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Journal articles on the topic 'Vulvar cancer in situ'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

SPIRYDA, L. B., A. F. FULLER, and A. GOODMAN. "Aggressive locally recurrent vulvar cancer: review of cases presented to Massachusetts General Hospital 1990 to present." International Journal of Gynecologic Cancer 15, no. 5 (2005): 884–89. http://dx.doi.org/10.1136/ijgc-00009577-200509000-00027.

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Isolated recurrences of squamous cell vulvar carcinoma treated by surgical reexcision have excellent outcomes. There is a subset of these patients who develop multiple local recurrences that are difficult to manage and have a high risk of dying from their cancers. We reviewed women presenting with vulvar cancer (200 patients) to Massachusetts General Hospital from 1990 to present and identified 12 women with aggressive, locally recurrent squamous cell carcinomas of the vulva. The identified women all had successful primary radical vulvectomy and groin node dissections with negative surgical ma

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2

Dunaevskaya, V. "Characteristics of vaginal and vulvar microbiota in patients with vulvar precancerous lesions and vulvar squamous cell carcinoma." Journal of Education, Health and Sport 52 (January 31, 2024): 267–77. http://dx.doi.org/10.12775/jehs.2024.52.112.

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The aim of the study was to analyze the composition of the microbiota of the vagina and vulva in patients with precancerous lesions of the vulva in comparison with healthy controls and in women with vulvar cancer. Materials and methods. 286 women with vulvar lesions aged from 25 to 70 years and 60 gynecologically healthy women (30 under 50 years and 30 after 50 years) were included in the study. Patients with vulvar lesions were divided into 5 groups: 87 women with high-grade intraepithelial neoplasia of the vulva (VHSIL) dependent on the human papilloma virus (HPV) (Group 1 - G1), 154 women w

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3

Laukaitytė, Odeta, Gustė Brazytė, Tadas Latkauskas, and Saulius Paškauskas. "Concurrent Occurrence of Rectal Adenocarcinoma and Vulvar Keratinizing Squamous Cell Carcinoma: Case Report and Literature Review." Lietuvos chirurgija 24, no. 3 (2025): 212–20. https://doi.org/10.15388/lietchirur.2025.24(3).5.

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Introduction. Vulvar carcinoma is a rare malignancy, whereas rectal cancer is a more common oncological condition. However, the simultaneous occurrence of these two diseases is exceptionally rare. Case presentation. A 76-year-old woman presented with rectal bleeding and was previously diagnosed with keratinizing squamous cell carcinoma G1 of the vulva, unrelated to HPV. Imaging revealed tumor-like masses in the vulva and rectum, with pathological lymph nodes. Biopsy confirmed rectal adenocarcinoma in situ. She underwent obstructive rectal resection, colostomy formation, vulvar resection, and l

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Navarro Elias, Gallardo, Adriana Margarita Acosta Blanco, Mancera Steiner Carlos, and Francisco Garcia Rodriguez. "Squamous cell carcinoma in situ of the vulva." Hematology & Transfusion International Journal 11, no. 4 (2023): 119–21. http://dx.doi.org/10.15406/htij.2023.11.00318.

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Currently, squamous vulvar cancer is rare, which is why there is limited experience among health personnel in recognizing and managing this type of tumor location. The purpose of this case is to present the case of an 87-year-old woman with an ulcerative lesion on the vulva who underwent left vulvectomy with a report of squamous cell carcinoma in situ pathology, with favorable post-surgical evolution and without the need for adjuvant treatment when the inguinal lymph node was negative for metastasis.

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Secară, Diana, Daniela Meca, Sorin Vasilescu, et al. "Muscle-skeletal metastatic pattern in vulvar cancer." Romanian Journal of Orthopaedic Surgery and Traumatology 4, no. 2 (2021): 78–82. http://dx.doi.org/10.2478/rojost-2021-0014.

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Abstract Vulvar cancer is a rare malignancy of the genital tract, the fourth most common type in this category. The most common form of the clinical appearance is long-lasting pruritus, a lump or mass on the vulva. Despite its histological type, in most cases, invasive vulvar cancer metastasizes primarily through the lymphatic system. Bone metastases related to gynecological cancers are rare, often underdiagnosed, and have a very poor prognosis. The most common site of metastasis in vulvar cancer is the lung, which is affected in about 45%, followed closely by the liver and brain. Bone metasta

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Siegel, David A., Reda Wilson, Edward J. Wilkinson, et al. "Evaluation of the Vulvar Cancer Histology Code Reported by Central Cancer Registries: Importance in Epidemiology." Archives of Pathology & Laboratory Medicine 141, no. 1 (2016): 139–43. http://dx.doi.org/10.5858/arpa.2015-0422-oa.

