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Journal articles on the topic 'W. Somnifera'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Adhikari, Lokesh, Rupali Kotiyal, Mukesh Pandey, Meenakshi Bharkatiya, Ajay Sematy, and Mona Semalty. "Effect of Geographical Location and Type of Extract on Total Phenol/Flavon Contents and Antioxidant Activity of Different Fruits Extracts of Withania somnifera." Current Drug Discovery Technologies 17, no. 1 (2020): 92–99. http://dx.doi.org/10.2174/1570163815666180807100456.

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Background:Withania somnifera (family solanaceae) is a well-investigated medicinal plant which is also called Indian ginseng due to its wide spectrum of medicinal properties. The contents and activity of the plant may vary depending on the habitat and part of the plant and the solvent used for extraction. The present study deals with the comparative chemical analysis and in vitro antioxidant activity of methanolic fruits extracts and its subfractions (in ethyl acetate, butanol and water) of W. somnifera collected from two different geographical locations.Methods:In the present study, Withania

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Lerose, Valentina, Maria Ponticelli, Nadia Benedetto, et al. "Withania somnifera (L.) Dunal, a Potential Source of Phytochemicals for Treating Neurodegenerative Diseases: A Systematic Review." Plants 13, no. 6 (2024): 771. http://dx.doi.org/10.3390/plants13060771.

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Withania somnifera (L.) Dunal is a medicinal plant belonging to the traditional Indian medical system, showing various therapeutic effects such as anti-cancer, anti-inflammatory, anti-microbial, anti-diabetic, and hepatoprotective activity. Of great interest is W. somnifera’s potential beneficial effect against neurodegenerative diseases, since the authorized medicinal treatments can only delay disease progression and provide symptomatic relief and are not without side effects. A systematic search of PubMed and Scopus databases was performed to identify preclinical and clinical studies focusin

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Jamalludin, Nurul Bariah, and Nurhuda Manshoor. "Ethnobotanical importance, phytochemical constituents, and pharmacological properties of Withania somnifera." Journal of Herbmed Pharmacology 11, no. 3 (2022): 320–29. http://dx.doi.org/10.34172/jhp.2022.37.

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Withania somnifera belongs to the family of Solanaceae. It is widely used by the locals, especially in India, as a medicinal plant. W. somnifera is rich in alkaloid and steroidal lactone that account for various pharmacological activities. The present study aimed to review all the evidence on the ethnobotanical perspective of W. somnifera in some countries. This review also analyses the bioactive compounds that account for the pharmacological activities. The online medical literature databases such as ScienceDirect, PubMed, and Google Scholar were used to search articles up to March 2022. W. s

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Tehri, Kanika, and Rachna Gulati. "Field efficacy of some biorationals against the two spotted spider mite Tetranychus urticae Koch (Acari: Tetranychidae)." Journal of Applied and Natural Science 6, no. 1 (2014): 62–67. http://dx.doi.org/10.31018/jans.v6i1.376.

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Field trials were conducted to evaluate the acaricidal potential of entomopathogenic fungus, Beauveria bassiana and aqueous extracts of Withania somnifera and Glyccirrhyza glabra against the mobile stages of Tetranychus urticae Koch on cucumber. The treatments responded in a concentration dependent manner. Highest reduction in T. urticae population was achieved with Omite (0.05%) followed by Nimbecidine (5ml/l), B. bassiana (1010 spores ml-1), W. somnifera (7.5%), B. bassiana (108 spores ml-1), G. Glabra (7.5%), G. Glabra (5%), G. Glabra (2.5%), W. somnifera (5%) and W. somnifera (2.5%). Highe

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Jassal, Prabhjot Singh, and Gagandeep Kaur. "COMPARATIVE ANALYSIS OF ANTIOXIDANT ACTIVITY AND PHYTOCHEMICAL CONTENTS IN ETHANOLIC LEAF EXTRACTS OF IN VITRO AND FIELD GROWN WITHANIA SOMNIFERA." Asian Journal of Pharmaceutical and Clinical Research 9, no. 5 (2016): 239. http://dx.doi.org/10.22159/ajpcr.2016.v9i5.13370.

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ABSTRACTObjective: The present study was planned to compare antioxidant activity in vitro and field grown Withania somnifera was assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and nitric oxide (NO) assays. Medicinal plants are a major source of phytochemicals used for the treatments ofhuman diseases. W. somnifera has anti-inflammatory, antioxidant, and antimicrobial properties.Methods: Antioxidant activity and phytochemical contents in W. somnifera were determined spectrophotometrically.Results: The results of antioxidant activity of field grown ethanolic leaf extract of W. somnifera show

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Hammood, Mahmood Neamah, Liqaa Hasson Saqban, and Nazar Jebar Metib. "Protective Role of Withania somnifera Against the Adverse Effects of Levofloxacin on Testes Tissue of Rats In Vivo." Medical Journal of Babylon 22, no. 1 (2025): 41–49. https://doi.org/10.4103/mjbl.mjbl_174_23.

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Abstract Background: Medicinal plants have many uses in traditional medicine in all cultures due to their unique therapeutic properties. Withania somnifera is considered an agent to improve sexual health, an antioxidant, anti-aging, and anti-inflammatory. Objective: This study aimed to determine the therapeutic effect of W. somnifera on the potential Levofloxacin-induced testicular injury in rats. Materials and Methods: Thirty adult male Wistar rats were randomly divided into five groups: control group (C), saline-treated for 60 days. Group (W) W. somnifera root extract was orally treated for

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Pandey, Umesh Chandra, Karunakar Shukla, and Rakesh Kumar Jatav. "Pharmacognostical, Phytochemical Screening and Evaluation of Anxiolytic activity of Alcoholic Extract of Withania somnifera (L) Dunal Roots." Journal of Drug Delivery and Therapeutics 13, no. 5 (2023): 29–34. http://dx.doi.org/10.22270/jddt.v13i5.5806.

