Log in

Relevant bibliographies by topics / Waters Acquity C18 / Journal articles

To see the other types of publications on this topic, follow the link: Waters Acquity C18.

Journal articles on the topic 'Waters Acquity C18'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Waters Acquity C18.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Lavarello, Chiara, Sebastiano Barco, Martina Bartolucci, et al. "Development of an Accurate Mass Retention Time Database for Untargeted Metabolomic Analysis and Its Application to Plasma and Urine Pediatric Samples." Molecules 26, no. 14 (2021): 4256. http://dx.doi.org/10.3390/molecules26144256.

Full text

Abstract:

Liquid-chromatography coupled to high resolution mass spectrometry (LC-HRMS) is currently the method of choice for untargeted metabolomic analysis. The availability of established protocols to achieve a high confidence identification of metabolites is crucial. The aim of this work is to describe the workflow that we have applied to build an Accurate Mass Retention Time (AMRT) database using a commercial metabolite library of standards. LC-HRMS analysis was carried out using a Vanquish Horizon UHPLC system coupled to a Q-Exactive Plus Hybrid Quadrupole-Orbitrap Mass Spectrometer (Thermo Fisher

APA, Harvard, Vancouver, ISO, and other styles

2

Li, Yu, Qian Zhao, Pei Hu, and Ji Jiang. "CX1003 quantification by ultra-performance LC–MS/MS in human plasma and its application to a pharmacokinetic study in solid tumor patients." Bioanalysis 11, no. 16 (2019): 1483–93. http://dx.doi.org/10.4155/bio-2019-0096.

Full text

Abstract:

Aim: CX1003 is a novel multitargeted receptor tyrosine kinase inhibitor targeting cancer patients with relapsed or metastatic malignant solid tumors. The study aimed to develop a robust and rapid assay approach to quantify CX1003 in human plasma. Methodology & results: Samples of plasma were purified by SPE where the diluted eluates were then separated by a Waters Acquity CSH C18 column and thereafter detected using positive electrospray ionization via an ultra performance LC–MS/MS. Conclusion: The method to quantify CX1003 in human plasma was first exploited and validated with good sensit

APA, Harvard, Vancouver, ISO, and other styles

3

Seo, Chang-Seob, and Hyeun-Kyoo Shin. "Simultaneous Determination of 12 Marker Components in Yeonkyopaedok-san Using HPLC–PDA and LC–MS/MS." Applied Sciences 10, no. 5 (2020): 1713. http://dx.doi.org/10.3390/app10051713.

Full text

Abstract:

Yeonkyopaedok-san is a traditional Korean medicine used in the early treatment of boils. In the present study, its 12 marker components for quality control were determined using high-performance liquid chromatography (HPLC) with photodiode array detection and ultra-performance liquid chromatography–mass spectrometry with tandem mass spectrometry (UPLC–MS/MS). The investigated 12 marker components of Yeonkyopaedok-san were as follows: 3-caffeoylquinic acid, cimifugin 7-glucoside, liquiritin apioside, ferulic acid, narirutin, 5-O-methylvisammioside, naringin, neohesperidin, oxypeucedanin hydrate

APA, Harvard, Vancouver, ISO, and other styles

4

Lv, Dai Zhu, Zhu Zhu, Hong Qiu Yuan, and Jin Hui Luo. "Development and Validation of a Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) Method for the Determination of Dimethomorph and Tebuconazole Residue in Soil." Applied Mechanics and Materials 522-524 (February 2014): 132–35. http://dx.doi.org/10.4028/www.scientific.net/amm.522-524.132.

Full text

Abstract:

A liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method for the simultaneous quantification and identification of dimethomorph and tebuconazole in soil has been developed and validated. The samples were pre-concentrated and purified using QuEChERS method extraction,which provided satisfactory results. The separation was performed on a Waters ACQUITY UPLC C18 column with a linear gradient of acetonitrile - water containing 5 mM ammonium acetate. The optimised method offered a good linear correlation (r2> 0.99), excellent precision (RSD < 4.0%) and preferable recovery (from 82

APA, Harvard, Vancouver, ISO, and other styles

5

Patel, A. J., N. K. Patel, A. J. Vyas, A. B. Patel, and A. I. Patel. "RP-UPLC Stability Indicating Assay Method for Simultaneous Estimation of Dextromethorphan Hydrobromide and Chlorpheniramine Maleate in Tablet Dosage Form." Asian Journal of Organic & Medicinal Chemistry 5, no. 3 (2020): 192–96. http://dx.doi.org/10.14233/ajomc.2020.ajomc-p269.

Full text

Abstract:

RP-UPLC method was developed and validated for the determination of chlorpheniramine maleate and dextromethorphan hydrobromide in tablet dosage form. Reverse phase waters acquity UPLC BEH C18 (50 mm × 2.1 mm, 1.7 μm) column using isocratic mobile phase of 0.5 mL 0.1% TFA (trifluroacetic acid) in H2O:CH3CN (70:30 %v/v). The flow rate was 0.2 mL/min and 252 nm wavelength use for detection on PDA detector. The retention time of chlorpheniramine maleate was 1.2 min and 2.2 min for dextromethorphan hydrobromide. Chlorpheniramine maleate and dextromethorphan hydrobromide was subjected to stress cond

APA, Harvard, Vancouver, ISO, and other styles

6

Yu, Ying, Jing Zhang, Bing Shao, Yongning Wu, Hejun Duan, and Hongtao Liu. "Development of a Simple Liquid Chromatography-Tandem Mass Spectrometry Method for Multiresidue Determination of Antifungal Drugs in Chicken Tissues." Journal of AOAC INTERNATIONAL 94, no. 5 (2011): 1650–58. http://dx.doi.org/10.5740/jaoacint.10-244.

Full text

Abstract:

Abstract A method involving LC coupled with MS/MS (LC/MS/MS) was designed for simultaneous quantification of 10 antifungal drugs (voriconazole, griseofulvin, clotrimazole, bifonazole, econazole, ketoconazole, itraconazole, miconazole, terconazole, and fluconazole) in the liver and muscles of chickens. Homogenized tissue samples were extracted with acetonitrile and subsequently underwent freezing-delipidation. A Waters Acquity Ultra Performance LC BEH C18 column was used to separate the analytes, coupled with MS/MS using an electrospray ionization source. The accuracy of the method was confirme

APA, Harvard, Vancouver, ISO, and other styles

7

Nathi, Rathnakar, and Sankar D.G. "SIMULTANEOUS DETERMINATION OF BIOACTIVE CONSTITUENTS IN GARCINIA MORELLA USING UPLC-Q-TOF-MS." Indian Drugs 59, no. 03 (2022): 41–46. http://dx.doi.org/10.53879/id.59.03.12170.