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Context.—Knowing the subtype of vulvar cancer histology is important for estimating human papillomavirus–related cancer etiology. Surveillance of human papillomavirus–related vulvar cancers informs public health decisions related to vaccination against human papillomavirus. Objective.—To assess the accuracy of registry classifications of vulvar cancer and determine the histologic classification of cases reported as not otherwise specified. Design.—Pathology specimens were collected from Florida, Iowa, and Hawaii cancer registries. Registry diagnosis was compared with the pathology report from

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Gebauer, G., J. Schleibaum, S. Aulmann, P. Schirmacher, C. Sohn, and P. Sinn. "Low-level amplifications of the human telomerase gene (TERC) regularly is associated with vulvar intraepithelial neoplasia." Journal of Clinical Oncology 24, no. 18_suppl (2006): 20060. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.20060.

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20060 Background: Invasive squamous carcinomas of the vulva frequently harbor gains on the long arm of chromosome 3, including the human telomerase gene locus (TERC). Vulvar cancer develops from precursor lesions known as vulvar intraepithelial neoplasia (VIN) which frequently occur simultaneously in multiple locations and have a considerable risk or recurrence during follow-up. We investigated TERC gene copy number in a series of vulvar intraepithelial neoplasias to determine the risk of progression in these lesions. Methods: A total of 20 cases of high grade vulvar intraepithelial neoplasias

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8

Wu, Fiona, Uzma Andaleeb, and Ibrahim Ahmed. "Extramammary breast cancer of the vulva." BMJ Case Reports 17, no. 7 (2024): e259567. http://dx.doi.org/10.1136/bcr-2023-259567.

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A woman in her 70s was seen in the gynaecology outpatient clinic with a swelling on the right side of the vulva. Surgical excision of the lesion revealed unexpectedly an extensive ductal carcinoma in situ with a focus of a grade 2 invasive ductal carcinoma arising in extramammary breast tissue of the vulva. Postoperative staging studies showed normal breasts, with no evidence of disease elsewhere. The patient underwent a wider excision of the right vulva and sentinel node biopsy of the right inguinal region, which revealed no further disease. The patient is currently taking adjuvant hormonal t

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9

Swierczek, Sabina, Deep Pandya, Jean-Noel Billaud, et al. "Abstract 70: Metastatic versus primary: Genomic analysis suggests a metastatic origin for breast cancer previously diagnosed as metachronous vulvar ectopic breast cancer." Cancer Research 82, no. 12_Supplement (2022): 70. http://dx.doi.org/10.1158/1538-7445.am2022-70.

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Abstract Introduction: Accessory breast tissue is a rare finding in the general population with an incidence of 1-2%. Ectopic mammary tissue may occur anywhere along the milk line, from the axilla to the groin. Thus, breast cancer present in the vulva may arise as a primary breast adenocarcinoma or distant metastasis. Differentiating the two can be clinically challenging but is critically important as it impacts prognosis and treatment. Using genomic and bioinformatic approaches, we re-evaluated a previously histopathologically diagnosed rare case of metachronous vulvar ectopic breast cancer.

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10

Rosin, Jennifer, and Peter T. Silberstein. "Vulvar cancer: Presentation and treatment variation among races." Journal of Clinical Oncology 31, no. 15_suppl (2013): 5611. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.5611.

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5611 Background: Vulvar cancer is the fourth most common gynecologic malignancy. We analyzed variation among races in treatment, histology and stage at presentation using the National Cancer Database (NCDB). Methods: Between 2000 and 2010, 51,157 women from 1338 hospitals across the US were reported to the NCDB with vulvar cancer. Differences were assessed using Chi square analysis. Results: Caucasian patients with vulvar carcinoma in situ received no first course treatment significantly less than African American or Hispanic patients (3% vs 6% and 7%, p<0.05). No treatment for stage I and

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Dmitry, Tzerkovsky. "Photodynamic Therapy for Vulvar Carcinoma in situ (Case Report)." Journal of Cancer and Tumor International 5, no. 3 (2017): 1–5. https://doi.org/10.9734/JCTI/2017/33532.

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The article presents a clinical case of the successful application of photodynamic therapy with chlorine e6-based photosensitizer photolon in a patient with vulvar cancer in situ. The use of an exposure dose of light of 100 J/cm<sup>2</sup> made it possible to achieve complete clinical and morphological regression of the pathological focus, confirmed by control observations at 3 and 6 months.

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Bumanlag, Honeylyn C., and Jimmy A. Billod. "Vulvar Melanoma in the Elderly Treated with Surgery and Rradiotherapy: A Case Report." Asian Pacific Journal of Cancer Care 9, no. 3 (2024): 597–601. http://dx.doi.org/10.31557/apjcc.2024.9.3.597-601.

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Although rare, vulvar melanoma is the second most common histological type of vulvar cancer, representing around 10% of all malignant tumors involving the vulva presenting typically in post-menopausal women. The data on vulvar melanoma consists almost entirely of case studies and small retrospective series. A standardized approach to the diagnosis and management of vulvar melanoma is not available. In this paper, a case of vulvar melanoma in remission is described and a review of the current literature is presented. A 73-year-old, G5P5 (5-0-0-5), complained of a 3-year history of intense vagin

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Verschraegen, C. F., M. Benjapibal, W. Supakarapongkul, et al. "Vulvar melanoma at the M. D. Anderson Cancer Center: 25 years later." International Journal of Gynecologic Cancer 11, no. 5 (2001): 359–64. http://dx.doi.org/10.1136/ijgc-00009577-200109000-00004.

