Journal articles: 'Waltham (Mass.)'

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Salamone, Loran M., Thomas Fuerst, Marjolein Visser, Marialice Kern, Thomas Lang, Maurice Dockrell, Jane A. Cauley, Michael Nevitt, Francis Tylavsky, and Tim G. Lohman. "Measurement of fat mass using DEXA: a validation study in elderly adults." Journal of Applied Physiology 89, no. 1 (July 1, 2000): 345–52. http://dx.doi.org/10.1152/jappl.2000.89.1.345.

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The accuracy of total body fat mass and leg fat mass measurements by fan-beam dual-energy X-ray absorptiometry (DEXA) was assessed in 60 healthy elderly subjects (aged 70–79 yr). Total fat and leg fat mass at four leg regions (total leg, thigh, midthigh, and calf) were measured with the QDR 4500A (Hologic, Waltham, MA). The four-compartment model and multislice computed tomography scans were selected as criterion methods for total fat and leg fat mass, respectively. Total fat mass from DEXA was positively associated with fat mass from the four-compartment model with a standard error of the estimate ranging from 1.4 to 1.6 kg. DEXA fan-beam tended to overestimate fat mass for total leg and total thigh fat mass, whereas only marginal differences in fat mass measurements at the midthigh and calf were demonstrated (≤0.08 kg, P< 0.0005). Although there were significant differences between DEXA fan beam and the criterion methods, these differences were of small magnitude, suggesting that DEXA is an accurate method for measurement of fat mass for the elderly.

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Barrio-Parra, Fernando, Miguel Izquierdo-Díaz, Luis Jesús Fernández-Gutiérrez del Álamo, Bárbara Biosca, and Eduardo De Miguel. "Modelling the Transference of Trace Elements between Environmental Compartments in Abandoned Mining Areas." International Journal of Environmental Research and Public Health 17, no. 14 (July 15, 2020): 5117. http://dx.doi.org/10.3390/ijerph17145117.

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An openly accessible cellular automaton has been developed to predict the preferential migration pathways of contaminants by surface runoff in abandoned mining areas. The site where the validation of the results of the Contaminant Mass Transfer Cellular Automaton (CMTCA) has been carried out is situated on the steep flank of a valley in the Spanish northwestern region of Asturias, at the foot of which there is a village with 400 inhabitants, bordered by a stream that flows into a larger river just outside the village. Soil samples were collected from the steep valley flank where the mine adits and spoil heaps are situated, at the foot of the valley, and in the village, including private orchards. Water and sediment samples were also collected from both surface water courses. The concentration of 12 elements, including those associated with the Cu-Co-Ni ore, were analyzed by ICP-OES (Perkin Elmer Optima 3300DV, Waltham, MA, USA) and ICP-MS (Perkin Elmer NexION 2000, Waltham, MA, USA). The spatial representation of the model’s results revealed that those areas most likely to be crossed by soil material coming from source zones according to the CMTCA exhibited higher pollution indexes than the rest. The model also predicted where the probabilities of soil mass transfer into the stream were highest. The accuracy of this prediction was corroborated by the results of trace element concentrations in stream sediments, which, for elements associated with the mineral paragenesis (i.e., Cu, Co, Ni, and also As), increased between five- and nine-fold downstream from the predicted main transfer point. Lastly, the river into which the stream discharges is also affected by the mobilization of mined materials, as evidenced by an increase of up to 700% (in the case of Cu), between dissolved concentrations of those same elements upstream and downstream of the confluence of the river and the stream.

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WEILL, Georges. "La conférence internationale sur «Les juifs dans la France contemporaine» (Université Brandeis, Waltham (Mass.), 16-19 avril 1983)." Revue des Études Juives 144, no. 1 (January 1, 1985): 293–96. http://dx.doi.org/10.2143/rej.144.1.2012997.

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Ma, Zhe, Xuexiao Cao, Xiao Guo, Meng Wang, Xiaoliang Ren, Ranran Dong, Rui Shao, and Yan Zhu. "Establishment and Validation of an In Vitro Screening Method for Traditional Chinese Medicine-Induced Nephrotoxicity." Evidence-Based Complementary and Alternative Medicine 2018 (June 28, 2018): 1–15. http://dx.doi.org/10.1155/2018/2461915.

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Renal injury is among the adverse drug reactions (ADRs) caused by herbal medicine products (HMPs). Traditional Chinese medicines (TCMs) have been practiced for over 2000 years in China and East Asia, and herbs are currently used worldwide for the treatment and prevention of chronic and acute disease. Operetta high content analysis (HCA, PerkinElmer, Waltham, MA, USA), which is an in vitro, sensitive, reproducible, multiparametric screening method, was used to evaluate the cytotoxicity of HMPs in cultures of HEK293 human embryo kidney cells. Cytotoxic results were validated by an animal-based subacute toxicity assay. The renal safety of 18 active pharmaceutical agents from 13 TCM herbs with known nephrotoxic potential was evaluated in HEK293 human embryonic kidney cells. A panel of five parameters, cell viability, nuclear area, nuclear roundness, mitochondrial mass, and mitochondrial membrane potential, was utilized to evaluate drug-induced renal mitochondrial and nuclear injury. HCA can be a useful tool for preclinical screening and postclinical evaluation of HMPs. The nephrotoxicity of diosbulbin B and other HMPs was evident at a concentration as low as 0.01 μM.

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Amerinatanzi, Amirhesam, Reza Mehrabi, Hamdy Ibrahim, Amir Dehghan, Narges Shayesteh Moghaddam, and Mohammad Elahinia. "Predicting the Biodegradation of Magnesium Alloy Implants: Modeling, Parameter Identification, and Validation." Bioengineering 5, no. 4 (November 29, 2018): 105. http://dx.doi.org/10.3390/bioengineering5040105.

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Magnesium (Mg) and its alloys can degrade gradually up to complete dissolution in the physiological environment. This property makes these biomaterials appealing for different biomedical applications, such as bone implants. In order to qualify Mg and its alloys for bone implant applications, there is a need to precisely model their degradation (corrosion) behavior in the physiological environment. Therefore, the primary objective develop a model that can be used to predict the corrosion behavior of Mg-based alloys in vitro, while capturing the effect of pitting corrosion. To this end, a customized FORTRAN user material subroutine (or VUMAT) that is compatible with the finite element (FE) solver Abaqus/Explicit (Dassault Systèmes, Waltham, MA, USA) was developed. Using the developed subroutine, a continuum damage mechanism (CDM) FE model was developed to phenomenologically estimate the corrosion rate of a biocompatible Mg–Zn–Ca alloy. In addition, the mass loss immersion test was conducted to measure mass loss over time by submerging Mg–Zn–Ca coupons in a glass reactor filled with simulated body fluid (SBF) solution at pH 7.4 and 37 °C. Then, response surface methodology (RSM) was applied to calibrate the corrosion FE model parameters (i.e., Gamma (γ), Psi (ψ), Beta (β), and kinetic parameter (Ku)). The optimum values for γ, ψ, β and Ku were found to be 2.74898, 2.60477, 5.1, and 0.1005, respectively. Finally, given the good fit between FE predictions and experimental data, it was concluded that the numerical framework precisely captures the effect of corrosion on the mass loss over time.

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Qin, Zeshi, and Juan Shi. "Feasibility of Species Origin Traceability by Hydrogen Stable Isotopes: Sample Case of Lymantria dispar L. (Lepidoptera: Erebidae)." Forests 11, no. 11 (November 17, 2020): 1209. http://dx.doi.org/10.3390/f11111209.