Full text

Abstract:

A simple, precise and robust UPLC-Q-TOF-MS method was developed for the quantification of four marker compounds, namely citric acid derivative, iso garcinol, garcinol and garcimultiflorone-A in Garcinia morella, in order to study the fragmentation pathways of four marker compounds. The developed method was validated according to ICH guidelines in terms of linearity, LOD and LOQ, precision and accuracy. Optimized chromatographic conditions were Waters Acquity BEH C18 (100 X 2.1mm, 1.9 m) column, flow rate of 0.6 mL min-1, 8.0 minutes run time and mobile phase being 0.1 % formic acid in water /

APA, Harvard, Vancouver, ISO, and other styles

8

Harahap, Yahdiana, and Innet Maysyarah. "ANALYTICAL VALIDATION OF CLOPIDOGREL IN HUMAN PLASMA THROUGH ULTRAHIGHPERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY." International Journal of Applied Pharmaceutics 9 (October 30, 2017): 163. http://dx.doi.org/10.22159/ijap.2017.v9s1.79_86.

Full text

Abstract:

Objective: This study developed a sensitive, selective, and valid method for analyzing clopidogrel in human plasma using liquid chromatographytandemmass spectrometry (LC-MS/MS).Methods: The chromatography separation was performed on the waters ACQUITY UPLC Class BEH C18 1.7 μm (2.1 × 100 mm) column, consisting of0.1% formic acid in water and 0.1% formic acid in acetonitrile (30-70) as the mobile phase, and an isocratic elution with a flow rate of 0.2 mL/minutes.The mass detection was performed using a Waters Xevo TQD equipped with positive electrospray ionization in the multiple reaction monit

APA, Harvard, Vancouver, ISO, and other styles

9

Seo, Chang-Seob, and Hyeun-Kyoo Shin. "Development of a Reverse-Phase High-Performance Liquid Chromatography and Liquid Chromatography Tandem Mass Spectrometry Methods for Quality Control of Daegunjoong-Tang." Applied Sciences 11, no. 8 (2021): 3437. http://dx.doi.org/10.3390/app11083437.

Full text

Abstract:

Daegunjoong-tang (DGJT) is an oriental medicine consisting of four medicinal herbs (Zingiber officinale Rosc., Panax ginseng C.A.Mey., Oryza sativa L., and Zanthoxylum schinifolium Sieb. et Zucc.) that is used to treat intestinal- and cancer-related diseases. In this study, a protocol for quality control of DGJT based on reverse-phase high-performance liquid chromatography (HPLC) and liquid chromatography tandem mass spectrometry (LC–MS/MS) analysis were developed. In HPLC analysis, the marker analytes (hyperoside, quercitrin, ginsenoside Rg1, and 6-gingerol) were separated, verified, and quan

APA, Harvard, Vancouver, ISO, and other styles

10

Seo, Chang-Seob, and Kwang-Hoon Song. "Phytochemical Characterization for Quality Control of Phyllostachys pubescens Leaves Using High-Performance Liquid Chromatography Coupled with Diode Array Detector and Tandem Mass Detector." Plants 11, no. 1 (2021): 50. http://dx.doi.org/10.3390/plants11010050.

Full text

Abstract:

Phyllostachys pubescens leaves are cultivated in a number of Asian countries and have been used for antipyretic and diuretic effects since ancient times, especially in Korea. The purpose of this study was to develop and validate of analytical method for quality control of P. pubescens leaves using high-performance liquid chromatography with diode array detector (HPLC–DAD) and liquid chromatography with tandem mass spectrometry (LC–MS/MS) detection. HPLC–DAD analysis was conducted with a Gemini C18 column, and distilled water–acetonitrile (both with 0.1% (v/v) formic acid) mobile-phase system.

APA, Harvard, Vancouver, ISO, and other styles

11

Al-Tannak, Naser F., Nada A. Al-Hasawi, and Ladislav Novotny. "UHPLC-UV Analysis of Morin and Structurally Related Flavonoids with Potential Anticancer Activity." Current Pharmaceutical Analysis 15, no. 4 (2019): 295–304. http://dx.doi.org/10.2174/1573412914666171220154224.

Full text

Abstract:

Background: Flavonoids as secondary metabolites of plants fulfill various functions in cell protection. They are of a considerable scientific interest because of their potentially medical use due to their anticancer, chemoprotective, antimicrobial, antiallergic, anti-inflammatory and antiviral activities. </P><P> Objective: The study aimed to develop a new UHPLC-UV method for morin and 2 other structurally related flavonoids - naringenin and kaempferol as the structural similarity of huge numbers of flavonoids does not limit their various biological functions and activities. Method

APA, Harvard, Vancouver, ISO, and other styles

12

Bhosale, Dileep M., and Anna Pratima G. Nikalje. "Stability-Indicating UPLC Method for the Estimation of Nadifloxacin, Terbinafine Hydrochloride, Mometasone Furoate, Methyl Paraben, and Propyl Paraben in Topical Pharmaceutical Dosage Form." Journal of AOAC INTERNATIONAL 100, no. 5 (2017): 1407–13. http://dx.doi.org/10.5740/jaoacint.16-0254.

Full text

Abstract:

Abstract A novel and simple ultra-performance LC method was developed for the estimation of nadifloxacin (NAD), terbinafine hydrochloride (TBH), mometasone furoate (MMF), methyl paraben (MP), and propyl paraben (PP) in a topical pharmaceutical dosage formulation. The analysis was carried out on a Waters Acquity UPLC ethylene bridged hybrid C18 column (50 × 2.1 mm, 1.7 μm) with a flow rate of 0.4 mL/min ingradient mode at a wavelength of 255 nm. Elution of all components was achieved within 9 min. The retention times of MP, NAD, PP, TBH, and MMF were observedat 1.5, 2.6, 3.4, 6.0, and 6.9 min,

APA, Harvard, Vancouver, ISO, and other styles

13

Ezzeldin, Essam, Nisreen F. Abo-Talib, and Marwa H. Tammam. "UPLC-Tandem Mass Spectrometry Method for Simultaneous Determination of Fluoxetine, Risperidone, and Its Active Metabolite 9-Hydroxyrisperidone in Plasma: Application to Pharmacokinetics Study in Rats." Journal of Analytical Methods in Chemistry 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/5187084.