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The purpose of this study was to review the clinical course of patients diagnosed with vulvar melanoma. Charts of patients diagnosed between 1970 and 1997 were reviewed for demographics, lesion characteristics, disease duration and extent, and treatments. Actuarial survival curves were computed by the Kaplan Meier method and compared by Cox proportional hazards regressions. Fifty-one patients (median age 54) with vulvar melanoma presented with a vulvar mass (39%), pain (30%), bleeding (24%), and itching (20%). Anatomical distribution was mucosa of the vulva (65%), vulvar epidermal site (21%),

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Malik, Nasdaldy, M. Soemanadi, and Dewi Aisiyah Mukarramah. "Extensive Vulvectomy and Reconstructive Flaps for Advanced Vulvar Cancer in Young Woman: Case Reports." Indonesian Journal of Cancer 17, no. 4 (2023): 355. http://dx.doi.org/10.33371/ijoc.v17i4.1062.

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Introduction: : Vulvar cancer is a rare disease accounting for approximately 5% of female genital tract tumors worldwide. It is a squamous cell cancer that mostly affects older women over the age of 65. In the existing body of literature, no instances of vulvar cancer have been documented in the form of case reports. Therefore, this study aimed to report the challenges and outcomes of vulvectomy with reconstructive flap in vulvar cancer survivors in a 39-year-old woman. Case Presentation: A 39-year-old woman with a palpable lump around the vulva was present and being examined. The anatomic pat

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Lozar, Taja, Aysenur Keske, Racheal S. Dube Mandishora, et al. "Betapapillomaviruses in p16-Negative Vulvar Intraepithelial Lesions Associated with Squamous Cell Carcinoma." Viruses 15, no. 9 (2023): 1950. http://dx.doi.org/10.3390/v15091950.

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Approximately 40% of vulvar squamous cell carcinoma (vSCC) cases are etiologically associated with high-risk human papillomaviruses (HPVs) of the alpha genera (α-HPV) that cause other anogenital cancers; however, the etiology of α-HPV-negative vSCC is poorly understood. HPVs of the beta genera (β-HPV) are risk factors for cutaneous squamous cell carcinoma (cSCC) and may be related to carcinomas originating in other cutaneous sites such as the vulva. In this study, we investigate the presence of β-HPVs, with an emphasis on p16-negative squamous lesions adjacent to vSCC. We subjected 28 vulvar s

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Sturgeon, Susan R., Louise A. Brinton, Susan S. Devesa, and Robert J. Kurman. "In situ and invasive vulvar cancer incidence trends (1973 to 1987)." American Journal of Obstetrics and Gynecology 166, no. 5 (1992): 1482–85. http://dx.doi.org/10.1016/0002-9378(92)91623-i.

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17

Baumann, Klaus H., Olga Müller, Helke B. Naujok, Ellen Mann, Peter Barth, and Uwe Wagner. "Small-Area Analysis of Incidence and Localisation of Vulvar Cancer." Journal of Oncology 2010 (2010): 1–6. http://dx.doi.org/10.1155/2010/512032.

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Objective. Vulvar cancer is a rare disease mainly in older women. HPV and non-HPV induced vulvar cancer reflect two types of oncogenesis. Controversies exist on most recent developments in vulvar cancer incidence, patients, and disease characteristics. Changes in incidence, age of disease onset, and tumor site in women treated for primary vulvar cancer in a single German university hospital unit will be described.Methods. A retrospective analysis of patient records of women treated between 1994 and 2008 was performed. The fifteen-year-spanning period was divided into three five year-spanning c

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Barlow, Ellen L., Michael Jackson, and Neville F. Hacker. "The Prognostic Role of the Surgical Margins in Squamous Vulvar Cancer: A Retrospective Australian Study." Cancers 12, no. 11 (2020): 3375. http://dx.doi.org/10.3390/cancers12113375.

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For the last 30 years at the Royal Hospital for Women, unifocal vulvar squamous cancers have been treated by radical local excision, aiming to achieve a histopathological margin of ≥8 mm, equating to a surgical margin of 1 cm. The need for a margin of this width has recently been challenged. We aimed to determine the long-term outcome following this conservative approach, and the relationship between vulvar recurrences and surgical margins. Data were obtained retrospectively on 345 patients treated primarily with surgery for squamous vulvar cancer between 1987 and 2017. Median follow-up was 93

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Tataru, Ana-Liana, Gheorghe Furau, Jompan Afilon, et al. "The Situation of Cervical Cancers in the Context of Female Genital Cancer Clustering and Burden of Disease in Arad County, Romania." Journal of Clinical Medicine 8, no. 1 (2019): 96. http://dx.doi.org/10.3390/jcm8010096.

