonstrated a pedunculated mass within the left atrium. 1. Rubio Alvarez J, Martinez de Alegria A, Sierra Quiroga J, Adrio Nazar B, Rubio Taboada C, Martinez Comendador JM. Rapid growth of left atrial myxoma after radiofrequency ablation. Tex Heart Inst J. 2013;40(4):459-61. PMID: 24082379; PMCID: PMC3783123. 2. Wada et al. General Thoracic and Cardiovascular Surgery Cases https://doi.org/10.1186/s44215-024-00145-7 3. Santillo E, Migale M, Marini L, Fallavollita L, Massini C, Balestrini F. Left atrial myxoma development after radiofrequency ablation of an atrial flutter substrate. JC Cases. 2015;11:124-6. 4. Kahraman, D. Et. Al. Refractory anemia and myxoma after radiofrequency ablation: a case report. Cardiovasc Surg Int 2016;3(1):15-17 http://dx.doi.org/DOI: 10.5606/e-cvsi.2016.479 5. Islam, AKMM. Cardiac Myxomas: A narrative Review. World J Cardiol 2022 April 26; 14(4): 206-219. 10.4330/wjc.v14.14.206 6. Satomi, K. Editorial: Incidental tumor or ablation-promoted oncogenesis? Journal of Cardiology Cases. 12 (2015) 30-31. http://dx.doi.org/10.1016/j.jccase.2015.04.001 7. AlAhmadi HH, Alsafwani NS, Shawarby MA, Ahmed F. Cardiac Myxoma: Typical Presentation but Unusual Histology. Case Rep Med. 2021 May 4;2021:6611579. doi: 10.1155/2021/6611579. PMID: 34035819; PMCID: PMC8116158. 8. Lee VH, Connolly HM, Brown RD. Central Nervous System Manifestations of Cardiac Myxoma. Arch Neurol.2007;64(8):1115–1120. doi:10.1001/archneur.64.8.1115 9. Okongwu CC, Olaofe OO. Cardiac myxoma: a comprehensive review. J Cardiothorac Surg. 2025 Mar 13;20(1):151. doi: 10.1186/s13019-024-03333-2. PMID: 40082903; PMCID: PMC11905437. 10. El Sabbagh, A, Al-Hijji, M, Thaden, J. et al. Cardiac Myxoma: The Great Mimicker. J Am Coll Cardiol Img. 2017 Feb, 10 (2) 203–206. https://doi.org/10.1016/j.jcmg.2016.06.018 11. I.M. Keeling, P. Oberwalder, M. Anelli-Monti, H. Schuchlenz, U. Demel, G.P. Tilz, P. Rehak, B. Rigler, Cardiac myxomas: 24 years of experience in 49 patients, European Journal of Cardio-Thoracic Surgery, Volume 22, Issue 6, December 2002, Pages 971–977, https://doi.org/10.1016/S1010-7940(02)00592-4 12. Ngow HA, Khairina WM. Atrial myxoma: histological confirmation. Heart Asia. 2011 Jan 1;3(1):43-4. doi: 10.1136/ha.2010.003046. PMID: 27325987; PMCID: PMC4898555. 13. Hamdan, M., Alam, B. & Kossaify, A. A polo ball in the right atrium, importance of echocardiographic characteristics of intracardiac myxomas: a case report. J Med Case Reports 17, 403 (2023). https://doi.org/10.1186/s13256-023-04130-6. 14. Wang JG, Li YJ, Liu H, Li NN, Zhao J, Xing XM. Clinicopathologic analysis of cardiac myxomas: Seven years experience with 61 patients. J Thorac Dis 2012;4 (3):272-283. DOI: 10.3978/j.issn.2072-1439.2012.05.07. 15. Zahra, K, Salma, S, Ali, T. et al. Giant Right Atrial Myxoma: Multimodality Imaging and Management. J Am Coll Cardiol Case Rep. 2025 Jan, 30 (2) https://doi.org/10.1016/j.jaccas.2024.102772. 16. Cotrim, N, Veiga, A, Castilho, B. et al. Giant Cardiac Myxoma as a Cause of Stroke. J Am Coll Cardiol Case Rep. 2024 Dec, 29 (24). https://doi.org/10.1016/j.jaccas.2024.102866. 17. Paraskevaidis IA, Michalakeas CA, Papadopoulos CH, AnastasiouNana M. Cardiac tumors. ISRN Oncol. 2011;2011:208929. doi: 10.5402/2011/208929. Epub 2011 May 26. PMID: 22091416; PMCID: PMC3195386. 18. Nektaria M, Theologou S, Christos C, George S, Rokeia E, Dimitrios S, Ioanna P. Cardiac myxomas: A single-center case series of 145 patients over a 32-year period study. Ann Card Anaesth. 2023 Jan-Mar;26(1):17-22. doi: 10.4103/aca.aca_290_20. PMID: 36722583; PMCID: PMC9997480. 19. Sido V, Volkwein A, Hartrumpf M, Braun C, Kühnel RU, Ostovar R, Schröter F, Chopsonidou S, Albes JM. Gender-Related Outcomes after Surgical Resection and Level of Satisfaction in Patients with Left Atrial Tumors. J Clin Med. 2023 Mar 6;12(5):2075. doi: 10.3390/jcm12052075. PMID: 36902863; PMCID: PMC10003994. 20. Lima NA, Byers-Spencer K, Cwikla K, Huffman C, Diaz M, Melgar TA, Helmstetter N. Benign Cardiac Neoplasms in the United States: A Thirteen-Year Review. Cardiology. 2021;146(6):748-753. doi: 10.1159/000519290. Epub 2021 Sep 1. PMID: 34469887; PMCID: PMC8743935. 21. Saleh Y, Hammad B, Almaghraby A, Abdelkarim O, Seleem M, Abdelnaby M, Shehata H, Hammad M, Ramadan B, Elshafei M, Elsharkawy E, Abdel-Hay MA. Carney Complex: A Rare Case of Multicentric Cardiac Myxoma Associated with Endocrinopathy. Case Rep Cardiol. 2018 Jul 2;2018:2959041. doi: 10.1155/2018/2959041. PMID: 30065853; PMCID: PMC6051319. 22. Amano J, Kono T, Wada Y, Zhang T, Koide N, Fujimori M, Ito K. Cardiac myxoma: its origin and tumor characteristics. Ann Thorac Cardiovasc Surg. 2003 Aug;9(4):215-21. PMID: 13129418. 23. Orlandi A, Ciucci A, Ferlosio A et al (2006) Cardiac myxoma cells exhibit embryonic endocardial stem cell features. J Pathol 209(2):231-239. https://doi.org/10.1002/path.1959. 24. Sakamoto H, Sakamaki T, Sumino H, Sawada Y, Sato H, Sato M, Fujita K, Kanda T, Tamura J, Kurabayashi M. Production of endothelin-1 and big endothelin-1 by human cardiac myxoma cells- -implications of the origin of myxomas--. Circ J. 2004 Dec;68(12):1230-2. doi: 10.1253/circj.68.1230. PMID: 15564714. 25. Singhal P, Luk A, Rao V, Butany J (2014) Molecular basis of cardiac myxomas. Int J Mol Sci 15(1):1315–1337. https://doi.org/10.3390/ijms15011315. 26. Sughimoto K., Shiikawa A., Ohkado A., Nanaumi M. Multiple cardiac myxomas with pulmonary artery obstruction and acute right heart failure. Jpn. J. Thorac. Cardiovasc. Surg. 2004;52:530–533. doi: 10.1007/s11748-004-0005-3. 27. Mendyka D, Płonek T, Jędrasek T, Korman A, Złotowska A, Jędrasek A, Skalik R, Kustrzycki W. The Therapeutic Potential of Different Surgical Approaches in the Management of Cardiac Myxoma: A Systematic Review. J Clin Med. 2024 Dec 28;14(1):121. doi: 10.3390/jcm14010121. PMID: 39797207; PMCID: PMC11722112. 28. Changing management of cardiac myxoma based on a series of 40 cases with long-term follow-up Selkane, Chekir et al. The Annals of Thoracic Surgery, Volume 76, Issue 6, 1935 – 1938. 29. Argueta EE, Ratheal K, Prieto S, Paone R, Jenkins LA, Oyenuga O. Recurrent atrial myxoma, right atriotomy, and sinus node dysfunction: a case of interdisciplinary care. The Southwest Respiratory and Critical Care Chronicles 2018;6(23):42–46. 30. Scalise M, Torella M, Marino F, Ravo M, Giurato G, Vicinanza C, Cianflone E, Mancuso T, Aquila I, Salerno L, Nassa G, Agosti V, De Angelis A, Urbanek K, Berrino L, Veltri P, Paolino D, Mastroroberto P, De Feo M, Viglietto G, Weisz A, Nadal-Ginard B, Ellison-Hughes GM, Torella D. Atrial myxomas arise from multipotent cardiac stem cells. Eur Heart J. 2020 Dec 1;41(45):4332-4345. doi: 10.1093/eurheartj/ehaa156. PMID: 32330934; PMCID: PMC7735815.

<strong>FEB-2024 | VOLUME-2 | ISSUE-2 </strong> <strong>https://entechonline.com/feb-2024-volume-2-issue-1/</strong> The&nbsp;<strong>Entech February 2024</strong> Issue of<strong> ENTECH Magazine</strong> presents the cover story, <strong>&ldquo;A New Design for a Solar Dryer: Part I Introduction&rdquo;</strong>, for Sustainable Agriculture by <strong>Dr. S. D. Suryawanshi</strong> based on his patented design. <strong>&nbsp;</strong> An original article <strong>&ldquo;Revolutionizing medication management: The Smart Pill Dispenser&rdquo;</strong> by <strong>Kedareshwar Goranale.</strong> A Nature Focus article<strong> &ldquo;The Dye Industry and Environmental Impact: Part II the Toxic Truth&rdquo;</strong> by <strong>Nagraj</strong>. <strong>&nbsp;</strong>A review article <strong>&ldquo;Mechanical Engineering Explained: Part I Introduction&rdquo;</strong> by <strong>Atil Arora and Ayush Gupta</strong>.&nbsp; TECH Focus article on<strong> &ldquo;All About AI: Part 1&rdquo;</strong> by <strong>Kautilya Katariya,</strong> Youngest Computer Programmer.&nbsp; A commentary <strong>&ldquo;How Internet Works: An Essential Guide for Your Safety&rdquo;</strong> by<strong> Deven Nandapurkar.&nbsp;</strong><strong>&nbsp;</strong> A commentary <strong>&ldquo;Nanotechnology Is Changing the Health Care and Medicine Industries: The Power of Small&rdquo;</strong> by <strong>Dr. Sunita Singh.</strong><strong>&nbsp;</strong> An original article <strong>&ldquo;How it is Made: The Lead Acid Battery (Part 5) &ndash; Paste Preparation&rdquo;</strong> by SOVEMA Group.<strong>&nbsp;</strong> <strong>Answers to the math puzzle from the previous issue</strong> by <strong>Jaya Ghosh.</strong> &nbsp; Science and Technology NEWS curated for you. We are asking for contributions to help us continue. We need articles, advertisements, news stories, and other forms of collaboration. <strong>The Entech February 2024 Issue</strong> also highlights the latest advancements in nuclear fusion technology in the editorial. Please share this link with a message on your social media handles, WhatsApp groups, etc. <strong>https://entechonline.com/feb-2024-volume-2-issue-1/</strong> #CareerGuidance #JobAdvice #CareerAdvice #LinkedInTips #JobSearchTips #CareerStrategy #CareerSuccess #PassionToProfession

<strong>JAN-2024 | VOLUME-2 | ISSUE-1</strong> The&nbsp;<strong>JANUARY 2024 issue of ENTECH</strong> Magazine presents the cover story &ldquo;<strong>Flying Start of MAKE IN INDIA</strong>&rdquo; &ndash; an interview with&nbsp;<strong>Meet Desai</strong>, one of the youngest entrepreneurs in the aerospace domain; feature story on &ldquo;<strong>Ongoing Exploration in Gravitational Space Biology</strong>&rdquo; by&nbsp;<strong>Pandit Vidyasgar</strong>&nbsp;and&nbsp;<strong>Jyotsana Dixit</strong>; Nature Focus article on &ldquo;<strong>The Dye Industry and Environmental Impacts</strong>&rdquo; by&nbsp;<strong>Nagraj</strong>; LIFE Focus article on &ldquo;<strong>Cooling without Electricity: Harnessing the Pot-in-Pot Refrigerator Principle</strong>&rdquo; by&nbsp;<strong>Atil Arora and Sanjeev Jha</strong>; TECH Focus article on &ldquo;<strong>Computational Complexity</strong>&rdquo; by&nbsp;<strong>Kautilya Katariya</strong>, Youngest Computer Programmer, Career Focus article on &ldquo;<strong>HOW TO JOIN FLYING BRANCH OF INDIAN AIR FORCE</strong>&rdquo; by Sqn Ldr Sachin Bhatnagar (retd), a new &ldquo;<strong>Math Puzzle</strong>&rdquo; to keep your brain fresh and active by renowned math writer&nbsp;<strong>Jaya Ghosh</strong>, answers to the math puzzle from the previous issue, &ldquo;<strong>How it is Made: The Lead Acid Battery (Part 4) &ndash; Oxide Production</strong>&rdquo; by&nbsp;<strong>SOVEMA Group</strong>, a call for contributions to keep us alive, a call for articles, a call for advertisements, a call for news articles, and a call for other collaborative opportunities. The issue also highlights the need for a sustainable lifestyle in the editorial. Please share this link with a message on your social media handles, WhatsApp groups, etc. #CareerGuidance #JobAdvice #CareerAdvice #LinkedInTips #JobSearchTips #CareerStrategy #CareerSuccess #PassionToProfession <strong>https://entechonline.com/jan-2024-volume-2-issue/</strong> ENTECH magazine is for teenagers, especially in the age group of 13&ndash;17, who are fascinated by Science Technology Engineering and Mathematics, STEM. ENTECH magazine will help teenagers explore areas that spark their interest and discover their passion.&nbsp;

Coronary artery aneurysms (CAAs) are relatively rare defects that range significantly in clinical presentation, most often discovered in adults with concomitant coronary artery disease. There remains no general consensus on the optimal management of CAAs. A vast majority of cases reported in literature are managed operatively or with percutaneous stenting. We however demonstrate a case of a CAA discovered upon angiography for a STEMI managed entirely with intracoronary thrombolytics and intravenous heparin, followed by a repeat coronary angiography that confirmed re-opening of the occluded vessel now with distal coronary blood flow. 1. Matta AG, Yaacoub N, Nader V, Moussallem N, Carrie D, Roncalli J. Coronary artery aneurysm: A review. World J Cardiol. 2021 Sep 26;13(9):446-455. doi: 10.4330/wjc.v13.i9.446. PMID: 34621489; PMCID: PMC8462041. 1. Kawsara, A, Núñez Gil, I, Alqahtani, F. et al. Management of Coronary Artery Aneurysms. J Am Coll Cardiol Intv. 2018 Jul, 11(13) 1211–1223. https://doi.org/10.1016/j. jcin.2018.02.041 2. Kacila M, Matteucci ML, Bevilacqua S, Granov N, Glauber M. Treatment of left anterior descending artery aneurysm. Bosn J Basic Med Sci. 2006 Nov;6(4):22-4. doi: 10.17305/ bjbms.2006.3113. PMID: 17177643; PMCID: PMC5807962. 3. Sheikh AS, Hailan A, Kinnaird T, Choudhury A, Smith D. Coronary Artery Aneurysm: Evaluation, Prognosis, and Proposed Treatment Strategies. Heart Views. 2019 Jul-Sep;20(3):101-108. doi: 10.4103/HEARTVIEWS. HEARTVIEWS_1_19. PMID: 31620255; PMCID: PMC6791093. 4. Swaye PS, Fisher LD, Litwin P, Vignola PA, Judkins MP, Kemp HG, et al. Aneurysmal coronary artery disease. Circulation. 1983;67:134–8. doi: 10.1161/01.cir.67.1.134. 5. Sushil Kumar Singh, Tushar Goyal, Rishi Sethi, Sharad Chandra, Vijayant Devenraj, Nitin Kumar Rajput, Dinesh Kaushal, Vivek Tewarson, Santosh Gupta, Sarvesh Kumar, Surgical treatment for coronary artery aneurysm: a single-centre experience, Interactive CardioVascular and Thoracic Surgery, Volume 17, Issue 4, October 2013, Pages 632-636, https://doi. org/10.1093/icvts/ivt282 6. Morita H, Ozawa H, Yamazaki S, Yamauchi Y, Tsuji M, Katsumata T, Ishizaka N. A case of giant coronary artery aneurysm with fistulous connection to the pulmonary artery: a case report and review of the literature. Intern Med. 2012;51(11):1361- 6. doi: 10.2169/internalmedicine.51.7134. Epub 2012 Jun 1. PMID: 22687842. 7. Barioli A, Visco E, Pellizzari N, Marzot F, Lanzellotti D, Favero L, Cernetti C. Diagnostic workup and treatment options for aneurysmal coronary artery disease. Vessel Plus. 2024;8:13. http://dx.doi.org/10.20517/2574-1209.2023.68 8. Abou Sherif S, Ozden Tok O, Tas ̧köylü Ö, Goktekin O and Kilic ID (2017) Coronary Artery Aneurysms: A Review of the Epidemiology, Pathophysiology, Diagnosis, and Treatment. Front. Cardiovasc. Med. 4:24. doi: 10.3389/fcvm.2017.00024 9. Chauhan et al.: An unruptured, thrombosed 10 cm right coronary artery aneurysm mimicking a pericardial cyst. Journal of Cardiothoracic Surgery 2013 8:2. 10. Sannino, M.; Nicolai, M.; Infusino, F.; Giulio, L.; Usai, T.L.; Biscotti, G.; Azzarri, A.; De Angelis D’Ossat, M.; Calcagno, S.; Calcagno, S. Coronary Artery Aneurysms: A Clinical Case Report and Literature Review Supporting Therapeutic Choices. J. Clin. Med. 2024, 13, 5348. https://doi.org/10.3390/jcm13185348 11. Pham, V.; Hemptinne, Q.; Grinda, J.; Duboc D.; Varenne, O.; Picard, F. Giant coronary aneurysms, from diagnosis to treatment: A literature review. Archives of Cardiovascular Diseases. 2020, January, 113(1), 59-69. https://doi.org/10.1016/j. acvd.2019.10.008 12. Khouzam, M.S., Khouzam, N. Giant coronary artery aneurysms involving more than one coronary artery: case report. J Cardiothorac Surg 16, 177 (2021). https://doi.org/10.1186/ s13019-021-01560-5. 13. Ramirez, F.D., et. Al. Natural History and Management of Aortocoronary Saphenous Vein Graft Aneurysms. A Systematic Review of Published Cases. American Heart Association. 2012 Oct, (126)18, 1524-4539. 14. Nichols, L., Lagana, S., Parwani, A. Coronary Artery Aneurysm. A Review and Hypothesis Regarding Etiology. Arch Pathol Lab Med (2008) 132 (5): 823–828. https://doi.org/10.5858/2008- 132-823-CAAARA. 15. Bajaj, S. Et Al. Covered-Stent Treatment of Coronary Aneurysm after Drug-Eluting Stent Placement, Case Report and Literature ReviewTex Heart Inst 2010;37(4):449-54). 16. Aoki J, Kirtane A, Leon MB, Dangas G. Coronary artery aneurysms after drug-eluting stent implantation. JACC Cardiovasc Interv. 2008 Feb;1(1):14-21. doi: 10.1016/j. jcin.2007.10.004. PMID: 19393139. 17. Befeler B, Aranda MJ, Embi A, Mullin FL, El-Sherif N, Lazzara R. Coronary artery aneurysms: study of the etiology, clinical course and effect on left ventricular function and prognosis. Am J Med. 1977;62:597-607. 18. Pasha, A.K., Jokerst, C.E., Janardhanan, R. Myocardial Infarction related to a Coronary Artery Aneurysm. The American Journal of Medicine. 2015, February (128)2. http://dx.doi. org/10.1016/j.amjmed.2014.10.017. 19. ElGuindy MS, ElGuindy AM. Aneurysmal coronary artery disease: An overview, Global Cardiology Science and Practice 2017:26. http://dx.doi.org/10.21542/gcsp.2017.26. 20. Khubber S, Chana R, Meenakshisundaram C, et al. Coronary artery aneurysms: outcomes following medical, pinterventional and surgical management. Open Heart 2021;8:e001440. doi:10.1136/openhrt-2020-001440. 21. Sugiyama, K., Matsuyama, K., Maruno, K. et al. A case of ruptured infective coronary artery aneurysm. surg case rep 3, 75 (2017). https://doi.org/10.1186/s40792-017-0347-6. 22. Johnson, P.T., Fishman, E.K. CT Angiography of Coronary Artery Aneurysms; Detection, definition, causes, and treatment. American Journal of Roentology. 2010, March (195)4. https:// doi.org/10.2214/AJR.09.3517. 23. Kacila M, Matteucci ML, Bevilacqua S, Granov N, Glauber M. Treatment of left anterior descending artery aneurysm. Bosn J Basic Med Sci. 2006 Nov;6(4):22-4. doi: 10.17305/ bjbms.2006.3113. PMID: 17177643; PMCID: PMC5807962. 24. Beyer, M., Shoap, S., Beyer, E. Massive Giant Coronary Aneurysm. Annals of Thoracic Surgery. 2024, March (2)1, 38-39. https:// doi.org/10.1016/j.atssr.2023.09.001. 25. Hannah, E.L., Et Al. Circulation: Cardiovascular Interventions. American Heart Association.2022,June(15)6. https://www.ahajournals.org/doi/suppl/10.1161/ CIRCINTERVENTIONS.121.011687. 26. Zhu Et. Al., Challenges and strategies in the management of coronary artery aneurysms. Hellenic Journal of Cardiology 62 (2021) 112-120. https://doi.org/10.1016/j.hjc.2020.09.004. 27. 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Intracoronary eptifibatide bolus administration during percutaneous coronary revascularization for acute coronary syndromes with evaluation of platelet glycoprotein IIb/IIIa receptor occupancy and platelet function: the Intracoronary Eptifibatide (ICE) Trial. Circulation. 2010 Feb 16;121(6):784- 91. doi: 10.1161/CIRCULATIONAHA.109.882746. 31. Kumar, V. Et. Al. Large intracoronary thrombus and its management during primary PCI. Indian Heart Journal. 72 (2020) 508-516. https://doi.org/10.1016/j.ihj.2020.11.009. 32. Gülec S, Aras O, Atmaca Y, Akyürek O, Hanson NQ, Sayin T, Tsai MY, Akar N, Oral D. Deletion polymorphism of the angiotensin I converting enzyme gene is a potent risk factor for coronary artery ectasia. Heart. 2003 Feb;89(2):213-4. doi: 10.1136/ heart.89.2.213. PMID: 12527685; PMCID: PMC1767548. 33. Zhu L, Cui Q, Liu Y, Liu Z, Zhang Y, Liu F, Wang J. Effects of a Secondary Prevention Combination Therapy with betaBlocker and Statin on Major Adverse Cardiovascular Events in Acute Coronary Syndrome Patients. Med Sci Monit. 2020 Aug 18;26:e925114. doi: 10.12659/MSM.925114. PMID: 32808600; PMCID: PMC7453752. 34. Gebbers JO. Atherosclerosis, cholesterol, nutrition, and statins- -a critical review. Ger Med Sci. 2007 Aug 16;5:Doc04. PMID: 19675712; PMCID: PMC2703237. 35. Hedblad B, Wikstrand J, Janzon L, Wedel H, Berglund G. Lowdose metoprolol CR/XL and fluvastatin slow progression of carotid intima-media thickness: Main results from the Beta-Blocker Cholesterol-Lowering Asymptomatic Plaque Study (BCAPS). Circulation. 2001 Apr 3;103(13):1721-6. doi: 10.1161/01.cir.103.13.1721. PMID: 11282901. 36. Hu M, Hu S, Gao X, Yang Y. Beta-Blocker Use after Discharge in Patients with Acute Myocardial Infarction in the Contemporary Reperfusion Era. Medicina (Kaunas). 2022 Aug 30;58(9):1177. doi: 10.3390/medicina58091177. 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Epub 2017 Sep 30. PMID: 29181042; PMCID: PMC5701588. 41. Demopoulos VP, Olympios CD, Fakiolas CN, Pissimissis EG, Economides NM, Adamopoulou E, Foussas SG, Cokkinos DV. The natural history of aneurysmal coronary artery disease. Heart. 1997 Aug;78(2):136-41. doi: 10.1136/hrt.78.2.136. PMID: 9326986; PMCID: PMC484892. 42. Thangathurai J, Kalashnikova M, Takahashi M, Shinbane JS. Coronary Artery Aneurysm in Kawasaki Disease: Coronary CT Angiography through the Lens of Pathophysiology and Differential Diagnosis. Radiol Cardiothorac Imaging. 2021 Oct 28;3(5):e200550. doi: 10.1148/ryct.2021200550. PMID: 34778780; PMCID: PMC8581589. 43. Van Stijn D, Korbee JM, Netea SA, de Winter VC, Zwinderman KAH, Kuipers IM, Kuijpers TW. Treatment and Coronary Artery Aneurysm Formation in Kawasaki Disease: A Per-Day Risk Analysis. J Pediatr. 2022 Apr;243:167-172.e1. doi: 10.1016/j. jpeds.2021.12.054. Epub 2021 Dec 27. PMID: 34968497. 44. Senzaki H. 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Nancy Y. Disasters Due to Garbage, Floods and Landslides [Internet]. 2021 [cited 2022 Feb 8]. Available from: https://tirto.id/bencana-hasil-sampah-gunung- until-longsor-sampah-gaB Z Wardhana AH. Black Soldier Fly (Hermetia illucens) as an Alternative Protein Source for Animal Feed. WARZOA. 2016;26(2):69–78. United Nations Goal 12 | Department of Economic and Social Affairs [Internet]. [cited 2022 Feb 12]. Available from: https://sdgs.un.org/goals/goal12 SIPSN. SIPSN - National Waste Management Information System [Internet]. 2021 [cited 2022 Jan 25]. Available from: https://sipsn.menlhk.go.id/sipsn / i?ková H, Newton GL, Lacy RC, Kozánek M. The use of fly larvae for organic waste treatment. Waste Manag. 2015 Jan 1:35:68–80. Rindhe SN, Chatli MK, Wagh RV, Kaur A, Mehta N, Kumar P, et al. Black Soldier Fly: A New Vista for Waste Management and Animal Feed. Int J Curr Microbiol Appl Sci. 2019 Jan 20;8(01):1329–42. Diener S, Studt Solano NM, Roa Gutiérrez F, Zurbrügg C, Tockner K. Biological treatment of municipal organic waste using black soldier fly larvae. Waste and Biomass Valorization [Internet]. 2011 Nov 18 [cited 2022 Jan 28];2(4):357–63. Available from: https://link.springer.com/article/10.1007/s12649-011-9079-1 Supriyatna A, Kurahman OT, Cahyanto T, Yuliawati A, Kulsum Y, Supriyatna A, et al. The Potency of Black Soldier Larvae (Hermetia illucens L.) as a Source of Protein for Livestock Feed. Bioscientific J Biol Biol Educ [Internet]. 2018 Aug 29 [cited 2022 Jan 28];10(2):448–54. Available from: https://journal.unnes.ac.id/nju/index.php/biosaintifika/article/view/14422 Liu T, Awasthi MK, Chen H, Duan Y, Awasthi SK, Zhang Z. Performance of black soldier fly larvae (Diptera: Stratiomyidae) for manure composting and production of cleaner compost. J Environment Manage. 2019 Dec 1:251:109593.

