Journal articles on the topic 'Wei li bao'

Introduction. Based on the analysis of Chinese scholars’ works in the field of area studies, such problem as the uneven development of the territory of China has been identified. Intense social and economic transformations in China at the end of the 20th century influenced the emergence of regional problems, the solution of which was possible only through the competent regional policy of the Chinese leadership. As part of the study of regional disproportionality, Chinese researchers highlight the characteristic features inherent in each of the provinces and autonomous regions of the Northeast, North, East, Central South, South West and North West regions of China. These research are based on the study of economic agglomeration, regional division and features of regional management. Methods. On the basis of the method of logical analysis, the features of the formation of regional knowledge in China within the framework of borrowing the theoretical and methodological base of Western European and American science of the region have been determined. The use of a systematic approach in the analysis of Chinese-language scientific literature revealed one of the key problems in the field of national regional studies of China, namely the problem of uneven regional development of China. Analysis. Analysis of Chinese-language scientific literature allows the author to identify four main groups of reasons: geographical, historical, cultural, economic, underlying the disproportionate regional development of China. The author analyzes scientific articles and monographs of leading Chinese scholars published not only in China, but also in the United States. The works of Chinese authors Bao Yuan, Wang Xuanxuan, Wei Yehua, Li Zhuni, Luo Yu, Lu Zunhua, Wu Peng, Hu Zhaoliang, Zhang Wei, Chiang Lexiang contain a comprehensive analysis of the imbalance of the socioeconomic development of China’s regions. Results. Results of this paper can be summarized in the following points: the study of the causes of uneven development of the territory of China will allow to more objectively perceive the origins of modern domestic regional problems in China and identify the features of the use of the results of scientific work of Chinese scientists in the formation of regional policy to eliminate socio-economic disproportion in the development of China.

The wave force dose not considered at the formula of mooring ship cable force in the Load Code for Harbor Engineering[JTJ215-98]. This brought the inconvenience to the calculation of designed cable force for mooring ship. By means of analysis for the laboratory model test result of mooring ship cable force under wave effect, Wave force formula of mooring ship under wave effect was gained. This formula well reflected the influence of ship size, ship load , ship rolling period, ship pitch period, wave period and wave height. The formula can be used in the calculation of standard value of mooring ship cable force under the wave effection, also it can be used to instruct the wave model test for mooring ship. References Zhang Ri-xiang. Liu Zhong-bo. Zhang Ning-chuan. 2003 .An Experimental Study on the Mooring Line Forces & Impact Forces of a Moored Ship Under the Combined Action of Wind,Wave and Current [J].,China offshore Platform, (01).15-18. Li Yan. Zheng Bao-you.Gao Feng. Meng Xiang-wei.2007.Model test study on the impact forces and mooring line forces of a moored ship under the combined action of wave and current [J].;The Ocean Engineering, (02).57-63. Ministry of transport of the People's Republic of China(1998).The Load Code for Harbor Engineering(JTJ215-98). [S]. Jiang Qing. Ge Hong-zheng.Xie Peng.2007.Influence of Ship's Type and Tonnage on the Ship's Mooring Force [J]. Port & Waterway Engineering, (09).51-59. Wu Xiuhuan. 1999.Ship and maneuverability and seakeeping [M]. Ministry of transport of the People's Republic of China. p220. Zhang Wen-zhong. Etc.(2006): Model test of Mooring LNG ship at Jiangsu Provence, Tianjin Port Engineering Institute Ltd. of CCCC.

Методом цитратной золь-гель технологии получен новый двойной борат рубидия–гольмия состава Rb3HoB6O12. Соединение кристаллизуется в тригональной сингонии (пр. гр. R32, a = 13.4038(7), с = 30.315(2) Å, V = 4716.76 Å3) и плавится инконгруэнтно при 818 °С. Попытки получить в однофазном состоянии Rb3HoB6O12 методом твердофазных реакций не привели к положительному результату REFERENCES Wu C., Yang G., Humphrey M.G., Zhang C. Recent advances in ultraviolet and deep-ultraviolet secondorder nonlinear optical crystals // Chem. Rev., 2018, v. 375, pp. 1–30. https://doi.org/10.1016/j.ccr.2018.02.017 Bubnova R., Volkov S., Albert B., Filatov S. Borates – crystal structures of prospective nonlinear optical materials: high anisotropy of the thermal expansion caused by anharmonic atomic vibrations // Crystals, 2017, v. 7, pp.1–32. DOI: 10.3390/cryst7030093 Becker P. Borate materials in nonlinear optics // Mater., 1998, v. 10, pp. 979–992. https://doi.org/10.1002/(SICI)1521-4095(199809)10:13<979::AIDADMA979>3.0.CO;2-N Chen C., Li R. The anionic group theory of the nonlinear optical effect and its applications in the development of new high-quality NLO crystals in the borate series // Rev. Phys. Chem., 1988, v. 8, pp. 65–91. https://doi.org/10.1080/01442358909353223 Chen C., Wu Y., Jiang A., Wu B., You G., Li R., Lin S. New nonlinear-optical crystal: LiB3O5 // Opt. Soc. Am. B: Opt. Phys., 1989, v. 6, pp. 616–621. https://doi.org/10.1364/JOSAB.6.000616 French R. H., Ling J. W., Ohuchi F. S., Chen C. T. Electronic structure of b-BaB2O4 and LiB3O5 nonlinear optical crystals // Rev. B: Condens. Matter, 1991, v. 44, pp. 8496–8502. https://doi.org/10.1103/Phys-RevB.44.8496 Yusuke Mori, Ikio Kuroda, Satoshi Nakajima, Takamoto Sasaki, Sadao Nakai. New nonlinear optical crystal: Cesium lithium borate // Phys. Lett., 1995, v. 67, pp. 1818–1820. https://doi.org/10.1063/1.115413 Haohai Yu, Zhongben Pan, Huaijin Zhang, Jiyang Wang. Recent advances in self-frequency-doubling crystals // Materiomics, 2016, v. 2, pp. 55–65. https://doi.org/10.1016/j.jmat.2015.12.001 Bajor A.L., Kisielewski J., Klos A., Kopzyński K., Lukasiewicz T., Mierczyk J., Mlyńczak J. Assessment of gadolinium calcium oxoborate (GdCOB) for laser applications // Opto-electronics Review, 2011, v. 19, pp. 439–448. https://doi.org/10.2478/s11772-011-0042-2 Dan Zhao, Cong-Kui Nie, Ye Tian, Bao-Zhong Liu, Yun-Chang Fan, Ji Zhao. A new luminescent host material K3GdB6O12: synthesis, crystal structure and luminescent properties activated by Sm3+ // Kristallogr., 2018, v. 233, pp. 411–419. https://doi.org/10.1515/zkri-2017-2101 Dan Zhao, Fa-Xue Ma, Rui-Juan Zhang, Wei Wei, Juan Yang, Ying-Jie Li. A new rare-earth borate K3LuB6O12: crystal and electronic structure, and luminescent properties activated by Eu3+ // Mater Sci: Mater Electron., 2017, pp. 1–9. https://doi.org/10.1007/s10854-016-5501-6 Atuchin V. V., Subanakov A. K., Aleksandrovsky A. S., Bazarov B. G., Bazarova J. G., Dorzhieva S. G., Gavrilova T. A., Krylov A. S., Molokeev M. S., Oreshonkov A. S., Pugachev A. M., Tushinova Yu. L., Yelisseyev A. P. Exploration of structural, thermal, vibrational and spectroscopic properties of new noncentrosymmetric double borate Rb3NdB6O12 // Powder Technol., 2017, v. 28, pp. 1309–1315. https://doi.org/10.1016/j.apt.2017.02.019 Atuchin V. V., Subanakov A. K., Aleksandrovsky A. S., Bazarov B. G., Bazarova J. G., Gavrilova T. A., Krylov A. S., Molokeev M. S., Oreshonkov A. S., Stefanovich S. Yu. Structural and spectroscopic properties of new noncentrosymmetric selfactivated borate Rb3EuB6O12 with B5O10 units // Des., 2018, v. 140, pp. 488–494. https://doi.org/10.1016/j.matdes.2017.12.004 Sangen Zhao, Guochun Zhang, Jiyong Yao, Yicheng Wu. K3YB6O12: A new nonlinear optical crystal with a short UV cutoff edge // Res. Bull., 2012, v. 47, pp. 3810–3813. https://doi.org/10.1016/j.materresbull.2012.05.062 Miriding Mutailipu, Zhiqing Xie, Xin Su, Min Zhang, Ying Wang, Zhihua Yang, Muhammad Ramzan Saeed Ashraf Janjua, Shilie Pan. Chemical cosubstitution- oriented design of rare-earth borates as potential ultraviolet nonlinear optical materials // Am. Chem. Soc., 2017, v. 139, pp. 18397–18405. https://doi.org/10.1021/jacs.7b11263 Li Yang, Yingpeng Wan, Honggen Weng, Yanlin Huang, Cuili Chen, Hyo Jin Seo. Luminescence and color center distributions in K3YB6O12 : Ce3+ phosphor // Phys. D: Appl. Phys., 2016, v. 49 (325303), pp. 1–12. https://doi.org/10.1088/0022-3727/49/32/325303

The paper discusses the early days of translation in China which began with the translation of Buddhist texts from Sanskrit into Chinese. The article addresses one of the most difficult and dramatic periods in the history of translation activities, the era of Three Kingdoms (220-280). First efforts of the Buddhist missionaries in translating the Buddhist texts from Sanskrit into Chinese are poorly studied in the Russian science. The article aims to fill the gap. This goal sets the following tasks: (1) to analyze the translation activities in the kingdoms of Wei (220–265) and Wu (222–280) during Three Kingdoms period; (2) to show the place and role of the translators of these kingdoms in the development of the translation tradition in China; (3) to consider the quality of the Buddhist texts translations and their contribution to the development of Buddhism in China. The study shows that Buddhist missionaries who came to China from India and the countries of Central Asia during the Three Kingdoms period played an important role in the spreading of Buddhism. Their search for methods and tools to give the sense of Sanskrit texts in Chinese, which experience had had no experience of assimilation before Buddhism, prepared a fertile ground for the emergence in China of such translations of Buddhist literature that were able to convey the exact meaning of Buddhist teachings. The activities of the Three Kingdoms Buddhist texts translators reflected the rise of Indian Mahayana Buddhism and its texts formation. The article draws on bibliographic works of medieval authors: Hui Jiao’s “Gao Sen Zhuan” (“Biography of worthy monks”), Sen Yu’s “Chu San Zang Ji Ji” (“Collection of Translation Information about Tripitaka”), Fei Changfang’s “Li Dai San Bao Ji” (“Information about the three treasuries [during] historical epochs”), which figure prominently in Buddhist historiography. Also the authors draw on the latest Chinese research summarized in the monograph: Lai Yonghai (ed.). “Zhongguo fojiao tongshi” [General History of Chinese Buddhism]. Nanjing, 2006.

Objetivo: Esse estudo objetivou investigar percepções de estudantes de Odontologia quanto ao medo e à ansiedade em relação ao manejo de pacientes e ao risco de infecção por COVID-19. Materiais e métodos: Esse estudo transversal envolveu todos os alunos regularmente matriculados em Odontologia, no primeiro semestre de 2020, da Universidade Federal de Pelotas. Um questionário foi aplicado, coletando dados demográficos, nível de formação e perguntas relacionadas ao medo e ansiedade frente à pandemia de COVID-19. Quatro comparações de acordo com a fase da graduação (fase pré-clínica ou clínica), nível de graduação e pós-graduação e de acordo com os sexos foram feitas. Análises independentes para as comparações entre os sexos foram realizadas para os alunos de graduação e de pós-graduação (α<5%). Resultados: Foram incluídos 408 estudantes. Na graduação, mulheres relataram sentirem-se mais ansiosas ao realizar tratamento em pacientes com suspeita de COVID-19 (54%) e sentem mais medo ao ouvir que a infecção tem causado mortes (92,4%), na pós-graduação, responderam ser mais nervosas para conversar com pacientes em ambientes fechados em comparações com homens (P<0,05). Alunos em fase pré-clínica possuem significativamente menor receio (65,5%), ansiedade (32,3%) e nervosismo (28,3%) do contágio do COVID-19 quando comparados com aqueles na fase clínica. Conclusões: Mulheres e alunos na fase clínica apresentam maior ansiedade e nervosismo. Descritores: Ansiedade; Estudantes de Odontologia; Medo; Infecções por Coronavírus. Referências Chang J, Yuan Y, Wang D. [Mental health status and its influencing factors among college students during the epidemic of COVID-19]. Nan Fang Yi Ke Da Xue Xue Bao. 2020;40(2):171-176. World Health Organization. WHO Director-General’s opening remarks at the media briefing on COVID-19- 11 March 2020. 2020. Disponível em: https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020. Acesso em: 8 de novembro de 2020. Pascarella G, Strumia A, Piliego C, Bruno F, Del Buono R, Costa F, Scarlata S, Agrò FE. COVID-19 diagnosis and management: a comprehensive review. J Intern Med. 2020;288(2):192-206. Chen E, Lerman K, Ferrara E. Tracking Social Media Discourse About the COVID-19 Pandemic: Development of a Public Coronavirus Twitter Data Set. JMIR Public Health Surveill. 2020;6(2):e19273. Iyer P, Aziz K, Ojcius DM. Impact of COVID-19 on dental education in the United States. J Dent Educ. 2020;84(6):718-722. Meng L, Hua F, Bian Z. Coronavirus Disease 2019 (COVID-19): Emerging and Future Challenges for Dental and Oral Medicine. J Dent Res. 2020;99(5):481-487. Peng X, Xu X, Li Y, Cheng L, Zhou X, Ren B. Transmission routes of 2019-nCoV and controls in dental practice. Int J Oral Sci. 2020;12(1):9. Machado RA, Bonan PRF, Perez DEDC, Martelli Júnior H. COVID-19 pandemic and the impact on dental education: discussing current and future perspectives. Braz Oral Res. 2020;34:e083. Ataş O, Talo Yildirim T. Evaluation of knowledge, attitudes, and clinical education of dental students about COVID-19 pandemic. PeerJ. 2020;8:e9575. Deery C. The COVID-19 pandemic: implications for dental education. Evid Based Dent. 2020;21(2):46-47. Basudan S, Binanzan N, Alhassan A. Depression, anxiety and stress in dental students. Int J Med Educ. 2017;8:179-186. Elani HW, Allison PJ, Kumar RA, Mancini L, Lambrou A, Bedos C. A systematic review of stress in dental students. J Dent Educ. 2014; 78(2):226-42. Sahu P. Closure of Universities Due to Coronavirus Disease 2019 (COVID-19): Impact on Education and Mental Health of Students and Academic Staff. Cureus. 2020;12(4):e7541. Ahmed MA, Jouhar R, Ahmed N, Adnan S, Aftab M, Zafar MS, Khurshid Z. Fear and Practice Modifications among Dentists to Combat Novel Coronavirus Disease (COVID-19) Outbreak. Int J Environ Res Public Health. 2020;17(8):2821. Talevi D, Socci V, Carai M, Carnaghi G, Faleri S, Trebbi E, di Bernardo A, Capelli F, Pacitti F. Mental health outcomes of the CoViD-19 pandemic. Riv Psichiatr. 2020;55(3):137-44. Mijiritsky E, Hamama-Raz Y, Liu F, Datarkar AN, Mangani L, Caplan J, Shacham A, Kolerman R, Mijiritsky O, Ben-Ezra M, Shacham M. Subjective Overload and Psychological Distress among Dentists during COVID-19. Int J Environ Res Public Health. 2020;17:5074. Rymarowicz J, Stefura T, Major P, Szeliga J, Wallner G, Nowakowski M, Pędziwiatr M. General surgeons' attitudes towards COVID-19: A national survey during the SARS-CoV-2 virus outbreak. Eur Surg. 2020;1-6. Adams JG, Walls RM. Supporting the Health Care Workforce During the COVID-19 Global Epidemic. JAMA. 2020;323(15):1439-40. Naz N, Iqbal S, Mahmood A. Stress, anxiety and depression among the dental students of university college of medicine and dentistry Lahore; Pakistan. Pak J Med Health Sci. 2017;11(4):1277-81. Waqas A, Iftikhar A, Malik Z, Aedma KK, Meraj H, Naveed S. Association of severity of depressive symptoms with sleep quality, social support and stress among Pakistani medical and dental students: A cross-sectional study. Global Psychiatry. 2019;2(2):211-20. Wang Y, Di Y, Ye J, Wei W. Study on the public psychological states and its related factors during the outbreak of coronavirus disease 2019 (COVID-19) in some regions of China. Psychol Health Med. 2020;1-10. Xiong J, Lipsitz O, Nasri F, Lui LMW, Gill H, Phan L, Chen-Li D, Iacobucci M, Ho R, Majeed A, McIntyre RS. Impact of COVID-19 pandemic on mental health in the general population: A systematic review. J Affect Disord. 2020;277:55-64. Liu N, Zhang F, Wei C, Jia Y, Shang Z, Sun L, Wu L, Sun Z, Zhou Y, Wang Y, Liu W. Prevalence and predictors of PTSS during COVID-19 outbreak in China hardest-hit areas: Gender differences matter. Psychiatry Res. 2020;287;112921. Terán E, Mayta-Tovalino F. Risk Factors, Self-perceived Stress, and Clinical Training among Dentistry Students in Peru: A Cross-sectional Study. J Contemp Dent Pract. 2019;20(5):561-5. Uraz A, Tocak YS, Yozgatligil C, Cetiner S, Bal B. Psychological well-being, health, and stress sources in Turkish dental students. J Dent Educ. 2013:77(10):1345-55. Agius AM, Gatt G, Vento Zahra E, Busuttil A, Gainza-Cirauqui ML, Cortes ARG et al. Self-reported dental student stressors and experiences during the COVID-19 pandemic. J Dent Educ. 2020. doi: 10.1002/jdd.12409. Hu J, Zou H, Dai Y, Feng Z. How to keep students engaged in oral health education during the COVID-19 pandemic. J Dent Educ. 2020. doi: 10.1002/jdd.12420. Liu S, Yang L, Zhang C, Xiang YT, Liu Z, Hu S, Zhang B. Online mental health services in China during the COVID-19 outbreak. Lancet Psychiatry. 2020;7(4):e17-8. Maia BR, Dias PC. Anxiety, depression and stress in university students: the impact of COVID-19. Estudos de Psicologia (Campinas). 2020;37:e200067.

