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Dissertations / Theses on the topic 'Vulvar cancer in situ'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

Madeleine, Margaret M. "Three case-control studies : vulvar cancer, invasive cervical cancer, and in situ adenocarcinoma of the cervix /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/10895.

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2

LEFEUVRE, BRIGITTE. "Le traitement par le laser co2 des lesions de la vulve : a propos de 79 observations." Nantes, 1988. http://www.theses.fr/1988NANT025M.

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3

黃鳳如 and Fung-yu Huang. "Molecular and cytogenetic analysis of cervical and vulvar cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B26662188.

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4

MALBERTI, SILVIA. "Carcinoma della vulva recidivo dopo chirurgia o localmente avanzato: ruolo e possibilità di chemioterapia neoadiuvante." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2011. http://hdl.handle.net/10281/28328.

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Background: no standard treatment are avaliable for patients with locally advanced or recurrent vulvar cancer Patients and Methods:35 patients with recurrent and 26 patients with locally advanced vulvar cancer received paclitaxel/cisplatin and or without ifosfamide every 3 weeks for up to 6 cycles. Primary objective was response rate and operability rate. Secondary objective were response duration and toxicity. Response evaluation was assessed by WHO criteria; tossicity according to common toxicity criteria. Results: Sixty-one women were included with a median age of 75 (range 43-85). On st

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5

Murray, Abner A. "Plant Virus Nanoparticle In Situ Cancer Immunotherapies." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1532370850718292.

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6

UZAN, ERIC. "Les carcinomes mammaires in situ." Amiens, 1992. http://www.theses.fr/1992AMIEM089.

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7

Makkouk, Amani Riad. "Biodegradable microparticles for in situ immunization against cancer." Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/1484.

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Cancer immunotherapy has proven to be challenging as it depends on overcoming multiple mechanisms that mediate immune tolerance to self-antigens. In situ immunization is based on the concept that it is possible to break immune tolerance by inducing tumor cell death in situ in a manner that provides antigen presenting cells such as dendritic cells (DCs) with a wide selection of tumor antigens that can then be presented to the immune system and result in a therapeutic anticancer immune response. Based on recent advances in the understanding of antitumor immunity, we designed a three-step approac

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8

Hussain, Shehnaz Khursheed. "Genetic variation in immune regulatory cytokine genes, cigarette smoking, and human papillomavirus-associated cancer risk /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/10940.

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9

Линдін, Микола Сергійович, Николай Сергеевич Лындин, Mykola Serhiiovych Lyndin, et al. "Prognostic value of CEACAM1 in breast cancer in situ." Thesis, Springer, 2019. http://essuir.sumdu.edu.ua/handle/123456789/75201.

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Background & Objectives: Ductal breast cancer can be divided into invasive and non-invasive types (cancer in situ – DCIS). Although there is information about molecular features of these tumours, DCIS remains none fully described pathology. Thus we need to find novel reliable diagnostic markers. One could be the сarcinoembryonic antigen related cell adhesion molecules 1 (CEACAM1). This molecule was described in diverse invasive types of cancers. The aim our study presented here was to characterise the exact expression pattern of CEACAM1 in various types of DCIS.

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10

Guimaraes-Young, Amy. "Gynecological tissue homeostasis and tumorigenesis studies using mouse models." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5942.

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Gynecological cancers present a tremendous disease burden worldwide. Endometrial cancer, the most common gynecological malignancy, is predominantly a disease of deranged glandular function. The mechanisms by which known environmental risk factors influence the mutational profile of endometrial cancer are poorly understood. Non-HPV vulvar cancer, on the other hand, is a very rare gynecological malignancy of vulvar squamous cells with little known about its pathogenesis. Surgical resection of vulvar cancer is associated with high post-surgical morbidity. Pivotal to improving treatment and outcom

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11

Webster, Lucy R. "Diagnostic molecular profiling of ductal carcinoma in situ of the breast." Thesis, The University of Sydney, 2007. https://hdl.handle.net/2123/28109.