Folia Biologica celebrates 70 years of continuous publication of research papers. The first volume was published in Prague in 1954 on behalf of the Institute of Molecular Genetics of the Czechoslovak Academy of Sciences (since 1990 the Academy of Sciences of the Czech Republic) under the subtitle “International edition of the journal Czechoslovakian Biology”. Born in the dark days of the Cold War, Folia Biologica provided a thin but important link between the politically controlled science behind the Iron Curtain in the former Czechoslovakia and that of the free Western world. Initially, the journal focused on research papers in the fields of experimental medicine, immunology, virology, and experimental zoology. Since 1961 (Volume 7), Folia Biologica has been indexed in the Web of Science database. The first issue of Volume 7 was introduced by a review article by Peter Brian Medawar (1915–1987), winner of the 1960 Nobel Prize in Physiology or Medicine “for the discovery of acquired immunological tolerance”, which is reprinted in this anniversary issue [1].In the late 1960s, during the political relaxation that culminated in the Prague Spring, cooperation with free Western science intensified and enabled a lively scientific dialogue between Czechoslovak and foreign biological scientists, namely immunologists, molecular biologists, and virologists, as illustrated by a series of original research articles from Folia Biologica by Georg Davis Snell (1903–1996) and Jean Dausset (1916–2009), who were awarded the Nobel Prize in Physiology and Medicine in 1980 “for their discoveries concerning genetically determined structures on the cell surface that regulate immunological reactions”, which led to the discovery of the major histocompatibility system (MHC) [2–7]. Another powerful example is an article in Folia Biologica by François Jacob (1920–2013), who was awarded the Nobel Prize in 1965 for discoveries that helped elucidate the transcriptional control of enzyme levels [8].Despite the years of political repression during the “normalization” period following the invasion of the Warsaw Pact troops into Czechoslovakia in 1968, the scientists and editors of Folia Biologica from the Academy of Sciences were able to maintain vibrant contacts with the world’s leading scientists. In 1981, the journal changed its subtitle to “Journal of Cellular and Molecular Biology”. In 1983, Folia Biologica published the article by Renato Dulbecco (1914–2012), who was awarded the Nobel Prize in 1975 for “discoveries concerning the interaction between tumor viruses and the genetic material of the cell”[9].With further orientation towards human molecular medicine, the journal entered the era after the Velvet Revolution in 1989, which represented the desired end of political control over national science. The interest of Czechoslovak and Czech scientists in publishing in Folia Biologica began to decline at the end of the 1990s, when they had at their disposal the full range of scientific journals from all over the world. Since volume 63 (January 2006), Folia Biologica has been published by the First Faculty of Medicine, Charles University, Prague, in a fully open access model.With the new decade that begins with this issue, the journal has undergone a series of improvements, including the strengthening of the editorial board, the assignment of a DOI (Digital Object Identifier) number to each article, the improvement of the cover layout and graphics, the innovation of the website, and a more precise definition of the journal’s aim. Folia Biologica now publishes articles describing original research aimed at elucidating a wide range of issues in biomedicine, especially in oncology and human molecular genetics. In addition, the journal focuses on the cellular and molecular mechanisms of disease and provides studies on all organisms, cells and tissues that serve as biological and disease models, as well as clinical and translational research studies. Further improvements towards sustainable and rapid publication will be accomplished by introducing an online-only publication model planned for 2025.To celebrate the 70th anniversary of Folia Biologica, we begin the anniversary volume with the reprint of Sir Peter Brian Medawar’s review. To commemorate the continuing history of the journal, and to thank our predecessors and contributors, we present the title pages, table of contents, and editorial boards of Folia Biologica by decade, illustrating the changes in research focus, human knowledge, and the evolution of the journal.We would like to thank all authors, reviewers, editorial board members, editors and managing editors involved in the journal production in the past decades, namely Ivan Málek, Milan Hašek, Alena Langerová, Josef Říman, Jan Bubeník, Jan Svoboda, Emanual Nečas, Karel Smetana Jr. and Zdeněk Kostrouch, for their commitment and dedication to Folia Biologica.We wish our journal many more decades of scientifically interesting articles, publishing open-minded science by excellent authors for the pleasure of satisfied readers!

<strong>Abstract:</strong><strong> </strong>Equipping teachers to work with neurodiverse learners still deserves focus and has received none when preparing educators to teach at schools. While policies regarding education inclusivity attempt to highlight and address the issue of accessibility, there is still no formal methodology within teacher training courses that focus on how to aid educators in instructing neurodiverse learners. This paper aims to fill that gap by proposing a pedagogical framework of teacher preparedness which integrates universal design for learning (UDL), differentiated instruction, and cognitive psychology. The main goal of the research paper was to examine the existing documents and literature to determine the gaps in traditional forms of education and teacher training programs. This study proposes a new model of systematic education which employs the principles of competency-based education with its requirement of active participation, flexible forms, and the use of assistive devices for evaluation. This framework is designed to resolve the gap between theoretical knowledge and practical application, so that new teachers can develop and implement adaptive instruction and inclusive environments. This paper adds to the conversation on inclusive teacher education by providing a clear roadmap for incorporating neurodiversity-responsive teaching methods into teacher training programs. It advocates for curriculum changes that emphasize practical experience and evidence-based approaches, encouraging policymakers and educators to reconsider teacher preparation for a more equitable education system. Future studies should empirically test the suggested framework in various educational environments. <strong>&nbsp;</strong>

Abd-el-salam, E. M., Shawky, A. Y., &amp; El-nahas, T. (2013). The impact of corporate image and reputation on service quality, customer satisfaction, and customer loyalty : testing the mediating role. Case analysis in an international service company. 8(1), 130–153. Ahmed, Z., Rizwan, M., Ahmad, M., &amp; Haq, M. (2014). Effect of brand trust and customer satisfaction on brand loyalty in Bahawalpur. Journal of Sociological Research, 5(1), 306–326. https://doi.org/10.5296/jsr.v5i1.6568 Alwie, A. F. (2024). Analysis of Customer Satisfaction with Non-Subsidized Fuel at Pertamina SPBU in Pelalawan Regency–Riau Province. Journal of Ecohumanism, 3(3), 530–543.Ardhiansyah, N., Sri, M. S., &amp; Yunanto, A. (2019). Impact of Brand Trust on Customer Satisfaction and Customer Loyalty. International Conference on Rural Development and Entrepreneurship 2019: Enhancing Small Business and Rural Development Towards Industrial Revolution 4.0, 2(9), 288–293.Azizan, N. S., &amp; Yusr, M. M. (2019). The Influence of Customer Satisfaction, Brand Trust, and Brand Image Towards Customer Loyalty. International Journal of Entrepreneurship and Management Practices, 2(7), 93–108. https://doi.org/10.35631/ijemp.270010 Cuong, D. T., &amp; Khoi, B. H. (2019). The relationship between service quality, satisfaction, trust, and customer loyalty was studied in a study of convenience stores in Vietnam. Journal of Advanced Research in Dynamical and Control Systems, 11(1 Special Issue), 327–333.Damayanti, C., &amp; Wahyono. (2015). Pengaruh Kualitas Produk, Brand Image Terhadap Loyalitas Dengan Kepuasan Sebagai Variabel Intervening. Management Analysis Journal, 4(3), 236–251.Desiyanti, N. L., Sudja, I. N., &amp; Budi Martini, L. K. (2018). Effect of Service Quality on Customer Satisfaction, Customer Delight and Customer Loyalty (Study on LPD Desa Adat Sembung and LPD Desa Adat Seseh). 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The Impact of Market Orientation, Product Innovation, and Competitive Advantage on the Marketing Performance of Culinary Enterprises: Empirical Study in Kampar Regency, Indonesia. Golden Ratio of Marketing and Applied Psychology of Business, 5(1), 79-94.Kotler, P. (2019). Manajemen Pemasaran. Erlangga.Kotler, P., &amp; Amstrong, G. (2016). Manajemen Pemasaran. PT. Indeks Kelompok Gramedia.Kotler, P., &amp; Keller, K. L. (2016a). Manajemen Pemasaran (Bob Sabran (ed.); Ed 13). Erlangga.Kotler, P., &amp; Keller, K. L. (2016b). Marketing Management Global Edition (Vol. 15E). https://doi.org/10.1080/08911760903022556 Kuswandarini, K. I., &amp; Annisa, A. A. (2021). Analisis pengaruh kualitas layanan, corporate image, dan customer relationship management terhadap loyalitas nasabah dengan kepuasan nasabah sebagai variabel intervening. Journal of Management and Digital Business, 1(1), 37–51. https://doi.org/10.53088/jmdb.v1i1.46 Lupiyoadi, &amp; Hamdani. (2015). Manajemen Pemasaran Jasa. 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In first article (Heal Talk // Nov-Dec 2023 // Vol-16 // No-2 // Issue-92, Pg No-14-15) of this medico-legal column, readers have seen in brief, general idea about introduction of medico-legal issues. In second article (Heal Talk // Jan-Feb 2024 // Vol-16 // No-3 // Issue-93, Pg No-16-18) of this medico-legal column, we have seen concept and importance of informed consent. Thus the readers understood the subject law and health and also law and medicine. The earlier articles also touched to the various terminologies of laws, rules, regulations, guidelines which governs medico-legal issues in Clinical Dental Practice. Along with the above terminologies it is must to know and understand for each dental practitioner about the concept of Medical Negligence resulting in to doctor's liability in Dental profession.

<strong>ABSTRACT</strong> Ethno-Veterinary Medicine (EVM) or Veterinary Anthropology refers to holistic and interdisciplinary study of traditional knowledge, skills, methods, practices and folk beliefs of the people about the health care, healthful husbandry and production of livestock (Yadav, 2014, Mc Corkle, 1986, 1996). This study aims to document information about ethno-botanical information and its traditional use by the local inhabitant for the treatment of livestock in different villages of Nainital district, Uttarakhand. Traditional use of plant and plant resources has a long history in Uttarakhand and its use is rapidly increasing due to having no side effects, easily available at affordable prices. Field surveys were conducted in the various villages/places in Nainital district between 2013-2015. In general Itching, skin diseases, bleeding, foot and mouth disease, gastrointestinal helminthiasis, mange, myiasis, pain, pediculosis, pneumonia, tick infestation and uterine prolapsed, diarrhoea, afterbirth retention, poisoning, indigestion, liver problem, cough, fever, bone fracture were some common conditions/ailments of animals for which traditional ethno-veterinary prescriptions are usually being used in the area. The dependence of humans and livestock on this rich plant diversity is well known phenomenon since time immemorial. In present investigation a total of 38 plant species from 26 different families were recorded as Ethno-Veterinary plants from the study area. Out of 38 species 9 species were tree and rest all species were herbs. <strong>Keywords:</strong> Ethno-Veterinary Medicine (EVM), ethno-botanical information, Ethno-Veterinary plants, livestock, folk beliefs, socioeconomic value, Traditional hillers. <strong>REFERENCES</strong> Bahadur, J (2004). 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Vijayakumar S, MorvinYabesh J.E., Prabhu S, Manikandan R, and Muralidharan B, 2015. Quantitative ethnomedicinal study of plants used in the Nelliyampathyhills of Kerala, India. J. Ethnopharmacol. 161, 238&ndash;254. Webb EJ, Sechrest L, Campbell DT and Schwartz R (1966) Unobtrusive Measures: Nonreactive Research in the Social Sciences, 1st ed. Houghton-Mifflin, Boston, MA, 225 pp. Zobel, D.B aand Singh. S.P (1997) Himalayan forests and ecological generalizations. Bio Science, 11, 735&ndash;745.

Abstract— The solar energy is the most important type of energy. The parabolic dish solar collector (PDSC) is the best type among other solar collectors because it is always tracking the sun movement. The exergy and the energy performances of a PDS were analyzed experimentally and numerically. The effect of different coil geometries and different mass flow rates of heat transfer fluid (HTF) were investigated. The PDS has parabolic dish and receiver with diameter (1.5) m and (0.2) m respectively. Concentration ratio is 56.25. The parabolic polar dish was supported by a tracking system with two axes. The types of the copper absorber were used which are: (spiral –helical) coil (SHC) and spiral-conical coil (SCC). The results showed that the useful energy and thermal efficiency are varying with solar radiation variation. The useful energy varying between (480-765) W for (SHC), the thermal efficiency varying between (35.2-39.8) % for (SHC). Exergy efficiency varying between (6.9 –8.6) %. It was shown that the higher values of useful energy for (spiral – helical) absorber was 0.1L/min flow rate.&#x0D; REFERENCES &#x0D; 1. T. Taumoefolau , K. Lovegrove ," An Experimental Study of Natural Convection Heat Loss from a Solar Concentrator Cavity Receiver at Varying Orientation. ", Australian National University,, Canberra ACT 0200 AUSTRALIA.2002 &#x0D; 2. S. PAITOONSURIKARN and K. LOVEGROVE," On the Study of Convection Loss from Open Cavity Receivers in Solar Paraboloidal Dish Applications ", Australian National University Canberra ACT 0200, AUSTRALIA, pp 154,155,2003 &#x0D; 3. Soteris A. Kalogirou*,"Solar thermal collectors and applications", Higher Technical Institute, Progress in Energy and Combustion Science 30 (2004) 231–295, pp237, 240, 241, 2004 &#x0D; 4. M. Prakash, S.B. Kedare, J.K. Nayak," Investigations on heat losses from a solar cavity receiver", Department of Energy Science and Engineering, Indian Institute of Technology Bombay, Mumbai 400076, India,2008. &#x0D; 5. Shiva Gorjian1, Barat Ghobadian1, Teymour Tavakkoli Hashjin1, and Ahmad Banak ,"Thermal performance of a Point-focus Solar Steam Generating System ", 21st Annual International Conference on Mechanical Engineering-ISME201 7-9 May, 2013, School of Mechanical Eng., K.N.Toosi University, Tehran, Iran ,1ISME2013-1195,2013 &#x0D; 6. Kailash Karunakaran1 Hyacinth J Kennady2 ,"Thermal Analysis of Parabolic Dish Snow Melting Device " ,International Journal for Research in Technological Studies| Vol. 1, Issue 3, February 2014 | ISSN (online): 2348-1439,2014 &#x0D; 7. Charles-Alexis Asselineau, Ehsan Abbasi, John Pye "Open cavity receiver geometry influence on radiative losses" Australian National University (ANU), Canberra, ACT 0200 Australia. 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Stefanovi, Christos Tzivanidis and Zoran M. Stamenkovi "Design, Simulation ,and Optimiztion Of A Solar Dish Collector with spiral coil absorber ", , Nis, Serbia, thermal SCIENCE, Vol. 20, No. 4, pp. 1387-1397 1387,2016 &#x0D; 12. Flávia V. Barbosa, João L. Afonso, Filipe B. Rodrigues, and José C. F. Teixeir," Development of a solar concentrator with tracking system", University of Minho,Guimarães, 4800-058, Portugal2016 &#x0D; 13. O. López, A. Arenas, and A. Baños"Convective Heat Loss Analysis of a Cavity Receiver for a Solar Concentrator" International Conference on Renewable Energies and Power Quality (ICREPQ’17)Malaga (Spain), 4th to 6th April, 2017 ,ISSN 2172-038 X, No.15 April 2017 RE&amp;PQJ, Vol.1, No.15, April 2017 &#x0D; 14. D.R.Rajendran,E.GanapathySundaram,P.Jawahar "Experimental Studies on the Thermal Performance of a Parabolic Dish Solar Receiver with the Heat Transfer Fluids Sic water Nano Fluid and Water", Journal of Thermal Science Vol.26, &#x0D; 15. 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Abstract Background: Although colorectal cancer (CRC) screening reduces both CRC incidence and CRC-related mortality, it is underutilized, especially among those with lower socioeconomic status (SES) and in racial and ethnic minoritized populations who have been disproportionately impacted by COVID-19. The shift in healthcare priorities to contain and mitigate COVID-19 over the last few years reduced clinical capacity for non-urgent care, including CRC screening. This study aimed to assess the impact of COVID-19 on disparities in CRC screening. Methods: Blue Cross Blue Shield (BCBS) insures approximately one third of Americans. We leveraged BCBS Axis data to examine temporal patterns in CRC screening among individuals aged 45-75 years during 2017-2021, focusing on three periods: 1) first wave of COVID-19 outbreak (Mar-Apr 2020); 2) second wave of COVID-19 outbreak (i.e., the Delta variant, Jan-Feb 2021); and 3) the most recent 2-month interval for which data are available (Nov-Dec 2021). Both invasive and non-invasive CRC screening procedures were identified, and beneficiaries who received screening one year before were excluded. Screening rates within each 2-month interval were calculated. Neighborhood SES was assessed by Social Deprivation Index at the zip code level and categorized into quintiles. Results: The study cohort included 27,628,570 individuals. Throughout the 5-year period, except for the 1st wave of COVID-19 outbreak, screening rates were higher in areas with higher SES. Prior to the pandemic (Jan 2017–Feb 2020), the average bimonthly screening rate in areas with the highest SES was 2.1%, compared to 1.7% in areas with the lowest SES (p &amp;lt;0.001). During the 1st wave of COVID-19 outbreak, screening rate decreased to approximately 0.8% across all SES quintiles. During the 2nd wave of COVID-19 outbreak, screening rates were 1.7% and 1.3% in the highest and lowest SES areas, respectively. For the last 2-month interval in our study period (Nov-Dec 2021), screening rates increased to 2.4% and 1.8% in areas with the highest and lowest SES, respectively. Among 9,565,516 beneficiaries with known race and ethnicity, 8.0%, 11.0%, 3.3% and 0.4% were non-Hispanic Black, Hispanic/Latino, Asian, and Native Americans/Pacific Islanders, respectively. Across all racial and ethnic groups, the average bimonthly screening rate was 1.9% prior to the pandemic, 0.7% in Mar-Apr 2020, 1.5% in Jan-Feb 2021, and 2.1% in Nov-Dec 2021. Conclusion: After the onset of COVID-19, CRC screening rate decreased broadly and reached a similar level in all SES groups in early 2020, but it then recovered at a different pace for individuals with different SES, maintaining and even exacerbating inequities that existed prior to the pandemic. Screening patterns were comparable across different racial and ethnic groups who were privately insured through BCBS. Findings from this very large study may help inform interventions to address social and structural determinants of health and reduce the disproportionate burden of CRC in individuals residing in socially deprived areas. Citation Format: Arfan Siddique, Rong Wang, Jacquelyne Gaddy, Cary Gross, Xiaomei Ma. Impact of COVID-19 on colorectal cancer screening disparities: Results from a large commercially insured population in the United States [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr C129.

