Academic literature on the topic 'W.F. Norman Corporation'

In this paper we argue that the growing importance of the stock mark et i s one central element of t he s o called New Economy. W e analyse the economic and political reasons, the mechanisms and consequences of the increasing capital market orientation of enterprises. In the first section we want to show the fundamental difference between the maximisation of the stock price and of the profitability of the corporation. T he r easons o f the increasing c apital m ark et o rientation a re d ealt w ith in the second section. In the third section we are discussing the shareholder value concept. The institutional changes we can find in the German Corporate Governance system which are connected with the shareholder value debate are described in the fourth section. The last section sums up the consequences and the specific contradictions of the increasing capital market orientation like the contradiction between long-term and short-term maximisation of returns, the impending hollowing-out of firm competencies, and the proliferation of cash burning business models.

Background Myeloproliferative neoplasms (MPN) commonly result from mutations in genes encoding the kinase JAK2 or the multi-functional protein CALR. In preclinical studies, estrogen receptor alpha (ERα) modulation restores normal apoptosis in JAK2V617F hematopoietic progenitors (HSPCs). Use of selective ER modulators (SERM) such as tamoxifen may permit the molecular reduction of MPNs. Methods TAMARIN is a Trials Acceleration Programme, Phase II, multicentre, single arm A'herns design clinical trial assessing tamoxifen's safety and activity in reducing molecular markers of disease burden in MPN male patients aged ≥60 years and post-menopausal female patients with stable blood counts, no history of thrombosis and ≥20% mutated JAK2V617F, CALR 5bp insertion or CALR 52bp deletion. Based on tamoxifen's safety profile in ER+ breast cancer, an oral dose of 20 mg once daily was initially given and progressively escalated to 40 mg, in addition to standard cytoreductive therapy (excluding treatments known to lower allele burden eg interferon). Mutant allele burden was measured after 12 and 24 weeks (w) of treatment. The A'herns success criteria required the primary outcome (>50% reduction in allele burden at 24w) be observed in ≥3 patients (Barosi Leuk. 2015). Patient blood (baseline, 12 and 24w) samples were collected and CD34+ HSPCs were isolated in a subset for RNA-Seq, which was also performed on HEL and UKE-1 JAK2V617F-mutated human cell lines treated with tamoxifen/vehicle. Apoptosis and oxidative phosphorylation (OXPHOS) were measured in SERM-treated cell lines for confirmation. Results and Discussion 38 patients (37% essential thrombocythaemia (ET), 29% polycythaemia vera (PV), 16% primary myelofibrosis (PMF), 13% post-PV MF and 5% post-ET MF) were recruited over 112w. 33 patients completed ≥24w of tamoxifen treatment, 1 was untreated, 1 discontinued following an unprovoked thrombotic event and 3 discontinued due to toxicity. 4 patients achieved the primary outcome and 6 additional patients met the secondary outcome (≥25% reduction)(A-B). Responders included 4 JAK2V617F PV males, a JAK2V617F PMF female and ET patients of both genders carrying JAK2V617F, CALRdel52 or CALRins5 mutations. 4 patients remain on trial treatment beyond 48w as they are considered to be deriving clinical benefit. Two grade 3 adverse events unrelated to tamoxifen, as well as 1 superficial thrombophlebitis and 1 deep vein thrombosis (grade 2) occurred on study. HSPC transcriptome seggregates responders and non-responders perfectly at baseline (C), suggesting a potential predictive signature of response. Pathway analysis of differentially-expressed genes shows enrichment of myeloid differentiation and hormone-dependent transcriptional complex assembly in responders at baseline. In contrast, chromosome segregation, DNA replication, and chromosome condensation pathways are enriched in non-responders. Gene-set enrichment analysis (GSEA) reveals increased apoptosis and oxidative phosphorylation (OXPHOS) signatures in responders at baseline (D). Upregulated genes in responders are associated with H3K4me1 modification whilst genes upregulated in non-responders are associated with H3K9me3, suggesting the possibility that chromatin modifications account for tamoxifen sensitivity. 