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Journal articles on the topic 'Wag/Rij'

Author: Grafiati

Published: 11 March 2023

Last updated: 31 July 2025

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1

Abbasova, К. R., S. М. Kuzhuget, and Е. Т. Tsyba. "Behavioural and electrophysiological features of WAG/Rij rats with different forms of genetic epilepsy." Rossijskij fiziologičeskij žurnal im. I.M. Sečenova 110, no. 10 (2024): 1733–51. https://doi.org/10.31857/s0869813924100116.

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WAG/Rij rats are widely used as a genetic model of absence epilepsy. Approximately 15–50% rats of the strain are susceptible to audiogenic seizures. WAG/Rij rats demonstrate depressive-like behavior. After preliminary sound provocation an increased level of anxiety was found in audiogenic susceptible WAG/Rij subgroup. Electrophysiological and behavioral studies suggest the involvement of the dopaminergic system in both absence and audiogenic epilepsy. An increased binding density to dopamine receptors was found in the dorsal striatum subregions in audiogenic prone rats compared to non-audiogen

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Габова, А. В., К. Ю. Саркисова, Е. А. Федосова, А. Б. Шацкова та А. А. Морозов. "ВОЗРАСТНЫЕ ИЗМЕНЕНИЯ ПИК-ВОЛНОВЫХ РАЗРЯДОВ У КРЫС ЛИНИИ WAG/Rij С ГЕНЕТИЧЕСКОЙ АБСАНСНОЙ ЭПИЛЕПСИЕЙ, "Российский физиологический журнал им. И.М. Сеченова"". Российский физиологический журнал им. И. М. Сеченова, № 10 (2018): 1176–89. http://dx.doi.org/10.7868/s0869813918100052.

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Крысы линии WAG/Rij являются моделью генетической абсансной эпилепсии, характеризующейся наличием пик-волновых разрядов (ПВР) на ЭЭГ. Известно, что первые ПВР у крыс линии WAG/Rij возникают в возрасте 2-3 месяцев, а в дальнейшем их число и длительность увеличиваются. Однако эволюция ПВР в процессе прогрессивного развития абсансной эпилепсии у крыс линии WAG/Rij остается неисследованной. Цель настоящей работы - выяснить возрастные изменения частотно-временной динамики, частотного спектра и морфологических характеристик ПВР у крыс линии WAG/Rij. Для достижения этой цели у одних и тех же крыс в в

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Zhuravlev, Maxim, Anastasiya Runnova, Kirill Smirnov, and Evgenia Sitnikova. "Spike-Wave Seizures, NREM Sleep and Micro-Arousals in WAG/Rij Rats with Genetic Predisposition to Absence Epilepsy: Developmental Aspects." Life 12, no. 4 (2022): 576. http://dx.doi.org/10.3390/life12040576.

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The current study was done in Wistar Albino Glaxo Rijswijk (WAG/Rij) rats, which are genetically prone to develop spontaneous spike-wave discharges (SWDs) and are widely used as a genetic model of absence epilepsy. Here, we examined functional links between sleep and spike-wave epilepsy in aging WAG/Rij rats using advanced techniques of EEG analysis. SWDs, periods of NREM sleep and micro-arousals were automatically detected in three-channel epidural EEG recorded in freely moving WAG/Rij rats consequently at the age 5, 7 and 9 months. We characterized the developmental profile of spike-wave epi

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Gabova, A. V., E. A. Fedosova, and K. Yu Sarkisova. "Spindles in WAG/Rij Rats with Absence Epilepsy and Comorbid Depression." Rossijskij fiziologičeskij žurnal im. I.M. Sečenova 110, no. 6 (2024): 1037–54. http://dx.doi.org/10.31857/s0869813924060115.

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WAG/Rij rats are a valid model of absence epilepsy and comorbid depression. We have previously shown that WAG/Rij rats have disturbances in the sleep-wake cycle and changes in the characteristics of sleep spindles. A negative correlation was also found between the number of spike-wave discharges (SWD) and the duration of rapid eye movement (REM) sleep. Clinical evidence suggests that the traditional antidepressants imipramine and fluoxetine are effective in suppressing symptoms of depression, but may have a negative impact on the sleep-wake cycle and comorbid epilepsy in patients. Our previous

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Ilbay, Gul, Aymen Balıkcı, Sibel Köktürk, et al. "Neonatal Tactile Stimulation Downregulates Dendritic Spines in Layer V Pyramidal Neurons of the WAG/Rij Rat Somatosensory Cortex." Neural Plasticity 2022 (April 12, 2022): 1–9. http://dx.doi.org/10.1155/2022/7251460.