Relato sentimental de uma leitura dos Poemas Clássicos Chineses, tradução de Sérgio Capparelli e Sun Yuqi. Lançado em 2012, pela editora L&PM de Porto Alegre, Brasil. O livro contém uma tradução de três poetas máximos da Literatura Chinesa, a saber: Li Bai, Du Fu e Wang Wei (todos eles da dinastia Tang, séc. VIII d. C.). O livro dos tradutores brasileiros será tratado com múltiplas referências ao clássico de Lao Tzu (老子), o Tao Te Ching (道德經, séc. VI a.C.), e ao poema do escritor português Camilo Pessanha (1867-1926), “Ao longe os barcos de flores” (1899).

Two new species of the genus are described from Zhejiang, China in this paper. The new species Criotettix jinningensis sp. nov. is similar to Criotettix strivertexoides Zheng, Wei & Li, 2009, but differs in width of vertex narrower than diameter of eye; pronotum shorter, not reaching the end of hind tibiae; width of fore wing 1.3 times width of mid leg femur and hind wing not reaching the end of pronotum. The new species Criotettix pananensis sp. nov. is similar to Criotettix transpi-noides Zheng, Bai & Xu, 2012, it differs from latter by width of vertex narrower than diameter of eye; pronotum with parallel lateral keels and without a pair short longitudinal keels between shoulders; hind femur without projection in upper keel and hind wing extending over the end of pronotum. The type specimens are deposited in the College of Life Sciences, Hebei University, Baoding, China.

Introdução: A tomografia computadorizada de feixe cônico (TCFC) consiste em um moderno sistema de imagens radiográficas criado especificamente para a análise do complexo maxilofacial. Devido às limitações apresentadas pelas radiografias convencionais, esse exame mostra-se de grande importância para o diagnóstico endodôntico, pois apresenta diversas vantagens como melhor qualidade de imagem, reconstrução tridimensional e as doses de radiação mais baixas. Objetivo: Enfatizar, por meio de um relato de caso, a importância da TCFC como método auxiliar de diagnóstico na localização de canais radiculares. Relato de caso: Paciente do sexo feminino, 25 anos de idade, procurou atendimento odontológico com queixa de dor à mastigação no dente 14, que já havia sido tratado endodonticamente há um ano e retratado há seis meses. Após realização de radiografia periapical, observou-se uma imagem radiolúcida envolvendo o ápice do dente 14. Diante disso, realizou-se uma TCFC, a qual revelou a presença de um canal não obturado. Com bases nos achados, optou-se por uma nova intervenção endodôntica em duas sessões, sendo que, na segunda sessão, a paciente encontrava-se assintomática e sem edema na região. Após um ano de proservação, a paciente não relatou sintomatologia dolorosa e nenhum sinal de infecção foi observado. Conclusão: Dessa forma, foi possível concluir que a TCFC constituiu-se como um método preciso para auxiliar no diagnóstico, pois permitiu a visualização de um canal radicular não instrumentado, além de permitir um melhor direcionamento do plano de tratamento.Descritores: Tomografia Computadorizada de Feixe Cônico; Endodontia; Complicações Intraoperatórias.ReferênciasDurack C, Patel S. Cone beam computed tomography in endodontics. Braz Dent J. 2012;23(3):179-91.Falcão CA, Albuquerque VC, Amorim NL, Freitas SA, Santos TC, Matos FT, Ferraz MA. Frequency of the mesiopalatal canal in upper first permanent molars viewed through computed tomography. Acta Odontol Latinoam. 2016;29(1):54-9.Dalili Kajan Z, Taramsari M, Khosravi Fard N, Kanani M. Accuracy of Cone-beam Computed Tomography in Comparison with Standard Method in Evaluating Root Canal Morphology: An In Vitro Study. Iran Endod J. 2018; 13(2):181-87. Cardona-Castro JA; Fernández-Grisaies R. Root anatomy, a view from the microsurgery endodontic: review. CES odontol. 2015;28(2):70-99.Aminoshariae A, Kulild JC, Syed A. Cone-beam computed tomography compared with intraoral radiographic lesions in endodontic outcome studies: a systematic review. J Endod. 2018;44(11):1626-31. Li YH, Bao SJ, Yang XW, Tian XM, Wei B, Zheng YL. Symmetry of root anatomy and root canal morphology in maxillary premolars analyzed using cone-beam computed tomography. Arch Oral Biol. 2018;94:84-92.Rajasekhara S, Sharath Chandra S, Parthasarathy LB. Cone beam computed tomography evaluation and endodontic management of permanent mandibular second molar with four roots: A rare case report and literature review. J Conserv Dent. 2014;17(4):385-88. Shetty A, Hegde MN, Tahiliani D, Shetty H, Bhat GT, Shetty S. A three-dimensional study of variations in root canal morphology using cone-beam computed tomography of mandibular premolars in a South Indian population. J Clin Diagn Res. 2014;8(8):ZC22-4. Ahmad IA, Alenezi MA. Root and Root Canal Morphology of Maxillary First Premolars: A Literature Review and Clinical Considerations. J Endod. 2016;42(6):861-72. Sagale AA, Ramugade MM, Ganga R. Endodontic Management of Mandibular Second Premolar with Type IX Canal Configuration Using Cone-Beam Computed Tomography as a Diagnostic Aid: A Rare Case Report. Contemp Clin Dent. 2018;9(Suppl 1):S180-84. Martins JNR, Gu Y, Marques D, Francisco H, Caramês J. Differences on the Root and Root Canal Morphologies between Asian and White Ethnic Groups Analyzed by Cone-beam Computed Tomography. J Endod. 2018; 44(7):1096-104. Balakasireddy K, Kumar KP, John G, Gagan C. Cone Beam Computed Tomography Assisted Endodontic Management of a Rare Case of Mandibular First Premolar with Three Roots. J Int Oral Health. 2015;7(6):107-9.Ugur Z, Akpinar KE, Altunbas D. Maxillary first premolars with three root canals: two case reports. J Istanb Univ Fac Dent. 2017;51(3):50-4.Razumova S, Brago A, Khaskhanova L, Howijieh A, Barakat H, Manvelyan A. A Cone-Beam Computed Tomography Scanning of the Root Canal System of Permanent Teeth among the Moscow Population. Int J Dent. 2018; 2018:2615746.Pan JYY, Parolia A, Chuah SR, Bhatia S, Mutalik S, Pau A. Root canal morphology of permanent teeth in a Malaysian subpopulation using cone-beam computed tomography. BMC Oral Health. 2019 Jan 14;19(1):14.Senan EM, Alhadainy HA, Genaid TM, Madfa AA. Root form and canal morphology of maxillary first premolars of a Yemeni population. BMC Oral Health. 2018;18(1):94.Fan L, Yuan K, Niu C, Ma R, Huang Z. A cone-beam computed tomography study of the mesial cervical concavity of maxillary first premolars. Arch Oral Biol. 2018;92:79-82. de Lima CO, de Souza LC, Devito KL, do Prado M, Campos CN. Evaluation of root canal morphology of maxillary premolars: a cone-beam computed tomography study. Aust Endod J. 2019;45(2):196-201. Ball RL, Barbizam JV, Cohenca N. Intraoperative endodontic applications of cone-beam computed tomography. J Endod. 2013;39(4):548-57. Kaur A, Logani A. Usefulness of cone beam computed tomography in perplexing endodontic cases. Endodontology. 2018;30:187-93.

<p><strong>Abstract.</strong> While public participation in scientific achievements has a long history, the last decades have seen more attention and an impressive increase in the number of involved people. Citizen science, the term used for denoting such an attitude, is a very diverse practice, encompassing various forms, depths, and aims of collaboration between scientists and citizen researchers and a broad range of scientific disciplines. Different classifications of citizen science projects exist based on the degrees of influence and contributions of citizens. Haklay, Mazumdar, and Wardlaw (2018) distinguish the citizen science projects in three different classes:</p> <ol><li>Long-running citizen science, which are the traditional ones, the projects similar to those run in the past (Koboriet al., 2016; Bonney et al., 2009)</li> <li>Citizen cyberscience, strictly connected with the use of technologies (Grey, 2009) and which can be subclassified in:<ol><li>volunteer computing, where citizens offer the unused computing resources of their computers;</li><li>volunteer thinking, where citizens offer their cognitive abilities for performing tasks difficult for machines;</li><li>passive sensing, where citizens use the sensors integrated into mobile computing devices to carry outautomatic sensing tasks.</li></ol></li> <li>Community science, involving a more significant commitment of citizens also in designing and planning theproject activities in a more egalitarian (if not bottom-up) approach between scientists and citizen scientists(Jepson &amp; Ladle, 2015; Nascimento, Guimarães Pereira, &amp; Ghezzi, 2014; Breen, Dosemagen, Warren, &amp;Lippincott, 2015), which can be divided into:<ol><li>participatory sensing, where citizens use the sensors integrated into mobile computing devices to carry outsensing tasks;</li><li>Do It Yourself (DIY) science, which implies participants create their scientific tools and methodology to carry out their researches; </li><li>civic science, “which is explicitly linked to community goals and questions the state of things” (Haklay et al., 2018).</li></ol></li></ol> <p>The work presented here is of interest of community scientists which voluntarily offer their time for the development of scientific projects. Many software tools have been developed in order to simplify the insertion of data into structured forms and the aggregation and analysis of the obtained data. In recent years, the growing availability of feature-rich and low-cost smartphones have boosted the development of innovative solutions for data collection using portable devices. In this field, ODK (OpenDataKit) is widely known. It is an open-source suite of tools focused on simplicity of use, which includes an Android application for data collection. We used ODK for the first applications we developed.</p><p>One of the applications we developed using ODK is Via Regina (http://www.viaregina.eu/app). The application aims to support slow tourism in Via Regina, which is a road that overlooks the west coast of Lake Como in Northern Italy. Over the centuries, Via Regina has been a critical trade and pilgrim route in Europe. Moreover, from this road, a compact system of slow mobility paths departs, which span the mountainous region at the border between Italy and Switzerland. This region is rich in culture, regarding history, art, architecture, cuisine and people’s lifestyle. Considering collecting data on Via Regina and the paths around it would enable to rediscover and promote its culture while enjoying the territory, an Interreg project named “The Paths of Regina” started. The application developed within this project allows collecting data in predefined types: historical and cultural, morphological, touristic, and critical. Moreover, while reporting a point of interest (POI), the application asks the name, the position (through GPS or an interactive map), a picture, and optionally a video and an audio record of it (Antonovic et al., 2015).</p><p>However, since ODK application can be used only on Android devices, we developed a cross-platform application to collect similar data for the same purpose. It is available on Android, iOS, and web (http://viaregina3.como.polimi.it/app/). The application is developed using Apache Cordova, which is a mobile application development framework that enables running the application in multiple platforms. Leaflet library is used for web mapping. The data is stored in NoSQL PouchDB and CouchDB database, which enables both online and offline data collection. While reporting a POI, the application asks for its type, the user’s rating, a comment, and a picture of it either uploaded from device’s storage or taken using the camera of the mobile device. In addition to being cross-platform, it has the advantage of displaying and enabling the query of POIs reported, compared to the ODK-based version (Brovelli, Kilsedar, &amp; Zamboni, 2016). Regarding citizen science, besides the citizens using these two applications, Iubilantes, a voluntary cultural organization, has been involved in the project as community scientists. Iubilantes created slow mobility paths to walk in and around Via Regina, using their experience gained through studying ancient paths while protecting and enhancing their assets since 1996.</p><p>Mobile data collection can also be used to compensate for the lack of reference data available for land cover validation. We developed the Land Cover Collector (https://github.com/kilsedar/land-cover-collector) application for this purpose, which collects data using the nomenclature of GlobeLand30. GlobeLand30 is the first global land cover map at 30-meter resolution, provided by National Geomatics Center of China, available for 2000 and 2010 (Chen et al., 2015). There are ten land cover classes in the GlobeLand30 dataset, which are: artificial surface, bare land, cultivated land, forest, grassland, permanent snow and ice, shrubland, tundra, water body, and wetland. The collected data will be used for validating GlobeLand30 (Kilsedar, Bratic, Molinari, Minghini, &amp; Brovelli, 2018). The data is licensed under the Open Database License (ODbL) v1.0 and can be downloaded within the application in JSON format. The application is currently available in eight languages: English, Italian, Arabic, Russian, Chinese, Portuguese, French and Spanish. The technologies used are the same as the cross-platform Via Regina application. As a result, it is available on Android, iOS, and web (https://landcover.como.polimi.it/collector/); and it supports display and query of the collected data. While reporting a POI, the application asks the land cover class of it, the user’s degree of certainty on the correctness of the stated class, photos in north, east, south and west directions, and the user’s comment. Three hands-on workshops were given to teach this application and various ways to validate GlobeLand30: the first on September 1, 2018 at the World Bank in Dar es Salaam, Tanzania (in conjunction with the FOSS4G 2018 conference); the second on September 3, 2018 at the Regional Centre for Mapping of Resources for Development (RCMRD) in Nairobi, Kenya; and the third on October 1, 2018 at the Delft University of Technology in Delft, Netherlands. The workshops, run by representatives of the project's principal investigators &amp;ndash; Politecnico di Milano (Italy) and the National Geomatics Center of China (China) &amp;ndash; were attended by a total of 100 people with a background in GIS and remote sensing. (Brovelli et al., 2018).</p><p>Nonetheless, there are no widely adopted cross-platform open-source solutions or systems for on-site surveys that address the problem of information silos: isolated databases, where the information is not adequately shared but rather remains sequestered within each system, which is an obstacle to using data mining to make productive use of data of multiple systems.</p><p> PSAB (Participatory Sensing App Builder) is a platform that provides an open-source and easy to use cross-platform solution for the creation of custom smartphone applications as well as web applications and catalog service for publishing the data and make them available to everyone. It takes advantage of established standards (like XLSForm for defining the structure of the form and DublinCore for exposing metadata) as well as less known yet effective solutions, like WQ (https://wq.io), a framework developed for building reusable software platforms for citizen science. These technologies have been merged, together with other software like Django, PyCSW, PostgreSQL, in a single solution, in order to assist the user during the entire process, from the definition of the form structure, to the creation of an ad-hoc application and the publication of the collected data, inside a flexible and open-source platform.</p><p> Users registered to PSAB are allowed to create a new application by filling a web form where they can upload their XLSForm files and submit the metadata describing the data to be collected. A new application for collecting data on the field is generated and accessible via web and Android (while iOS requires a particular setup), ready to be used online and offline. The creator of each application is also the administrator of it, which means he/she is allowed to add or ban users and modify or remove existing data. Data is automatically synchronized between all the users participating in the project.</p><p> In the presentation we will show the applications we developed, starting from the ODK-based ones and coming to the PSAB application builder, and our experience related to their usage.</p>

