Relevant bibliographies by topics / Wag/Rij

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Academic literature on the topic 'Wag/Rij'

Author: Grafiati
Published: 11 March 2023
Last updated: 31 July 2025

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Journal articles on the topic "Wag/Rij"

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Abbasova, К. R., S. М. Kuzhuget, and Е. Т. Tsyba. "Behavioural and electrophysiological features of WAG/Rij rats with different forms of genetic epilepsy." Rossijskij fiziologičeskij žurnal im. I.M. Sečenova 110, no. 10 (2024): 1733–51. https://doi.org/10.31857/s0869813924100116.

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WAG/Rij rats are widely used as a genetic model of absence epilepsy. Approximately 15–50% rats of the strain are susceptible to audiogenic seizures. WAG/Rij rats demonstrate depressive-like behavior. After preliminary sound provocation an increased level of anxiety was found in audiogenic susceptible WAG/Rij subgroup. Electrophysiological and behavioral studies suggest the involvement of the dopaminergic system in both absence and audiogenic epilepsy. An increased binding density to dopamine receptors was found in the dorsal striatum subregions in audiogenic prone rats compared to non-audiogen
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Габова, А. В., К. Ю. Саркисова, Е. А. Федосова, А. Б. Шацкова та А. А. Морозов. "ВОЗРАСТНЫЕ ИЗМЕНЕНИЯ ПИК-ВОЛНОВЫХ РАЗРЯДОВ У КРЫС ЛИНИИ WAG/Rij С ГЕНЕТИЧЕСКОЙ АБСАНСНОЙ ЭПИЛЕПСИЕЙ, "Российский физиологический журнал им. И.М. Сеченова"". Российский физиологический журнал им. И. М. Сеченова, № 10 (2018): 1176–89. http://dx.doi.org/10.7868/s0869813918100052.

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Крысы линии WAG/Rij являются моделью генетической абсансной эпилепсии, характеризующейся наличием пик-волновых разрядов (ПВР) на ЭЭГ. Известно, что первые ПВР у крыс линии WAG/Rij возникают в возрасте 2-3 месяцев, а в дальнейшем их число и длительность увеличиваются. Однако эволюция ПВР в процессе прогрессивного развития абсансной эпилепсии у крыс линии WAG/Rij остается неисследованной. Цель настоящей работы - выяснить возрастные изменения частотно-временной динамики, частотного спектра и морфологических характеристик ПВР у крыс линии WAG/Rij. Для достижения этой цели у одних и тех же крыс в в
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Zhuravlev, Maxim, Anastasiya Runnova, Kirill Smirnov, and Evgenia Sitnikova. "Spike-Wave Seizures, NREM Sleep and Micro-Arousals in WAG/Rij Rats with Genetic Predisposition to Absence Epilepsy: Developmental Aspects." Life 12, no. 4 (2022): 576. http://dx.doi.org/10.3390/life12040576.

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The current study was done in Wistar Albino Glaxo Rijswijk (WAG/Rij) rats, which are genetically prone to develop spontaneous spike-wave discharges (SWDs) and are widely used as a genetic model of absence epilepsy. Here, we examined functional links between sleep and spike-wave epilepsy in aging WAG/Rij rats using advanced techniques of EEG analysis. SWDs, periods of NREM sleep and micro-arousals were automatically detected in three-channel epidural EEG recorded in freely moving WAG/Rij rats consequently at the age 5, 7 and 9 months. We characterized the developmental profile of spike-wave epi
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Gabova, A. V., E. A. Fedosova, and K. Yu Sarkisova. "Spindles in WAG/Rij Rats with Absence Epilepsy and Comorbid Depression." Rossijskij fiziologičeskij žurnal im. I.M. Sečenova 110, no. 6 (2024): 1037–54. http://dx.doi.org/10.31857/s0869813924060115.

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WAG/Rij rats are a valid model of absence epilepsy and comorbid depression. We have previously shown that WAG/Rij rats have disturbances in the sleep-wake cycle and changes in the characteristics of sleep spindles. A negative correlation was also found between the number of spike-wave discharges (SWD) and the duration of rapid eye movement (REM) sleep. Clinical evidence suggests that the traditional antidepressants imipramine and fluoxetine are effective in suppressing symptoms of depression, but may have a negative impact on the sleep-wake cycle and comorbid epilepsy in patients. Our previous
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Ilbay, Gul, Aymen Balıkcı, Sibel Köktürk, et al. "Neonatal Tactile Stimulation Downregulates Dendritic Spines in Layer V Pyramidal Neurons of the WAG/Rij Rat Somatosensory Cortex." Neural Plasticity 2022 (April 12, 2022): 1–9. http://dx.doi.org/10.1155/2022/7251460.