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Romania has the highest incidence of cervical cancer morbidity and mortality in Europe. This study identifies the major clusters for genital cancers, observes the features of genital and cervical cancer, and determines the extent to which cancer is a contributor to total Disability-Adjusted Life Year (DALY). Spatial analysis used Besag and Newell’s method for genital cancer distribution, prevalence considered Arad County patients records (2008–2017), and DALY was determined according to WHO methodology and GLOBOCAN 2013 data. Diagnosis was established by histopathological examination of diagno

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Andersen, B. L., J. Berek, H. Buchsbaum, et al. "Differential sexual outcomes following treatment of in situ vulvar cancer: A collaborative study." Gynecologic Oncology 32, no. 1 (1989): 131. http://dx.doi.org/10.1016/0090-8258(89)91019-6.

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Saraiya, Mona, Meg Watson, Xiaocheng Wu, et al. "Incidence of in situ and invasive vulvar cancer in the US, 1998-2003." Cancer 113, S10 (2008): 2865–72. http://dx.doi.org/10.1002/cncr.23759.

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22

Perrone, Anna Myriam, Martina Ferioli, Lisa Argnani, et al. "Quality of Life with Vulvar Carcinoma Treated with Palliative Electrochemotherapy: The ELECHTRA (ELEctroCHemoTherapy vulvaR cAncer) Study." Cancers 13, no. 7 (2021): 1622. http://dx.doi.org/10.3390/cancers13071622.

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The ELECHTRA (ELEctroChemoTherapy vulvaR cAncer) project was conceived to collect data on palliative electrochemotherapy (ECT) in vulvar cancer (VC) assessing patients’ outcomes (response and survival) and impact on quality of life (QoL). After reporting outcome data in 2019, here, we present the results on QoL. A multicenter prospective observational study was conducted on patients with VC refractory or not amenable to standard therapies undergoing palliative ECT as per clinical practice. The following questionnaires were administered before and after ECT (two and four months later, early and

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Shah, Princy, Kashyap Kela, and Upendra P. Hegde. "Gynecologic malignancies in women younger than 40 years of age: A SEER database review." Journal of Clinical Oncology 42, no. 16_suppl (2024): e17605-e17605. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e17605.

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e17605 Background: Gynecologic malignancies are one of the most common types of cancers in women, but their Epidemiology in young women is not widely known. Here we present the demographics and comparison between uterine, cervical, ovarian, vagina, and vulvar cancers in women under age 40 years based on the Surveillance, Epidemiology, and End Results (SEER) database analysis. Methods: Information was collected from the SEER database November 2022 with the data from years 2000-2020 containing 17 registries. Site recode ICD O-3/WHO 2008 Female Genital system was applied and Primary sites labeled

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Colaci, M., D. Giuggioli, G. Cassone, et al. "Gynaecological Screening for Cervical and Vulvar Malignancies in a Cohort of Systemic Sclerosis Patients: Our Experience and Review of the Literature." International Journal of Rheumatology 2015 (2015): 1–5. http://dx.doi.org/10.1155/2015/761867.

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Background. Increased incidence of cancer was frequently reported in scleroderma (SSc), but no association with gynaecological malignancies was described in literature.Objectives. To investigate gynaecological neoplasms in SSc patients.Methods. In this cross-sectional analysis, we evaluated 80 SSc patients, living in the same geographical area. We considered all patients undergoing gynaecological evaluation, including pap test as screening for cervical cancer, between January 2008 and December 2014.Results. 55 (68.7%) patients were negative and 20 (25%) presented inflammatory alterations, whil

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Vivod, Gregor, Masa Omerzel, Nina Kovacevic, et al. "Treatment of vulvar cancer recurrence with electrochemotherapy: a case-control study." Acta Oncologica 63 (May 21, 2024): 351–57. http://dx.doi.org/10.2340/1651-226x.2024.33241.

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Background: Electrochemotherapy (ECT) is a combined treatment method based on electroporation and simultaneous chemotherapy. In cases where radiotherapy has previously been used, surgery is often the only treatment option for vulvar cancer recurrence with potential resection of clitoris, vagina, urethra or anal sphincter. The unique advantage of ECT is its selectivity for cancer cells while sparing the surrounding healthy tissue. The aim of the study was to compare the ECT treatment of vulvar cancer recurrence for non-palliative purposes with surgical treatment. Materials and methods: Eleven p

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Advani, Pragati Gole, Christina R. Crabtree-Ide, Sarah Mullin, et al. "Risk patterns for second primary malignancies among human papillomavirus (HPV)–associated first primary cancer survivors in the United States." Journal of Clinical Oncology 43, no. 16_suppl (2025): 10516. https://doi.org/10.1200/jco.2025.43.16_suppl.10516.

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10516 Background: Previous studies have shown an increased risk of second primary malignancies (SPMs) among human papillomavirus (HPV)-associated first primary cancer (FPC) survivors; however, this has not been comprehensively examined by cancer site and patient’s sex. We utilized a large population-based database to examine disparities in SPM risk by site of HPV-associated first and second cancers. Methods: From 17 United States population-based Surveillance, Epidemiology and End Results (SEER) program cancer registry areas, we identified 124,802 ≥12-month survivors of HPV-associated invasive

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Sajo, Adekunle Emmanuel, Edwin Mnisi, Cathy Visser, Sheynaz Bassa, and Greta Dreyer. "Demographics, pathologic characteristics, and pattern of recurrence of vulvar cancer at an academic hospital in South Africa: A 10-year retrospective review." Journal of Clinical Oncology 42, no. 16_suppl (2024): e17602-e17602. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e17602.