Abstract Background S. aureus, including MRSA, is a common colonizer of the nares. Recent data have shown that a negative MRSA nares screen by PCR has a negative predictive value of 98%. This implies that the absence of colonization can significantly reduce empiric vancomycin utilization. This study aimed to determine the utilization of MRSA nares screening on patients receiving vancomycin for respiratory tract infections (RTI) following the addition of the screen to the institutional RTI management guidelines. Methods This was a retrospective chart review of adult inpatients presenting to two community-teaching hospitals who were prescribed vancomycin for the treatment of RTIs. Patients were divided into pre-guideline (Jan-Feb 2019), post-guideline 1 (Jan-Feb 2020), and post-guideline 2 (Jan-Feb 2021) groups. The primary endpoint was the difference in percent of vancomycin orders discontinued within 24 hours of a negative screen. Secondary endpoints included the percent of screens ordered, re-initiation of vancomycin within seven days for RTI, and total vancomycin days of therapy (DOT) per 1000 patient days (PD). Results Of 493 vancomycin orders screened, 100 orders in each arm were analyzed. There was an absolute increase of 20.6% in vancomycin orders discontinued within 24 hours of a negative screen between the pre-guideline and post-guideline 2 groups (59.1% vs. 79.7%, p = 0.0177). When compared to the pre-guideline group, utilization of the screen increased by 15% in the post-guideline 1 group (48% vs. 63%, p = 0.0328) and 26% in the post-guideline 2 group (48% vs. 74%, p = 0.000164). There was no difference in re-initiation of vancomycin. A statistically significant reduction in total vancomycin DOT/1000PD from the pre-guideline to the post-guideline 1 and 2 groups (66 to 63 to 60, respectively) was also observed. Conclusion The addition of the MRSA nares screen to the institutional RTI guidelines increased utilization of the test and demonstrated a reduction in vancomycin utilization. With an increase in education, prospective audit and feedback, and prescriber comfort with the use of the MRSA nares screen in the post-guideline 2 group, there was significant improvement in MRSA nares screen utilization, vancomycin discontinuation after a negative screen, and vancomycin utilization. Disclosures All Authors: No reported disclosures

Call for Submissions for the Winter 2025 (Volume 16, No. 2) Special Issue of Cultural and Pedagogical Inquiry entitled Voices of the Forcibly Displaced: Transition, Resettlement and Education with Guest Co-Editors Marcela S. Duran, Jan Stewart, Don Dippo, Mohamed Duale and Cecille DePass.

Call for Submissions for the Summer 2025 (Volume 17, No. 1) Special Issue of Cultural and Pedagogical Inquiry entitled Voices of the Forcibly Displaced: Transition, Resettlement and Education with Guest Co-Editors Marcela S. Duran, Jan Stewart, Don Dippo, Mohamed Duale and Cecille DePass.

Analysis of the Jan 15, 2022 eruption of the Hunga Tonga water volcano leads to the conclusion that it is the actual cause of the 2023 El Nino. The mechanism is that the settling out of its moisture on the way down efficiently flushes out much of the industrial SO₂&nbsp;aerosol pollution in the troposphere, cleansing the air, and causing temperatures to rise. Although a natural event, the continued removal of SO₂ aerosols from our atmosphere by various activities will eventually have the same disastrous effect, which may already be beginning, according to a comparison of NASA/GMAO Chem maps of for Jan 1, 2020 versus Jan 1, 2023.

Call for Submissions for the Summer 2025 (Volume 17, No. 1) Special Issue of Cultural and Pedagogical Inquiry entitled Voices of the Forcibly Displaced: Transition, Resettlement and Education with Guest Co-Editors Marcela S. Duran, Jan Stewart, Don Dippo, Mohamed Duale and Cecille DePass. (This Call for Submissions is Closed)

An experiment was carried out at the Agronomy Field Laboratory of Bangladesh Agricultural University, Mymensingh during three consecutive seasons in 2004-2006 to find out the effect of sowing date on physiological quality of soybean seed. The experiments included six sowing dates viz. 4 Nov, 24 Nov, 14 Dec, 3 Jan, 23 Jan and 12 Feb and two cultivars namely G-2 and PB-1 in Rabi 2004-05; four sowing dates viz. 25 Jul, 14 Aug, 3 Sept and 23 Sept and three cultivars namely G-2, PB-1 and BS-5 in Kharif II 2005; four sowing dates viz. 26 Nov, 16 Dec, 5 Jan, and 25 Jan, and two cultivars viz. G-2 and PB-1 in Rabi 2005-06. The experiments were conducted in split-plot design with three replications. Results revealed that cultivar G-2 had higher germination and vigour than cultivar PB-1 or BS-5 in all the three seasons. November and December sowing produced seeds with higher germination and vigour for all the cultivars in Rabi season. On the other hand, September sowing produced seeds with high germination and vigour during Kharif II. The study indicated that soybean seeds with high germination and vigour could be obtained by sowing during November to December in Rabi season and August to September in Kharif-II season. DOI: http://dx.doi.org/10.3329/agric.v11i1.15245 The Agriculturists 2013; 11(1) 67-75

This study's purpose of contributing to the literature by empirically examining the effect of tax planning, activities, financial debt, audit quality, and firm investment on the firm value. This study adopts quantitative method research using panel regression with 1,264 data samples for model 1 and 1,291 data samples for model 2 with observation year from 2017-2021. This study shows that audit quality and tax planning have a significant positive impact on firm value. In contrast to firm investment, financial debt has a significant negative effect on firm value, which has insignificant results. This research contribution is that companies should pay attention to the selection of auditors for a financial audit because the auditor's role has a positive impact on the firm value. Also, investors can see the value of companies eligible for investment considering the tax planning activities in advance of the company carried out. The novelty of this research is the use of measurement of tax per share for tax planning, rarely used by the other researcher in conducting a relationship between firm value and tax planning. &#x0D; Public interest statement&#x0D; This study is necessary because the auditor's role is critical in minimizing the profit-making practices of managers and ensuring the quality of corporate earnings reporting. Investors can also pay attention to the value of a company worth investing in by paying attention to the tax planning activities undertaken by a company.&#x0D; Article history&#x0D; Received 26 Nov 2022 | Revised 10 Jan 2023 | Accepted 11 Jan 2023 | Online First 03 Feb 2023

AbstractIntroductionComprehensive care programs, which include individually planned pharmacotherapy are associated with higher rates of recovery1 and better long-term prognosis2. However, there are barriers to individually optimised antipsychotic treatment both from both the patients and treatment teams perspectives.ObjectivesTo summarize the potential contribution of adequate long-term antipsychotic treatment to recovery or better outcomes in schizophrenia.MethodReview of research data. Results A shorter duration of untreated psychosis, a lower number of relapses, and the absence of a chronic course of psychosis are associated with higher rates of recovery and a better prognosis. The OPUS early intervention program was associated with better outcomes for up to 10 years, but not for more than 20 years3. Second generation antipsychotics are associated with lower mortality rates, including suicides in young people with schizophrenia.4 Higher doses of antipsychotics are associated with poorer outcomes and with potential structural brain changes, while adequate (lower) doses of antipsychotics are associated with lower side effect burden and better overall outcomes5. A significant proportion of patient may benefit from polypharmacy (combination of 2 antipsychotics)6. Antipsychotic treatment discontinuation strategies are associated with the development of treatment resistance.7ConclusionsAdequate (low dose) antipsychotic treatment is part of the complex early intervention programs and long term treatment of schizophrenia, which are associated with higher rates of recovery and good outcomes. The role of polypharmacy (combination of 2 antipsychotics) may need a reconsideration in the treatment guidelines of schizophrenia.1.Kane JM et al. The Journal of clinical psychiatry. 2015 Mar 25;76(3):16590.2.Posselt CM et al. 2021. American Journal of Psychiatry, 2021, 178(10):941-9513.Hansen HG et al. 2023. JAMA Psychiatry, 2023, 80(4): 371-379.4.Correll CU et al. World Psychiatry. 2022 Jun;21(2):248-71.5.Andreasen NC et al. 2013 Jun;170(6):609-15.6.Katona L et al. 2014 Jan 1;152(1):246-54.7.Emsley R et al2013 Feb 1;33(1):80-3.Disclosure of InterestNone Declared

The study was conducted during rabi-2021 (Jan, 2021–Feb, 2021) and late kharif (Sept, 2021–Feb, 2022) at JAU, Junagadh, Gujarat to study the G×E interaction and stable genotype over environments (Seven parents (GJB-2, GJB-3, GRB-5, JBCL-10-12, JBCL-16-12, JBCL-17-01 and Swarna Mani Black SB) were intermated in full diallel fashion to obtain 42 hybrids (including reciprocals) , and evaluated in three environments viz., normal fertilizer (E1, 100:50:50 NPK, kg ha-1), at Vegetable research station, organic condition (E2, well rotten FYM+Vermicompost) and 25% high fertilizer dose (E3, 125: 62.5: 62.5 NPK, kg ha-1) at Instruction farm of Agronomy, JAU, Junagadh, Gujarat, India in Randomized Block Design (RBD) with three replications . The mean sum of squares due to genotype (G), environment (E), G×E interaction and E+(G×E) obtained significant for all the traits indicating that characters significantly interacted in different environments and environment created by different dose of fertilizer was justified. The environment index indicated that normal fertilizer environment was best suited for most of traits and organic environment suited for TSS content. Phenotypic stability analysis revealed that stable genotypes GRB-5 and GJB-2×GRB-5 and GRB-5×SB for days to first flowering, GJBH-4, GJB-2×SB, GJB-3×GJB-2 and SB×GJB-2 for days to first picking, SB×JBCL-16-12 for fruit girth, JBCL-17-01× GJB-2 for number of fruits plant-1 and GJB-3, GRB-5 and GJB-3×SB for TSS content over environments. GRB-5×JBCL-16-12 suitable for better environment for fruit yield plant-1. None of the parent and cross found stable for fruit yield plant-1 over environments suggested that environment difference was wider and genotypes stable for other traits can be used in future breeding programme for developing stable genotypes.

Editorial – Revista Ambiente Contábil – Volume 14 – Número 1 – Ano 2022 (Jan./Jun. 2022)&#x0D; A Revista Ambiente Contábil (Ambiente) apresenta na sua 27ª edição 19 (dezenove) artigos que tratam de assuntos relevantes para a área contábil; 01 (uma) resenha de livro e 15 (quinze) artigos no idioma inglês (versão de artigos submetidos em português).&#x0D; Seção 1: Contabilidade Aplicada ao Setor Empresarial&#x0D; Artigo 1 - Aplicabilidade dos modelos CAPM local, CAPM local ajustado e CAPM ajustado híbrido ao mercado brasileiro de Vandliny Paiva Martins Teixeira, Moisés Ferreira da Cunha e Thaisa Renata dos Santos com o objetivo de verificar a aplicabilidade dos modelos CAPM local, CAPM Local Ajustado e CAPM Ajustado Híbrido ao mercado brasileiro, a partir da análise de suas respectivas premissas e, adicionalmente, verificar a existência de diferenças estatísticas significativas entre os modelos.&#x0D; Artigo 2 - Gerenciamento de resultados e de capital por bancos latino-americanos com instrumentos financeiros José Alves de Carvalho, Júlio César Gomes Mendonça, Maurício Soares de Faria Júnior e José Alves Dantas com o objetivo de avaliar se os bancos da América Latina utilizam os ganhos e perdas não realizados com instrumentos financeiros, registrados como outros resultados abrangentes, com o objetivo de gerenciamento de resultados e de capital regulatório.&#x0D; Artigo 3 - Cultura organizacional e desempenho financeiro: evidências em empresas listadas no Índice Brasil 100 de Leonardo Portella Ilowski, Iago França Lopes, Cintia Lopes da Silva Vieira, Danieli de Assis Machado, Ruberval Gonçalves de Matos e Nayane Thais Krespi Musial com o objetivo de analisar a relação entre cultura organizacional e desempenho financeiro de empresas listadas no IBrX 100.&#x0D; Artigo 4 - Impacto da exclusão do ICMS da base de cálculo do PIS e da COFINS: estudo sobre a decisão do STF e seus efeitos em uma empresa do segmento alimentício de Jéssica Andressa Zago, Letícia Twardowski da Silva e Vitor Paulo Rigo com o objetivo de apresentar o impacto da decisão proferida pelo Supremo Tribunal Federal que exclui o ICMS da base de cálculo do PIS e da COFINS e demonstrar o montante dessas contribuições a serem restituídas por uma empresa do setor alimentício, enquadrada no regime do Lucro Real.&#x0D; Artigo 5 - Práticas de responsabilidade socioambiental e o desempenho organizacional em companhias abertas de Naline Tres, Claudia Dalla Porta, Sady Mazzioni, Cristian Bau Dal Magro e Daniela Di Domenico com o objetivo de analisar a relação entre as práticas de responsabilidade socioambiental no desempenho das companhias abertas listadas na [B3].&#x0D; Artigo 6 - Agressividade tributária nas empresas de capital aberto que atuam em mercado regulado de Thaís Salvatori França e Francisco Antonio Bezerra com o objetivo de identificar se o mercado regulado por intermédio de suas agências é fator determinante para uma postura de menor agressividade tributária nas empresas.&#x0D; Artigo 7 - Avaliação da condição econômico-financeira de operadoras brasileiras de planos de saúde: uma nota sobre finanças e regulação de Carlos Henrique Rocha, Gladston Luiz da Silva e Paulo Augusto Pettenuzzo de Britto com o objetivo de avaliar o desempenho econômico-financeiro de operadoras brasileiras de planos de saúde e investigar possíveis fontes de variações relativas dos índices estudados. O artigo discute, ainda, a questão da regulação a partir da análise econômico-financeira dos entes regulados.&#x0D; Artigo 8 - O impacto do uso da tecnologia no desempenho da produção leiteira: manejo tradicional, compost barn e free stall de Ana Maria Meinl e Euselia Paveglio Vieira com o objetivo de analisar a contribuição do uso de tecnologias e sistemas de produção diferenciados na formação dos resultados da atividade leiteira de três propriedades rurais, que utilizam diferentes sistemas produtivos e estão localizadas na região Noroeste do Estado do Rio Grande do Sul.&#x0D; Artigo 9 - Análise da relação da quantidade de participantes ativos das entidades fechadas de Previdência Complementar (EFPC) com o ambiente socioeconômico de Ivone Pedro de Lima, Elis Regina de Oliveira, Geovane Camilo dos Santos, Dryelle Laiana de Jesus Silva dos Santos e Élcio Dihl Oliveira com o objetivo de analisar a associação entre a quantidade de participantes ativos de planos de previdência, vinculados às EFPC, e as variáveis: PIB, taxa de desocupação, inflação (INPC), taxa de juros (Selic), quantidade de EFPC e fluxo de entrada e saída de participantes ativos.&#x0D; Artigo 10 - Transparência corporativa e desempenho: qual o papel das mulheres nessa relação? de Verivaldo Alves de Freitas, Messias Elmiro Gomes Loiola de Oliveira, Jislene Trindade Medeiros e Márcia Martins Mendes De Luca com o objetivo de investigar a influência da participação feminina no conselho de administração na relação entre a transparência corporativa e o desempenho de empresas brasileiras.&#x0D; Artigo 11 - Análise da viabilidade econômica, em condições de riscos, do sistema de confinamento utilizado para a terminação de bovinos no estado de São Paulo, Brasil de Kaio Expedito Rodrigues Queiroz, Janderson Damaceno dos Reis e André Rozemberg Peixoto Simões com o objetivo de avaliar a sensibilidade e a viabilidade econômica do sistema de confinamento utilizado para a engorda de bovinos tomando como referência uma propriedade localizada no norte do estado de São Paulo, Brasil.&#x0D; &#x0D; Artigo 12 - Avaliação do nível de disclosure de arrendamentos mercantis nas demonstrações contábeis de empresas de consumo não-cíclico: um estudo sob a luz do novo IFRS 16 de Ícaro Luiz de Sousa Silva, Alexandre Gonzales e Fernando de Almeida Santos com o objetivo de averiguar o nível de disclosure contábil demandado de acordo com o IFRS16 nas empresas de capital aberto na B3, mais precisamente no segmento de consumo não-cíclico.&#x0D; Artigo 13 - Desempenho dos maiores bancos brasileiros: um estudo sobre o impacto da crise subprime de Cristiana Maria Coeli e Vanessa Martins Pires com o objetivo de analisar o impacto da crise subprime no desempenho dos maiores bancos brasileiros, utilizando indicadores contábeis que permitem mensurar o comportamento dos índices de inadimplência, a evolução das despesas com Provisão para Devedores Duvidosos (PDD), do volume de ativos totais e dos índices de rentabilidade.&#x0D; Seção 2: Contabilidade Aplicada ao Setor Público e ao Terceiro Setor&#x0D; Artigo 1 - Emenda Constitucional n.º 95/2016 e seu impacto em uma universidade federal de Viviane Amorim de Oliveira, Eduardo Tadeu Vieira, Tiago Mota dos Santos e Jorge Katsumi Niyama com o objetivo de avaliar, em um cenário hipotético e por meio de abordagem retrospectiva, no período de 1995 a 2017, os efeitos da Emenda Constitucional n.º 95/2016 sobre o orçamento da Universidade de Brasília, a partir de um modelo econométrico de previsão de despesa paga.&#x0D; Artigo 2 - Impactos na eficiência do gasto público na educação fundamental dos municípios paulistas por meio das categorias do elemento da despesa de Gabriel Santana Machado, Jaime Crozatti, Vinicius Macedo de Moraes, Bianca de Oliveira e Carlos Eduardo de Oliveira Silva com o objetivo de mensurar os impactos dos gastos públicos na educação fundamental dos municípios paulistas sobre a eficiência do gasto público educacional.&#x0D; Artigo 3 - Eficiência do sistema de transporte metroferroviário brasileiro: uma aplicação da Análise Envoltória de Dados de Maria Cecilia da Silva Brum e Tiago Wickstrom Alves com o objetivo de analisar a eficiência técnica das empresas metroferroviárias brasileiras.&#x0D; &#x0D; Seção 3: Pesquisas de Campo sobre Contabilidade (Survey)&#x0D; Artigo 1 - Controles internos para o gerenciamento de riscos: percepção de auditores e gestores de Isadora Marques dos Santos, Rosângela Queiroz Souza Valdevino, Rosilania Silva de Queiroz, Adriana Martins de Oliveira, Letícia Jéssica Freitas de Oliveira e Meskla Gislainy Marques da Silva com o objetivo de analisar a percepção dos auditores e gestores em relação aos controles internos no gerenciamento de riscos nas empresas.&#x0D; Artigo 2 - Sistema eletrônico de informações em uma instituição pública do estado de Pernambuco: uma análise da aceitação e uso do sistema de Antônio Alves da Silva, Paulo de Tasso de Souza Junior e Alessandra Carla Ceolin com o objetivo de promover uma avaliação da aceitação e uso da tecnologia implantada (Sistema Eletrônico de Informações) em uma instituição pública do estado de Pernambuco, sob a perspectiva dos usuários internos do sistema à luz da Teoria Unificada de Aceitação e Uso da Tecnologia (Venkatesh, Morris, Davis &amp; Davis, 2003).&#x0D; Artigo 3 - Avaliação da utilização do Portal Capes de periódicos na ótica dos usuários pesquisadores em administração e contabilidade com base na escala SERVQUAL de Ana Carolina Vasconcelos Colares e Cássia de Oliveira Ferreira com o objetivo de avaliar a utilização do Portal Capes de Periódicos na ótica dos usuários pesquisadores em administração e contabilidade, e investigar a relação entre a satisfação do usuário com as cinco dimensões do modelo SERVQUAL de avaliação de serviços.&#x0D; Seção 4: Casos de Ensino Aplicados a Contabilidade&#x0D; Não houve submissão.&#x0D; Seção 5: Resenhas de Teses, Dissertações e Livros sobre Contabilidade&#x0D; Resenha 1 - Resenha do livro: Escola Nacional de Administração Pública (ENAP). Capacidades Estatais para Produção de Políticas Públicas: Resultados do Survey sobre o Serviço Civil no Brasil. Brasília: Enap, 2018, 74 páginas, Cadernos Enap, 56, ISSN: 0104-7078&#x0D; Autores: Everaldo Nogueira de Souza e Antônio Carlos Brunozi Júnior&#x0D; Seção 6: Banco de Dados (Arquivos suplementares em Excel)&#x0D; Não houve submissão.&#x0D; Seção 7: Internacional (S7)&#x0D; ENGLISH&#x0D; Section 1&#x0D; Article 2 (Section 1) – Earnings and capital management by Latin American banks through financial instruments of José Alves de Carvalho, Júlio César Gomes Mendonça, Maurício Soares de Faria Júnior and José Alves Dantas. The purpose of this study is to assess whether banks in Latin America make use of unrealized gains and losses through financial instruments, recorded as other comprehensive income, when engaging in earnings management and capital resource allocation.&#x0D; Article 3 (Section 1) – Organizational culture and financial performance: evidence in companies listed in the Brazil Index 100 of Leonardo Portella Ilowski, Iago França Lopes, Cintia Lopes da Silva Vieira, Danieli de Assis Machado, Ruberval Gonçalves de Matos and Nayane Thais Krespi Musial. The study investigates the relationship between organizational culture and financial performance of companies classified in the IBrX 100.&#x0D; Article 4 (Section 1) - Impact of the exclusion of ICMS from PIS and COFINS calculation base: study on the STF decision and its effects on a food company of Jéssica Andressa Zago, Letícia Twardowski da Silva e Vitor Paulo Rigo. This study aims to present the impact of the decision issued by the Supreme Federal Court that excludes ICMS from PIS and COFINS calculation basis and to present the amount of these contributions to be refunded by a company in the food sector, within the framework of the actual profit method.&#x0D; Article 5 (Section 1) - Socio environmental responsibility practices and organizational performance in public companies of Naline Tres, Claudia Dalla Porta, Sady Mazzioni, Cristian Bau Dal Magro and Daniela Di Domenico. Analyze the relationship between socio-environmental responsibility practices in the economic and financial performance of companies listed in [B3].&#x0D; Article 6 (Section 1) - Tax aggressiveness in publicly traded companies operating in a regulated market of Thaís Salvatori França and Francisco Antonio Bezerra. The research aims to identify whether the regulated market through its agencies is a determining factor for a posture of less tax aggressiveness in companies.&#x0D; Article 7 (Section 1) – An appraisal of Brazilian private health plan operators’ economic-financial conditions: a note on finance and regulation of Carlos Henrique Rocha, Gladston Luiz da Silva and Paulo Augusto Pettenuzzo de Britto. This study aims to evaluate the economic-financial performance of Brazilian private health plan operators and investigate possible sources of relative variations in the studied indicators. The article also discusses the question of regulation based on an economic-financial analysis of the regulated entities.&#x0D; Article 8 (Section 1) – The impact of using technology on the performance of dairy production: traditional management, compost barn and free stall of Ana Maria Meinl and Euselia Paveglio Vieira. This theoretical application seeks to analyze the contribution of the use of differentiated technologies and systems in the formation of the results of the dairy activity of three rural properties, which use different productive systems and are located in the Northwest region of the State of Rio Grande do Sul. Calculation of costs of the three properties using the absorption costing method, in order to know the respective results in each production system analyzed. &#x0D; &#x0D; Article 10 (Section 1) – Corporate transparency and performance: what is the role of women in this relationship? of Verivaldo Alves de Freitas, Messias Elmiro Gomes Loiola de Oliveira, Jislene Trindade Medeiros e Márcia Martins Mendes De Luca. In this study, we investigated the influence of female board membership on the relationship between corporate transparency and performance in Brazilian public firms.&#x0D; Article 11 (Section 1) – Analysis of economic viability under risk conditions of a beef cattle feedlot system in São Paulo State, Brazil of Kaio Expedito Rodrigues Queiroz, Janderson Damaceno dos Reis e André Rozemberg Peixoto Simões. Assess the sensitivity and economic viability of the beef cattle feedlot system using as a reference a farm located in northern São Paulo State, Brazil.&#x0D; Article 12 (Section 1) – Disclosure analysis of leases in financial statements of non-cyclical consumer companies: a study considering IFRS 16 of Ícaro Luiz de Sousa Silva, Alexandre Gonzales and Fernando de Almeida Santos. This article then aims to ascertain the level of accounting disclosure required under the IFRS 16 in publicly traded companies in B3, more precisely in the non-cyclical consumer segment. &#x0D; Section 2&#x0D; Article 1 (Section 2) - Constitutional Amendment 95/2016 and its impact on a federal university of Viviane Amorim de Oliveira, Eduardo Tadeu Vieira, Tiago Mota dos Santos and Jorge Katsumi Niyama. To evaluate the effects of Constitutional Amendment 95/2016 on the budget of the University of Brasília in the period from 1995 to 2017, based on an econometric model for forecasting expenditure, using a hypothetical scenario and a retrospective approach.&#x0D; Article 2 (Section 2) - Impacts on the efficiency of public expenditure in the fundamental education of São Paulo cities through the expenditure element categories of Gabriel Santana Machado, Jaime Crozatti, Vinicius Macedo de Moraes, Bianca de Oliveira and Carlos Eduardo de Oliveira Silva. This study aims to measure the impact of public spending on basic education in São Paulo cities on the efficiency of public educational expenditure.&#x0D; Article 3 (Section 2) - The efficiency of Brazilian railway system: an application of Data Envelopment Analysis of Maria Cecilia da Silva Brum and Tiago Wickstrom Alves. To analyze the technical efficiency of Brazilian railway companies. &#x0D; Section 3&#x0D; Article 1 (Section 3) - Internal controls for risk management: perception of auditors and managers of Isadora Marques dos Santos, Rosângela Queiroz Souza Valdevino, Rosilania Silva de Queiroz, Adriana Martins de Oliveira, Letícia Jéssica Freitas de Oliveira and Meskla Gislainy Marques da Silva. This article aims to analyze the perception of auditors and managers in relation to internal controls in risk management in companies.&#x0D; Article 3 (Section 3) - Evaluation of the use of the Capes Portal of journals from the perspective of research users in administration and accounting based on the SERVQUAL scale of Ana Carolina Vasconcelos Colares and Cássia de Oliveira Ferreira. The objective of this research is to evaluate the use of the Capes Portal of Periodicals from the perspective of research users in administration and accounting, and to investigate the relationship between user satisfaction with the five dimensions of the SERVQUAL model of service evaluation.&#x0D; &#x0D; Boa leitura. Cordiais saudações!&#x0D; &#x0D; Prof. Dr. Maurício Corrêa da Silva&#x0D; Editor Gerente da Revista Ambiente Contábil&#x0D;

