Journal articles: 'VS 8107'

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Archer, Gemma, Wei W. Xun, Rachel Stuchbury, Owen Nicholas, and Nicola Shelton. "Are ‘healthy cohorts’ real-world relevant? Comparing the National Child Development Study (NCDS) with the ONS Longitudinal Study (LS)." Longitudinal and Life Course Studies 11, no. 3 (July 1, 2020): 307–30. http://dx.doi.org/10.1332/175795920x15786630201754.

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Comparisons between cohort studies and nationally representative ‘real-world’ samples are limited. The NCDS (1958 British birth cohort) follows those born in Britain in a single week in March 1958 (n=18,558); and the ONS Longitudinal Study (LS) contains linked census data and life events for a 1% sample of the population of England and Wales (> 1 million records; allowing for sub-samples by age, ethnicity, or other socio-demographic factors). Common country-and age-matched socio-demographic variables were extracted from the closest corresponding time-points, NCDS 55-year survey in 2013 (n=8107) and LS respondents aged 55 in 2011 (n=7052). Longitudinal associations between socio-demographic exposures (from the NCDS 46-survey in 2004 and LS respondents aged 45 in 2001) and long-term limiting illness (from NCDS 2013 and LS respondents 2011, aged 55) were assessed using logistic regression. The NCDS 55-year sample had similar characteristics to LS respondents aged 55 for sex and marital status, but the NCDS sample had lower levels of long-term limiting illness (19.7% vs 22.8%), non-white ethnicity (2.1% vs 11.7%) and living in South England (46.9% vs 50.1%), and higher levels of full-time employment (61.2% vs 55.2%), working in professional/higher managerial occupations (35.7% vs 29.2%), and living with a spouse (69.1% vs 64.9%), all p<0.001. Nevertheless, longitudinal associations between socio-demographic exposures and long-term limiting illness were similar in the NCDS and LS samples (all tests of between-study heterogeneity in mutually adjusted models p>0.09) suggesting these NCDS findings are largely generalisable to the population of England and Wales.

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Yang, Yingying, Tingting Yang, Shengxin Liu, Zhijuan Cao, Yan Zhao, Xiujuan Su, Zehuan Liao, Xiaoming Teng, and Jing Hua. "Concentrated ambient PM2.5 exposure affects mice sperm quality and testosterone biosynthesis." PeerJ 7 (November 28, 2019): e8109. http://dx.doi.org/10.7717/peerj.8109.

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Background Studies suggested that PM2.5 exposure could lead to adverse reproductive effects on male animals. However, the underlying mechanism is still not clear. Besides, animals in the majority of previous studies were exposed to PM2.5 through intratracheal instillation which should be improved. In addition, limited amount of research has been conducted in China where the PM2.5 concentration is higher and the PM2.5 components are different. The aim of this work is to explore the effects of concentrated ambient PM2.5 (CAP) on mice sperm quality and testosterone biosynthesis. Methods A total of 12 male C57BL/6 mice were exposed to filtered air (FA) or CAP for 125 days using the Shanghai Meteorological and Environmental Animal Exposure System. The mice sperm concentration, sperm motility, DNA fragmentation index, high DNA stainability and plasma testosterone were analyzed. Testicular histology and sperm morphology were observed through optical microscope. Testosterone biosynthesis related gene expressions were analyzed using real-time PCR, including cytochrome P450 CHOL side-chain cleavage enzyme (P450scc), steroidogenic acute regulatory protein (StAR), 3β-hydroxysteroid dehydrogenase (3β HSD), 17β-hydroxysteroid dehydrogenase, cytochrome P450 aromatase (P450arom), estrogen receptor (ER), androgen receptor (AR) and follicle stimulating hormone receptor (FSHR). Results Exposure to CAP resulted in disturbance of various stages of spermatogenesis and significant higher percentage of abnormal sperm (FA vs. CAP: 24.37% vs. 44.83%) in mice testis. CAP exposure significantly decreased sperm concentration (43.00 × 106 vs. 25.33 × 106) and motility (PR: 63.58% vs. 55.15%; PR + NP: 84.00% vs. 77.08%) in epididymis. Plasma testosterone concentration were significantly declined (0.28 ng/ml vs. 0.69 ng/ml) under CAP exposure. Notably, the levels of testosterone biosynthesis related genes, StAR, P450scc, P450arom, ER and FSHR were significantly decreased with CAP exposure. Conclusion Concentrated ambient PM2.5 exposure altered mice sperm concentration, motility and morphology, which might be mediated primarily by the decline in testosterone concentration and testosterone biosynthesis process.

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Caruso, H., and E. Szymkowiak. "Vibration Test Time Compression and MIL-HDBK-781 vs. MIL-STD-810E." Journal of the IEST 37, no. 1 (January 1, 1994): 24–30. http://dx.doi.org/10.17764/jiet.2.37.1.7g63819660184361.

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This paper defines test time compression issues associated with vibration testing as described in MIL-STD-810E and MIL-HDBK-781. Differences and similarities associated with the test goals and application of each document are examined. Use of these documents for establishing test time compression algorithms related to fatigue life (durability) and reliability evaluations is discussed. Specific inconsistencies between the vibration models in each document for jet aircraft equipment are identified. Recommendations are offered for bringing these documents into agreement to provide increased uniformity and correlation of results throughout a test program.

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Hao, Jun, Yu-zhu Sun, Zi-quan Wu, and Alan Wang. "Model test vs virtual simulation of a VLCC FPSO hookup." Journal of Marine Science and Application 8, no. 2 (May 14, 2009): 137–43. http://dx.doi.org/10.1007/s11804-009-8106-0.

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Bashir, Qaiser, Simrit Parmar, Yvonne Dinh, Sofia Qureshi, Gabriela Rondon, Uday R. Popat, Yago Nieto, et al. "Association of bone marrow plasma cell infiltration pre-auto transplant with adverse outcomes in multiple myeloma." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 8102. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.8102.

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8102 Background: Auto-stem cell transplantation (SCT) has become the standard of care for eligible patients (pts) with multiple myeloma (MM). However, the impact of bone marrow (BM) plasma cell (PC) percentage before SCT is not yet known. Methods: Retrospective review of 1489 MM pts who underwent auto-SCT from 7/8/98 – 12/31/2010 with post-induction, pre-SCT BM biopsy information available. Pts were divided into 2 groups: <10% PC infiltration (“PC low”) and >10% PC infiltration (“PC high”). Progression-free (PFS) and overall (OS) survivals were estimated by the Kaplan-Meier method. Log-rank test was performed to test differences in survival. Results: 1489 pts were studied. 1174 pts had <10% involvement of BM by PCs and 315 had > 10% involvement. For pts in the PC low group, 32% had a CR, 20% had a VGPR, 31% had a PR, 13% had <PR and 3% had progressive disease (PD) after SCT. For pts in the PC high group, 11% had a CR, 14% had a VGPR, 48% had a PR, 21% had <PR and 5% had PD after SCT. Median PFS was significantly shorter for the PC high group vs the PC low group (24.8 vs 29.5 months, p=0.05), as was median OS (52.5 vs 79.4 months respectively, p<0.001). When only pts who had a PR to induction were examined, there was a significant difference in both PFS (24.4 vs 33.2 months, p=0.04) and OS (58.3 vs 81.2 months, p =0.002) for the PC high vs PC low groups, respectively. For the 1299 (87%) pts treated in the era of novel therapeutics (after 2000), the differences between the PC high and PC low groups were maintained for both PFS (24.4 vs 29.5 months respectively (p=0.029)) and OS (54.8 vs 88.4 months respectively, p<0.001). Chemo-mobilization before SCT did not improve PFS or OS but this was done in only 44 (14%) of PC high pts. Conclusions: PC BM infiltration before auto-SCT is associated with a worse outcome. This finding persists in pts with a PR before SCT. Thus BM disease burden may further stratify pts with a PR. Though additional therapy did not significantly change the outcome for pts with high PC burden, this was done only in a minority of pts. Additionally, differences between PC high and PC low groups are maintained despite new salvage agents over the last 10 years. Further prospective study is warranted to determine the true impact of BM PC infiltration.

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Coates, Sally. "Sonography vs excretory urography in acute flank pain." Annals of Emergency Medicine 14, no. 12 (December 1985): 1237. http://dx.doi.org/10.1016/s0196-0644(85)81047-7.

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Cernea, V., N. Todor, O. Coza, and N. Ghilezan. "Hiperfractionated vs. standard radiotherapy of advanced laryngeal cancer." European Journal of Cancer 35 (September 1999): S171. http://dx.doi.org/10.1016/s0959-8049(99)81072-7.

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Kwok, Mary, Neha Korde, Elisabet E. Manasanch, Manisha Bhutani, Irina Maric, Katherine R. Calvo, Adriana Zingone, et al. "Role of immune-related conditions in smoldering myeloma and MGUS." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 8104. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.8104.