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Lymantria dispar L. (Lepidoptera: Erebidae) is an international quarantine pest with many hosts, widely distributed in Asia, Europe, and America. L. dispar is distributed mainly in the Eastern Monsoon Region of China. Currently, the most effective means of prevention and control of this pest are timely monitoring and early warning. However, their implementation is usually hampered by the lack of feasible methods and tools for fast tracking and traceability. Stable isotope technology can be used for material traceability, but in China, it is rarely employed for insect traceability. Therefore, using L. dispar as an example, we conducted a case study to explore the feasibility of using hydrogen stable isotopes for pest-source traceability. The grid data of hydrogen stable isotopes of global precipitation were downloaded from the Online Isotopes in Precipitation Calculator (OIPC; Bowen and Revenaugh, 2003, Bowen, 2017), and then, a zoning map of hydrogen stable isotopes of precipitation in mainland China was constructed using ArcGIS 10.4.1 (Esri, Redlands, CA, USA). The wings of 284 L. dispar adults captured in five regions in China were selected as experimental samples. A Finnigan Delta V Advantage Isotope Ratio Mass Spectrometer (Thermo Fisher Scientific, Inc., Waltham, Massachusetts, U.S.) and a Flash 2000 HT Elemental Analyzer (Thermo Fisher Scientific, Inc., Waltham, Massachusetts, U.S.) were used to measure the hydrogen stable isotope (δ2H) value of the samples. Then, using the recorded local precipitation hydrogen stable isotope of the sampling site, we performed a data simulation using R software (v.3.2.1; R Development Core Team, Vienna, Austria). A linear regression equation was next established: y = 1.186x − 13.247, where x represents the hydrogen stable isotope ratio of precipitation and y denotes the hydrogen stable isotope ratio of L. dispar. The t-test, F-test, and R2 test results confirmed the high significance and matching with the simulation data used in the model. To further verify the accuracy of the model, L. dispar samples from Chengdu in Sichuan Province were collected for model back-testing. The verification results also evidenced that the actual source of the L. dispar sample can be obtained based on the method applied and the model developed in this paper.

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Altman, Douglas G. "Medical uses of statistics. John C. Bailar, III, and Frederick Mosteller (eds), Nejm books, Waltham mass., 1986. no. of pages: 425. price: £20." Statistics in Medicine 7, no. 9 (September 1988): 1001. http://dx.doi.org/10.1002/sim.4780070912.

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Ligouri, Gianna, Todd Shoepe, and Hawley Almstedt. "Whole Body Vibration Training is Osteogenic at the Spine in College-Age Men and Women." Journal of Human Kinetics 31, no. 1 (March 1, 2012): 55–68. http://dx.doi.org/10.2478/v10078-012-0006-8.

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Whole Body Vibration Training is Osteogenic at the Spine in College-Age Men and WomenOsteoporosis is a chronic skeletal disease characterized by low bone mass which is currently challenging the American health care system. Maximizing peak bone mass early in life is a cost-effective method for preventing osteoporosis. Whole body vibration (WBV) is a novel exercise method with the potential to increase bone mass, therefore optimizing peak bone and decreasing the risk for osteoporotic fracture. The aim of this investigation was to evaluate changes in bone mineral density at the hip, spine, and whole body in college-age men and women who underwent a WBV training protocol. Active men (n=6) and women (n=4), ages 18-22 participated in the WBV training; while an additional 14 volunteers (1 male, 13 female) served as controls. All participants completed baseline and follow-up questionnaires to assess health history, physical activity, dietary intake, and menstrual history. The WBV training program, using a Vibraflex 550, incorporated squats, stiff-leg dead lifts, stationary lunges, push-up holds, bent-over rows, and jumps performed on the platform, and occurred 3 times a week, for 12 weeks. Dual energy x-ray absorptiometry (Hologic Explorer, Waltham, MA, USA) was used to assess bone mineral density (BMD, g/cm2). A two-tailed, t-test identified significantly different changes in BMD between the WBV and control groups at the lateral spine (average change of 0.022 vs. -0.015 g/cm2). The WBV group experienced a 2.7% and 1.0% increase in BMD in the lateral spine and posterior-anterior spine while the control group decreased 1.9% and 0.9%, respectively. Results indicate that 12 weeks of WBV training was osteogenic at the spine in college-age men and women.

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Wrigley, C. C. "Medicine, Tradition and Development in Kenya and Tanzania, 1920–1970. By Ann Beck. Waltham, Mass.: Crossroads Press, 1981. Pp. viii + 114. No price stated." Journal of African History 26, no. 4 (October 1985): 441–42. http://dx.doi.org/10.1017/s0021853700029042.

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Vittum, P. J. "Efficacy of Several Turf Insecticides Against European Chafer Larvae, Home Lawn, 1995." Arthropod Management Tests 21, no. 1 (January 1, 1996): 366. http://dx.doi.org/10.1093/amt/21.1.366.

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Abstract Six turf insec-ticides were tested for efficacy against European chafer larvae on a home lawn in Waltham, Mass. Grub populations were ca. 60% eggs, 40% early first instar at the time of application. The lawn consisted of 30% perennial ryegrass, 30% annual bluegrass, 30% crabgrass, and 10% dandelion, and was mowed at ca. 1.5 inches. Treatment plots were 8 ft by 8 ft, replicated 5 times, arranged in a RCB. All applications were made between 11:00 AM and 12:30 PM on 1 Aug 95. Liquid formulations were applied by hand with a watering can, 3 liters per plot. Granular formulations were applied using glass jars with perforated lids. Conditions at the time of application were as follows: air temp. 85° F, sunny and moderately humid with light SW wind (5-10 mph); soil type, silty loam; soil pH 6.6; water pH, 8.2. All plots were hand watered with 0.1 inch immediately after application, and an additional 0.2 inch was applied through overhead irrigation within 2 hr after application. No measurable rain fell in the area for 2 wk after application. Product efficacy was evaluated on 17 Oct (77 DAT) by removing 5 cupcutter plugs (4.25 inch diam) from near the center of each plot, dislodging soil with a hand trowel, and counting all grubs to a depth of 3 inches.

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Nanco, Carrol R., Justin L. Poklis, Marzena M. Hiler, Alison B. Breland, Thomas Eissenberg, and Carl E. Wolf. "An Ultra-High-Pressure Liquid Chromatographic Tandem Mass Spectrometry Method for the Analysis of Benzoyl Ester Derivatized Glycols and Glycerol." Journal of Analytical Toxicology 43, no. 9 (August 21, 2019): 720–25. http://dx.doi.org/10.1093/jat/bkz071.

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Abstract Presented is an ultra-high-pressure liquid chromatographic tandem mass spectrometry (UPLC–MS/MS) method developed for the detection of propylene glycol, glycerol, ethylene glycol and diethylene glycol using isotopically labeled standards in urine as part of ongoing studies to evaluate whether urinary propylene glycol and/or vegetable glycerin concentration are indicators of recent use. Propylene glycol and vegetable glycerol are found in many products that are consumed and used including electronic cigarettes (e-cigarettes). E-cigarettes are battery-powered devices used as an alternative to traditional cigarettes. The liquid formulations aerosolized in these devices largely consist of propylene glycol and/or vegetable glycerol. Published reports regarding the ratio of propylene glycol to glycerol content in these formulations ranged from 50:50 to 100 percent of either. For the analysis of urine specimens from both users and non-users of e-cigarettes, calibrators, controls and specimens were derivatized using benzoyl chloride prior to analysis. They were analyzed using a Waters AcQuity Xevo TQ-S Micro UPLC–MS/MS. Chromatographic separation was performed on an AcQuity UPLC BEH C18 1.7 um, 2.1 × 50 mm, column using a 20 mM ammonium formate in water and 20 mM ammonium formate in methanol as the mobile phase. The method was validated using SWGTOX guidelines for linearity, precision and accuracy, stability, carryover and limit of detection. The linear range was determined using a seven-point calibration curve ranging between 0.5 and 100 mcg/mL. The bias for all validation controls was determined to be ±20% of the expected concentrations with CVs of <15%. A total of 124 urine specimens analyzed collected with 50 specimens collected from self-reported non-smokers (cigarettes/e-cigarettes) confirmed cotinine free using the DRI® Cotinine Assay (Thermo Scientific, Waltham, MA) and 74 specimens collected before and after 12 hours self-reported e-cigarettes abstinence e-cigarette users. Propylene glycol and glycerol were determined to have concentration ranges of “none detected” to 1470 and “none detected” to 2950 mcg/mL, respectively.