Full text

Abstract:

Risperidone (RIS) is used as an antipsychotic drug alone or with other drugs, like fluoxetine (FLX). A simple method was developed and validated for the determination of both RIS and its metabolite 9-hydroxyrisperidone (9-OH-RIS), FLX, and olanzapine (OLA) as an internal standard in rat’s plasma using UPLC-MS/MS. FLX, RIS, 9-OH-RIS, and OLA were purified using acetonitrile as a protein precipitating agent. Separation was performed on an ACQUITY™ “UPLC BEH™” C18 column (50 mm × 2.1 mm i.d., 1.7 μm; Waters Corp., USA). The ranges of the calibration curves were 1.0–1000.0 ng/mL for FLX and 0.2–10

APA, Harvard, Vancouver, ISO, and other styles

14

Sun, Huiting, Han Xing, Xueke Tian, Xiaojian Zhang, Jing Yang, and Peile Wang. "UPLC-MS/MS Method for Simultaneous Determination of 14 Antimicrobials in Human Plasma and Cerebrospinal Fluid: Application to Therapeutic Drug Monitoring." Journal of Analytical Methods in Chemistry 2022 (January 5, 2022): 1–7. http://dx.doi.org/10.1155/2022/7048605.

Full text

Abstract:

Pharmacokinetics/pharmacodynamics is the foundation for guiding the rational application of antibiotics in clinical practice, so it is necessary to establish quantitative methods for accurate drug concentration determination. This study aimed to develop a rapid and simple ultrahigh-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for simultaneous quantification of 14 antibiotics (amikacin, etimicin, ceftazidime, cefepime, cefoperazone, ceftriaxone, daptomycin, latamoxef, linezolid, meropenem, biapenem, ampicillin, norvancomycin, and vancomycin) in human plasma and

APA, Harvard, Vancouver, ISO, and other styles

15

Zhang, Yudong, Yue Jiang, Ya Wang, et al. "An UPLC-MS/MS Method for Routine Quantification of Insulin Degludec in Plasma." Current Pharmaceutical Analysis 16, no. 6 (2020): 792–99. http://dx.doi.org/10.2174/1573412915666190304145149.

Full text

Abstract:

Background: Chromatographic methods for determination of insulin degludec in rabbit plasma by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry were developed. Methods: Analytes were eluted from Waters ACQUITY UPLC® Peptide BEH C18 (2.1×50mm, 300Å) column with a mobile phase of water containing 0.1% formic acid (A) and acetonitrile containing 0.1% formic acid (B). Quantitation of insulin degludec was performed using 1222.06 > 641.24 m/z on Multiple- Reaction Monitoring (MRM) mode. Results: Good linearity was observed in the concentration range of 500-50000 ng/mL (r >0.99),

APA, Harvard, Vancouver, ISO, and other styles

16

Vele, Vinayak T., Kishor More, Mohan A. Chandavarkar, Shivaji Kadam, Sushil Singh, and Amol Kumbha. "Determination and Quantification of an N-nitroso-Betaxolol in the Betaxolol Hydrochloride Active Pharmaceutical Ingredient by LC-MS/MS." Der Pharma Chemica 16, no. 2 (2024): 6. https://doi.org/10.4172/0975- 413X.16.2. 257-262.

Full text

Abstract:

A Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) method was developed for the quantification of N-nitroso-betaxolol in the betaxolol hydrochloride active pharmaceutical ingredient. Chromatographic separation was achieved using a waters acquity BEH C18 column, with 0.1% formic acid in water and Methanol as mobile phase in gradient elution mode at a 0.25 ml/ min flow rate. Quantification of impurities was carried out using triple quadrupole mass detection with electrospray ionization in the multiple reaction monitoring modes. The method was validated with good linearity over the conce

APA, Harvard, Vancouver, ISO, and other styles

17

Nguyen Thi Anh Nguyet, Nguyen Kieu Quynh Trang, Nguyen Tan Phat, et al. "METHOD DEVELOPMENT FOR SIMULTANEOUS QUANTIFICATION OF NARINGIN AND MELITIDINE IN YOUNG POMELO FRUITS BY HPLC-PDA." Tạp chí Dược liệu 30, no. 3 (2025): 172–78. https://doi.org/10.63240/jmm-nimm.2025.3.131.

Full text

Abstract:

In this study, an HPLC method was developed for quantitative analysis of melitidine and naringin, which were found in young pomelo fruits. This procedure was performed on the Waters Acquity UPLC system, using a GL Sciences InertSustain C18 chromatographic column (4.6 × 250 mm; 5 µm). Mobile phase (acetonitrile - acetic acid 0.1%), flow rate of 1 mL/min, and injection volume of 10 µL, UV detection at 283 nm. The developed method met all validation requirements of ICH guidelines as follows: System suitability, specificity, and linear range of naringin (50 - 1000 µg/mL) and melitidine (25 - 500 µ

APA, Harvard, Vancouver, ISO, and other styles

18

Drapak, Iryna, Borys Zimenkovsky, Liudas Ivanauskas, et al. "HPLC method for simultaneous determination of impurities and degradation products in Cardiazol." Pharmacia 67, no. 1 (2020): 29–37. http://dx.doi.org/10.3897/pharmacia.67.e37004.

Full text

Abstract:

Aim. The aim of study was to develop a simple and accurate procedure that could be applied for the determination of impurities and degradation products in cardiazol. Materials and methods. Separation in samples was carried out with Acquity H-class UPLC system (Waters, Milford, USA) equipped with Acquity UPLC BEH C18 column (2.1 × 50 mm, 1.7 μm) (Waters, Milford, USA). Xevo TQD triple quadrupole mass spectrometer detector (Waters Millford, USA) was used to obtain MS/MS data. Mobile phase A: 0.1% solution of trifluoroacetic acid R in water R; Mobile phase B: acetonitrile R. Samples were chromato

APA, Harvard, Vancouver, ISO, and other styles

19

Drapak, Iryna, Borys Zimenkovsky, Liudas Ivanauskas, et al. "HPLC method for simultaneous determination of impurities and degradation products in Cardiazol." Pharmacia 67, no. (1) (2020): 29–37. https://doi.org/10.3897/pharmacia.67.e37004.