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8104 Background: Recent guidelines emphasize tailored follow-up and the need for clinical trials for high-risk smoldering myeloma (SMM). Emerging evidence from epidemiological studies suggests that immune-related conditions play a role in the causation of myeloma precursor disease (SMM and monoclonal gammopathy of undetermined significance; MGUS) and are of clinical importance for the risk of developing multiple myeloma. The aim of our study is to assess whether there is an altered biology in SMM/MGUS patients with preceding immune-related conditions. Methods: From our ongoing prospective SMM/MGUS natural history study, we evaluated 56 SMM and 60 MGUS patients. Information on autoimmunity was identified at baseline. All patients underwent extensive clinical and molecular characterization. At baseline, all patients underwent bone marrow biopsy evaluation using immunohistochemistry and multi-color flow cytometry of plasma cells. We assessed expression patterns of adverse plasma cell markers (CD56 and CD117), and applied risk models based on serum immune markers and bone marrow findings. Results: Among enrolled SMM and MGUS patients, 7 (12%) and 9 (15%) had a preceding autoimmune disorder. We found SMM patients with (vs. without) a preceding autoimmune disorder to have a substantially lower rate of CD56 (28% vs. 61%) and CD117 (28% vs. 61%) expressing plasma cells. When we compared the same markers in MGUS patients, CD56 and CD117 expression patterns were similar among patients with vs. without preceding autoimmunity (10% vs. 17%, and 50% vs. 48%). Using the Mayo Clinic risk model, none of the SMM patients with a preceding autoimmune disorder had high-risk features; in contrast, 3/41 (7%) of those without a preceding autoimmune disorder were high-risk SMM. Using the Mayo Clinic risk model, none of the MGUS patients were high-risk independent of autoimmune status. Conclusions: Our prospective clinical study found SMM patients with preceding immune-related conditions to have less adverse biology, supportive of epidemiological studies suggesting the risk of developing multiple myeloma is substantially lower in these patients.

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West, John B. "The major limitation to exercise performance in COPD is inadequate energy supply to the respiratory and locomotor muscles vs. lower limb muscle dysfunction vs. dynamic hyperinflation." Journal of Applied Physiology 105, no. 2 (August 2008): 758–62. http://dx.doi.org/10.1152/japplphysiol.zdg-8100.pcpcomm.2008.

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Johansen, Jakob, Mogens Karsboel Boisen, Anders Mellemgaard, and Bente Holm. "Prognostic value of ECOG performance status in lung cancer assessed by patients and physicians." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): 8103. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.8103.

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8103 Background: Physician-reported Eastern Cooperative Oncology Group (ECOG) performance status (MD-PS) is a reliable prognostic factor of overall survival (OS) and has a major influence on treatment decisions. MD-PS is also used to quantify cancer patients' general well-being and activities of daily life. The extent and prognostic importance of disagreements between MD-PS and cancer patients' self-reported ECOG PS (Pt-PS) have not been adequately evaluated. Methods: Four hundred and sixty consecutive patients with lung cancer (LC) were referred to the Dept. of Oncology at Herlev University Hospital, Denmark, from February 1 2012 to January 31 2013. Three hundred and forty-seven (75%) of these patients were enrolled in a prospective, longitudinal, LC biomarker study, “LUCAS”. Patients assessed their own Pt-PS in a questionnaire at first visit. Treating physicians scored the MD-PS at first visit. Results: Fifty-four (16%) LUCAS patients had missing PS data (39 no Pt-PS; 14 no MD-PS; 1 neither). LUCAS patients were significantly younger than the total LC population (mean age, 68.1 vs. 71.1; t-test: p < 0.01). The MD-PS and Pt-PS were distributed differently in the LUCAS cohort: PS=0 (121 vs. 76), PS=1 (147 vs. 145), PS=2 (39 vs. 54), PS=3 (25 vs. 30), PS=4 (0 vs. 2) (X2 test: p < 0.01). In 170 (58%) cases the physician and patient were in concordance. In 24 (8%) cases the MD-PS scored the patient in poorer PS compared to the Pt-PS. In 99 (34%) cases the MD-PS scored the patient in better PS than the Pt-PS. In 11 (4%) cases the physician scored a PS value more than 1 different from the patient; all were towards a better PS. The median OS in the total cohort (460 patients) was 9.7 months. MD-PS and Pt-PS were both effective in predicting OS. For patients with MD-PS = 0, a poorer Pt-PS did not significantly predict worse outcome. However, for patients with MD-PS = 1, there was a trend (HR 1.98, p = 0.08; log rank test) towards worse outcome if Pt-PS was > 1. Conclusions: Oncologists and patients frequently disagree regarding PS. The physicians tend to note a better PS score than the patients. The differences between MD-PS and Pt-PS could influence the prognostic value. It may be beneficial in clinical practice to involve patients in PS assessments.

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Neimitz, Andrzej, and Sebastian Lipiec. "Stress Distribution in Front of the Crack - Analytical Solutions vs. Numerical. Can the Differences be Minimized?" Key Engineering Materials 810 (July 2019): 7–14. http://dx.doi.org/10.4028/www.scientific.net/kem.810.7.

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It is shown that it is possible to obtain such material parameters as α and Q, which, when used in the analytical formulae proposed by Hutchinson, Rice and Rosengren and O’Dowd and Shih, can lead to stress distributions similar to those obtained numerically (except for the region at the immediate crack front). The numerical solution obtained after calibration of the stress-strain uniaxial curve and assuming large strains is expected to be close to the “"real” stress distribution. Thus, the analytical solution is also close to the “real” stress distribution. These new values of α and Q can now be used in fracture criteria proposed within the scope of classical nonlinear fracture mechanics.

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Cashy, J., and D. Cella. "Discrepancy analysis of patient vs physician assessments of performance status in patients with advanced lung cancer." Journal of Clinical Oncology 23, no. 16_suppl (June 2005): 8103. http://dx.doi.org/10.1200/jco.2005.23.16_suppl.8103.

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Toliver, Richard. "Ice Is Ice?" Journal of the IEST 31, no. 3 (May 1, 1988): 31–33. http://dx.doi.org/10.17764/jiet.1.31.3.y1421304rgg67121.

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MIL-STD-810D, Method 521.0, "Icing/Freezing Rain," contains guidance for testing equipment exposed to freezing rain. This method was developed around a narrow set of meteorological conditions resulting in the buildup of clear glaze ice. The icing procedures described in Method 521.0 can be applied to a wide range of equipment and will help to predict equipment operations during natural freezing rain. However, the procedures do not give any indication of the operation of equipment during exposure to rime ice. The physical properties of rime and glaze ice differ significantly, as do their effects on equipment. Until MIL-STD-810D is modified to include rime icing, program managers and environmental test engineers will find no guidance or procedures in MIL-STD-810D for half of the icing (rime vs. glaze) that equipment can be exposed to in nature.

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Kim, Jae Hyun, Jin Young Kim, Gun Ha Kim, Donghoon Kang, In Jung Kim, Jeongkuk Seo, Jason R. Andrews, and Chang Min Park. "Clinical Validation of a Deep Learning Algorithm for Detection of Pneumonia on Chest Radiographs in Emergency Department Patients with Acute Febrile Respiratory Illness." Journal of Clinical Medicine 9, no. 6 (June 24, 2020): 1981. http://dx.doi.org/10.3390/jcm9061981.

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Early identification of pneumonia is essential in patients with acute febrile respiratory illness (FRI). We evaluated the performance and added value of a commercial deep learning (DL) algorithm in detecting pneumonia on chest radiographs (CRs) of patients visiting the emergency department (ED) with acute FRI. This single-centre, retrospective study included 377 consecutive patients who visited the ED and the resulting 387 CRs in August 2018–January 2019. The performance of a DL algorithm in detection of pneumonia on CRs was evaluated based on area under the receiver operating characteristics (AUROC) curves, sensitivity, specificity, negative predictive values (NPVs), and positive predictive values (PPVs). Three ED physicians independently reviewed CRs with observer performance test to detect pneumonia, which was re-evaluated with the algorithm eight weeks later. AUROC, sensitivity, and specificity measurements were compared between “DL algorithm” vs. “physicians-only” and between “physicians-only” vs. “physicians aided with the algorithm”. Among 377 patients, 83 (22.0%) had pneumonia. AUROC, sensitivity, specificity, PPV, and NPV of the algorithm for detection of pneumonia on CRs were 0.861, 58.3%, 94.4%, 74.2%, and 89.1%, respectively. For the detection of ‘visible pneumonia on CR’ (60 CRs from 59 patients), AUROC, sensitivity, specificity, PPV, and NPV were 0.940, 81.7%, 94.4%, 74.2%, and 96.3%, respectively. In the observer performance test, the algorithm performed better than the physicians for pneumonia (AUROC, 0.861 vs. 0.788, p = 0.017; specificity, 94.4% vs. 88.7%, p < 0.0001) and visible pneumonia (AUROC, 0.940 vs. 0.871, p = 0.007; sensitivity, 81.7% vs. 73.9%, p = 0.034; specificity, 94.4% vs. 88.7%, p < 0.0001). Detection of pneumonia (sensitivity, 82.2% vs. 53.2%, p = 0.008; specificity, 98.1% vs. 88.7%; p < 0.0001) and ‘visible pneumonia’ (sensitivity, 82.2% vs. 73.9%, p = 0.014; specificity, 98.1% vs. 88.7%, p < 0.0001) significantly improved when the algorithm was used by the physicians. Mean reading time for the physicians decreased from 165 to 101 min with the assistance of the algorithm. Thus, the DL algorithm showed a better diagnosis of pneumonia, particularly visible pneumonia on CR, and improved diagnosis by ED physicians in patients with acute FRI.