COVID-19 Pandemic resulted in social mobility and travel restrictions to contain the infection. It has been reported that there happened post-pandemic surge in the use of the internet and social media as people rely on it more often for entertainment, work, and learning purposes. It is also been used as an unhealthy coping strategy for pandemic related stress. The smartphone was found to be the most common gadget used for accessing internet-based services. Owing to the postural alterations related to the small screen size of smartphones, neck pain was reported very commonly among smartphone users. Neck pain among smartphone users is a public health concern needing immediate attention in the pandemic time. Many of the risk factors leading to neck pain among smartphone users are modifiable. The authors outline preventive strategies that are mostly self- regulated. The strategies recommended include reducing Smartphone usage time (Smartphone-Free Time, Smartphone-Free Zone), maintaining ideal posture (Focus Breaks, Mobility Breaks, How am I keeping my posture?, Hands-free alternatives), doing regular exercises, preparing and following an activity schedule, and inculcating healthy habits. References Sohrabi C, Alsafi Z, O’Neill N, Khan M, Kerwan A, Al-Jabir A, et al. World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19). Int J Surg 2020; 76: 71–6. https://doi.org/10.1016/j.ijsu.2020.02.034 Király O, Potenza MN, Stein DJ, King DL, Hodgins DC, Saunders JB, et al. Preventing problematic internet use during the COVID-19 pandemic: Consensus guidance. Compr Psychiatry 2020; 100:152180. https://doi.org/10.1016/j.comppsych.2020.152180 Sun Y, Li Y, Bao Y, Meng S, Sun Y, Schumann G, et al. Brief Report: Increased Addictive Internet and Substance Use Behavior During the COVID‐19 Pandemic in China. Am J Addict 2020 ;29(4):268–70. https://doi.org/10.1111/ajad.13066 Varga E. How does the Internet Influences the Readers’ Behavior. Procedia Manuf. 2020; 46:949–56. https://doi.org/10.1016/j.promfg.2020.05.013 Zhuang L, Wang L, Xu D, Wang Z, Liang R. Association between excessive smartphone use and cervical disc degeneration in young patients suffering from chronic neck pain. J Orthop Sci. 2020; https://doi.org/1016/j.jos.2020.02.009 Davey S, Davey A. Assessment of smartphone addiction in indian adolescents: a mixed method study by systematic-review and meta-analysis approach. Int J Prev Med.2014;5(12):1500–11. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25709785 Smetaniuk P. A preliminary investigation into the prevalence and prediction of problematic cell phone use. J Behav Addict 2014 Mar;3(1):41–53. https://doi.org/1556/JBA.3.2014.004 Lee H, Seo MJ, Choi TY. The Effect of Home-based Daily Journal Writing in Korean Adolescents with Smartphone Addiction. J Korean Med Sci. 2016;31(5):764. https://doi.org/3346/jkms.2016.31.5.764 Yu S, Sussman S. Does Smartphone Addiction Fall on a Continuum of Addictive Behaviors? Int J Environ Res Public Health.2020;17(2):422. https://doi.org/10.3390/ijerph17020422.10. Kwon M, Kim D-J, Cho H, Yang S. The smartphone addiction scale: development and validation of a short version for adolescents. PLoS One2013;8(12): e83558. https://doi.org/1371/journal.pone.0083558 Ding D, Li J. Smartphone Overuse – A Growing Public Health Issue. J Psychol Psychother.2017;07(289):1-3. https://doi.org/0.4172/2161-0487.1000289 Boumosleh JM, Jaalouk D. Depression, anxiety, and smartphone addiction in university students- A cross sectional study. PLoS One 2017;12(8): e0182239. https://doi.org/1371/journal.pone.0182239 Xie Y, Szeto G, Dai J. Prevalence and risk factors associated with musculoskeletal complaints among users of mobile handheld devices: A systematic review. Appl Ergon.2017 Mar;59:132–42. https://doi.org/1016/j.apergo.2016.08.020 Alsalameh AM, Harisi MJ, Alduayji MA, Almutham AA, Mahmood FM. Evaluating the relationship between smartphone addiction/overuse and musculoskeletal pain among medical students at Qassim University. J Fam Med Prim care. 2019;8(9):2953–9. https://doi.org/4103/jfmpc.jfmpc_665_19 Toh SH, Coenen P, Howie EK, Smith AJ, Mukherjee S, Mackey DA, et al. A prospective longitudinal study of mobile touch screen device use and musculoskeletal symptoms and visual health in adolescents. Appl Ergon. 2020; 85:103028. https://doi.org/1016/j.apergo.2019.103028 Lee S, Kang H, Shin G. Head flexion angle while using a smartphone. Ergonomics. 2015 Feb 17;58(2):220–6. https://doi.org/1080/00140139.2014.967311 Guan X, Fan G, Chen Z, Zeng Y, Zhang H, Hu A, et al. Gender difference in mobile phone use and the impact of digital device exposure on neck posture. Ergonomics. 2016;59(11):1453–61. https://doi.org/10.1080/00140139.2016.1147614 Han H, Shin G. Head flexion angle when web-browsing and texting using a smartphone while walking. Appl Ergon. 2019; 81:102884. https://doi.org/1016/j.apergo.2019.102884 Singla D, Veqar Z. Association between forward head, rounded shoulders, and increased thoracic kyphosis: a review of the literature. J Chiropr Med. 2017;16(3):220–9. https://doi.org/1016/j.jcm.2017.03.004 Park J-H, Kang S-Y, Lee S-G, Jeon H-S. The effects of smart phone gaming duration on muscle activation and spinal posture: Pilot study. Physiother Theory Pract. 2017;33(8):661–9. https://doi.org/10.1080/09593985.2017.1328716 Xie Y, Szeto GPY, Dai J, Madeleine P. A comparison of muscle activity in using touchscreen smartphone among young people with and without chronic neck–shoulder pain. Ergonomics. 2016;59(1):61–72. https://doi.org/10.1080/00140139.2015.1056237 Hansraj KK. Assessment of stresses in the cervical spine caused by posture and position of the head. Surg Technol Int. 2014; 25:277–9. Li W, Yang Y, Liu Z-H, Zhao Y-J, Zhang Q, Zhang L, et al. Progression of mental health services during the COVID-19 outbreak in China. Int J Biol Sci. 2020;16(10):1732–8. https://doi.org/7150/ijbs.45120 Namwongsa S, Puntumetakul R, Neubert MS, Boucaut R. Factors associated with neck disorders among university student smartphone users. Work. 2018;61(3):367–78. https://doi.org/3233/WOR-182819 Ko P-H, Hwang Y-H, Liang H-W. Influence of smartphone use styles on typing performance and biomechanical exposure. Ergonomics. 2016;59(6):821–8. https://doi.org/10.1080/00140139.2015.1088075