24w after treatment, OXPHOS and ROS pathways are downregulated in responder HSPCs (E) but upregulated in non-responders (F), suggesting striking differences in the metabolism of HSPCs in both groups and/or the eradication of sensitive HSPCs in responders. Reduced OXPHOS pathways and deregulated expression of unfolded protein response (UPR) genes were confirmed in HEL and UKE-1 cells. In fact, tamoxifen induces dose-dependent apoptosis in HEL and UKE-1 cells, where serum deprivation or UPR inducers sensitize resistant cells to tamoxifen-induced apoptosis, which is associated with decreased OXPHOS and energy (ATP) production. Conclusions These results demonstrate the safety and activity of tamoxifen in reducing mutant allele burden in a subset of MPN patients who could be prospectively identified based on their transcriptomic signature at baseline. Tamoxifen can induce apoptosis of human JAK2V617F or CALR mutated HSPCs through metabolic and transcriptional effects. These results advocate for future studies to test the effects of SERMs in MPN with careful consideration of thrombotic risk. Disclosures Harrison: Roche: Honoraria; Novartis: Honoraria, Research Funding, Speakers Bureau; Janssen: Speakers Bureau; AOP Orphan Pharmaceuticals: Honoraria; Promedior: Honoraria; Shire: Honoraria, Speakers Bureau; CTI Biopharma Corp: Honoraria, Speakers Bureau; Celgene: Honoraria, Research Funding, Speakers Bureau; Sierra Oncology: Honoraria; Gilead Sciences: Honoraria, Speakers Bureau; Incyte Corporation: Speakers Bureau. Mead:CTI: Consultancy; Gilead: Consultancy; Celgene/BMS: Consultancy, Honoraria, Other: travel, accommodations, expenses, Research Funding; Novartis: Consultancy, Honoraria, Other: travel, accommodations, expenses, Research Funding, Speakers Bureau; Abbvie: Consultancy. Knapper:Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding. Ewing:Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Incyte: Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Celgene/BMS: Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau. McMullin:Jazz Pharmaceuticals: Membership on an entity's Board of Directors or advisory committees; Novartis: Membership on an entity's Board of Directors or advisory committees; BMS: Consultancy; Celgene: Consultancy; Abbvie: Membership on an entity's Board of Directors or advisory committees. Narayanan:Novartis: Other: Educational support to attend conferences; MSD: Speakers Bureau; Celgene: Other: Educational support to attend conferences; Alexion: Speakers Bureau; Takeda: Other: Educational support to attend conferences. Milojkovic:Incyte: Consultancy, Honoraria; Pfizer: Consultancy, Honoraria; Novartis: Consultancy, Honoraria; Bristol-Myers Squibb: Consultancy, Honoraria. Drummond:Jazz: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Pfizer: Consultancy, Membership on an entity's Board of Directors or advisory committees; Novartis: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Gilead: Membership on an entity's Board of Directors or advisory committees; Takeda: Membership on an entity's Board of Directors or advisory committees; Blueprint Medicine Corporation: Research Funding; Astellas: Membership on an entity's Board of Directors or advisory committees; Bristol Myers Squibb: Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau. OffLabel Disclosure: Tamoxifen is a selective estrogen receptor modulator frequently used in estrogen receptor-positive breast cancer.

The article investigates the necessity and organization of continuous training of personnel in corporate systems. The methods of solving the problem of selection, training and adaptation of personnel, taking into account the peculiarities of socio-economic systems of production enterprises-branches of transnational companies. The analysis of the model of training of personnel of the enterprises of the automotive cluster is carried out. For the solution of control problems in organizational systems of multinational companies Model Shlyonsky, F. O. and B. W. Bode, the author adapted to the peculiarities of these companies. The features of the automotive cluster of Kaluga region are described. The substantiation of not required re-training of employees in corporate standards is given. when switching to work from one of the cluster enterprises to another. It is concluded that the competition within the cluster between enterprises, with this approach, contributes to the success of each enterprise included in it and the development of the cluster as a whole.