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Hershenzon, Daniel. "Sanjay Subrahmanyam, Three Ways to Be Alien: Travails and Encounters in the Early Modern World. Waltham, Mass.: The Menahem Stern Jerusalem Lectures, Brandeis University Press, 2011." Comparative Studies in Society and History 55, no. 2 (April 2013): 511–12. http://dx.doi.org/10.1017/s0010417513000145.

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Mjagkij, Nina. "All‐Out for Victory! Magazine Advertising and the World War II Home Front. By John Bush Jones. (Waltham, Mass.: Brandeis University Press, 2009. Pp.xi, 314. $50.00.)." Historian 73, no. 2 (June 1, 2011): 351–52. http://dx.doi.org/10.1111/j.1540-6563.2011.00294_26.x.

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Fuller, N. J., J. C. K. Wells, and M. Elia. "Evaluation of a model for total body protein mass based on dual-energy X-ray absorptiometry: comparison with a reference four-component model." British Journal of Nutrition 86, no. 1 (July 2001): 45–52. http://dx.doi.org/10.1079/bjn2001387.

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The aim of the present study was to evaluate a model of body composition for assessing total body protein (TBP) mass using dual-energy X-ray absorptiometry (DXA), with either measured or assumed total body water (TBW); it was intended to provide a less complex or demanding alternative technique to, for example, the four-component model (4-CM). The following measurements were obtained in healthy adults (n46) aged 18–62 years, and children (n30) aged 8–12 years: body weight (BWt), body volume (BV; under-water weighing), TBW (2H-dilution space or predicted using an assumed hydration fraction of fat-free mass (HFffm)), bone mineral content (BMC; DXA) and fat-free soft tissue (FFST; DXA). TBP was calculated using the 4-CM (TBP=3·050BWt-0·290TBW-2·734BMC-2·747BV) and the DXA model (TBP=FFST-0·2305BMC-TBW). DXA measurements were obtained using the Lunar DPX (Lunar Radiation Corporation, Madison, WI, USA) or Hologic QDR 1000/W (Hologic, Waltham, MA, USA). Precision of the DXA model for TBP with measured TBW (4·6–6·8 % mean TBP) was slightly worse than the 4-CM (4·0–5·4 %), whereas that modelled with assumed HFffmwas more precise (2·4–5·2 %) because it obviated imprecision associated with measuring TBW. Agreement between the 4-CM and DXA model with measured TBW was also worse (e.g. bias, 15 % of the mean; 95 % limits of agreement up to ±39 % for adults measured on the Lunar DPX) than when a constant for HFffmwas assumed (3·7 % and ±21 % respectively). Most of the variability in agreement between these various models was due to interpretation of biological factors, rather than to measurement imprecision. Therefore, the DXA model, which is less complex and demanding than the 4-CM, is of value for assessing TBP in groups of healthy subjects, but is of less value for individuals in whom there may be substantial differences from reference 4-CM estimates.

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Beller, Steven. "Robert Nemes, and Daniel Unowsky , eds. Sites of European Antisemitism in the Age of Mass Politics, 1880–1918. Afterword by Hillel J. Kieval . Waltham: Brandeis University Press, 2014. Pp. 345, maps, illus." Austrian History Yearbook 47 (April 2016): 223–24. http://dx.doi.org/10.1017/s0067237816000333.

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Eisenberg, Laura Zittrain. "Asher Susser, Israel, Jordan, and Palestine: The Two-State Imperative, Middle East Studies (Waltham, Mass.: Brandeis University Press, 2011). Pp. 312. $85.00 cloth, $29.95 paper, $27.99 e-book." International Journal of Middle East Studies 45, no. 4 (October 15, 2013): 846–47. http://dx.doi.org/10.1017/s002074381300113x.

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Prais, Lea. "Jewish Families in Europe, 1939-Present: History, Representation, and Memory. Ed. Joanna Beata Michlic. Waltham, Mass.: Brandeis University Press, 2017. xxxiv, 272 pp. Notes. Bibliography. Index. $40.00, paper." Slavic Review 77, no. 2 (2018): 494–95. http://dx.doi.org/10.1017/slr.2018.145.

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Hajduk, John C. "The Songs that Fought the War: Popular Music and the Home Front, 1939–1945. By John Bush Jones. (Waltham, Mass.: Brandeis University Press, 2006. Pp. xiv, 338. $29.95.)." Historian 70, no. 3 (September 1, 2008): 542–43. http://dx.doi.org/10.1111/j.1540-6563.2008.00221_19.x.

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Hirschhorn, Sara Yael. "Orit Rozin, The Rise of the Individual in 1950s Israel: A Challenge to Collectivism, trans. Haim Watzman (Waltham, Mass.: Brandeis University Press, 2011). Pp. 272. $85.00 cloth, $35.00 paper." International Journal of Middle East Studies 46, no. 2 (April 10, 2014): 401–3. http://dx.doi.org/10.1017/s0020743814000233.

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Maltais, Mélanie, Diane Brisson, and Daniel Gaudet. "Non-Alcoholic Fatty Liver in Patients with Chylomicronemia." Journal of Clinical Medicine 10, no. 4 (February 9, 2021): 669. http://dx.doi.org/10.3390/jcm10040669.

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Non-alcoholic fatty liver disease (NAFLD) is frequent in patients with features of the metabolic syndrome (MetS), obesity, or type 2 diabetes. Lipoprotein lipase (LPL) is the main driver of triglyceride (TG) hydrolysis in chylomicrons and very-low density lipoproteins (VLDL). In some patients with MetS, dysfunction of this pathway can lead to plasma TG values > 10 mmol/L (multifactorial chylomicronemia or MCS). Chylomicronemia also characterizes LPL deficiency (LPLD), a rare autosomal recessive disease called familial chylomicronemia syndrome (FCS), which is associated with an increased risk of recurrent pancreatitis. This study aims to investigate the expression of NAFLD, as assessed by transient elastography, in MCS and FCS subjects. Data were obtained from 38 subjects with chylomicronemia; 19 genetically confirmed FCS and 19 sex- and age-matched MCS. All participants underwent liver ultrasonography and stiffness measurement after a 4-h fast using transient elastography (FibroScan®, Echosens, Waltham, MA, USA). NAFLD (controlled attenuation parameter (CAP) > 280 dB/m) was observed in 42.1% of FCS and 73.7% of MCS subjects (p = 0.05). FCS subjects had lower body mass index (BMI) than MCS. Only 25% of FCS subjects with NAFLD had a BMI ≥ 30 compared to 64.3% in MCS (p = 0.004). In FCS, NAFLD occurred even in the presence of very low (≤18 kg/m2) BMI. In both FCS and MCS, CAP was negatively associated with acute pancreatitis risk. In this study, NAFLD was commonly observed in both FCS and MCS subjects and occurred independently of the BMI and fasting glucose values in FCS; NAFLD was associated with a lower occurrence of acute pancreatitis episodes.

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Leiby, David A., Silvano Wendel, Deise T. Takaoka, Roberta M. Fachini, Lea C. Oliveira, and Melinda A. Tibbals. "Serologic Testing for Trypanosoma cruzi: Comparison of Radioimmunoprecipitation Assay with Commercially Available Indirect Immunofluorescence Assay, Indirect Hemagglutination Assay, and Enzyme-Linked Immunosorbent Assay Kits." Journal of Clinical Microbiology 38, no. 2 (2000): 639–42. http://dx.doi.org/10.1128/jcm.38.2.639-642.2000.