Introdução: A candidemia é uma das infecções nasocomiais mais frequentes a nível mundial e apresenta diferentes espécies de Candida envolvidas com o desenvolvimento dessa patologia. Objetivo: Este estudo analisou os aspectos epidemiológicos e as diferentes espécies de Candida associadas à candidemia. Material e Métodos: Uma revisão de literatura foi realizada, através da leitura de artigos científicos publicados nas bases de dados Pubmed e Scielo nos últimos cinco anos. Utilizou-se as seguintes combinações de descritores: Candidemia, Candidemia e Prevalência, Candidemia e Incidência, Candidemia e Candida. Resultados: A candidemia é a infecção fúngica mais hostil atualmente encontrada e prevalente nas populações estudadas. A população mais afetada são os recém-nascidos. Apresenta altas taxas de mortalidade e disseminação em várias partes do mundo. A nutrição parenteral, a administração de antibióticos de amplo espectro, hospitalização prolongada, cirurgia prévia e colonização por Candida sp são os principais fatores de risco relatados na literatura. Múltiplas espécies fúngicas estão associadas a essa condição, porém C. albicans é a mais predominante, seguida por C. parapsilosis e C. tropicalis. Conclusões: A Candidemia é uma patologia prevalente e apresenta alta incidência e morbimortalidade nas populações estudadas das diferentes partes do mundo. C. albicans é a espécie mais associada, seguida por C. parapsilosis e C. tropicalis. Descritores: Candidemia; Prevalência; Incidência; Candida. Referências Treviño-Rangel RJ, Peña-López CD, Hernández-Rodríguez PA, Beltrán-Santiago D, González GM. Association between Candida biofilm-forming bloodstream isolates and the clinical evolution in patients with candidemia: An observational nine-year single center study in Mexico. Rev Iberoam Micol. 2018;35(1):11-16. Kaur H, Chakrabarti A. Strategies to Reduce Mortality in Adult and Neonatal Candidemia in Developing Countries. J Fungi (Basel). 2017;3(3):41. Wu PF, Liu WL, Hsieh MH, Hii IM, Lee YL, Lin YT et al. Epidemiology and antifungal susceptibility of candidemia isolates of non-albicans Candida species from cancer patients. Emerg Microbes Infect. 2017;6(10):e87. Vasilyeva NV, Raush ER, Rudneva MV, Bogomolova TS, Taraskina AE, Fang Y et al. Etiology of invasive candidosis agents in Russia: a multicenter epidemiological survey. Front Med. 2018;12(1):84-91. Barchiesi F, Orsetti E, Osimani P, Catassi C, Santelli F, Manso E. Factors related to outcome of bloodstream infections due to Candida parapsilosis complex. BMC Infect Dis. 2016;16:387. Barchiesi F, Orsetti E, Mazzanti S, Trave F, Salvi A, Nitti C, Manso E. Candidemia in the elderly: What does it change? PLoS One. 2017;12(5):e0176576. Benedict K, Roy M, Kabbani S, Anderson EJ, Farley MM, Harb S et al. Neonatal and pediatric candidemia: results from population-based active laboratory surveillance in four US locations, 2009-2015. J Pediatric Infect Dis Soc. 2018;7(3):e78-e85. Bhattacharjee P. Epidemiology and antifungal susceptibility of Candida species in a tertiary care hospital, Kolkata, India. Curr Med Mycol. 2016;2(2):20-7. Breda GL, Tuon FF, Meis JF, Herkert PF, Hagen F, de Oliveira LZ, Dias VC, da Cunha CA, Queiroz-Telles F. Breakthrough candidemia after the introduction of broad spectrum antifungal agents: A 5-year retrospective study. Med Mycol. 2018;56(4):406-15 Caggiano G, Lovero G, De Giglio O, Barbuti G, Montagna O, Laforgia N et al. Candidemia in the Neonatal Intensive Care Unit: a retrospective, observational survey and analysis of literature Data. Biomed Res Int. 2017;2017:7901763. Fu J, Ding Y, Wei B, Wang L, Xu S, Qin P, Wei L, Jiang L. Epidemiology of Candida albicans and non-C.albicans of neonatal candidemia at a tertiary care hospital in western China. BMC Infect Dis. 2017;17(1):329. Guzzetti LB, Vescina CM, Gil MF, Gatti BM. Candidemias en pediatría: distribución de especies y sensibilidad a los antifúngicos [Candidemia in Pediatrics: Species distribution and antifungal susceptibility]. Rev Argent Microbiol. 2017;49(4):320-22. Kofteridis DP, Valachis A, Dimopoulou D, Andrianaki AM, Christidou A, Maraki S, Spernovasilis NA, Samonis G. Factors Influencing Non-albicans Candidemia: A Case-Case-Control Study. 2017; 182(7-8):665-72. Kubiak DW, Farmakiotis D, Arons V, Hollins RM, Rostas SE, Weiser LM et al. Utility of in-house fluconazole disk diffusion susceptibility testing in the treatment of candidemia. Diagn Microbiol Infect Dis. 2016;84(3):223-26. Li D, Zhang W, Zheng S, Ma Z, Zhang P, Liu Z. Surveillance study of candidemia in cancer patients in North China. Med Mycol. 2013;51(4):378-84. Li D, Xia R, Zhang Q, Bai C, Li Z, Zhang P. Evaluation of candidemia in epidemiology and risk factors among cancer patients in a cancer center of China: an 8-year case-control study. BMC Infect Dis. 2017;17(1):536. Lortholary O, Renaudat C, Sitbon K, Desnos-Ollivier M, Bretagne S, Dromer F; French Mycoses Study Group. The risk and clinical outcome of candidemia depending on underlying Intensive Care Med. 2017; 43(5):652-62. Lovero G, De Giglio O, Montagna O, Diella G, Divenuto F, Lopuzzo M, Rutigliano S, Laforgia N, Caggiano G, Montagna MT. Epidemiology of candidemia in neonatal intensive care units: a persistent public health problem. Ann Ig. 2016;28(4):282-87. Márquez F, Iturrieta I, Calvo M, Urrutia M, Godoy-Martínez P. Epidemiología y susceptibilidad antifúngica de especies causantes de candidemia en la ciudad de Valdivia, Chile [Epidemiology and antifungal susceptibility of species producing candidemia in Valdivia, Chile]. Rev Chilena Infectol. 2017;34(5):441-46. Pinhati HM, Casulari LA, Souza AC, Siqueira RA, Damasceno CM, Colombo AL. Outbreak of candidemia caused by fluconazole resistant Candida parapsilosis strains in an intensive care unit. BMC Infect Dis. 2016;16(1):433. Siri L, Legarraga P, García P, González T, Rabagliati R. Cambios clínicos y epidemiológicos de candidemias en pacientes adultos desde 2000 a 2013. Rev Chilena Infectol. 2017;34(1):19-26. Spiers R, Smyth B, Lamagni T, Rooney P, Dorgan E, Wyatt T et al. The epidemiology and management of candidemia in Northern Ireland during 2002-2011, including a 12-month enhanced case review. Med Mycol. 2019;57(1):23-9. Tiraboschi IN, Pozzi NC, Farías L, García S, Fernández NB. Epidemiología, especies, resistencia antifúngica y evolución de las candidemias en un hospital universitario de Buenos Aires, Argentina, durante 16 años [Epidemiology, species, antifungal resistance and outcome of candidemia in a university hospital in Buenos Aires, Argentina for 16 years]. 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The pandemic of COVID-19 has afflicted every individual and has initiated a cascade of directly or indirectly involved events in precipitating mental health issues. The human species is a wanderer and hunter-gatherer by nature, and physical social distancing and nationwide lockdown have confined an individual to physical isolation. The present review article was conceived to address psychosocial and other issues and their aetiology related to the current pandemic of COVID-19. The elderly age group has most suffered the wrath of SARS-CoV-2, and social isolation as a preventive measure may further induce mental health issues. Animal model studies have demonstrated an inappropriate interacting endogenous neurotransmitter milieu of dopamine, serotonin, glutamate, and opioids, induced by social isolation that could probably lead to observable phenomena of deviant psychosocial behavior. Conflicting and manipulated information related to COVID-19 on social media has also been recognized as a global threat. Psychological stress during the current pandemic in frontline health care workers, migrant workers, children, and adolescents is also a serious concern. Mental health issues in the current situation could also be induced by being quarantined, uncertainty in business, jobs, economy, hampered academic activities, increased screen time on social media, and domestic violence incidences. The gravity of mental health issues associated with the pandemic of COVID-19 should be identified at the earliest. Mental health organization dedicated to current and future pandemics should be established along with Government policies addressing psychological issues to prevent and treat mental health issues need to be developed. References World Health Organization (WHO) Coronavirus Disease (COVID-19) Dashboard. 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Rapid urbanization rates impact significantly on the nature of Land Cover patterns of the environment, which has been evident in the depletion of vegetal reserves and in general modifying the human climatic systems (Henderson, et al., 2017; Kumar, Masago, Mishra, & Fukushi, 2018; Luo and Lau, 2017). This study explores remote sensing classification technique and other auxiliary data to determine LULCC for a period of 50 years (1967-2016). The LULCC types identified were quantitatively evaluated using the change detection approach from results of maximum likelihood classification algorithm in GIS. Accuracy assessment results were evaluated and found to be between 56 to 98 percent of the LULC classification. The change detection analysis revealed change in the LULC types in Minna from 1976 to 2016. Built-up area increases from 74.82ha in 1976 to 116.58ha in 2016. Farmlands increased from 2.23 ha to 46.45ha and bared surface increases from 120.00ha to 161.31ha between 1976 to 2016 resulting to decline in vegetation, water body, and wetlands. The Decade of rapid urbanization was found to coincide with the period of increased Public Private Partnership Agreement (PPPA). Increase in farmlands was due to the adoption of urban agriculture which has influence on food security and the environmental sustainability. The observed increase in built up areas, farmlands and bare surfaces has substantially led to reduction in vegetation and water bodies. The oscillatory nature of water bodies LULCC which was not particularly consistent with the rates of urbanization also suggests that beyond the urbanization process, other factors may influence the LULCC of water bodies in urban settlements. Keywords: Minna, Niger State, Remote Sensing, Land Surface Characteristics References Akinrinmade, A., Ibrahim, K., & Abdurrahman, A. (2012). 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Three compounds were isolated from the rhizome part of Canna edulis for the first time including liquiritigenin, methyl caffeate and uracil. Their structures were elucidated by spectroscopic methods as MS and NMR. Keywords Canna edulis Ker Gawl, liquiritigenin, methyl caffeate, uracil. References [1] T. H. Vu, Q. U. Le, Edible Canna (Canna edulis Ker), A Potential Crop for Vietnam Food Industry, International Journal of Botany Studies, Vol. 4, No. 4, 2019, pp. 58–59.[2] N. Tanakar, The Utilization of Edible Canna Plants in Southeastern Asia and Southern China, Economic Botany, Vol. 58, No. 1, 2004, 112–114.[3] A. S. A. Snafi, Bioactive Components and Pharmacological Effects of Canna indica - an Overview, International Journal of Pharmacology and Toxicology, Vol. 5, No. 2, 2015, pp. 71–75.[4] X. J. Zhang, Z. W. Wang, Q. Mi, Phenolic Compounds from Canna edulis Ker Residue and Their Antioxidant Activity, LWT - Food Science Technology, Vol. 44, No. 10, 2011, pp. 2091–2096, https://doi.org/10.1016/j.lwt.2011.05.021. [5] F. Xie, S. Gong, W. Zhang, J. Wu, Z. Wang, Potential of Lignin from Canna edulis Ker Residue in The Inhibition of α-d-glucosidase: Kinetics and Interaction Mechanism Merging with Docking Simulation, International Journal of Biology and Macromolecules, Vol. 95, 2017, pp. 592–602, https://doi.org/10.1016/j.ijbiomac.2016.11.100.[6] J. Zhang, Z. W. Wang, Soluble Dietary Fiber from Canna edulis Ker By-product and Its Physicochemical Properties, Carbohydrates Polymers, Vol. 92, No. 1, 2013, pp. 289–296, http:/doi.org/10.1016/j.carbpol.2012.09.067.[7] T. M. H. Nguyen, H. L. Le, T. T. Ha, B. H. Bui, N. T. Le, V. H. Nguyen, T. V. A. Nguyen, Inhibitory Effect on Human Platelet Aggregation and Coagulation and Antioxidant Activity of Canna edulis Ker Gawl Rhizhomes and Its Secondary Metabolites, Journal of Ethnopharmacology, Vol. 263, 2020, pp. 113-136, https:/doi.org/10.1016/j.jep.2020.113136.[8] T. A. Y. Diaa, M. A. Ramada, A. A. Khalifa, Acetophenones, a Chalcone, a Chromone and Flavonoids from Pancratium Maritimum, Phytochemistry, Vol. 49, No. 8, pp. 1998, pp. 2579-2583, http:/doi.org/10.1016/S003109422(98)00429-4. [9] W. Koji, Y. Osanai, T. Imaizumi, S. Kanno, M. Takeshita, M. Ishikawa, Inhibitory Effect of The Alkyl Side Chain of Caffeic Acid Analogues on Lipopolysaccharide-induced Nitric Oxide Production in RAW264.7 Macrophages, Bioorganic Med. Chem., Vol. 16, No. 16, 2008, pp. 7795–7803, https:/doi.org/10.1016/j.bmc.2008.07.006.[10] C. Y. Wang, L. Han, K. Kang, C. L. Shao, Y. X. Wei, C. J. Zheng, H. S Guan, Secondary Metabolites From Green Algae Ulva Pertusa, Chemistry of Natural Compounds Vol. 46, No. 5, 2010, pp. 828-830.[11] C. T. Inh, N. T. H. Van, P. M. Quan, T. T. Q. Trang, T. A. Vien, N. T. Thuy, D. T. Thao, New Diterpenoid Isolated from Medicinal Plant Euphorbia tithymaloides (P.), Vietnam J. Chem., Vol. 54, 2016, pp. 274-279, https:/doi.org/10.15625/0866-7144.2016-00304 (in Vietnamese).[12] Q. Y. Li, H. Liang, B. Wang, Z. Z. Zhao, Chemical Constituents of Momordica charantia L, Yao Xue Xue Bao, Vol. 44, No. 9, 2009, pp. 1014-1018.[13] V. T. Diep, L. T. Loan, N. T. Thu, T. T. Ha, N. M. Khoi, N. H. Tuan, D. T. Ha, Triterpen, Flavonoid and Pyrimidine Compounds from The Aerial Parts of Dregea volubilis, Journal of Medicinal Materials, Vol. 24, No. 6, 2019, pp. 329-332.[14] H. M. Eid, D. Vallerand, A. Muhammad, T. Durst, P. S. Haddad, L. C. Martineau, Structural Constraints and the Importance of Lipophilicity for the Mitochondrial Uncoupling Activity of Naturally Occurring Caffeic Acid Esters with Potential for the Treatment of Insulin Resistance, Biochemical Pharmacology, Vol. 79, No. 3, 2010, pp. 444–454, https:/doi.org/10.1016/j.bcp.2009.08.026.[15] K. Takahashi, Y. Yoshioka, E. Kato, S. Katsuki, O. Iida, K. Hosokawa, J. Kawabata, Methyl Caffeate as a Glucosidase Inhibitor from Solanum Torvum fruits and the Activity of Related Compounds, Bioscience, Biotechnology and Biochemistry, Vol. 74, No. 4, 2010, pp. 741–745, https:/doi.org/10.1271/bbb.9087.[16] S. M. Fiuza, C. Gomes, L. J. Teixeira, M. T. G. D. Cruz, M. N. Cordeiro, N. Milhazes, F. Borges, M. P. Marques, Phenolic Acid Derivatives with Potential Anticancer Properties, a Structure-Activity Relationship Study Part 1: Methyl, Propyl and Octyl Esters of Caffeic and Gallic Acids, Bioorgan Med Chem, Vol. 12, No. 13, 2004, pp. 3581-3589, https:/doi.org/10.1016/j.bmc.2004.04.026.[17] S. P. Lee, G. Jun, E. Yoon, S. Park, C. Yang, Inhibitory Effect of Methyl Caffeate on Fos-Jun-DNA Complex Formation and Suppression of Cancer Cell Growth, Bulletin of Korean Chemical Society, Vol. 22, No. 10, 2001, pp. 1131-1135.

The journal is pleased to publish the abstracts of the six finalists of the 2020 Manufacturing and Service Operations Management Society’s student paper competition. The 2020 prize committee was chaired by Vishal Agrawal (Georgetown), Feryal Erhun (University of Cambridge), and Jun Li (University of Michigan). The judges were Adem Orsdemir, Antoine Desir, Anton Ovchinnikov, Anyan Qi, Arian Aflaki, Arzum Akkas, Ashish Kabra, Bin Hu, Bob Batt, Bora Keskin, Can Zhang, Carri Chan, Chloe Kim Glaeser, Daniel Lin, Eduard Calvo, Ekaterina Astashkina, Elena Belavina, Elodie Adida, Enis Kayış, Ersin Korpeoglu, Fabian Sting, Fang Liu, Fanyin Zheng, Fei Gao, Florin Ciocan, Gah-Yi Ban, Gizem Korpeoglu, Guihua Wang, Guillaume Roels, Guoming Lai, Hessam Bavafa, Hummy Song, Ioannis (Yannis) Stamatopoulos, Ioannis Bellos, Iris Wang, Itir Karaesmen, Jiankun Sun, Jiaru Bai, Jing Wu, Joann de Zegher, Joel Wooten, John Silberholz, Jose Guajardo, Kaitlin Daniels, Karen Zheng, Ken Moon, Kenan Arifoglu, Lennart Baardman, Leon Valdes, Lesley Meng, Linwei Xin, Luyi Gui, Luyi Yang, Mary Parkinson, Mazhar Arikan, Michael Freeman, Ming Hu, Morvarid Rahmani, Mumin Kurtulus, Nan Yang, Necati Tereyagoglu, Nektarios Oraiopoulos, Nikos Trichakis, Nil Karacaoglu, Nitin Bakshi, Niyazi Taneri, Nur Sunar, Olga Perdikaki, Ovunc Yilmaz, Ozan Candogan, Ozge Sahin, Panos Markou, Pascale Crama, Pengyi Shi, Pnina Feldman, Qiuping Yu, Renyu (Philip) Zhang, Robert Bray, Ruslan Momot, Ruxian Wang, Saed Alizamir, Safak Yucel, Samantha Keppler, Santiago Gallino, Serdar Simsek, Seyed Emadi, Shiliang (John) Cui, Shouqiang Wang, Simone Marinesi, So Yeon Chun, Song-Hee Kim, Soo-Haeng Cho, Soroush Saghafian, Stefanus Jasin, Suresh Muthulingam, Suvrat Dhanorkar, Tian Chan, Tim Kraft, Tom Tan, Tugce Martagan, Velibor Misic, Weiming Zhu, Xiaoshan Peng, Xiaoyang Long, Yasemin Limon, Yehua Wei, Yiangos Papanastasiou, Ying-Ju Chen, and Zumbul Atan.