A Revista Ambiente Contábil (Ambiente) apresenta na sua 23ª edição 16 (dezesseis) artigos que tratam de assuntos relevantes para a área contábil; 02 (duas) resenhas de livros; 04 (quatro) bancos de dados brutos de pesquisa; 06 (seis) artigos no idioma inglês e 02 (dois) no idioma espanhol.&#x0D; Seção 1: Contabilidade Aplicada ao Setor Empresarial&#x0D; Artigo 1 - Nível de aderência das empresas brasileiras listadas do setor de telecomunicações ao pronunciamento contábil CPC 47 de Rafael Xavier de Oliveira, Thais Mota Crabbi e Jomar Miranda Rodrigues com o objetivo de analisar o nível de aderência (compliance) das empresas brasileiras do setor de telecomunicações listadas na B3 ao pronunciamento contábil CPC 47.&#x0D; Artigo 2 - O impacto da adoção do IFRS 9 (CPC 48) nas perdas esperadas em crédito de liquidação duvidosa (PECLD) nas empresas brasileiras do setor de energia elétrica de Aline Thatyana Aranda da Rocha Branco Alcantara Alves, Maria Paula Ribeiro Bordin, Alexandre Gonzales e Fernando de Almeida Santos com o objetivo de ddentificar o impacto da adoção do IFRS 9 (CPC 48) nas Perdas Esperadas em Crédito de Liquidação Duvidosa (PECLD) antes baseadas em perdas históricas conforme o CPC 38.&#x0D; Artigo 3 - Determinantes dos fluxos de caixa de financiamento: um estudo iniciado sob a ótica da concentração acionária de Manuela Gonçalves Barros, Marina Oliveira Gomes, Jéssica Duarte de Andrade Teixeira, Kálita Santos Sá com o objetivo de verificar se a concentração acionária é um determinante dos fluxos de caixa de financiamento, buscando também identificar o impacto de outras determinantes sobre estes fluxos.&#x0D; Artigo 4 - A eficiência relativa das empresas brasileiras distribuidoras de energia elétrica de Chelida Maria dos Santos Bastos, Denise Maria Moreira Chagas Corrêa, Ana Lua Vilanova Alves, Ana Carolina Pereira Rodrigues e Sueli Maria de Araújo Cavalcante com o objetivo de examinar a eficiência relativa dos desempenhos econômico-financeiros das companhias brasileiras abertas e fechadas distribuidoras de energia elétrica.&#x0D; Artigo 5 - Disclosure nos relatórios de sustentabilidade de empresas do novo mercado da Bovespa em consonância com os objetivos de desenvolvimento sustentável publicados pela ONU de Larissa dos Reis, Vitor Paulo Rigo e Kemylli Farion com o objetivo de analisar se os relatórios de sustentabilidade divulgados pelas empresas, listadas no segmento do novo mercado da BOVESPA, estão alinhados com os objetivos de desenvolvimento sustentável publicados pela ONU.&#x0D; Artigo 6 - Provável, possível ou remoto? Um estudo acerca das contingências tributárias dos bancos brasileiros de Matheus Schmitt, Ernando Fagundes e Alex Mussoi Ribeiro com o objetivo de identificar fatores determinantes na classificação das provisões e passivos contingentes nas Instituições Financeiras Brasileiras.&#x0D; Artigo 7 - O ensino de ciências contábeis e o processo de convergência ao international financial reporting standards de Giovana Bolzan, Maria Ivanice Vendruscolo, Jonatas Dutra Sallaberry e Willian Diehl com o objetivo de analisar o ensino de ciências contábeis diante da convergência aos padrões internacionais de contabilidade, sob a perspectiva da produção científica. &#x0D; Artigo 8 - Relação entre as características do comitê de auditoria e da auditoria independente das companhias abertas da B3 de Ana Carolina Vasconcelos Colares, Karinne Cruz Alves e Lidiane Tereza Fagundes Miranda com o objetivo de Investigar se existe relação entre as características do Comitê de Auditoria (tamanho; expertise; independência; participação feminina) constituído com as características da Auditoria Independente: (Audit Report Lag; Big Four; quantidade de principais assuntos de auditoria; opinião da auditoria no relatório), sendo essa análise realizada com as características de forma agregada e isolada.&#x0D; Seção 2: Contabilidade Aplicada ao Setor Público e ao Terceiro Setor&#x0D; Artigo 1 - Evidenciação contábil das entidades sem fins lucrativos de assistência social em Feira de Santana (BA): abordagem à luz das normas brasileiras de contabilidade de Acmar Feliz dos Santos de Santana e Tânia Cristina Azevedo com o objetivo de analisar a conformidade da evidenciação contábil das Organizações sem Finalidade de Lucros (OSFL), portadoras de Certificado de Entidade Beneficente de Assistência Social (CEBAS) em Feira de Santana (BA), à luz das Normas Brasileiras de Contabilidade, mediante adoção da Interpretação Técnica Geral - ITG 2002 (R1).&#x0D; Artigo 2 - As informações contábeis dos balanços versus os indicadores de satisfação de usuários: os casos do Metrô e da CPTM em São Paulo de Bruna de Morais Holanda, Lucas Custódio Alexandrino e Jaime Crozatti com o objetivo de verificar se existe relação entre os dados contábeis e a satisfação dos usuários relativos à política de transporte sobre trilhos na Região Metropolitana de São Paulo (RMSP) pela análise de informações de demonstrativos contábeis e da satisfação dos usuários das empresas públicas Companhia do Metropolitano de São Paulo (Metrô) e Companhia Paulista de Trens Metropolitano (CPTM), de 2010 a 2017.&#x0D; Artigo 3 - Mapeamento de competências: necessidades de aprimoramento de analistas periciais em contabilidade do Ministério Público Federal de Ariel Prates, Jonatas Dutra Sallaberry, Leonardo Flach, Ivam Ricardo Peleias e Romina Batista de Lucena de Souza com o objetivo de analisar as competências dos analistas da área pericial contábil lotados no Ministério Público Federal (MPF), de forma a apresentar aquelas que possuem maior necessidade de aprimoramento por nível de importância, domínio e impacto.&#x0D; Artigo 4 - O nível de disclosure em Organizações do Terceiro Setor (OTS) no Estado do Ceará de Roberto Sérgio do Nascimento, Mirela Márjorie Silva Rabelo e Ricardo Viotto com o objetivo de avaliar o nível de disclosure apresentado pelas Organizações do Terceiro Setor no Estado do Ceará em relação aos usuários externos, como forma de reduzir a assimetria informacional entre os agentes internos e externos em alusão à Teoria da Agência.&#x0D; Artigo 5 - O aumento do imposto sobre a propriedade de veículo automotores em tempo de recessão econômica e o reflexo na sua arrecadação de Lauro Vinício de Almeida Lima, Josedilton Alves Diniz e Márcia Reis Machado com o objetivo de analisar o comportamento da arrecadação do Imposto sobre a Propriedade de Veículos Automotores (IPVA) em relação ao aumento de suas alíquotas ocorrido no ano de 2016, durante a recessão econômica brasileira iniciada no final de 2014.&#x0D; Artigo 6 - Indicadores de desenvolvimento sustentável das mesorregiões catarinenses: uma análise comparativa de Luana Caroline da Silva e de Fabricia Silva da Rosa com o objetivo de analisar o desempenho sustentável das mesorregiões catarinenses a partir dos indicadores de desenvolvimento sustentável propostos pela Federação Catarinense de Municípios (FECAM).&#x0D; Seção 3: Pesquisas de Campo sobre Contabilidade (Survey)&#x0D; Artigo 1 - Percepção da corrupção em ambiente acadêmico: análise empírica a partir de alunos do curso de Ciências Contábeis da Universidade Federal do Ceará (UFC) de Roberto Sérgio do Nascimento e Ruth Carvalho de Santana Pinho com o objetivo de analisar aspectos significativos do perfil social que influenciam a percepção da corrupção por parte dos alunos de Ciências Contábeis da Universidade Federal do Ceará.&#x0D; Artigo 2 - Método do caso: um relato sobre sua efetividade e aplicabilidade no ensino de contabilidade de Alessandro Henrique de Araújo Januário, Cássia Marcelle Dias Pinho, Tadeu Junior de Castro Gonçalves e Aneide Oliveira Araújo com o objetivo de investigar a efetividade e a aplicabilidade do método do caso junto a alunos do mestrado em ciências contábeis da Universidade Federal do Rio Grande do Norte (UFRN).&#x0D; Seção 4: Casos de Ensino Aplicados a Contabilidade&#x0D; Não houve submissão.&#x0D; Seção 5: Resenhas de Teses, Dissertações e Livros sobre Contabilidade&#x0D; Resenha 1: Resenha do Livro: Análises das demonstrações contábeis públicas. Silva, M. C. (2019). (1a ed). São Paulo, SP: Editora Biblioteca 24Horas, 132 páginas, ISBN: 978-85-4161-395-8.&#x0D; Autora da resenha: Camila Rafaelly da Silva Câmara Revorêdo&#x0D; Resenha 2: Resenha do Livro: Auditoria governamental. Silva, M. C., Silva, R. A., &amp; Silva, J. D. G. (2019). (1a ed). São Paulo, SP: Editora Biblioteca 24Horas, 86 páginas, ISBN: 978-85-4161-389-7.&#x0D; Autora da resenha: Edna Maria da Silva Medeiros de Oliveira &#x0D; Seção 6: Banco de Dados (Arquivos suplementares em Excel)&#x0D; Artigo 1 da Seção 1 - Nível de aderência das empresas brasileiras listadas do setor de telecomunicações ao pronunciamento contábil CPC 47 de Rafael Xavier de Oliveira, Thais Mota Crabbi e Jomar Miranda Rodrigues com o objetivo de analisar o nível de aderência (compliance) das empresas brasileiras do setor de telecomunicações listadas na B3 ao pronunciamento contábil CPC 47.&#x0D; Artigo 3 da Seção 1 - Determinantes dos fluxos de caixa de financiamento: um estudo iniciado sob a ótica da concentração acionária de Manuela Gonçalves Barros, Marina Oliveira Gomes, Jéssica Duarte de Andrade Teixeira, Kálita Santos Sá com o objetivo de verificar se a concentração acionária é um determinante dos fluxos de caixa de financiamento, buscando também identificar o impacto de outras determinantes sobre estes fluxos.&#x0D; Artigo 2 da Seção 2 - As informações contábeis dos balanços versus os indicadores de satisfação de usuários: os casos do Metrô e da CPTM em São Paulo de Bruna de Morais Holanda, Lucas Custódio Alexandrino e Jaime Crozatti com o objetivo de verificar se existe relação entre os dados contábeis e a satisfação dos usuários relativos à política de transporte sobre trilhos na Região Metropolitana de São Paulo (RMSP) pela análise de informações de demonstrativos contábeis e da satisfação dos usuários das empresas públicas Companhia do Metropolitano de São Paulo (Metrô) e Companhia Paulista de Trens Metropolitano (CPTM), de 2010 a 2017.&#x0D; Artigo 6 da Seção 2 - Indicadores de desenvolvimento sustentável das mesorregiões catarinenses: uma análise comparativa de Luana Caroline da Silva e de Fabricia Silva da Rosa com o objetivo de analisar o desempenho sustentável das mesorregiões catarinenses a partir dos indicadores de desenvolvimento sustentável propostos pela Federação Catarinense de Municípios (FECAM).&#x0D; Seção 7: Internacional (S7)&#x0D; English&#x0D; Section 1&#x0D; Article 1 - Level of adherence of the brazilian listed companies of the telecommunications sector to the accounting pronouncement CPC 47 of the Rafael Xavier de Oliveira, Thais Mota Crabbi and Jomar Miranda Rodrigues. The present work sought to analyze the level of compliance of the Brazilian companies in the telecommunications sector listed in B3 to accounting pronouncement CPC 47.&#x0D; Article 2 – The impact from adapting of the IFRS 9 (CPC 48) on expected credit losses (ECL) in Brazilian energy companies of the Aline Thatyana Aranda da Rocha Branco Alcantara Alves, Maria Paula Ribeiro Bordin, Alexandre Gonzales and Fernando de Almeida Santos. To identify the IFRS 9 (CPC 48) adoption impact on Expected Credit Losses, based on historical losses under CPC 38.&#x0D; Article 7 - Accounting teaching and the convergence process to international financial reporting standards of the Giovana Bolzan, Maria Ivanice Vendruscolo, Jonatas Dutra Sallaberry and Willian Diehl. The research analyzes the teaching of accounting sciences in view of the convergence with international accounting standards, from the perspective of scientific production.&#x0D; Section 2&#x0D; Article 3 - Competency mapping: improvement needs of analysts from the area of expertise in accounting at the Federal Public Ministry of the Ariel Prates, Jonatas Dutra Sallaberry, Leonardo Flach, Ivam Ricardo Peleias and Romina Batista de Lucena de Souza. The study aims to analyze the skills of expert accounting analysts in the Brazilian Federal Public Ministry.&#x0D; Article 6 - Indicators of sustainable development of Santa Catarina mesoregions: a comparative analysis of the Luana Caroline da Silva and Fabricia Silva da Rosa. This study aims to analyze the sustainable performance of Santa Catarina mesoregions from the sustainable development indicators proposed by the Santa Catarina Federation of Municipalities (FECAM).&#x0D; Section 3&#x0D; Article 1 – Perception of corruption in academic environment: empirical analysis from Accounting students at the Federal University of Ceará (UFC) of the Roberto Sérgio do Nascimento e Ruth Carvalho de Santana Pinho. The present work aims to analyze significant aspects of the social profile that influence the perception of corruption by Accounting students at the Federal University of Ceará.&#x0D; Español&#x0D; Sección 1&#x0D; Articulo 7 - Enseñanza de ciencias contables y el proceso de convergencia a las international financial reporting standards de Giovana Bolzan, Maria Ivanice Vendruscolo, Jonatas Dutra Sallaberry e Willian Diehl. La investigación analiza la enseñanza de las ciencias contables en vista de la convergencia con los estándares internacionales de contabilidad, desde la perspectiva de la producción científica.&#x0D; Sección 2&#x0D; Articulo 1 - Evidenciación contable de las organizaciones sin fines lucrativos de asistencia social en Feira de Santana (BA): enfoque de acuerdo con las normas brasileñas de contabilidad de Acmar Feliz dos Santos de Santana y Tânia Cristina Azevedo. El trabajo tenía como objetivo analizar la conformidad de la divulgación contable de las Organizaciones sin Ánimo de Lucro (en Brasil OSFL), poseedoras del Certificado de Entidad Benéfica de Asistencia Social (CEBAS) en Feira de Santana (BA), de acuerdo con las Normas Brasileñas de Contabilidad, y mediante la adopción de la Interpretación Técnica General – ITG 2002 (R1).&#x0D; Boa leitura. Cordiais saudações!&#x0D; Prof. Dr. Maurício Corrêa da Silva&#x0D; Editor Gerente da Revista Ambiente Contábil