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The roots of Withania somnifera (L) Dunal (W. somnifera) are used extensively in Ayurveda, the classical Indian system of medicine, and W. somnifera is categorized as a rasayana, which are used to promote physical and mental health, to provide defense against disease and adverse environmental factors and to arrest the aging process. W. somnifera has been used to stabilize mood in patients with behavioural disturbances. The objective of this study was to investigate pharmacognostical, phytochemical features and anxiolytic activity of alcoholic extracts of W. somnifera roots. The various pharmac

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Gaurav, Harshita, Divyanshu Yadav, Ankita Maurya, et al. "Biodiversity, Biochemical Profiling, and Pharmaco-Commercial Applications of Withania somnifera: A Review." Molecules 28, no. 3 (2023): 1208. http://dx.doi.org/10.3390/molecules28031208.

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Withania somnifera L. Dunal (Ashwagandha), a key medicinal plant native to India, is used globally to manage various ailments. This review focuses on the traditional uses, botany, phytochemistry, and pharmacological advances of its plant-derived constituents. It has been reported that at least 62 crucial and 48 inferior primary and secondary metabolites are present in the W. somnifera leaves, and 29 among these found in its roots and leaves are chiefly steroidal compounds, steroidal lactones, alkaloids, amino acids, etc. In addition, the whole shrub parts possess various medicinal activities s

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Kumar, Ravi, Rajat Dhariwal, Anurag Kumar, and Miss Minata. "Effect of Withania Somnifera (L.) root extract\'s on PC12 induced by hydrogen peroxide, study." Journal of Pharmaceutical and Biological Sciences 10, no. 2 (2023): 79–82. http://dx.doi.org/10.18231/j.jpbs.2022.015.

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The L. is also used as a crude medicament that mostly effected in various neurological and immunological disorders. It is also known as Ashwagandha and “Indian ginseng” in Indian region. There is a lack of information on the possible neuroprotective properties of W. somnifera root against HO- and Ab(1-42)-induced cytotoxicity, which are now targeted for innovative treatments for dementia, particularly dementia of the Alzheimer's type (AD). According to this research, we prepared an aqueous extract of dried roots of W. somnifera that possess the protective effect against Ab- aggregated fibril a

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Shrivastava, A.K. Upadhyay V.B. Gautam D.S. Sarvade S. and Sahu R.K. "Effect of integrated nutrient management on growth and productivity of Withania somnifera (L.) Dunal in Kymore Plateau and Satpura hills of Madhya Pradesh, India." Archives of Agriculture and Environmental Science 3, no. 2 (2018): 202–8. https://doi.org/10.26832/24566632.2018.0302015.

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The field experiment was carried out at the Dusty Acres Farm, Jawaharlal Nehru Krishi Vishwa Vidyalaya (JNKVV), Jabalpur, Madhya Pradesh to study the effect of integrated nutrient management for growth and yield of <em>Withania somnifera </em>(L.) Dunal (Variety: Jawahar Ashwagandha-134). Tallest plants (49.35 cm) were observed at harvest stage, whereas higher number of branches per plant (5.78) of <em>W. somnifera </em>was observed at 90 DAS with T11, respectively. The mean number of leaves per plant (125.40) and LAI (10.345) of <em>W. somnifera </em>was higher a

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Ratti, Neelima, and Avinash Upadhyay. "Influence of Glomus intraradices on growth, biochemical changes and withanolides content of Withania somnifera L Dunal (Ashwagandha)." Environment Conservation Journal 14, no. 1&2 (2013): 75–80. http://dx.doi.org/10.36953/ecj.2013.141213.

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Withania somnifera L. Dunal (Ashwagandha) also known as Indian ginseng, of the family Solanaceae is an important ancient medicinal plant, used in the Indian traditional system of medicine. The medicinal importance of W. somnifera is attributed to the presence of steroidal lactones called withanolides which are present in the leaves and roots of the herb. The present set of pot experiment was designed to investigate the effect of Glomus intraradices inoculation on growth, biochemical parameters and withanolides content of W. somnifera. The results showed significant enhancement on plant growth,

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Sabir, Farzana, Anil Kumar, Pragya Tiwari, et al. "Bioconversion of Artemisinin to its Nonperoxidic Derivative Deoxyartemisinin through Suspension Cultures of Withania somnifera Dunal." Zeitschrift für Naturforschung C 65, no. 9-10 (2010): 607–12. http://dx.doi.org/10.1515/znc-2010-9-1013.

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Biotransformation of artemisinin was investigated with two different cell lines of suspension cultures of Withania somnifera. Both cell lines exhibited potential to transform artemisinin into its nonperoxidic analogue, deoxyartemisinin, by eliminating the peroxo bridge of artemisinin. The enzyme involved in the reaction is assumed to be artemisinin peroxidase, and its activity in extracts of W. somnifera leaves was detected. Thus, the non-native cell-free extract of W. somnifera and suspension culture-mediated bioconversion can be a promising tool for further manipulation of pharmaceutical com

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Gaurav, Isha, Tanuja Singh, Abhimanyu Thakur, et al. "Synthesis, In-Vitro and In-Silico Evaluation of Silver Nanoparticles with Root Extract of Withania somnifera for Antibacterial Activity via Binding of Penicillin-Binding Protein-4." Current Pharmaceutical Biotechnology 21, no. 15 (2020): 1674–87. http://dx.doi.org/10.2174/1389201021666200702152000.