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Gambini, O., V. Barbieri, and S. Scarone. "Theory of Mind in schizophrenia: First person vs third person perspective." Consciousness and Cognition 13, no. 1 (March 2004): 39–46. http://dx.doi.org/10.1016/s1053-8100(03)00046-1.

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Drid, Patrik, Saša Krstulović, Marko Erceg, Tatjana Trivić, Marko Stojanović, and Sergej M. Ostojić. "The effect of rapid weight loss on body composition and circulating markers of creatine metabolism in judokas." Kinesiology 51, no. 2 (2019): 158–60. http://dx.doi.org/10.26582/k.51.2.3.

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We evaluated the effects of a 7-day rapid weight loss (RWL) intervention on body composition and biomarkers of creatine metabolism in eight elite judokas during a pre-competition period. RWL induced a significant drop in weight (81.7±10.7 kg at baseline vs. 76.8 ± 10.3 kg at follow-up; p<.001), fat mass (12.6±5.6 kg vs. 9.2±4.0 kg; p=.003) and fat-free mass (69.1±7.3 kg vs. 67.6±7.7 kg; p=.05), accompanied by an increase in serum creatinine levels at follow-up (104.0±10.5 µmol/L vs. 114.9±10.2 µmol/L; p=.009). An acute restriction of food and fluid intake appears to negatively affect fat-free mass and indices of kidney function in judokas.

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Kandaswamy, R. "Laparoscopic vs open nephrectomy in 210 consecutive patients: outcomes, cost, and changes in practice patterns." Surgical Endoscopy 18, no. 11 (October 11, 2004): 1684. http://dx.doi.org/10.1007/s00464-004-8137-1.

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Riethmueller, J., M. Ballmann, T. W. Schroeter, P. Franke, R. von Butler, A. Claass, S. Junge, G. Doering, and M. Stern. "Tobramycin once- vs thrice-daily for elective intravenous antipseudomonal therapy in pediatric cystic fibrosis patients." Infection 37, no. 5 (September 5, 2009): 424–31. http://dx.doi.org/10.1007/s15010-009-8117-4.

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Yang, Yu-Tao, San-Yuan Dong, Jue Zhao, Wen-Tao Wang, Meng-Su Zeng, and Sheng-Xiang Rao. "CT-detected extramural venous invasion is corelated with presence of lymph node metastasis and progression-free survival in gastric cancer." British Journal of Radiology 93, no. 1116 (December 1, 2020): 20200673. http://dx.doi.org/10.1259/bjr.20200673.

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Objective: This study aimed to investigate if CT-detected extramural venous invasion (ctEMVI) was associated with the presence of lymph node metastasis (LNM) and survival outcomes in patients with gastric cancer. Methods: We retrospectively reviewed 105 patients with pathologically proved gastric cancer who underwent pre-operative CT examinations and received radical gastrectomy with extended lymphadenectomy. Differences in CT characteristics between the LNM-positive and -negative groups were assessed by two observers. Binary logistic regression analysis was performed to determine the risk factors of lymph node metastasis in gastric cancer. Progression-free survival analysis was performed by Kaplan–Meier method. Results: Two observers reached good inter-reader agreements in ctEMVI and ctN status with κ values of 0.711 and 0.751, respectively. The frequency of ctEMVI-positive status was 58.1% (61/105) in patients with gastric cancer. The LNM-positive group showed higher possibility of ctEMVI-positive status (81.7% vs 26.7%, p＜0.001), larger tumor volume (mean volume, 40.77 vs 22.09 mL, p＜0.001), poor tumor margin (45.0% vs 26.7% , p = 0.054) and high enhancement on arterial phase (43.3% vs 26.7%, p = 0.023) and venous phase (60.0% vs 44.4%, p = 0.048), than LNM-negative group. In multivariate analysis, ctEMVI status and tumor volume were identified as independent risk factors for lymph node metastasis with odds ratio (OR) of 9.804 (95% CI, 3.076－31.246; p＜0.001) and 1.030 (95% CI, 1.001－1.060; p = 0.044). CT-detected EMVI presented better diagnostic efficiency for lymph node metastasis than CT-defined N status, with sensitivity (81.7% vs 70.0%), specificity (73.3% vs 71.1%), accuracy (78.1% vs 70.5), PPV (80.3% vs 76.4%), and NPV (75.0% vs 64.0%), respectively. Kaplan–Meier curves showed that patients with positive ctEMVI findings has lower PFS rate than patients with negative ctEMVI findings (Log-rank test, p = 0.007). Conclusion: CT-detected EMVI was significantly associated with lymph node metastasis and progression free survival in patients with gastric cancer. Compared to CT-defined N status, ctEMVI provided superior diagnostic performance to predict pathologic Nstatus. Advances in knowledge: Our study proved that CT-detected EMVI is a promising imaging marker to predict lymph node metastasis and poor prognosis, which may contribute to the precise evaluation of gastric cancer before surgery.

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Barclay, Meagan, Allen F. Ryan, and Gary D. Housley. "Type I vs type II spiral ganglion neurons exhibit differential survival and neuritogenesis during cochlear development." Neural Development 6, no. 1 (2011): 33. http://dx.doi.org/10.1186/1749-8104-6-33.

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Lantuejoul, Sylvie, Isabelle Rouquette, Hugues Begueret, Helene Blons, Frederique Penault-Llorca, Marie-Christine Copin, Martine Antoine, et al. "A French multicentric and prospective validation study for ALK translocation diagnosis in lung adenocarcinomas." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): 8100. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.8100.

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8100 Background: ALK rearrangements occur in nearly 5% of NSCLC and lead to a permanent ALK protein activation, targeted by a small molecule, the crizotinib. To date, FISH (Fluorescent In situ Hybridization) is considered as the gold standard to identify ALK abnormalities, but dual testing and pre-screening by immunohistochemistry have been proposed. Methods: The purpose of the study was to compare immunohistochemistry (IHC) using 5A4 and D5F3 Abs, with FISH and quantitative RT-PCR in a series of 500 surgical specimens, collected within one year from 15 French Thoracic Pathology Departments and INCa genetic platforms. Our study was deliberately enriched in ALK positive cases and clinicopathological data were recorded. Results: Among the 459 cases included to date, 340 were both FISH and IHC ALK negative, and 85 were ALK FISH and IHC positive. Fifteen cases were FISH neg/IHC pos, but with low staining scores; 12 cases were FISH pos/IHC neg, most provided by two centers. Seven cases were non interpretable by FISH, but 5 were ALK IHC positive. Regarding RTqPCR, nearly 50% of ALK positive cases presented a variant 1, 30% a variant 3a/b, and less than 5%, variants 2 or 7; 20%were negative or non interpretable. Discordant cases will be further discussed according to the crizotinib response. ALK positive patients were more frequently women (65 vs 42%) and younger than ALK negative patients (mean age 59 vs 64yrs); 72% were non or light smokers, whereas 75% of ALK negative patients were smokers (mean of 41PY). Histologically, most ALK positive and negative tumors presented a solid or acinar predominant architecture and were P63 negative. However, ALK positive tumors were more frequently TTF1 positive (91 vs 76%). Conclusions: 5A4 or D5F3 immunohistochemistry is a reliable and easy technique for routine diagnosis of ALK abnormalities, while FISH and RT-qPCR still dependent on pre-analytic conditions and technical expertise. However, in case of a suggestive clinical presentation, double testing with FISH remains the safer testing option as false negative IHC cases exist.

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Tian, Xue, Fenghu Li, Ran Li, Feiyue Yang, Jianying Chang, Jiehui Li, Lili Hu, et al. "A new perspective of different schemes of neoadjuvant chemotherapy followed by concurrent chemotherapy and radiotherapy for locally advanced cervical cancer." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): e18011-e18011. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e18011.