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Objective. The aim of our study is to examine the effects of neonatal tactile stimulations on the brain structures that previously defined as the focus of epilepsy in the Wistar-Albino-Glaxo from Rijswijk (WAG/Rij) rat brain with genetic absence epilepsy. Methods. In the present research, morphology and density of dendritic spines were analyzed in layer V pyramidal neurons of the somatosensory cortex (SoCx) of WAG/Rij rats (nonstimulated control, tactile-stimulated, and maternal separated rats) and healthy Wistar (nonepileptic) rats. To achieve this, a Golgi-Cox method was used. Results. Dendr

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Musina, L. A., and A. I. Lebedeva. "Development of retinitis in WAG/Rij rats (Electron microscopic examination)." Modern technologies in ophtalmology 2, no. 4 (2024): 271–72. http://dx.doi.org/10.25276/2312-4911-2024-4-271-272.

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Актуальность. Разработка методов лечения любой патологии, в том числе и врожденных заболеваний сетчатки глаза, требует глубокого осмысления механизма их развития. Цель. Изучить ультраструктуру сетчатки глаза крыс линии WAG/Rij. Материал и методы. При помощи растрового электронного микроскопа JEM 1011 (Япония) исследована сетчатка глаз от 32 крыс линии WAG/Rij с рождения до их половозрелости. Результаты. В сетчатке крыс линии WAG/Rij ультраструктурные признаки дистрофических и деструктивных процессов начинают определяться к концу 3-й недели после рождения. Выявляется вакуолизация и деструкция н

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Dobryakova,*, Yulia, Vyacheslav Dubynin, and Gilles Luijtelaar. "The effect of haloperidol on maternal behavior in WAG/Rij rats and its consequences in the offspring." Acta Neurobiologiae Experimentalis 71, no. 3 (2011): 339–47. http://dx.doi.org/10.55782/ane-2011-1856.

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Haloperidol treatment during pre- and post-natal period affects maternal behavior and this may have long-term effects on the offspring. We examined whether early haloperidol administration to Wistar-Albino-Glaxo dams from Rijswijk (WAG/Rij) and in Wistar control rats would affect maternal care and as a consequence, seizure susceptibility and behavior in the WAG/Rij?s offspring at 3-4 months of age. Nursing dams of this well-validated genetic animal model of absence epilepsy and control dams were injected with haloperidol or saline at PPD 1 to 6. Maternal behavior was evaluated at PPD 7 to 9. H

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Musina, L. A., S. S. Baigil'din, and Z. R. Khismatullina. "Morphological study of the retina of WAG/Rij rats with pigmentary degeneration in postnatal ontogenesis." Journal of Anatomy and Histopathology 9, no. 3 (2020): 42–48. http://dx.doi.org/10.18499/2225-7357-2020-9-3-42-48.

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The aim of the study was to detect morphofunctional features of the retina of WAG/Rij rats during postnatal development from the 1st to the 360th day after birth.Material and methods. The study included retina of the inbred WAG/Rij rats (60 eyeballs from 30 rats totally) from the 1st to the 360th day of life. Standard histological studies were performed on paraffin sections stained with hematoxylin and eosin. Immunohistochemical method was used to determine the expression of acidic glial fibrillar protein GFAP in the rat retina. Mouse monoclonal antibodies (Santa Cruz Biotechnology) and a univ

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Fedosova, E. A., N. A. Loginova, and K. Yu Sarkisova. "The Effect of Maternal Methyl-Enriched Diet on the Number of Dopaminergic Neurons in the Ventral Tegmental Area in Adult Offspring of WAG/Rij Rats." Российский физиологический журнал им И М Сеченова 109, no. 7 (2023): 902–20. http://dx.doi.org/10.31857/s086981392307004x.

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WAG/Rij rats are genetic model of absence epilepsy with comorbid depression. Pathologic phenotype in WAG/Rij rats was shown to be associated with reduced dopamine (DA) tone within the mesolimbic DAergic brain system. Previously, it was found that maternal methyl-enriched diet (MED) in the perinatal period increases DA content in the mesolimbic DAergic brain system and reduces absence seizures and comorbid depression in adult offspring of WAG/Rij rats. Ventral tegmental area (VTA), containing DA cells bodies, is a main source of the mesolimbic DA synthesis. The aim of this study was to test the

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Celikyurt, Ipek Komsuoglu, Guner Ulak, Oguz Mutlu, Furuzan Yildiz Akar, Faruk Erden, and Sezer Sener Komsuoglu. "Lamotrigine effects sensorimotor gating in WAG/Rij rats." Journal of Neurosciences in Rural Practice 03, no. 02 (2012): 126–30. http://dx.doi.org/10.4103/0976-3147.98207.

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ABSTRACTIntroduction: Prepulse inhibition (PPI) is a measurable form of sensorimotor gating. Disruption of PPI reflects the impairment in the neural filtering process of mental functions that are related to the transformation of an external stimuli to a response. Impairment of PPI is reported in neuropsychiatric illnesses such as schizophrenia, Huntington’s disease, Parkinson’s diseases, Tourette syndrome, obsessive compulsive disorder, and temporal lobe epilepsy with psychosis. Absence epilepsy is the most common type of primary generalized epilepsy. Lamotrigine is an antiepileptic drug that

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Ilbay, Gul, Zeynep Ikbal Dogan, Aymen Balıkcı, Seyda Erdogan, and Akfer Karaoglan Kahilogulları. "Effects of Postnatal Caffeine Exposure on Absence Epilepsy and Comorbid Depression: Results of a Study in WAG/Rij Rats." Brain Sciences 12, no. 3 (2022): 361. http://dx.doi.org/10.3390/brainsci12030361.