During 1991 large-scale excavations at Sagalassos continued for their second season from 13 July until 5 September. The work was directed by Professor Marc Waelkens (Dept. of Archaeology, Catholic University of Leuven). A total of 42 scientists from various countries (Belgium, Turkey, Great Britain, Germany and Portugal) as well as 25 local workmen (supervised by Mr. Ali Toprak) carried out the work. The team included 20 archaeologists, 4 illustrators (supervised by G. Evsever and R. Kotsch), 4 architect-restorers (directed by Prof. R. Lemaire and Dr. K. Van Balen), 3 cartographers (directed by Prof. F Depuydt), 2 geologists (directed by Prof. W. Viaene), 2 geomorphologists (Prof. J. De Ploey and Prof. E. Paulissen), 1 archaeozoologist (Dr. W. Van Neer), 1 anthropologist (Dr. Chr. Charlier), 2 restorers for the small finds (directed by Miss K. Norman) and 1 photographer (P. Stuyven). The Turkish Antiquities Department was represented by Muhammet Alkan from the Sivas Museum, whom we thank for his help. Financial support came from the Research Council of the Catholic University of Leuven, the Belgian Fund for Collective Fundamental Research (F.K.F.O.), the Belgian Programme on Interuniversity Poles of Attraction (I.U.A.P. no 28), the National Bank of Belgium, the ASLK/CGER Bank, the tour operator ORION, the car rental company Interleasing, the restoration company E. G. Verstraete & Vanhecke N. V., Agfa-Gevaert films and the association “Friends of Sagalassos”.

Legends of Artificial Lift This year, the SPE Artificial Lift Conference and Exhibition–Americas will be held 23–25 August in Galveston, Texas, with the theme “Modern Artificial Lift–Adapting to a Changing Industry.” The event provides opportunities for technical professionals to gain insights into current trends and field experiences and explore innovative solutions. A special Legends of Artificial Lift Luncheon on 23 August will celebrate three individuals for their outstanding contributions to the technical knowledge in this field: Norman Hein Jr., Ken Nolen, and Gabor Takacs. Norman W. Hein Jr. Norman W. Hein Jr. has worked for 45 years in upstream production, his distinguished career spanning from research, development, and testing to ventures in production engineering, manufacturing, onshore and offshore project management, industry standardization, and the principles of artificial lift. Hein joined the industry in 1977 as a research scientist with Continental Oil Company, where he learned about oil and gas production materials, failures, fatigue, and offshore construction. He then worked for Conoco and later ConocoPhillips in various engineering positions. In 2010, he joined the sucker-rod division of Norris Production Solutions as director of research, development, engineering, and quality; later at CONSOL Energy he was promoted to chief technology professional and senior advisor. Currently, Hein is president and managing director of Oil and Gas Optimization Specialists Ltd., which he established in 2003. Kenneth B. (Ken) Nolen Kenneth B. (Ken) Nolen for 62 years has been a key contributor to what he calls “the art and science of artificial lift.” “My college degree in mechanical engineering was largely devoted to science,” he explains, “and that’s a branch of knowledge dealing with the physical world of facts and principles. Art, on the other hand, uses science to create new technology and products—in my field, that is to enhance artificial lift.” His career in optimizing this art and science began after graduating from Texas A&M and serving his country in the US Air Force for a 3-year tour. Nolen joined Shell Oil Company as a production engineer before teaming up with Dr. Sam G. Gibbs to become co-founderand vice president of Nabla Corporation in Midland, Texas—a technical service company that specialized in artificial-lift diagnosis, optimization, design, training on pumping wells, and manufacturing pumpoff controllers and fluid-level sounders. “It was at Nabla that I pursued my long-held passion for optimizing production from artificially lifted wells.” Gabor Takacs Gabor Takacs joins the Legends of Artificial Lift as an internationally recognized consultant with more than 35 years of consulting and teaching experience in the fields of production engineering, with a concentration in artificial lift. “The great honor of being nominated is an absolutely thrilling sensation for me,” he said. “It gives me a special satisfaction to be the first foreigner to join those wonderful people whom I have been privileged to meet and cooperate with during my career.” Takacs is a professor emeritus at the University of Miskolc, Hungary, where he led the petroleum engineering department from 1995 to 2012.