Full text

Abstract:

Aim. The aim of study was to develop a simple and accurate procedure that could be applied for the determination of impurities and degradation products in cardiazol. Materials and methods. Separation in samples was carried out with Acquity H-class UPLC system (Waters, Milford, USA) equipped with Acquity UPLC BEH C18 column (2.1 × 50 mm, 1.7 μm) (Waters, Milford, USA). Xevo TQD triple quadrupole mass spectrometer detector (Waters Millford, USA) was used to obtain MS/MS data. Mobile phase A: 0.1% solution of trifluoroacetic acid R in water R; Mobile phase B: acetonitrile R. Samples were chromato

APA, Harvard, Vancouver, ISO, and other styles

20

Chen, Pei, and Noella Bryden. "Determination of Yohimbine in Yohimbe Bark and Related Dietary Supplements Using UHPLC-UV/MS: Single-Laboratory Validation." Journal of AOAC INTERNATIONAL 98, no. 4 (2015): 896–901. http://dx.doi.org/10.5740/jaoacint.13-170.

Full text

Abstract:

Abstract A single-laboratory validation was performed on a practical ultra-HPLC (UHPLC)-diode array detector (DAD)/tandem MS method for determination of yohimbine in yohimbe barks and related dietary supplements. Good separation was achieved using a Waters Acquity ethylene bridged hybrid C18 column with gradient elution using 0.1% (v/v) aqueous ammonium hydroxide and 0.1% ammonium hydroxide in methanol as the mobile phases. The method can separate corynanthine from yohimbine in yohimbe bark extract, which is critical for accurate quantitation of yohimbine in yohimbe bark and related dietary su

APA, Harvard, Vancouver, ISO, and other styles

21

Meng, Li, Hui Gao, Bin Chen, et al. "Simultaneous Determination of Five Chromones of Radix Saposhnikoviae Extract in Rat Plasma by UPLC-MS/MS: Application to a Comparative Pharmacokinetic Study in Normal and Febrile Rats." Journal of Analytical Methods in Chemistry 2019 (February 26, 2019): 1–11. http://dx.doi.org/10.1155/2019/6454252.

Full text

Abstract:

A rapid and sensitive quantitative analytical method was established for the simultaneous determination of five chromones (prim-O-glucosylcimifugin, cimifugin, 4′-O-β-D-glucosyl-5-O-methylvisamminol, 5-O-methylvisammiol, and sec-o-glucosylhamaudol) in the plasma of RS-treated rats for the first time using ultra performance liquid chromatography- (UPLC-) tandem mass spectrometry. The Waters Acquity UPLC BEH C18 (50 mm × 2.1 mm, 1.7 μm) was used as the chromatographic column, 0.1% formic acid water and 0.1% formic acid acetonitrile comprised the mobile phases, and all samples were determined und

APA, Harvard, Vancouver, ISO, and other styles

22

Typlynska, Kateryna, Yuliya Kondratova, Mariana Horyn, and Liliya Logoyda. "Ultra-performance liquid chromatography-mass spectrometry methods for the determination of the residual quantities of ramipril and hydrochlorothiazide for controlling the cleaning of equipment." ScienceRise: Pharmaceutical Science, no. 4 (50) (August 30, 2024): 35–43. http://dx.doi.org/10.15587/2519-4852.2024.310759.

Full text

Abstract:

Monitoring the completeness of equipment cleaning is essential to prevent cross-contamination of medicinal products. Therefore, it is necessary to develop fast and sensitive methods for studying residual quantities of active ingredients on the surfaces of technological equipment. The aim of the work was to develop and validate analytical methods for the determination of ramipril and hydrochlorothiazide in wash waters by ultra-performance liquid chromatography–mass spectrometry method. Materials and methods. In the study, standard samples of ramipril (USP RS) and hydrochlorothiazide (USP RS), a

APA, Harvard, Vancouver, ISO, and other styles

23

D, Suchitra, and Satyanarayana Battu. "Development and Validation of Stability Indicating RP-UPLC Method for the Estimation of Pomalidomide in Bulk and Pharmaceutical Dosage Form." YMER Digital 21, no. 02 (2022): 248–63. http://dx.doi.org/10.37896/ymer21.02/25.

Full text

Abstract:

The present research work is mainly focussed on development of a novel, rapid, accurate and stability indicating UPLC method by using an advanced separation technique called Ultra Performance Liquid Chromatography, for the quantitative analysis of Pomalidomide in bulk and pharmaceutical dosage forms. This is a modified form of HPLC technique in which there is a significant increase in sensitivity, resolution and rapidity. The operation was carried out on a Waters Acquity UPLC instrument. Data acquisition and processing was done using Empower 2 software. The drug was eluted on an Acquity BEH C1

APA, Harvard, Vancouver, ISO, and other styles

24

Babu D, China, Madhusudhana Chetty C, and Mastanamma S. K. "FORCED INDICATING UPLC-DAD METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF APALUTAMIDE IN BULK AND IN PHARMACEUTICAL DOSAGE FORM." INDIAN DRUGS 58, no. 09 (2021): 73–75. http://dx.doi.org/10.53879/id.58.09.11795.

Full text

Abstract:

A new analytical method was developed for the estimation of apalutamide in bulk and its pharmaceutical formulation. The sensitive, précise and accurate method was developed by using Waters Acquity UPLC system equipped with quaternary gradient pump. The column used was Waters C18 150 X 2.1 mm X 1.7 µm and mobile phase was 0.2 % OPA buffer in water : acetonitrile in the ratio of 25:75 V/V. The buffer pH was maintained at 4.5. The fl ow rate of mobile phase was 0.5 mL min-1 and detection was at 272 nm by using PDA detector. The method was performed at ambient temperature. The retention time of th

APA, Harvard, Vancouver, ISO, and other styles

25

Favreto, Wagner Alex Jann, Ana Maria Pugens Pinto, Josélia Larger Manfio, Ivonete Hoss, Mariely Camila Pristch, and Solange Fátima Bordignon. "Development and Validation of an Ultra-Performance Liquid Chromatography/Electrospray Ionization-Tandem Mass Spectrometry Bioanalytical Method for Quantifying Clonazepam in Human Plasma." Journal of AOAC INTERNATIONAL 96, no. 4 (2013): 745–50. http://dx.doi.org/10.5740/jaoacint.11-263.