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The present study aims to investigate effect of early caffeine exposure on epileptogenesis and occurrence of absence seizures and comorbid depression in adulthood. For this purpose, Wistar Albino Glaxo from Rijswijk (WAG/Rij) rats were enrolled in a control and two experimental groups on the 7th day after the delivery. The rats in experimental groups received either 10 or 20 mg/kg caffeine subcutaneously while animals in control group had subcutaneous injections of 0.9% saline. The injections started at postnatal day 7 (PND7) and were continued each day for 5 days. At 6–7 months of age, electr

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Gabova, A. V., and K. Yu Sarkisova. "Maternal Methyl-Enriched Diet Normalizes Characteristics of the Sleep–Wake Cycle and Sleep Spindles in Adult Offspring of WAG/Rij Rats with Genetic Absence Epilepsy." Российский физиологический журнал им И М Сеченова 109, no. 1 (2023): 75–93. http://dx.doi.org/10.31857/s086981392301003x.

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It has been previously shown that the perinatal maternal methyl-enriched diet (MED) reduces the number of spike-wave discharges (SWDs) and behavioral symptoms of depression in the adult offspring of WAG/Rij rats. Epilepsy and depression are usually accompanied by disturbances in the sleep-wake cycle. SWDs and sleep spindles are different manifestations of thalamocortical activity It is assumed that pathological alterations in the thalamocortical system that lead to SWD also change the sleep spindles. It is possible that the maternal MED has a positive effect not only on the SWD, but also on th

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De Miguel, M., J. M. Fernández-Santos, I. Trigo-Sánchez, et al. "The Ret proto-oncogene in the WAG/Rij rat strain: an animal model for inherited C-cell carcinoma?" Laboratory Animals 37, no. 3 (2003): 215–21. http://dx.doi.org/10.1258/002367703766453065.

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WAG/Rij rat strain has been suggested as an animal model for the study of inherited human medullary thyroid carcinoma (MTC), due to its high incidence of spontaneous C-cell thyroid tumours. Although the role of the Ret proto-oncogene mutations, as responsible for human MTC, is well established, nothing has been published concerning this putative animal model. Based upon the previously reported rat Ret sequence, exons 10, 11, 13, 14, 15, and 16, known to carry activating mutations in humans, have been analysed in the WAG/Rij rat by PCR, single strand conformational polymorphism (SSCP) and direc

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Citraro, Rita, Francesca Bosco, Gianfranco Di Gennaro, et al. "An In Vivo Electroencephalographic Analysis of the Effect of Riluzole against Limbic and Absence Seizure and Comparison with Glutamate Antagonists." Pharmaceutics 15, no. 7 (2023): 2006. http://dx.doi.org/10.3390/pharmaceutics15072006.

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Background: Riluzole (RLZ) has demonstrated neuroprotective effects in several neurological disorders. These neuroprotective effects seem to be mainly due to its ability to inhibit the excitatory glutamatergic neurotransmission, acting on different targets located both at the presynaptic and postsynaptic levels. Methods: In the present study, we evaluated the effects of Riluzole (RLZ) against limbic seizures, induced by AMPA, kainate, and NMDA receptor agonists in Sprague–Dawley rats, and in a well-validated genetic model of absence epilepsy, the WAG/Rij rat. Furthermore, in this latter model,

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Rauch, Enikő, Csilla Ari, and Zsolt Kovács. "Dose-Dependent Beneficial Effect of Ketone Supplement-Evoked Ketosis on Anxiety Level in Female WAG/Rij Rats: Sometimes Less Is More." Nutrients 15, no. 20 (2023): 4412. http://dx.doi.org/10.3390/nu15204412.

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While one-third of the population can be affected by anxiety disorders during their lifetime, our knowledge of the pathophysiology of these disorders is far from complete. Previously, it has been demonstrated in male animals that exogenous ketone supplement-evoked ketosis can decrease anxiety levels in preclinical rodent models, such as Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. Thus, in this study, we investigated whether intragastric gavage of the exogenous ketone supplement KEMCT (mix of 1,3-butanediol-acetoacetate diester/ketone ester/KE and medium-chain triglyceride/MCT oil in 1:1 ratio

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Poolos, Nicholas P. "H-Channel Dysfunction in Generalized Epilepsy: It Takes Two." Epilepsy Currents 6, no. 3 (2006): 88–90. http://dx.doi.org/10.1111/j.1535-7511.2006.00107.x.