Editorial – Revista Ambiente Contábil – Volume 13 – Número 1 – Ano 2021 (Jan./Jun. 2021)&#x0D; A Revista Ambiente Contábil (Ambiente) apresenta na sua 25ª edição 20 (vinte) artigos que tratam de assuntos relevantes para a área contábil (idioma português); 01 (uma) resenha de livro; 04 (quatro) bancos de dados brutos de pesquisa e 10 (dez) artigos no idioma inglês.&#x0D; Seção 1: Contabilidade Aplicada ao Setor Empresarial&#x0D; Artigo 1 - Análise envoltória de dados para avaliação da eficiência financeira das cooperativas de eletrificação do sul do Brasil de Mariane Martins Scheffer, Januário José Monteiro, João Vanio Mendonça Cardoso e Cleyton de Oliveira Ritta com o objetivo de analisar a eficiência financeira das cooperativas de eletrificação localizadas na região sul do Brasil, no período entre 2012 a 2016.&#x0D; Artigo 2 - Os princípios subjacentes às IFRS e as bases de mensuração dos elementos integrantes das demonstrações financeiras de Camila Teresa Martucheli e Antônio Dias Pereira Filho com o objetivo de apresentar conceitos, argumentos e discussões acerca da adoção e utilização das IFRS, com foco em seus princípios subjacentes e bases de mensuração.&#x0D; Artigo 3 - Benefícios do uso da tecnologia blockchain como instrumento para a auditoria contábil de Maervelym Pâmella de Andrade Simões, Janeide Albuquerque Cavalcanti, Janaina Ferreira Marques de Melo e Cristiane Queiroz Reis com o objetivo de analisar quais os possíveis benefícios do uso da tecnologia Blockchain como instrumento para a auditoria contábil.&#x0D; Artigo 4 - Um estudo sobre os fatores determinantes da estrutura de capital das empresas brasileiras: uma análise de regressão quantílica de Osvaldo Martins Quintella Junior e Claudio Ulysses Ferreira Coelho com o objetivo de analisar os fatores determinantes da estrutura de capital de noventa e quatro empresas dentre as quinhentas maiores companhias brasileiras do anuário da revista Exame de 2018.&#x0D; Artigo 5 - Gerenciamento de resultados via accruals discricionários: seriam os lucros medidas confiáveis para os investidores? de Ronan Reis Marçal com o objetivo de analisar a relevância dos lucros na determinação do valor de mercado das empresas de capital aberto no Brasil considerando os efeitos do gerenciamento de resultado via accruals discricionários.&#x0D; Artigo 6 - Indicadores econômico-financeiros de empresas brasileiras: uma comparação entre setores de Vinícius Giovani Jacintho e Adriana Kroenke com o objetivo de analisar pesos de indicadores econômico-financeiros de diferentes setores da B3 e avaliar o impacto destes pesos ao se trabalhar com rankings de empresas de diversos setores simultaneamente.&#x0D; Artigo 7 - Características associadas ao nível de evidenciação das receitas de contratos com clientes das companhias de capital aberto brasileiras de Joice Aparecida Augusto e Maíra Melo de Souza com o objetivo de identificar características associadas com o nível de evidenciação das receitas de contratos com clientes nas companhias de capital aberto brasileiras.&#x0D; Artigo 8 - Value relevance: efeitos das especificidades contábeis das empresas brasileiras do segmento de construção civil e incorporação imobiliária de Paula Graciely da Silva Braga, Carlos Henrique Silva do Carmo e Moisés Ferreira da Cunha com o objetivo de analisar se a relevância da informação contábil, em relação ao valor de mercado, possui características diferentes nas empresas do segmento de construção civil e incorporação imobiliária em comparação com entidades dos demais segmentos.&#x0D; Artigo 9 - Aderência a teoria pecking order pelas firmas brasileiras: uma análise multisetorial de Thicia Stela Lima Sampaio, Alan Bandeira Pinheiro, Rubens Carlos Rodrigues e Eva Valéria Maia Lameu com o objetivo de analisar à luz da teoria pecking order a associação do endividamento total, de curto e de longo prazo, das empresas que negociam ações no Brasil Bolsa Balcão (B3), em seus diversos segmentos e exercício do compliance.&#x0D; Seção 2: Contabilidade Aplicada ao Setor Público e ao Terceiro Setor&#x0D; Artigo 1 - Análise da eficiência dos municípios sergipanos: comparação entre notas da prova Brasil e recursos destinados à educação de Nadielli Maria dos Santos Galvão com o objetivo o nível de eficiência dos municípios sergipanos em promover bons índices educacionais com os recursos destinados a este setor.&#x0D; Artigo 2 – A adequação dos grandes municípios brasileiros na divulgação das informações de margem de expansão das despesas conforme a LRF de Guilherme Simões Belote e Ricardo Rocha de Azevedo com o objetivo de verificar a adequação dos grandes municípios do Brasil na divulgação das informações no anexo da margem de expansão das despesas obrigatórias de caráter continuado (DOCC), previsto pela Lei de Responsabilidade Fiscal (LRF).&#x0D; Artigo 3 - Uma análise da eficiência dos gastos públicos com educação nos municípios do Estado do Amazonas no período de 2013 a 2017 de Mayara Guimarães de Sousa, Carla Macedo Velloso dos Santos, Adenes Teixeira Alves e Manoel Martins do Carmo Filho com o objetivo de avaliar a eficiência dos gastos públicos dos municípios do Estado do Amazonas com o ensino fundamental nos anos de 2013 a 2017 por meio da construção de um ranking da eficiência dos municípios relacionando os resultados obtidos no Ideb por cada município no período, sob a contrapartida dos valores das despesas liquidadas com educação fundamental, média de alunos matriculados no período, gasto médio por aluno e PIB per capita de cada município.&#x0D; Seção 3: Pesquisas de Campo sobre Contabilidade (Survey)&#x0D; Artigo 1 - Sistema de avaliação de desempenho para apoio à gestão da coordenadoria dos processos licitatórios de um Hospital Universitário de Samuel Souza de Araújo, Lucas dos Santos Matos e Sandra Rolim Ensslin com o objetivo de propor um modelo para apoiar a gestão da Coordenadoria de Processos Licitatórios do Hospital Universitário Professor Polydoro Ernani de São Thiago da Universidade Federal de Santa Catarina, visando construir, no seu gestor, conhecimento acerca do contexto ao qual administra, permitindo a visualização dos aspectos julgados como necessários e suficientes para se ter em consideração nesse processo.&#x0D; Artigo 2 - Balanced scorecard e a questão ambiental: um estudo sobre a percepção dos controllers de Maria do Rosário da Silva e Antônio André Cunha Callado com o objetivo de analisar a percepção dos controllers sobre o Balanced Scorecard e a questão ambiental e descrever o perfil destes profissionais.&#x0D; Artigo 3 - Enfrentando a cortina de fumaça: uma análise epistemológica sobre o uso da expressão “contabilidade criativa” de Roselaine Araújo Vassalo e Diana Vaz de Lima com o objetivo de analisar a percepção de estudantes e profissionais contábeis a respeito dos conceitos e usos dos termos associados à expressão “contabilidade criativa”.&#x0D; Artigo 4 – Institucionalização de regras e rotinas da contabilidade gerencial em uma fundação privada educacional catarinense: abordagem institucional do terceiro setor brasileiro de Renícia Maria Innocenti, Rogério João Lunkes e Valdirene Gasparetto com o objetivo de verificar a mudança de regras e rotinas da contabilidade gerencial de uma organização do terceiro setor à luz da Velha Economia Institucional (OIE).&#x0D; Artigo 5 - Expectativas e satisfação dos discentes sobre os saberes e competências requeridas dos docentes na área de ciências contábeis de Tamires Sousa Araújo, Edvalda Araújo Leal e Roberta Ferreira Lourenço com o objetivo de verificar na percepção dos estudantes de ciências contábeis quais as expectativas e satisfação em relação às competências dos docentes atuantes no curso, envolvendo a compreensão sobre conhecimentos, habilidades e atitudes.&#x0D; Artigo 6 - Traços de personalidade e variáveis do comportamento planejado do indivíduo: um estudo de seus efeitos nas intenções empreendedoras de Edicreia Andrade dos Santos, Gabriel Lourenço Xavier, Cristiane Alves da Silva Moura e Luiz Miguel Renda dos Santos com o objetivo de investigar quais os efeitos dos traços de personalidade sobre as intenções empreendedoras dos alunos concluintes dos cursos de Ciências Contábeis de duas instituições de ensino superior privadas e uma pública, localizadas na região centro-oeste do Brasil.&#x0D; Seção 4: Casos de Ensino Aplicados a Contabilidade&#x0D; Artigo 1 - Qual é o valor da empresa? O caso de valuation da empresa Magazine Luiza de Kelly Silva Jacques, Vivian Duarte Couto Fernandes, Lísia de Melo Queiroz e Moisés Ferreira da Cunha com os objetivos: a) promover a análise de problemas, propor e indagar decisões em relação à valuation; b) estimular a reflexão entre a teoria que sustenta os propósitos de avaliação e a forma como ela deve ser desenvolvida e aplicada; c) ampliar a capacidade de relacionar os pressupostos teóricos de valuation e a sua adequação à realidade.&#x0D; Artigo 2 - Planejamento orçamentário para a educação: superando um desafio de Jander Ângelo Diogo Ferreira, Naiany Gabrielle Pereira Lima, Juliana Saraiva Moreira, Odemir Vieira Baêta e Carla Beatriz Marques Rocha e Mucci. O caso de ensino foi preparado a partir de observações de questões vivenciadas pelo município de Cachoeiro de Santa Cruz e adaptadas para efeitos didáticos, com o objetivo de auxiliar na construção de um planejamento orçamentário governamental efetivo. Sua finalidade é fomentar a reflexão a respeito das limitações e potencialidades da gestão orçamentária municipal e, ainda, propor soluções aos fundos destinados à educação básica e fundamental, em cenários de restrição de ordem material e financeira.&#x0D; Seção 5: Resenhas de Teses, Dissertações e Livros sobre Contabilidade&#x0D; Resenha 1 - Resenha do livro: Fraudes documentais e contábeis. Timi, S. R. R. &amp; Heimoski, V. T. M. (2020). (1ª ed). Curitiba, PR: Editora Intersaberes, 194 páginas, ISBN: 978-8522702626&#x0D; Autora da resenha: Lorena Layza Pimenta Oliveira&#x0D; Seção 6: Banco de Dados (Arquivos suplementares em Excel)&#x0D; Artigo 1 da Seção 4 - Qual é o valor da empresa? O caso de valuation da empresa Magazine Luiza de Kelly Silva Jacques, Vivian Duarte Couto Fernandes, Lísia de Melo Queiroz e Moisés Ferreira da Cunha com os objetivos: a) promover a análise de problemas, propor e indagar decisões em relação à valuation; b) estimular a reflexão entre a teoria que sustenta os propósitos de avaliação e a forma como ela deve ser desenvolvida e aplicada; c) ampliar a capacidade de relacionar os pressupostos teóricos de valuation e a sua adequação à realidade.&#x0D; Artigo 2 da Seção 2 - A adequação dos grandes municípios brasileiros na divulgação das informações de margem de expansão das despesas conforme a LRF de Guilherme Simões Belote e Ricardo Rocha de Azevedo com o objetivo de verificar a adequação dos grandes municípios do Brasil na divulgação das informações no anexo da margem de expansão das despesas obrigatórias de caráter continuado (DOCC), previsto pela Lei de Responsabilidade Fiscal (LRF).&#x0D; Artigo 6 da Seção 1 - Indicadores econômico-financeiros de empresas brasileiras: uma comparação entre setores de Vinícius Giovani Jacintho e Adriana Kroenke com o objetivo de analisar pesos de indicadores econômico-financeiros de diferentes setores da B3 e avaliar o impacto destes pesos ao se trabalhar com rankings de empresas de diversos setores simultaneamente.&#x0D; Artigo 5 da Seção 1 - Gerenciamento de resultados via accruals discricionários: seriam os lucros medidas confiáveis para os investidores? de Ronan Reis Marçal com o objetivo de analisar a relevância dos lucros na determinação do valor de mercado das empresas de capital aberto no Brasil considerando os efeitos do gerenciamento de resultado via accruals discricionários.&#x0D; Seção 7: Internacional (S7)&#x0D; English&#x0D; Section 1&#x0D; Article 2 (Section 1) - The principles underlying the IFRS and the measurement bases of the elements comprising the financial statements of Camila Teresa Martucheli and Antônio Dias Pereira Filho. This theoretical essay seeks to present concepts, arguments and discussions about the adoption and use of IFRS, focusing on their underlying principles and measurement bases.&#x0D; Article 3 (Section 1) - Benefits of using Blockchain technology as an accounting auditing instrument of Maervelym Pâmella de Andrade Simões, Janeide Albuquerque Cavalcanti, Janaina Ferreira Marques de Melo and Cristiane Queiroz Reis. Analyze the possible benefits of using Blockchain technology as a tool for accounting auditing. &#x0D; Article 4 (Section 1) - A study about the determinant factors of the capital structure of Brazilian companies: a quantile regression analysis of Osvaldo Martins Quintella Junior e Claudio Ulysses Ferreira Coelho. The present paper aims to analyses the determinants of capital structure of ninety-four organizations from the five hundred largest Brazilian companies according to 2018 Exame magazine yearbook.&#x0D; Section 2&#x0D; Article 1 (Section 2) - Analysis of the efficiency of municipalities from the Brazilian State of Sergipe: a comparison of the results in Brazil’s evaluation of its basic education system and investments on education of Nadielli Maria dos Santos Galvão. To identify the efficiency of municipalities in the Brazilian State of Sergipe in promoting satisfactory education levels from the resources aimed at this sector.&#x0D; Article 3 (Section 2) - An analysis of the efficiency of public expenditure on education in the Municipalities of the State of Amazonas from 2013 to 2017 of Mayara Guimarães de Sousa, Carla Macedo Velloso dos Santos, Adenes Teixeira Alves and Manoel Martins do Carmo Filho. This article aimed to evaluate the efficiency of public expenditure in the municipalities of the State of Amazonas with primary education in the years 2013 to 2017 by building a ranking of the efficiency of the municipalities relating the results obtained in IDEB by each city in the period, under the counterpart of the values of expenses paid for primary education, the average number of students enrolled in the period, average expenditure per student and GDP per capita of each municipality.&#x0D; Section 3&#x0D; Article 1 (Section 3) - Performance evaluation system to support the Coordination of Bidding Processes management in a University Hospital of Samuel Souza de Araújo, Lucas dos Santos Matos and Sandra Rolim Ensslin. The purpose of this research is to structure a model to support the management of the Coordination of Bidding Processes at the Professor Polydoro Ernani de São Thiago University Hospital of Universidade Federal de Santa Catarina (Federal University of Santa Catarina). The main purpose is to build, in its manager, knowledge about the management context, allowing the visualization of the aspects deemed as necessary and sufficient to be taken into account in this process.&#x0D; Article 4 (Section 3) - Institutionalization of management accounting rules and routines in a private educational foundation in Santa Catarina: institutional approach of the Brazilian third sector of Renícia Maria Innocenti, Rogério João Lunkes e Valdirene Gasparetto. To verify the change of rules and routines of management accounting of a third sector organization in the light of the Old Institutional Economy (OIE).&#x0D; Article 6 (Section 3) - Personality traits and variables of the individual’s planned behavior: a study of its effects on entrepreneurial intentions of Edicreia Andrade dos Santos, Gabriel Lourenço Xavier, Cristiane Alves da Silva Moura and Luiz Miguel Renda dos Santos. This study aims to investigate the effects of personality traits on the entrepreneurial intentions of students concluding Accounting courses at two private higher education institutions and a public one, located in the Midwest region of Brazil.&#x0D; Section 4&#x0D; Article 1 (Section 4) - What is the value of the company? The valuation case of Magazine Luiza of Kelly Silva Jacques, Vivian Duarte Couto Fernandes, Lísia de Melo Queiroz and Moisés Ferreira da Cunha. Magazine Luiza, founded in November 1957, a national retail icon, started in 2011 at B3, with exponential growth in the valuation of its shares. This case provides the following pedagogical objectives: a) to promote the problem analysis, to propose and inquire decisions regarding valuation; b) stimulate reflection between the theory that supports the evaluation purposes and the way it should be developed and applied; c) expand the ability to relate the valuation theoretical assumptions of valuation and their adequacy to reality.&#x0D; Article 2 (Section 4) - Budget Planning for education: overcoming a challenge of Jander Ângelo Diogo Ferreira, Naiany Gabrielle Pereira Lima, Juliana Saraiva Moreira, Odemir Vieira Baêta and Carla Beatriz Marques Rocha e Mucci. This teaching case was prepared from observations of issues experienced by the municipality of Cachoeiro de Santa Cruz, and adapted for didactic purposes, with the objective of assisting in the construction of an effective government budget planning. Its purpose is to foster reflection on the limitations and potentialitys of municipal budget management and also to propose solutions to funds for basic and fundamental education, in scenarios of material and financial restrictions.&#x0D; Boa leitura. Cordiais saudações!&#x0D; Prof. Dr. Maurício Corrêa da Silva&#x0D; Editor Gerente da Revista Ambiente Contábil

Objective: A comparative analysis of hemoglobin (HB), mean corpuscular volume (MCV), and ferritin levels among pregnant women from all four provinces in Pakistan: Punjab, Sindh, Khyber Pakhtunkhwa, and Balochistan. Methods: It was a Cross-sectional Observational study. The study was conducted at four centers in Karachi, Quetta, Kharian and Mardan Pakistan for 1 year from 1St Feb 2022 to 31st Jan 2023. Maternal blood parameters were measured and compared across different regions of Pakistan to identify potential regional differences due to factors such as ethnicity, socio-economic status, and other factors. Results: The mean hemoglobin levels were 10.95 g/dL in Balochistan, 11.04 g/dL in KPK, 10.82 g/dL in Punjab, and 10.36 g/dL in Sindh. The mean MCV values was 80.56 FL in Balochistan, 79.70 FL in KPK, 77.94 FL in Punjab, and 80.89 FL in Sindh. The mean serum ferritin levels were 16.00 ng/mL in Balochistan, 23.84 ng/mL in KPK, 33.92 ng/mL in Punjab, and 20.93 ng/mL in Sindh. Conclusions: Overall, the results showed significant variation in the mean values for the different variables across the four provinces. We also noticed that gestational anemia is very common health issue all over Pakistan. This study provides valuable insights into regional differences in maternal blood parameters during pregnancy in Pakistan and may help in the development of regionally targeted interventions to address maternal anaemia. Keywords: Gestational Anaemia, Pregnancy, Iron Deficiency Anemia, Maternal Health