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e18011 Background: To observe the clinical effect, survival time and toxicity and side effects in unoperated cervical cancer patients treated with different schemes of neoadjuvant chemotherapy (NACT) followed by concurrent chemotherapy and radiotherapy (CCRT). Methods: A retrospective analysis was performed in 120 patients who were followed up until they died or being followed up at least 5 years. The treatment schedules consisted of 2 cycles of intravenous paclitaxel 135-175 mg/m2 plus cisplatin 60-80mg/m2 (TP group, 62 patients) or lobaplatin 30mg/m2 (TL group, 58 patients) every 21 days. Patients were then submitted to CCRT. Chemotherapy regimen of CCRT was cisplatin 40 mg/m2 (TP group) or lobaplatin 30mg/m2 (TL group) weekly. External beam radiation therapy (total 50.4-56.35Gy, 28 fractions, 180-215cGy per fraction daily) was administered using the3D-CRT or IMRT followed by intracavitary brachytherapy (5Gy per fractions, mostly 5 fractions, Ir192 based). Results: The proportion who had a complete/partial response was 81.7% after NACT, and 99.2% after all treatment. In all patients, the one-year, three-year and five-year survival rates were 99.2%, 81.7% and 69.2% respectively. In TP group vs. TL group, the 3-yr and 5-yr survival rates were 85.5% vs.77.6% (χ2= 1.248, p = 0.264) and 75.8% vs. 63.8% (χ2= 2.059, p = 0.151) with no significant difference. In mass size ≥ 5cm group vs. <5cm group, 3-yr survival rates were 88.0% vs.77.1% with no significant difference (χ2= 2.296, p = 0.130), but 5-yr survival rates were 82.0% vs.61.4% (χ2= 5.878, p = 0.015) with significant difference. The 3-yr and 5-yr OS rates between stage IIB and stage IIIB were not significantly different, respectively 83.1% vs. 70.6% (χ2= 2.083, p = 0.149) and 67.7% vs. 64.7% (χ2= 0.090, p = 0.765) . In TP group, grade 3 or 4 digestive reaction was obviously more frequent than TL group, respectively 54.3% vs. 1.8%(p = 0.000). Neutropenia and thrombocytopenia are more common in TL group than TP group, respectively 48.3% vs. 30.6%(p = 0.0.048) and 44.8% vs. 1.6%(p = 0.000). Conclusions: For patients with severe digestive system reaction or contraindications of cisplatin, lobaplatin was might be used as an alternative drug. A prospective research is undergoing in our hospital. NACT may improve the prognosis of patients with large-scale mass. A undergoing prospective study protocol was approved by the Ethics Committee of hospital number 2017-02 and was registered in ClinicalTrial.gov as ChiCTR-IIR-17011559.

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Aggarwal, Charu, Suzanne Eleanor Dahlberg, Nasser Hanna, Jill Kolesar, Fred R. Hirsch, Suresh S. Ramalingam, and Joan H. Schiller. "Exploratory biomarker analyses from ECOG 4508: Three-arm randomized phase II study of carboplatin (C) and paclitaxel (P) in combination with cetuximab (CET), IMC-A12, or both for advanced non-small cell lung cancer (NSCLC) patients (pts)." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): 8106. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.8106.

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8106 Background: ECOG 4508 was a phase II study that randomized advanced NSCLC pts that were not candidates for bevacizumab to receive: C + P iv on day 1 every 3 wks with either CET iv weekly (arm A, n=39), IMC-A12 iv every 2 wks (arm B, n=42), or both (arm C, n=48). The study was closed prematurely due to safety concerns after 129 eligible pts were treated. The study failed to meet its primary objective (Hanna et al ASCO 2012). Methods: Tumor samples were analyzed by immunohistochemistry (IHC; EGFR, IGF-1R and IGF-2R expression), fluorescent in-situ hybridization (FISH; EGFR gene copy number) and DNA sequencing (EGFR, KRAS gene mutations). Time-to-event distributions were estimated using the Kaplan-Meier method, and differences were tested using the logrank test. Cox proportional hazards models were fitted to estimate hazard ratios. Results: Histology: 38% squamous cell, 39% adenocarcinoma, 2% BAC, 5% NOS and 6% other. OS was similar in EGFR FISH+ (Colorado classification system, n=30/70, 43%) vs EGFR FISH- pts (57%), (9.5 mos vs 8.6 mos, HR=0.62, p=0.08). For EGFR FISH+ pts, there was no difference in outcomes with CET (n=19, OS=9.7 mos, PFS=4.1 mos) vs no CET (n=11, OS=9.5 mos, PFS=5.5 mos). EGFR and KRAS mutations were detected in 6% (5/80) and 22% (6/27) of the pts respectively, but sample sizes were not large enough for robust testing. EGFR and IGFR IHC hybrid (H) scores were assessed on 98/102 available samples (Arm A=29, Arm B=34, Arm C=35). Median H scores (and range): IGF-1R: 190 (30-390), IGF-2R: 145 (20-350), EGFR membrane and cytoplasm: 190 (0-380) and EGFR membrane only: 160 (0-390). With IGF-1R and IGF-2R H score > 200, there was no association with OS (HR 1.3, p=0.26; HR 1.4, p=0.28) or PFS (HR=1.1, p=0.67; HR=1.2, p=0.56), adjusted for whether or not IMCA12 was received. Similarly, no associations with OS or PFS were seen with EGFR membrane H score > 200, adjusted for CET administration (OS HR=0.89, p=0.64; PFS HR 1.1, p=0.62). Conclusions: There was no correlation between EGFR FISH or H score and outcomes with CET. IGF-1R and IGF-2R expression was not predictive of favorable outcome with IMC-A12. Clinical trial information: NCI-2011-01976.

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Ganakammal, Satishkumar Ranganathan, and Emil Alexov. "Evaluation of performance of leading algorithms for variant pathogenicity predictions and designing a combinatory predictor method: application to Rett syndrome variants." PeerJ 7 (November 27, 2019): e8106. http://dx.doi.org/10.7717/peerj.8106.

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Background Genomics diagnostic tests are done for a wide spectrum of complex genetics conditions such as autism and cancer. The growth of technology has not only aided in successfully decoding the genetic variants that causes or trigger these disorders. However, interpretation of these variants is not a trivial task even at a level of distinguish pathogenic vs benign variants. Methods We used the clinically significant variants from ClinVar database to evaluate the performance of 14 most popular in-silico predictors using supervised learning methods. We implemented a feature selection and random forest classification algorithm to identify the best combination of predictors to evaluate the pathogenicity of a variant. Finally, we have also utilized this combination of predictors to reclassify the variants of unknown significance in MeCP2 gene that are associated with the Rett syndrome. Results The results from analysis shows an optimized selection of prediction algorithm and developed a combinatory predictor method. Our combinatory approach of using both best performing independent and ensemble predictors reduces any algorithm biases in variant characterization. The reclassification of variants (such as VUS) in MECP2 gene associated with RETT syndrome suggest that the combinatory in-silico predictor approach had a higher success rate in categorizing their pathogenicity.

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Sultan, Amir, Riffat Asim Pasha, Sayyid Masood Ur Rehman Shah, Haris Ali, and Asim Zulfiqar. "Fatigue Crack Growth Behaviour of AISI 50100 Precipitation Hardened Steel after Welding." Advanced Materials Research 570 (September 2012): 9–14. http://dx.doi.org/10.4028/www.scientific.net/amr.570.9.

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Single-edged notched tension (SENT) specimen is used to study the fatigue crack growth rate (FCGR) behavior of AISI 50100 steel using MTS 810. Calibration tests are run to get plots of crack mouth opening displacement (CMOD) vs. Load and CMOD vs. Crack length to width ratio with the known crack lengths. FCGR of welded and un-welded specimens are plotted against stress intensity range to show the effect of welding on fatigue crack growth rate of AISI 50100 steel, initial results of the experimentation are presented.

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Vollebergh, M. A., I. Kappers, M. M. van den Heuvel, J. C. Buning-Kager, C. M. Korse, J. M. Bonfrer, M. Hauptmann, K. E. de Visser, H. M. Klomp, and S. C. Linn. "Ligands of EGFR and the insulin-like growth factor family as serum biomarkers for response to EGFR-inhibitors in patients with advanced NSCLC." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): 8100. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.8100.