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Impaired Regulation of Thalamic Pacemaker Channels Through an Imbalance of Subunit Expression in Absence Epilepsy Budde T, Caputi L, Kanyshkova T, Staak R, Abrahamczik C, Munsch T, Pape HC J Neurosci 2005;25(43):9871–9882 The role of hyperpolarization-activated, cyclic nucleotide-modulated (HCN) channel isoforms and hyperpolarization-activated cation current ( Ih) for seizure-related burst firing in thalamocortical (TC) neurons was investigated in a rat genetic model of absence epilepsy [Wistar Albino Glaxo rats, bred in Rijswijk (WAG/Rij)]. Burst discharges in TC neurons locked to seizure act

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Sitnikova, Evgenia, Alexander E. Hramov, Vadim Grubov, and Alexey A. Koronovsky. "Age-Dependent Increase of Absence Seizures and Intrinsic Frequency Dynamics of Sleep Spindles in Rats." Neuroscience Journal 2014 (June 23, 2014): 1–6. http://dx.doi.org/10.1155/2014/370764.

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The risk of neurological diseases increases with age. In WAG/Rij rat model of absence epilepsy, the incidence of epileptic spike-wave discharges is known to be elevated with age. Considering close relationship between epileptic spike-wave discharges and physiologic sleep spindles, it was assumed that age-dependent increase of epileptic activity may affect time-frequency characteristics of sleep spindles. In order to examine this hypothesis, electroencephalograms (EEG) were recorded in WAG/Rij rats successively at the ages 5, 7, and 9 months. Spike-wave discharges and sleep spindles were detect

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ÇELİK, Zülfinaz Betül, Emre Soner TİRYAKİ, Elif TÜRKDÖNMEZ, M. Nusret ÇİÇEKLİ, Ahmet ALTUN, and Caner GÜNAYDIN. "Parallel changes in the promoter methylation of voltage-gated T-type calcium channel alpha 1 subunit G and histone deacetylase activity in the WAG/Rij model of absence epilepsy." Journal of Health Sciences and Medicine 6, no. 1 (2023): 92–98. http://dx.doi.org/10.32322/jhsm.1207399.

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Objective: In the last two decades, research on epigenetic mechanisms has expanded dramatically. Recent studies demonstrated that epigenetic mechanisms regulate epilepsy and epileptogenic pathologies. In this study, we aimed to investigate changes in the promoter methylation status of the voltage-gated T-type calcium channel alpha 1 subunit G (CACNA1G) gene and total histone deacetylase activity in Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats which is one of the commonly used genetic absence rat models of epilepsy in the three different age groups (3, 6, and 9 months old) on both sexes. 

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Sarkisova, Karine Yu, Ekaterina A. Fedosova, Alla B. Shatskova, Margarita M. Rudenok, Vera A. Stanishevskaya, and Petr A. Slominsky. "Maternal Methyl-Enriched Diet Increases DNMT1, HCN1, and TH Gene Expression and Suppresses Absence Seizures and Comorbid Depression in Offspring of WAG/Rij Rats." Diagnostics 13, no. 3 (2023): 398. http://dx.doi.org/10.3390/diagnostics13030398.

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The reduced expression of the HCN1 ion channel in the somatosensory cortex (SSC) and mesolimbic dopamine deficiency are thought to be associated with the genesis of spike-wave discharges (SWDs) and comorbid depression in the WAG/Rij rat model of absence epilepsy. This study aimed to investigate whether the maternal methyl-enriched diet (MED), which affects DNA methylation, can alter DNMT1, HCN1, and TH gene expression and modify absence seizures and comorbid depression in WAG/Rij offspring. WAG/Rij mothers were fed MED (choline, betaine, folic acid, vitamin B12, L-methionine, zinc) or a contro

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Sitnikova, Evgenia, Sofia Kulikova, Lidia Birioukova, and Vladimir Raevsky. "Cellular neuropathology of absence epilepsy in the neocortex: a population of glial cells rather than neurons is impaired in genetic rat model." Acta Neurobiologiae Experimentalis 71, no. 2 (2011): 263–68. http://dx.doi.org/10.55782/ane-2011-1846.

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It is well accepted that absence epilepsy is not accompanied by structural brain abnormalities. In the present report, we challenged this view based on microscopic analysis of neocortex in a genetic model of absence epilepsy, WAG/Rij rats. Density of neurons and glial cells was measured in the motor, somatosensory and cingular cortical areas in epileptic WAG/Rij rats and in non-epileptic control ACI rats. More extensive and significant differences between two strains were found in a population of glial cells and less significant - in neurons. In contract to ACI rats, WAG/Rij rats showed (1) a

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Sitnikova, Evgenia. "Behavioral and Cognitive Comorbidities in Genetic Rat Models of Absence Epilepsy (Focusing on GAERS and WAG/Rij Rats)." Biomedicines 12, no. 1 (2024): 122. http://dx.doi.org/10.3390/biomedicines12010122.