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Background: Metal Nanoparticles (NPs) have been widely used for various applications in biomedical sciences, including in drug delivery, and as therapeutic agents, but limited owing to their toxicity towards the healthy tissue. This warrants an alternative method, which can achieve the desired activity with much reduced or no toxicity. Being a biological product, Withania somnifera (W. somnifera) is environment friendly, besides being less toxic as compared to metal-based NPs. However, the exact mechanism of action of W. somnifera for its antibacterial activities has not been studied so far. O

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Nagappan, Arulkumar, Nithya Karunanithi, Sundareswaran Sentrayaperumal, et al. "Comparative Root Protein Profiles of Korean Ginseng (Panax ginseng) and Indian Ginseng (Withania somnifera)." American Journal of Chinese Medicine 40, no. 01 (2012): 203–18. http://dx.doi.org/10.1142/s0192415x12500164.

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Ginsenosides and withanolides are the secondary metabolites from Panax ginseng and Withania somnifera, respectively. These compounds have similar biological properties. Two-dimensional electrophoresis (2-DE) analysis was utilized to reveal the protein profile in the roots of both plants, with the aim of clarifying similarly- and differentially-expressed proteins. Total proteins of Korea ginseng (P. ginseng) and Indian ginseng (W. somnifera) roots were separated by 2-DE using a pH 4–7 immobilized pH gradient strip in the first dimension and 12% sodium dodecyl sulfate polyacrylamide gel electrop

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Devaraj Reddy KN, Srilakshmi Aluri, Prathvi Shetty, et al. "Assessing the Efficacy and Biological Benefits of Withanolide-rich Withania somnifera Root Extract." Annual Research & Review in Biology 39, no. 5 (2024): 54–64. http://dx.doi.org/10.9734/arrb/2024/v39i52081.

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The medicinal plant Withania somnifera, usually referred to as Ashwagandha, is a member of the Solanaceae family. The presence of Withanolides in the roots is responsible for a number of pharmacological effects in Ashwagandha. Withanolides have been demonstrated to be an effective neuronal, immune, anti-stress, and anti-cancer agent. However, Withanolides demonstrated limited permeability, lowering the bioavailability and efficacy of active compounds. The goal of the study was to ascertain the biological efficacy of Ashwagandha Composition, a blend of W. somnifera milk extract and water extrac

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Mikhaylova, E. V. "Prospects for the application of the medicinal plant Withania somnifera for biotechnological production of pharmaceuticals." Biomics 14, no. 3 (2022): 192–208. http://dx.doi.org/10.31301/2221-6197.bmcs.2022-14.

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Withania somnifera (L.) Dunal, also known as ashwagandha or Indian ginseng, is widely used in traditional oriental medicine. Modern research confirms the applicability of withanolides and other compounds from withania roots in treatment of various diseases. However, the massive gathering of W. somnifera for the purposes of traditional medicine puts the species at risk of extinction. Since this plant is sensitive to climatic conditions, production of W. somnifera hairy root cultures in bioreactors is the most promising cultivation method. This method allows to produce biomaterial of high purity

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Alsabaa, Zein Husam, Luay Abu-Qatouseh, Kenza Mansoor, et al. "Pharmacokinetic and pharmacodynamic effects of Withania somnifera (L.) Dunal (ashwagandha) and carbamazepine combination in rats." Journal of Pharmacy & Pharmacognosy Research 13, no. 3 (2025): 925–32. https://doi.org/10.56499/jppres24.2088_13.3.925.

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Context: Withania somnifera, also known as ashwagandha, has antibacterial, anti-inflammatory, anticonvulsant, and anti-diabetic properties and reduces stress. Carbamazepine is one of the most used antiepileptic medications for treating epilepsy. Aims: To investigate the pharmacokinetics and pharmacodynamics of carbamazepine versus W. somnifera extract combination in vivo in healthy rat plasma using high-performance liquid chromatography. Methods: The carbamazepine levels were analyzed using validated high-performance liquid chromatography. The gamma-aminobutyric acid in the serum was performed

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Thakur, Komal, Pankaj Verma, Isha Agrawal, Manish Vyas, and Sanjeev Kumar Sahu. "In-silico molecular docking for Potential herbal leads from Withaniasomnifera L. Dunal for the treatment of Alzheimer’s disease." BIO Web of Conferences 86 (2024): 01043. http://dx.doi.org/10.1051/bioconf/20248601043.

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Alzheimer's disease (AD) poses a significant global health challenge, necessitating novel therapeutic interventions. Withaniasomnifera L. Dunal, commonly known as Ashwagandha, has been historically utilized in traditional medicine for its neuroprotective properties. This study employs computational techniques to explore the potential of W. somnifera compounds in targeting key proteins associated with AD. The reported phytoconstituents of W. somnifera were identified and subjected to molecular docking studies against 5NUU (Torpedo californica acetylcholinesterase in complex with a chlorotacrine

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Munir, Naveed, Zahed Mahmood, Muhammad Shahid, et al. "Withania somnifera Chemical Constituents’ In Vitro Antioxidant Potential and Their Response on Spermatozoa Parameters." Dose-Response 20, no. 1 (2022): 155932582210749. http://dx.doi.org/10.1177/15593258221074936.