Full text

Abstract:

Abstract A sensitive, selective, and rapid ultra-performance LC (UPLC)/MS/MS method was validated for the confirmation and quantification of clonazepam in human plasma. The analyte was extracted from human plasma with diethyl ether, reaching an average recovery of 64.02 and 66.48% for clonazepam and the internal standard, respectively. The separation was performed on a Waters ACQUITY UPLC™ BEH C18 column (50 × 2.1 mm id, 1.7 μm particle size) with gradient elution at a flow rate of 0.25 mL/min using a 0.5% formic acid solution (mobile phase A) and acetonitrile–methanol–formic acid (75 + 25 + 0

APA, Harvard, Vancouver, ISO, and other styles

26

Sharma, Nitish, Surendra Singh Rao, Namala Durga Atchuta Kumar, and Annarapu Malleswara Reddy. "A Novel Validated Ultra-Performance Liquid Chromatography Method for Separation of Eszopiclone Impurities and its Degradants in Drug Products." Journal of AOAC INTERNATIONAL 96, no. 5 (2013): 981–86. http://dx.doi.org/10.5740/jaoacint.11-489.

Full text

Abstract:

Abstract A selective, specific, and sensitive ultra-performance LC (UPLC) method was developed for determination of eszopiclone and its degradation products. The chromatographic separation was performed with a Waters ACQUITY UPLC system and BEH C18 column using gradient elution with mobile phases A and B. Mobile phase A was 0.01 M phosphate buffer with 0.2% (w/v) 1-octane sulfonic acid sodium salt as an ion pair reagent, adjusted pH 2.2 with orthophosphoric acid–acetonitrile (85 + 15, v/v). Mobile phase B was pH 2.2 buffer–acetonitrile (20 + 80, v/v). UV detection was performed at 303 nm. Eszo

APA, Harvard, Vancouver, ISO, and other styles

27

Cong, Yan Li, Shen Li, Bo Chen, Hai Yan Sun, Dong Liu, and Shu Fen Cui. "UPLC-ESI-MS/MS Method for Determination of Recombinant Antihypertensive Peptide in Rat Plasma." Applied Mechanics and Materials 730 (January 2015): 254–59. http://dx.doi.org/10.4028/www.scientific.net/amm.730.254.

Full text

Abstract:

The focus of the study was to establish an UPLC-ESI-MS/MS method for the qualitative and quantitative determination of VLPVPR in rat plasma. The method was as follows: Protein impurities in the rat plasma samples were precipitated with methanol; A Waters Acquity BEH C18 column (100 mm×2.1 mm, 1.7 μm) was adopted; the column temperature was 25°C; the mobile phase consisted of methanol-water with gradient elution at the steady flow rate of 0.3 mL·min-1; the detection wavelength was 202 nm. Mass spectrometry applied selected ion monitoring mode with m/z 255 (quantitative ion) and m/z 169 (qualita

APA, Harvard, Vancouver, ISO, and other styles

28

Aldhafiri, Wafaa N., Yashpal S. Chhonker, Yuning Zhang, et al. "Assessment of Tissue Distribution and Metabolism of MP1, a Novel Pyrrolomycin, in Mice Using a Validated LC-MS/MS Method." Molecules 25, no. 24 (2020): 5898. http://dx.doi.org/10.3390/molecules25245898.

Full text

Abstract:

MP1 is a novel marinopyrrole analogue with activity in MYCN amplified neuroblastoma cell lines. A rapid, selective, and sensitive liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method was developed and validated for quantitation of MP1 in mouse plasma. Analyte separation was achieved using a Waters Acquity UPLC®BEH C18 column (1.7 µm, 100 × 2.1 mm). Mobile phase consisted of 0.1% acetic acid in water (10%) and methanol (90%) at a total flow rate of 0.25 mL/min. The mass spectrometer was operated at unit resolution in the multiple reaction monitoring (MRM) mode, using pr

APA, Harvard, Vancouver, ISO, and other styles

29

Zheng, Yanjuan, Qiushi Peng, Rui Dong, et al. "Simultaneous Determination of Methocarbamol and Paracetamol in the Presence of Three Related Substances by Ultra Performance Liquid Chromatography." Current Pharmaceutical Analysis 15, no. 5 (2019): 505–10. http://dx.doi.org/10.2174/1573412914666180702150357.

Full text

Abstract:

Introduction: A rapid, and accurate Ultra Performance Liquid Chromatography (UPLC) method was developed to simultaneously analyze Methocarbamol, Paracetamol and the related substances Materials and Methods: Waters ACQUITY UPLC® BEH Phenyl C18 column was used in conjunction with UV detection at 225nm. Gradient elution with 0.05M, pH 6 phosphate buffer and acetonitrile flow at 0.3mL /min rate were used to separate the substances. The retention times for 4-Aminopheno, Paracetamol, Guaifenesin, Methocarbamol, and 4-Chloroacetanilide were 1.319 minute, 2.224 minute, 4.467 minute, 4.769 minute and 5

APA, Harvard, Vancouver, ISO, and other styles

30

Kondratova, Yuliya, Liliya Logoyda, Yuliia Voloshko, Ahmed Abdel Megied, Dmytro Korobko, and Yuriy Soroka. "DEVELOPMENT AND VALIDATION OF HPLC-DAD METHOD FOR THE DETERMINATION OF BISOPROLOL IN TABLET DOSAGE FORMS." International Journal of Applied Pharmaceutics 9, no. 6 (2017): 54. http://dx.doi.org/10.22159/ijap.2017v9i6.21616.

Full text

Abstract:

Objective: A rapid, simple and sensitive RP-HPLC method was developed and validated for the determination of bisoprolol fumarate in bulk and pharmaceutical dosage form.Methods: Chromatographic separation was achieved within 2.5 min on ACQUITY Arc System, Waters Symmetry C18 column (3.9 mm i.d. X 150 mm, 5 μm particle sizes) using a mobile phase consisted of acetonitrile: phosphate buffer (25:75 v/v) in an isocratic mode at a flow rate of 1.4 ml/min. The pH of the mobile phase was adjusted to 7.0 with orthophosphoric acid and UV detection was set at 226 nm.Results: The retention time for bisopr

APA, Harvard, Vancouver, ISO, and other styles

31

Wang, Moli, Yanxia Gao, Xueli Liu, et al. "Determination and pharmacokinetic analysis of ticarcillin disodium–clavulanate potassium for injection in rat plasma by UPLC-ESI-MS/MS." Journal of International Medical Research 48, no. 12 (2020): 030006052096782. http://dx.doi.org/10.1177/0300060520967822.

