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1

MORI, Yoshitaka, Akira DEGUCHI, Hikoji SUZUKI, et al. "Coagulability in Watanabe heritable hyperlipidemic(WHHL) rabbit." Blood & Vessel 18, no. 5 (1987): 482–85. http://dx.doi.org/10.2491/jjsth1970.18.482.

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2

Naka, Yoshiko, Gen Yoshino, Tsutomu Hirano, et al. "Triglyceride metabolism in heterozygote of Watanabe heritable hyperlipidemic rabbit." Atherosclerosis 136, no. 2 (1998): 325–32. http://dx.doi.org/10.1016/s0021-9150(97)00235-9.

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3

Chobanian, A. V., C. C. Haudenschild, C. Nickerson, and S. Hope. "Trandolapril inhibits atherosclerosis in the Watanabe heritable hyperlipidemic rabbit." Hypertension 20, no. 4 (1992): 473–77. http://dx.doi.org/10.1161/01.hyp.20.4.473.

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4

Kouchi, Mami, Yoshinaka Ueda, Hiroshi Horie, and Kohji Tanaka. "Ocular lesions in Watanabe heritable hyperlipidemic rabbits." Veterinary Ophthalmology 9, no. 3 (2006): 145–48. http://dx.doi.org/10.1111/j.1463-5224.2006.00453.x.

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5

Chobanian, A. V., C. C. Haudenschild, C. Nickerson, and R. Drago. "Antiatherogenic effect of captopril in the Watanabe heritable hyperlipidemic rabbit." Hypertension 15, no. 3 (1990): 327–31. http://dx.doi.org/10.1161/01.hyp.15.3.327.

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6

Kurosawa, Takafumi, Yuxin Li, Takafumi Hiro, and Atsushi Hirayama. "EFFECTS OF RESVERATROL ON ATHEROSCLEROTIC LESIONS IN WATANABE HERITABLE HYPERLIPIDEMIC RABBIT." Journal of the American College of Cardiology 71, no. 11 (2018): A2100. http://dx.doi.org/10.1016/s0735-1097(18)32641-x.

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7

Robins, E. D., L. M. Nelson, and J. M. Hoeg. "Aberrant hypothalamic-pituitary-ovarian axis in the Watanabe heritable hyperlipidemic rabbit." Journal of Lipid Research 35, no. 1 (1994): 52–59. http://dx.doi.org/10.1016/s0022-2275(20)40127-0.

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8

Lichtenstein, A. H., and A. V. Chobanian. "Effect of fish oil on atherogenesis in Watanabe heritable hyperlipidemic rabbit." Arteriosclerosis: An Official Journal of the American Heart Association, Inc. 10, no. 4 (1990): 597–606. http://dx.doi.org/10.1161/01.atv.10.4.597.

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9

Hansen, Birgit Fischer, Alicja Mortensen, Jorgen Fischer Hansen, and Henrik Frandsen. "(–)-Anipamil Retards Atherosclerosis in Watanabe Heritable Hyperlipidemic Rabbits." Journal of Cardiovascular Pharmacology 26, no. 3 (1995): 485–89. http://dx.doi.org/10.1097/00005344-199509000-00020.

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10

Westenend, P. J., A. A. Kroon, A. F. H. Stalenhoef, and K. H. J. Assmann. "Absence of Glomerulosclerosis in Watanabe Heritable Hyperlipidemic Rabbits." Nephron 64, no. 1 (1993): 150–51. http://dx.doi.org/10.1159/000187297.

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11

Mori, Yoshitaka, Hideo Wada, Yutaka Nagano, Katsumi Deguch, Toru Kita, and Shigeru Shirakawa. "Hypercoagulable State in the Watanabe Heritable Hyperlipidemic Rabbit, an Animal Model for the Progression of Atherosclerosis." Thrombosis and Haemostasis 61, no. 01 (1989): 140–43. http://dx.doi.org/10.1055/s-0038-1646543.