<strong>Original Research Paper</strong> <strong>Neurological Etiologies Necessitating Elective Tracheostomy in Pediatric Age Group: A 100 Patient Experience</strong> <strong>Authors:</strong> <strong>¹</strong><strong>Anju Benny, ²Muhammad Faraz Shamshad, ³Soumyadeep Sikdar, ⁴Shreshtha Singh, ⁵Amir Hassan, ⁶Yi Sin Leong, ⁷Areeba Siddiqui, ⁸Fazila Imtiaz,⁹ Hafsa Ashraf, ¹⁰Misha Anam</strong> <em>¹</em><em>ACS Medical College and Hospital(India)</em> <em>²</em><em>Karachi Medical &amp; Dental College, Karachi (Pakistan)</em> <em>³</em><em>Institute of Medical Sciences, Benaras Hindu University (India)</em> <em>⁴</em><em>Synergy Hospital, Dehradun, Uttarakhand (India)</em> <em>⁵</em><em>Rehamn Medical Institute (RMI), Peshawar (Pakistan)</em> <em>⁶</em><em>Universiti Kebangsaan Malaysia Medical Centre (Malaysia)</em> <em>⁷</em><em>Dow Medical College (Pakistan)</em> <em>⁸</em><em>Lahore Medical &amp; Dental College, Lahore (Pakistan)</em> <em>⁹</em><em>Shalamar Hospital, Lahore (Pakistan)</em> <em>¹⁰</em><em>Children Hospital &amp; The Institute of Child Health, Lahore (Pakistan)</em> Corresponding Author: Misha Anam, Children Hospital &amp; The Institute of Child Health, Lahore (Pakistan) <strong>Article Received:</strong>&nbsp; 10-08-2022&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <strong>Revised:</strong>&nbsp; 31-08-2022&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <strong>Accepted:</strong> 21-09-2022 <strong>ABSTRACT</strong><strong>:</strong> <strong>Background: </strong>Tracheostomy is a life-saving procedure and is indicated in a variety of peripheral or central conditions leading to respiratory compromise. Mainly, tracheostomy is done for three reasons; to bypass obstructed upper airway, to remove secretions and keep the airway patent; and to effectively ventilate the patient.<strong> Objective:</strong> The aim of this study is to quantify the frequency of different neurological disorders which indicate elective tracheostomy to avoid respiratory compromise and its associated complications.<strong> Materials and Methods:</strong> In this Prospective, observational study, 100 pediatric patients with confirmed neurological diagnosis and associated severe respiratory impairment requiring invasive mechanical ventilation were enrolled. The study was conducted over the period of 3 months, from May 2022 to July 2022, at Children Hospital and Institute of Child Health, Lahore.<strong> Results: </strong>According to the collected data, prevalence of male patients was almost twice as that of females (2.9:1). The main indication of tracheostomy was the requirement of prolonged mechanical ventilation due to neurological condition (n= 36, p&lt;0.02). Among all the neurological etiologies, the CNS infections with serious respiratory manifestations were most common including Guillain Barre Syndrome (n=26, p=&lt;0.01), Diphtheria Polyneuropathy (n=8, p=0.06), Hypoxic-Ischemic Encephalopathy (n=5, p&lt;0.08), Varicella Zoster Infection (n=3, p=0.09), Poliomyelitis / Post-Polio Syndrome (n=2, p&lt;0.1), and Tetanus (n=1, p=0.15).<strong> Conclusion: </strong>Infectious neurological diseases such as GBS, Diphtheria, and polio, causing respiratory failure are still prevalent in developing countries like Pakistan &amp; India and are the main causes of tracheostomy in pediatric age group. Prolonged mechanical ventilation was the main indication for tracheostomy. <strong><em>Keywords: tracheostomy, pediatrics, infections, GBS, ETT, neurological intensive care</em></strong> &nbsp; &nbsp; <strong>INTRODUCTION</strong><strong>:</strong> Tracheostomy is one of the ancient surgical procedures to bypass upper airway tract obstructions. About 40 years ago, pediatric tracheostomy was only indicated in the cases of infectious diseases of upper airway such as Diphtheria, Epiglottitis etc. [1]. Over the time, the indications and applications of tracheostomy were revised and evolved, considerably. With the administration of vaccines, the incidence of infectious diseases caused by <em>Cornybacterium Diphtheria</em> and <em>Hemophillus Influenzae</em> has decreased dramatically [2]. Hence, the number of pediatric emergency tracheostomies has fallen, globally. However, with the introduction of other indications of tracheostomy, the overall number of tracheostomies has increased over time [3]. Worldwide, the pediatric tracheostomy is performed in tertiary care facilities only, in children with acute or chronic, congenital, or acquired respiratory and/or neurological impairment, and in children with long term dependency on invasive mechanical ventilation [4]. There are a number of neurological etiologies that can result in severe respiratory impairments. Emergent Endotracheal Tube Placement with mechanical ventilation can save the patient temporarily but if the long term invasive mechanical ventilation is required, ETT must be replaced by tracheostomy [5]. According to the experts, if patient needs ETT and mechanical ventilation for 7 days or more, then tracheostomy should be performed for sustainable and secured airway [6]. Although in some cases of severe neurological impairment, patients need ETT assisted mechanical ventilation for a longer period of time, for example in case of a brain injury with poor GCS and unconsciousness, tracheostomy cannot protect the airway against secretions and gastric aspiration as ETT does [7]. Tracheostomy decreases the work required for breathing but that is not an issue for the patients with brain injury. Prolonged ETT intubation is associated with high risk of nosocomial pneumonia and prolonged ventilator dependency which can be significantly reduced by tracheostomy. Prolonged ETT intubation is also associated with a number of tracheal complications especially in the patients with severe brain trauma. If patient is intubated for more than 14 days, there is a high risk of development of serious complications such as laryngeal injury including laryngeal edema and inflammation, vocal cord injury, ulceration, paresis, paralysis, granuloma, and stenosis. So, it is important to weigh the pros and cons after regular and careful clinical evaluations of the patients [8]. There are a variety of neurological disorders which require tracheostomy as a part of an active or long-term management plan. These diseases/disorders include congenital/chromosomal/neurometabolic, idiopathic, traumatic, infective, autoimmune, and inflammatory disorders [9]. The incidence of infective neurological causes has decreased worldwide over the time, by the virtue of effective immunization. Nevertheless, these are still prevalent in developing countries due to poor vaccination coverage and healthcare provision. There are several neurological infections that cause acute flaccid paralysis and hence the respiratory compromise. The mechanism of respiratory disability may vary slightly, but the ones that are mentioned in the article required tracheostomy at some point in the management of the disease [9, 10]. Among all the acute neurological infections, Guillian Barre Syndrome (GBS) is the most common cause of peripheral, motor neuropathy with presumed antecedent infection and autoimmune etiology. Usually, the infection caused by <em>Campylobacter Jejuni</em> precedes the GBS with rapidly progressive axonal injury, ascending paralysis, respiratory failure, severe residual disability and slow recovery [11]. Globally, the incidence of GBS ranges from 1.1 to 1.8 per 100,000 people, annually [12]. The overall incidence of GBS increases with the age; peaks after 50 years. In Pakistan, the exact incidence and prevalence is not known. Electrophysiological studies for early detection, definitive diagnosis, and classification of GBS play an important role in significant reduction of morbidity and disability [13]. Poliomyelitis or Post Polio Syndrome is caused by highly infective, Enterovirus via feco-oral route [14]. It is a type of acute flaccid paralysis associated with prolonged or permanent flaccid muscle paralysis, respiratory failure, and death. Due to combined efforts, this sporadic, highly contagious infection is successfully eradicated from the world, except some areas of Sub-Saharan Africa and South Asia where it is still an endemic. In 95% of the infectious cases, the patients either remain asymptomatic or have a flu-like illness [15]. Despite effective preventive and management policies, some patients develop late functional complications after a long period of complete stability and recovery. This condition is called Post-Polio Syndrome. The bulbar form of Poliomyelitis involves high morbidity and mortality due to vasomotor, circulatory, and autonomic dysfunction along with respiratory failure. The acute respiratory failure needs emergent intubation and prolonged mechanical ventilation which can later indicate elective tracheostomy [16]. Diphtheritic Polyneuropathy (DP) is a serious bulbar, respiratory, and circulatory complication. It is a direct and acute indication for intubation and tracheostomy [17]. The etiology causes a decrease in lung&rsquo;s vital capacity (&lt;16mL/kg body weight), paralytic collapse of layrngeal muscles, and multiple cranial nerves impairment causing peripheral motor disturbances. Diphtheritic Polyneuropathy is also a late complication of diphtheria infection, so special attention should be given from the fourth to seventh week of DP [18]. The objective of this study is to determine the current neurological indications of tracheostomy in the pediatric age group and to assess the burden of infectious causes with central involvement in developing countries like Pakistan, despite the discovery and implementation of effective immunization all around the globe. <strong>MATERIAL &amp; METHODS</strong><strong>:</strong> In this prospective, observational study, 100 patients were recruited by following the inclusion and exclusion criteria. The study was conducted over the period of 3 months, from May 2022 to July 2022 at a tertiary care hospital. The Qualitative and Quantitative data was collected for 100 selected patients who were registered through the CH &amp; ICH, Lahore. Multi-departmental Collaboration was ensured. Verbally explained, written informed consent was taken from the guardians, mostly from the parents of the children. The whole purpose and procedure of this study was explained to the attendants. Few parents refused to take part in the study, their rights were respected, and they were not included in our study. By any means, this study does not adversely affect the rights and welfare of the subjects. All the patients had some neurological manifestation as a primary cause for elective tracheostomy. Those patients were also not included in the study which needed tracheostomy due to some other primary cause while the neurological condition co-existed. <strong>INCLUSION CRITERIA:</strong> Patients diagnosed with neurological impairments that were compromising the respiration by any means, i.e. Upper airway obstruction, Vocal cord paralysis/paresis, respiratory muscle paralysis/paresis, altered sensorium, skeletal/laryngeal muscle weakness, prolonged mechanical ventilation, etc. Patients who were on mechanical ventilation for &gt; 7 days Patients who required prolonged mechanical ventilation or on whom, ventilator weaning off attempts were performed but failed <strong>EXCLUSION CRITERIA:</strong> Patients of age more than 14 years Patients who needed tracheostomy for causes other than neurological anomaly Patients with incomplete previous medical record Patients with underlying diseases (other than neurological issues) such as hypothyroidism, diabetes, hepatic or renal dysfunction, vasculitis, metastasis, intoxication, etc. <strong>RESULTS</strong><strong>:</strong> According to the collected data, there were 67 males (p &lt;0.02) and 23 females (&lt;0.04) with male to female ratio of 2.9:1. The peak incidence of tracheostomy is seen at the ages of 2-5 years (n=29, p &lt;0.05) and 6-12 months (n=21, p&lt;0.05). P value less than 0.05 is considered significant. The demographic characteristics including age group and gender are described in Table 1. &nbsp; <strong>Demographic Characteristics</strong> <strong>Frequency (%age)</strong> <strong>P-value</strong> <strong>Age</strong> 0-6 months 16 (16%) Not Significant 6-12 months 21 (21%) &lt;0.05 1-2 years 11 (11%) Not Significant 2-5 years 29 (29%) &lt;0.05 5-10 years 10 (10%) Not Significant 10-14 years 13 (13%) Not Significant <strong>Gender</strong> Male 67 (67%) &lt;0.02 Female 23 (23%) &lt;0.04 <strong>Table 1 Demographic Characteristics of selected children (n=100)</strong> &nbsp; Eight different indications of elective tracheostomy in pediatric population were documented in this study. In descending order, the 3 main indications are prolonged invasive mechanical ventilation (n=36, p=&lt;0.02), Upper airway obstruction (n=20, p=&lt;0.04), and Metabolic/ Genetic/ Chromosomal anomalies (n=16. p=&lt;0.05). &nbsp; &nbsp; &nbsp; <strong>Indications of Tracheostomy</strong> <strong>Frequency (%age)</strong> <strong>P-value</strong> Upper Airway Obstruction 20 (20%) &lt;0.04 Prolonged Invasive Mechanical Ventilation 36 (36%) &lt;0.02 Hypoxic Brain Injury 8 (8%) Not Significant Metabolic / Genetic / Chromosomal 16 (16%) &lt;0.05 Cerebral Hemorrhage 4 (4%) Not Significant CNS Infection 9 (9%) Not Significant Demyelinating Disorder 5 (5%) Not Significant Brain Tumor 2 (2%) Not Significant <strong>Table 2 Indications of Elective Tracheostomy in children with neurological disease associated respiratory compromise</strong> &nbsp; Among the 100 selected patients, 16 different neurological conditions were documented, all leading to the respiratory failure by different mechanisms. Surprisingly, 45% of the total patients had neurological manifestation due to infectious etiology. The infectious causes of neurological conditions include (in descending order) Guillain Barre Syndrome (n=26, p=&lt;0.01), Diphtheria Polyneuropathy (n=8, p=0.06), Hypoxic-Ischemic Encephalopathy (n=5, p&lt;0.08), Varicella Zoster Infection (n=3, p=0.09), Poliomyelitis / Post-Polio Syndrome (n=2, p&lt;0.1), and Tetanus (n=1, p=0.15). &nbsp; <strong>Neurological Conditions</strong> <strong>Frequency (%age)</strong> <strong>P- value</strong> Poliomyelitis / Post-Polio Syndrome 2 (2%) Not Significant Guillain Barre Syndrome 26 (26%) &lt;0.01 Myasthenia Gravis 14 (14%) &lt;0.03 Diphtheria Polyneuropathy 8 (8%) Not Significant Varicella Zoster Infection 3 (3%) Not Significant Duchenne Muscular Dystrophy &nbsp;5 (5%) Not Significant Hypoxic-Ischemic Encephalopathy 5 (5%) Not Significant Cerebral Palsy 8 (8%) &lt;0.05 Spinal Muscular Atrophy (SMA) 3 (3%) Not Significant Neurofibromatosis 4 (4%) Not Significant Brain Tumors 6 (6%) Not Significant Kernicterus 5 (5%) Not Significant Leukodystrophy 2 (2%) Not Significant Amyotrophic Lateral Sclerosis 3 (3%) Not Significant Traumatic Brain Injury 5 (5%) Not Significant Tetanus 1 (1%) Not Significant <strong>Table 3 Spectrum and frequency of various neurological conditions necessitating elective tracheostomy</strong> &nbsp; During the period of 3 months of this study, no tracheostomy related mortality was documented. None of the patients underwent decannulation. The limitations of this study are that the duration of three months period did not allow the proper follow up of the patient and the prognosis, duration, and late complications of tracheostomy could not be assessed. <strong>DISCUSSION</strong><strong>:</strong> Tracheostomy is an operative procedure that creates a surgical opening on the anterior aspect of cervical trachea, mainly for effective ventilation [1, 2]. Patients with tracheostomy are a heterogeneous group of population with various indications and associated conditions. In this study, we only included the patients from pediatric age group requiring elective tracheostomy due to any congenital or acquired neurological condition [3, 4]. Children with congenital or acquired neurological disorders are prone to have respiratory co-morbidities [5]. There are multiple neurological manifestations that cause respiratory compromise such as pharyngeal/ laryngeal muscle weakness leading to Vocal cords dysfunction, respiratory muscle weakness or paralysis causing hypoventilation, skeletal muscle weakness i.e. SMA associated with prolonged immobility, pooling of respiratory secretions in respiratory tract, recurrent lung infections, and irreversible destruction of lung parenchyma [6, 7]. In patients with Cerebral Palsy and other neuromuscular disorders, pharyngeal and laryngeal muscles fail to maintain the patency of upper airway tract against inspiratory negative pressure [8, 9]. The hypotonic pharynx tends to remain collapsed causing upper airway narrowing or obstruction. Whenever, the patient develops acute upper or lower respiratory tract infection, the condition worsens with additional mucosal swelling and pooling of respiratory secretions due to ineffective clearing of sputum [10]. Moreover, the muscular weakness also results in disrupted swallowing mechanism causing GERD (Gastro-Esophageal Reflux Disease) and micro aspirations due to prolonged immobility and loss of protective cough reflex. All these factors make the patient prone to develop permanent lung damage via recurrent bronchitis, bronchiectasis, and pneumonia [11]. Tracheostomy has several therapeutic as well as palliative applications in patients with neurological diseases. As discussed in this article, tracheostomy provides secure and sustainable pathway for short or long-term invasive mechanical ventilation. It secures the breathing pathway in case of upper respiratory tract obstruction. It reduces the physiological dead space and significantly reduces the work required for breathing [12]. It provides effective, less traumatic and easily accessible route for airway toileting via sputum suctioning which is essential, especially during acute respiratory tract infections. In the case of emergency positive pressure ventilation, tracheostomy provides a quick, accessible route and significantly decreases the morbidity and mortality caused by delayed or unsuccessful attempts of endotracheal tube placement. Although noninvasive ventilation is an alternative emergency maneuver, but in the patients with neurological diseases, the invasive ventilation is preferred due to the high risks of secretions and gastric content aspiration. It also provides a safe route for diagnostic as well as therapeutic endoscopy, reduces the duration of procedure, and significantly minimizes the procedure associated risks [13, 14]. In most of the conditions, early tracheostomy proves to be highly beneficial in terms of decreasing morbidity and disability [23]. For example, in GBS, early tracheostomy can end the dependency on mechanical ventilator, providing more comfort and a chance of commencement of early oral nutrition with adequate oral hygiene that can speed up the weaning process [24]. It also adds to the parent&rsquo;s satisfaction and patient&rsquo;s motivation for the quick recovery. But the decision of tracheostomy is often critical, and it needs expert&rsquo;s opinion and evaluation to assess the pros and cons of tracheostomy. In the neurological cases where there is an increased risk of aspiration, ETT intubation with inflated cuff provides more protection and safer airway. However, ETT is not a sustainable way to maintain airway and is associated with various early and late complications [25-27]. In the literature, the indications of tracheostomy are not found consistent throughout the world. In developed countries, tracheostomy is mainly indicated in traumatic, chromosomal, autoimmune, or inflammatory conditions [15-18]. Whereas, in developing countries, the major causes requiring tracheostomy are infections and their peripheral and central ramifications. In Pakistan, the vaccination rate in children is considerably lower than that of developing countries due to ineffective surveillance and lack of general public awareness [19, 20]. However, the unvaccinated or partially vaccinated are not the only ones susceptible to infectious diseases. The severe neurological infectious diseases such as GBS, Diphtheria etc., are also found common in fully immunized children. In that case, there are multiple reasons to consider, but the experts speculate that the main reason for this poor coverage is low quality vaccination. In developing countries like Pakistan, less immunogenic vaccinations are prevalent because of limited resources and cost effectiveness [21, 22] <strong>CONCLUSION</strong> This study demonstrates the frequency of different neurological conditions with significant respiratory complications that necessitate surgical tracheostomy. All over the world, the infectious causes of tracheostomy have almost diminished but these are still prevalent in our setup. According to this study, prolonged mechanical ventilation was the most common indication and GBS was the most common neurological condition requiring elective tracheostomy for better prognosis in children. <strong>REFERENCES</strong><strong>:</strong> Monteiro S, Farias TP, Camargo Millen MD, Locio RV. The History of Tracheostomy. InTracheostomy 2018 (pp. 1-9). Springer, Cham. Noorulla KA, Kumar MK, Talat M, Rajesh P. EVALUATION OF THE INDICATIONS AND OUTCOMES OF TRACHEOSTOMY DONE IN ICU: A CLINICO-OBSERVATION STUDY. 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This work presents the design and construction of a laryngoscope model with camera vision that has a vibrating device to alert the medical specialist when the force exerted causes possible damage to the patient's airway during the intubation process. Design and fabrication considerations are described using Cast Material Position (FFD). The design is validated with the use of a high-fidelity simulator, the performance is compared with commercial models and the criteria of specialists are taken into account to improve all the necessary aspects. The model presented a great functional advantage, providing greater patient safety, reducing the risk of exposure of the internal tissue to high forces in the intubation process, facilitating clinical processes for health personnel.&#x0D; Keywords: Video laryngoscope, intubation, 3d printer, PLA.&#x0D; References&#x0D; [1]D, Freitas. “Prototipo De Videolaringoscopio: Wi-Mac-Multivision”. Revista Chilena De Anestesia. Volumen (49), número (2), páginas (262-270), 2020.&#x0D; [2]G, Velázquez. “Videolaringoscopio Artesanal Macintosh”. Anestesia en México. Volumen (28). Número (1). Abril 2016.&#x0D; [3]R, Cooper. J, Pacey. M, Bishop. S, McCluskey. “Early clinical experience with a new videolaryngoscope (GlideScope) in 728 patients”. Can J Anaesth. Volumen (52), número (2), Feb 2005.&#x0D; [4]C, Billington. P, Kearns. R, Kirkbride. K, Mackintosh. C, Reeve. et al. “A comparison of McGrath and Macintosh laryngoscopes in novice users: a manikin study”. Anaesthesia. Volumen (64), número (11), Nov 2021.&#x0D; [5]A, Jungbauer. M, Schumann. V, Brunkhorst. A, Börgers, H, Groeben. “Expected difficult tracheal intubation: a prospective comparison of direct laryngoscopy and video laryngoscopy in 200 patients”. Br J Anaesth. Volume (102), number (4), April 2009.&#x0D; [6] A, Caño. M, De la Cruz. “Diseño, ingeniería, fabricación y ejecución asistidos por ordenador en la construcción: evolución y desafíos a futuro”, Informes de la Construcción. Volume (59), number 505, pag 53-71, marzo 2007.&#x0D; [7]V, Mazzanti. L, Malagutti. F, Mollica. “FDM 3D Printing of Polymers Containing Natural Fillers: A Review of their Mechanical Properties”. Polymers. 28 jun 2021.&#x0D; [8]K, Howard. Y, Huang. R, Matevosian. M, Kaplan. R, Steadman. “Video-assisted instruction improves the success rate for tracheal intubation by novices”. Br J Anaesthesia. Volume (101), number(4):568–572. Oct 2008.&#x0D; [9]S, Maya. “Role of video laryngoscopes in anesthesia practice”. Revista Mexicana de Anestesiología. Volume (35). Number (1), 344-361, Jun 2012.&#x0D; [10]M, Kaplan. D, Ward. G, Berci. “A new video laryngoscope-an aid to intubation and teaching”. J Clin Anesth. Volume (14), number (8), 620-626. Dec 2002.&#x0D; [11]D, Cabrera. G, Massano. S, Fernandez. S, Chaile. et al. “Video-laringoscopio de bajo costo desarrollado con tecnología de impresión 3D”, Revista Chilena de Anestesia, volumen (47), numero 4, 2018.&#x0D; [12]N, Perez. A, Sanchez. M, Guagliano. M, Villanueva. “HISOPOS, LARINGOSCOPIOS Y AEROSOL BOX-IMPRESIÓN 3D COVID-19”, Ministerio de Ciencia, Tecnología e Innovación-Argentina. 2020.&#x0D; [13]K, Yoontae. E, Lee. A,Davydov. S, Frukhbeyen. J. Seppala. S, Takagi. L, Chow and S, Alimperti. 3Dprint.com, “Biofabrication of 3D printed hydroxyapatite composite scaffolds for bone regeneration”. 30 nov 2020.

Abstract Background 85% of Americans own a smartphone and there were 230 billion downloads in 2021. 1,2 American diabetic patients have been reported to have limited health literacy. 3 55% of Americans do not graduate from high school. 4 African American, Hispanic patients and Asian patients comprise 20%, 22% and 19% of diabetic patients, respectively, but a greater proportion of hospitalization rates. 5 Many of these patients and their families use mobile apps for health questions. The accessibility of eHealth apps is changing how patients access health information. Purpose To evaluate free diabetes health apps as an intervention to reduce health disparities in our diabetic patients. Methods Using search term, "diabetes" in GooglePlayStore(Android/AD) and AppleAppStore(iOS) to find the best, free diabetes apps. Exclusion criteria: less than 100,000 downloads (DL) on Google and&amp;lt;1600 reviews (RE) on Apple (Apple does not provide download data). The app introduction was "pasted" into readabilityformulas.com and webfx.com for analysis via Flesch-Kincaid Reading Ease (FRE), Flesch-Kincaid Grade Level Score (FGL), Simple Measure of Gobbledygook Index (SI), and the Dale-Chall Adjusted Grade Level (DCGL). Results AD(DL): 1-mySugr(1M),2-OnetouchReveal(1M),3-DiabetesBloodSugar(1M),4-BloodGlucoseTracker(500K),5-Diabetes(500K),6-Health2Sync(500K),7-DiabetesM(500K), 8-GlucoseBuddy(500K), 9-BeatDiabetes(100K), 10- Contour Diabetes App (100K);iOS(RE): 1-OnetouchReveal(87K), 2-GlucoseBuddyDiabetesTracker(21K), 3-Onedrop(20K), 4-GlucoseBloodSugarTracker(17K), 5-Livongo(13K), 6-mySugr(9.6K), 7-Sugarmate(9.4K),8-Klinio(3K), 9- Glycemic Index Load Net Carbs (2.2K), 10- Diabetes Logs (1.6K). Push notification=19/20 apps(AD=9, iOS=10). Connect users to GoodRx=0/20 apps. Connect users to professional care team/diabetes education=8/20 apps(AD=3, iOS=5). Connect users to free/discounted insulin/health products=0/20 apps. Spanish=11/20, Chinese=5/20 apps (AD=3, iOS=8, some apps have both). Only 2/20 apps were at 7-8th grade and the rest were high school and beyond. Free test strips were offered only on 1/20 apps(Livongo). Conclusion Free diabetes apps are helpful and may serve as an easily accessible educational tool for our patients. The physician can play a role in navigating the eHealth space with the patient. References: Perez S. App stores saw record 218 billion downloads in 2020, consumer spend of $143 billion, TechCrunch.com. Posted 13 Jan 2021. https://techcrunch.com/2021/01/13/app-stores-saw-record-218-billion-downloads-in-2020-consumer-spend-of-143-billion/?guccounter=1&amp;guce_referrer=aHR0cHM6Ly93d3cuZ29vZ2xlLmNvbS8&amp;guce_referrer_sig=AQAAABDcJH4OHOqQiUHWuJW-KMA566Z-7bAE2FfaumvCMoPgE5oC0RoRUDiVnpqdDbe4aYSrlv2Uc-FHkQkx19emxvqXb9Q_ldDGOcYelOSGaj4bldElJyxUIIBaEe5y1vCwJcCagPCmKWjNbMsNhnij34mmepSYbbEqDW0p7BnGlpBk"&amp;gt;https://techcrunch.com/2021/01/13/app-stores-saw-record-218-billion-downloads-in-2020-consumer-spend-of-143-billion/?guccounter=1&amp;guce_referrer=aHR0cHM6Ly93d3cuZ29vZ2xlLmNvbS8&amp;guce_referrer_sig=AQAAABDcJH4OHOqQiUHWuJW-KMA566Z-7bAE2FfaumvCMoPgE5oC0RoRUDiVnpqdDbe4aYSrlv2Uc-FHkQkx19emxvqXb9Q_ldDGOcYelOSGaj4bldElJyxUIIBaEe5y1vCwJcCagPCmKWjNbMsNhnij34mmepSYbbEqDW0p7BnGlpBk Accessed 17 Jan 2022. Ceci L. Annual number of mobile app downloads worldwide 2021. Statista.com. Posted 14 Jan 2022. https://www.statista.com/statistics/271644/worldwide-free-and-paid-mobile-app-store-downloads/ Accessed 17 Jan 2022. Abdullah A, Lieu SM, Salim H et al. Prevalence of Limited Health Literacy Among Patients with Type 2 Diabetes Mellitus: A Systematic Review. PLoS One. 2019;17(1): e0261430. National Center for Education Statistics. https://nces.ed.gov/naal/kf_demographics.asp. Accessed 20 Jan 2022 Cheng YJ et al. Prevalence of Diabetes by Race and Ethnicity in the United States, 2011-2016. JAMA. 2019;322(24): 2389-2398. doi: 10.1001/jama.2019.19365. Accessed 19 Jan 2022. Presentation: No date and time listed

Background:Osteoarthritis (OA) is the commonest disease affecting hip joints and has high prevalence across various age groups [1,2]. Effusion is a hallmark of OA and could represent a potential target for therapy [3–5]. Positive correlations of effusion to clinical outcomes are not well established, partly due to variability in manual assessment. Voxel-based volume quantification could reduce this variability [6].Objectives:We examine the inter-observer agreement of manual assessment of voxel-based effusion volume from coronal STIR MRI sequences at two time points and examine the feasibility of using Artificial Intelligence (AI) for standalone volume assessment.Methods:Our algorithm is based on Mask R-CNN [7] and was trained on labeled effusion regions in MRI slices from 68 patients with hip osteoarthritis. For validation, 2 human readers measured effusion from MRI STIR sequences of 25 patients at baseline and at 8 weeks follow-up. AI was used to measure effusion volume as an independent reader. Agreement between human readers and AI was assessed using absolute difference in volume (DV), Coefficients of Variation (CoV) and intraclass correlation coefficient (ICC).Results:Effusion regions detected by AI closely correlated with manual segmentation (Figure 1) for all samples. Differences in volumes measured by each pair of readers are summarized in Table 1. Agreement was excellent between human readers (ICC=0.99) and for each reader vs AI (ICC = 0.85-0.87).Figure 1.Mask overlays of regions of joint fluid detected by human readers (green, column 2) and AI (red, column 3) from 3 different patients. Raw MRI images are shown in column 1.Table 1.Comparison of volumes measured in cubic millimeters and agreement between each pair of readers (with AI as the 3rd reader)Volumes measured by readersAgreement between reader pairsReaderOverall VolumeMean ± Standard DeviationReader PairDifference in VolumeMean ± Standard DeviationCoVICCReader 16943 ± 5845Reader 1-21127 ± 9000.210.99 [0.98, 1.0]Reader 27638 ± 5619Reader 1-AI3311 ±16430.350.87 [0.7, 0.94]AI11014 ± 4454Reader 2-AI4151 ± 49860.270.85 [0.66,0.94]Conclusion:Initial results of automatic effusion measurement using AI show high agreement with human experts. This has potential to reduce variability and save expert time in OA MRI assessment, and to lead to improved OA care.References:[1]Sharif B, Garner R, Hennessy D, Sanmartin C, Flanagan WM, Marshall DA. Productivity costs of work loss associated with osteoarthritis in Canada from 2010 to 2031. Osteoarthritis Cartilage. 2017 Feb;25(2):249–58.[2]Sharif B, Kopec J, Bansback N, Rahman MM, Flanagan WM, Wong H, et al. Projecting the direct cost burden of osteoarthritis in Canada using a microsimulation model. Osteoarthritis Cartilage. 2015 Oct;23(10):1654–63.[3]Loeuille D, Chary-Valckenaere I, Champigneulle J, Rat A-C, Toussaint F, Pinzano-Watrin A, et al. Macroscopic and microscopic features of synovial membrane inflammation in the osteoarthritic knee: correlating magnetic resonance imaging findings with disease severity. Arthritis Rheum. 2005 Nov;52(11):3492–501.[4]Fernandez-Madrid F, Karvonen RL, Teitge RA, Miller PR, An T, Negendank WG. Synovial thickening detected by MR imaging in osteoarthritis of the knee confirmed by biopsy as synovitis. Magn Reson Imaging. 1995;13(2):177–83.[5]Atukorala I, Kwoh CK, Guermazi A, Roemer FW, Boudreau RM, Hannon MJ, et al. Synovitis in knee osteoarthritis: a precursor of disease? Ann Rheum Dis. 2016 Feb;75(2):390–5.[6]Quinn-Laurin V, Thejeel B, Chauvin NA, Brandon TG, Weiss PF, Jaremko JL. Normal hip joint fluid volumes in healthy children of different ages, based on MRI volumetric quantitative measurement. Pediatr Radiol. 2020 Oct;50(11):1587–93.[7]He K, Gkioxari G, Dollár P, Girshick R. Mask r-cnn. In: Proceedings of the IEEE international conference on computer vision. openaccess.thecvf.com; 2017. p. 2961–9.Acknowledgements:Jacob Jaremko is supported by the AHS Chair in Diagnostic Imaging at the University of Alberta. Medical Imaging Consultants (MIC) funds musculoskeletal radiology fellowships for Vanessa Quinn-Laurin at the University of Alberta, and provides Jacob Jaremko and Robert Lambert with protected academic time. Banafshe Felfeliyan is supported by an Alberta Innovates Graduate Student Scholarship for Data-Enabled Innovation.Disclosure of Interests:None declared.