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Objective. The aim of our study is to examine the effects of neonatal tactile stimulations on the brain structures that previously defined as the focus of epilepsy in the Wistar-Albino-Glaxo from Rijswijk (WAG/Rij) rat brain with genetic absence epilepsy. Methods. In the present research, morphology and density of dendritic spines were analyzed in layer V pyramidal neurons of the somatosensory cortex (SoCx) of WAG/Rij rats (nonstimulated control, tactile-stimulated, and maternal separated rats) and healthy Wistar (nonepileptic) rats. To achieve this, a Golgi-Cox method was used. Results. Dendr
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Musina, L. A., and A. I. Lebedeva. "Development of retinitis in WAG/Rij rats (Electron microscopic examination)." Modern technologies in ophtalmology 2, no. 4 (2024): 271–72. http://dx.doi.org/10.25276/2312-4911-2024-4-271-272.

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Актуальность. Разработка методов лечения любой патологии, в том числе и врожденных заболеваний сетчатки глаза, требует глубокого осмысления механизма их развития. Цель. Изучить ультраструктуру сетчатки глаза крыс линии WAG/Rij. Материал и методы. При помощи растрового электронного микроскопа JEM 1011 (Япония) исследована сетчатка глаз от 32 крыс линии WAG/Rij с рождения до их половозрелости. Результаты. В сетчатке крыс линии WAG/Rij ультраструктурные признаки дистрофических и деструктивных процессов начинают определяться к концу 3-й недели после рождения. Выявляется вакуолизация и деструкция н
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Dobryakova,*, Yulia, Vyacheslav Dubynin, and Gilles Luijtelaar. "The effect of haloperidol on maternal behavior in WAG/Rij rats and its consequences in the offspring." Acta Neurobiologiae Experimentalis 71, no. 3 (2011): 339–47. http://dx.doi.org/10.55782/ane-2011-1856.

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Haloperidol treatment during pre- and post-natal period affects maternal behavior and this may have long-term effects on the offspring. We examined whether early haloperidol administration to Wistar-Albino-Glaxo dams from Rijswijk (WAG/Rij) and in Wistar control rats would affect maternal care and as a consequence, seizure susceptibility and behavior in the WAG/Rij?s offspring at 3-4 months of age. Nursing dams of this well-validated genetic animal model of absence epilepsy and control dams were injected with haloperidol or saline at PPD 1 to 6. Maternal behavior was evaluated at PPD 7 to 9. H
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Musina, L. A., S. S. Baigil'din, and Z. R. Khismatullina. "Morphological study of the retina of WAG/Rij rats with pigmentary degeneration in postnatal ontogenesis." Journal of Anatomy and Histopathology 9, no. 3 (2020): 42–48. http://dx.doi.org/10.18499/2225-7357-2020-9-3-42-48.

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The aim of the study was to detect morphofunctional features of the retina of WAG/Rij rats during postnatal development from the 1st to the 360th day after birth.Material and methods. The study included retina of the inbred WAG/Rij rats (60 eyeballs from 30 rats totally) from the 1st to the 360th day of life. Standard histological studies were performed on paraffin sections stained with hematoxylin and eosin. Immunohistochemical method was used to determine the expression of acidic glial fibrillar protein GFAP in the rat retina. Mouse monoclonal antibodies (Santa Cruz Biotechnology) and a univ
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Fedosova, E. A., N. A. Loginova, and K. Yu Sarkisova. "The Effect of Maternal Methyl-Enriched Diet on the Number of Dopaminergic Neurons in the Ventral Tegmental Area in Adult Offspring of WAG/Rij Rats." Российский физиологический журнал им И М Сеченова 109, no. 7 (2023): 902–20. http://dx.doi.org/10.31857/s086981392307004x.

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WAG/Rij rats are genetic model of absence epilepsy with comorbid depression. Pathologic phenotype in WAG/Rij rats was shown to be associated with reduced dopamine (DA) tone within the mesolimbic DAergic brain system. Previously, it was found that maternal methyl-enriched diet (MED) in the perinatal period increases DA content in the mesolimbic DAergic brain system and reduces absence seizures and comorbid depression in adult offspring of WAG/Rij rats. Ventral tegmental area (VTA), containing DA cells bodies, is a main source of the mesolimbic DA synthesis. The aim of this study was to test the
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Celikyurt, Ipek Komsuoglu, Guner Ulak, Oguz Mutlu, Furuzan Yildiz Akar, Faruk Erden, and Sezer Sener Komsuoglu. "Lamotrigine effects sensorimotor gating in WAG/Rij rats." Journal of Neurosciences in Rural Practice 03, no. 02 (2012): 126–30. http://dx.doi.org/10.4103/0976-3147.98207.