This study evaluates the effects of traditional preparation on the total phenol content and in vitro antioxidant activity of Fallopia multiflora Thunb.. The experimental results show that the total phenol content calculated with gallic acid (GAE) of Fallopia multiflora Thunb. increased during preparation processing. The Fallopia multiflora Thunb. after preparation had a total phenol content of 22.73 ± 0.21 mg GAE/g, about 3% higher than the raw sample (22.03 ± 0.40 mg GAE/g). The preparation processing also significantly increased the antioxidant activity of Fallopia multiflora Thunb.. The concentration of extract, which could neutralize 50% of the free radicals generated from 2.2-diphenyl-1-picrylhydrazyl of medicinal materials, after processing was 53.71 ± 0.44 µg/ml, about 2.3 times lower when compared to raw pharmaceutical materials (124,38 ± 0,56 µg/ml). Keywords Fallopia multilflora Thunb., processing, antioxidant, total phenol, neutralized free radicals. References [1] P.X. Sinh, Traditional pharmacology, Medical Publishing House, Ha Noi, 2014, pp. 352-353 (in Vietnamese).[2] L. Lin, C. Qu, J. Ni, A novel method to analyze hepatotoxic components in Polygonum multiflorum using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry, Journal of hazardous materials 299 (2015) 249-259. https://doi.org/10.1016/j.jhazmat.2015.06.014[3] Y. Liu, Q. Wang, J. Yang, X. Guo, W. Liu, S. Ma, S. Li, Polygonum multiflorum Thunb.: a review on chemical analysis, processing mechanism, quality evaluation, and hepatotoxicity, Frontiers in pharmacology 9 (2018) 364. http://doi.org/10.3389 / fphar.2018.00364.[4] J. Huang, J.P. Zhang, J.Q. Bai, M.J. Wei, J. Zhang, Z.H. Huang, G.H. Qu, W. Xu, X.H. Qiu, Chemical profiles and metabolite study of raw and processed Polygoni Multiflori Radix in rats by UPLC-LTQ-Orbitrap MSn spectrometry, Chinese journal of natural medicines 16 (5) (2018) 375-400. http://doi.org/10.1016 / S1875-5364 (18) 30070-0.[5] L. Liang, J. Xu, W.W. Zhou, E. Brand, H.B. Chen, Z.Z. Zhao, Integrating targeted and untargeted metabolomics to investigate the processing chemistry of Polygoni Multiflori Radix, Frontiers in pharmacology 9 (2018) 934. http://doi.org/10.3389/fphar.2018.00934.[6] Ministry of Health, Vietnamese Pharmacopoeia V, Medical Publishing House, Ha Noi, part 2, 2018, pp 1180-1181 (in Vietnamese).[7] N.T.H. Ly, T.T. Thao, P.V. Truong, P.T. Thuong, Quality Evaluation of Fallopia multiflora in Vietnam Based on HPLC-FLD and Chemometrics, Natural Products Chemistry & Research 6(6) (2018) 1-7. http://doi.org/10.4172/2329-6836.1000346.[8] L. Lin, B. Ni, H. Lin, M. Zhang, X. Li, Xi. Yin, C. Qu, J. Ni, Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: a review, Journal of Ethnopharmacology 159 (2015) 158-183. https://doi.org/10.1016/j.jep.2014.11.009.[9] G.A. Bounda, Y.U. Feng, Review of clinical studies of Polygonum multiflorum Thunb. and its isolated bioactive compounds, Pharmacognosy research 7 (3) (2015) 225. http://doi.org/10.4103 / 0974-8490.157957.[10] M.P. Kähkönen, A.I. Hopia, H.J. Vuorela, J.P. Rauha, K. Pihlaja, T. S. Kujala, M.Heinonen, Antioxidant activity of plant extracts containing phenolic compounds, Journal of agricultural and food chemistry 47 (10) (1999) 3954-3962. http://doi.org/10.1021 / jf990146l.[11] H.H. Lin, A. L. Charles, C.W. Hsieh, Y. ChiLee, J.Y. Ciou, Antioxidant effects of 14 Chinese traditional medicinal herbs against human low-density lipoprotein oxidation, Journal of traditional and complementary medicine 5 (1) (2015) 51-55. https://doi.org/10.1016/j.jtcme.2014.10.001.

Introdução: O padrão ouro atual para detectar o RNA de SARS-CoV-2 é por reação em cadeia da polimerase em tempo real de transcrição reversa (RT-rtPCR) em swabs nasofaríngeos (NPS). Por esse motivo, a demanda pelos NPS aumentou e sua escassez se tornou uma realidade em muitos países. Com isso o uso da saliva se mostra uma alternativa promissora na triagem epidemiológica além de ser de fácil coleta e não invasiva. Objetivo: realizar uma revisão sistemática da literatura para avaliar o uso da saliva como um espécime alternativo para a detecção de SARS-CoV-2. Metodologia: A pesquisa sistemática foi realizada em sete bancos de dados (PubMed, Cochrane Library, Lilacs, Scielo, Web of Science, Scopus e Google Scholar) usando a variação dos termos de pesquisa (COVID-19 OR SARS-CoV-2 OR 2019-nCoV) AND "Saliva" no ano de 2020, recuperando 5480 publicações. Resultados: Após a leitura dos títulos e resumos, 411 textos foram conduzidos para leitura integral e 30 publicações foram consideradas para avaliação qualitativa do artigo. Conclusão: A saliva se apresenta um método alternativo eficaz para a detecção de SARS-CoV-2 e diagnóstico de COVID-19.Descritores: Infecções por Coronavírus; Betacoronavirus; Saliva; Diagnóstico.ReferênciasHuang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497-506.Wang L, Wang Y, Ye D, Liu Q. A review of the 2019 Novel Coronavirus (COVID-19) based on current evidence. J Antimicrob Agents 2020;105948.Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med 2020;382:727-733.Coronaviridae Study Group of the International Committee on Taxonomy of V. 2020. The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol. 2020;5:536-544.Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, et al. The incubation period of Coronavirus Disease 2019 (COVID-19) from publicly reported confirmed cases: estimation and application. Ann Intern Med. 2020;172:577-82.To KK, Tsang OT, Chik-Yan Yip C, Chan KH, Wu TC, Chan JMC, et al. Consistent detection of 2019 novel coronavirus in saliva. Clin Infect Dis. 2020;149:5734265.Xu R, Cui B, Duan X, Zhang P, Zhou X, Yuan Q. Saliva: potential diagnostic value and transmission of 2019-nCoV. Int J Oral Sci. 2020;12:11.Khurshid Z, Asiri FYI, Al Wadaani H. Human Saliva: Non-Invasive Fluid for Detecting Novel Coronavirus (2019-nCoV). Int J Environ Res Public Health. 2020;17.Khurshid Z, Zohaib S, Najeeb S, Zafar MS, Slowey PD, Almas K. Human Saliva Collection Devices for Proteomics: An Update. Int J Mol Sci. 2016;17.Principais itens para relatar Revisões sistemáticas e Meta-análises: A recomendação PRISMA. Epidemiol. E Serviços Saúde 2015;24:335–42.Abdul MSM, Fatima U, Khanna SS, Bhanot R, Sharma A, Srivastava AP. Oral Manifestations of Covid-19-Are they the introductory symptoms?. J Adv Dent Sci Res. 2020;8:5.Azzi L, Carcano G, Dalla Gasperina D, Sessa F, Maurino V, Baj A. Two cases of COVID-19 with positive salivary and negative pharyngeal or respiratory swabs at hospital discharge: A rising concern. Oral Dis. 2020;00:1-3.Azzi L, Carcano G, Gianfagna F, Grossi P, Dalla Gasperina D, Genoni A, et al. Saliva is a reliable tool to detect SARS-CoV-2. J Infect. 2020;81:45-50.Becker D, Sandoval E, Amin A, De Hoff P, Leonetti N, Lim YW, et al. Saliva is less sensitive than nasopharyngeal swabs for COVID-19 detection in the community setting. medRxiv. 2020;20092338.Braz-Silva PH, Pallos D, Giannecchini S, To KKW. SARS-CoV-2: What can saliva tell us?. Oral Dis. 2020;13365.Chan JFW, Yip CCY, To KKW, Tang THC, Wong SCY, Leung KH, et al. Improved molecular diagnosis of COVID-19 by the novel, highly sensitive and specific COVID-19-RdRp/Hel real-time reverse transcription-PCR assay validated in vitro and with clinical specimens. J Clin Microbiol. 2020;58:5.Chen L, Zhao J, Peng J, Li X, Deng X, Geng Z, et al. Detection of 2019-nCoV in saliva and characterization of oral symptoms in COVID-19 patients. Lancet. 2020;3556665.Cheng VC, Wong SC, Chen JH, Yip CC, Chuang VW, Tsang OT, et al. Escalating infection control response to the rapidly evolving epidemiology of the Coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 in Hong Kong. Infect Control Hosp Epidemiol. 2020;41:493-498.Han P, Ivanovski S. Saliva—Friend and Foe in the COVID-19 Outbreak. Diagn. 2020;10:290.Iwasaki S, Fujisawa S, Nakakubo S, Kamada K, Yamashita Y, Fukumoto T, et al. Comparison of SARS-CoV-2 detection in nasopharyngeal swab and saliva. J Infect. 2020;20:30349.Krajewska J, Krajewski W, Zub K, Zatoński T. COVID-19 in otolaryngologist practice: a review of current knowledge. Eur Arch Otorhinolaryngol. 2020;1-13.Lalli MA, Chen X, Langmade SJ, Fronick CC, Sawyer CS, Burcea LC, et al. Rapid and extraction-free detection of SARS-CoV-2 from saliva with colorimetric LAMP. medRxiv. 2020;7273276.Li X, Geng M, Peng Y, Meng L, Lu S. Molecular immune pathogenesis and diagnosis of COVID-19. J Pharm Anal. 2020;10:101-108.Li H, Liu SM, Yu XH, Tang SL, Tang CK. Coronavirus disease 2019 (COVID-19): current status and future perspective. Int J Antimicrob Agents. 2020;105951.McCormick-Baw C, Morgan K, Gaffney D, Cazares Y, Jaworski K, Byrd A, et al. Saliva as an Alternate Specimen Source for Detection of SARS-CoV-2 in Symptomatic Patients Using Cepheid Xpert Xpress SARS-CoV-2. J Clin Microbiol. 2020;01109-20.Pasomsub E, Watcharananan SP, Boonyawat K, Janchompoo P, Wongtabtim G, Suksuwan W, et al. Saliva sample as a non-invasive specimen for the diagnosis of coronavirus disease-2019 (COVID-19): a cross-sectional study. Clin Microbiol Infect. 2020;20302780.Sabino-Silva R, Jardim ACG, Siqueira WL. Coronavirus COVID-19 impacts to dentistry and potential salivary diagnosis. Clinical oral investigations. 2020;1-3.Sapkota D, Thapa SB, Hasséus B, Jensen JL. Saliva testing for COVID-19?. BDJ. 2020;228:658-659.Sharma S, Kumar V, Chawla A, Logani A. Rapid detection of SARS-CoV-2 in saliva: Can an endodontist take the lead in point-of-care COVID-19 testing?. Int Endod J. 2020;13317.Tang YW, Schmitz JE, Persing DH, Stratton CW. Laboratory Diagnosis of COVID-19: Current Issues and Challenges. J Clin Microbiol. 2020;58(6).Tatikonda SS, Reshu P, Hanish A, Konkati S, Madham S. A Review of Salivary Diagnostics and Its Potential Implication in Detection of Covid-19. Cureus. 2020;12(4).To KKW, Tsang OTY, Leung WS, Tam AR, Wu TC, Lung DC, et al. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study. Lancet Infect Dis. 2020;20:565-574.Vinayachandran D, Saravanakarthikeyan B. Salivary diagnostics in COVID-19: Future research implications. J Dent Sci. 2020;7177105.Williams E, Bond K, Zhang B, Putland M, Williamson DA. Saliva as a non-invasive specimen for detection of SARS-CoV-2. J Clin Microbiol. 2020;00776-20.Wyllie AL, Fournier J, Casanovas-Massana A, Campbell M, Tokuyama M, Vijayakumar P, et al. Saliva is more sensitive for SARS-CoV-2 detection in COVID-19 patients than nasopharyngeal swabs. Medrxiv. 2020;20067835.Yoon JG, Yoon J, Song JY, Yoon SY, Lim CS, Seong H, et al. Clinical Significance of a High SARS-CoV-2 Viral Load in the Saliva. J Korean Med Sci. 2020;35(20).Zheng S, Yu F, Fan J, Zou Q, Xie G, Yang X, et al. Saliva as a Diagnostic Specimen for SARS-CoV-2 by a PCR-Based Assay: A Diagnostic Validity Study. Lancet. 2020;3543605.Zhong F, Liang Y, Xu J, Chu M, Tang G, Hu F, et al. Continuously High Detection Sensitivity of Saliva, Viral Shedding in Salivary Glands and High Viral Load in Patients with COVID-19. Lancet. 2020;3576869.

This paper presents an analytical approach to postbuckling behaviors of functionally graded multilayer nanocomposite plates reinforced by a low content of graphene platelets (GPLs) using the first order shear deformation theory, stress function and von Karman-type nonlinear kinematics and include the effect of an initial geometric imperfection. The weight fraction of GPL nano fillers is assumed to be constant in each individual GPL-reinforced composite (GPLRC). The modified Halpin-Tsai micromechanics model that takes into account the GPL geometry effect is adopted to estimate the effective Young’s modulus of GPLRC layers. The plate is assumed to resting on Pasternak foundation model and subjected to mechanical and thermal loads. The results show the influences of the GPL distribution pattern, weight fraction, geometry, elastic foundations, mechanical and temperature loads on the postbuckling behaviors of FG multilayer GPLRC plates. Keywords: Postbuckling; Graphene nanocomposite plate; First order shear deformation plate theory. References [1] K.S. Novoselov, A.K. Geim, S.V. Morozov, D. Jiang, Y. Zhang, S.V. Dubonos, I.V. Grigorieva, A. Firsov, Electric filed effect in atomically thin carbon films, Science 306 (2004) 666–669. http://doi.org/ 10.1126/science.1102896.[2] K.S. Novoselov, D. Jiang, F. Schedin, T.J. Booth, V.V. Khotkevich, S.V. Morozov, A.K. Geim, Two-dimensional atomic crystals, Proceedings of the National Academy of Sciences of the United States of America 102 (2005) 10451–10453. https://doi.org/10.1073/pnas.0502848102.[3] C.D. Reddy, S. Rajendran, K.M. Liew, Equilibrium configuration and continuum elastic properties of finite sized graphene, Nanotechnology 17 (2006) 864-870. https://doi. org/10.1088/0957-4484/17/3/042.[4] C. Lee, X.D. Wei, J.W. Kysar, J. Hone, Measurement of the elastic properties and intrinsic strength of monolayer graphene, Science 321 (2008) 385–388. http://doi.org/10.1126/ science.1157996.[5] F. Scarpa, S. Adhikari, A.S. Phani, Effective elastic mechanical properties of single layer graphene sheets, Nanotechnology 20 (2009) 065709. https://doi.org/10.1088/0957-4484/20/6/ 065709.[6] Y.X. Xu, W.J. Hong, H. Bai, C. Li, G.Q. Shi, Strong and ductile poly(vinylalcohol)/graphene oxide composite films with a layered structure, Carbon 47 (2009) 3538–3543. https://doi.org/ 10.1016/j.carbon.2009.08.022.[7] J.R. Potts, D.R. Dreyer, C.W. Bielawski, R.S. Ruoff, Graphene-based polymer nanocomposites, Polymer 52 (2011) 5-25. https://doi.org/10.1016/j .polymer.2010.11.042.[8] T.K. Das, S. Prusty, Graphene-based polymer composites and their applications, Polymer-Plastics Technology and Engineering 52 (2013) 319-331. https://doi.org/10.1080/03602559.2012. 751410.[9] M. Song, J. Yang, S. Kitipornchai, W. Zhud, Buckling and postbuckling of biaxially compressed functionally graded multilayer graphene nanoplatelet-reinforced polymer composite plates, International Journal of Mechanical Sciences 131–132 (2017) 345–355. https://doi.org/10.1016/j.ijmecsci.2017.07.017.[10] H.S. Shen, Y. Xiang, F. Lin, D. Hui, Buckling and postbuckling of functionally graded graphene-reinforced composite laminated plates in thermal environments, Composites Part B 119 (2017) 67-78. https://doi.org/10.1016/j.compositesb.2017. 03.020.[11] H. Wu, S. Kitipornchai, J. Yang, Thermal buckling and postbuckling of functionally graded graphene nanocomposite plates, Materials and Design 132 (2017) 430–441. https://doi.org/10. 1016/j.matdes.2017.07.025.[12] J. Yang, H. Wu, S. Kitipornchai, Buckling and postbuckling of functionally graded multilayer graphene platelet-reinforced composite beams, Composite Structures 161 (2017) 111–118. https://doi.org/10.1016/j.compstruct.2016.11.048.[13] H.S. Shen, Y. Xiang, Y. Fan, Postbuckling of functionally graded graphene-reinforced composite laminated cylindrical panels under axial compression in thermal environments, International Journal of Mechanical Sciences 135 (2018) 398–409. https://doi.org/10.1016/j.ijme csci.2017.11.031.[14] M.D. Rasool, B. Kamran, Stability analysis of multifunctional smart sandwich plates with graphene nanocomposite and porous layers, International Journal of Mechanical Sciences 167 (2019) 105283. https://doi.org/10.1016/j.ijmecs ci.2019.105283.[15] J.J. Mao, W. Zhang, Buckling and post-buckling analyses of functionally graded graphene reinforced piezoelectric plate subjected to electric potential and axial forces, Composite Structures 216 (2019) 392–405. https://doi.org/10.1016/j. compstruct.2019.02.095.[16] P.H. Cong, N.D. Duc, New approach to investigate nonlinear dynamic response and vibration of functionally graded multilayer graphene nanocomposite plate on viscoelastic Pasternak medium in thermal environment, Acta Mechanica 229 (2018) 651-3670. https://doi.org/ 10.1007/s00707-018-2178-3.[17] N.D. Duc, N.D. Lam, T.Q. Quan, P.M. Quang, N.V. Quyen, Nonlinear post-buckling and vibration of 2D penta-graphene composite plates, Acta Mechanica (2019), https://doi.org/10. 1007/s00707-019-02546-0.[18] N.D. Duc, P.T. Lam, N.V. Quyen, V.D. Quang, Nonlinear Dynamic Response and Vibration of 2D Penta-graphene Composite Plates Resting on Elastic Foundation in Thermal Environments, VNU Journal of Science: Mathematics-Physics 35(3) (2019) 13-29. https:// doi.org/10.25073/2588-1124/vnumap. 4371.[19] J.N. Reddy, Mechanics of laminated composite plates and shells; theory and analysis, Boca Raton: CRC Press, 2004.[20] H.S. Shen, A two-step perturbation method in nonlinear analysis of beams, plates and shells, John Wiley & Sons Inc., 2013.