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8100 Background: To determine whether concentrations of transforming growth factor α (TGFa), amphiregulin (ARG), both ligands of the epidermal growth factor receptor (EGFR), insulin-like growth factor 1(IGF1) or IGF-binding protein 3 (IGFBP3) measured in serum of advanced non-small cell lung cancer (NSCLC) patients are predictive of EGFR-inhibitors (EGFRi) response. Methods: We assessed serum levels of marker candidates using ELISA (TGA and ARG) and chemiluminescent (IGF1 and IGFBP3) assays. Sixty-one advanced NSCLC patients treated with EGFRi (gefitinib or erlotinib, >14 days) were matched for gender, age and histology to a control group of 63 EGFRi-untreated advanced NSCLC patients. We dichotomized marker levels at the 20th, 50th or 80th percentile and evaluated whether the effect of EGFRi treatment on overall survival (OS) differed by marker level based on multivariate proportional hazards regression with an interaction term. We adjusted for gender, smoking, stage, histology and prior chemotherapy. Results: While 6-months OS did not appreciably differ between 50 EGFRi treated and 50 control patients whose TGFa levels were below the 80th percentile (39% vs. 54%, multivariate HR 0.78, 95% CI 0.45–1.34, p=0.359), it was substantially worse for 11 EGFRi treated patients compared with 13 control patients whose TGFa levels were high (9% vs. 42%, multivariate HR 2.38, 95% CI 0.87–6.52, p=0.092). The difference of EGFRi effects by TGFa level was statistically significant (interaction p=0.033). There was no evidence that EGFRi treatment effects differed by levels of ARG, IGF1 and IGFBP3. Patients with high concentrations of IGFBP3 (above the median) had significantly longer OS than patients with low IGFBP3 concentrations, independent of treatment (HR 0.46, 95% CI 0.29–0.73, p=0.001). Conclusions: This is the first study in NSCLC patients of Caucasian origin in which serum concentrations of TGFa are predictive for EGFR-inhibitor response, suggesting this is a potential predictive marker for EGFRi treatment. Furthermore, we coincidentally found that levels of IGFBP3 are predictive for overall survival, indicating this might be a prognostic factor in advanced NSCLC patients. [Table: see text]

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Tom, Cynthia M., Roy P. Won, Scott Friedlander, Rie Sakai-Bizmark, Christian De Virgilio, and Steven L. Lee. "Impact of Children's Hospital Designation on Outcomes and Costs after Cholecystectomy in Adolescent Patients." American Surgeon 84, no. 10 (October 2018): 1547–50. http://dx.doi.org/10.1177/000313481808401001.

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Variations in the management of adolescents at children's hospitals (CHs) and nonchildren's hospitals (NCHs) have been well described in the trauma literature. However, the effects of CH designation on outcomes after common general surgical procedures have not been investigated. The purpose of this study was to compare the outcomes and costs of adolescent cholecystectomies performed at CHs and NCHs. Within the California State Inpatient Database (2005–2011), we identified 8117 cholecystectomy patients aged 13 to 18 years at CHs and NCHs. Outcomes (laparoscopy, intraoperative cholangiogram, length of stay (LOS), and complications) and costs were analyzed. CHs cared for younger patients, more uninsured patients, and more black patients. NCHs were associated with higher laparoscopy use (95.7% vs 88.3%, P < 0.01), higher intra-operative cholangiogram rates (28.8% vs 11.9%, P < 0.001), shorter LOS (3.2 vs 5.0 days, P < 0.01), and lower costs by $5797 per patient ($11,219 vs $17,016, P < 0.01). Although there was no significant difference in overall complication rates, CHs had higher rates of infectious complications (2.0% vs 1.0%, P = 0.004). Adolescent cholecystectomies are safely performed at NCHs while achieving increased laparoscopy use, shorter LOS, and lower costs compared with CHs.

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Benway, B. M., A. J. Wang, J. M. Cabello, and S. B. Bhayani. "810 ROBOTIC PARTIAL NEPHRECTOMY VS. LAPAROSCOPIC PARTIAL NEPHRECTOMY: A COMPARISON OF OPERATIVE DATA AND CLINICAL OUTCOMES." European Urology Supplements 8, no. 4 (March 2009): 323. http://dx.doi.org/10.1016/s1569-9056(09)60798-3.

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Mattar, Hebatallah, Mohamed Bahgat, Amir Ezzat, Bassant Bahaa El-Din, Khaled Keraa, and Iman El Taftazany. "Management of peri-implantitis using a diode laser (810 nm) vs conventional treatment: a systematic review." Lasers in Medical Science 36, no. 1 (August 12, 2020): 13–23. http://dx.doi.org/10.1007/s10103-020-03108-w.

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OZTURAN, BURAK, SAMET ERINC, TAYYAR TAYLAN OZ, and KORHAN OZKAN. "NEW GENERATION NAIL VS. PLATE IN THE TREATMENT OF UNSTABLE INTERTROCHANTERIC FEMORAL FRACTURE." Acta Ortopédica Brasileira 28, no. 6 (December 2020): 311–15. http://dx.doi.org/10.1590/1413-785220202806234631.

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ABSTRACT Objective: To compare antirotator proximal femoral nail (A-PFN) with antirotator dynamic hip screw (A-DHS). Methods: Fourteen proximal femur models with type 31/A2 fracture, according to the AO Foundation/Orthopaedic Trauma Association (AO/OTA) classification, were separated into two groups. Group 1 bones (n = 7) were fixed with A-PFN and Group 2 (n = 7) with A-DHS. A 5 mm/min axial load was applied to femur heads using a testing device. Results: Two of the seven models in the A-PFN group fractured at the proximal, and the other five at distal locking screw level. All models in the A-DHS group fractured at the tightened distal screw region. The median fracture load for the A-PFN group was 132.1 N (97.1-173.69 N range), and for the A-DHS group it was 81.7 N (75.15-89.12 N range). Conclusion: A-PFN-treated unstable intertrochanteric fractured models resisted to higher levels of axial load than the A-DHS-treated group, with statistically significant difference. However, clinical studies are required to support these results. Level of Evidence V, Biomechanical study.

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Tawiah, Richard, Kaarin Anstey, Carol Jagger, and Kim Kiely. "Area-Level Disadvantage and Changes in Disability-Free Life Expectancy for Older Australians." Innovation in Aging 4, Supplement_1 (December 1, 2020): 640–41. http://dx.doi.org/10.1093/geroni/igaa057.2198.

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Abstract We report the first analysis of inequalities in Disability-Free Life Expectancy (DFLE) trends for Australia, based on two cohorts of the nationally representative Household Income and Labour Dynamics in Australia survey. Each cohort was aged 45+ at baseline with 7-years of annual follow-up (Older cohort: 2001-2007, n=6363; Younger cohort: 2011-2017, n=8197). Disability was defined by a Global Activity Limitation Indicator, and socioeconomic position (SEP) by an area-level index of disadvantage. Compared to men in high advantage areas, men residing in low advantage areas experienced smaller gains in life expectancy (3.0 vs 4.6 years at age 65), DFLE (0.6 vs 1.8 years) and years with disability (2.4 vs 2.8 years). In contrast, for women in low advantage areas all years gained in life expectancy (2.6 years) were years with disability, whereas women in high advantage areas experienced gains in DFLE (1.7 years) and even more years with disability (2.7 years).

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Komeda, Yoriaki, Hisashi Handa, Ryoma Matsui, Shohei Hatori, Riku Yamamoto, Toshiharu Sakurai, Mamoru Takenaka, et al. "Artificial intelligence-based endoscopic diagnosis of colorectal polyps using residual networks." PLOS ONE 16, no. 6 (June 22, 2021): e0253585. http://dx.doi.org/10.1371/journal.pone.0253585.

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Convolutional neural networks (CNNs) are widely used for artificial intelligence (AI)-based image classification. Residual network (ResNet) is a new technology that facilitates the accuracy of image classification by CNN-based AI. In this study, we developed a novel AI model combined with ResNet to diagnose colorectal polyps. In total, 127,610 images consisting of 62,510 images with adenomatous polyps, 30,443 with non-adenomatous hyperplastic polyps, and 34,657 with healthy colorectal normal mucosa were subjected to deep learning after annotation. Each validation process was performed using 12,761 stored images of colorectal polyps by a 10-fold cross validation. The efficacy of the ResNet system was evaluated by sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy. The sensitivity, specificity, PPV, NPV, and diagnostic accuracy for adenomatous polyps at WLIs were 98.8%, 94.3%, 90.5%, 87.4%, and 92.8%, respectively. Similar results were obtained for adenomatous polyps at narrow-band imagings (NBIs) and chromoendoscopy images (CEIs) (NBIs vs. CEIs: sensitivity, 94.9% vs. 98.2%; specificity, 93.9% vs. 85.8%; PPV, 92.5% vs. 81.7%; NPV, 93.5% vs. 99.9%; and overall accuracy, 91.5% vs. 90.1%). The ResNet model is a powerful tool that can be used for AI-based accurate diagnosis of colorectal polyps.

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Joyce, A. T., D. J. Harrison, S. Jun, A. L. Feliu, and M. Anthony. "Risk of renal failure associated with IV bisphosphonate use in patients with multiple myeloma." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 8104. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.8104.