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e17602 Background: Vulvar cancer although uncommon, accounts for about 5% of all gynecologic malignancies. Globally, it accounted for over 45 000 new cases and 17 000 deaths in the Globocan 2020 cancer estimates with an age-standardized rate (ASR) for incidence and mortality of 0.9 and 0.3 respectively. Vulvar cancer shares common risk factors with cervical cancer and over 90% of these are squamous cell carcinoma. In Africa, there is paucity of data on the true prevalence and recurrent rate of vulvar cancer albeit due to its rarity or poor record keeping. The current study aimed to describe th

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Osazuwa-Peters, Nosayaba, Matthew C. Simpson, Rebecca L. Rohde, Sai D. Challapalli, Sean T. Massa, and Eric Adjei Boakye. "Differences in Sociodemographic Correlates of Human Papillomavirus-Associated Cancer Survival in the United States." Cancer Control 28 (January 2021): 107327482110418. http://dx.doi.org/10.1177/10732748211041894.

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Objectives Human papillomavirus (HPV)-associated cancers account for about 9% of the cancer mortality burden in the United States; however, survival differs among sociodemographic factors. We determine sociodemographic and clinical variables associated with HPV-associated cancer survival. Methods Data derived from the Surveillance, Epidemiology, and End Results 18 cancer registry were analyzed for a cohort of adult patients diagnosed with a first primary HPV-associated cancer (anal, cervical, oropharyngeal, penile, vaginal, and vulvar cancers), between 2007 and 2015. Multivariable Fine and Gra

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Kojima, Naoki, Hiroshi Yoshida, Takashi Uehara, et al. "Primary Clear Cell Adenocarcinoma of the Vulva: A Case Study With Mutation Analysis and Literature Review." International Journal of Surgical Pathology 27, no. 7 (2019): 792–97. http://dx.doi.org/10.1177/1066896919848823.

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Primary vulvar clear cell carcinoma (CCC) is extremely rare. In this article, we report a primary vulvar CCC along with immunohistochemical and gene mutation analyses results and literature review to discuss the clinicopathological features and tumorigenesis of this rare tumor. A 70-year-old (gravida 2 para 2) Japanese woman complained of bleeding from a vulvar mass at a past episiotomy site. A 1.8 × 1.8 × 0.5 cm exophytic sessile mass was present on the vestibular area inside the left labium minora. Radical local excision of the tumor and resection of the inguinal lymph nodes on both sides we

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Cebolla-Verdugo, Marta, Victor Alfredo Cassini-Gómez de Cádiz, Juan Pablo Velasco-Amador, María Zulaika-Lloret, Francisco Manuel Almazán-Fernández, and Ricardo Ruiz-Villaverde. "Multidisciplinary Vulvar Cancer Management: The Dermatologist’s Perspective." Life 15, no. 1 (2024): 19. https://doi.org/10.3390/life15010019.

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Vulvar cancer, particularly squamous cell carcinoma (SCC) and melanoma, poses significant diagnostic and therapeutic challenges due to its complex presentation and high rates of postoperative complications. Effective management requires a multidisciplinary approach, integrating the expertise of gynecologic oncologists, dermatologists, plastic surgeons, and other specialists. This review highlights the dermatologist’s role in supporting early diagnosis, addressing predisposing conditions such as lichen sclerosus, and managing postoperative wound complications, including surgical site infections

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Papatheodorou, D. C., C. G. Liakou, K. Kalogerakos, Johannes Carl Athanasios Dimopoulos, and N. Kalinoglou. "Bilateral Breast Metastases from Vulvar Carcinoma: A Case Report and Literature Review." Case Reports in Obstetrics and Gynecology 2017 (2017): 1–3. http://dx.doi.org/10.1155/2017/1357203.

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Vulvar carcinoma is a rare disease that accounts for 3–5% of all gynecologic malignancies. Breast represents an unusual site of metastasis and only a few cases are reported. We describe the first case of bilateral metastatic breast carcinoma of vulvar origin, at an 80-year-old female patient. Six months after treatment of her primary disease, she presented with bilateral metastatic squamous cell breast carcinoma. Diagnosis was based on clinical, radiological, and histological facts. Breast although rare is another potential site of metastasis in vulvar cancer and thus mammary gland examination

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Paul, Diptajit, Abhishek Soni, Sumit S. Chatterjee, Abhirup Chanda, Vivek Kaushal, and Ashok Chauhan. "Ten Year Experience of Epidemiological Trends and Clinical Pattern of Vulvar Tumor." Asian Pacific Journal of Cancer Care 8, no. 3 (2023): 471–75. http://dx.doi.org/10.31557/apjcc.2023.8.3.471-475.

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Objectives: Vulvar tumor is a relatively uncommon female genito-urinary tumor, occurs mainly in post-menopausal females. Incidence and patterns of vulvar tumor differ from nation to nation, depending upon multiple factors. The aim of this study was to evaluate epidemiological patterns and clinical profile of vulvar tumor in our institution retrospectively. Methods: This is a retrospective study done in a regional cancer centre of India over10-years period. Data of all vulvar tumor patients, regarding demographic profile and tumor characteristics were collected from record section and reviewed.