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Absence epilepsy is a non-convulsive type of epilepsy characterized by the sudden loss of awareness. It is associated with thalamo-cortical impairment, which may cause neuropsychiatric and neurocognitive problems. Rats with spontaneous absence-like seizures are widely used as in vivo genetic models for absence epilepsy; they display behavioral and cognitive problems similar to epilepsy in humans, such as genetic absence epilepsy rats from Strasbourg (GAERS) and Wistar Albino rats from Rijswijk (WAG/Rij). Depression- and anxiety-like behaviors were apparent in GAERS, but no anxiety and depressi

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Sitnikova, E. Yu, K. S. Smirnov, V. V. Grubov, and A. E. Hramov. "Diagnostic principles of immature epileptic (proepileptic) EEG activity in rats with genetic predisposition to absence epilepsy." Information and Control Systems, no. 1 (February 19, 2019): 89–97. http://dx.doi.org/10.31799/1684-8853-2019-1-89-97.

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Introduction:Absence epilepsy is a specific neurological disorder characterized by brief episodes of loss of consciousness (absence) accompanied by high-amplitude “spike-wave” discharges in the electroencephalogram (EEG). WAG/Rij rats with a genetic predisposition to absence epilepsy are used as a reliable model of this disease. This model is beneficial for investigating basic mechanisms of absence epilepsy, including the development of spike-wave seizures.Purpose:Establishing diagnostic principles for immature forms of spikewave activity in EEG (so-called proepileptic activity) of WAG/Rij rat

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Alexandrov, Pavel, Maria Pupikina, Zabava Adaeva, and Evgenia Sitnikova. "The Difference between Male and Female Rats in Terms of Freezing and Aversive Ultrasonic Vocalization in an Active Avoidance Test." Physiologia 3, no. 3 (2023): 406–20. http://dx.doi.org/10.3390/physiologia3030028.

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We examined sex differences in behavioral responses to fear-related learning through ultrasonic vocalization. Adult male and female rats of two inbred rat strains (WAG/Rij rats with genetic predisposition absence epilepsy, n = 25; and the minor substrain NEW with non-epileptic phenotype, n = 32) were examined in the two-way active avoidance task (50 trials). Three behavioral responses were defined: successful learning, unsuccessful learning, and freezing (motionless behavior). We found that males were more likely to experience freezing (40%) than females (3.7%). Females performed significantly

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Tolmacheva, Elena A., Serguei A. Chepurnov, Nina E. Chepurnova, Yakov A. Kochetkov, and Gilles van Luijtelaar. "Absence seizures during pregnancy in WAG/Rij rats." Physiology & Behavior 81, no. 4 (2004): 623–27. http://dx.doi.org/10.1016/j.physbeh.2004.02.028.

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Dobryakova, Yulia, Vyacheslav Dubynin, and Gilles Luijtelaar. "Maternal behavior in a genetic animal model of absence epilepsy." Acta Neurobiologiae Experimentalis 68, no. 4 (2008): 502–8. http://dx.doi.org/10.55782/ane-2008-1716.

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In this study we quantified maternal behavior in genetic epileptic rats with deficiencies in the DA system known to be involved in maternal behavior in order to assess whether these rats have disturbances in maternal care. Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats, a genetic model for generalized absence epilepsy and Wistar rats were compared. Maternal behavior parameters and activity scores were quantified from post-natal day (PND) 4-6 in an open field in the presence of pups. WAG/Rij rats had less approaches to the pups and higher latencies of approaching them compared to Wistar, while loc

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Fedosova, E. A., A. B. Shatskova, and K. Yu Sarkisova. "Maternal Methyl-Enriched Diet Improves Episodic Memory and Does Not Affect the Conditioned Fear Memory in Offspring of WAG/RIJ Rats." Rossijskij fiziologičeskij žurnal im. I.M. Sečenova 110, no. 5 (2024): 783–98. http://dx.doi.org/10.31857/s0869813924050097.

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The purpose of this study is to find out what effect the maternal methyl-enriched diet (MED) in the perinatal period exerts on cognitive functions in adult offspring of WAG/Rij rats, a genetic model of absence epilepsy with comorbid depression. Cognitive functions (learning and memory) were evaluated in tests of a novel object recognition (NOR) and a conditioning of fear memory (fear conditioning). The experiments were carry out on 6-months old male WAG/Rij rats. The mothers of the experimental group fed MED, and the mothers of the control group fed the control diet. The NOR test was used to a

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Луїджтелаар, Дж. ван, та Дж. ван Ойджен. "СУЧАСНІ ПРИНЦИПИ ТА ТЕХНІЧНЕ ЗАБЕЗПЕЧЕННЯ ДОСЛІДЖЕНЬ НА МОДЕЛІ ГЕНЕТИЧНОЇ ФОРМИ АБСАНСНОЇ ЕПІЛЕПСІЇ". Medical Informatics and Engineering, № 1 (22 червня 2020): 45–65. http://dx.doi.org/10.11603/mie.1996-1960.2020.1.11129.