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8104 Background: IV Bisphosphonates including zoledronic acid (ZA) and pamidroniate are frequently used to delay time to skeletal related events in patients with multiple myeloma. The risk of renal toxicity with these agents is well known and regular monitoring of kidney function is required. Despite regular monitoring of creatinine, patients taking IV bisphosphonates may experience decreased renal functioning and renal failure. The purpose of this study was to determine the relative risk of renal failure in patients with multiple myeloma treated with ZA or pamidronate relative to patients whose lytic lesions remained untreated with medications. Methods: Commercially insured adults newly diagnosed with multiple myeloma 7/1/2002–6/2006 were identified using ICD-9 codes within the PHARMetrics Integrated Outcomes Database. Patients were stratified based on evidence of IV bisphosphonate use (treated) or no such evidence (untreated) following initial qualifying diagnosis. For treated patients, the date of first administration of an IV bisphosphonate was the patient's index date. Treated patients were matched to untreated patients based on use of radiation therapy or chemotherapy, year of cancer diagnosis, and health plan enrollment duration.The incidence rate (IR) for renal failure defined using ICD-9 codes was based on number of incident cases identified among the total person-years at risk and expressed as a rate per patient year. IRs and incidence rate ratios (IRR) (comparing the treated to untreated cohorts), with corresponding 95% confidence intervals are reported. Results: Treated (n=401) and untreated (n=431) patients were similar with respect to age (mean 56 years in both cohorts), but treated patients were more likely to be female (54% vs. 47%; p = 0.04) and less likely to have a history of anemia (48% vs. 51%; p=0.002). IV bisphosphonate use was associated with an 8.5% incidence of developing renal failure per patient year versus 4.9% in the untreated cohort (IRR 1.72; 95% CI 1.22–2.42). The risk was similar whether patients were treated with ZA or pamidronate. Conclusions: IV bisphosphonate use was associated with a significantly increased risk (72%) of developing renal failure in patients with multiple myeloma. No significant financial relationships to disclose.

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Solomon, Benjamin J., Scott N. Gettinger, Gregory J. Riely, Shirish M. Gadgeel, Hiroshi Nokihara, Ji-Youn Han, Toyoaki Hida, et al. "Subgroup analysis of crizotinib versus either pemetrexed (PEM) or docetaxel (DOC) in the phase III study (PROFILE 1007) of advanced ALK-positive non-small cell lung cancer (NSCLC)." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): 8105. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.8105.

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8105 Background: PROFILE 1007 compared the efficacy and safety of crizotinib with that of standard-of-care chemotherapy in patients with ALK+ NSCLC. Although the study was not designed for formal assessment of patient outcomes on crizotinib vs. PEM or crizotinib vs. DOC, due to later interest, we performed retrospective efficacy and safety analyses of patient subgroups treated with crizotinib or each chemotherapy individually. Methods: Patients with stage IIIB/IV ALK+ NSCLC previously treated with 1 prior platinum-based regimen were randomized to receive crizotinib 250 mg PO BID or chemotherapy (PEM 500 mg/m2 or DOC 75 mg/m2, IV q3 wk). Patients with progressive disease on chemotherapy were offered crizotinib treatment in a separate study. In these subgroup analyses, PFS and ORR based on independent radiologic review, and safety were evaluated. Results: Of 347 patients randomized, 172 received crizotinib, 99 PEM, 72 DOC, and 4 no treatment. At data cutoff (Mar 2012), 85 crizotinib patients, 21 PEM patients, and 7 DOC patients were receiving treatment. Median treatment duration was longer in the crizotinib arm (7.1 mo) than in either the PEM (4.1 mo) or DOC (2.1 mo) treatment subgroups. Median PFS was significantly longer on crizotinib (7.7 mo) than on either PEM (4.2 mo; HR, 0.59; P=0.0004) or DOC (2.6 mo; HR, 0.30; P<0.0001). 1-year PFS rates were 31% on crizotinib, 16% on PEM, and 6% on DOC. The ORR on crizotinib (66%) was significantly higher than on either PEM (29%; risk ratio, 2.31; P<0.0001) or DOC (7%; risk ratio, 9.65; P<0.0001). The most common all-causality adverse events with crizotinib were diarrhea (60%), vision disorder (60%), and nausea (55%); with PEM, nausea (38%), fatigue (36%), and decreased appetite (26%); and with DOC, alopecia (47%), neutropenia (43%), and nausea (36%). Conclusions: Crizotinib’s superior efficacy over chemotherapy, with a distinct but generally tolerable and manageable side effect profile in patients with advanced ALK+ NSCLC, was also observed in separate comparisons with either PEM or DOC. In patients receiving chemotherapy, median PFS, 1-year PFS rates, and ORR were all numerically higher on PEM than on DOC. Clinical trial information: NCT00932893.

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Hirsh, Vera, Fiona Helen Blackhall, Dong-Wan Kim, Benjamin Besse, Hiroshi Nokihara, Ji-Youn Han, Vanessa Roberts Tassell, Arlene Reisman, Shrividya Iyer, and Alice Tsang Shaw. "Impact of crizotinib on patient-reported symptoms and quality of life (QOL) compared with single-agent chemotherapy in a phase III study of advanced ALK+ non-small cell lung cancer (NSCLC)." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): 8108. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.8108.

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8108 Background: PROFILE 1007 compared the efficacy and safety of the ALK inhibitor crizotinib (N=172) with that of standard-of-care chemotherapy (pemetrexed [PEM; N=99] or docetaxel [DOC; N=72]) in patients with advanced ALK+ NSCLC. The primary endpoint was progression-free survival. The main objective of our present post-hoc analyses was to compare patient-reported outcomes in the crizotinib arm with those of the DOC and PEM subgroups in the chemotherapy arm. Methods: Patient-reported outcomes were assessed at baseline, on day 1 of each cycle, and at the end of treatment using EORTC QLQ-C30 and lung cancer module QLQ-LC13. Higher scores (range 0−100) indicate higher symptom severity or better functioning/QOL. Time to deterioration (TTD) was defined as time from randomization to the earliest time with a ≥10-point increase from baseline for pain in chest, dyspnea, or cough and was compared between groups using an unstratified log-rank test. Repeated measures mixed-effects analyses were performed to compare change from baseline scores, with no adjustment for multiple comparisons. Results: Completion rates at baseline were ≥90% in each group and scores were well balanced. Crizotinib treatment was associated with a significantly longer TTD compared with PEM (median, 5.6 vs. 1.9 mo; HR, 0.66; 95% CI, 0.48−0.92; P=0.013) or DOC (median, 5.6 vs. 0.9 mo; HR, 0.37; 95% CI, 0.26−0.54; P<0.0001). A significantly greater improvement from baseline was observed with crizotinib compared with either the PEM or DOC subgroups for global QOL (P<0.01), cough (P<0.001), dyspnea (P<0.0001), pain in arm or shoulder (P<0.0001), pain in chest (P<0.0001), pain in other parts (P<0.01), fatigue (P<0.05), insomnia (P<0.05), and pain (P<0.0001). A significantly greater improvement was also observed with crizotinib compared with DOC for functioning (P<0.05), alopecia (P<0.0001), and hemoptysis (P<0.0001). Conclusions: Crizotinib treatment showed a significantly greater improvement from baseline in key patient-reported lung cancer symptoms and global QOL compared with DOC and PEM, in addition to improved efficacy previously reported. Clinical trial information: NCT00932893.

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Xu, Fengqin, Liang Ma, Yinhe Wang, Jiang Yu, Dandan Li, Guohui Zhou, Yuzi Xu, Hailin Zhang, and Yang Cao. "Effects of an Innovative Training Program for New Graduate Registered Nurses: A Comparison Study." SAGE Open 11, no. 1 (January 2021): 215824402098854. http://dx.doi.org/10.1177/2158244020988542.

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New graduate registered nurses (NGRNs) face a great challenge during the transition from school to clinical practice. We conducted a quasi-randomized controlled study to evaluate the effects of a new training mode for newly recruited NGRNs in a Chinese teaching hospital. A total of 150 NGRNs were recruited from a teaching hospital and assigned into two groups. The conventional training and a new training program were taken for the control group and the research group, respectively. At the end of the training, the two groups were evaluated and compared for theoretical knowledge and operation skills using a mutual-evaluation examination and the Chinese Registered Nurse Core Competency Scale. The scores of theoretical knowledge (88.4 vs. 81.7, p < .001) and operation skills (94.8 vs. 90.3, p < .001), and the total core competencies score (156.2 vs. 148.8, p < .05) in the research group were statistically significantly higher than those in the control group. Compared with the control group, the research group also had statistically significantly higher scores in education and consultation (2.47 vs. 2.40), clinical nursing (2.87 vs. 2.62), interpersonal relationship (2.56 vs. 2.43), and critical thinking and scientific research (2.78 vs. 2.61). The innovative pre-job training program for NGRNs conducted in Chinese clinical nursing skill training bases might significantly improve the training effects and is worthy of broader implementation.