Apolipoprotein C3 (APOC3) plays an important role in regulating lipid levels. This study aimed to assess whether the polymorphism APOC3-rs2854116 is associated with lipid profiles in primary school children in Hanoi. A case-control study was designed including 161 cases with dyslipidemia and 406 controls without dyslipidemia. Genotype for APOC3-rs2854116 polymorphism was determined by the polymerase chain reaction and restriction fragment length polymorphism method (PCR-RFLP). The results showed that there were differences in the effect of APOC3-rs2854116 polymorphism to lipid profiles among children with dyslipidemia. In comparison with A/G and A/A carriers, the G/G carriers had the higher concentration of serum TC, TG, and LDL-C (P < 0.05). APOC3-rs2854116 polymorphism was related to hypercholesterolemia in children with the most appropriate genetic model being additive model. Increasing each of the G alleles increased the risk of hypercholesterolemia by 2.2 times (P = 0.005) after adjustment for age and sex. This relationship was almost unchanged after adjustment for obesity-related traits. The study suggested that the APOC3-rs2854116 polymorphism significantly associated with hypercholesterolemia in primary school children in Hanoi independent of obesity-related traits. Keywords APOC3, rs2854116, hypercholesterolemia, primary school children. References [1] A. Kawakami, M. Yoshida, Apolipoprotein CIII links dyslipidemia with atherosclerosis, Journal of atherosclerosis and thrombosis 16(1) (2009) 6-11. https://doi.org/10.5551/jat.e607.[2] D. Gaudet, D. Brisson, K. Tremblay, V.J. Alexander, W. Singleton, S.G. Hughes, J.L. Witztum, Targeting APOC3 in the familial Chylomicronemia syndrome, New England Journal of Medicine 371(23) (2014) 2200-2206. https://doi.org/10.1056/NEJMoa1400284.[3] P. Libby, Triglycerides on the rise: should we swap seats on the seesaw?, European heart journal 36 (2015) 774-776. https://doi.org/10.1093/eurheartj/ehu500.[4] W.W. Li, M.M. Dammerman, J.D. Smith, S. Metzger, J.L. Breslow, T. Leff, Common genetic variation in the promoter of the human apoC-III gene abolishes regulation by insulin and may contribute to hypertriglyceridemia, Journal of Clinical Investigation 96(6) (1995) 2601-2605. https://doi.org/10.1172/JCI118324.[5] C. Couillard, M.C. Vohl, J.C. Engert, I. Lemieux, A. Houde, N. Alméras, J. Bergeron, Effect of apoC-III gene polymorphisms on the lipoprotein-lipid profile of viscerally obese men, Journal of lipid research 44(5) (2003) 986-993. https://doi.org/10.1194/jlr.M300043-JLR200.[6] J. Dallongeville, A. Meirhaeghe, D. Cottel, J.C. Fruchart, P. Amouyel, N. Helbecque, Gender related association between genetic variations of APOC-III gene and lipid and lipoprotein variables in northern France, Atherosclerosis 150(1) (2000) 149-157. https://doi.org/10.1016/s0021-9150(99)00362-7.[7] C.A. Rocco, D. Mecikovsky, P. Aulicino., R. Bologna, L. Sen, A. Mangano, Hypercholesterolemia Is Associated with the Apolipoprotein C-III (APOC3) Genotype in Children Receiving HAART: An Eight-Year Retrospective Study, PLos One 7(7) (2012) e39678. https://doi.org/10.1371/journal.pone.0039678.[8] S. Li, Y. Yang, X. Ouyang, J. Shen, M. Zhou, Y.Y. Song, Associations of the APOC3 rs2854116 and rs2854117 polymorphisms with plasma APOC3 and lipid levels: a meta-analysis, Int J Clin Exp Med 9(8) (2016) 15972. http://www.ijcem.com/files/ijcem0025065.pdf[9] N.C. Khan, L.B. Mai, D.T.P. Ha, N.D. Minh, L.D. Tuyen, H.H Tue, Overweight, obesity and related association in adults aged 25-54 years, Nutrition status and intervention strategy in Vietnam (2007) 49-72. (in Vietnamese).[10] T.T. Mai, L.T. Hop, N.T. Lam, N.T. Xuan, Overweight, obesity and dyslipidemia in children aged 4-9 years in some primary schools of Hoan Kiem District, Hanoi. Journal of Food and Nutrition 9(3) (2013) 9-18. (in Vietnamese).[11] P.O. Kwiterovich, Recognition and management of dyslipidemia in children and adolescents, The Journal of clinical endocrinology and metabolism 93(11) (2008) 4200-4209. https://doi.org/10.1210/jc.2008-1270.[12] National Cholesterol Education Program, Report of the Expert Panel on Blood Cholesterol Levels in Children and Adolescents, Pediatrics 89(S) (1992) 525-584. https://pediatrics.aappublications.org/content/pediatrics/89/3/495.full.pdf.[13] T.G. Lohman, A.F. Roche, R. Martorell, Anthropometric standardization reference manual, Champaign, IL: Human Kinetics Book, UK (1988).[14] N.T.H. Hanh, P.T. Phuong, T.Q. Binh, APOC3 rs2854116 single nucleotide polymorphism in Hanoi primary school children, The 2nd National Scientific Conference on Biological Research and Teaching in Vietnam, Vietnam National University Publishing House (2016) 287-294.[15] X. Solé, E. Guinó, J. Valls, R. Iniesta, V. Monero, SNPStats: a web tool for the analysis of association studies, Bioinformatics 22(15) (2006) 1928-1929. https://doi.org/10.1093/bioinformatics/btl268.[16] R.L. Pollex, M.R. Ban, T.K. Young, P. Bjerregaard, S.S. Anand, S. Yusuf, M.W. Huff, Association between the-455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample, BMC medical genetics 8(1) (2007) 80-87. https://dx.doi.org/10.1186%2F1471-2350-8-80.[17] N.T.H. Hanh, B.T. Nhung, L.T. Hop, T.Q. Binh, Association of nutritional status, family and neonatal characteristics with hypertriglycemia in primary school children in Hanoi. VNU Journal of Science: Natural Sciences and Technology 31(4S) (2015) 94-101 (in Vietnamese).[18] N.T.H. Hạnh, B.T. Nhung, T.Q. Binh, L.T. Hop, Optimal model on association of some environmental factors with Hyperalphalipoproteinemia in primary school children in Hanoi. Second National Conference on study and education of biology in Vietnam VNU publishing house (2016) 295-303 (in Vietnamese).[19] N.T.H. Hanh, B.T. Nhung, L.T. Hop, T.Q. Binh, Relationship between some environmental factors and hyperbetalipoproteinemia in 6 - 11 year-old children in Hanoi, Journal of Science, Hanoi National University of Education 61(9) (2016) 185-192. https://doi.org/10.18173/2354-1059.2016-0072.[20] M. Larsson, E. Vorrsjö, P. Talmud, A. Lookene, G. Olivecrona, Apolipoproteins CI and C-III inhibit lipoprotein lipase activity by displacement of the enzyme from lipid droplets, Journal of Biological Chemistry 288(47) (2013) 33997-34008. https://doi.org/10.1074/jbc.M113.495366.[21] M. Miller, J. Rhyne, H. Chen, V. Beach, R. Ericson, K. Luthra, A. Misra, APOC3 promoter polymorphisms C-482T and T-455C are associated with the metabolic syndrome, Archives of medical research 38(4) (2007) 444-451. https://doi.org/10.1016/j.arcmed.2006.10.013.[22] E.D. França, J.G.B. Alves, M.H. Hutz, APOA1/C3/A4 gene cluster variability and lipid levels in Brazilian children, Brazilian journal of medical and biological research 38(4) (2005) 535-541. http://dx.doi.org/10.1590/S0100-879X2005000400006.[23] F. Sentinelli, S. Romeo, C. Maglio, M. Incani, M.A. Burza, F. Scano, M.G. Baroni, Lack of effect of apolipoprotein C3 polymorphisms on indices of liver steatosis, lipid profile and insulin resistance in obese Southern Europeans, Lipids in health and disease 10(1) (2011). http://doi.org/10.1186/1476-511X-10-9.