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The radioimmunoprecipitation assay (RIPA) has been used as a confirmatory test in several ongoing and published studies ofTrypanosoma cruzi in blood donors in the United States. Despite its use as a confirmatory test, few studies are available comparing RIPA to commercially available serologic test methods. Thus, we compared RIPA with two indirect hemagglutination assays (Biolab Diagnostica SA, São Paulo, Brazil; Hemagen Diagnostics, Inc., Waltham, Mass.) and four different enzyme-linked immunosorbent assays (Abbott Laboratories, Abbott Park, Ill.; Embrabio, São Paulo, Brazil; Organon Teknika, São Paulo, Brazil; and Gull Laboratories, Salt Lake City, Utah) using a panel of 220 serum specimens from Brazilian blood donors with a range of T. cruzi antibody titers as determined by indirect immunofluorescence assay (IFA). A titer of 1:20 was used as the baseline for seropositivity. All IFA-negative serum specimens (n = 19) were nonreactive on all tests. At a titer of 1:20 (n = 9), reactivity rates varied considerably among the tests, with only the RIPA and the Organon and Gull assays identifying reactive specimens. For specimens at a 1:40 titer (n = 35), most assays identified at least 32 of 35 (91%) specimens as reactive, but the Biolab assay only identified 24 (69%). At higher titers (1:80, n = 56; 1:160,n = 101) the assays were comparable, with the exception of the Biolab assay, demonstrating rates of agreement with IFA of ≥98%. Overall, when compared with several other test formats, RIPA demonstrated equivalent or superior rates of agreement with IFA-positive specimens across all titers examined. In particular, at titers of >1:40, the RIPA compared favorably with other test methods currently in use, supporting its application as a confirmatory test, particularly in a research setting.

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Stanger, Howard R. "Louis Bamberger: Department Store Innovator and Philanthropist. By Linda B. Forgosh . Waltham, Mass.: Brandeis University Press, 2016. xv + 258 pp. Illustrations, notes, index. Cloth, $29.95. ISBN: 978-1-61168-981-5." Business History Review 91, no. 2 (2017): 417–19. http://dx.doi.org/10.1017/s0007680517000885.

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Israel, S., M. Ernst, O. E. Psathaki, H. C. Drexler, E. Casser, Y. Suzuki, W. Makalowski, G. Fuellen, M. Boiani, and L. Taher. "66 Unexpected Protein Dynamics During the Oocyte-to-Embryo Transition in Mice: a Mass Spectrometry and RNA Sequencing Tandem Study." Reproduction, Fertility and Development 30, no. 1 (2018): 172. http://dx.doi.org/10.1071/rdv30n1ab66.

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The development of a zygote from fertilization through implantation is orchestrated by a series of changes in gene expression at the RNA and protein levels. In mice, the hexagonal-shaped free ribosomes that translate mRNAs into proteins are rare during cleavage and only become abundant at the morula-blastocyst stage. Thus, how well can we understand development by an analysis of transcripts as proxy for the proteins? This question led us to combine mass spectrometry with RNA sequencing, with a long-term aim to illuminate the functional interconnection between transcriptome, proteome, and morphogenetic transitions in mouse embryos. To obtain cellular material in sufficient numbers for a proteomic approach, we recovered B6C3F1 × CD1 fertilized oocytes in vivo after ovarian stimulation, and cultured them in KSOM(aa) medium under 5% CO2 in air. We collected unfertilized oocytes and embryos from 6 pre-implantation developmental stages (pronuclear oocyte, 2-cell embryo, 4-cell embryo, 8-cell embryo, advanced morula, and blastocyst) in triplicates (600 oocytes or embryos per replicate). The protein lysates of these samples were added with equimolar amounts of isotopically labelled F9 embryonal carcinoma cells, resulting in light/heavy (L/H) protein mixtures. These were analysed using LTQ Orbitrap (Thermo Fisher Scientific, Waltham, MA, USA) and Q-Exactive (Thermo Fisher Scientific) instruments to yield L/H ratios for each measured protein, which were compared to transcript levels measured by RNA sequencing using an Illumina HiSEqn 2500 platform (100 oocytes or embryos per replicate; Illumina Inc., San Diego, CA, USA). All statistical analyses were performed in R (https://www.r-project.org/). Collectively, 6976 proteins were detected in at least the F9 cells (precondition for quantifying the L/H ratios in oocytes or embryos). In particular, 4991 proteins were detected in all developmental stages, and 1893 proteins were detected in all replicates. Spearman correlation analysis of each stage relative to unfertilized oocyte revealed distinct proteome and transcriptome developmental profiles. Furthermore, hierarchical clustering of the proteomes identified 2 main clusters (cluster 1: oocyte to 16-cell embryo; cluster 2: blastocyst), which are different from the well-known clusters of the transcriptomes (cluster 1: oocyte to 2-cell embryo; cluster 2: 4-cell embryo to blastocyst). Functional analysis of the genes that are differently expressed across adjacent stages highlighted the developmental roles of DNA damage response and Wnt signalling among the proteins and metabolism and translation among the RNAs. Our data provide new insight into the regulation of the transition from the differentiated oocyte into the embryo, highlighting the different gene identities and different biological processes featured by the proteins that change quantitatively across consecutive developmental stages, compared with mRNAs. The status of the mouse as model system in developmental biology is enriched with a protein dimension, and caution is called for in the use of transcript dynamics as proxy for protein dynamics.

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Haiduc-Dale, Noah. "Abigail Jacobson and Moshe Naor, Oriental Neighbors: Middle Eastern Jews and Arabs in Mandatory Palestine, Schusterman Series in Israel Studies (Waltham, Mass.: Brandeis University Press, 2016). Pp. 269. $35.00 paper. ISBN: 9781512600063." International Journal of Middle East Studies 50, no. 4 (November 2018): 808–10. http://dx.doi.org/10.1017/s002074381800106x.

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Diner, Hasia R. "Jonathan B. Krasner . The Benderly Boys and American Jewish Education . (Brandeis Series in American Jewish History, Culture, and Life.) Waltham, Mass.: Brandeis University Press. 2011. Pp. xii, 498. Cloth $95.00, paper $39.95." American Historical Review 117, no. 3 (June 2012): 889–90. http://dx.doi.org/10.1086/ahr.117.3.889.

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Davis, Christian S. "Sites of European Antisemitism in the Age of Mass Politics, 1880–1918. Edited by Robert Nemes and Daniel Unowsky. Waltham, MA: Brandeis University Press, 2014. Pp. ix + 345. Paper $40.00. ISBN 978-1611685824." Central European History 48, no. 4 (December 2015): 578–80. http://dx.doi.org/10.1017/s000893891500103x.

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Adler, Eliyana R. "A Jewish Woman of Distinction: The Life and Diaries of Zinaida Poliakova. By ChaeRan Freeze. Gregory Freeze, trans. Waltham, Mass: Brandeis University Press, 2019. Dist. University of Chicago Press. xvi, 396 pp. Notes. Appendix. Index. Photographs. Figures. Tables. Maps. $90.00, cloth." Slavic Review 80, no. 2 (2021): 427–28. http://dx.doi.org/10.1017/slr.2021.124.

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Sumner, G. "KIRSTEN FERMAGLICH. American Dreams and Nazi Nightmares: Early Holocaust Consciousness and Liberal America, 1957-1965. (Brandeis Series in American Jewish History, Culture, and Life.) Waltham, Mass.: Brandeis University Press. 2006. Pp. xii, 252. $29.95." American Historical Review 112, no. 4 (October 1, 2007): 1206–7. http://dx.doi.org/10.1086/ahr.112.4.1206.

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Bartov, O. "SAMUEL MOYN. A Holocaust Controversy: The Treblinka Affair in Postwar France. (The Tauber Institute for the Study of European Jewry Series.) Waltham, Mass.: Brandeis University Press. 2005. Pp. xxii, 220. Cloth $65.00, paper $19.95." American Historical Review 111, no. 3 (June 1, 2006): 914–15. http://dx.doi.org/10.1086/ahr.111.3.914.