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Background: Phytomedicine is becoming more acceptable as an alternative medicinal approach in the modern era. Objectives: The current study examined the antioxidant capacity and in vitro response of phytochemical constituents of Withania somnifera (Ashwagandha) on standard parameters of healthy volunteer semen. Methods: The phytochemicals and their pharmacological response in a hydroethanolic (30:70 v/v) extract of W. somnifera roots were determined using standard protocols. Results: The constituents included flavonoids, phenolic acids, alkaloids, and terpenoids were reported. High-performance

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Sultana, Rajia, and Md Zakir Sultan. "In vitro Effect of Withania somnifera, Mucuna pruriens and Pausinystalia johimbe on Hepatic Cytochrome P450 in Rat." Bangladesh Pharmaceutical Journal 21, no. 2 (2018): 118–22. http://dx.doi.org/10.3329/bpj.v21i2.37922.

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The effect of Withania somnifera, Mucuna pruriens and Pausinystalia johimbe extracts on hepatic cytochrome P450 enzyme CYP3A4 activities was studied using rat liver microsomes. CYP3A4- dependent testosterone 6β-hydroxylation activities were determined by ELISA. In the study, rats were treated with W. somnifera (0.5 g/kg/day), M. pruriens (0.5 g/kg/day) and P. johimbe (0.25 g/kg/day) extracts for 20 days. It was found that W. somnifera, M. pruriens and P. johimbe extracts showed potent to moderate inhibitory effect on CYP3A4 activities in rat liver microsomes, with IC50 values of 18.01 ng/mL, 1

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Rege, A. A., P. R. Juvekar, and A. R. Juvekar. "IN VITRO LIPID PEROXIDATION INHIBITORY AND ANTI-ARTHRITIC ACTIVITIES OF SOME INDIAN MEDICINAL PLANTS." INDIAN DRUGS 49, no. 06 (2012): 31–35. http://dx.doi.org/10.53879/id.49.06.p0031.

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Anti-lipid peroxidation effect of aqueous extracts of Ocimum sanctum, Tinospora cordifolia and Withania somnifera was evaluated against Fe2+-ascorbic acid-induced lipid peroxidation using rat liver mitochondria as model system, whereas, anti-arthritic activity was evaluated by proteinase inhibitory assay. O. sanctum showed potent anti-lipid peroxidation and anti-arthritic activities. T. cordifolia exhibited moderate anti-lipid peroxidation activity, but considerable anti-arthritic activity, whereas, W. somnifera revealed least lipid peroxidation inhibitory activity and considerable anti-arthri

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Biczak, Emilia, Oliwia Biegańska, Grzegorz Przywara, Klaudia Suchańska, Krzysztof Gadzalski, and Julita Kulbacka. "Adaptogens as adjuvants in cancer treatment: searching for synergy with conventional therapies." Farmacja Polska 80, no. 3 (2024): 173–87. http://dx.doi.org/10.32383/farmpol/191383.

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Adaptogeny to grupa roślinnych surowców lub substancji w nich zawartych, stosowanych w medycynie naturalnej i suplementacji. Mają one właściwości zwiększające odporność organizmu oraz pomagają w utrzymaniu homeostazy. Działanie adaptogenów związane jest z modulacją procesów na poziomie genetycznym, białkowym i metabolicznym, dzięki czemu mogą chronić organizm przed stresem oksydacyjnym, stymulować odpowiedź immunologiczną oraz hamować proliferację komórek nowotworowych. Liczne badania in vivo oraz in vitro wykazały, że adaptogeny mogą być skuteczne jako adiuwanty w chemioterapii nowotworów. W

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Alsuhaimi, Nadia Mohammad, Mohammad Ajmal Ali, Mona Solaiman Alwahibi, et al. "Complete chloroplast genome sequence of a novel Withania somnifera (L.) Dunal: Comparative genomics and phylogenetic insights." Bangladesh Journal of Plant Taxonomy 31, no. 2 (2024): 205–23. https://doi.org/10.3329/bjpt.v31i2.78749.

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This study introduces a novel variety of the highly esteemed medicinal plant Withania somnifera (L.) Dunal from the family Solanaceae. The new variety, Withania somnifera var. abhaica Nadia, A. Ali & M.S. Alwahibi, var. nov., is distributed at high altitudes in the Abha hills of Saudi Arabia. The distinct characteristics of the novel variety of W. somnifera include elliptic-elongated leaves that are thick and semi-succulent in nature, and a fruiting calyx with a bifurcated tip measuring approximately 0.5 mm in length, with each bifurcated tip being botuliform in shape. Using next-generatio

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R, Kundra, S. S. Samant, SK Nandi, and RK Sharma. "Investigation of antioxidant properties of Withania somnifera (L.) Dunal and influence of physico-chemical properties of soil along the topographic gradients in sub-tropical region of the Indian Himalaya." International Journal of Phytomedicine 9, no. 3 (2017): 407. http://dx.doi.org/10.5138/09750185.1986.

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<p>A high value medicinal plant <em>W. somnifera </em>L. Indian Ginseng; Ashwagandha investigated for the antioxidant and influence of physico-chemical properties of soil on antioxidant along the topographical gradients in Kullu Valley, North Western Indian Himalaya. Total phenolic and flavonoid contents in methanol extracts of fruits, leaves, stems and roots were quantified and their antioxidant activities were evaluated using the <em>in-vitro</em> assays such as DPPH, ABTS and FRAP. The study revealed that fruits, leaves, stems and roots of <em>W. somnifer

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Kushwaha, Vimlesh. "Nephroprotection of Withania somnifera root extract against gentamicin induced nephrotoxicity: a histological evaluation in experimental Wistar rats." International Journal of Basic & Clinical Pharmacology 8, no. 10 (2019): 2297. http://dx.doi.org/10.18203/2319-2003.ijbcp20194275.