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SummaryBlood coagulation in a strain of rabbits designated as Watanabe heritable hyperlipidemic (WHHL) rabbits was examined. The activities of vitamin K-dependent clotting factors, contact factors and clotting factor VIII (F VIII) and the fibrinogen level were significantly higher in WHHL rabbits than in normolipidemic rabbits (all age groups). Values for vitamin Independent clotting factor were already higher at 2 months of age. Contact factors and fibrinogen levels increased age after 5 to 8 months. F VIII increased between 5 and 8 months and then decreased. At 2 months of age, WHHL rabbits
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12

Workman, Jonathan R., Steven P. Schmidt, Duane L. Donovan, and Raymond Clarke. "The Effects of Heparin Upon Atherogenesis in the Watanabe Heritable Hyperlipidemic Rabbit." Annals of Vascular Surgery 4, no. 4 (1990): 344–49. http://dx.doi.org/10.1007/bf02000497.

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13

Clozel, J. P., H. Lengsfeld, H. Kuhn, and H. R. Baumgartner. "Decreased coronary vascular reserve in Watanabe heritable hyperlipidemic rabbits." Arteriosclerosis: An Official Journal of the American Heart Association, Inc. 8, no. 3 (1988): 310–20. http://dx.doi.org/10.1161/01.atv.8.3.310.

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14

Clubb, Fred J., Jeff L. Cerny, Dario A. Deferrari, Michelle M. Butler-Aucoin, James T. Willerson, and L. Maximilian Buja. "Development of atherosclerotic plaque with endothelial disruption in Watanabe heritable hyperlipidemic rabbit aortas." Cardiovascular Pathology 10, no. 1 (2001): 1–11. http://dx.doi.org/10.1016/s1054-8807(00)00054-5.

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15

Janiak, Philip, Nicole Villeneuve, Aline Pillon, et al. "Non-Hypertensive Deoxycorticosterone-Salt Treatment Accelerates Atherosclerosis Progression in Watanabe Heritable Hyperlipidemic Rabbit." Journal of Vascular Research 31, no. 6 (1994): 347–58. http://dx.doi.org/10.1159/000159063.

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16

Tranchart, Hadrien, Martin Gaillard, Papa Saloum Diop, Sylvie Goulinet, Panagiotis Lainas, and Ibrahim Dagher. "Transplantation of genetically modified hepatocytes after liver preconditioning in Watanabe heritable hyperlipidemic rabbit." Journal of Surgical Research 224 (April 2018): 23–32. http://dx.doi.org/10.1016/j.jss.2017.11.060.

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17

Wilson, J. M., D. E. Johnston, D. M. Jefferson, and R. C. Mulligan. "Correction of the genetic defect in hepatocytes from the Watanabe heritable hyperlipidemic rabbit." Proceedings of the National Academy of Sciences 85, no. 12 (1988): 4421–25. http://dx.doi.org/10.1073/pnas.85.12.4421.

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18

McCabe, Philip M., Julie A. Gonzales, Julia Zaias, et al. "Social Environment Influences the Progression of Atherosclerosis in the Watanabe Heritable Hyperlipidemic Rabbit." Circulation 105, no. 3 (2002): 354–59. http://dx.doi.org/10.1161/hc0302.102144.

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19

Li, Shen, Yan-Ning Wang, Manabu Niimi, et al. "Angiotensin II Destabilizes Coronary Plaques in Watanabe Heritable Hyperlipidemic Rabbits." Arteriosclerosis, Thrombosis, and Vascular Biology 36, no. 5 (2016): 810–16. http://dx.doi.org/10.1161/atvbaha.115.306871.

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20

Ishikawa, Kazunobu, Daisuke Sugawara, Jun Goto, et al. "Heme Oxygenase-1 Inhibits Atherogenesis in Watanabe Heritable Hyperlipidemic Rabbits." Circulation 104, no. 15 (2001): 1831–36. http://dx.doi.org/10.1161/hc3901.095897.