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Hart, M. B. "IVAN DAVIDSON KALMAR and DEREK J. PENSLAR, editors. Orientalism and the Jews. (The Tauber Institute for the Study of European Jewry Series.) Waltham, Mass.: Brandeis University Press. 2005. Pp. xl, 285. Cloth $60.00, paper $26.00." American Historical Review 111, no. 1 (February 1, 2006): 131–32. http://dx.doi.org/10.1086/ahr.111.1.131.

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Whitfield, Stephen J. "Becoming American Jews: Temple Israel of Boston. By Meaghan Dwyer-Ryan, Susan L. Porter, and Lisa Fagin Davis. (Waltham, Mass.: Brandeis University Press/Lebanon, N.H.: University Press of New England, 2009. Pp. xvii, 259. $24.95 paper.)." New England Quarterly 83, no. 2 (June 2010): 344–47. http://dx.doi.org/10.1162/tneq.2010.83.2.344.

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Daniel, Yvonne, Charles Turner, Lisa Farrar, and R. Neil Dalton. "A Comparison of IEF and MSMS for Clinical Hemoglobinopathy Screening in 40,000 Newborns." Blood 112, no. 11 (November 16, 2008): 2387. http://dx.doi.org/10.1182/blood.v112.11.2387.2387.

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Abstract Currently, newborn haemoglobinopathy screening is carried out using HPLC or isoelectric focusing (IEF). We have previously described a rapid and specific electrospray mass spectrometry–mass spectrometry (MSMS) technique, using multiple reaction monitoring (MRM) based peptide analysis, for simultaneous detection of the clinically significant haemoglobinpathies; haemoglobin (Hb)S, HbC, HbE, HbDPunjab and HbOArab. Here we report the results of a comparison of 40,000 newborn blood spots screened by both IEF and MSMS. For both IEF and MSMS analysis, blood spots (3.2mm) were punched into separate 96 well plates. IEF was performed using the Resolve haemoglobin test kit (PerkinElmer Life Sciences, Waltham, USA) and Isoscan imaging system. For MSMS analysis, the blood spots were digested for 30min at 37°C with a trypsin reagent, and diluted in mobile phase (acetonitrile: water, 50:50, with 0.025% formic acid. Sample, 2μl, was injected directly into the mobile phase (flow rate 80μl/min) and analysed, in positive ion mode, using a Sciex API4000 (Applied Biosystems, Warrington, UK). Specific MRM transitions for HbS, HbC, HbE, HbDPunjab, HbOArab, normal beta, alpha, gamma and delta chains were acquired; total acquisition time per sample was 60 sec. This enabled identification of sickling disorders and thalassaemia major, as well as assessment of transfusion state and potential identification of HbLepore and HbBarts. 40,000 blood spot samples for routine newborn haemoglobinopathy screening were analysed in parallel. HbS was detected in 199 samples; 8 were HbS/HbF only and 3 HbSC. HbC was detected in 39 samples, HbDPunjab in 52, HbE in 48. No HbOArab or HbLepore mutations were detected by either method. There have been no discrepancies between the analytical techniques. Using MSMS, mutation positive samples can be re-run in product ion scan mode to provide peptide sequence and hence unequivocal confirmation of the haemoglobin variant. In addition, 5,000 samples were analysed on a Sciex API4000 Q trap; using the information dependent acquisition facility provided “real time” peptide sequencing thus removing the requirement for re-injection. Sample preparation is very quick and simple for both methods, but the consumable costs associated with the MSMS technique are <10% of those for IEF. The capital cost of MSMS can be offset by high throughput and/or integration with current inherited metabolic disease screening by MSMS. The specificity of the MSMS analysis implies that haemoglobinopathy detection can be limited to specified conditions, based on agreed screening policy, and can eliminate the need for costly and time consuming second line testing. This study demonstrates that newborn haemoglobinopathy screening can be carried out rapidly, easily, and cost effectively using MSMS technology. It enables rationalisation of technology platforms in newborn screening by consolidating screening for haemoglobinopathies and inherited metabolic diseases onto MSMS.

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Pinzon, C. A., M. Snyder, J. Pryor, B. Thompson, M. Golding, and C. Long. "207 EFFICIENT GENERATION OF MYOSTATIN PROMOTER MUTATIONS IN BOVINE EMBRYOS USING THE CRISPR/Cas9 SYSTEM." Reproduction, Fertility and Development 29, no. 1 (2017): 212. http://dx.doi.org/10.1071/rdv29n1ab207.

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The myostatin gene or growth differentiation factor 8 is a member of the transforming growth factor-β superfamily that acts as a negative regulator of muscle growth. Mutations inactivating this gene occur naturally in Piedmontese and Belgian Blue cattle breeds, resulting in a dramatic increase in muscle mass, albeit with unwanted consequences of increased dystocia and decreased fertility. Modulation of muscle mass increase without the unwanted effects would be of great value for improving livestock growth and economic value of livestock. The objective of our work was to use the CRISPR-Cas9 genetic engineering tool to generate deletions of different elements in the myostatin promoter in order to decrease the level of expression and obtain an attenuated phenotype without the detrimental consequences of an inactivating mutation. To achieve this objective 4 different small guide RNA (sgRNA) targeting the promoter near the mutation were designed with PAM positions from transcription starting site of −1577, −689, −555, and −116. These sgRNA were cloned individually into the Cas9 plasmids (px461, and px462; Addgene®). These plasmids allow for a dual puromycin resistance (px462) and green fluorescent protein (px461) selection. We first tested the functionality of these sgRNA in vitro by co-transfecting bovine fetal fibroblasts with a combination of both plasmids (Set 1 = sgRNA 1–4; Set 2 = sgRNA 2–3). Cells were exposed to puromycin (0.2 µg mL−1) for 72 h, then single and mixed colonies positive for green fluorescent protein expression were separated for propagation. The DNA was extracted for PCR amplification of the targeted region. Multiple deletions and a few insertion events were observed after PCR, bands were cloned into TOPO® vector (Thermo Fisher Scientific, Waltham, MA, USA) and sequenced. Sequencing results confirmed the PCR products as insertions or deletions in the myostatin promoter region. We proceeded to modify the myostatin promoter directly in bovine zygotes. For this, IVF-derived zygotes were randomly assigned to 3 different treatment groups Set 1, Set 2, or Null (no sgRNA) for microinjections. Each zygote was injected with ~100 pL of trophectoderm buffer containing 50 ng µL−1 of total sgRNA, 10 ng µL−1 of Cas9 mRNA, and 30 ng µL−1 of Cas9 protein with 1 mg mL−1 of fluorescent dextran. Day 7 post-IVF blastocysts were lysed and DNA was extracted for PCR amplification of the target region. In Set 1, 16 of 19 embryos (94.12%) were successfully edited, whereas in Set 2 there were 11 of 17 embryos (64.7%) edited. In both sets of sgRNA there was a high degree of mosaicism, with only 1 embryo demonstrating a homozygous deletion. In conclusion, CRISPR/Cas9 acts over the course of the first few cleavage divisions Further research is necessary to refine the CRISPR/Cas9 system for inducing genetic mutations in bovine embryos.

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Pasquariello, R., Y. Yuan, D. Logsdon, J. Becker, L. Yao, C. Broeckling, W. B. Schoolcraft, J. P. Barfield, and R. L. Krisher. "62 Sequential nutrient restriction and provision during bovine in vitro embryo culture differentially affect blastocyst development and quality with oocytes from varied sources." Reproduction, Fertility and Development 31, no. 1 (2019): 156. http://dx.doi.org/10.1071/rdv31n1ab62.