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Windhofer, Christian, Christoph Papp, Alfons Staudach, and Wolfgang Michlits. "Local Fasciocutaneous Infragluteal (FCI) Flap for Vulvar and Vaginal Reconstruction: A New Technique in Cancer Surgery." International Journal of Gynecologic Cancer 22, no. 1 (2012): 132–38. http://dx.doi.org/10.1097/igc.0b013e318234fa0a.

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IntroductionSoft tissue reconstruction after vulvar, vaginal, or anal cancer resection poses a formidable task for reconstructive surgeons because of the functional, locational, and cosmetic importance of this region. Although numerous flaps have been designed for vulvar reconstruction, each has its disadvantages.MethodsThe authors introduce the local fasciocutaneous infragluteal (FCI) flap for vulvar and vaginal reconstruction after tumor resection, vaginal scar obliteration, and vulvar ulceration in 15 patients operated on between 1999 and 2007. The FCI flap is supplied by the cutaneous bran

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Fracchioli, S., M. Puopolo, I. A. Rigault De La Longrais, et al. "Primary “breast-like” cancer of the vulva: a case report and critical review of the literature." International Journal of Gynecologic Cancer 16, Suppl 1 (2006): 423–28. http://dx.doi.org/10.1136/ijgc-00009577-200602001-00079.

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Ectopic mammary gland tissue in the vulva is an uncommon clinical or pathologic finding. Such ectopic tissue can be the site of the same physiologic and pathologic processes found in the normal breast. However, the occurrence of adenocarcinoma is very rare, the first case being reported by Greene in 1935. We here report the 16th case of primary “breast-like” cancer arising in the vulva, together with a critical review of the literature, in order to highlight the dilemmas of a clinical approach to this neoplasm. Clear guidelines for diagnosis and therapy are still unavailable. The main diagnost

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Ong, Koh Jun, Marta Checchi, Lorna Burns, Charlotte Pavitt, Maarten J. Postma, and Mark Jit. "Systematic review and evidence synthesis of non-cervical human papillomavirus-related disease health system costs and quality of life estimates." Sexually Transmitted Infections 95, no. 1 (2018): 28–35. http://dx.doi.org/10.1136/sextrans-2018-053606.

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BackgroundMany economic evaluations of human papillomavirus vaccination should ideally consider multiple disease outcomes, including anogenital warts, respiratory papillomatosis and non-cervical cancers (eg, anal, oropharyngeal, penile, vulvar and vaginal cancers). However, published economic evaluations largely relied on estimates from single studies or informal rapid literature reviews.MethodsWe conducted a systematic review of articles up to June 2016 to identify costs and utility estimates admissible for an economic evaluation from a single-payer healthcare provider’s perspective. Meta-ana

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Simonsen, Ernst F. "Co2Laser Used for Cancer in Situ/Bowen's Disease (VIN) and Lichen Sclerosus in the Vulvar Region." Acta Obstetricia et Gynecologica Scandinavica 68, no. 6 (1989): 551–53. http://dx.doi.org/10.3109/00016348909015755.

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Zhou, Hongyu, Xuan Zou, Haoran Li, Lihua Chen, and Xi Cheng. "Construction and validation of a prognostic nomogram for primary vulvar melanoma: a SEER population-based study." Japanese Journal of Clinical Oncology 50, no. 12 (2020): 1386–94. http://dx.doi.org/10.1093/jjco/hyaa137.

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Abstract Background Primary vulvar melanoma was an aggressive and poorly understood gynecological tumor. Unlike cutaneous melanoma, the incidence of vulvar melanoma was low but the survival was poor. There were no standard staging system and no census on treatment strategies of vulvar melanoma. Therefore, we aimed to conduct and validate a comprehensive prognostic model for predicting overall survival of vulvar melanoma and provide guidance for clinical management. Methods Patients diagnosed with vulvar melanoma between year 2004 and 2015 from Surveillance, Epidemiology, and End Result (SEER)

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Martin, Alexandra L., J. Ryan Stewart, Harshitha Girithara-Gopalan, Jeremy T. Gaskins, Nicole J. McConnell, and Erin E. Medlin. "Trends and Complications of Vulvar Reconstruction After Vulvectomy: A Study of a Nationwide Cohort." International Journal of Gynecologic Cancer 28, no. 8 (2018): 1606–15. http://dx.doi.org/10.1097/igc.0000000000001332.

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ObjectivesThe objective of this study was to determine complications associated with primary closure compared with reconstruction after vulvar excision and predisposing factors to these complications.MethodsPatients undergoing vulvar excision with or without reconstruction from 2011 to 2015 were abstracted from the National Surgical Quality Improvement Program database. Common Procedural Terminology codes were used to characterize surgical procedures as vulvar excision alone or vulvar excision with reconstruction. Patient characteristics and 30-day outcomes were used to compare the 2 procedure

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Doll, Kemi Morenikeji, Ke Meng, Ethan M. Basch, Paola A. Gehrig, Wendy R. Brewster, and Anne-Marie Meyer. "Gynecologic cancer outcomes of Medicare's elderly poor: A population-based study of North Carolina." Journal of Clinical Oncology 32, no. 30_suppl (2014): 290. http://dx.doi.org/10.1200/jco.2014.32.30_suppl.290.