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Визначення валідної експериментальної моделі абсансної епілепсії є важливим як по відношенню до вивчення механізмів заховарювання, так і обґрунтування методів його лікування. Генетичні моделі WAG/Rij та GAERS створено як моделі генералізованої генетично детермінованої форми епілепсії, що відображають особливості абсансної епілепсії дитячого віку та на сьогодні являються провідними щодо визначення причин походження абсансної епілепсії. В огляді літератури наведено узагальнення 40-річного досвіду роботи з питань вивчення експериментальної абсансної епілепсії з метою визначення найбільш оптимальн

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Knowles, Juliet K., Haojun Xu, Caroline Soane, et al. "Maladaptive myelination promotes generalized epilepsy progression." Nature Neuroscience 25, no. 5 (2022): 596–606. http://dx.doi.org/10.1038/s41593-022-01052-2.

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AbstractActivity-dependent myelination can fine-tune neural network dynamics. Conversely, aberrant neuronal activity, as occurs in disorders of recurrent seizures (epilepsy), could promote maladaptive myelination, contributing to pathogenesis. In this study, we tested the hypothesis that activity-dependent myelination resulting from absence seizures, which manifest as frequent behavioral arrests with generalized electroencephalography (EEG) spike-wave discharges, promote thalamocortical network hypersynchrony and contribute to epilepsy progression. We found increased oligodendrogenesis and mye

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Rauch, Enikő, Csilla Ari, Dominic P. D’Agostino, and Zsolt Kovács. "Exogenous Ketone Supplement Administration Abrogated Isoflurane-Anesthesia-Induced Increase in Blood Glucose Level in Female WAG/Rij Rats." Nutrients 16, no. 10 (2024): 1477. http://dx.doi.org/10.3390/nu16101477.

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It has been demonstrated that isoflurane-induced anesthesia can increase the blood glucose level, leading to hyperglycemia and several adverse effects. The administration of a mix of ketone diester (KE) and medium-chain triglyceride (MCT) oil, named KEMCT, abolished the isoflurane-anesthesia-induced increase in blood glucose level and prolonged the recovery time from isoflurane anesthesia in a male preclinical rodent model, Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. While most preclinical studies use exclusively male animals, our previous study on blood glucose changes in response to KEMCT a

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Rauch, Enikő, Csilla Ari, Dominic P. D’Agostino, and Zsolt Kovács. "Exogenous Ketone Supplementation Enhances the Anti-Epileptic Effect of Levetiracetam in Wistar Albino Glaxo/Rijswijk Rats." Nutrients 17, no. 10 (2025): 1721. https://doi.org/10.3390/nu17101721.

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Background: It has been demonstrated that levetiracetam can decrease absence epileptic activity in both human patients and different types of animal models of absence epilepsy, such as the genetically absence epileptic Wistar Albino Glaxo/Rijswijk (WAG/Rij) rat. It was also suggested previously that exogenous ketone supplements (EKSs)-evoked ketosis not only decreases the number of spike-wave discharges (SWDs) but also enhances the anti-absence epileptic effect of pyrimidine nucleoside uridine in WAG/Rij rats. These findings suggest that EKSs may enhance the efficacy of clinically used anti-ep

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Yildiz, Ozlem Kayim, Caglar Yildiz, Nedim Durmus, Sefa Gulturk, Selim Benek, and Ali Cetin. "Ovariectomy enhances spike-wave discharges in WAG/Rij rats." Neurology, Psychiatry and Brain Research 17, no. 3 (2011): 67–70. http://dx.doi.org/10.1016/j.npbr.2011.06.005.

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Саркисова, К. Ю., М. А. Куликов, В. С. Кудрин та ін. "Нейрохимические механизмы депрессивноподобного поведения у крыс линии WAG/RIJ". Журнал высшей нервной деятельности им. И. В. Павлова 63, № 3 (2013): 303–15. http://dx.doi.org/10.7868/s0044467713030106.

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Malyshev, A. V., A. M. Zakharov, K. Yu Sarkisova, and V. A. Dubynin. "Reversal Learning in WAG/Rij Rats with Depression-Like Behavior." Neuroscience and Behavioral Physiology 44, no. 1 (2013): 36–43. http://dx.doi.org/10.1007/s11055-013-9869-y.

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Renier, W. O., and A. M. L. Coenen. "Human absence epilepsy: The WAG/Rij rat as a model." Neuroscience Research Communications 26, no. 3 (2000): 181–91. http://dx.doi.org/10.1002/1520-6769(200005/06)26:3<181::aid-nrc6>3.0.co;2-f.

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Nersesyan, Hrachya, Fahmeed Hyder, Douglas L. Rothman, and Hal Blumenfeld. "Dynamic fMRI and EEG Recordings during Spike-Wave Seizures and Generalized Tonic-Clonic Seizures in WAG/Rij Rats." Journal of Cerebral Blood Flow & Metabolism 24, no. 6 (2004): 589–99. http://dx.doi.org/10.1097/01.wcb.0000117688.98763.23.