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The introduction of population-based mammographic screening has led to a dramatic increase in the diagnosis of ductal carcinoma in situ (DCIS) of the breast; with DCIS now accounting for approximately 25-35% of all screen-detected breast cancers. Epidemiological, histopathological and molecular studies have provided compelling evidence to support the notion that DCIS is a direct precursor of invasive cancer; although such data also indicate that DCIS represents a highly heterogeneous group of lesions. Some women with DCIS will develop life-threatening invasive cancer, whereas others may

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12

Kiflemariam, Sara. "Expression and Mutation Analyses of Candidate Cancer Genes In Situ." Doctoral thesis, Uppsala universitet, Institutionen för immunologi, genetik och patologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-184510.

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Cancers display heterogeneity in genetic profiles of the individual cancer cells and in the composition of different malignant and non-malignant cell populations. Such intra-tumor heterogeneity plays a role in treatment response and the emergence of resistance to cancer therapies. Approaches that address this complexity and improve stratification of patients for treatment are therefore highly warranted. Thus, the aims of this thesis were to further develop and apply in situ technologies for expression and mutation analyses of candidate cancer genes to gain a deeper understanding of cancer biol

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13

Petridis, Christos. "Molecular genetics of lobular breast cancer ductal carcinoma in situ." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/molecular-genetics-of-lobular-breast-cancer-ductal-carcinoma-in-situ(788866a0-2bd3-4fa7-82b0-4135f4823d1a).html.

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Ductal carcinoma in situ (DCIS) and lobular carcinoma in situ (LCIS) are clinically undetectable forms of non-invasive breast cancer. DCIS is considered a non-obligate precursor of invasive ductal carcinoma (IDC). LCIS shares many of the same genetic aberrations as invasive lobular breast cancer (ILC), which accounts for 10-15% of all invasive breast cancer. With the advent of screening mammography, the diagnosis of pure DCIS (with no invasive component) and LCIS has become more common, and approximately 20% of screen detected tumours are pure DCIS. The aim of this project is to test the hypot

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14

Mannu, Gurdeep Singh. "Epidemiology of ductal carcinoma in situ." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:c78ce9f9-b5f6-4166-a53e-5d79819c7a28.

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<b>Introduction:</b> Almost 7,000 people are diagnosed with ductal carcinoma in situ (DCIS) in the United Kingdom each year, but there remains uncertainty regarding its natural history and optimal management. The aim of this thesis was to evaluate factors contributing to the epidemiology of DCIS and its outcomes. <b>Methods:</b> 1) A cohort study comparing risk factors for DCIS and invasive breast cancer (IBC) using UK Biobank; 2) A cohort study examining the accuracy of preoperative biopsy in DCIS using clinical records from the Netherlands Cancer Institute; 3) A cohort study examining the ra

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15

Gusmão, Lívia Fernandes Sampaio. "Análise da presença de metilação dos genes P16INK4a e TIMP-2 em pacientes com líquen escleroso vulvar." Niterói, 2013. https://app.uff.br/riuff/handle/1/4733.

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Submitted by Ana Lúcia Torres (bfmhuap@gmail.com) on 2017-09-29T15:10:17Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertação Livia Gusmao.pdf: 1628245 bytes, checksum: 42849e5f87bd042f59660a228ded7164 (MD5)<br>Approved for entry into archive by Ana Lúcia Torres (bfmhuap@gmail.com) on 2017-09-29T15:10:28Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertação Livia Gusmao.pdf: 1628245 bytes, checksum: 42849e5f87bd042f59660a228ded7164 (MD5)<br>Made available in DSpace on 2017-09-29T15

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16

Chatelain, Clément. "Morphogenèse du mélanome in situ." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2012. http://tel.archives-ouvertes.fr/tel-00794989.

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Le mélanome est le cancer de la peau le plus mortel. S'il est détecté de manière précoce il peut cependant être traité par simple excision et les chances de guérison sont alors très bonnes. Des algorithmes de diagnostic différentiels basés sur des critères morphologiques permettent ainsi de distinguer cette tumeur d'autres lésions bénignes présentes à la surface de la peau. Les mécanismes engendrant les formes et les microstructures caractéristiques d'un mélanome restent cependant pratiquement inconnus. L'objectif de ce travail est d'éclairer les processus morphogénétiques à l'oeuvre lors du d

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17

Hammond, David William. "Analysis of non-Hodgkin's lymphoma by conventional cytogenetics and fluorescence in-situ hybridisation." Thesis, University of Sheffield, 1995. http://etheses.whiterose.ac.uk/3064/.