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Background: Gentamicin, an aminoglycoside group of drug, used against aerobic gram negative bacteria, is known for nephrotoxicity. Herbal products have a special place in the world of pharmaceuticals with their safety, efficacy and cost effectiveness. Withania somnifera (Ashwagandha) roots had known since long for its antioxidant status and free radical scavenging property. So W. somnifera can be used as nephroprotective agent because of free radical scavenging property.Methods: Total 54 rats were randomised in 3 groups named G10, G20 and G30 according to 10, 20 and 30 days of treatment. In ea

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Obidowska, Grażyna, and Ala Sadowska. "Wpływ pH podłoża i jego zasobności w azot na plonowanie Withania somnifera (L.) Dun." Biuletyn Instytutu Hodowli i Aklimatyzacji Roślin, no. 228 (September 30, 2003): 373–81. https://doi.org/10.37317/biul-2003-0121.

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Withania somnifera, subtropikalna roślina z rodziny Solanaceae, jest bardzo interesującym gatunkiem leczniczym. W rejonach naturalnego występowania, a zwłaszcza w Indiach, od wieków wykorzystuje się jej korzeń (Radix Withaniae) jako środek pobudzający siły życiowe, działający tonizująco, przysparzający energii witalnej, zwiększający odporność na choroby i niekorzystny wpływ otoczenia. Doświadczenia uprawowe, przeprowadzone w szklarni SGGW w Ursynowie w latach 1997–1999, miały potwierdzić bądź obalić hipotezę, że obserwowany w Indiach brak reakcji witanii na azot nie jest wynikiem znikomego zap

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Kalpana, Kriti, Shen Yap, Moriya Tsuji, and Akira Kawamura. "Molecular Mechanism behind the Safe Immunostimulatory Effect of Withania somnifera." Biomolecules 13, no. 5 (2023): 828. http://dx.doi.org/10.3390/biom13050828.

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Withania somnifera (L.) Dunal (family Solanaceae) is a medicinal plant known for, among many pharmacological properties, an immune boosting effect. Our recent study revealed that its key immunostimulatory factor is lipopolysaccharide of plant-associated bacteria. This is peculiar, because, although LPS can elicit protective immunity, it is an extremely potent pro-inflammatory toxin (endotoxin). However, W. somnifera is not associated with such toxicity. In fact, despite the presence of LPS, it does not trigger massive inflammatory responses in macrophages. To gain insights into the safe immuno

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Gupta, Lalita, and Meera Srivastava. "EFFECT OF WITHANIA SOMNIFERA EXTRACTS ON THE MORTALITY OF CALLOSOBRUCHUS CHINENSIS L." Journal of Biopesticides 01, no. 02 (2008): 190–92. http://dx.doi.org/10.57182/jbiopestic.1.2.190-192.

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ABSTRACT The present study was undertaken to study the effect of different extracts (agueous suspension, ether and water) of various parts of Withania somnifera (Solanaceae) against Callosobruchus chinensis L. A maximum of 63.33% adult mortality was observed in C.chinensis treated with 10% ether extracts of W. somnifera root.

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Ahmad, Muzamil, Sofiyan Saleem, Abdullah Shafique Ahmad, et al. "Neuroprotective effects of Withania somnifera on 6-hydroxydopamine induced Parkinsonism in rats." Human & Experimental Toxicology 24, no. 3 (2005): 137–47. http://dx.doi.org/10.1191/0960327105ht509oa.

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6-Hydroxydopamine (6-OHDA) is one of the most widely used rat models for Parkinson's disease. There is ample evidence in the literature that 6-OHDA elicits its toxic manifestations through oxidant stress. In the present study, we evaluated the anti-parkinsonian effects of Withania somnifera extract, which has been reported to have potent anti-oxidant, anti-peroxidative and free radical quenching properties in various diseased conditions. Rats were pretreated with 100, 200 and 300 mg/kg b.w. of the W. somnifera extract orally for 3 weeks. On day 21, 2 mL of 6-OHDA (10 mg in 0.1% in ascorbic aci

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Parhar, Manreet, and Parveen Bansal. "Development of a High Penetration Safe Irrigant from Withania somnifera." International Journal of Applied & Basic Medical Research 13, no. 3 (2023): 149–52. http://dx.doi.org/10.4103/ijabmr.ijabmr_89_23.

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Background: Herbal medicine is regaining a strong position in health care by virtue of better safety and minimal toxicity as compared to conventional chemotherapies. It is making a place in dental care in the form of various toothpastes, lotions, and mouthwashes. It has been analyzed that very few discrete herbal irrigants have an action comparable to that of sodium hypochlorite. No data about any study on penetration depth and penetration area for herbal-based irrigants used in root canal treatment are available. Aim: The aim of this study was to assess the efficacy of Withania somnifera extr

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Obidowska, Grażyna, and Ala Sadowska. "Próby uprawy polowej Withania somnifera (L.) Dun. oraz ocena plonu i wartości surowca krajowego." Biuletyn Instytutu Hodowli i Aklimatyzacji Roślin, no. 233 (September 30, 2004): 173–80. https://doi.org/10.37317/biul-2004-0046.

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W rejonach subtropikalnych, a zwłaszcza w Indiach, od wieków wykorzystuje się korzeń Withania somnifera (L.) Dun. (Withaniae radix) jako środek adaptogenny: zwiększający odporność i wzmagający siły witalne organizmu. Celem niniejszej pracy była ocena plonu i wartości surowca zielarskiego (ziele i korzenie) uzyskanego przy kilku wariantach uprawy Withania somnifera (L.) Dun. w gruncie, w warunkach klimatu umiarkowanego. Porównano plon korzeni, ziela oraz zawartość i plon witaferyny A osiągnięte przy uprawie z siewu do gruntu i przy uprawie z rozsady, a następnie 10 wariantów uprawy z rozsady ró

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SHUKLA, A., S. SRIVASTAVA, and K. DEV. "Review on chemistry, pharmacology, toxicity and future prospectives of withaferin A." Journal of Medicinal and Aromatic Plant Sciences 45, no. 3 (2023): 108–22. http://dx.doi.org/10.62029/jmaps.v45i3.shukla.