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We have demonstrated that bovine blastocyst development was improved after culture in medium with only 6.25% of standard carbohydrate and amino acid concentrations, supplemented with fatty acids. However, these blastocysts had lower cell numbers. We hypothesised that this was due to deficiencies in embryo metabolism at the time of blastocyst formation. Thus, our objectives were to (1) determine whether using a sequential combination of nutrient concentrations could rescue blastocyst cell number; and (2) investigate the efficacy of reduced nutrient medium in 2 sources of oocytes. Oocytes were in vitro matured in identical medium either in our laboratory or during shipment from a commercial supplier. Oocytes in our laboratory were derived from feedlot heifers while purchased oocytes were obtained from culled cows. Zygotes were cultured using sequential medium with fraction V BSA. In step 1/step 2, embryos were cultured using 100% (glucose 0.5 mM/fructose 3.0mM, pyruvate 0.3/0.1mM, lactate 10.0/6.0mM, NEEA 1×/1× MEM, EAA 0.25×/0.5× MEM), 25% or 6.25% of standard nutrient concentrations. On Day 3, embryos were moved to step 2 as follows: 100% to 100%, 25% to 25%, 25% to 100%, 6.25% to 25%, or 6.25% to 100%. Lipid content of single mature oocytes from both sources was determined using gas chromatography coupled to an ISQ-LT MS/MS (GC-MS; Thermo Scientific, Waltham, MA, USA). Data (mean±s.e.m.) were analysed using ANOVA (P<0.05). When oocytes from feedlot heifers were used, blastocyst development and cell number did not differ between treatments. When oocytes from culled cows were used, blastocyst development was improved after embryo culture in 25-25% (45.1±3.3%) and 6.25-25% (46.6±3.2%) compared with 100-100% (34.2±3.2%). However, inner cell mass number of blastocysts cultured in 25-25% (25.6±2.5) and 6.25-25% (26.0±2.6) was reduced compared with 100-100% (41.4±4.5); TE and total cell number did not differ. Embryos cultured in 100-100%, 25-100%, and 6.25-100% were equivalent. Metabolomics revealed that 10 lipid compounds (polyunsaturated fatty acids, glycosyldiacylglycerols, and glycerophospholipids) differed in abundance between the two sources of oocytes. These results show that oocytes from different sources lead to different experimental outcomes, likely due to a combination of age, body condition, diet, and hormone treatment of the female. Oocytes from culled cows result in embryos that develop to blastocysts better in a reduced nutrient environment, although these embryos have fewer inner cell masses, suggesting that quality may be reduced. Embryos from feedlot heifer oocytes are relatively immune to nutrient fluctuations. Different endogenous fatty acid reserves in the oocyte may lead to differing metabolic strategies in the subsequent embryo, altering their response to substrate availability during in vitro culture. These results also demonstrate that reduction of nutrients during culture has no detrimental effect on blastocyst development or total cell number in either oocyte source, but that inner cell mass formation requires increased nutrient provision.

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Rapaport, Lynn. "Nils Roemer . German City, Jewish Memory: The Story of Worms . (The Tauber Institute Series for the Study of European Jewry.) Waltham, Mass.: Brandeis University Press. Hanover, N.H.: University Press of New England. 2010. Pp. x, 316. Cloth $85.00, paper $35.00." American Historical Review 117, no. 2 (April 2012): 628–29. http://dx.doi.org/10.1086/ahr.117.2.628.

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Simon, R. "MARGALIT SHILO. Princess or Prisoner? Jewish Women in Jerusalem, 1840-1914. (Brandeis Series on Jewish Women and The Tauber Institute for the Study of European Jewry Series.) Waltham, Mass.: Brandeis University Press. 2005. Pp. xxviii, 330. Cloth $65.00, paper $29.95." American Historical Review 111, no. 2 (April 1, 2006): 594–95. http://dx.doi.org/10.1086/ahr.111.2.594.

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Deutsch, D. R., T. Fröhlich, K. A. Otte, A. Beck, F. A. Habermann, E. Wolf, and G. J. Arnold. "83 STAGE-SPECIFIC PROTEOME SIGNATURES IN EARLY BOVINE EMBRYO DEVELOPMENT." Reproduction, Fertility and Development 27, no. 1 (2015): 134. http://dx.doi.org/10.1071/rdv27n1ab83.

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Development of early embryonic stages before activation of the embryonic genome depends on sufficiently stored products of the maternal genome and adequate activation, deactivation, and relocation of proteins. To establish protein function, several posttranslational events (e.g. proteolytic activation, phosphorylation, or secretion) are frequently essential and thereby prevent prediction of protein abundance from transcript abundance. Consequently, proteomic studies are indispensable to characterise the molecular processes governing early embryonic development and to establish corresponding regulatory networks. Here, we present a quantitative proteome analysis of bovine zygotes and embryos at the 2-cell and 4-cell stage. Cumulus-oocyte complexes (COC) were prepared from bovine ovaries obtained from a local abattoir and selected for a compact layer of cumulus cells. In vitro maturation, fertilization, and embryo production were performed according to standard procedures. For quantitative isobaric tags for relative and absolute quantitation (iTRAQ)-liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis, protein from batches of 50 MII oocytes (serving as a reference), zygotes, 2-cell and 4-cell stage embryos, respectively, was extracted. Quantitative proteome analysis of iTRAQ-labelled tryptic peptides was performed on an Orbitrap XL instrument (Thermo Fisher, Waltham, MA, USA) coupled to an Eksigent nano-liquid chromatography system (AB Sciex, Framingham, MA, USA). The tandem MS data were analysed by MASCOT and filtered for a false discovery rate (FDR) of <1%. Quantification of iTRAQ signals was accomplished with the Q+ module of the Scaffold software (Proteome Software Inc., Portland, OR, USA). t-Tests, ANOVA and principal component analysis (PCA) analysis were performed using R (R Core Development Team, Vienna, Austria). From 4 biological replicates, 1072 proteins were identified and quantified. Eighty-seven differed significantly in abundance between the 4 stages (log2 fold change ≥ |0.6|, P ≤ 0.05). The proteomes of 2-cell and 4-cell embryos differed most from the reference MII oocyte, and a considerable fraction of proteins continuously increases in abundance during the stages analysed. Bioinformatic analysis of abundance altered proteins provided evidence that the proteins RPS14 and HNRNPK involved in the p53 pathway play a major role during early development, as well as proteins of the lipid metabolism, in particular APOA1. Furthermore, a group of proteins (e.g. SPTBN1, PPP1CC, RABGAP1, STMN1, and WEE2) is engaged in mitosis. In addition, we detected relevant differences between transcript and protein abundance levels; for example, for WEE2. In conclusion, this study identified and quantified numerous proteins important for early embryogenesis so far not described in the mammalian system, and contributed protein profiles for key players previously described. Our results highlight the importance of innovative proteomic tools and workflows to complement transcriptome data of early embryogenesis.

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Almeida, Cybele Crossetti de, and Daniele Gallindo Gonçalves Silva. "A poesia política de Walther von der Vogelweide e a Questão das Investiduras." Diálogos 20, no. 3 (September 1, 2016): 69. http://dx.doi.org/10.4025/dialogos.v20i3.33466.

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Tendo como base a produção poética de Walther von der Vogelweide, o presente artigo discute a representação da temática política nas cantigas do trovador alemão. Para tanto, propomos um diálogo entre Literatura e História, mais especificamente, entre as cantigas de Walther e a da Questão das Investiduras.

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Klarsfeld, André, Serge Birman, and François Rouyer. "L’horloge circadienne à l’heure Nobel." médecine/sciences 34, no. 5 (May 2018): 480–84. http://dx.doi.org/10.1051/medsci/20183405023.