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Cytogenetic analysis was performed on 40 non-Hodgkin's lymphoma (NHQ node biopsies. Chromosomes X, 3 and 12 were the most frequently gained; of the much rarer monosomies, loss of chromosome 13 was most common. Structural abnormalities primarily involved chromosomes 14,1,18,6 and 17. A markedly greater number of chromosome gains were associated with low-grade disease when compared to high-grade. In order to obtain further information from the cytogenetic analysis of the NHL karyotypes, the fluorescence in-situ hybridisation (FISH) technique was applied to the series. The activation state of add

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18

Herrington, Charles Simon. "In situ analysis of human papillomaviruses and chromosome aberrations in cervical neoplasia." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279806.

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19

Löf, Liza. "Applications of in situ proximity ligation assays for cancer research and diagnostics." Doctoral thesis, Uppsala universitet, Molekylära verktyg, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-300191.

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In the field of cancer research and diagnostics it is crucial to have reliable methods for detecting molecules involved in the disease. New and better methods for diagnostics, prognostics and drug delivery therefore remain a permanent aim. In this thesis applications of the in situ proximity ligation assay (in situ PLA) were developed for diagnostics and research. Two new methods were developed, one more cost effective proximity assay without the use of enzymes and one method for loading pharmaceuticals in lipid rafts made from detergent resistant membranes (DRMs) to be used as a drug delivery

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20

PINEAUD, BEATRICE. "Les carcinomes intracanalaires du sein (cancers in situ) : a propos de 50 cas." Aix-Marseille 2, 1988. http://www.theses.fr/1988AIX20032.

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21

Verrons, Pierre. "Les carcinomes canalaires in situ du sein pris en charge à l'Institut Bergonié de 1963 à 1993, étude rétrospective de 353 cas." Bordeaux 2, 1996. http://www.theses.fr/1996BOR2M114.

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22

Fonseca, Tatiane Ribeiro da. "DETECÇÃO E GENOTIPAGEM DE HPV EM CARCINOMAS DE VULVA E DE VAGINA." Pontifícia Universidade Católica de Goiás, 2014. http://localhost:8080/tede/handle/tede/2386.

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Made available in DSpace on 2016-08-10T10:38:52Z (GMT). No. of bitstreams: 1 Tatiane Ribeiro da Fonseca.pdf: 3044117 bytes, checksum: d604b5b291d33d0e053ad75336e7a264 (MD5) Previous issue date: 2014-06-26<br>This study evaluated the sociodemographic and clinicopathological aspects of patients with cancer of the vulva and the vagina diagnosed in Araújo Jorge Hospital, Goiânia - GO as well as the prevalence of HPV and HPV16 and 18 genotypes in these tumors. The sample consisted of paraffin embedded samples from 57 patients with primary invasive vulvar cancer and 20 patients with primary invasi

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23

Luk, Tat-fai Samuel, and 陸達輝. "HER2 status in gastric cancer : a pilot study using silver in situ hybridization." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206550.

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Gastric cancer is one of the worldwide leading cancers which is highly prevalent in Eastern Asia. In Hong Kong, there were 1101 new cases and 687 cancer death in year 2011. So far gastric cancer is known to have poor prognosis and high relapse rate, for which a more effective therapy is sorely needed. With increasing knowledge in the role of HER2 in gastric cancer, a novel targeting agent, Trastuzumab, in combination with chemotherapy has become a promising personalized therapy for advanced gastric cancer and gastro-oesophageal junction cancer patients, particularly effective in HER2 positive

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24

Kawashita, Masakazu. "Preparation of Glasses for In Situ Radiotherapy of Cancer by P[+] Ion Implantation." Kyoto University, 1998. http://hdl.handle.net/2433/77864.