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21

Shimada, Kazuhiro, Katsuya Yoshida, Hiroyuki Tadokoro, et al. "Adenosine-Induced Coronary Flow Reserve in Watanabe Heritable Hyperlipidemic Rabbits." Japanese Circulation Journal 64, no. 12 (2000): 971–76. http://dx.doi.org/10.1253/jcj.64.971.

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22

Ikeda, Mitsunori, Hajime Kodama, and Nozomi Nohara. "Process of Foam Cell Formation in Diet-induced Hypercholesterolemic Rabbit and the Watanabe Heritable Hyperlipidemic Rabbit." Journal of Dermatology 14, no. 4 (1987): 305–12. http://dx.doi.org/10.1111/j.1346-8138.1987.tb03583.x.

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23

Koike, Tomonari, Jingyan Liang, Xiaofei Wang, et al. "Overexpression of Lipoprotein Lipase in Transgenic Watanabe Heritable Hyperlipidemic Rabbits Improves Hyperlipidemia and Obesity." Journal of Biological Chemistry 279, no. 9 (2003): 7521–29. http://dx.doi.org/10.1074/jbc.m311514200.

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24

Orfanos, Stylianos E., James B. Parkerson, Xilin Chen, et al. "Reduced lung endothelial angiotensin-converting enzyme activity in Watanabe hyperlipidemic rabbits in vivo." American Journal of Physiology-Lung Cellular and Molecular Physiology 278, no. 6 (2000): L1280—L1288. http://dx.doi.org/10.1152/ajplung.2000.278.6.l1280.

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We investigated pulmonary endothelial function in vivo in 12- to 18-mo-old male Watanabe heritable hyperlipidemic (WHHL; n = 7) and age- and sex-matched New Zealand White ( n = 8) rabbits. The animals were anesthetized and artificially ventilated, and the chest was opened and put in total heart bypass. The single-pass transpulmonary utilizations of the angiotensin-converting enzyme (ACE) substrate [3H]benzoyl-Phe-Ala-Pro (BPAP) and the 5′-nucleotidase (NCT) substrate [14C]AMP were estimated, and the first-order reaction parameter A max/ K m, where A max is the product of enzyme mass and the ca
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25

TSUKITANI, Manabu, Ryozo OKAMOTO, Yuichi ISHIKAWA, et al. "Effect of Hypoxia on Lipid Accumulation in Cultured Fibroblasts from Normal Rabbit and Watanabe Heritable Hyperlipidemic Rabbit." Journal of Clinical Biochemistry and Nutrition 2, no. 3 (1987): 279–86. http://dx.doi.org/10.3164/jcbn.2.279.

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26

Ishii, K., T. Kita, M. Yokode, et al. "Characterization of very low density lipoprotein from Watanabe heritable hyperlipidemic rabbits." Journal of Lipid Research 30, no. 1 (1989): 1–7. http://dx.doi.org/10.1016/s0022-2275(20)38393-0.

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27

Kobayashi, H., H. Suzuki, F. Sato, Y. Yonemitsu, Y. Nakashima, and K. Seuishi. "2P-0552 Pitavastatin induces plaque stabilization in Watanabe heritable hyperlipidemic rabbits." Atherosclerosis Supplements 4, no. 2 (2003): 160–61. http://dx.doi.org/10.1016/s1567-5688(03)90691-x.

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28

AMOROSA, Louis F., S. Jamie ROZOVSKI, Radha ANANTHAKRISHNAN, et al. "Effects of Pravastatin on Cholesterol Metabolism in Watanabe Heritable Hyperlipidemic Rabbits." Japanese Heart Journal 33, no. 4 (1992): 451–63. http://dx.doi.org/10.1536/ihj.33.451.

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29

Suzuki, Hideo, Hideyuki Kobayashi, Fumiyasu Sato, Yoshikazu Yonemitsu, Yutaka Nakashima, and Katsuo Sueishi. "Plaque-Stabilizing Effect of Pitavastatin in Watanabe Heritable Hyperlipidemic(WHHL) Rabbits." Journal of Atherosclerosis and Thrombosis 10, no. 2 (2003): 109–16. http://dx.doi.org/10.5551/jat.10.109.