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ABSTRACTIntroduction: Prepulse inhibition (PPI) is a measurable form of sensorimotor gating. Disruption of PPI reflects the impairment in the neural filtering process of mental functions that are related to the transformation of an external stimuli to a response. Impairment of PPI is reported in neuropsychiatric illnesses such as schizophrenia, Huntington’s disease, Parkinson’s diseases, Tourette syndrome, obsessive compulsive disorder, and temporal lobe epilepsy with psychosis. Absence epilepsy is the most common type of primary generalized epilepsy. Lamotrigine is an antiepileptic drug that
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Dissertations / Theses on the topic "Wag/Rij"

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Levin, April Robyn. "Early Seizure Blockade: Preventing Long-Term Epileptic Activity in Wag/Rij Rats." Yale University, 2008. http://ymtdl.med.yale.edu/theses/available/etd-08152007-130206/.

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The purpose of this study was to determine how early seizure blockade with ethosuximide (ESX) would influence ion channel expression and long-term spike-wave discharge (SWD) activity in epileptic WAG/Rij rats. The goal was to elucidate the question Do seizures beget seizures? in a genetically prone model and if so, to attempt to interrupt this cycle by early intervention. In our first experiment, we used immunocytochemistry to determine the effect of ESX on cortical expression of ion channels in treated and untreated WAG/Rij rats and age-matched Wistar controls. This experiment revealed that t
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Lucas, Susanne. "Anreicherungsverhalten von Kontrastmittel und Zytostatika enthaltenden Liposomen in der Leber von WAG-Rij-Ratten." [S.l.] : [s.n.], 2000. http://www.diss.fu-berlin.de/2001/190/index.html.

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Regenstein, Jens. "Therapiemonitoring im Langzeitversuch am CC-531-Adenokarzinom in der Leber von WAG-RIJ-Ratten mit Hilfe der Magnetresonanztomographie." [S.l.] : [s.n.], 2000. http://www.diss.fu-berlin.de/2001/191/index.html.

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PELLITTERI, Michele. "New evidences of inflammatory mediators in absence epilepsy." Doctoral thesis, Università degli Studi di Verona, 2010. http://hdl.handle.net/11562/342266.

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L'epilessia dell'assenza appartiene alle forme di epilessia di tipo generalizzato. Crisi di assenza sono caratterizzate a livello elettroencefalografico dall'insorgenza di onde-punta caratteristiche (SWDs) dovute ad una patologica attività sincronizzata del circuito talamo-corticale. Gli studi sono stati effettuati sul modello animale (Wag/Rij), ratti che dal sesto mese d'età presentano crisi di epilessia dell'assenza ricorrenti e spontanee. Ratti Wag/rij di quattro mesi d’età non ancora epilettici sono stati utilizzati come controllo. La più recente teoria volta a spiegare le cause dell'insor
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OUSAID-OUAZZANI, LATIFA. "Etude de l'expression de la somatostatine dans les cellules normales et tumorales d'un modele murin du cancer medullaire humain (rat wag/rij). Actions de la somatostatine sur la secretion et la proliferation des cellules c tumorales in vivo et in vitro." Paris 11, 1993. http://www.theses.fr/1993PA112403.

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Le cancer medullaire de la thyroide (cmt) provient de la tumorisation des cellules c. Elles secretent principalement la calcitonine (ct). La presence de somatostatine (ss) a ete signalee chez diverses especes aussi bien dans la thyroide normale que dans certains cas de cmt. Compte tenu des effets antisecretoire et antiproliferatif de ce peptide, nous avons examine d'eventuelles correlations entre sa secretion locale et l'evolution de la tumeur, dans un modele murin du cmt humain, le rat wag/rij. Nous avons d'abord localise, in vivo, la biosynthese de ss par les cellules c des tumeurs spontanee
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Lucas, Susanne [Verfasser]. "Anreicherungsverhalten von Kontrastmittel und Zytostatika enthaltenden Liposomen in der Leber von WAG-Rij-Ratten / vorgelegt von Susanne Lucas." 2000. http://d-nb.info/963665669/34.

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Regenstein, Jens [Verfasser]. "Therapiemonitoring im Langzeitversuch am CC-531-Adenokarzinom in der Leber von WAG-RIJ-Ratten mit Hilfe der Magnetresonanztomographie / vorgelegt von Jens Regenstein." 2000. http://d-nb.info/963779656/34.

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Karakizlis, Hristos [Verfasser]. "Effekt der Tiefenhirnstimulation des Nucleus subthalamicus auf die Anfallslänge und -frequenz im WAG-Rij- und im Kindling-Modell der Ratte / vorgelegt von Hristos Karakizlis." 2007. http://d-nb.info/985327847/34.

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Book chapters on the topic "Wag/Rij"

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Sitnikova, Evgenia, Kirill Smirnov, and Vladimir V. Raevsky. "Sensory Inflow from Whiskers Modulates Development of Absence Epilepsy in WAG/Rij Rats." In Advances in Cognitive Research, Artificial Intelligence and Neuroinformatics. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-71637-0_59.