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290 Background: Women ≥ 65 years dually enrolled in Medicare and Medicaid (‘Duals’) represent an at-risk group in cancer care, yet their outcomes across the spectrum of gynecologic cancers have not been studied. Our goal was to compare the association of insurance type to stage at diagnosis and mortality of older women after a gynecologic cancer diagnosis. Methods: Population-based, retrospective cohort study of women ≥ 65 years, diagnosed with gynecologic cancers from 2003 – 2009 in North Carolina Central Cancer Registry files. Medicare, Medicaid, and claims from privately insured health plan

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Simonsen, Ernst F. "Co2 Laser Used For Cancer In Situ/Bowen'S Disease (Vin) And Lichen Sclerosus In The Vulvar Region." Acta Obstetricia et Gynecologica Scandinavica 68, no. 6 (1989): 551–53. http://dx.doi.org/10.1111/j.1600-0412.1989.tb07837.x.

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Gunia, Sven, Stefan Koch, and Matthias May. "Is CDX2 immunostaining useful for delineating anorectal from penile/vulvar squamous cancer in the setting of squamous cell carcinoma with clinically unknown primary site presenting with histologically confirmed inguinal lymph node metastasis?" Journal of Clinical Pathology 66, no. 2 (2012): 109–12. http://dx.doi.org/10.1136/jclinpath-2012-201138.

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AimsPenile, vulvar and anal squamous cell carcinomas (SCCs) share histomorphological overlap and are prone to lymphatic dissemination into inguinal nodes. Anal SCCs might derive from the anorectal zone (ARZ), anal transitional zone, squamous zone or from perianal skin. These anatomically distinct zones differ in terms of their embryological development. We sought to investigate the role of caudal-related homeobox 2 (CDX2), a homeobox gene implicated in the development and anterior/posterior pattern specification from duodenum to rectum including the ARZ, in terms of narrowing the possible site

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Lee, Kun, Jingyi Si, Ricai Han, et al. "A combined ultrastructural and gene molecular research for the relationship between human uterine cervical carcinoma and human papillomavirus." Proceedings, annual meeting, Electron Microscopy Society of America 48, no. 3 (1990): 204–5. http://dx.doi.org/10.1017/s042482010015856x.

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There are more supports for the view that human papillomavirus (HPV) infection might be an etiological factor in the development of cervical cancer when the association of persistent condylomata is considered. Biopsies from 318 cases with squamous cell carcinoma of uterine cervix, 48 with cervical and vulvar condylomata, 14 with cervical intraepithelial neoplasia (CIN), 34 with chronic cervicitis and 24 normal cervical epithelium were collected from 5 geographic regions of China with different cervical cancer mortalities. All specimens were prepared for Dot blot, Southern blot and in situ DNA-

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Ding, Wenpei, Yue Ma, Chao Ma, et al. "The lifetime cost estimation of human papillomavirus-related diseases in China: a modeling study." Journal of Translational Internal Medicine 9, no. 3 (2021): 200–211. http://dx.doi.org/10.2478/jtim-2021-0039.

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Abstract Objectives To estimate the lifetime treatment costs of patients with human papillomavirus (HPV) infection-related diseases in China and to provide cost estimates for the economic evaluation of HPV intervention strategies. Methods We extracted real-world hospital data from 2012 to 2019 and screened for subjects who met the criteria of clinical diagnosis of HPV-related diseases to obtain country-specific inputs into a Markov decision model. The model simulated lifetime treatment costs for HPV from the perspective of a national payer. A 5% discount rate was applied. Costs were converted

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Ishiguro, Akihiro, Nobuhiko Iwashita, Michihiro Abe, Akina Ogawa, Tomohiro Takeo, and Daisuke Watanabe. "Recurrence of Quadruple Extramammary Paget’s Disease after 12 Years: A Case Report and Literature Review." Case Reports in Dermatology 16, no. 1 (2024): 149–55. http://dx.doi.org/10.1159/000538675.

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Introduction: Extramammary Paget’s disease (EMPD) is a rare skin cancer that tends to be multicentric, with quadruple EMPD cases being scarcely reported. Case Presentation: We report the case of an 81-year-old man with heterochronous quadruple EMPD. Twelve years after total resection of vulvar EMPD, the patient developed erythematous lesions on the resection margin in the lower abdomen, umbilical region, and both axillae. Histological examination revealed that all lesions were in situ EMPD. Discussion: We reviewed six reported cases of quadruple EMPD with respect to race, sex, site, recurrence

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Franchi, Massimo, Stefano Uccella, Pier Carlo Zorzato, et al. "Vaginal flap for urethral neomeatus reconstruction after radical surgery for vulvar cancer: a retrospective cohort analysis." International Journal of Gynecologic Cancer 29, no. 7 (2019): 1098–104. http://dx.doi.org/10.1136/ijgc-2019-000420.