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30

Szeto, Angela, Maria A. Rossetti, Armando J. Mendez, et al. "Oxytocin administration attenuates atherosclerosis and inflammation in Watanabe Heritable Hyperlipidemic rabbits." Psychoneuroendocrinology 38, no. 5 (2013): 685–93. http://dx.doi.org/10.1016/j.psyneuen.2012.08.009.

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31

Murakami, Shigeru, Yukiko Kondo, Takanobu Sakurai, Hideaki Kitajima, and Takatoshi Nagate. "Taurine suppresses development of atherosclerosis in Watanabe heritable hyperlipidemic (WHHL) rabbits." Atherosclerosis 163, no. 1 (2002): 79–87. http://dx.doi.org/10.1016/s0021-9150(01)00764-x.

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32

Oshima, Reiko, Toshiko Ikeda, Kazuo Watanabe, Hiroshige Itakura, and Nobutoshi Sugiyama. "Probucol treatment attenuates the aortic atherosclerosis in Watanabe heritable hyperlipidemic rabbits." Atherosclerosis 137, no. 1 (1998): 13–22. http://dx.doi.org/10.1016/s0021-9150(97)00243-8.

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33

RAGAZZI, E., A. CHINELLATO, L. PANDOLFO, et al. "Endothelial Nucleotide-Mediated Aorta Relaxation in Aged Watanabe Heritable Hyperlipidemic Rabbits." Journal of Cardiovascular Pharmacology 26, no. 1 (1995): 119–26. http://dx.doi.org/10.1097/00005344-199507000-00019.

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34

Haberland, M., D. Fong, and L. Cheng. "Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits." Science 241, no. 4862 (1988): 215–18. http://dx.doi.org/10.1126/science.2455346.

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35

Hussain, M. Mahmood, Thomas L. Innerarity, Walter J. Brecht, and Robert W. Mahley. "Chylomicron Metabolism in Normal, Cholesterol-fed, and Watanabe Heritable Hyperlipidemic Rabbits." Journal of Biological Chemistry 270, no. 15 (1995): 8578–87. http://dx.doi.org/10.1074/jbc.270.15.8578.

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36

Kitajima, Shuji, Yingji Jin, Tomonari Koike, et al. "Lp(a) enhances coronary atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits." Atherosclerosis 193, no. 2 (2007): 269–76. http://dx.doi.org/10.1016/j.atherosclerosis.2006.08.056.

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37

Gonzales, Julie A., Angela Szeto, Armando J. Mendez, et al. "Effect of Behavioral Interventions on Insulin Sensitivity and Atherosclerosis in the Watanabe Heritable Hyperlipidemic Rabbit." Psychosomatic Medicine 67, no. 2 (2005): 172–78. http://dx.doi.org/10.1097/01.psy.0000155674.95497.ab.

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38

Rall, C. J., J. M. Hoeg, R. E. Gregg, et al. "Enhanced apolipoprotein E production with normal hepatic mRNA levels in the Watanabe heritable hyperlipidemic rabbit." Arteriosclerosis: An Official Journal of the American Heart Association, Inc. 8, no. 6 (1988): 804–9. http://dx.doi.org/10.1161/01.atv.8.6.804.

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39

Shiomi, Masashi, and Takashi Ito. "The Watanabe heritable hyperlipidemic (WHHL) rabbit, its characteristics and history of development: A tribute to the late Dr. Yoshio Watanabe." Atherosclerosis 207, no. 1 (2009): 1–7. http://dx.doi.org/10.1016/j.atherosclerosis.2009.03.024.

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40

Yamada, N., I. Inoue, M. Kawamura, et al. "Apolipoprotein E prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits." Journal of Clinical Investigation 89, no. 2 (1992): 706–11. http://dx.doi.org/10.1172/jci115639.

