Relevant bibliographies by topics / Wax-printed microfluidic paper based analytical devices (μPADs)

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  1. Journal articles
  2. Dissertations / Theses
  3. Conference papers

Academic literature on the topic 'Wax-printed microfluidic paper based analytical devices (μPADs)'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Wax-printed microfluidic paper based analytical devices (μPADs)"

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Ozer, Tugba, Catherine McMahon, and Charles S. Henry. "Advances in Paper-Based Analytical Devices." Annual Review of Analytical Chemistry 13, no. 1 (June 12, 2020): 85–109. http://dx.doi.org/10.1146/annurev-anchem-061318-114845.

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Microfluidic paper-based analytical devices (μPADs) are the newest generation of lab-on-a-chip devices and have made significant strides in both our understanding of fundamental behavior and performance characteristics and expansion of their applications. μPADs have become useful analytical techniques for environmental analysis in addition to their more common application as medical point-of-care devices. Although the most common method for device fabrication is wax printing, numerous other techniques exist and have helped address factors ranging from solvent compatibility to improved device function. This review highlights recent reports of fabrication and design, modes of detection, and broad applications of μPADs. Such advances have enabled μPADs to be used in field and laboratory studies to address critical needs in fast, cheaper measurement technologies.
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Yu, Ling, and Zhuan Zhuan Shi. "Microfluidic paper-based analytical devices fabricated by low-cost photolithography and embossing of Parafilm®." Lab on a Chip 15, no. 7 (2015): 1642–45. http://dx.doi.org/10.1039/c5lc00044k.

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The combination of photolithography-patterning and embossing of a Parafilm® can fabricate microfluidic paper-based analytical devices (μPADs) without the use of a wax printer, cutter plotter and wet-chemical processing of paper.
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Shibata, Hiroyuki, Yuki Hiruta, and Daniel Citterio. "Fully inkjet-printed distance-based paper microfluidic devices for colorimetric calcium determination using ion-selective optodes." Analyst 144, no. 4 (2019): 1178–86. http://dx.doi.org/10.1039/c8an02146e.

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Teepoo, Siriwan, Supattra Arsawiset, and Pitchayatida Chanayota. "One-Step Polylactic Acid Screen-Printing Microfluidic Paper-Based Analytical Device: Application for Simultaneous Detection of Nitrite and Nitrate in Food Samples." Chemosensors 7, no. 3 (September 9, 2019): 44. http://dx.doi.org/10.3390/chemosensors7030044.

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In this work, we report a one-step approach for fabricating screened-printed microfluidic paper-based analytical devices (μPADs) using polylactic acid as a new hydrophobic material. A polylactic acid solution was screen printed onto chromatography papers to create hydrophobic patterns for fluidic channels. The optimal polylactic acid concentration for successful device fabrication is 9% w/v. The μPADs were fabricated within 2 min and provided high reproducibility and stability. The utility of polylactic acid screen-printing was demonstrated for the simultaneous detection of nitrite and nitrate using colorimetric detection. Under optimized experimental conditions, the detection limits and the linear ranges, respectively, were 1.2 mg L−1 and 2–10 mg L−1 for nitrite and 3.6 mg L−1 and 10–50 mg L−1 for nitrate. The detection times for both ions were found to be within 12 min. The developed μPAD was applied for the simultaneous determination of these ions in food samples, and no significant differences in the analytical results were observed compared to those of the reference method. The polylactic acid screen-printing approach presented here provides a simple, rapid, and cost-effective alternative fabrication method for fabricating μPADs.
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Strong, E., Carsten Knutsen, Jay Wells, Aditya Jangid, Megan Mitchell, Nathaniel Martinez, and Andres Martinez. "Wax-Printed Fluidic Time Delays for Automating Multi-Step Assays in Paper-Based Microfluidic Devices (MicroPADs)." Inventions 4, no. 1 (March 19, 2019): 20. http://dx.doi.org/10.3390/inventions4010020.