DAS WERDEN DER AGRARLANDSCHAFT IN DER GRAFSCHAFT TIPPERARY (IRLAND). Ingeborg Leister. Marburger Geographische Schriften, Heft 18, 1963. 434 pp. 21 DM.LAND USE IN NORTHERN IRELAND. General Report of the Land Utilisation Survey of Northern Ireland. Editor, Leslie Symons. University of London Press Ltd. 1963. pp. 288. £2–2‐0.WEST CORK RESOURCE SURVEY. Prepared and published by an Foras Talúntais (Agricultural Institute). Dublin 1963. £1.GEOLOGY AND IRELAND. W. E. Nevill. Dublin: Figgis, 1963. 8#fr1/2> × 5#fr1/2> in., xv + 263 pp., 65 text figures. 25s.RECENT RESEARCH ON IRISH RURAL SETTLEMENT. The report of a symposium held at Belfast, January 1963. By Ronald H. Buchanan. Belfast: Geography Department, The Queen's University. 1/‐.COUNTY LONDONDERRY HANDBOOK. Belfast: Nicholson & Bass. (no date) 2s. 6d.L'EUROPE DU NORD ET DU NORD‐OUEST. Tome III. LES ILES BRITANNIQUES. J. Beaujeu‐Garnier and A. Guilcher. ‘Orbis’ Introduction aux Etudes de Geographie. Paris: Presses Universitaires de France, 1963. 560pp. F.32.THE ECONOMIC PATTERN OF MODERN GERMANY, by Norman G. Pounds. London: John Murray, 1963. Pp. 133. 80#fr1/2> × 5#fr1/4> in. 18s.NORTH AMERICA. N. J. G. Pounds. London: John Murray, 2nd. ed., 1964. 238 pp. 18s. 6d.THE EARTH AND YOU. Norman J. G. Pounds. London: John Murry, 1963. 591 pp. 60s.INDUSTRIALISATION AND UNDER‐DEVELOPED COUNTRIES, by Alan B. Mountjoy. London: Hutchinson University Library, 1963. 223 pp. 15s.ATLAS OF CENTRAL EUROPE. London: J. Murray, 1963. 13 ins. × 9#fr1/2> ins. 42s.STATISTICAL MAPPING AND THE PRESENTATION OF STATISTICS. G C. Dickenson. London: Edward Arnold Ltd., 1963. 160pp. 21s.INTERNATIONAL YEARBOOK OF CARTOGRAPHY, III, 1963. Edited by Eduard Imhof. London: George Philip and Son Ltd., 1963. Pp. 232. 9#fr1/2> × 6#fr1/2> in. 40s.

Abstract Cement is a hazardous and expensive material that is used in the production of concrete, where the cost of the concrete is minimized by replacing the cement with similar cementitious materials. According to the report of the national thermal power corporation, the production of fly ash is rising each year as a result of increasing demand for electricity. In this research paper, an attempt has been done by replacing cement with fly ash as an alternative material. The concrete samples are prepared with different compositions by using different percentages (0%, 10%, 20%, 30%, 40%, 50%, and 60%) of fly ash. In this research, the behaviour of the fly ash concrete is investigated by different strength-related properties; compressive strength, splitting tensile strength, and flexural strength at various curing time periods of 7, 28, 56, 90, and 180 days. In the experimental section, the developed fly ash concrete obtained maximum compressive strength of 83.50N / mm 2, a flexural strength of 6.60N / mm 2 and a splitting tensile strength of 4.90N / mm 2 on the 180th day in the composition of 450kg/m 3 and 0.4W/B ratio. Percentage gain of compressive, split tensile and flexural tests for 450 kg/m3 at 0.4 W/B ratio at 180 days curing is 13%, 9% and 13% with 30% fly ash replacement when compared to 350 kg/m3 binder content. Proportional increase of cement content also leads to increase fly ash content in concrete. Fly ash has potential of filling pores because of having finer particles and performs pozzolanic action which resulted in attaining high strength even after optimum replacement when compared to conventional concrete.