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41

Gross, P. L., M. L. Rand, D. V. Barrow, and M. A. Packham. "Platelet function in Watanabe heritable hyperlipidemic rabbits. Decreased sensitivity to thromboxane A2." Arteriosclerosis and Thrombosis: A Journal of Vascular Biology 11, no. 3 (1991): 610–16. http://dx.doi.org/10.1161/01.atv.11.3.610.

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42

Sohma, Y., H. Sasano, R. Shiga, et al. "Accumulation of plasma cells in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits." Proceedings of the National Academy of Sciences 92, no. 11 (1995): 4937–41. http://dx.doi.org/10.1073/pnas.92.11.4937.

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43

Kano, M., J. Koizumi, A. Jadhav, and G. R. Thompson. "Plasma exchange and low density lipoprotein apheresis in Watanabe heritable hyperlipidemic rabbits." Arteriosclerosis: An Official Journal of the American Heart Association, Inc. 7, no. 3 (1987): 256–61. http://dx.doi.org/10.1161/01.atv.7.3.256.

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44

SUZUMURA, Kuniharu, Emiko KASAHARA, Yi WANG, Kuang-Chang CHIEN, and Masayasu INOUE. "Decreased Turnovers of Glutathione and Ascorbic Acid in Watanabe Heritable Hyperlipidemic Rabbits." Journal of Nutritional Science and Vitaminology 46, no. 4 (2000): 205–9. http://dx.doi.org/10.3177/jnsv.46.205.

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45

KOIKE, T., J. LIANG, X. WANG, et al. "Enhanced aortic atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits expressing lipoprotein lipase." Cardiovascular Research 65, no. 2 (2005): 524–34. http://dx.doi.org/10.1016/j.cardiores.2004.10.022.

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46

Allain, P., N. Krari, D. Chaleil, Y. Balanant, F. Bled, and M. Girault. "The distribution of elements in the tissues of Watanabe Heritable Hyperlipidemic rabbits." Biological Trace Element Research 19, no. 3 (1989): 153–60. http://dx.doi.org/10.1007/bf02924292.

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47

Atkinson, James B., Richard L. Hoover, Karen K. Berry, and Larry L. Swift. "Cholesterol-fed heterozygous Watanabe heritable hyperlipidemic rabbits: a new model for atherosclerosis." Atherosclerosis 78, no. 2-3 (1989): 123–36. http://dx.doi.org/10.1016/0021-9150(89)90216-5.

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48

Kobayashi, Tsutomu, Takashi Ito, and Masashi Shiomi. "Roles of the WHHL Rabbit in Translational Research on Hypercholesterolemia and Cardiovascular Diseases." Journal of Biomedicine and Biotechnology 2011 (2011): 1–10. http://dx.doi.org/10.1155/2011/406473.

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Conquering cardiovascular diseases is one of the most important problems in human health. To overcome cardiovascular diseases, animal models have played important roles. Although the prevalence of genetically modified animals, particularly mice and rats, has contributed greatly to biomedical research, not all human diseases can be investigated in this way. In the study of cardiovascular diseases, mice and rats are inappropriate because of marked differences in lipoprotein metabolism, pathophysiological findings of atherosclerosis, and cardiac function. On the other hand, since lipoprotein meta
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49

Hoeg, Jeffrey M., Lynn Loriaux, Richard E. Gregg, William R. Green, and H. Bryan Brewer. "Impaired adrenal reserve in the Watanabe heritable hyperlipidemic rabbit: Implications for LDL-receptor function in steroidogenesis." Metabolism 34, no. 2 (1985): 194–97. http://dx.doi.org/10.1016/0026-0495(85)90132-5.

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50

Ishikawa, Yuichi, Naoya Watanabe, Ryozo Okamoto, Yoshio Watanabe, and Hisashi Fukuzaki. "Nifedipine-suppressed atherosclerosis in cholesterol-fed rabbits but not in Watanabe heritable hyperlipidemic rabbits." Atherosclerosis 64, no. 1 (1987): 79–80. http://dx.doi.org/10.1016/0021-9150(87)90058-x.

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