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IntroductionPartial urethrectomy during radical surgery for vulvar cancer may help avoid adjuvant radiotherapy in some patients. This study aimed to evaluate surgical, oncologic, and urinary outcomes of a new surgical technique based on vaginal flap to perform neomeatus reconstruction after distal urethral resection in radical surgery for vulvar cancer.MethodsRetrospective cohort study between January 2005 and December 2017. We recorded data on pre- and post-operative urinary symptoms, surgical procedures, complications, adjuvant therapy, and follow-up of all patients who underwent surgery for

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Kalpana, B., S. G. Balamurugan, and Soumya Ranjan Panda. "Vulval carcinoma at the site of recent Bartholin gland excision: a rare case report." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 5 (2020): 2148. http://dx.doi.org/10.18203/2320-1770.ijrcog20201821.

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Around 2-7% of all vulvar cancers are represented by primary carcinomas of Bartholin gland. Here we are presenting such a rare case of carcinoma of Bartholin gland. 45/F P2L2 presented in our OPD with non-healing lesion in vulva for 2 months. She had history of Bartholin’s cyst excision (elsewhere), 2 months back (the exact time since when she is having the non-healing lesion in vulva). Diagnostic biopsy revealed it to be vulval squamous cell carcinoma. She was given two cycles of Neo adjuvant chemotherapy (Inj. Paclitaxel and Carboplatin). In view of better response to the treatment patient w

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Rossato, Flaviana, Laura Teodoro Campos Faleiros, Luiza Teodoro Campos Faleiros, Luiz Felipe Nascimento de Oliveira, and Livia Ferreira Silva Verzola. "ANÁLISE MOLECULAR PARA PESQUISA DO PAPILOMAVÍRUS HUMANO (HPV) PELA REAÇÃO DE HIBRIDIZAÇÃO IN SITU." Revista ft 29, no. 141 (2024): 52–53. https://doi.org/10.69849/revistaft/fa10202412042352.

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Cervical cancer is a public health problem, as it has a high incidence of mortality in the country. In parallel, there is head and neck cancer, the sixth most common type. Although rare, vulvar cancer has a worldwide incidence of approximately 1.8/100,000 women. In addition to these, there is penile cancer which, although it is also a rare disease, has gradually increased in the country. Although all these cancers are very different and have their own particularities, they all have something in common, which is related to the risk factor for Human Papillomavirus (HPV) infection. HPV has a syst

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Hacker, Neville F., Ellen Barlow, Stephen Morrell, and Katrina Tang. "Medial Inguino-Femoral Lymphadenectomy for Vulvar Cancer: An Approach to Decrease Lymphedema without Compromising Survival." Cancers 13, no. 22 (2021): 5806. http://dx.doi.org/10.3390/cancers13225806.

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Background: Lower limb lymphedema is a long-term complication of inguino-femoral lymphadenectomy and is related to the number of lymph nodes removed. Our hypothesis was that lymph nodes lateral to the femoral artery could be left in situ if the medial nodes were negative, thereby decreasing this risk. Methods: We included patients with vulvar cancer of any histological type, even if the cancer extended medially to involve the urethra, anus, or vagina. We excluded patients whose tumor extended (i) laterally onto the thigh, (ii) posteriorly onto the buttocks, or (iii) anteriorly onto the mons pu

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DeKloe, Jefferson, Zachary David Urdang, Ubaldo E. Martinez Outschoorn, and Joseph M. Curry. "Effects of HPV vaccination on the development of HPV-related cancers: A retrospective analysis of a United States-based cohort." Journal of Clinical Oncology 42, no. 16_suppl (2024): 10507. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.10507.

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10507 Background: Several studies have shown the efficacy of the Human Papillomavirus (HPV) vaccine in reducing the risk of cervical cancer. Given the recent introduction of the HPV vaccine, there has been limited evidence linking vaccination to a decreased likelihood of developing other HPV-related cancers. Methods: A retrospective cohort study was conducted using a patient population selected from the TriNetX United States Collaborative Network. Patients 9-39 years old attending medical encounters where any vaccine was administered between 1/1/2010 and 12/31/2023 were divided into two cohort

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Perveen, Shakira, and Jai Mala. "Clinicopathological Pattern of Gynecological Malignancies at Tertiary Care Teaching Hospital." ANNALS OF ABBASI SHAHEED HOSPITAL AND KARACHI MEDICAL & DENTAL COLLEGE 27, no. 03 (2022): 80–86. http://dx.doi.org/10.58397/ashkmdc.v27i03.565.

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Objective: To view current clinicopathological pattern of gynecological malignancies at a tertiary care hospital in Karachi. Methods: This is a retrospective research performed in the department of obstetrics and gynecology unit 1 from January 2020 to December 2021. All cases of gynecological malignancies irrespective of age, race and cast were included for study. Around 164 cases with clinical or radiological diagnosis of malignancy were admitted for gynecological malignancy work up. Out of them 42 were confirmed on histopathology of biopsy or resected specimen. Patients with gestationa

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