As the name suggests, the humanities is largely a study of the human condition, in which history sits as a discipline concerned with the past. Environmental history is a new field that brings together scholars from a range of disciplines to consider the changing relationships between humans and the environment over time. Critiques of anthropocentrism that place humans at the centre of the universe or make assessments through an exclusive human perspective provide a challenge to scholars to rethink our traditional biases against the nonhuman world. The movement towards nonhumanism or posthumanism, however, does not seem to have had much of an impression on history as a discipline. What would a nonhumanist history look like if we re-centred the historical narrative around pigs? There are histories of pigs as food (see for example, The Cambridge History of Food which has a chapter on “Hogs”). There are food histories that feature pork in terms of its relationship to multiethnic identity (such as Donna Gabaccia’s We Are What We Eat) and examples made of pigs to promote ethical eating (Singer). Pigs are central to arguments about dietary rules and what motivates them (Soler; Dolander). Ancient pig DNA has also been employed in studies on human migration and colonisation (Larson et al.; Durham University). Pigs are also widely used in a range of products that would surprise many of us. In 2008, Christien Meindertsma spent three years researching the products made from a single pig. Among some of the more unexpected results were: ammunition, medicine, photographic paper, heart valves, brakes, chewing gum, porcelain, cosmetics, cigarettes, hair conditioner and even bio diesel. Likewise, Fergus Henderson, who coined the term ‘nose to tail eating’, uses a pig on the front cover of the book of that name to suggest the extraordinary and numerous potential of pigs’ bodies. However, my intention here is not to pursue a discussion of how parts of their bodies are used, rather to consider a reorientation of the historical narrative to place pigs at the centre of stories of our co-evolution, in order to see what their history might say about humans and our relationships with them. This is underpinned by recognition of the inter-relationality of humans and animals. The relationships between wild boar and pigs with humans has been long and diverse. In a book exploring 10,000 years of interaction, Anton Ervynck and Peter Rowley-Conwy argue that pigs have been central to complex cultural developments in human societies and they played an important role in human migration patterns. The book is firmly grounded within the disciplines of zoology, anthropology and archaeology and contributes to an understanding of the complex and changing relationship humans have historically shared with wild boar and domestic pigs. Naturalist Lyall Watson also explores human/pig relationships in The Whole Hog. The insights these approaches offer for the discipline of history are valuable (although overlooked) but, more importantly, such scholarship also challenges a humanist perspective that credits humans exclusively with historical change and suggests, moreover, that we did it alone. Pigs occupy a special place in this history because of their likeness to humans, revealed in their use in transplant technology, as well as because of the iconic and paradoxical status they occupy in our lives. As Ervynck and Rowley-Conwy explain, “On the one hand, they are praised for their fecundity, their intelligence, and their ability to eat almost anything, but on the other hand, they are unfairly derided for their apparent slovenliness, unclean ways, and gluttonous behaviour” (1). Scientist Niamh O’Connell was struck by the human parallels in the complex social structures which rule the lives of pigs and people when she began a research project on pig behaviour at the Agricultural Research Institute at Hillsborough in County Down (Cassidy). According to O’Connell, pigs adopt different philosophies and lifestyle strategies to get the most out of their life. “What is interesting from a human perspective is that low-ranking animals tend to adopt one of two strategies,” she says. “You have got the animals who accept their station in life and then you have got the other ones that are continually trying to climb, and as a consequence, their life is very stressed” (qtd. in Cassidy). The closeness of pigs to humans is the justification for their use in numerous experiments. In the so-called ‘pig test’, code named ‘Priscilla’, for instance, over 700 pigs dressed in military uniforms were used to study the effects of nuclear testing at the Nevada (USA) test site in the 1950s. In When Species Meet, Donna Haraway draws attention to the ambiguities and contradictions promoted by the divide between animals and humans, and between nature and culture. There is an ethical and critical dimension to this critique of human exceptionalism—the view that “humanity alone is not [connected to the] spatial and temporal web of interspecies dependencies” (11). There is also that danger that any examination of our interdependencies may just satisfy a humanist preoccupation with self-reflection and self-reproduction. Given that pigs cannot speak, will they just become the raw material to reproduce the world in human’s own image? As Haraway explains: “Productionism is about man the tool-maker and -user, whose highest technical production is himself […] Blinded by the sun, in thrall to the father, reproduced in the sacred image of the same, his rewards is that he is self-born, an auto telic copy. That is the mythos of enlightenment and transcendence” (67). Jared Diamond acknowledges the mutualistic relationship between pigs and humans in Guns, Germs and Steel and the complex co-evolutionary path between humans and domesticated animals but his account is human-centric. Human’s relationships with pigs helped to shape human history and power relations and they spread across the world with human expansion. But questioning their utility as food and their enslavement to this cause was not part of the account. Pigs have no voice in the histories we write of them and so they can appear as passive objects in their own pasts. Traces of their pasts are available in humanity’s use of them in, for example, the sties built for them and the cooking implements used to prepare meals from them. Relics include bones and viruses, DNA sequences and land use patterns. Historians are used to dealing with subjects that cannot speak back, but they have usually left ample evidence of what they have said. In the process of writing, historians attempt to perform the miracle, as Curthoys and Docker have suggested, of restoration; bringing the people and places that existed in the past back to life (7). Writing about pigs should also attempt to bring the animal to life, to understand not just their past but also our own culture. In putting forward the idea of an alternative history that starts with pigs, I am aware of both the limits to such a proposal, and that most people’s only contact with pigs is through the meat they buy at the supermarket. Calls for a ban on intensive pig farming (RSPCA, ABC, AACT) might indeed have shocked people who imagine their dinner comes from the type of family farm featured in the movie Babe. Baby pigs in factory farms would have been killed a long time before the film’s sheep dog show (usually at 3 to 4 months of age). In fact, because baby pigs do grow so fast, 48 different pigs were used to film the role of the central character in Babe. While Babe himself may not have been aware of the relationship pigs generally have to humans, the other animals were very cognisant of their function. People eat pigs, even if they change the name of the form it takes in order to do so:Cat: You know, I probably shouldn’t say this, but I’m not sure if you realize how much the other animals are laughing at you for this sheep dog business. Babe: Why would they do that? Cat: Well, they say that you’ve forgotten that you’re a pig. Isn't that silly? Babe: What do you mean? Cat: You know, why pigs are here. Babe: Why are any of us here? Cat: Well, the cow’s here to be milked, the dogs are here to help the Boss's husband with the sheep, and I’m here to be beautiful and affectionate to the boss. Babe: Yes? Cat: [sighs softly] The fact is that pigs don’t have a purpose, just like ducks don’t have a purpose. Babe: [confused] Uh, I—I don’t, uh ... Cat: Alright, for your own sake, I’ll be blunt. Why do the Bosses keep ducks? To eat them. So why do the Bosses keep a pig? The fact is that animals don’t seem to have a purpose really do have a purpose. The Bosses have to eat. It’s probably the most noble purpose of all, when you come to think about it. Babe: They eat pigs? Cat: Pork, they call it—or bacon. They only call them pigs when they’re alive (Noonan). Babe’s transformation into a working pig to round up the sheep makes him more useful. Ferdinand the duck tried to do the same thing by crowing but was replaced by an alarm clock. This is a common theme in children’s stories, recalling Charlotte’s campaign to praise Wilbur the pig in order to persuade the farmer to let him live in E. B. White’s much loved children’s novel, Charlotte’s Web. Wilbur is “some pig”, “terrific”, “radiant” and “humble”. In 1948, four years before Charlotte’s Web, White had published an essay “Death of a Pig”, in which he fails to save a sick pig that he had bought in order to fatten up and butcher. Babe tried to present an alternative reality from a pig’s perspective, but the little pig was only spared because he was more useful alive than dead. We could all ask the question why are any of us here, but humans do not have to contemplate being eaten to justify their existence. The reputation pigs have for being filthy animals encourages distaste. In another movie, Pulp Fiction, Vincent opts for flavour, but Jules’ denial of pig’s personalities condemns them to insignificance:Vincent: Want some bacon? Jules: No man, I don’t eat pork. Vincent: Are you Jewish? Jules: Nah, I ain’t Jewish, I just don’t dig on swine, that’s all. Vincent: Why not? Jules: Pigs are filthy animals. I don’t eat filthy animals. Vincent: Bacon tastes gooood. Pork chops taste gooood. Jules: Hey, sewer rat may taste like pumpkin pie, but I’d never know ’cause I wouldn’t eat the filthy motherfucker. Pigs sleep and root in shit. That’s a filthy animal. I ain’t eat nothin’ that ain’t got sense enough to disregard its own feces [sic]. Vincent: How about a dog? Dogs eats its own feces. Jules: I don’t eat dog either. Vincent: Yeah, but do you consider a dog to be a filthy animal? Jules: I wouldn’t go so far as to call a dog filthy but they’re definitely dirty. But, a dog’s got personality. Personality goes a long way. Vincent: Ah, so by that rationale, if a pig had a better personality, he would cease to be a filthy animal. Is that true? Jules: Well we’d have to be talkin’ about one charming motherfuckin’ pig. I mean he’d have to be ten times more charmin’ than that Arnold on Green Acres, you know what I’m sayin’? In the 1960s television show Green Acres, Arnold was an exceptional pig who was allowed to do whatever he wanted. He was talented enough to write his own name and play the piano and his attempts at painting earned him the nickname “Porky Picasso”. These talents reflected values that are appreciated, and so he was. The term “pig” is, however, chiefly used a term of abuse, however, embodying traits we abhor—gluttony, obstinence, squealing, foraging, rooting, wallowing. Making a pig of yourself is rarely honoured. Making a pig of the humanities, however, could be a different story. As a historian I love to forage, although I use white gloves rather than a snout. I have rubbed my face and body on tree trunks in the service of forestry history and when the temperature rises I also enjoy wallowing, rolling from side to side rather than drawing a conclusion. More than this, however, pigs provide a valid means of understanding key historical transitions that define modern society. Significant themes in modern history—production, religion, the body, science, power, the national state, colonialism, gender, consumption, migration, memory—can all be understood through a history of our relationships with pigs. Pigs play an important role in everyday life, but their relationship to the economic, social, political and cultural matters discussed in general history texts—industrialisation, the growth of nation states, colonialism, feminism and so on—are generally ignored. However “natural” this place of pigs may seem, culture and tradition profoundly shape their history and their own contribution to those forces has been largely absent in history. What, then, would the contours of such a history that considered the intermeshing of humans and pigs look like? The intermeshing of pigs in early human history Agricultural economies based on domestic animals began independently in different parts of the world, facilitating increases in population and migration. Evidence for long-term genetic continuity between modern and ancient Chinese domestic pigs has been established by DNA sequences. Larson et al. have made an argument for five additional independent domestications of indigenous wild boar populations: in India, South East Asia and Taiwan, which they use to develop a picture of both pig evolution and the development and spread of early farmers in the Far East. Domestication itself involves transformation into something useful to animals. In the process, humans became transformed. The importance of the Fertile Crescent in human history has been well established. The area is attributed as the site for a series of developments that have defined human history—urbanisation, writing, empires, and civilisation. Those developments have been supported by innovations in food production and animal husbandry. Pig, goats, sheep and cows were all domesticated very early in the Fertile Crescent and remain four of the world’s most important domesticated mammals (Diamond 141). Another study of ancient pig DNA has concluded that the earliest domesticated pigs in Europe, believed to be descended from European wild boar, were introduced from the Middle East. The research, by archaeologists at Durham University, sheds new light on the colonisation of Europe by early farmers, who brought their animals with them. Keith Dobney explains:Many archaeologists believe that farming spread through the diffusion of ideas and cultural exchange, not with the direct migration of people. However, the discovery and analysis of ancient Middle Eastern pig remains across Europe reveals that although cultural exchange did happen, Europe was definitely colonised by Middle Eastern farmers. A combination of rising population and possible climate change in the ‘fertile crescent’, which put pressure on land and resources, made them look for new places to settle, plant their crops and breed their animals and so they rapidly spread west into Europe (ctd in ScienceDaily). Middle Eastern farmers colonised Europe with pigs and in the process transformed human history. Identity as a porcine theme Religious restrictions on the consumption of pigs come from the same area. Such restrictions exist in Jewish dietary laws (Kashrut) and in Muslim dietary laws (Halal). The basis of dietary laws has been the subject of much scholarship (Soler). Economic and health and hygiene factors have been used to explain the development of dietary laws historically. The significance of dietary laws, however, and the importance attached to them can be related to other purposes in defining and expressing religious and cultural identity. Dietary laws and their observance may have been an important factor in sustaining Jewish identity despite the dispersal of Jews in foreign lands since biblical times. In those situations, where a person eats in the home of someone who does not keep kosher, the lack of knowledge about your host’s ingredients and the food preparation techniques make it very difficult to keep kosher. Dietary laws require a certain amount of discipline and self-control, and the ability to make distinctions between right and wrong, good and evil, pure and defiled, the sacred and the profane, in everyday life, thus elevating eating into a religious act. Alternatively, people who eat anything are often subject to moral judgments that may also lead to social stigmatisation and discrimination. One of the most powerful and persuasive discourses influencing current thinking about health and bodies is the construction of an ‘obesity epidemic’, critiqued by a range of authors (see for example, Wright & Harwood). As omnivores who appear indiscriminate when it comes to food, pigs provide an image of uncontrolled eating, made visible by the body as a “virtual confessor”, to use Elizabeth Grosz’s term. In Fat Pig, a production by the Sydney Theatre Company in 2006, women are reduced to being either fat pigs or shrieking shallow women. Fatuosity, a blog by PhD student Jackie Wykes drawing on her research on fat and sexual subjectivity, provides a review of the play to describe the misogyny involved: “It leaves no options for women—you can either be a lovely person but a fat pig who will end up alone; or you can be a shrill bitch but beautiful, and end up with an equally obnoxious and shallow male counterpart”. The elision of the divide between women and pigs enacted by such imagery also creates openings for new modes of analysis and new practices of intervention that further challenge humanist histories. Such interventions need to make visible other power relations embedded in assumptions about identity politics. Following the lead of feminists and postcolonial theorists who have challenged the binary oppositions central to western ideology and hierarchical power relations, critical animal theorists have also called into question the essentialist and dualist assumptions underpinning our views of animals (Best). A pig history of the humanities might restore the central role that pigs have played in human history and evolution, beyond their exploitation as food. Humans have constructed their story of the nature of pigs to suit themselves in terms that are specieist, racist, patriarchal and colonialist, and failed to grasp the connections between the oppression of humans and other animals. The past and the ways it is constructed through history reflect and shape contemporary conditions. In this sense, the past has a powerful impact on the present, and the way this is re-told, therefore, also needs to be situated, historicised and problematicised. The examination of history and society from the standpoint of (nonhuman) animals offers new insights on our relationships in the past, but it might also provide an alternative history that restores their agency and contributes to a different kind of future. As the editor of Critical Animals Studies, Steve Best describes it: “This approach, as I define it, considers the interaction between human and nonhuman animals—past, present, and future—and the need for profound changes in the way humans define themselves and relate to other sentient species and to the natural world as a whole.” References ABC. “Changes to Pig Farming Proposed.” ABC News Online 22 May 2010. 10 Aug. 2010 http://www.abc.net.au/news/stories/2010/05/22/2906519.htm Against Animal Cruelty Tasmania. “Australia’s Intensive Pig Industry: The Intensive Pig Industry in Australia Has Much to Hide.” 10 Sep. 2010 http://www.aact.org.au/pig_industry.htm Babe. Dir. Chris Noonan. Universal Pictures, 1995. Best, Steven. “The Rise of Critical Animal Studies: Putting Theory into Action and Animal Liberation into Higher Education.” Journal for Critical Animal Studies 7.1 (2009): 9-53. Cassidy, Martin. “How Close are Pushy Pigs to Humans?”. BBC News Online 2005. 10 Sep. 2010 http://news.bbc.co.uk/2/hi/uk_news/northern_ireland/4482674.stmCurthoys, A., and Docker, J. “Time Eternity, Truth, and Death: History as Allegory.” Humanities Research 1 (1999) 10 Sep. 2010 http://www.anu.edu.au/hrc/publications/hr/hr_1_1999.phpDiamond, Jared. Guns, Germs and Steel: The Fates of Human Societies. New York: W. W. Norton, 1999. Dolader, Miguel-Àngel Motis. “Mediterranean Jewish Diet and Traditions in the Middle Ages”. Food: A Culinary History. Eds. Jean-Louis Flandrin and Massimo Montanari. Trans. Clarissa Botsford, Arthus Golhammer, Charles Lambert, Frances M. López-Morillas and Sylvia Stevens. New York: Columbia UP, 1999. 224-44. Durham University. “Chinese Pigs ‘Direct Descendants’ of First Domesticated Breeds.” ScienceDaily 20 Apr. 2010. 29 Aug. 2010 http://www.sciencedaily.com/releases/2010/04/100419150947.htm Gabaccia, Donna R. We Are What We Eat: Ethnic Food and the Making of Americans. Cambridge: Harvard University Press, 1998. Grosz, Elizabeth. Volatile Bodies: Toward a Corporeal Feminism. St Leonards: Allen & Unwin, 1994. Haraway, D. “The Promises of Monsters: A Regenerative Politics for Inappropriate/d Others.” The Haraway Reader. New York: Routledge, 2005. 63-124. Haraway, D. When Species Meet: Posthumanities. 3rd ed. London: University of Minnesota Press, 2008. Henderson, Fergus. Nose to Tail Eating: A Kind of British Cooking. London: Bloomsbury, 2004. Kiple, Kenneth F., Kriemhild Coneè Ornelas. Cambridge History of Food. Cambridge: Cambridge University Press, 2000. Larson, G., Ranran Liu, Xingbo Zhao, Jing Yuan, Dorian Fuller, Loukas Barton, Keith Dobney, Qipeng Fan, Zhiliang Gu, Xiao-Hui Liu, Yunbing Luo, Peng Lv, Leif Andersson, and Ning Li. “Patterns of East Asian Pig Domestication, Migration, and Turnover Revealed by Modern and Ancient DNA.” Proceedings of the National Academy of Sciences, United States 19 Apr. 2010. 10 Sep. 2010 http://www.pnas.org/cgi/content/full/0912264107/DCSupplemental Meindertsma, Christien. “PIG 05049. Kunsthal in Rotterdam.” 2008. 10 Sep. 2010 http://www.christienmeindertsma.com/index.php?/books/pig-05049Naess, A. “The Shallow and the Deep, Long-Range Ecology Movement.” Inquiry 16 (1973): 95-100. Needman, T. Fat Pig. Sydney Theatre Company. Oct. 2006. Noonan, Chris [director]. “Babe (1995) Memorable Quotes”. 10 Sep. 2010 http://www.imdb.com/title/tt0112431/quotes Plumwood, V. Feminism and the Mastery of Nature. London: Routledge, 1993. Pulp Fiction. Dir. Quentin Tarantino. Miramax, 1994. RSPCA Tasmania. “RSPCA Calls for Ban on Intensive Pig Farming.” 10 Sep. 2010 http://www.rspcatas.org.au/press-centre/rspca-calls-for-a-ban-on-intensive-pig-farming ScienceDaily. “Ancient Pig DNA Study Sheds New Light on Colonization of Europe by Early Farmers” 4 Sep. 2007. 10 Sep. 2010 http://www.sciencedaily.com/releases/2007/09/070903204822.htm Singer, Peter. “Down on the Family Farm ... or What Happened to Your Dinner When it was Still an Animal.” Animal Liberation 2nd ed. London: Jonathan Cape, 1990. 95-158. Soler, Jean. “Biblical Reasons: The Dietary Rules of the Ancient Hebrews.” Food: A Culinary History. Eds. Jean-Louis Flandrin and Massimo Montanari. Trans. Clarissa Botsford, Arthus Golhammer, Charles Lambert, Frances M. López-Morillas and Sylvia Stevens. New York: Columbia University Press, 1999. 46-54. Watson, Lyall. The Whole Hog: Exploring the Extraordinary Potential of Pigs. London: Profile, 2004. White, E. B. Essays of E. B. White. London: HarperCollins, 1979. White, E. B. Charlotte’s Web. London: HarperCollins, 2004. Wright, J., and V. Harwood. Eds. Biopolitics and the ‘Obesity Epidemic’. New York: Routledge, 2009. Wykes, J. Fatuosity 2010. 29 Aug. 2010 http://www.fatuosity.net