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L’attribution du prix Nobel 2017 de physiologie ou médecine à trois chercheurs américains - Jeffrey C. Hall (né le 3 mai 1945 à New York – University of Maine), Michael Rosbash (né le 7 mars 1944 à Kansas City - Brandeis University, Waltham et Howard Hughes Medical Institute) et Michael W. Young (né le 28 mars 1949 à Miami - Rockefeller University, New York), est difficilement contestable, tant ces chercheurs incarnent depuis près de 35 ans, l’émergence, puis le foisonnement des études moléculaires et cellulaires des rythmes circadiens. Mais ce prix a fait bien plus que trois heureux. Il apporte, en effet, une reconnaissance éclatante à un domaine, la chronobiologie, qui a longtemps fait figure, au mieux pour certains, d’aimable curiosité… La difficulté à identifier les rouages des horloges biologiques qui rythment nos jours et nos nuits, ou même à seulement les imaginer, y a bien sûr contribué. C’est pourquoi les travaux de Hall, Rosbash et Young – récompensés « pour leurs découvertes des mécanismes moléculaires qui contrôlent les rythmes circadiens » – ont revêtu une telle importance, même si la voie leur avait été ouverte un peu plus d’une décennie auparavant. Paradoxalement, le grand public a peut-être admis l’existence de nos horloges internes avant la communauté scientifique, car chacun peut faire l’expérience intime de rythmes journaliers, à commencer par l’alternance veille-sommeil, qui s’imposent à lui !

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Walther, Paul, and Martin Müller. "Low-temperature field-emission scanning electron microscopy of high-pressure frozen samples reveals structural information below 10 nm." Proceedings, annual meeting, Electron Microscopy Society of America 54 (August 11, 1996): 826–27. http://dx.doi.org/10.1017/s0424820100166592.

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High-pressure-frozen samples can be imaged in the frozen hydrated state with a low temperature scanning electron microscope (LTSEM) thereby preventing many of the fixation and drying artifacts related to chemical fixation and dehydration. One limiting factor of high resolution LTSEM, however, is mass loss of the hydrated specimen due to electron beam irradiation. This effect is significantly reduced by using double layer coating and backscattered electron imaging (Walther et al., 1995). Thereby the sample is first coated with a contrast forming heavy metal layer (1 - 3 nm thick) and afterwards with a stabilising carbon coat (5 - 10 nm; Walther and Hentschel, 1989). The heavy metal layer is imaged with backscattered electrons that penetrate the carbon layer. Using this method structural information comparable to the TEM-replica (“freeze-etch”) technique can be achieved, without the need of replica cleaning. The method has been especially useful for samples where replica cleaning is difficult; e. g. investigation of new materials for filling cavities in dentistry, or the effects of drug application to human skin, or investigation of new materials in polymer science.

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Kloot, W. van Der. "April 1915: Five future Nobel Prize–winners inaugurate weapons of mass destruction and the academic–industrial–military complex." Notes and Records of the Royal Society of London 58, no. 2 (May 22, 2004): 149–60. http://dx.doi.org/10.1098/rsnr.2004.0053.

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Poison gas warfare was initiated in the Great War by a German military unit that included five future Nobel laureates: James Franck, Fritz Haber, Otto Hahn, Gustav Hertz and Walther Nernst. It was Haber's idea to use poison gas. To implement gas warfare he devised an organization that meshed the academy into the military–industrial complex. Later three other Nobel laureates, Emil Fischer, Heinrich Wieland and Richard Willstätter, contributed to the enterprise. Huge quantities of poisons were used by both sides during the war, because they were well adapted to static trench warfare, even though—which is a surprise to many—they were substantially less deadly than explosives.

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Rodrigues, Victor César Fernandes. "WALTAR BENJAMIN, TEÓRICO DO TRANSUMANISMO?" Sapere Aude 10, no. 20 (December 22, 2019): 634–61. http://dx.doi.org/10.5752/p.2177-6342.2019v10n20p634-661.

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O presente artigo tem a pretensão de oferecer uma interpretação possível acerca de alguns postulados de Benjamin acerca do capitalismo como religião, tentando vincular o tema do transumanismo da singularidade como uma de suas contrapartes ilustrativas, mas de modo algum única. Mapearemos parte por parte do fragmento de O capitalismo como religião, tentando sondar as aberturas que suscitem essa determinada articulação. Em seguida, faremos um apanhado extremamente pontual acerca da filosofia do movimento transumanista, dando especial ênfase ao transumanismo da singularidade, como uma das versões do movimento segundo a qual mais nos parece afim com o caráter antecipatório na visão de Benjamin acerca da “religião do capital”, demonstrando haver certos nexos reflexivos com a “religião da máquina” propagandeada por essa vertente e, essencialmente, da versão com que a fusão entre humanos e máquinas encampa seus discursos.

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Gong, L., M. Pachner, K. Kalai, and T. Lelley. "SSR-based genetic linkage map of Cucurbita moschata and its synteny with Cucurbita pepo." Genome 51, no. 11 (November 2008): 878–87. http://dx.doi.org/10.1139/g08-072.

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The first SSR-based genetic linkage map of Cucurbita moschata was created by integrating the maps of two F2 populations with one common parent developed from the crosses Waltham Butternut (WB) × Nigerian Local (NL) and ZHOU (a hull-less type) × WB. The integrated C. moschata map comprises 205 SSR markers and two morphological traits (Gr and n). The map is composed of 27 linkage groups with a marker density of 7 cM. Comparing the C. moschata map with the published Cucurbita pepo map, we found a high level of macrosynteny. Seventy-two of 76 common SSR markers between C. moschata and C. pepo were located in homologous linkage groups. These markers in general have conserved orders and similar genetic distances; they represent orthologous loci. A reference map based on these SSRs was obtained. No major chromosomal rearrangement between the two species could be detected at present, although four SSR markers were mapped in nonhomologous linkage groups. The comparative alignment of SSR markers did not provide any indication of a possible ancient polyploid origin of the species. The comparative mapping of C. moschata and C. pepo reported here will be useful for further studies on Cucurbit evolution, gene isolation, and breeding work.

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Grey, Thomas, and Kirsten Paige. "The Owl, the Nightingale and the Jew in the Thorn-bush: Relocating Anti-Semitism in Die Meistersinger." Cambridge Opera Journal 28, no. 1 (March 2016): 1–35. http://dx.doi.org/10.1017/s095458671600001x.

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AbstractFor the past twenty-five years a key piece of evidence for an anti-Semitic subtext in Wagner’s Die Meistersinger has been identified in the Grimm Brothers’ anti-Semitic tale ‘The Jew in the Thorn-bush’ and a possible allusion to this in the text of Walther’s Act I ‘trial song’. This article argues that the passages in question are better explained with reference to a medieval poetic tradition still prevalent in nineteenth-century German culture involving the vocal contest between birds, paradigmatically the owl and the nightingale. Since the twelfth century, the owl and the nightingale have debated the merits of high and low art, religious themes, social forms, poetic diction and more. The associations of pedantry and harsh, coarse vocal character with the figure of the owl maps readily onto the negative traits of Beckmesser, just as the contrasting associations of the melodious nightingale with springtime, courtship and ‘natural’ musicality align with traits of Wagner’s artist-hero, Walther von Stolzing. Rather than displacing the possible anti-Semitic reading of Beckmesser, however, this alternative reading of the Beckmesser–Walther antagonism through the lens of avian conflict or debate poetry relocates that reading within a broader discursive and figurative context, one that is more commensurate with the possible role of anti-Semitic subtexts within Wagner’s music dramas in general.

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Sugii, Mari Miura, Bruno de Castro Ferreira Barreto, Waldemir Francisco Vieira-Júnior, Katia Regina Izola Simone, Ataís Bacchi, and Ricardo Armini Caldas. "Extruded upper first molar intrusion: Comparison between unilateral and bilateral miniscrew anchorage." Dental Press Journal of Orthodontics 23, no. 1 (January 2018): 63–70. http://dx.doi.org/10.1590/2177-6709.23.1.063-070.oar.