Full text

Abstract:

Objective To establish a specific and rapid ultra-high-performance liquid chromatography–electrospray ionization–tandem mass spectrometry (UPLC-ESI-MS/MS) method for measuring ticarcillin and clavulanate levels in rat plasma. Methods A Waters ACQUITY BEH C18 column (50 mm × 2.1 mm, 1.7 μm) and SCIEX QTRAP® LC-MS/MS System were used. Analyses were conducted to optimize the chromatographic and MS conditions, and the pharmacokinetic parameters of ticarcillin and clavulanate were assessed. Results Linear relationships were observed in the ranges of 10 to 10,000 ng/mL for ticarcillin R (r2 = 0.9967

APA, Harvard, Vancouver, ISO, and other styles

32

Dailey, Rebecca, Roger Siemion, Merl Raisbeck, and Chris Jesse. "Analysis of Salazinic, Norstictic, and Usnic Acids in Xanthoparmelia chlorochroa by Ultra-Performance Liquid Chromatography/Tandem Mass Spectrometry." Journal of AOAC INTERNATIONAL 93, no. 4 (2010): 1137–42. http://dx.doi.org/10.1093/jaoac/93.4.1137.

Full text

Abstract:

Abstract The lichen species Xanthoparmelia chlorochroa is toxic when consumed by domestic sheep, cattle, and Rocky Mountain elk. Clinical signs exhibited by poisoned animals include red urine, ataxia, and muscular weakness that rapidly progresses to recumbency. Elk are unable to recover once becoming recumbent; however, most affected cattle can recover if offered suitable feed shortly following the onset of signs. At present, the pathogenesis and specific toxin(s) are unknown. As part of an effort to elucidate the proximate toxin, a method using ultra-performance LC coupled to MS/MS with negat

APA, Harvard, Vancouver, ISO, and other styles

33

Seo, Chang-Seob, and Hyeun-Kyoo Shin. "Ultra-Performance Liquid Chromatography with Tandem Mass Spectrometry for Simultaneous Analysis of 22 Analytes of Oncheong-Eum, a Traditional Korean Herbal Formula." Processes 11, no. 10 (2023): 2906. http://dx.doi.org/10.3390/pr11102906.

Full text

Abstract:

Oncheong-eum (OCE) is a traditional Korean herbal formula comprising eight medicinal herbs for treating skin disorders, including eczema and skin rashes. Here, we sought to simultaneously analyze 22 analytes of OCE using ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS). All analytes were separated on a Waters Acquity UPLC BEH C18 column (2.1 mm × 100 mm, 1.7 μm) maintained at 45 °C by gradient elution with a mobile phase of 0.1% (v/v) aqueous formic acid–acetonitrile. By applying a multiple reaction monitoring method, we rapidly determined the various analytes simu

APA, Harvard, Vancouver, ISO, and other styles

34

Arlinda, Dona, Intan Sari Oktoberia, and Muhammad Karyana. "Validation of a Liquid Chromatography/Tandem Mass Spectrometry Assay for the Quantification of Plasma Dihydroartemisinin." Molecular and Cellular Biomedical Sciences 5, no. 3 (2021): 127. http://dx.doi.org/10.21705/mcbs.v5i3.194.

Full text

Abstract:

Background: Insufficient plasma level of dihydroartemisinin (DHA) can select resistance and will further hinder malaria elimination program. We investigated clinical applicability of a validated liquid chromatography/tandem mass spectrometry (LC-MS/MS) assay to quantify plasma concentration of DHA in healthy subjects from a single oral administration of fixed dose combination of Dihydroartemisinin-Piperaquine.Materials and Methods: Micro-elution solid-phase extraction in a 96-well plate format was used to prepare the samples. DHA separation happened in Acquity UPLCTM BEH C18 column (50 × 2.1 m

APA, Harvard, Vancouver, ISO, and other styles

35

Palonko, Roman, Oleksii Arnauta, Victoriia Prys-Kadenko, Oleh Smirnov, and Liliia Kalachniuk. "Combined preparation based on chelating magnesium by phosphorylated casein. Characteristics of its syntesis." ScienceRise: Biological Science, no. 1(26) (March 31, 2021): 27–31. http://dx.doi.org/10.15587/2519-8025.2021.228758.

Full text

Abstract:

The article is devoted to the development and synthesis of a new drug for use in animal husbandry and veterinary medicine as an immunostimulatory and adaptogenic agent. The basis of the new drug is a combination of magnesium, phosphorus, and casein of cow's milk. Given the important scientific and practical importance for veterinary medicine of innovative drugs that would have pronounced immunostimulatory and adaptogenic properties, the aim of our research is to develop a method of obtaining a new drug with an original composition and further studies of its effectiveness and safety.&#x0D

APA, Harvard, Vancouver, ISO, and other styles

36

Roman, Palonko, Arnauta Oleksii, Prys-Kadenko Victoriia, Smirnov Oleh, and Kalachniuk Liliia. "Combined preparation based on chelating magnesium by phosphorylated casein. Characteristics of its syntesis." Eastern-European Journal of Enterprise Technologies, no. 1 (26) (March 31, 2021): 27–31. https://doi.org/10.15587/2519-8025.2021.228758.

Full text

Abstract:

The article is devoted to the development and synthesis of a new drug for use in animal husbandry and veterinary medicine as an immunostimulatory and adaptogenic agent. The basis of the new drug is a combination of magnesium, phosphorus, and casein of cow's milk. Given the important scientific and practical importance for veterinary medicine of innovative drugs that would have pronounced immunostimulatory and adaptogenic properties, <strong>the aim of our research</strong> is to develop a method of obtaining a new drug with an original composition and further studies of its effec

APA, Harvard, Vancouver, ISO, and other styles

37

Ayyil, Hafis Jamal, Kathirvel Singaram, and Raja Rajeswari Katta. "UPLC Method Validation for Bioanalysis of Gemcitabine on Rat PK Study Using VAMS Methodology (Volumetric Absorptive Microsampling)." Der Pharma Chemica 15, no. 3 (2023): 14. https://doi.org/10.5281/zenodo.13318868.

Full text

Abstract:

Volumetric absorptive microsampling (VAMS) is a simple intuitive technique for collecting and quantitative analysis of dried blood samples. It enables the collection of an accurate blood volume regardless of blood hematocrit. A bioanalytical method for the determination of gemcitabine in dried blood supported on VAMS samplers has been validated and used to support a pharmacokinetic study in rat. The calculated PK parameters were comparable to those obtained from blood–water (1:1, v/v) samples. VAMS is demonstrated to be a robust method that simplifies both the blood sample collection and

APA, Harvard, Vancouver, ISO, and other styles

38

Hafis, Jamal Ayyil, Singaram Kathirvel, and Raja Rajeswari Katta. "UPLC Method Validation for Bioanalysis of Gemcitabine on Rat PK Study Using VAMS Methodology (Volumetric Absorptive Microsampling)." DER PHARMA CHEMICA 15, no. 3 (2023): 14. https://doi.org/10.4172/0975-413X.15.3.38-51.