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Generalized epileptic seizures produce widespread physiological changes in the brain. Recent studies suggest that “generalized” seizures may not involve the whole brain homogeneously. For example, electrophysiological recordings in WAG/Rij rats, an established model of human absence seizures, have shown that spike-and-wave discharges are most intense in the perioral somatosensory cortex and thalamus, but spare the occipital cortex. Is this heterogeneous increased neuronal activity matched by changes in local cerebral blood flow sufficient to meet or exceed cerebral oxygen consumption? To inves

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Tsyba, Evgeniya T., Inna S. Midzyanovskaya, Lidia M. Birioukova, Leena M. Tuomisto, Gilles van Luijtelaar, and Kenul R. Abbasova. "Striatal Patchwork of D1-like and D2-like Receptors Binding Densities in Rats with Genetic Audiogenic and Absence Epilepsies." Diagnostics 13, no. 4 (2023): 587. http://dx.doi.org/10.3390/diagnostics13040587.

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Binding densities to dopamine D1-like and D2-like receptors (D1DR and D2DR) were studied in brain regions of animals with genetic generalized audiogenic (AGS) and/or absence (AbS) epilepsy (KM, WAG/Rij-AGS, and WAG/Rij rats, respectively) as compared to non-epileptic Wistar (WS) rats. Convulsive epilepsy (AGS) exerted a major effect on the striatal subregional binding densities for D1DR and D2DR. An increased binding density to D1DR was found in the dorsal striatal subregions of AGS-prone rats. Similar changes were seen for D2DR in the central and dorsal striatal territories. Subregions of the

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Sarkisova, Karine Yu, Alexandra V. Gabova, Ekaterina A. Fedosova, Alla B. Shatskova, Victor B. Narkevich, and Vladimir S. Kudrin. "Antidepressant and Anxiolytic Effects of L-Methionine in the WAG/Rij Rat Model of Depression Comorbid with Absence Epilepsy." International Journal of Molecular Sciences 24, no. 15 (2023): 12425. http://dx.doi.org/10.3390/ijms241512425.

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Depression is a severe and widespread psychiatric disease that often accompanies epilepsy. Antidepressant treatment of depression comorbid with epilepsy is a major concern due to the risk of seizure aggravation. SAMe, a universal methyl donor for DNA methylation and the synthesis of brain monoamines, is known to have high antidepressant activity. This study aimed to find out whether L-methionine (L-MET), a precursor of SAMe, can have antidepressant and/or anxiolytic effects in the WAG/Rij rat model of depression comorbid with absence epilepsy. The results indicate that L-MET reduces the level

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Саркисова, К. Ю., А. В. Габова, М. А. Куликов, Е. А. Федосова, А. Б. Шацкова та А. А. Морозов. "ВОСПИТАНИЕ ПРИЕМНОЙ МАТЕРЬЮ Wistar С ВЫСОКИМ УРОВНЕМ ПРОЯВЛЕНИЯ МАТЕРИНСКОЙ ЗАБОТЫ ПРЕПЯТСТВУЕТ РАЗВИТИЮ НАСЛЕДСТВЕННОЙ АБСАНСНОЙ ЭПИЛЕПСИИ И КОМОРБИДНОЙ ДЕПРЕССИИ У КРЫС ЛИНИИ WAG/Rij, "Доклады Академии наук"". Доклады Академии Наук, № 2 (2017): 246–49. http://dx.doi.org/10.7868/s086956521708028x.

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Впервые показано, что воспитание приемной матерью Wistar с высоким уровнем проявления материнской заботы (МЗ) подавляет выраженность наследственной абсансной эпилепсии (АЭ) и коморбидной депрессии: уменьшает число, длительность, индекс пик-волновых разрядов (ПВР) и время иммобилизации в тесте вынужденного плавания, а также существенно влияет на морфологию и частотно-временную динамику ПВР у крыс линии WAG/Rij. Предполагается, что усиление МЗ в раннем возрасте может быть использовано для предотвращения эпилептогенеза и коморбидной депрессии у людей с генетической предрасположенностью к АЭ.

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Brunner, Brigitta, Enikő Rauch, Csilla Ari, Dominic P. D’Agostino, and Zsolt Kovács. "Enhancement of Ketone Supplements-Evoked Effect on Absence Epileptic Activity by Co-Administration of Uridine in Wistar Albino Glaxo Rijswijk Rats." Nutrients 13, no. 1 (2021): 234. http://dx.doi.org/10.3390/nu13010234.

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Both uridine and exogenous ketone supplements decreased the number of spike-wave discharges (SWDs) in a rat model of human absence epilepsy Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. It has been suggested that alleviating influence of both uridine and ketone supplements on absence epileptic activity may be modulated by A1 type adenosine receptors (A1Rs). The first aim was to determine whether intraperitoneal (i.p.) administration of a specific A1R antagonist 1,3-dipropyl-8-cyclopentylxanthine (DPCPX; 0.2 mg/kg) and a selective adenosine A2A receptor antagonist (7-(2-phenylethyl)-5-amino-2-(2

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Luijtelaar, G., and M. Zobeiri. "Progress and Outlooks in a Genetic Absence Epilepsy Model (WAG/Rij)." Current Medicinal Chemistry 21, no. 6 (2014): 704–21. http://dx.doi.org/10.2174/0929867320666131119152913.