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25

LEPHAY, MANSARD CHRISTINE. "Epidemiologie du cancer in situ du col uterin : a propos de 110 cas." Amiens, 1988. http://www.theses.fr/1988AMIEM061.

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26

Fiche, Maryse. "Apport des methodes d'hybridation in situ fluorescente et d'immunohistochimie a l'etude des carcinomes canalaires in situ et des carcinomes mammaires invasifs des femmes jeunes (doctorat : biologie moleculaire et cellulaire)." Nantes, 2000. http://www.theses.fr/2000NANT18VS.

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27

Calvary, Ronan. "Les tumeurs bilatérales consécutives du testicule : à propos de 7 observations, réflexions sur le carcinome in situ." Bordeaux 2, 1996. http://www.theses.fr/1996BOR2M093.

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28

Szeto, Elaine. "Evaluation of fluorescence in situ hybridization (FISH) as a tool for screening of bladder cancer." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42904377.

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29

Zhou, Wenjing. "Aspects of Progression in Breast Carcinoma : from ductal carcinoma in situ to invasive cancer." Doctoral thesis, Uppsala universitet, Institutionen för kirurgiska vetenskaper, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-166745.

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In the past decades our knowledge concerning breast cancer progression from ductal carcinoma in situ (DCIS) to invasive cancer has grown rapidly. However, molecular factors driving the progression are still largely unknown. In the first study, we investigated tumor evolution in breast cancer by analyzing TP53 mutation status in tumors from various stages of the disease. Presence of the same TP53 mutations in both DCIS and invasive components from the same tumor indicates same cellular origin. The role of mutant TP53 in the progression of breast cancer is less clear and may vary between subtype

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30

Camacho, Moll Maria Elena. "Germ cell neoplasia in situ (GCNIS) and the pathogenesis of testicular germ cell cancer." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28807.

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Testicular germ cell cancer (TGCC) has been increasing in incidence over recent decades, and is currently the most common malignancy amongst young men resulting in significant morbidity. These tumours are believed to arise from premalignant germ cell neoplasia in situ (GCNIS) cells, which originate from the aberrant germ cell differentiation from gonocyte to spermatogonia during fetal/early postnatal life. GCNIS cells remain dormant in the testis until puberty when they are activated to become tumours. Therefore, GCNIS cells remain in a pre-invasive stage during early childhood and early adult

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31

Pandey, Puspa Raj. "ROLES OF LIPOGENESIS IN BREAST CANCER PROGRESSION." OpenSIUC, 2012. https://opensiuc.lib.siu.edu/dissertations/490.

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Elevated level of lipogenic enzymes and overall lipogenesis have been reported in a wide variety of cancers and blocking the lipogenic pathway by chemical inhibitors or RNA interference causes tumor cell death by apoptosis which provides a strong rationale for targeting lipogenic pathway for the treatment and prevention of cancer however the exact role of lipogenesis as a cause, facilitator or consequence is not yet clearly understood. Therefore in this dissertation research, we set up to determine the mechanism of tumor cell death by inhibiting lipogenesis and to determine the role of increas

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32

PATRY, LUBETH MARIE-FRANCOISE. "Les carcinomes intragalactophoriques du sein : a propos de 108 cas." Lille 2, 1992. http://www.theses.fr/1992LIL2M124.

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33

Lopez, Mercédès. "Les adénocarcinomes in-situ du col utérin : à propos de 3 cas." Montpellier 1, 1993. http://www.theses.fr/1993MON11086.

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34

Ashok, Mahima. "Analysis of HER2 testing in breast cancer." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/29711.

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Thesis (Ph.D)--Biomedical Engineering, Georgia Institute of Technology, 2010.<br>Committee Chair: Griffin, Paul; Committee Member: Butera, Robert; Committee Member: Halpern, Michael; Committee Member: Nichols, Richard; Committee Member: Vidakovic, Brani. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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35

司徒柏沂 and Elaine Szeto. "Evaluation of fluorescence in situ hybridization (FISH) as a tool for screening of bladder cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42904377.