Background: Coronavirus disease 2019 is a newly emerged viral infection reported in India on 30th Jan 2020. Because of high transmissibility rate it spread rapidly and become a pandemic in the year 2020. Though it was a new disease, there were no specific treatment measures for the same. COVISHIELD is the vaccine manufactured from serum institute of India and give approval for emergency use from 30th Dec 2020 without conducting phase trials, Because of numerous infective cases, complications and deaths. There is no separate AEFI surveillance system for COVID 19 vaccines. All the AEFIs were reported via immunization division of Ministry of Health and Family welfare. Objective: 1. To identify the type of AEFI following COVID 19 vaccination. 2. To detail the outcome of AEFI following COVID 19 vaccination Methodology: An observational study on AEFI following COVID 19 vaccination in India, the secondary data during 2020 to 2022 was collected from the open access government data http://surl.li/npkmb from 1st to 20th Oct 2023. The causality assessment results, 254 reported serious AEFI cases were approved by National AEFI Committee on 3rd May 2022.2 The data analysed by using SPSS Statistics. Results: A total of 125 million COVID 19 vaccine doses were administered all over India till 2nd Feb 2022. Out of which 254 reported serious AEFI. Among this 20.1% were =60 years of age. Serious AEFI with hospitalization was 57.9% and death was 42.1%. Around 30.7% cases were found to have a consistent causal association to vaccination. Among this 60.26 %were anxiety related and 39.74 % were vaccine product related. 8 deaths per 1 lakh COVID 19 vaccinations. Only 24.4% of the people with severe AEFI have comorbidities. Conclusion: Benefits of COVID 19 vaccination are enormous. However, as a measure of utmost precaution, all emerging AEFI are being constantly tracked and reviewed periodically.

Abstract Background MRIs of the brain in patients with short stature have shown a number of abnormalities. Some of these radiological findings can have clinical significance. Here we have looked at MRI results in such a population. Objective To review the value and significance of the prevalence of all abnormal MRI findings of children with short stature who are to undergo growth hormone therapy (GHT). Materials and methods This study involved a retrospective review of MRI findings in all children prescribed GHT within a pediatric health network's database from Jan 2020 to Aug 2021. Post-gadolinium contrast enhanced brain and pituitary MRIs utilizing 2 mm slices were used to calculate pituitary volume. Pituitary volume was calculated using the ellipsoid formula (LxWxH/2). Pediatric patients diagnosed with non-acquired GHD or ISS, with MRIs having been performed between Jan 2020 and Aug 2021 and having been prescribed GHT by Aug 2021 were included in this study. Patients who experienced other endocrine abnormalities such as SGA, Turner Syndrome, and Noonan Syndrome were excluded. Patients with obstruction of sellar and parasellar religion due to movement artifacts or magnetic interference on their MRIs were also excluded. Results Of one hundred and twelve patients found, eighty one met criteria for inclusion in this study. Of the eighty one MRIs reviewed, twenty eight children, 34.6%, had normal pituitary anatomy and fifty three, 65.4%, had a pituitary abnormality. Out of the fifty three with a pituitary abnormality, forty three subjects, 81.1%, were determined to have a small pituitary volume, including significant pituitary hypoplasia. Ten subjects (18.9%) had an enlarged pituitary volume (pituitary hyperplasia). Of these ten patients who had an enlarged pituitary volume, eight were pubertal (80%). Nine children with a pituitary abnormality (16.9%) had additional structural anomalies on their MRIs. One had a small left frontal developmental venous anomaly. Two had Rathke's cleft cysts. Two had pars intermedia cysts. One had a small right parietal developmental venous anomaly. One had a small left parietal developmental venous anomaly. One had a left cerebellar tonsillar ectopia bordering on chiari malformation (.5 mm away on the coronal plane). One had a small lobulation (semi-bulbous projection) of the anterior pituitary gland, superior and anterior to the infundibular stalk. Conclusion Prevalence of brain abnormalities in children with short stature who are to undergo GHT is significant and warrants MRI evaluations in these subjects. Presentation: Saturday, June 11, 2022 1:00 p.m. - 3:00 p.m., Monday, June 13, 2022 12:58 p.m. - 1:03 p.m.

e13613 Background: Prior to COVID-19, there were few telehealth services offered in the oncology specialty area. During the pandemic, we at a national cancer center rapidly scaled our oncology telehealth program to meet the needs of our patients. At the peak of the pandemic, telehealth initially served as a risk-mitigation strategy providing continued care to our patients while socially distancing, yet additionally, we have embedded necessary processes in place to create a sustained a telehealth oncology program that encompasses a hybrid model including face to face visits augmented with telehealth visits, where appropriate. Here we describe the key telehealth program features that have enabled a national cancer center to evolve into a hybrid model of oncology care across its five geographically distinct hospitals. Methods: Transitioning into a sustainable hybrid telehealth model of care involves a foundation of clinical leadership and partnerships among multiple departments. The telehealth oncology program leaders collaborate with the operations, technology, finance, clinical care teams, and governance council to implement telehealth growth initiatives and nimbly troubleshoot and ameliorate issues. A concierge service provides telehealth readiness checks to ensure timely resolution of issues. Workflows are followed to standardize processes. Telehealth use-cases ensure patients who need on-site services keep their in-person appointments, allowing telehealth visits for symptom management to enhance patient outcomes. A provider education session includes training on telehealth technology and “webside manner” training to ensure we preserve the personal touch with our patients in each telehealth encounter. Program data is regularly collected and reviewed to track the program’s success and opportunities for improvement. Results: After the initial peak of telehealth visits driven by the COVID pandemic, we continue to see a sustained 10-fold increase in service volume versus Jan/Feb 2020. There were 25,328 total telehealth visits from Mar. 2020-Jan. 2021, 75 clinical trial visits between July-Dec. 2020, and 848 readiness check escalations from Nov. 2020-Dec. 2021. Service lines expanded from 2 to 33, including growing rural health partnerships and a home chemotherapy infusion model. Use-cases expanded to bridge to on-site care, rapid initial visits, preop/postop checks, symptom management, and surveillance. Press Ganey patient satisfaction rates are as high as 92% and 90% of providers reported overall satisfaction with the telehealth consultations. Conclusions: Our key program features have enabled the growth and success of our enterprise tele-oncology program. One of the most promising indicators of success is the positive provider and patient satisfaction rates. Telehealth provides an effective means to provide a bridge to onsite cancer care even for our complex oncology patients.

Abstract In Colombia, approximately 17,000 new cases are diagnosed each year with an incidence of 50 cases/100 hab/year [1]. Access to screening [2], integration of curative with adjuvant therapies [3-6], and new systemic treatments [7,8,9] in ABC have been shown to improve survival outcomes. However, the impact on long-term overall survival has not been reported in the Colombian population. Methods: Pts with BC, complete relevant clinical information and long term follow up between January 2013 to December 2023 at The Comprehensive Cancer Center Clinica de Occidente in Cali-Colombia, were retrospectively identified. We collected relevant variables from electronic medical records. Our primary objective was to determine the 10 years OS by stage and important clinical variables. We performed Kaplan Meier, and cox regression analysis. The study was approved by the institutional ethics committee. Results: We identified 831pts with complete clinical information and adequate follow-up. Demographic characteristics are described in table 1. De novo metastatic disease was found in 10% of pts. This was higher when health insurance was exclusively subsidized by the state (15%) vs. mixed insurance (9%) (private + public), OR 1.7 (95% CI 1.0-2.9), P=0.01. Table 2 and Figure 1 describes the 10y OS by stage, with 88% in stage I vs. 23% in stage IV. Multivariate analysis showed that density of lymph node involvement, metastasis at diagnosis, poor PS, and advanced age were significantly associated with increased risk of death. However, living in rural areas or small cities, type of health insurance, history of DM2, hypertension, smoking, family history of breast cancer, or HER2-positive subtype did not significantly affect survival. The 10y OS was 62% in non-Luminal A subtypes (figure 2), 44% in T4 tumors, 41% in patients with Age380y, 32% in N3 lymph node involvement and only 5% in patients with PS ECOG32 (figure 3). Conclusions: We report the longest follow up for overall survival in a cohort of pts with BC from an comprehensive cancer center in Colombia and confirm that the prognosis in survival has improved, especially for luminal tumors, but it is still poor if it is detected late in a locally advanced or metastatic stage (approximately 27% of all cases) or with deteriorated functional status. Therefore, increasing early detection and the inclusion of new systemic therapies are necessary to improve the probability of survival in higher-risk subgroups. References 1. Ferlay J, et al (2024).Global Cancer Observatory. Available from: https://gco.iarc.who.int/today, accessed [06 Jul 2024] 2. Monticciolo DL, et al. Radiology. 2024 Feb;310(2):e232658. 3. EBCTCG. Lancet. 2023 Apr 15;401(10384):1277-1292. 4. EBCTCG. Lancet Oncol. 2021 Aug;22(8):1139-1150. 5. EBCTCG. Lancet. 2015 Oct 3;386(10001):1341-1352. 6. EBCTCG. Lancet. 2011 Nov 12;378(9804):1707-16. 7. Hurvitz SA, et al. Lancet. 2023 Jan 14;401(10371):105-117. 8. Hortobagyi GN, et al. N Engl J Med. 2022 Mar 10;386(10):942-950. 9. Cortes J, et al. N Engl J Med. 2022 Jul 21;387(3):217-226. Citation Format: Ana Fidalgo, Milton Alberto Lombana Quiñonez, Guido Ricardo Gonzales Fontal, Sergio Cafiero Ballesteros, Juan Carlos Avila Valencia. 10y overall survival (OS) in patients (pts) with breast cancer (BC) at a comprehensive cancer center in Colombia [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2024; 2024 Dec 10-13; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2025;31(12 Suppl):Abstract nr P3-10-07.

e13640 Background: Sharing findings of clinical trials using the internet and social media is increasing. Altmetric attention scores are instantaneous evaluations of the influence and popularity of science in a variety of media, such as news, blogs, and different social media platforms. Altmetrics’ distributions and trends for subgroup analyses were not previously investigated. Our study aimed to characterize altmetrics of the studies reporting subgroup analyses of breast cancer clinical trials and to assess the association between altmetrics and other characteristics of publications. Methods: We performed a systematic review of all published secondary analyses of breast cancer clinical trials form Jan 2020 until Feb 15, 2022. 1491 secondary analysis of solid malignancies were identified of which 287 were related to breast cancer. The altmetric scores for the included studies were obtained from a website named Bookmarklet for Researchers on the 12th of Feb 2023. Pearson’s correlation, Independent Samples t test, the one-way analysis of variance (ANOVA), and Chi-Square test were utilized to identify associations between a number of the studies’ characteristics and altmetrics. Statistical analysis was completed using SPSS Statistics. Results: Altmetric scores were captured for 211 (73.5%) of the 287 included publications. The median score was 4 (IQR 2-19). The captured altmetric scores ranged from 1 to 882. Around 45% of the included studies were first-authored by women and pharmaceutical companies funded approximately 35%. Both gender and funding source did not show any effect on the altmetric scores. Higher altmetric scores ( &gt; = 4) were associated with authors who reported conflicts of interest (COI) (P = 0.001), studies published in 2015 or after (P = 0.003), papers published in journals with higher impact factors (P &lt; 0.001), and publications with a higher number of authors (P = 0.019). Conclusions: Higher number of authors, presence of COI, higher impact factor of the publishing journal, and a publication year of 2015 or after are associated with higher altmetric scores in subgroup analyses of breast cancer-based clinical trials. Given the observational nature of secondary analysis and possible inaccurate conclusions, caution must be entertained when interpreting their findings.

Retraction NoticeManuscript Title: A Statistical Study to Compare the Practical and Theoretical Values of Yield of Activated Carbon Prepared from Pomegranate PeelsAuthor Name: Semaa I. Khaleel, Emad A.S.AL-Hyali, , Ammar A.H.AL-KhazrajiJournal Title: International Journal of Recent Research in Physics and Chemical Sciences (IJRRPCS)Other details: Vol. 10, Issue 2, pp: (71-82), Month: October 2023 &ndash; March 2024Reason for retraction: On author's requestDate of retraction: 12 Feb 2024

Abstract Background Variability in real-world (RW) study designs is often seen as a limitation for drawing conclusions. With more RW studies assessing effectiveness and safety of advanced therapies (ATs) in patients (pts) with moderate to severe UC, there is a need to better understand the study characteristics, clinical characteristics, treatments (Tx), and outcomes. Methods We conducted a SLR as per methodology described by Cochrane Collaboration and PRISMA guidelines, using Embase®, MEDLINE®, and MEDLINE®-In Process databases to find RW studies assessing biologics [bio] (adalimumab, golimumab, infliximab, vedolizumab/VEDO, and ustekinumab) or small molecules (filgotinib/FIL, ozanimod/OZA, and tofacitinib/TOFA) for adults with UC. Only products approved at the time of search were included. Studies published in English as full papers (Jan-2005–Feb-2022)or conference abstracts (Jan-2019–Feb-2022) were included. Studies with &amp;lt;30 pts or with only bio-naïve pts were excluded. Results From 3930 search results, 139 studies were included. Of these, 75% were published between 2019–2022; 64% were retrospective observational; and 53% were from 5 countries (Italy, US, Spain, UK, and Belgium). The median age of pts across studies was 26–55 years and male proportion ranged 25%–73% (Fig 1). 13% of studies had only bio-exposed pts, 63% had &amp;gt;50% pts bio-exposed and 28% presented sub-analysis for bio-exposed pts. Most studies (87%) were single arm; VEDO (41%) was the most evaluated Tx, followed by TOFA (20%). No studies were found for FIL or OZA. Clinical remission (CR; 69%), clinical response (69%), and steroid-free CR (46%) were commonly reported outcomes, whereas histologic (6%) and sustained remission (4%), and patient-reported outcomes (PROs; 5%) were uncommon (Fig 2). In studies reporting CR, Partial Mayo Score (PMS) or Full Mayo Score ≤2 alone or combined with rectal bleeding and stool frequency subscore ≤1 were commonly used definitions, followed by PMS ≤1 and Simple Colitis Clinical Activity Index ≤2. Most studies assessed outcomes within 52 weeks (76%). Any adverse event (AE; 46%), colectomy (46%), withdrawal due to AE (37%), and infections (24%) were frequently reported safety events. Only up to 12% of studies reported data on MACE, malignancies and VTE. Conclusion More than half of RW studies in moderate to severe UC originated from five countries with VEDO and TOFA being the most frequently assessed ATs. Comparative studies were limited. Several definitions of CR were used to describe effectiveness, and few studies assessed PROs and effectiveness beyond 1 year. Inconsistent reporting of safety events was identified. Future research should consider these findings when designing a study.

Autism spectrum disorder (ASD) is a complex brain development condition that includes repetitive behaviors, limited interests, and challenges with social skills and communication. To understand common behavioral issues in children with autism and to learn how parents view the available treatments and their effectiveness. A mixed method study was conducted on Autistic children in Peshawar Autisms center in which a CBCL questionnaire were filled by parents of total sample 250(Open epi with 95%confidence interval) in first phase within 3 months (Nov/2023-jan/2024) while 20 in-depth interviews of 09 questions were taken from their parents in 2nd phase within 15 days (Feb /2024). Random sampling was used for quantitative data while purposive sampling was used for quantitative data collection. The qualitative data was analyzed using Virginia Braun and Victoria Clarke’s thematic analysis method through NVivo 14, while the quantitative data was analyzed using SPSS 26 for measuring frequency, mean and total score. In all, 250 questionnaires were filled by parents of Autistic children with mean age of 3.5years. Among them the most prevalent behavioral issues were aggression (24%), attention problems (19%), withdrawal (16%), and somatic problems (15%). 44 codes were generated from the qualitative interviews, which further divided into 15 categories and emerged into 4 themes. (1) Parental Challenges in Rearing ASD Children, (2) Goals and Effectiveness of early intervention in ASD, (3) Key Components of Successful Autism Management, (4) Parental Satisfaction &amp; Suggestions. Majority of parents (70%) expressed full satisfaction with the available resources for managing autism, and they have observed improvements in their children's behavior like Attention &amp; verbal communication through various early interventions. In Peshawar, early intervention at autism centers helps manage common behavioral issues aggression and attention issues in autistic children. Parents advise seeking timely support and awareness for better outcomes. Keywords: Autism Spectrum Disorder; Child; Parent; Therapies.

Penelitian ini bertujuan untuk mengkaji sejarah awal perkembangan Islam di Indonesia dengan pendekatan studi literatur, berfokus pada teori-teori utama mengenai proses islamisasi, yaitu teori Gujarat, Persia, Arab, dan Cina. Data diperoleh dari buku dan jurnal ilmiah yang relevan, kemudian dianalisis secara deskriptif-analitis untuk mengevaluasi kronologi masuknya Islam, jalur utama penyebaran melalui rute maritim, serta peran masyarakat lokal dalam adaptasi dan penyebaran Islam. Hasil penelitian menunjukkan bahwa islamisasi di Nusantara terjadi melalui jalur damai, seperti perdagangan, pendidikan, dan perkawinan, dengan kontribusi signifikan dari masyarakat lokal dalam mengintegrasikan ajaran Islam ke dalam budaya Nusantara. Penelitian ini memberikan pemahaman holistik tentang dinamika interaksi budaya dalam penyebaran Islam serta mengevaluasi kelebihan dan kekurangan teoriteori yang ada untuk memperkaya kajian sejarah islamisasi di Indonesia. This research aims to examine the early history of the development of Islam in Indonesia using a literature study approach, focusing on the main theories regarding the Islamization process, namely Gujarati, Persian, Arabic and Chinese theories. Data was obtained from relevant scientific books and journals, then analyzed descriptively-analytically to evaluate the chronology of the entry of Islam, the main routes of spread via maritime routes, as well as the role of local communities in the adaptation and spread of Islam. The research results show that Islamization in the archipelago occurred through peaceful channels, such as trade, education and marriage, with significant contributions from local communities in integrating Islamic teachings into Indonesian culture. 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Abstract Background Since advanced therapies (ATs) for moderate to severe UC are increasing, their effectiveness and safety in real-world (RW) settings should be assessed. Methods A SLR was done as per method described by Cochrane Collaboration and PRISMA guidelines, using Embase, MEDLINE and MEDLINE-In Process databases to find RW studies of biologics (adalimumab/ADA, golimumab/GOL, infliximab/IFX, vedolizumab/VEDO and ustekinumab/UST) or small molecules (filgotinib/FIL, ozanimod/OZA and tofacitinib/TOFA) in patients (pts) with UC. Only products approved at the time of search were included. Studies published in English as full papers (Jan-2005–Feb-2022) or congress abstracts (Jan-2019–Feb-2022) were included. Studies with &amp;lt;30 pts or with only bio-naïve pts were excluded. Results Of 3930 results, 139 studies were included (18 comparative and 121 single AT). 13% of studies had only bio-exposed pts, 63% had &amp;gt;50% bio-exposed pts and 28% had subanalysis for bio-exposed pts. Comparative studies of VEDO vs TNF inhibitors (TNFIs; n=10); TOFA vs VEDO (4), TNFIs (3) or UST (1). In comparative effectiveness studies (16), rates of clinical remission (CR) with VEDO were numerically higher vs TNFIs (Fig1). For TOFA vs VEDO, the effectiveness of TOFA in multiple outcomes was numerically (occasionally significantly) greater (Fig2). The study of UST vs TOFA showed similar rates of steroid-free CR (Dalal 2021). In 2 studies, IFX was the most effective TNFI. Comparative safety studies (14) mostly reported % pts with any/serious adverse events (AEs/SAEs) with limited reporting of incidence of MACE and malignancy. A study showed no significant differences in the risk of SAEs (HR0.899;95%CI0.502–1.612) or serious infections (HR1.235;95%CI0.608–2.511) for VEDO vs TNFIs (Lukin 2022). Two studies showed comparable AE rates for TOFA and VEDO. One study showed that VEDO pts had higher chance of experiencing AEs than TOFA pts (OR1.83;95%CI1.10–3.03) but similar number of SAEs (OR0.39;95%CI0.03–4.33; Straatmijer 2022). A study of TOFA vs UST showed similar overall AE rates (Dalal 2021). AE rates for TNFIs were comparable. In single AT studies (VEDO n=50, TOFA 24, ADA 18, GOL 14, IFX 10, and UST 5), % of pts with CR and AEs/SAEs varied widely. No studies were found for FIL and OZA. Conclusion In comparative studies of largely bio-exposed pts, CR rates with TOFA were generally numerically higher vs VEDO and comparable with UST; and numerically higher for VEDO vs TNFIs. IFX was most effective TNFI. SAE rates were similar across ATs. The results should be interpreted cautiously due to varied baseline characteristics though few studies were propensity scores matched. More comparative studies are needed as CR in single AT studies varied widely.