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Sookoian, S., G. Castaño, B. Frider, P. Viudez, and D. Flichman. "Efficacy of 3 MU vs. 5 MU of interferon alpha induction therapy innaive patients with chronic hepatitis C." Journal of Hepatology 32 (2000): 196. http://dx.doi.org/10.1016/s0168-8278(00)81078-8.

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Cuesta, Eva, and Jorge M. Lobo. "Visible and near-infrared radiation may be transmitted or absorbed differently by beetle elytra according to habitat preference." PeerJ 7 (November 25, 2019): e8104. http://dx.doi.org/10.7717/peerj.8104.

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Background The exoskeleton of an insect could be an important factor in the success of its evolutionary process. This reaches its maximum expression in beetles, which constitute the most diversified animal taxon. The involvement in the management of environmental radiation could be one of the most important functions of the exoskeleton due to the passive contributions to the thermoregulation of body temperature. We study whether the elytra of two sympatric and closely related beetle species respond differentially to the radiation of distinct wavelengths in agreement with their ecological preferences. Methods Onthophagus coenobita (Herbst) and O. medius (Kugelaan) occupy different habitats and environmental conditions (shaded vs. unshaded from solar radiation). The potential adaptive variations to thermoregulation under these different ecological conditions were studied using the responses of their exoskeletons to radiation of different wavelengths (ultraviolet, visible and near-infrared). For these two species, the amounts of the three wavelengths that were reflected, transmitted or absorbed by the exoskeleton were measured using of a spectrophotometer. In addition, the darkness and thickness of the elytra were examined to determine whether these two features influence the management of radiation by the exoskeleton. Results Both species differ in the management of visible and near-infrared radiation. In agreement with habitat preferences, the species inhabiting shaded conditions would allow infrared and visible radiation to penetrate the elytra more easily to heat internal body parts, while the elytra of the heliophilous species would have increased absorbance of these same types of radiation. An increase in body size (and therefore in elytron thickness) and the quantity of dark spots may serve as barriers against exogenous heat gain. However, the maintenance of between-species differences independent of the effects of these two morphological features led us to suspect that an unconsidered elytron characteristic may also be affecting these differences. Discussion The results of the involvement of the exoskeleton thickness and spots in the thermoregulation of insects opens new research lines to obtain a better understanding of the function of the exoskeleton as a passive thermoregulation mechanism in Coleoptera.

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Molino, A., M. Pavarana, R. Micciolo, P. Castiglioni, and G. L. Cetto. "Comparison of clinical, biological and pathological characteristics in symptomatic vs asymptomatic breast cancers (BC): study of 1969 patients (pts)." European Journal of Cancer 35 (September 1999): S201. http://dx.doi.org/10.1016/s0959-8049(99)81207-6.

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Yu, De-Yi, Hung-Chang Chen, Shu-Ying Chang, Yen-Chang Hsiao, and Cheng-Jen Chang. "Comparing the Effectiveness of 1064 vs. 810 nm Wavelength Endovascular Laser for Chronic Venous Insufficiency (Varicose Veins)." LASER THERAPY 22, no. 4 (2013): 247–53. http://dx.doi.org/10.5978/islsm.13-or-19.

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Tian, Lan, Jingxuan Wang, Ying Wei, Jianren Lu, Anting Xu, and Ming Xia. "Short-wavelength infrared laser activates the auditory neurons: comparing the effect of 980 vs. 810 nm wavelength." Lasers in Medical Science 32, no. 2 (December 16, 2016): 357–62. http://dx.doi.org/10.1007/s10103-016-2123-4.

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Li, Wei Fen, Wei Niu, Zhi Ming Hao, and Ming Hai Li. "The Effect of Temperature on the Tensile Properties of Steel 0Cr18Ni9." Materials Science Forum 654-656 (June 2010): 194–97. http://dx.doi.org/10.4028/www.scientific.net/msf.654-656.194.

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Experiments of tensile mechanical properties of steel 0Cr18Ni9 are done on the MTS 810 tensile testing machine, and the temperature range is from 20°C to 1200°C. The stress vs. strain curves are obtained. Results show that the elastic modulus, yield stress and tensile strength decrease with increasing temperature .Based on the experiment results, the functions of the elastic modulus, yield strength and tensile strength versus temperature are represented by polynomial.

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Luzier, Aileen B., Laura A. Antell, Li-Ling Chang, Jianwei Xuan, and David A. Roth. "Reimbursement Claims Analysis of Outcomes with Carvedilol and Metoprolol." Annals of Pharmacotherapy 36, no. 3 (March 2002): 386–91. http://dx.doi.org/10.1345/aph.1a146.

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OBJECTIVE: To compare resource use and costs in heart failure (HF) patients receiving metoprolol, a selective β1-receptor blocker, with carvedilol, which blocks β1-, β2-, and α1-adrenergic receptors, by use of a retrospective reimbursement—claims analysis. METHODS: Resource use and cost data were extracted for patients diagnosed with HF and treated with carvedilol or metoprolol for 6 months after the initiation of the respective therapy, by use of claims submitted to 6 healthcare plans. A modified Charlson index was used to assess comorbidity. Stepwise logistic regression was used to measure the influence of treatment on hospitalization. RESULTS: Claims from 139 carvedilol and 106 metoprolol patients showed that carvedilol patients experienced significantly fewer total hospitalizations (36.0% vs. 62.3%, respectively; p < 0.001) and emergency department visits (23.7% vs. 42.5%, respectively; p = 0.002) and a trend for fewer HF—related (7.9% vs. 14.2%, respectively; NS) and cardiac-related hospitalizations (15.1% vs. 24.5%, respectively; NS). Treatment with carvedilol was associated with a significant decrease in the risk of any hospitalization (adjusted odds ratio 0.35, 95% CI 0.20 to 0.63; p < 0.001). Higher pharmacy costs (mean $1677 vs. $1322; p < 0.001) and lower total costs (mean $8100 vs. $14 475; p = 0.025) were observed in carvedilol-treated compared with metoprolol-treated patients, respectively. CONCLUSIONS: Compared with metoprolol, the more comprehensive adrenergic blockade achieved with carvedilol may translate into greater clinical benefits in patients with HF. Despite higher pharmacy costs, lower total costs were observed in carvedilol-treated patients.

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Kim, Kyu Nam, Mi Ae Jeong, You Na Oh, Soo Yeon Kim, and Ji Yoon Kim. "Efficacy of Pentax airway scope versus Macintosh laryngoscope when used by novice personnel: A prospective randomized controlled study." Journal of International Medical Research 46, no. 1 (August 23, 2017): 258–71. http://dx.doi.org/10.1177/0300060517726229.

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Objective To determine whether intubation education using the Pentax Airway Scope (AWS) in normal airways is more useful than direct laryngoscopy (Macintosh laryngoscope) in novice personnel. Methods Eleven intern doctors without intubation experience performed 60 sequential intubations with each device on a manikin and 10 sequential intubations in adult patients. The time required for successful intubation, percentage of glottic opening (POGO) score, number of intubation attempts, and number of dental injuries were analyzed for each intubation technique. Results The mean (standard deviation) time required for successful intubation decreased as the number of intubations increased and was significantly shorter with the Pentax AWS than direct laryngoscope [22.6 (7.3) vs. 29.6 (10.0) and 33.0 (8.0) vs. 44.7 (5.6) s, respectively] in both the manikin and clinical studies. The Pentax AWS was also associated with higher POGO scores than the direct laryngoscope [81.7 (8.9) vs. 55.1 (13.2) and 80.9 (9.7) vs. 49.6 (16.5), respectively] and fewer intubation attempts. Fewer dental injuries occurred with the Pentax AWS in the manikin study. Conclusions Novices performed intubation more rapidly and easily with an improved laryngeal view using the Pentax AWS. We suggest that intubation education with video laryngoscopy should be mandatory along with direct laryngoscope training.

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Ramirez-Barba, E. J., M. Di Silvio, M. Dibildox, A. Moguel, F. Rodriguez, I. Almaguer, P. Andrade, R. Fischer, M. Klein, and W. Wurst. "Superiority of 20MG pantoprazole (PANTO) VS 150mg×2 ranitidine (RANI) in healing and symptom relief of patients with mild reflux esophagitis." Gastroenterology 114 (April 1998): A264. http://dx.doi.org/10.1016/s0016-5085(98)81075-5.

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Schmitz-Rixen, T., M. Steffen, D. Böckler, and R. T. Grundmann. "Offene und endovaskuläre Versorgung des infrarenalen vs. juxtarenalen Bauchaortenaneurysmas." Gefässchirurgie 25, no. 7 (August 24, 2020): 568–74. http://dx.doi.org/10.1007/s00772-020-00681-w.