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LaVail, M. M., D. S. Papermaster, C. D. B. Bridges, L. M. Rapp, F. Gonzalez-Fernandez, and Joe G. Hollyfield. "Absence of an inherited retinal degeneration in the WAG/Rij rat." Experimental Eye Research 44, no. 3 (1987): 465–69. http://dx.doi.org/10.1016/s0014-4835(87)80180-x.

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Midzyanovskaya, Inna S., Galina D. Kuznetsova, Liudmila V. Vinogradova, Alla B. Shatskova, Anton M. L. Coenen, and Gilles van Luijtelaar. "Mixed forms of epilepsy in a subpopulation of WAG/Rij rats." Epilepsy & Behavior 5, no. 5 (2004): 655–61. http://dx.doi.org/10.1016/j.yebeh.2004.06.021.

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Aker, Rezzan Gulhan, Hasan Raci Yananli, Ayten Azizova Gurbanova, et al. "Amygdala Kindling in the WAG/Rij Rat Model of Absence Epilepsy." Epilepsia 47, no. 1 (2006): 33–40. http://dx.doi.org/10.1111/j.1528-1167.2006.00367.x.

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Przewłocka, B., W. Lasoń, H. Machelska, G. van Luijtelaar, A. Coenen, and R. Przewłocki. "Kappa opioid receptor agonists suppress absence seizures in WAG/Rij rats." Neuroscience Letters 186, no. 2-3 (1995): 131–34. http://dx.doi.org/10.1016/0304-3940(95)11303-e.

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Midzyanovskaya, I., M. Kopilov, E. Fedotova, G. Kuznetsova, and L. Tuomisto. "Dual effect of pyrilamine on absence seizures in WAG/Rij rats." Inflammation Research 54, S1 (2005): S40—S41. http://dx.doi.org/10.1007/s00011-004-0418-6.

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Helderman, Roxan F. C. P. A., Mauricio Tobón Restrepo, Hans M. Rodermond, et al. "Non-Invasive Imaging and Scoring of Peritoneal Metastases in Small Preclinical Animal Models Using Ultrasound: A Preliminary Trial." Biomedicines 10, no. 7 (2022): 1610. http://dx.doi.org/10.3390/biomedicines10071610.

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Background: The peritoneum is a common site for the formation of metastases originating from several gastrointestinal and gynecological malignancies. A representative preclinical model to thoroughly explore the pathophysiological mechanisms and to study new treatment strategies is important. A major challenge for such models is defining and quantifying the (total) tumor burden in the peritoneal cavity prior to treatment, since it is preferable to use non-invasive methods. We evaluated ultrasound as a simple and easy-to-handle imaging method for this purpose. Methods: Peritoneal metastases were

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Birioukova, Lidia M., Gilles van Luijtelaar, and Inna S. Midzyanovskaya. "D1-Like and D2-Like Dopamine Receptors in the Rat Prefrontal Cortex: Impacts of Genetic Generalized Epilepsies and Social Behavioral Deficits." Receptors 3, no. 1 (2024): 36–57. http://dx.doi.org/10.3390/receptors3010004.

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The involvement of the prefrontal cortical dopaminergic system in the psychopathology of epilepsies and comorbid conditions such as autism spectrum disorder (ASD) still needs to be explored. We used autoradiography to study the D1-like (D1DR) and D2-like (D2DR) receptor binding density in the prefrontal cortex of normal Wistar rats and Wistar-derived strains with generalized convulsive and/or non-convulsive epilepsy. WAG/Rij rats served as a model for non-convulsive absence epilepsy, WAG/Rij-AGS as a model of mixed convulsive/non-convulsive form, and KM strain was a model for convulsive epilep

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DEMİRTAŞ ŞAHİN, Tuğçe, Tijen UTKAN, Ayşe KARSON, Yusufhan YAZIR, and Erdal KARAOZ. "Genetik absans epilepsili WAG/Rij sıçanlarda kardiyovasküler değişiklikler: Kronik etosüksimid tedavisinin etkileri." Cukurova Medical Journal 45, no. 3 (2020): 769–77. http://dx.doi.org/10.17826/cumj.724491.

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Mishra, Asht M., Xiaoxiao Bai, Joshua E. Motelow, et al. "Increased resting functional connectivity in spike-wave epilepsy in WAG/Rij rats." Epilepsia 54, no. 7 (2013): 1214–22. http://dx.doi.org/10.1111/epi.12227.

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Bouwman, Brigitte M., and Clementina M. van Rijn. "Effects of levetiracetam on spike and wave discharges in WAG/Rij rats." Seizure 13, no. 8 (2004): 591–94. http://dx.doi.org/10.1016/j.seizure.2004.02.001.

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