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Microfluidic paper-based analytical devices (microPADs) have emerged as a promising platform for point-of-care diagnostic devices. While the inherent wicking properties of microPADs allow for fluid flow without supporting equipment, this also presents a major challenge in achieving robust fluid control, which becomes especially important when performing complex multi-step assays. Herein, we describe an ideal method of fluid control mediated by wax-printed fluidic time delays. This method relies on a simple fabrication technique, does not utilize chemicals/reagents that could affect downstream assays, is readily scalable, and has a wide temporal range of tunable fluid control. The delays are wax printed on both the top and bottom of pre-fabricated microPAD channels, without subsequent heating, to create hemi-/fully-enclosed channels. With these wax printed delays, we were able to tune the time it took aqueous solutions to wick across a 25 mm-long channel between 3.6 min and 13.4 min. We then employed these fluid delays in the sequential delivery of four dyes to a test zone. Additionally, we demonstrated the automation of two simple enzymatic assays with this fluid control modality. This method of fluid control may allow future researchers to automate more complex assays, thereby further advancing microPADs toward real-world applications.
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Jarujamrus, Purim, Rattapol Meelapsom, Puttharaksa Naksen, Nadh Ditcharoen, Wipark Anutrasakda, Atitaya Siripinyanond, Maliwan Amatatongchai, and Saksri Supasorn. "Screen-printed microfluidic paper-based analytical device (μPAD) as a barcode sensor for magnesium detection using rubber latex waste as a novel hydrophobic reagent." Analytica Chimica Acta 1082 (November 2019): 66–77. http://dx.doi.org/10.1016/j.aca.2019.06.058.

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Montgomery, R. Hunter, Kelsey Phelan, Sawyer D. Stone, Francois Decuir, and Bryant C. Hollins. "Photolithography-free PDMS stamps for paper microdevice fabrication." Rapid Prototyping Journal 24, no. 2 (March 12, 2018): 361–67. http://dx.doi.org/10.1108/rpj-01-2017-0011.

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Purpose This paper aims to investigate the applicability of 3D-printed molds to be used as a substitute for photolithography in the formation of polymer-based stamps. It proposes leveraging 3D printing as a rapid prototyping tool to be applied to microfluidic fabrication. Design/methodology/approach Different designs are created using computer-aided design (CAD) software and printed via Makerbot 3D printer. The molds serve as negative reliefs for a PDMS stamp. The stamp is used to apply paraffin wax to chromatography paper, creating hydrophobic barriers and hydrophilic channels. The minimum functional channel widths and barrier widths are determined for the method. Findings The method is demonstrated to be effective for bypassing the more cost-prohibitive photolithography approach for rapid paper microdevice fabrication. This approach produces functional channels that can be used for on-chip analytical assays. The minimum functional barrier widths and minimum functional channel widths are in good agreement with other published methods for paper-based microchannel fabrication. Research limitations/implications The approach cannot generate the high-resolution structures possible with photolithography. Therefore, if higher resolutions are needed for a particular application, this approach is not the best. Practical implications The simplicity of the approach introduces an affordable method to create disposable devices that can be used at the point of testing. Originality/value The paper satisfies a need for inexpensive, rapid prototyping of paper-based devices. The method is simple and can be used as a tool for introducing labs to microfluidics research.
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Meng, Haixu, Chang Chen, Yonggang Zhu, Zhengtu Li, Feng Ye, Joshua Wing Kei Ho, and Huaying Chen. "Automatic flow delay through passive wax valves for paper-based analytical devices." Lab on a Chip, 2021. http://dx.doi.org/10.1039/d1lc00638j.

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Microfluidic paper-based analytical devices (μPADs) have been widely explored for point-of-care testing due to their simplicity, low cost, and portability. μPADs with multiple-step reactions usually require precise flow control, especially...
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Zhang, Han, Ethan Smith, Wei Zhang, and Anhong Zhou. "Inkjet printed microfluidic paper-based analytical device (μPAD) for glucose colorimetric detection in artificial urine." Biomedical Microdevices 21, no. 3 (June 10, 2019). http://dx.doi.org/10.1007/s10544-019-0388-7.