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36

Machado, Flávio Amorim [UNESP]. "Avaliação da densidade vascular pelo CD-34 no carcimona ductal in situ da mama comparando os tipos comedo e não comedo." Universidade Estadual Paulista (UNESP), 2006. http://hdl.handle.net/11449/93102.

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Made available in DSpace on 2014-06-11T19:26:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-12-18Bitstream added on 2014-06-13T20:15:07Z : No. of bitstreams: 1 machado_fa_me_botfm_prot.pdf: 1024522 bytes, checksum: 6a04be77f915f82408a3f436644f9ffa (MD5)<br>Fundação para o Desenvolvimento Médico e Hospitalar (Famesp)<br>Em nosso estudo avaliamos a densidade vascular pelo CD-34 no carcinoma ductal in situ da mama comparando os tipos comedo e não comedo. Foram selecionados 52 casos de CDIS divididos em dois grupos, segundo o tipo histológico. Grupo A: 30 casos tipo comedo e Grupo B:

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37

Machado, Flávio Amorim. "Avaliação da densidade vascular pelo CD-34 no carcimona ductal in situ da mama comparando os tipos comedo e não comedo /." Botucatu : [s.n.], 2006. http://hdl.handle.net/11449/93102.

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Orientador: José Ricardo P. Rodrigues<br>Banca: José Ricardo P. Rodrigues<br>Banca: Gilberto Uemura<br>Banca: César Cabello dos Santos<br>Resumo: Em nosso estudo avaliamos a densidade vascular pelo CD-34 no carcinoma ductal in situ da mama comparando os tipos comedo e não comedo. Foram selecionados 52 casos de CDIS divididos em dois grupos, segundo o tipo histológico. Grupo A: 30 casos tipo comedo e Grupo B: 22 casos tipo não comedo. Os subtipos histológicos encontrados no grupo B foram: cribriforme, papilífero, sólido e micropapilífero. A média de idade do grupo A foi de 52,7 e de 61,9 para o

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38

Silhol-Navarro, Christine. "Reconstruction mammaire immédiate après mastectomie pour carcinome in situ : satisfaction ou déception." Montpellier 1, 1992. http://www.theses.fr/1992MON11121.

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39

Oduwole, O. (Olayiwola). "17β-hydroxysteroid dehydrogenase types 1 and 2 in human normal and malignant breast and gastrointestinal tract". Doctoral thesis, University of Oulu, 2003. http://urn.fi/urn:isbn:9514270746.

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Abstract 17β-hydroxysteroid dehydrogenases (17HSDs) catalyze the interconversion of high-activity 17β-hydroxysteroids and low-activity 17-ketosteroids. In the present study, the mRNA of the 17HSD type 1 and 2 enzymes, catalyzing opposite reactions of estrogen metabolism, was analyzed in normal and malignant breast and gastrointestinal tract by in situ hybridization. Further, the activities of these enzymes were measured in normal and adenomatous intestinal cell lines. Markers of the main mesenchymal cell types were also used to study the cell-type specific expression of the 17HSD type 2 enzym

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40

Raibaut, Xavier. "Le diagnostic du carcinome canalaire in situ du sein en 1990 : données de l'imagerie et corrélations radio-histologiqes : à propos d'un cas." Montpellier 1, 1990. http://www.theses.fr/1990MON11210.

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41

Tiffet, Olivier. "Caracteristiques et etude des facteurs pronostics des carcinomes canalaires infiltrants avec in situ predominant du sein : a propos de 37 cas." Lille 2, 1992. http://www.theses.fr/1992LIL2M278.

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42

Kaira, Mustapha. "In situ molecular profilling of the microenvironment of breast carcinoma." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-265258.

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High stromal PDGF receptor B expression was shown to have strong prognostic value in a studyinvolving over 600 breast cancer patients however, the molecular role of the receptor in tumordevelopment remains unclear. In this project we studied the spatial distribution and expressionlevels of a panel genes and markers associated with PDGF signaling, in breast cancer tumormicroenvironment (TME) using a newly developed technique -in situ sequencing. The techniquerelies on padlock probes which we validated with corresponding RNA sequencing, microarray,and immunohistochemistry data. Our results showe

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43

DANHIEZ, CHRISTOPHE. "Conisation laser : a propos de 62 cas." Reims, 1992. http://www.theses.fr/1992REIMM054.