Includes the following reviews: pp. 76-77. Elisabeth Ahlsén. Magnusson, E. & Nauclér, K. (eds.), Reading and Spelling Disabilities: Linguistic Etiology. pp. 77-80. Mats Mobärg. Lewin, E. & Lewin, A.E., The Thesaurus of Slang. pp. 81-82. Norman Vance. Bryans, R., Ulster: A Journey through the Six Counties. + McKittrick, D., Despatches from Belfast. pp. 82-83. Stephen Medcalf. Wetherbee, W., Geoffrey Chaucer, The Cantebury Tales. pp. 83-84. Jeremy Lane. Taylor, D.J., A Vain Conceit: British Fiction in the 1980s. pp. 84-86. Britt-Marie Kylander. Wahlman, B. (projektledare) m.fl., Franska ordboken. p. 87. Olof Eriksson. Livres nouveaux. pp. 87-88. Marie-Rose Blomgren. Merle, P., Dictionnaire du Français branché suivi du Guide du français tic et toc. pp. 89-91. Gunnar Magnusson. Krumm, H.-J. (Hrsg.), Handbuch Fremdsprachenunterricht. pp. 92-93. Gustav Korlén. Duden, Deutsches Universalwörterbuch. 2 Aufl. pp. 93-94. Evald Johansson. Freund, F. & Sunqvist, B., Tysk grammatik, övningsbok och Tysk grammatik, övningsbok, facit. pp. 95-97. Birgit Stolt. Graf von Krockow, C., Die Stunde der Frauen. Bericht aus Pommern 1944-47. + Gräfin von Maltzan, M., Schlage die Trommel und fürchte dich nicht. pp. 97-99. Michael Opitz. Janka, W., Schwierigkeiten mit der Wahrheit. pp. 99-101. Annelise Stawström. Köningsdorf, H., Lichtverhältnisse. pp. 101-103. Christiane Baumann. Bleisch, N., Kontrollverlust. p. 104. Helmut Müssener. Internat. Deutschlehrerverg (Hrsg.), Dem Frieden entgegen. Ein Lesebuch mit 100 Texten aus fünf Jahrhunderten. p. 104. Helmut Müssener. Peters, J. (Hrsg.), Zweimal Stockholm-Berlin 1946. Briefe nach der Rückkehr: Jürgen Peters und Wolfgang Steinitz. Mit Nachfragen an Robert Rompe und Jürgen Kuszynski.