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S., A. "Two Types of Epilepsy Models and Processes of Cognition: Pentylenetetrazole Kindling and Absence Epilepsy of WAG/Rij Rats Strain." In Underlying Mechanisms of Epilepsy. InTech, 2011. http://dx.doi.org/10.5772/21579.

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"Summary of Potential Models for Aging and Carcinogenesis Research Using Bn/Bi, W Ag/Rij, and (Wag × Bn)F1 Rats." In Pathology of Aging Rats, edited by Joe D. Burek. CRC Press, 2018. http://dx.doi.org/10.1201/9781351075435-13.

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Conference papers on the topic "Wag/Rij"

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Kenul, Abbasova, Darya Sydorenko, and Sergey Titov. "PTZ-KINDLING OF WAG/RIJ RATS." In XVII INTERNATIONAL INTERDISCIPLINARY CONGRESS NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY. LCC MAKS Press, 2021. http://dx.doi.org/10.29003/m2022.sudak.ns2021-17/44.

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Grubov, Vadim V., Evgenia Y. Sitnikova, Vladimir O. Nedaivozov, and Alexey A. Koronovskii. "Proepileptic patterns in EEG of WAG/Rij rats." In Saratov Fall Meeting 2017: Fifth International Symposium on Optics and Biophotonics: Laser Physics and Photonics XIX; Computational Biophysics and Analysis of Biomedical Data IV, edited by Vladimir L. Derbov and Dmitry E. Postnov. SPIE, 2018. http://dx.doi.org/10.1117/12.2315128.

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Smirnov, Kirill, Daria Tsvetaeva, and Evgenia Sitnikova. "NEONATAL WHISKER TRIMMING IN WAG/RIJ PUPS ENCOURAGES MATERNAL CARE." In XIV International interdisciplinary congress "Neuroscience for Medicine and Psychology". LLC MAKS Press, 2018. http://dx.doi.org/10.29003/m197.sudak.ns2018-14/426-427.

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De, Amiyangshu, Amit Konar, Amalesh Samanta, Souvik Biswas, and Piyali Basak. "Seizure prediction using low frequency EEG wavesfrom WAG/Rij rats." In 2017 2nd International Conference for Convergence in Technology (I2CT). IEEE, 2017. http://dx.doi.org/10.1109/i2ct.2017.8226129.

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Grubov, Vadim V., and Evgenia Sitnikova. "Detection of proepileptic activity patterns in EEG of WAG/Rij rats." In Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions, edited by Dmitry E. Postnov. SPIE, 2019. http://dx.doi.org/10.1117/12.2527707.

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Sayli, Omer. "Detection of spike-wave discharges in the EEG signals of WAG/Rij rats." In 2015 23th Signal Processing and Communications Applications Conference (SIU). IEEE, 2015. http://dx.doi.org/10.1109/siu.2015.7130161.

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Shishelova, Anna. "CRITICAL PERIODS IN A “MOTHER-INFANTS” SYSTEM IN WISTAR И WAG/RIJ RATS". У XIV International interdisciplinary congress "Neuroscience for Medicine and Psychology". LLC MAKS Press, 2018. http://dx.doi.org/10.29003/m203.sudak.ns2018-14/541-542.

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Grubov, Vadim V., Evgenia Y. Sitnikova, Alexey N. Pavlov, Marina V. Khramova, Alexey A. Koronovskii, and Alexander E. Hramov. "Age-dependent seizures of absence epilepsy and sleep spindles dynamics in WAG/Rij rats." In SPIE BiOS, edited by Valery V. Tuchin, Kirill V. Larin, Martin J. Leahy, and Ruikang K. Wang. SPIE, 2015. http://dx.doi.org/10.1117/12.2076734.

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Makarov, Vladimir V., Vladimir A. Maximenko, Gilles van Luijtelaar, Annika Lüttjohann, and Alexander E. Hramov. "Control of epileptic seizures in WAG/Rij rats by means of brain-computer interface." In Dynamics and Fluctuations in Biomedical Photonics XV, edited by Valery V. Tuchin, Kirill V. Larin, Martin J. Leahy, and Ruikang K. Wang. SPIE, 2018. http://dx.doi.org/10.1117/12.2291696.

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Gabova, Alexandra, Karine Sarkisova, Ekaterina Fedosova, Alla Shatskova, and Alexei Morozov. "AGE-RELATED CHANGES OF SPIKE-WAVE DISCHARGES IN WAG/RIJ RATS WITH GENETIC ABSANCE EPILEPSY." In XIV International interdisciplinary congress "Neuroscience for Medicine and Psychology". LLC MAKS Press, 2018. http://dx.doi.org/10.29003/m181.sudak.ns2018-14/147.

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