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44

Carrera, Cristina. "Ductal carcinoma in situ (DCIS) of the breast : psychological issues surrounding its detection, diagnosis and treatment." Thesis, University of Southampton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368057.

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45

Ohlsson, Sandra. "Evaluation and development of reagents and improved protocol for flow cytometry readout using in situ PLA." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-166431.

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The diagnosis of cancer today is obsolete, depending upon pattern recognition and non-quantifiable data. The time consuming diagnosis is often performed on biopsies, fixed using non standardised procedures, and leaves room for dubious results. The diagnosis is also invasive, exposing patients to risk of infections and discomfort due to the need of tissue samples. The knowledge about changes in protein expression levels related to cancer can instead be utilized to generate a new diagnostic tool. By adapting the in situ proximity ligation assay (in situ PLA) to cells in solution, it is possible

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46

Hirvonen, M. Karoliina. "Assay development for in situ detection of autophagy-related protein-protein interactions for characterization of colorectal cancer." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-254193.

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Every year, more than a million people are diagnosed with colorectal cancer (CRC) that develops in the large intestine. It is one of the most studied cancers in the world but still more knowledge about how this cancer develops and acts is needed in order to use more effective ways to treat CRC. Autophagy is a vital mechanism in cells that is also suggested to maintain cancer cell survival. In normal cells, it plays an important role by removing damaged cells and organelles as well as eliminating pathogens. Under metabolic stress this mechanism is induced to provide enough nutrients and energy

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47

Menzl, Ina, Lauren Lebeau, Ritu Pandey, et al. "Loss of primary cilia occurs early in breast cancer development." BioMed Central, 2014. http://hdl.handle.net/10150/610119.

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BACKGROUND:Primary cilia are microtubule-based organelles that protrude from the cell surface. Primary cilia play a critical role in development and disease through regulation of signaling pathways including the Hedgehog pathway. Recent mouse models have also linked ciliary dysfunction to cancer. However, little is known about the role of primary cilia in breast cancer development. Primary cilia expression was characterized in cancer cells as well as their surrounding stromal cells from 86 breast cancer patients by counting cilia and measuring cilia length. In addition, we examined cilia expre

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48

Svensson, Maria. "Assessing the ERG rearrangement for clinincal use in patients with prostrate cancer." Doctoral thesis, Örebro universitet, Institutionen för hälsovetenskap och medicin, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-28471.

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In Sweden, close to 10 000 men are annually diagnosed with prostate cancer (PCa) and approximately 2400 men die of their disease each year. Today there is no reliable marker that can separate patients who will have an aggressive type of disease that requires treatment, from patients who will have a more indolent clinical course and can be left untreated. This further leads to the current problem of over treatment of men with PCa. Hence, there is an urgent need for reliable prognostic markers that can be used at time of diagnosis. With the discovery of recurrent gene rearrangements in PCa, most

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49

MELLO, Gabriela Souto Vieira de. "Avaliação do glicocódigo presente no carcinoma ductal in situ de mama e sua relação na determinação do prognóstico e diagnóstico." UNIVERSIDADE FEDERAL DE PERNAMBUCO, 2014. https://repositorio.ufpe.br/handle/123456789/15217.

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Kardeby, Caroline. "The Concordance between Immunohistochemical Staining and Silver In Situ Hybridization for HER2 Status in Breast Cancer Tissue Samples." Thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-154951.

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The human epidermal growth factor receptor-2 (HER2) protein has been associated with breast cancer progression and the HER2 status can be used to determine the type of treatment for each breast cancer patient. The purpose of this study was to examine the HER2 protein and gene statuses in breast cancer tissue samples using two methods and analyze the concordance between them. Ten paraffin-embedded, formaldehyde-fixed breast cancer tissue samples from the Biobank at the Department of Pathology and Cytology at Sundsvall Hospital were analyzed in this study. All samples were from women born betwee

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