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ABSTRACT Objective: The aim of his study was to evaluate the stress on tooth and alveolar bone caused by orthodontic intrusion forces in a supraerupted upper molar, by using a three-dimensional Finite Element Method (FEM). Methods: A superior maxillary segment was modeled in the software SolidWorks 2010 (SolidWorks Corporation, Waltham, MA, USA) containing: cortical and cancellous bone, supraerupted first molar, periodontal tissue and orthodontic components. A finite element model has simulated intrusion forces of 4N onto a tooth, directed to different mini-screw locations. Three different intrusion mechanics vectors were simulated: anchoring on a buccal mini-implant; anchoring on a palatal mini-implant and the association of both anchorage systems. All analyses were performed considering the minimum principal stress and total deformation. Qualitative analyses exhibited stress distribution by color maps. Quantitative analysis was performed with a specific software for reading and solving numerical equations (ANSYS Workbench 14, Ansys, Canonsburg, Pennsylvania, USA). Results: Intrusion forces applied from both sides (buccal and palatal) resulted in a more homogeneous stress distribution; no high peak of stress was detected and it has allowed a vertical resultant movement. Buccal or palatal single-sided forces resulted in concentrated stress zones with higher values and tooth tipping to respective force side. Conclusion: Unilateral forces promoted higher stress in root apex and higher dental tipping. The bilateral forces promoted better distribution without evidence of dental tipping. Bilateral intrusion technique suggested lower probability of root apex resorption.

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Nakano, T., K. Wada, M. Yamanaka, I. Kamiya, and H. Nakajima. "PRECURSORY SLOPE DEFORMATION AROUND LANDSLIDE AREA DETECTED BY INSAR THROUGHOUT JAPAN." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLI-B1 (June 6, 2016): 1201–5. http://dx.doi.org/10.5194/isprsarchives-xli-b1-1201-2016.

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Interferometric Synthetic Aperture Radar (InSAR) technique is able to detect a slope deformation around landslide (e.g., Singhroy et al., 2004; Une et al., 2008; Riedel and Walther, 2008; Sato et al., 2014). Geospatial Information Authority (GSI) of Japan has been performing the InSAR analysis regularly by using ALOS/PALSAR data and ALOS-2/PALSAR-2 data throughout Japan. There are a lot of small phase change sites except for crustal deformation with earthquake or volcano activity in the InSAR imagery. Most of the phase change sites are located in landslide area. We conducted field survey at the 10 sites of those phase change sites. As a result, we identified deformation of artificial structures or linear depressions caused by mass movement at the 9 sites. This result indicates that InSAR technique can detect on the continual deformation of landslide block for several years. GSI of Japan will continue to perform the InSAR analysis throughout Japan. Therefore, we will be able to observe and monitor precursory slope deformation around landslide areas throughout Japan.

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Nakano, T., K. Wada, M. Yamanaka, I. Kamiya, and H. Nakajima. "PRECURSORY SLOPE DEFORMATION AROUND LANDSLIDE AREA DETECTED BY INSAR THROUGHOUT JAPAN." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLI-B1 (June 6, 2016): 1201–5. http://dx.doi.org/10.5194/isprs-archives-xli-b1-1201-2016.

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Interferometric Synthetic Aperture Radar (InSAR) technique is able to detect a slope deformation around landslide (e.g., Singhroy et al., 2004; Une et al., 2008; Riedel and Walther, 2008; Sato et al., 2014). Geospatial Information Authority (GSI) of Japan has been performing the InSAR analysis regularly by using ALOS/PALSAR data and ALOS-2/PALSAR-2 data throughout Japan. There are a lot of small phase change sites except for crustal deformation with earthquake or volcano activity in the InSAR imagery. Most of the phase change sites are located in landslide area. We conducted field survey at the 10 sites of those phase change sites. As a result, we identified deformation of artificial structures or linear depressions caused by mass movement at the 9 sites. This result indicates that InSAR technique can detect on the continual deformation of landslide block for several years. GSI of Japan will continue to perform the InSAR analysis throughout Japan. Therefore, we will be able to observe and monitor precursory slope deformation around landslide areas throughout Japan.

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Lopes, Tomás de vilanova Monteiro. "Seleção de Pessoal." Revista do Serviço Público 94, no. 2 (October 31, 2017): 44–54. http://dx.doi.org/10.21874/rsp.v0i2.3014.

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No mundo moderno, em que se concebe o trabalho como uma das formas de realização da personalidade humana, a seleção de pessoal desempenha um papel de grande importância e, graças a ela, vêm sendo eliminadas algumas das principais causas do desajustamento profissional e suas graves consequências para o indivíduo, a família e a comunidade. Nos seus primórdios, a racionalização do trabalho era tarefa exclusiva do engenheiro, de cuja prancheta saíam máquinas cada Vez mais aperfeiçoadas, ou do químico que em suas retortas apurava a matéria-prima para dar-lhe características sempre melhores. A ideia de que os problemas da produção poderiam ser solucionados apenas com a melhoria dos equipamentos, dos processos de execução e dos materiais não tardou, porém, a revelar a sua inconsistência. Havia um outro fator a exigir cuidados e atenções especiais: a pessoa humana. A constatação desse fato marcou o início de uma nova fase no movimento de racionalização, trazendo para este a contribuição efetiva dos psicólogos, dos médicos e dos educadores. A verdadeira e mais atual filosofia da racionalização do trabalho está contida, por inteiro, nestas palavras de Leon Walther.

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Permanadewi, Indrasukma, Andri Cahyo Kumoro, Dyah Hesti Wardhani, and Nita Aryanti. "Mathematical Approach for Estimation of Alginate-Iron Salt Solutions Viscosity at Various Solid Concentrations and Temperatures." Current Research in Nutrition and Food Science Journal 9, no. 1 (April 27, 2021): 75–87. http://dx.doi.org/10.12944/crnfsj.9.1.08.

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Abstract:

Alginate has been widely used in the pharmaceutical industries as tablet binder and disintegrant, release agent and controlled release drug delivery system. Whereas in the food industries, alginate is generally employed as thickener, emulsifier, stabilizer, texturizer, formulation aid, firming agent, flavor adjuvant, and surface-active agent. As one of the important raw materials in the functional food preparation, iron is hard to manage due to its vulnerability to oxidization, degradation and possesses a strong unique aroma. Considering its superior coating and release properties, alginate gel can be the best choice to preserve iron from various undesirable effects. Unfortunately, there has been lack information in the published literature to estimate the effect of temperature, concentration, and stirring time on the mechanical properties of alginate. Although many mathematical models have been developed based on these factors to predict the viscosity of the alginate-Fe solutions used as feed in spray drying application, no clear information have been reported for their accuracy. This study aims to examine four physical models for their suitability in estimating alginate-Fe solution viscosity, namely the Walther, Mark Houwink, Vogel – Tamman – Fulcher (VTF), and Intrinsic models. Prior to model validation, alginate-Fe solutions containing alginate: Fe (2:1) mass ratio were prepared. They were heated to desirable temperatures (30°, 45°, 60°, and 75°C), stirred for various stirring times (0 to 60 minutes), and subjected to viscosity measurement. The results exhibited that the viscosity of alginate-Fe solution with 5% alginate concentration stirred for 15 minutes at 30°C reached 320 cP. Whereas the viscosity of Alginate-Fe solution with 1% (m/m) concentration at the same temperature and stirring time was only 250 cP. This observation suggested that a higher alginate solution concentration leads to a higher the viscosity. As expected, a higher temperature and longer stirring time resulted in the decline of the Alginate-Fe solution viscosity. Although the proposed models demonstrated the similar trend, it can be concluded that the Walther model was proven to be the most accurate model used for the prediction of the Alginate-Fe solution viscosity compared to the other models as shown by its highest R2 value, which was 0.987.

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Rose, Edward P. F. "The first hydrogeological and geological maps of Jersey, Channel Islands: work by Walther Klüpfel in 1942 and Richard Nelson c. 1828." Proceedings of the Geologists' Association 116, no. 2 (January 2005): 107–16. http://dx.doi.org/10.1016/s0016-7878(05)80002-1.

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Journal articles on the topic 'Waltham (Mass.)'

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