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The medicinal plant Withania somnifera is widely researched for its antiinflammatory,cardioprotective, and anticancer effects. W. somnifera preparations are specifically used to treat menstruation issues and arthritis in Ayurveda, the main traditional Indian medical system. The bioactive substance withaferin A (WA), a steroidal lactone, was first isolated from the leaves of W. somnifera. Numerous studies showed that WA contains various pharmacological properties, making it a good choice for treating various diseases. Its structural modification targets several signal transduction pathways and

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Stoev, S. D., P. Njobeh, I. Zarkov, et al. "Selected herbal feed additives showing protective effects against ochratoxin A toxicosis in broiler chicks." World Mycotoxin Journal 12, no. 3 (2019): 257–68. http://dx.doi.org/10.3920/wmj2019.2432.

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The protective effects of herbal feed additives Silybum marianum, Withania somnifera and Centella asiatica against the toxic effects of ochratoxin A (OTA) were studied in 70 broiler chicks aged from 11 to 42 days. OTA was given with the feed at levels 5 mg/kg, whereas S. marianum, W. somnifera and C. asiatica were given at levels of 1,100, 4,000 and 4,600 mg/kg, respectively. All chicks were immunised at the age of 14 days against Newcastle disease. A protective effect of all studied herbal additives against the immunosuppressive effect of OTA and associated biochemical or pathomorphological c

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Deshpande, Sanjay H., Abdullatif Bin Muhsinah, Zabin K. Bagewadi, et al. "In Silico Study on the Interactions, Molecular Docking, Dynamics and Simulation of Potential Compounds from Withania somnifera (L.) Dunal Root against Cancer by Targeting KAT6A." Molecules 28, no. 3 (2023): 1117. http://dx.doi.org/10.3390/molecules28031117.

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Cancer is characterized by the abnormal development of cells that divide in an uncontrolled manner and further take over the body and destroy the normal cells of the body. Although several therapies are practiced, the demand and need for new therapeutic agents are ever-increasing because of issues with the safety, efficacy and efficiency of old drugs. Several plant-based therapeutics are being used for treatment, either as conjugates with existing drugs or as standalone formulations. Withania somnifera (L.) Dunal is a highly studied medicinal plant which is known to possess immunomodulatory ac

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Moustafa, Enas Mahmoud, Hemat Sameeh Abdel Salam, and Somaya Zakaria Mansour. "Withania somnifera Modulates Radiation-Induced Generation of Lung Cancer Stem Cells via Restraining the Hedgehog Signaling Factors." Dose-Response 20, no. 1 (2022): 155932582210767. http://dx.doi.org/10.1177/15593258221076711.

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Cancer stem cells (CSCs) are implicated in the genesis, development, and recurrence of lung cancer (LC) with great resistance to radiation and chemotherapy. The aim of this study is to assess the inhibitory potential of ethanol extract of Withania somnifera (WS); 500 mg/kg body-weight/day and 8 Gy of ionizing radiation (IR) could inhibit the stemness gene and confer the radiosensitizing effect of W. somnifera extract in the female rat LC model. Compared to IR or WS, the in vitro assay showed that WS + IR potentiates proliferation-inhibition and cell death of the A-549 cell line and suppresses

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Cabey, Kadine, Dani M. Long, Alexander Law, et al. "Withania somnifera and Centella asiatica Extracts Ameliorate Behavioral Deficits in an In Vivo Drosophila melanogaster Model of Oxidative Stress." Antioxidants 11, no. 1 (2022): 121. http://dx.doi.org/10.3390/antiox11010121.

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Due to an increase in the aging population, age-related diseases and age-related changes, such as diminished cognition and sleep disturbances, are an increasing health threat. It has been suggested that an increase in oxidative stress underlies many of these changes. Current treatments for these diseases and changes either have low efficacy or have deleterious side effects preventing long-time use. Therefore, alternative treatments that promote healthy aging and provide resilience against these health threats are needed. The herbs Withania somnifera and Centella asiatica may be two such altern

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Balkrishna, Acharya, Pradeep Nain, Anshul Chauhan та ін. "Super Critical Fluid Extracted Fatty Acids from Withania somnifera Seeds Repair Psoriasis-Like Skin Lesions and Attenuate Pro-Inflammatory Cytokines (TNF-α and IL-6) Release". Biomolecules 10, № 2 (2020): 185. http://dx.doi.org/10.3390/biom10020185.

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(1) Background: Withania somnifera Dunal (Ashwagandha) is a widely used medicinal herb in traditional medicinal systems with extensive research on various plant parts. Surprisingly, seeds of W. somnifera have never been investigated for their therapeutic potential. (2) Methods: W. somnifera seeds were extracted for fatty acids (WSSO) using super critical fluid extraction, and was analyzed by gas chromatography. Its therapeutic potential in psoriasis-like skin etiologies was investigated using a 12-O tetradecanoyl phorbol 13-acetate (TPA)-induced psoriatic mouse model. Psoriatic inflammation al

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Mikhaylova, E. V., and I. M. Palkina. "Problems of genetic identification of economically valuable plants of the genus Withania." Biomics 16, no. 3 (2024): 328–34. http://dx.doi.org/10.31301/2221-6197.bmcs.2024-21.