Introduction I am on the phone with a journalist discussing my research into anti-vaccination. As the conversation winds up, they ask a question I have come to expect: "how big do you think this is?" My answer is usually some version of the following: that we have no way of knowing. I and my fellow researchers can only see the information that is public or in the sunlight. How anti-vaccination information spreads through private networks is dark to us. It is private and necessarily so. This means that we cannot track how these conversations spread in the private or parochial spaces of Facebook, nor can we consider how they might extend into other modes of mediated communication. Modern communication is a complex and multiplatform accomplishment. Consider this: I am texting with my friend, I send her a selfie, in the same moment I hear a notification, she has DMed me a relevant Instagram post via that app. I move to Instagram and share another post in response; we continue our text message conversation there. Later in the day, I message her on Facebook Messenger while participating in a mutual WhatsApp group chat. The next day we Skype, and while we talk, we send links back and forth, which in hindsight are as clear as hieroglyphics before the Rosetta stone. I comment on her Twitter post, and we publicly converse back and forth briefly while other people like our posts. None of these instances are discrete conversational events, even though they occur on different platforms. They are iterations on the same themes, and the archival properties of social media and private messaging apps mean that neither of you forgets where you left off. The conversation slides not only between platforms and contexts but in and out of visibility. Digitally mediated conversation hums in the background of daily life (boring meetings, long commutes and bad dates) and expands our understanding of the temporal and sequential limits of conversation. In this article, I will explore digitally-mediated cross-platform conversation as a problem in two parts, and how we can understand it as part of the 'dark social'. Specifically, I want to draw attention to how 'dark' online spaces are part of our everyday communicative practices and are not necessarily synonymous with the illicit, illegal, or deviant. I argue that the private conversations we have online are also part of the dark social web, insofar as they are hidden from the public eye. When I think of dark social spaces, I think of what lies beneath the surface of murky waters, what hides behind in backstage areas, and the moments between platforms. In contrast, 'light' (or public) social spaces are often perceived as siloed. The boundaries between these platforms are artificially clean and do not appear to leak into other spaces. This article explores the dark and shadowed spaces of online conversation and considers how we might approach them as researchers. Conversations occur in the backchannels of social media platforms, in private messaging functions that are necessarily invisible to the researcher's gaze. These spaces are distinct from the social media activity analysed by Marwick and boyd. Their research examining teens' privacy strategies on social media highlights how social media posts that multiple audiences may view often hold encoded meanings. Social media posts are a distinct and separate category of activity from meditated conversations that occur one to one, or in smaller group chat settings. Second is the disjunction between social media platforms. Users spread their activity across any number of social media platforms, according to social and personal logics. However, these movements are difficult to capture; it is difficult to see in the dark. Platforms are not hermeneutically sealed off from each other, or the broader web. I argue that understanding how conversation moves between platforms and in the backstage spaces of platforms are two parts of the same dark social puzzle. Conversation Online Digital media have changed how we maintain our social connections across time and space. Social media environments offer new possibilities for communication and engagement as well as new avenues for control. Calls and texts can be ignored, and our phones are often used as shields. Busying ourselves with them can help us avoid unwanted face-to-face conversations. There are a number of critiques regarding the pressure of always-on contact, and a growing body of research that examines how users negotiate these demands. By examining group messaging, Mannell highlights how the boundaries of these chats are porous and flexible and mark a distinct communicative break from previous forms of mobile messaging, which were largely didactic. The advent of group chats has also led to an increasing complication of conversation boundaries. One group chat may have several strands of conversation sporadically re-engaged with over time. Manell's examination of group chats empirically illustrates the complexity of digitally-mediated conversations as they move across private, parochial, and public spaces in a way that is not necessarily temporally linear. Further research highlights the networked nature of digitally mediated interpersonal communication and how conversations sprawl across multiple platforms (Burchell). Couldry (16, 17) describes this complex web as the media manifold. This concept encompasses the networked platforms that comprise it and refers to its embeddedness in daily life. As we no longer “log on” to the internet to send and receive email, the manifold is both everywhere and nowhere; so too are our conversations. Gershon has described the ways we navigate the communicative affordances of these platforms as “media ideologies" which are the "beliefs, attitudes, and strategies about the media they [individuals] use" (391). Media ideologies also contain implicit assumptions about which platforms are best for delivering which kinds of messages. Similarly, Burchell argues that the relational ordering of available media technologies is "highly idiosyncratic" (418). Burchell contends that this idiosyncratic ordering is interdependent and relational, and that norms about what to do when are both assumed by individuals and learnt in their engagement with others (418). The influence of others allows us to adjust our practices, or as Burchell argues, "to attune and regulate one's own conduct … and facilitate engagement despite the diverse media practices of others" (418). In this model, individuals are constantly learning and renegotiating norms of conversation on a case by case, platform by platform basis. However, I argue that it is more illuminating to consider how we have collectively developed an implicit and unconscious set of norms and signals that govern our (collective) conduct, as digitally mediated conversation has become embedded in our daily lives. This is not to say that everyone has the same conversational skill level, but rather that we have developed a common toolbox for understanding the ebb and flow of digitally mediated conversations across platforms. However, these norms are implicit, and we only have a partial understanding of how they are socially achieved in digitally-mediated conversation. What Lies Beneath Most of what we do online is assumed not to be publicly visible. While companies like Facebook trace us across the web and peer into every nook and cranny of our private use patterns, researchers have remained focussed on what lies above in the light, not below, in the dark. This has meant an overwhelming focus on single platform studies that rely on the massification of data as a default measure for analysing sentiment and behaviour online. Sociologically, we know that what occurs in dark social spaces, or backstage, is just as important to social life as what happens in front of an audience (Goffman). Goffman's research uses the metaphor of the theatre to analyse how social life is accomplished as a performance. He highlights that (darkened) backstage spaces are those where we can relax, drop our front, and reveal parts of our (social) self that may be unpalatable to a broader audience. Simply, the public data accessible to researchers on social media are “trace data”, or “trace conversation”, from the places where conversations briefly leave (public) footprints and can be tracked and traced before vanishing again. Alternatively, we can visualise internet researchers as swabbing door handles for trace evidence, attempting to assemble a narrative out of a left-behind thread or a stray fingerprint. These public utterances, often scraped through API access, are only small parts of the richness of online conversation. Conversations weave across multiple platforms, yet single platforms are focussed on, bracketing off their leaky edges in favour of certainty. We know the social rules of platforms, but less about the rules between platforms, and in their darker spaces. Conversations briefly emerge into the light, only to disappear again. Without understanding how conversation is achieved and how it expands and contracts and weaves in and out of the present, we are only ever guessing about the social dynamics of mediated conversation as they shift between light, dark, and shadow spaces. Small things can cast large shadows; something that looms large may be deceptively small. Online they could be sociality distorted by disinformation campaigns or swarms of social bots. Capturing the Unseen: An Ethnomethodological Approach Not all data are measurable, computable, and controllable. There is uncertainty beyond what computational logics can achieve. Nooks and crannies of sociality exist beyond the purview of computable data. This suggests that we can apply pre-digital social research methods to capture these “below the surface” conversations and understand their logics. Sociologists have long understood that conversation is a social accomplishment. In the 1960s, sociologist Harvey Sacks developed conversation analysis as an ethnomethodological technique that seeks to understand how social life is accomplished in day-to-day conversation and micro-interactions. Conversation analysis is a detailed and systematic account of how naturally-occurring talk is socially ordered, and has been applied across a number of social contexts, including news interviews, judicial settings, suicide prevention hotlines, therapy sessions, as well as regular phone conversations (Kitzinger and Frith). Conversation analysis focusses on fine-grained detail, all of the little patterns of speech that make up a conversation; for example, the pauses, interruptions, self-corrections, false starts, and over-speaking. Often these too are hidden features of conversation, understood implicitly, but hovering on the edges of our social knowledge. One of the most interesting uses of conversational analysis is to understand refusal, that is, how we say 'no' as a social action. This body of research turns common-sense social knowledge – that saying no is socially difficult – into a systemic schema of social action. For instance, acceptance is easy to achieve; saying yes typically happens quickly and without hesitation. Acceptances are not qualified; a straightforward 'yes' is sufficient (Kitzinger and Frith). However, refusals are much more socially complex. Refusal is usually accomplished by apologies, compliments, and other palliative strategies that seek to cushion the blow of refusals. They are delayed and indirect conversational routes, indicating their status as a dispreferred social action, necessitating their accompaniment by excuses or explanations (Kitzinger and Frith). Research by Kitzinger and Frith, examining how women refuse sexual advances, illustrates that we all have a stock of common-sense knowledge about how refusals are typically achieved, which persists across various social contexts, including in our intimate relationships. Conversation analysis shows us how conversation is achieved and how we understand each other. To date, conversation analysis techniques have been applied to spoken conversation but not yet extended into text-based mediated conversation. I argue that we could apply insights from conversation analysis to understand the rules that govern digitally mediated conversation, how conversation moves in the spaces between platforms, and the rules that govern its emergence into public visibility. What rules shape the success of mediated communication? How can we understand it as a social achievement? When conversation analysis walks into the dark room it can be like turning on the light. How can we apply conversation analysis, usually concerned with the hidden aspects of plainly visible talk, to conversation in dark social spaces, across platforms and in private back channels? There is evidence that the norms of refusal, as highlighted by conversation analysis, are persistent across platforms, including in people's private digitally-mediated conversations. One of the ways in which we can identify these norms in action is by examining technology resistance. Relational communication via mobile device is pervasive (Hall and Baym). The concentration of digitally-mediated communication into smartphones means that conversational norms are constantly renegotiated, alongside expectations of relationship maintenance in voluntary social relationships like friendship (Hall and Baym). Mannell also explains that technology resistance can include lying by text message when explaining non-availability. These small, habitual, and often automatic lies are categorised as “butler lies” and are a polite way of achieving refusal in digitally mediated conversations that are analogous to how refusal is accomplished in face-to-face conversation. Refusals, rejections, and, by extension, unavailability appear to be accompanied by the palliative actions that help us achieve refusal in face-to-face conversation. Mannell identifies strategies such as “feeling ill” to explain non-availability without hurting others' feelings. Insights from conversation analysis suggest that on balance, it is likely that all parties involved in both the furnishing and acceptance of a butler lie understand that these are polite fabrications, much like the refusals in verbal conversation. Because of their invisibility, it is easy to assume that conversations in the dark social are chaotic and disorganised. However, there are tantalising hints that the reverse is true. Instead of arguing that individuals construct conversational norms on a case by case, platform by platform basis, I suggest that we now have a stock of common-sense social knowledge that we also apply to cross-platform mediated communication. In the spaces where gaps in this knowledge exist, Szabla and Blommaert argue that actors use existing norms of interactions and can navigate a range of interaction events even in online environments where we would expect to see a degree of context collapse and interactional disorganisation. Techniques of Detection How do we see in the dark? Some nascent research suggests a way forward that will help us understand the rhythms of cross-platform mediated conversation. Apps have been used to track participants' messaging and calling activities (Birnholtz, Davison, and Li). This research found a number of patterns that signal a user's attention or inattention, including response times and linguistic clues. Similarly, not-for-profit newsroom The Markup built a Facebook inspector called the citizen browser, a "standalone desktop application that was distributed to a panel of more than 1000 paid participants" (Mattu et al.). The application works by being connected to a participant's Facebook account and periodically capturing data from their Facebook feeds. The data is automatically deidentified but is still linked to the demographic information that participants provide about themselves, such as gender, race, location, and age. Applications like these point to how researchers might reliably collect interaction data from Facebook to glimpse into the hidden networks and interactions that drive conversation. User-focussed data collection methods also help us, as researchers, to sever our reliance on API access. API-reliant research is dependent on the largesse of social media companies for continued access and encourages research on the macro at the micro's expense. After all, social media and other digital platforms are partly constituted by the social acts of their users. Without speech acts that constitute mediated conversation, liking, sharing GIFs, and links, as well as the gaps and silences, digital platforms cease to exist. Digital platforms are not just archives of “big data”, but rather they are collections of speech and records of how our common-sense knowledge about how to communicate has stretched and expanded beyond face-to-face contexts. A Problem of Bots Ethnomethodological approaches have been critiqued as focussing too much on the small details of conversation, on nit-picking small details, and thus, as unable to comment on macro social issues of oppression and inequality (Kitzinger and Frith 311). However, understanding digitally-mediated conversation through the lens of talk-as-human-interaction may help us untangle our most pressing social problems across digital platforms. Extensive research examines platforms such as Twitter for “inauthentic” behaviour, primarily identifying which accounts are bots. Bots accounts are programmed Twitter accounts (for example) that automatically tweet information on political or contentious issues, while mimicking genuine engagement. Bots can reply to direct messages too; they converse with us as they are programmed to act as “humanly” as possible. Despite this, there are patterns of behaviour and engagement that distinguish programmed bot accounts, and a number of platforms are dedicated to their detection. However, bots are becoming increasingly sophisticated and better able to mimic “real” human engagement online. But there is as yet no systematic framework regarding what “real” digitally mediated conversation looks like. An ethnomethodological approach to understanding this would better equip platforms to understand inauthentic activity. As Yang and colleagues succinctly state, "a supervised machine learning tool is only as good as the data used for its training … even the most advanced [bot detection] algorithms will fail with outdated training datasets" (8). On the flipside, organisations are using chat bots to deliver cognitive behavioural therapy and assist people in moments of psychological distress. But the bots do not feel human; they reply instantly to any message sent. Some require responses in the form of emojis. The basis of therapy is talk. Understanding more accurately how naturally-occurring talk functions in online spaces could create more sensitive and genuinely therapeutic tools. Conclusion It is easy to forget that social media have largely mainstreamed over the last decade; in this decade, crucial social norms about how we converse online have developed. These norms allow us to navigate our conversations, with intimate friends and strangers alike across platforms, both in and out of public view, in ways that are often temporally non-sequential. Dark social spaces are a matter of intense marketing interest. Advertising firm Disruptive Advertising identified the very spaces that are the focus of this article as “dark social”: messaging apps, direct messaging, and native mobile apps facilitate user activity that is "not as easily controlled nor tracked". Dark social traffic continues to grow, yet our understanding of why, how, and for whom trails behind. To make sense of our social world, which is increasingly indistinguishable from online activity, we need to examine the spaces between and behind platforms, and how they co-mingle. Where are the spaces where the affordances of multiple platforms and technologies scrape against each other in uncomfortable ways? How do users achieve intelligible conversation not just because of affordances, but despite them? Focussing on micro-sociological encounters and conversations may also help us understand what could build a healthy online ecosystem. How are consensus and agreement achieved online? What are the persistent speech acts (or text acts) that signal when consensus is achieved? To begin where I started, to understand the scope and power of anti-vaccination sentiment, we need to understand how it is shared and discussed in dark social spaces, in messaging applications, and other backchannel spaces. Taking an ethnomethodological approach to these conversational interactions could also help us determine how misinformation is refused, accepted, and negotiated in mediated conversation. Focussing on “dark conversation” will help us more richly understand our social world and add much needed insight into some of our pressing social problems. References Burchell, Kenzie. 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