Full text

Abstract:

Volumetric absorptive microsampling (VAMS) is a simple intuitive technique for collecting and quantitative analysis of dried blood samples. It enables the collection of an accurate blood volume regardless of blood hematocrit. A bioanalytical method for the determination of gemcitabine in dried blood supported on VAMS samplers has been validated and used to support a pharmacokinetic study in rat. The calculated PK parameters were comparable to those obtained from blood–water (1:1, v/v) samples. VAMS is demonstrated to be a robust method that simplifies both the blood sample collection and

APA, Harvard, Vancouver, ISO, and other styles

39

Hafis, Jamal Ayyil, Kathirvel Singaram, and Raja Rajeswari Katta. "UPLC Method Validation for Bioanalysis of Gemcitabine on Rat PK Study Using VAMS Methodology (Volumetric Absorptive Microsampling)." DER PHARMA CHEMICA 15, no. 3 (2023): 14. https://doi.org/10.4172/0975-413X.15.3.

Full text

Abstract:

Volumetric absorptive microsampling (VAMS) is a simple intuitive technique for collecting and quantitative analysis of dried blood samples. It enables the collection of an accurate blood volume regardless of blood hematocrit. A bioanalytical method for the determination of gemcitabine in dried blood supported on VAMS samplers has been validated and used to support a pharmacokinetic study in rat. The calculated PK parameters were comparable to those obtained from blood–water (1:1, v/v) samples. VAMS is demonstrated to be a robust method that simplifies both the blood sample collection and

APA, Harvard, Vancouver, ISO, and other styles

40

Seo, Chang-Seob, and Hyeun-Kyoo Shin. "Liquid Chromatography Tandem Mass Spectrometry for the Simultaneous Quantification of Eleven Phytochemical Constituents in Traditional Korean Medicine, Sogunjung Decoction." Processes 9, no. 1 (2021): 153. http://dx.doi.org/10.3390/pr9010153.

Full text

Abstract:

The Sogunjung decoction (SGJD) is a traditional herbal formula that has been used to treat constipation and improve the constitution of infirm children in Korea. In this study, simultaneous quantification of gallic acid (1), magnoflorine (2), albiflorin (3), paeoniflorin (4), liquiritin apioside (5), liquiritin (6), liquiritigenin (7), coumarin (8), cinnamaldehyde (9), benzoylpaeoniflorin (10), and glycyrrhizin (11) was conducted using fast and sensitive liquid chromatography–tandem mass spectrometry (LC–MS) multiple-reaction monitoring to develop a quality-control protocol for the SGJD. A Wat

APA, Harvard, Vancouver, ISO, and other styles

41

Prameela, Rani A., S. Madhavi, Rao B. Tirumaleswara, and Sudheer Reddy CH. "STABILITY INDICATING UPLC METHOD FOR ESTIMATION OF METFORMIN HYDROCHLORIDE AND NATEGLINIDE SIMULTANEOUSLY IN THE PRESENCE OF STRESS DEGRADATION PRODUCTS." INDIAN DRUGS 57, no. 05 (2020): 56–64. http://dx.doi.org/10.53879/id.57.05.11332.

Full text

Abstract:

A novel Ultra Performance Liquid Chromatography (UPLC) method was developed and validated for the simultaneous determination of antidiabetic drugs metformin hydrochloride and nateglinide. The method was developed using a Waters ACQUITY UPLC SB C18 (100 × 2.1 mm, 1.8 μm) column. The mobile phase consisting of 0.01 % potassium dihydrogen phosphate buffer (pH 5.8): acetonitrile (50: 50 V/V) was used throughout the analysis. The flow rate was 0.3 mL/min, the injection volume was 1.0 μL, column temperature was 30 0C, run time 3 min and detection was carried at 238 nm using a TUV detector. The reten

APA, Harvard, Vancouver, ISO, and other styles

42

Dutta Tejaswi, Juluri Krishna, and Govinda Rajan R. "REVERSE-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION AND FORCED DEGRADATION STUDIES OF EMTRICITABINE, RILPIVIRINE, AND TENOFOVIR ALAFENAMIDE IN SOLID DOSAGE FORM." Asian Journal of Pharmaceutical and Clinical Research 12, no. 1 (2019): 112. http://dx.doi.org/10.22159/ajpcr.2018.v12i1.28765.

Full text

Abstract:

Objective: A stability indicating reverse-phase high-performance liquid chromatography (RP-HPLC) method was developed and validated for the estimation of emtricitabine (EMT), rilpivirine (RIL), and tenofovir alafenamide (TAF) in combined dosage forms and its API.Methods: Chromatographic separation was achieved on Waters ACQUITY RP-HPLC with PDA detector having Zodiac C18 Column (250×4.6×5μ) using mobile phase mixture of phosphate buffer: acetonitrile in the ratio of 40:60 v/v at 262 nm.Results: The assay was performed with tablets, and the % assay was found to be 100.104 for EMT, 99.74 for RIL

APA, Harvard, Vancouver, ISO, and other styles

43

Dutta Tejaswi, Juluri Krishna, and Govinda Rajan R. "REVERSE-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION AND FORCED DEGRADATION STUDIES OF EMTRICITABINE, RILPIVIRINE, AND TENOFOVIR ALAFENAMIDE IN SOLID DOSAGE FORM." Asian Journal of Pharmaceutical and Clinical Research 12, no. 1 (2019): 112. http://dx.doi.org/10.22159/ajpcr.2019.v12i1.28765.

Full text

Abstract:

Objective: A stability indicating reverse-phase high-performance liquid chromatography (RP-HPLC) method was developed and validated for the estimation of emtricitabine (EMT), rilpivirine (RIL), and tenofovir alafenamide (TAF) in combined dosage forms and its API.Methods: Chromatographic separation was achieved on Waters ACQUITY RP-HPLC with PDA detector having Zodiac C18 Column (250×4.6×5μ) using mobile phase mixture of phosphate buffer: acetonitrile in the ratio of 40:60 v/v at 262 nm.Results: The assay was performed with tablets, and the % assay was found to be 100.104 for EMT, 99.74 for RIL

APA, Harvard, Vancouver, ISO, and other styles

44

Yang, Yuedong, Hao Zhi, Baofei Yan, et al. "Comparison Study on the Contents of Eight Flavonoids in three Different Processed Products of Scutellariae Radix using Ultra-high Performance Liquid Chromatography Coupled With Triple-Quadrupole Mass Spectrometry." Current Pharmaceutical Analysis 16, no. 6 (2020): 690–97. http://dx.doi.org/10.2174/1573412915666190206124150.