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Representatives of the genus Withania of the Solanaceae family, the plants Withania somnifera and Withania coagulans Dunal. are valuable for the pharmaceutical and food industries due to the content of biologically active compounds, mainly belonging to the class of withanolides. Powdered dried roots of W. somnifera are used as dietary supplements. In addition to climatic conditions and soil composition, plant metabolism is affected by the genotype. The external similarity of W. somnifera and W. coagulans may also lead to accidental or intentional substitution of one species for the other. We a

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Negi, M. S., A. Singh, and M. Lakshmikumaran. "Genetic variation and relationship among and within Withania species as revealed by AFLP markers." Genome 43, no. 6 (2000): 975–80. http://dx.doi.org/10.1139/g00-073.

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Withania somnifera is an important medicinal plant, and its anticancerous properties have been attributed to various classes of withanolide compounds. The objective of the present study was to investigate the inter- and intraspecific genetic variation present in 35 individuals of W. somnifera and 5 individuals of W. coagulans using AFLP (amplified fragment length polymorphism) marker technique. The information about genetic variation determined from AFLP data for 40 individuals was employed to estimate similarity matrix value based on Jaccard's coefficient. The similarity values were further u

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Lee, Bum Soo, Min Jeong Yoo, Heesun Kang, et al. "Withasomniferol D, a New Anti-Adipogenic Withanolide from the Roots of Ashwagandha (Withania somnifera)." Pharmaceuticals 14, no. 10 (2021): 1017. http://dx.doi.org/10.3390/ph14101017.

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Withania somnifera (Solanaceae), well-known as ‘Indian ginseng’ or ‘Ashwagandha’, is a medicinal plant that is used in Ayurvedic practice to promote good health and longevity. As part of an ongoing investigation for bioactive natural products with novel structures, we performed a phytochemical examination of the roots of W. somnifera employed with liquid chromatography–mass spectrometry (LC/MS)-based analysis. The chemical analysis of the methanol extract of W. somnifera roots using repeated column chromatography and high-performance liquid chromatography under the guidance of an LC/MS-based a

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Jha, Sanjeev Kumar, and Dilip Kumar Paul. "Efficacy of Withania somnifera on lipid profile of endosulfan induced toxicity in Swiss albino mice." Journal of Applied and Natural Science 12, no. 3 (2020): 454–59. http://dx.doi.org/10.31018/jans.v12i3.2354.

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India is an agrarian country with crops cultivated at a huge scale. Pesticides in recent times have caused serious health hazards in the population which are widely used by the farmers for the better yield of crops. Endosulfan is an organochlorine pesticide, which is widely used by the farmers. But, in the present times, it has caused serious health hazards in the exposed population causing various diseases, including cancer. Hence, the present study on animal aims to observe the protective effect of Withania somnifera against endosulfan induced toxicity in Swiss albino mice. Endosulfan at the

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Gebeyehu, Amsalu Genanaw, Kumlachew Zelalem Walle, Meseret ZEbeaman Birhanu, and Rahel Gebeyehu. "Structural Elucidation and Antibacterial Activity Studies of Leaf Extracts of <i>Withania somnifera</i>." Indonesian Journal of Chemistry 22, no. 6 (2022): 1586. http://dx.doi.org/10.22146/ijc.74750.

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Withania somnifera (W. somnifera), a small, woody shrub in the Solanaceae family, has been studied using a phytochemical test, antibacterial activity and partial characterizations. Air-dried and powdered leaves of the plant were extracted with maceration over an electrical shaker using the solvent chloroform and methanol. After crude extracts of the plant were concentrated, the diffusion antibacterial susceptibility test was carried out on 25, 50, 75, and 100 mg/mL of chloroform and methanol crude extract. The bacteria used were S. aureus, S. pneumonia, E. coli, and S. typhi. Each antibacteria

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Paulraj, Prabhavathi, Sankareswaran Muruganantham, Anbalagan S, Manikandan A, and Karthikeyan G. "GREEN SYNTHESIS AND CHARACTERIZATION OF SILVER NANOPARTICLES FROM WITHANIA SOMNIFERA (L.) DUNAL." Asian Journal of Pharmaceutical and Clinical Research 9, no. 5 (2016): 34. http://dx.doi.org/10.22159/ajpcr.2016.v9i5.13204.

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ABSTRACTThe metal nanoparticle synthesis is highly explored the field of nanotechnology. The biological methods seem to be more effective because of slowreduction rate and polydispersity of the final products. The main aim of this study is too the rapid and simplistic synthesis of silver nanoparticlesby Withania somnifera Linn. at room temperature. The exposure of reaction mixtures containing silver nitrate and dried leaf powder of W. somniferaresulted in reduction of metal ions within 5 minutes. The extracellular synthesized silver nanoparticles were characterized by ultraviolet-visible,infra

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Purohit, Abhilasha, and Ashok Purohit. "ELTROXIN LIKE MIMIC ACTION OF WITHANIA SOMNIFERA LEAF EXTRACT IN HYPOTHYROID-INDUCED RATS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 11 (2018): 280. http://dx.doi.org/10.22159/ajpcr.2018.v11i11.27424.