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Zusammenfassung Hintergrund und Zielsetzung Die vorliegende Untersuchung geht der Frage nach, wie sich die perioperativen Ergebnisse bei elektiver Versorgung juxtarenaler abdomineller Aortenaneurysmen (AAA) von denen bei Versorgung infrarenaler AAA unterscheiden. Material und Methoden Datenbasis ist das AAA-Register des Deutschen Instituts für Gefäßmedizinische Gesundheitsforschung (DIGG) der Deutschen Gesellschaft für Gefäßchirurgie und Gefäßmedizin (DGG) der Jahre 2013–2017 mit insgesamt 18.629 Patienten, 17.026 (91,4 %) mit infrarenalem und 1603 (8,6 %) mit juxtarenalem AAA. Bei den infrarenalen AAA wurden 80,5 % (n = 13.707) endovaskulär (EVAR) und 3319 (19,5 %) offen (OAR) versorgt, bei den juxtarenalen waren es 786 Patienten mit EVAR (49,0 %) und 817 (51,0 %) mit OAR. Ergebnisse Sowohl bei OAR als auch bei EVAR waren Patienten mit juxtarenalen AAA in ihren Ausgangsbedingungen nicht mit Patienten mit infrarenalen AAA vergleichbar. Der Frauenanteil war bei juxtarenalen AAA signifikant höher (bei EVAR 16,9 % vs. 13,1 %, bei OAR 18,6 % vs. 16,0 %) und der Aneurysmadurchmesser war signifikant größer (bei EVAR 57,8 vs. 54,3 mm, bei OAR 59,0 vs. 56,3 mm). Patienten mit juxtarenalem AAA zeigten signifikant häufiger als Patienten mit infrarenalem AAA bereits präoperativ eine eingeschränkte Nierenfunktion (12,5 % vs. 9,7 % bei EVAR, 14,4 % vs. 9,4 % bei OAR). Die Klinikletalität betrug bei EVAR 1,0 % (infrarenale AAA) vs. 5,7 % (juxtarenale AAA) (p = 0,000), bei OAR 4,2 % (infrarenale AAA) vs. 7,7 % (juxtarenale AAA) (p = 0,000). Zu einer postoperativen Verschlechterung der Nierenfunktion kam es bei EVAR in 2,0 % der Fälle mit infrarenalen AAA vs. 12,2 % bei juxtarenalen AAA (p = 0,000), bei OAR in 7,9 % vs. 19,5 % (p = 0,000). Schlussfolgerungen Im vorliegenden Krankengut waren die Raten an postoperativen Komplikationen sowie die postoperative Sterblichkeit bei Versorgung juxtarenaler AAA signifikant höher als bei Versorgung infrarenaler AAA, das galt sowohl für EVAR als auch für OAR. Inwieweit dies an den ungünstigeren Ausgangsbedingungen bei Patienten mit juxtarenalen AAA lag und welche Rolle die gewählte Operationstechnik dabei spielte, sollte in weiteren Erhebungen überprüft werden.

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Wang, Alice S., Jessica K. Campos, Geoffrey P. Colby, Alexander L. Coon, and Li-Mei Lin. "Cerebral aneurysm treatment trends in National Inpatient Sample 2007–2016: endovascular therapies favored over surgery." Journal of NeuroInterventional Surgery 12, no. 10 (March 18, 2020): 957–63. http://dx.doi.org/10.1136/neurintsurg-2019-015702.

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BackgroundFlow modulation is the newest endovascular technique for treatment of cerebral aneurysms.ObjectiveTo investigate changes in aneurysm treatment practice patterns in the USA.MethodsFrom the 2007 to 2016, the National Inpatient Sample databases, hospital discharges associated with unruptured aneurysms (UA), and/or ruptured aneurysms (RA) having undergone surgical clipping (SC) and/or endovascular treatments (EVT) were identified using the International Classification of Diseases codes. Patient demographics, hospital characteristics, and clinical outcomes were reviewed. Five year subgroup analyses were performed for treatment differences.ResultsA total of 39 282 hospital discharges were identified with a significant increase in EVT (UA: SC n=7847 vs EVT n=12 797, p<0.001; RA: SC n=8108 vs EVT n=10 530, p<0.001). Hospitals in the South demonstrated the most significant EVT use regardless of aneurysm status (UA: SC n=258.5±53.6 vs EVT n=480.7±155.8, p<0.001; RA: SC n=285.6±54.3 vs EVT n=393.3±102.9, p=0.003). From 2007 to 2011, there was no significant difference in the mean number of cases for the treatment modalities (UA: SC n=847.4±107.7 vs EVT n=1120.4±254.1, p=0.21; RA: SC n=949.4±52.8 vs EVT n=1054.4±219.6, p=0.85). Comparatively, from 2012 to 2016, significantly more UA and RA were treated endovascularly (UA: SC n=722.0±43.4 vs EVT n=1439.0±419.2, p<0.001; RA: SC n=672.2±61.4 vs EVT n=1051.6±330.2, p=0.02).ConclusionsAs technological innovations continue to advance the neuroendovascular space, the standard of care for treatment of cerebral aneurysms is shifting further towards endovascular therapies over open surgical approaches in the USA.

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Rass, K. "Crossektomie und Stripping vs. endothermische Ablation der V. saphena magna: Was können wir aus aktuellen Langzeitanalysen lernen?" Phlebologie 47, no. 05 (August 2018): 265–71. http://dx.doi.org/10.12687/phleb2436-5-2018.

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ZusammenfassungHintergrund: Die Therapie der Stammvarikose erfolgt weltweit mit unterschiedlicher Präferenz endovenös, überwiegend thermoablativ, oder offen-chirurgisch. Aktuell liegt jedoch eine Evidenz aus Langzeitstudien (Nachbeobachtungszeit ≥ 5 Jahre) vor, die eine erneute Betrachtung der Wertigkeit der Therapieverfahren notwendig macht. Methoden: Systematische Literaturrecherche zu Langzeitstudien, in denen endovenös thermische Ablationsverfahren mit Crossektomie und Stripping der V. saphena magna verglichen werden. Deskriptive Auswertung der Ergebnisse. Ergebnisse: Langzeitstudien liegen nahezu ausschließlich für den Vergleich mit endovenöser Laserablation und Lichtwellenleitern der 1. Generation (810–980 nm) vor. Während hinsichtlich der Krankheitsschwere und der postoperativen Lebensqualität keine Unterschiede zu beobachten sind, ist die Rate duplexsonographischer und klinischer Crossenrezidive nach Crossektomie signifikant geringer. Schlussfolgerungen: Valide Langzeitstudien zu den heute überwiegend verwendeten endothermischen Ablationstechniken im Vergleich zur offenen Operation fehlen, sind aber angesichts der Befunde aus Studien mit Lasern der 1. Generation dringend geboten.

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Scorolli, Lucia, Daniele Corazza, Mariachiara Morara, Sabrina Vismara, Maria Luisa Lugaresi, and Renato Alberto Meduri. "Argon laser vs. subthreshold infrared (810-nm) diode laser macular grid photocoagulation in nonexudative age-related macular degeneration." Canadian Journal of Ophthalmology 38, no. 6 (October 2003): 489–95. http://dx.doi.org/10.1016/s0008-4182(03)80028-5.

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Navarro G, Usmaila S., Mónica A. Ladino D., Luis Jorge Morales R., and Leonardo E. Ordóñez-Ordóñez. "Tratamiento endoscópico en pacientes con estenosis subglótica." ACTA DE OTORRINOLARINGOLOGÍA & CIRUGÍA DE CABEZA Y CUELLO 40, no. 2 (August 31, 2018): 114–19. http://dx.doi.org/10.37076/acorl.v40i2.223.

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Objetivos: Determinar cuáles son los tipos de estenosis subglótica que pueden ser manejados por vía endoscópica. Diseño: Estudio observacional, descriptivo, tipo serie de casos. Métodos: La medición principal es el éxito/fracaso con el manejo endoscópico. Se tomaron 83 pacientes con estenosis subglótica, con manejo endoscópico; la información fue completa en 65 casos. La edad media fue de 22,3 años, 53 hombres y 12 mujeres; 40 tuvieron estenosis simples, 25 complejas. Resultados: No hubo asociación manifiesta entre el éxito y el procedimiento endoscópico, la edad y la localización de la estenosis. Hubo diferencias significativas entre la medición principal (éxito/fracaso) y las variables de porcentaje de estenosis (61,1% vs. 81,7%), longitud de la estenosis (1,1 cm vs. 2,2 cm), sitio comprometido (simples-éxito = 80%, complejas-éxito = 25%) y consistencia (blanda-éxito = 86%, dura-éxito = 44%). Conclusiones: Los procedimientos endoscópicos tienden a ser exitosos en estenosis simples, blandas, con porcentajes de estenosis ≤ 62% y longitud de la estenosis ≤ 1,1 cm.

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Journal articles on the topic 'VS 8107'

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