Full text

Abstract:

Background: The simultaneous determination of multiple components in a sample is an important factor in the quality control of traditional Chinese medicines and can give an indication of potential clinical applications. Introduction: A rapid and sensitive method has been introduced for the simultaneous quantitative analysis of eight bioactive flavonoid constituents from Scutellariae Radix using ultra-high performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry. Methods: The separation was performed on a Waters Acquity UPLC C18 column (2.1 mm×100 mm, 1.7 μm), u

APA, Harvard, Vancouver, ISO, and other styles

45

Mishra, Tulsidas, and Pranav S. Shrivastav. "Validation of Simultaneous Quantitative Method of HIV Protease Inhibitors Atazanavir, Darunavir and Ritonavir in Human Plasma by UPLC-MS/MS." Scientific World Journal 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/482693.

Full text

Abstract:

Objectives. HIV protease inhibitors are used in the treatment of patients suffering from AIDS and they act at the final stage of viral replication by interfering with the HIV protease enzyme. The paper describes a selective, sensitive, and robust method for simultaneous determination of three protease inhibitors atazanavir, darunavir and ritonavir in human plasma by ultra performance liquid chromatography-tandem mass spectrometry.Materials and Methods. The sample pretreatment consisted of solid phase extraction of analytes and their deuterated analogs as internal standards from 50 μL human pla

APA, Harvard, Vancouver, ISO, and other styles

46

Melton, Tyler C., and Stacy D. Brown. "The Fate of Sulfamethazine in Sodium-Hypochlorite-Treated Drinking Water: Monitoring by LC--IT-TOF." International Journal of Medicinal Chemistry 2012 (May 15, 2012): 1–6. http://dx.doi.org/10.1155/2012/693903.

Full text

Abstract:

Pharmaceutical compounds represent a rapidly emerging class of environmental contaminants. Such compounds were recently classified by the U.S. Geological Survey, including several antibiotics. An LC-MS/MS screening method for the top five antibiotics in drinking water was developed and validated using a Shimadzu LC-MS-IT-TOF. The separation was performed using a Waters Acquity UPLC BEH C18 column with a gradient elution. Sulfamethazine was exposed to conditions intended to mimic drinking water chlorination, and samples were collected and quenched with excess sodium sulfite. Kinetics of sulfame

APA, Harvard, Vancouver, ISO, and other styles

47

Deepakumari, H. N., K. B. Vinay, and H. D. Revanasiddappa. "Development and Validation of a Stability Indicating RP-UPLC Method for Analysis of Imipramine Hydrochloride in Pharmaceuticals." ISRN Analytical Chemistry 2013 (August 21, 2013): 1–10. http://dx.doi.org/10.1155/2013/913765.

Full text

Abstract:

The objective of the current study was the development of a simple, rapid, and accurate isocratic reverse-phase ultra-performance liquid chromatographic (RP-UPLC) method for the routine control analysis of imipramine hydrochloride (IMH) in bulk drug and in pharmaceutical formulations. This work was carried out in order to reduce analysis time and maintaining good efficiency which in turn is focused on high-speed chromatographic separations. The method was developed using Waters Acquity BEH C18 column (100 mm × 2.1 mm, 1.7 μm) with mobile phase consisting of a mixture of acetonitrile and ammoni

APA, Harvard, Vancouver, ISO, and other styles

48

Jeong, Ji Hyun, Seon Yu Lee, Bo Na Kim, Guk Yeo Lee, and Seong Ho Ham. "Development of Simultaneous Analysis of Thirteen Bioactive Compounds in So-Cheong-Ryong-Tang Using UPLC-DAD." Journal of Analytical Methods in Chemistry 2018 (2018): 1–10. http://dx.doi.org/10.1155/2018/2875681.

Full text

Abstract:

So-Cheong-Ryong-Tang, which is a standardized Korean medicine of the National Health Insurance, is a traditional prescription for the treatment of allergic rhinitis, bronchitis, and bronchial asthma. Simultaneous analysis and development of SCRT is essential for its stability, efficacy, and risk management. In this study, a simple, reliable, and accurate method using ultrahigh-performance liquid chromatography (UPLC) fingerprinting with a diode array detector (DAD) was developed for the simultaneous analysis. The chromatographic separation of the analytes was performed by an ACQUITY UPLC BEH C

APA, Harvard, Vancouver, ISO, and other styles

49

Nguyen, Thi Anh Nguyet, Huynh Thanh Tuyen Nguyen, Van Huan Le, and Thi Van Anh Tran. "Method development for the simultaneous quantification of orcinol glucoside and curculigoside in Curculigo orchioides by UPLC-PDA." Ministry of Science and Technology, Vietnam 65, no. 9 (2023): 28–33. http://dx.doi.org/10.31276/vjst.65(9).28-33.

Full text

Abstract:

In Vietnam, the rhizomes of Curculigo orchioides have been traditionally used for the treatment of cough, impotence, cold uterus, etc. The phenolic compounds were determined as active constituents of C. orchioides; however, there is no quantitative criterion for these compounds in C. orchioides in the Vietnamese Pharmacopoeia. Therefore, this study aimed to develop a simultaneous quantification method for orcinol glucoside (OG) and curculigoside (CG) by UPLC-PDA system, required for the standardisation of C. orchioides rhizome. The simultaneous quantification of OG and CG was performed on the

APA, Harvard, Vancouver, ISO, and other styles

50

Ying, Zheming, Guoyuan Sui, Lianqun Jia, and Guanlin Yang. "Simultaneous Determination of Three Compounds in Rat Plasma by UHPLC-QQQ-MS/MS and Its Application to Pharmacokinetics of Banxia Baizhu Tianma Tang." Journal of Analytical Methods in Chemistry 2023 (January 14, 2023): 1–10. http://dx.doi.org/10.1155/2023/5119997.

Full text

Abstract:

A rapid and highly selective and sensitive ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry (UHPLC-QQQ-MS/MS) method was applied to simultaneously determine ephedrine, gastrodin, and liquiritin in rat plasma. The three analytes and vitexin-2″-O-rhamnoside (I.S.) were analyzed on a Waters Acquity UPLC C18 column (1.7 μm, 2.1 mm × 100 mm) at 30°C with gradient mobile phase consisting of 0.1% formic acid aqueous solution (A) and acetonitrile (B) after one-step direct protein precipitation with acetonitrile. The detection was performed by multiple react

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!