Das Jahrbuch „Extremismus & Demokratie“ fördert die wissenschaftliche Beschäftigung mit dem Problemkreis des politischen Extremismus in seinen verschiedenen Ausprägungen. Es versteht sich als Diskussionsforum, Nachschlagewerk und Orientierungshilfe zugleich. Der 32. Band dokumentiert, kommentiert und analysiert umfassend die Entwicklung im Berichtsjahr 2019. Aktuelle Schwerpunkte bilden u. a. die Auseinandersetzung mit dem Hufeisenmodell und dem Gebot der Äquidistanz, die linkspopulistische Bewegung #aufstehen, die Autonomiebestrebungen in Schottland, der Islamische Staat, die linksextremistische Interventionistische Linke, eine aktuelle Untersuchung der rechtsextremistischen und rechtsterroristischen Akteure in Deutschland sowie eine Ursachsenanalyse der Radikalisierung von Islamisten. Neben Analysen, Daten und Dokumenten findet sich ein umfassender Literaturteil mit Rezensionen der wichtigsten Publikationen zu Fragen von Extremismus und Demokratie in Geschichte und Gegenwart. Mit Beiträgen von Alexander Akel, Uwe Backes, Dirk Baehr, Manuel Becker, Harald Bergsdorf , Klaus von Beyme, Evelyn Bokler-Völkel, Marcel Boldorf, Wilfried von Bredow, Stefan Breuer, Hubertus Buchstein, Juliane Clegg, Philipp Currle, Frank Decker, Norman Domeier, Jost Dülffer, Kristin Eichhorn, Alexander Gallus, Phillipp Gassert, Michael Gehler, Birgit Glorius, Stefan Goertz, Sebastian Gräfe, Bernd Greiner, Katrin Groh, Florian Grotz, Thomas Grumke, Anna-Maria Haase, Jens Hacke, Stephan Hilsberg, Kai Hirschmann, Lukas Hämisch, Thomas Jäger, Helge F. Jani, Hans-Gerd Jaschke, Eckhard Jesse, Ralph Jessen, Thomas Kern, Ilko-Sascha Kowalczuk, Wolfgang Kraushaar, Jakob Kullik, Jürgen P. Lang, Oliver W. Lembcke, Sebastian Liebold, Josefa Loebell, Tom Mannewitz, Miroslav Mareš, Julian Meinelt, Tilman Mayer, Reinhard Mehring, Lazaros Miliopoulos, Werner Müller, Helmut Müller-Enbergs, Herfried Münkler, Beate Neuss, Paul Nolte, Robert Chr. van Ooyen, Torsten Oppelland, Isabelle-Christine Panreck, Anton Pelinka, Armin Pfahl-Traughber, Gert Pickel, Jürgen Plöhn, Kim C. Priemel, Robert Radu, Claudia Ritzi, Gabriel Rolfes, Philp Rosin, Martin Sabrow, Kurt Schilde, Christine Schirrmacher, Mike Schmeitzner, Brigitte Seebacher, Daniel Siemens, Grit Straßenberger, Martina Steber, Roland Sturm, Tom Thieme, Hendrik Thoß, Margarete Tiessen, Heike Tuchscheerer, Daniela Weber, Manès Weisskircher, Bernd Jürgen Wendt, Nikolaus Werz, Gerhard Wettig, Benedikt Wintgens, Sandra Wirth und Samuel Zeitlin.

Investigators at Triangle Research and Development Corporation (TRDC) have developed materials and applications for enhanced thermal management using both micro-and macro-encapsulated phase change materials (PCMs) since 1983; including: microPCM coolants, coatings, composites, fibers and PCM apparel. The PECS™ (Personal Environmental Control System) was developed for microclimate body cooling beneath NBC (Nuclear-Biological-Chemical) protective clothing for the US NAVY and USMC (Colvin, 1997 and 2000). Similar cooling apparel using 3–4mm macroPCM COOLBEADS™ were developed for costumed characters at two theme parks as well as potential use by firemen (Colvin, 1998). The results for these programs were reported at the 2000 and 2002 ASME ICEME (Colvin, 2000 and 2002). Civilian apparel has included 3.5 lb and 5 lb vests, a 1.5 lb cowl as well as a 1-lb collar, which suggested the potential for the microclimate cooling of athletes. Extreme heat during outdoor sporting events can be a major problem for athletes. Competitive runners, who often generate 700–900 W/m2, commonly deal with temperatures above 32.2°C (90°F) and a relative humidity greater than 80%. Natural cooling by evaporation and convection are often inadequate for a vigorously exercising athlete. Many athletes fatigue, drop out or have to wrap their chest and shoulders with ices and towels in order to finish the races. Ice and frozen gels, however, are uncomfortable, heavy, and can cause the blood vessels to constrict, thus restricting good blood circulation. Encapsulated PCMs can store 60 J/kg and the air spaces between the particles permit evaporation and convection as well as rapid thermal recharging. Development of an effective cooling collar could potentially permit competitive athletes to combat heat exhaustion and increase the body’s ability to dissipate heat.