Writing this paper aims to elaborate and explore the determinants and implications of the company's capital structure. Determinants of capital structure including income taxes, profitability, and the size of the company, while the factors that influenced the structure of capital is the return on investment, return on assets, earnings per share, and Tobin's Q. This study is a qualitative as well as literature and is done by comparing the results research or concepts previously been rmapan to obtain confirmation as well as a critique of the research results. The concept used in the discussion is the pecking order theory, capital costs, deductible expenses, economies of scale, as well as leverage and its relation to investment returns, earnings per share, and the stock price. The results of the analysis concluded that from several previous studies found that the relationship between the determinants and effects of capital structure although it varies but can be explained by using the appropriate concept. Advice given on the outcome of this discussion is that in the understanding of social phenomena, including the phenomenon of business, you should use a contingency approach and examined the assumptions underlying concept chosen to criticize the phenomenon of referred business.

426 Background: Continued smoking after a cancer diagnosis is associated with poorer outcomes. Ontario Regional Cancer Centres are required to screen all new cancer patients for tobacco use and offer referrals for cessation support to patients using tobacco. At Princess Margaret Cancer Centre (Toronto, Canada), we leveraged an EMR change to Epic along with uptake in virtual care strategies from COVID-19, to improve both tobacco screening and referral rates for new patients. Methods: Following the EMR transition to Epic in June 2022, we piloted EMR and virtual care strategies from Jan 2023 to Mar 2024 to improve both tobacco screening and referral rates. Due to precautions during COVID-19, screening and referrals were completed using a hybrid pre-visit electronic tobacco use assessment questionnaire and in clinic paper-based referral system. Our interventions were co-developed by a team of hospital leadership, IT team members and clinicians. These included: 1) Collation of tobacco assessment data sources on Epic (Jan 2023); 2) Creation of an Epic referral inbox to track referrals (Aug 2023); 3) Assignment of electronic pre-visit tobacco assessments questionnaires to correct visit types (Sep 2023); 4) Creation of a half-day virtual nursing clinic to offer referrals for cessation support to patients initially declining support or those who were not offered using monthly reports from Epic (Nov 2023). Screening and referral rates were tracked monthly and quarterly during this period. Results: From Jan 2023 to March 2024, 15,063 new patients presented to our cancer centre. Baseline screening and referral rates before COVID-19 were 47% and 16%, respectively. Prior to this QI initiative, screening and referral rates were 18% and 1%, respectively. Post implementation, screening and referral rates improved to 42% and 25% (Table); rates of current tobacco use remained consistent from 12-16%. Collation of tobacco use assessments data on Epic had the greatest impact on improving screening rates from 18% to 39% (p&lt;0.001), while the virtual nursing clinic helped to improve referral rates from 3% to 25% (p&lt;0.001), with the greatest referral rate in Jan 2024 at 36%. Our virtual nursing clinic was feasible, where among patients contacted who initially declined or were not offered cessation support, 90% were contacted within 1-3 phone calls. Among patients contacted, 20% accepted a referral, while 41% of patients had already quit smoking by the time of contact. Conclusions: Both EMR and virtual care strategies helped to successfully improve both tobacco screening and referral rates for smoking cessation support; with the greatest impact from the collation of EMR data sources on tobacco use and development of a virtual nurse led clinic. Quarterly tobacco screening and referral rates. Jan-Mar 2023 Apr-Jun 2023 Jul-Sep 2023 Oct-Dec 2023 Jan-Mar 2024 Screening 33% 38% 39% 41% 42% Referrals 0% 1% 3% 20% 25%

e13549 Background: The scientific literature experienced an unprecedented growth in archived pre-prints and peer-reviewed COVID-19 related publications with regional variations making the task of synthesizing the information burdensome. This study aims to characterize global patterns and domains of COVID-19 research in cancer. Methods: We used the NIH COVID-19 portfolio and Web of Science (WOS) curated databases to extract abstracts using standard search terms for COVID-19 and cancer between Nov 1 2019 and Dec 31 2020. A total of 21,325 publications matched the study search criteria (NIH: 18,029 records; WOS: 3512 records; 204 records overlapped). We performed a descriptive analysis to calculate country citations and intercountry collaboration networks. The Jaccard similarity index was utilized to identify the most frequently co-occurring terms. Latent Dirichlet Allocation (LDA) was used for classifying publications into corresponding research topics. Results: The most productive period was May 2020 with 3,181 published articles, mean citation rate per paper was highest in Jan 2020 (1,620.5) followed by Feb 2020 (236.7), highest mean use rate in the last 12 months was March 2020. Top productive countries are classified as High and Upper Middle-income countries, 17% of research contributed by USA, 12% by China PR, and 11.4% by Italy. Linkage between top 30 productive countries show USA, Italy, and England with the highest inter-country co-ordination. Analysis of keywords co-occurring at least 5 times resulted in 12 major clusters including: 1) cancer treatment and mortality; 2) inflammation and immunology; 3) chronic diseases and co-morbidities; and 4) mental health and social psychology. Ranked topics with the highest volume of publications include 1) effect of COVID-19 on treatment outcomes; 2) individual risk factors of COVID-19 severity and mortality, and 3) novel treatment options relevant to cancer patients [Table]. Growth of articles peaked between Mar and Apr 2020 with a steady decline across all topics in Sept 2020. Conclusions: Global cancer –related research productivity peaked following the declaration of the pandemic and first wave in Mar- Apr 2020. Systematic synthesis of a large volume of COVID-19 literature revealed the global research landscape highlighting focus on the study of outcomes in cancer patients.[Table: see text]

Aim: Dorsolateral prefrontal cortex (DLPFC), Neurological Soft Signs (NSS) and Cognitive impairment have been described as predictors of outcome of First Episode Psychosis (FEP), therefore we aimed to find the predictors of clinical, social and functional outcome variables in a cohort of first episode non affective psychotic subjects. Subjects and Methods: A prospective follow up study was conducted from August 2018 to August 2020 in a tertiary care hospital of South India. A semi-structured questionnaire was given to all subjects for socio-demographic details. All subjects were assessed with Heidelberg scale, Bender Gestalt Test (BGT) and underwent MRI Brain 3D volumetric scan to examine NSS, cognitive impairment, and DLPFC volume at baseline respectively. Brief Psychiatric Rating Scale (BPRS) and Social and Occupational Functioning Assessment Scale scales (SOFAS) were administered at baseline, 1 month and at three month follow up. At 3 months, clinical and socio-functional outcome was defined by BPRS scores and SOFAS scores. Pearson’s correlation was found between DLPFC volume of all subjects, BPRS, BGT scores at baseline with BPRS and SOFAS at 3 months. To test the statistical significance of the comparison of mean values of all continuous clinical and demographic parameters between two groups of BPRS and SOFAS, Mann Whitney U test was used. Results: Smaller DLPFC volume predicted clinical, socio-functional outcome significantly. A significant moderate correlation was found between NSS and BPRS scores at baseline. Conclusion: Baseline right DLPFC volume can be an important predictor of clinical and socio-functional outcome in FEP.

e16089 Background: Immunotherapy has demonstrated promising efficacy and favorable safety profile for unresectable or metastatic gastric cancer (GC) by several high-quality studies. However, few have examined the immunotherapy efficacy for locally advanced GC (LAGC) in the perioperative setting, especially as adjuvant therapy after D2 resection. Here, a phase II trial reports the adjuvant efficacy of camrelizumab with docetaxel plus S-1 in patients (pts) with PD-L1 positive, deficient mismatch repair (dMMR) or Epstein-Barr virus (EBV) positive LAGC (NCT04152889). Methods: This is a single-center, prospective, open-label and single-arm phase II study. Chemotherapy-naive adult pts receiving D2 resection and histologically confirmed as PD-L1 positive (CPS &gt; 5), dMMR or EBV positive LAGC (stage III) were enrolled. Pts received camrelizumab (200mg, D1), docetaxel (40mg/m2, D1, free at first course) and S-1 (80-120mg, D1-14) every 3 weeks for seven courses, sequenced by camrelizumab (200mg, D1) and S-1 (80-120mg, D1-14) every 3 weeks for up to one year, until disease relapse or intolerable toxicity. Primary endpoint was 1-year relapse-free survival (RFS). Herein, the safety and efficacy data after 1-year postoperative therapy courses were reported. Results: From Jan. 2020 to Jan. 2022, 19 pts (median age 59 years, range 34-75, 13 men and 6 women) were enrolled, of whom 15 were CPS &gt; 5, 3 were dMMR, and 1 was EBV positive. pTNM stage IIIA, B and C were 10 (52.6%), 3 (15.8%) and 6 (31.6%), respectively. The cut-off date for the final follow-up data was Feb. 1, 2023 with a median follow-up period for surviving patients of 25.1 months. All 19 pts had experienced treatment related adverse events (TRAEs), of whom, grade 3-4 TRAEs occurred in 9 (47.4%), 2 pts (10.5%) discontinued therapy, and 11 pts (57.9%) delayed the therapy. Furthermore, the OS rate of 19 pts at 1/2 years was 100% and 88.9%, while the RFS rate at 1/2 years was 100% and 92.3%, respectively. The dead and recurrent cases all belonged to PD-L1 positive subgroup. Conclusions: Adjuvant therapy of camrelizumab with docetaxel plus S-1 shows acceptable safety and promising efficacy for PD-L1 positive, dMMR, or EBV positive stage III GC pts after D2 resection. Clinical trial information: NCT04152889 .

The development of Sodium-ion battery technologies and materials is moving rapidly forward, and several companies are on the verge of commercialising their products. An important question is what knowledge and synergies that can be drawn from Lithium-ion batteries. This work has investigated whether the Doyle-Fuller-Newman model (DFN model) [1] can be used for simulating the insertion and extraction of mobile sodium ion in hard carbon. Previous work indicates that this should be the case [2]–[4]. It has been shown that the insertion process of sodium in hard carbon does not follow the same process as for lithium in hard carbon [5]. The sodium insertion in hard carbon is suggested to be a combination of capacitive adsorption, intercalation and nanopore filling [6]–[8]. Hence, the question is if capacitive adsorption and nanopore filling can be simulated as an intercalation process. In addition, the sodium-ion has a lower charge density than lithium-ion, leading to different properties for the electrolyte and the interfacial species [9], [10]. One of the issues with the DFN model is to measure, calculate or estimate the material and electrode properties needed. As a first step in investigating the above assumption, an additional assumption made is that the needed parameters can be extracted using similar methods as for Li-ion batteries. With this starting point, a parameter sensitivity analysis is made for simulating mobile sodium in hard carbon with the DFN model. References [1] M. Doyle, T. Fuller, and J. Newman, “Modeling of galvanostatic charge and discharge of the lithium/ polymer/insertion cell,” J. Electrochem. Soc., vol. 140, no. 6, pp. 1526–1533, 1993, doi: 10.1149/1.2221597. [2] K. Chayambuka, M. Jiang, G. Mulder, D. L. Danilov, and P. H. L. Notten, “Physics-based modeling of sodium-ion batteries part I: Experimental parameter determination,” Electrochim. Acta, vol. 404, p. 139726, Feb. 2022, doi: 10.1016/J.ELECTACTA.2021.139726. [3] K. Chayambuka, G. Mulder, D. L. Danilov, and P. H. L. Notten, “Physics-based modeling of sodium-ion batteries part II. Model and validation,” Electrochim. Acta, vol. 404, p. 139764, Feb. 2022, doi: 10.1016/J.ELECTACTA.2021.139764. [4] C. M. Doyle, “Peer Reviewed Title: Design and Simulation of Lithium Rechargeable Batteries,” 2010. Accessed: Feb. 01, 2021. [Online]. Available: http://www.escholarship.org/uc/item/6j87z0sp [5] H. D. Asfaw, C. W. Tai, M. Valvo, and R. Younesi, “Facile synthesis of hard carbon microspheres from polyphenols for sodium-ion batteries: insight into local structure and interfacial kinetics,” Mater. Today Energy, vol. 18, p. 100505, Dec. 2020, doi: 10.1016/j.mtener.2020.100505. [6] J. Y. Hwang, S. T. Myung, and Y. K. Sun, “Sodium-ion batteries: Present and future,” Chemical Society Reviews, vol. 46, no. 12. Royal Society of Chemistry, pp. 3529–3614, Jun. 21, 2017. doi: 10.1039/c6cs00776g. [7] D. Chen et al., “Hard carbon for sodium storage: mechanism and optimization strategies toward commercialization,” Energy Environ. Sci., vol. 14, no. 4, pp. 2244–2262, Apr. 2021, doi: 10.1039/D0EE03916K. [8] C. Bommier, T. W. Surta, M. Dolgos, and X. Ji, “New Mechanistic Insights on Na-Ion Storage in Nongraphitizable Carbon,” Nano Lett., vol. 15, no. 9, pp. 5888–5892, Sep. 2015, doi: 10.1021/ACS.NANOLETT.5B01969/ASSET/IMAGES/LARGE/NL-2015-01969W_0002.JPEG. [9] R. Mogensen, S. Colbin, and R. Younesi, “An attempt to formulate non‐carbonate electrolytes for sodium‐ion batteries,” Batter. Supercaps, p. batt.202000252, Dec. 2020, doi: 10.1002/batt.202000252. [10] L. A. Ma, A. J. Naylor, L. Nyholm, and R. Younesi, “Strategies for Mitigating Dissolution of Solid Electrolyte Interphases in Sodium-Ion Batteries,” Angew. Chemie - Int. Ed., 2020, doi: 10.1002/anie.202013803.

É com imenso prazer que apresentamos ao público a edição v. 21 n. 1 jan./jun. 2022 da Revista Prisma Jurídico, composta de doze artigos e uma resenha. Prisma Jurídico é um canal de produção científico-acadêmica, que busca o seu aperfeiçoamento para atingir um estrato de excelência.Neste contexto, com características de pluralidade e receptividade, Prisma Jurídico recebe contribuições de autores nacionais e estrangeiros, a fim de garantir uma publicação de qualidade.Para tanto, Prisma Jurídico adota o método double blind peer review, pelo qual cada artigo é avaliado, ao menos por dois pareceristas especialistas na área com elevada titulação acadêmica, bem como são os artigos submetidos a um programa de verificação de similaridade de textos, a fim de se evitar fraudes e todas as modalidades de plágio.A publicação também se preocupa com a endogenia e garante a exogenia, com a efetiva possibilidade de trocas de informações entre as Instituições de Ensino Superior, requisito fundamental para a inserção nas bases indexadoras que emitem fatores de impacto mais elevados, com consequente classificação superior dos periódicos.Este volume inicia com o artigo “A violência segundo uma análise criminológico-cultural: um estudo de caso com base nas consequências de the last of us – parte II”, de Felipe da Veiga Dias e Francielli Bressan que aborda a questão da violência no jogo The Last of Us – part II, quais são as suas consequências e as discussões sobre violência, por meio de uma mídia interativa, com efeitos múltiplos, promovendo importantes análises sobre a reflexão social e os processos discriminatórios existentes em nossa sociedade.Depois, Matheus Ribeiro de Oliveira Wolowski e Valéria Silva Galdino Cardin apresentam o artigo “Responsabilidade civil dos pais por danos decorrentes do uso das tecnologias” que analisa a responsabilidade civil no direito das famílias em decorrência do uso excessivo de tecnologias e da internet por seus filhos, bem como eventual violação aos direitos da personalidade e os danos causados em virtude do uso de excessivo de tecnologias no contexto familiar.Logo em seguida, no artigo a “Proteção jurídica do investidor-consumidor de criptoativos”, Antônio Carlos Efing e Kharen Kelm Herbst estudam os meios de proteção jurídica do consumidor, enquanto investidor no mercado de criptoativos, em especial as falhas existentes em tais serviços e as práticas abusivas dos prestadores de serviços. Ao final, apresentam mecanismos de equiparação do investidor a consumidor, para fins de sujeição passiva à legislação consumerista e às regras dos mercados financeiros, buscando a construção de equilíbrio na relação jurídica, com garantias mínimas, por meio da leitura do direito à informação.Na sequência, Luís Fernando Biasoli e Severino Alexandre Biasoli, no artigo intitulado, “A existência das futuras gerações no direito ambiental de Fraçois Ost” examinam o conceito de responsabilidade intergeracional na A Natureza à Margem da Lei: a Ecologia à Prova do Direito do jurista belga François Ost e os debates dos antropocentristas e biocentristas na atualidade.No quinto artigo, “As bases institucionais das concepções de justiça: uma abordagem a partir de Mary Douglas”, Orlando Villas Bôas Filho se debruça sobre as bases institucionais das concepções de justiça, examinando a visão Émile Durkheim e a “sociologia das instituições” e as concepções de justiça a partir da releitura proposta por Mary Douglas sobre o “O caso dos exploradores de cavernas”, de Lon L. Fuller.Ato contínuo, Álerton Emanuel Poletto e Fausto Santos de Morais, no artigo “A moderação de conteúdo em massa por plataformas privadas de redes sociais” apresentam como proposta uma análise dos desafios do ambiente digital e a proteção dos cidadãos, por meio de propostas legislativas de regulamentação da moderação de conteúdo, a fim de assegurar a manifestação dos usuários e a diminuição de remoção de conteúdo, prejudicial ao espaço público.O sétimo artigo “A urgência da mitigação da publicidade na união estável homoafetiva: direito fundamental à privacidade e os precedentes do Tribunal de Justiça paulista”, Dóris Ghilardi e Mariana Carvalho Bellussi tratam dos precedentes do Supremo Tribunal Federal na Arguição de descumprimento de preceito fundamental (ADPF) 132 e na Ação Direta de Inconstitucionalidade (ADI) 4277, responsáveis pelo reconhecimento da união estável entre pessoas do mesmo sexo, apontando o avanço na conquista dos direitos homoafetivos, bem como a relativização da publicidade que se mostra insuficiente para recepcionar o reconhecimento das uniões estáveis homoafetivas.O artigo seguinte, intitulado “A ‘real’ importância da informação para o processo político em um estado democrático de direito e as sequelas das fake news” de Luis Delcides Rodrigues da Silva e Cátia Rejane Mainardi Liczbinski se dedica a promover uma análise sobre a importância da informação ética e do princípio constitucional do Estado Democrático de Direito, a partir do aumento das Fake News, durante o pleito de 2018, que resultou na eleição de políticos com pouca representatividade na sociedade.Logo depois, Fabiana Marion Spengler e Maini Dornelle, no artigo “Advocacia colaborativa à brasileira: uma análise do PL n. 3813/2020” tratam do procedimento de advocacia colaborativa, que teve origem nos Estados Unidos e do Projeto de Lei n. 3813/2020, em trâmite no Congresso Nacional, que tem por objetivo a obrigatoriedade de realizar sessão extrajudicial de autocomposição de conflitos prévia à propositura de demanda Judicial.O décimo artigo, “A atuação popular pelo direito ao meio ambiente ecologicamente equilibrado frente à injustiça ambiental em zonas residenciais periféricas: um estudo à luz do caso do conjunto Residencial Solar dos Encantos” de Letícia da Silva Ferreira de Lima e Ruan Didier Bruzaca aborda a atuação comunitária na garantia do direito ao meio ambiente saudável, tendo como objeto o caso do Conjunto Residencial Solar dos Encantos, situado no bairro de Forquilha, em São Luís, Estado do Maranhão, localidade afetada pela poluição atmosférica de empresas de transporte.O décimo primeiro artigo de Bibiana Paschoalino Barbosa e Luiz Fernando Kazmierczak, intitulado “A importância da comunicação da prisão em flagrante aos familiares do preso como medida de contenção ao abuso de autoridade” examina a eficácia da comunicação da prisão em flagrante como inibidor do abuso de autoridade.O último artigo intitulado “A dimensão jurídica e econômica do empoderamento feminino” de Samantha Ribeiro Meyer-Pflug Marques e Gina Vidal Marcílio Pompeu examinam a dimensão jurídica e econômica do empoderamento feminino, a partir da Agenda 2030 da Organização das Nações Unidas, bem como no âmbito econômico os aspectos sociais, políticos e trabalhistas dos direitos das mulheres e o papel da empresa na busca da equidade entre homens e mulheres.Por fim, Adriano da Silva Ribeiro apresenta a resenha do livro “Moralidade Administrativa: do histórico em Maurice Hauriou às inconsistências na dogmática jurídica e na jurisprudência do STF” de Thaís Karine de Cristo. Rio de Janeiro: Lumen Juris, 2020”, examinando o estudo do direito público, do direito administrativo e da teoria do direito e o princípio constitucional da moralidade administrativa, a partir das ideias do francês Maurice Hauriou.Novamente Prisma Jurídico contou com o apoio incondicional da nossa Bibliotecária - Editora Técnica, Cristiane dos Santos Monteiro, em todo processo de editoração, sem a qual este número não seria possível de ser realizado.Desejamos, pois, uma boa e agradável leitura aos nossos legentes.Prof. Dr. José Fernando Vidal de SouzaEditor da Revista Prisma Jurídico

Background: VWD is the most common inherited bleeding disorder characterized by defects in the concentration, structure, or function VWF. There are three main types of VWD that differ according to the degree of disease severity and inheritance pattern (Type 1, Type 2A, 2B, 2M, 2N and Type 3). Methodology: This is 05 years study (Feb 2016–Jan 2021) conducted in hematology section. In present study, amongst total inherited bleeding disorders, Incidence of VWD is 27%, Hemophilia (50%), inherited platelet disorders (14%) and remainder are undiagnosed. Amongst VWD, Type 1 VWD is the most common subtype studied, comprising 66% of total cases. Type 2 &amp; 3 VWD comprised 23% and 10% of total cases showing good correlation with the literature and other studies. Discussion: The European cross-sectional study yielded a population-based estimate of 0.05 per 100,000 for type 3 VWD. Estimates by VWD type from Europe and Western Pacific reported higher prevalence estimates for type 1 disease than type 2 or type 3: 2.7–7.2 per 100,000 for type 1 VWD, 0.8–2.5 per 100,000 for type 2, and 0.1–0.3 per 100,000 for type 3. Conclusion: VWD usually presents with mild bleeding symptoms (except in type 3 VWD) the diagnosis is often delayed. Prompt diagnosis and management can help to avoid potentially life-threatening bleeding events and unnecessary exposure to blood products.