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Dissertations / Theses on the topic "Wax-printed microfluidic paper based analytical devices (μPADs)"

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Lahr, Rebecca Halvorson. "Advanced Applications of Raman Spectroscopy for Environmental Analyses." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/54010.

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Due to an ever-increasing global population and limited resource availability, there is a constant need for detection of both natural and anthropogenic hazards in water, air, food, and material goods. Traditionally a different instrument would be used to detect each class of contaminant, often after a concentration or separation protocol to extract the analyte from its matrix. Raman spectroscopy is unique in its ability to detect organic or inorganic, airborne or waterborne, and embedded or adsorbed analytes within environmental systems. This ability comes from the inherent abilities of the Raman spectrometer combined with concentration, separation, and signal enhancement provided by drop coating deposition Raman (DCDR) and surface-enhanced Raman spectroscopy (SERS). Herein the capacity of DCDR to differentiate between cyanotoxin variants in aqueous solutions was demonstrated using principal component analysis (PCA) to statistically demonstrate spectral differentiation. A set of rules was outlined based on Raman peak ratios to allow an inexperienced user to determine the toxin variant identity from its Raman spectrum. DCDR was also employed for microcystin-LR (MC-LR) detection in environmental waters at environmentally relevant concentrations, after pre-concentration with solid-phase extraction (SPE). In a cellulose matrix, SERS and normal Raman spectral imaging revealed nanoparticle transport and deposition patterns, illustrating that nanoparticle surface coating dictated the observed transport properties. Both SERS spectral imaging and insight into analyte transport in wax-printed paper microfluidic channels will ultimately be useful for microfluidic paper-based analytical device (𝜇PAD) development. Within algal cells, SERS produced 3D cellular images in the presence of intracellularly biosynthesized gold nanoparticles (AuNP), documenting in detail the molecular vibrations of biomolecules at the AuNP surfaces. Molecules involved in nanoparticle biosynthesis were identified at AuNP surfaces within algal cells, thus aiding in mechanism elucidation. The capabilities of Raman spectroscopy are endless, especially in light of SERS tag design, coordinating detection of analytes that do not inherently produce strong Raman vibrations. The increase in portable Raman spectrometer availability will only facilitate cheaper, more frequent application of Raman spectrometry both in the field and the lab. The tremendous detection power of the Raman spectrometer cannot be ignored.
Ph. D.
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Kripalani, Rishi A. "Novel Integration of Conductive-ink Circuitry with a Paper-based Microfluidic Battery as an All-printed Sensing Platform." DigitalCommons@CalPoly, 2016. https://digitalcommons.calpoly.edu/theses/1694.

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The addition of powered components for active assays into paper-based analytical devices opens new opportunities for medical and environmental analysis in resource-limited applications. Current battery designs within such devices have yet to adopt a ubiquitous circuitry material, necessitating investigation into printed circuitry for scalable platforms. In this study, a microfluidic battery was mated with silver-nanoparticle conductive ink to prototype an all-printed sensing platform. A multi-layer, two-cell device was fabricated, generating 200 μA of direct electrical current at 2.5 V sustained for 16 minutes with a power loss of less than 0.1% through the printed circuitry. Printed circuitry traces exhibited resistivity of 75 to 211 10-5 Ω m. Resistance of the printed traces increased upwards of 200% depending on fold angle and directionality. X-ray diffraction confirmed the presence of face-centered cubic silver after sintering printed traces for 30 minutes at 150°C in air. A conductivity threshold was mapped and an ink concentration of 0.636 μL mm-3 was identified as the lower limit for optimal electrical performance.
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Conference papers on the topic "Wax-printed microfluidic paper based analytical devices (μPADs)"

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Zamri, N. L., and M. H. M. Salleh. "Investigation of liquid flow interaction on wax and cut channel paper-based microfluidic analytical device (μPAD)." In 7th Brunei International Conference on Engineering and Technology 2018 (BICET 2018). Institution of Engineering and Technology, 2018. http://dx.doi.org/10.1049/cp.2018.1569.

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