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Objective: The present study was designed to examine the anti-hypothyroid activity of Withania somnifera (Ashwagandha)’s leaf extract on 6-n-propyl- 2-thio-uracil (PTU) induced hypothyroid rats.Method: Ethanolic extracts of W. somnifera leaf and Eltroxin were administrated to PTU induced hypothyroid rats. The animals were divided into control, PTU treatment, W. somnifera leaf extract treatment, and Eltroxin treatment groups for 60 days. The serum T3 and T4 were estimated, and biochemical and hematological parameters of the blood serum were also evaluated.Results: PTU induction caused a signifi

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Lungu, Petru Fabian, and Alin Ciobica. "A current review for some methodological aspects on using Crocus sativus and Whitania somnifera sp. extracts in the treatment of schizophrenia." Romanian Biotechnological Letters 28, no. 1/2023 (2023): 3835–40. http://dx.doi.org/10.25083/rbl/28.1/3835.3840.

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Schizophrenia is a severe mental illnes that affects population all around the world which poses a problem for the abilities of the affected person as well as their family members. Aim of the study: This narrative review has as its objective the potential evaluation of treatment with extracts from Crocus sativus and Whitania somnifera on patients with schizophrenia. Results: The plant extracts C. sativus and W. somnifera have a very well developed extraction method and beneficial effects in the case of patients with schizophrenia. Conclusion: Crocus sativus and Whitania somnifera extracts coul

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Meenatchisundaram, Subramani, Sindhu P, and Veerapandian Thangapandian. "Evaluation of Neutralizing Efficacy of Acorus calamus and Withania somnifera Root Extracts Against Bangarus caeruleus Venom." Biological Sciences - PJSIR 54, no. 3 (2011): 157–62. http://dx.doi.org/10.52763/pjsir.biol.sci.54.3.2011.157.162.

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Acorus calamus and Withania somnifera root extracts when tested against Bangarus caeruleus venom, both the plant extracts neutralized various pharmacological activities induced by B. caeruleus venom. About 0.12 mg of A. calamus and 0.15 mg of W. somnifera root extracts completely neutralized the lethal activity of 2LD50 of B. caeruleus venom. Various pharmacological activities like haemorrhagic, coagulance, edematic, fibrionlytic and phospholipase activities were effectively neutralized by both the extracts.

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Gayozo, Elvio, Laura Rojas, and Liz Castro. "Acoplamiento molecular entre la proteína viral 1 del virus de la enfermedad infecciosa Bursal y fitoconstituyentes de Withania somnifera (L.) Dunal: Un enfoque computacional." Revista de Investigaciones Veterinarias del Perú 33, no. 5 (2022): e22022. http://dx.doi.org/10.15381/rivep.v33i5.22022.

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La enfermedad infecciosa bursal es una patología de origen viral que afecta a aves de corral ocasionando una alta tasa de mortalidad. Las vacunas existentes se enfrentan al problema de la aparición de nuevas cepas, por lo que se realizan búsquedas de moléculas con potencial afinidad de unión a proteínas virales. El extracto de Withania somnífera interviene en la replicación del virus de la bursitis infecciosa, pero el posible mecanismo de acción no es bien conocido. El objetivo de este estudio fue identificar a través de métodos in silico los fitoconstituyentes de W. somnifera con afinidad de

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K.C., Binita, and Gandhiv Kafle. "Assessment of end products of Ashwagandha (Withania somnifera) and their marketing channel in Bharatpur, Chitwan, Nepal." Journal of Agriculture and Natural Resources 7, no. 1 (2024): 37–49. https://doi.org/10.3126/janr.v7i1.73123.

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This study was conducted for six month from February-July in 2019 to evaluate the end products, end uses, ingredients and marketing channel associated with Ashwagandha (Withania somnifera) in Bharatpur, Chitwan, Nepal. A 100% sampling intensity was employed encompassing all medicinal/herbal retailer shops and processing industries/companies identified within the study area. Data were collected through complete surveys of herbal/medicinal shops and industries located at Bharatpur city by using structured questionnaire which offered 41 end products containing W. somnifera as an ingredient. Addit

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LİNGFA, Lali, Aravinda TİRUMALA, and Srinivas ANKANAGARİ. "GC-MS profiling of anticancer and antimicrobial phytochemicals in the vegetative leaf, root, and stem of Withania somnifera (L.) Dunal." International Journal of Secondary Metabolite 11, no. 1 (2023): 63–77. http://dx.doi.org/10.21448/ijsm.1256932.

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Withania somnifera has been used for a long time in traditional medicine. Its crude extract, dried powder, and purified metabolites from mature plants have shown promising therapeutic potential. To further investigate its potential, the detection of phytochemicals with anticancer and antimicrobial properties in the vegetative stage is essential. Hence, this study was done to identify phytochemical constituents using GC-MS analysis for anticancer and antimicrobial activities in the vegetative stage from methanolic extracts of stem, leaf, and root in W. somnifera. The air-dried plant parts were

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EL-Hefny, Mervat, Mohamed Z. M. Salem, Said I. Behiry, and Hayssam M. Ali. "The Potential Antibacterial and Antifungal Activities of Wood Treated with Withania somnifera Fruit Extract, and the Phenolic, Caffeine, and Flavonoid Composition of the Extract According to HPLC." Processes 8, no. 1 (2020): 113. http://dx.doi.org/10.3390/pr8010113.

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In the present study, Melia azedarach wood blocks treated with different acetone extract concentrations from Withania somnifera fruits are assessed for their antibacterial and anti-fungal activities. Wood blocks of M. azedarach treated with W. somnifera fruit extract at concentrations of 0, 1, 2, and 3% are evaluated for in vitro antimicrobial activity against five genbank accessioned bacterial strains—Agrobacterium tumefaciens, Dickeya solani, Erwinia amylovora, Pseudomonas cichorii, and Serratia pylumthica—and two fungi, namely, Fusarium culmorum and Rhizoctonia solani. Through HPLC analysis

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