Academic literature on the topic 'West African ZIKV'

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Journal articles on the topic "West African ZIKV"

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Machmouchi, Dana, Marie-Pierre Courageot, Chaker El-Kalamouni, Alain Kohl, and Philippe Desprès. "Replication properties of a contemporary Zika virus from West Africa." PLOS Neglected Tropical Diseases 18, no. 7 (2024): e0012066. http://dx.doi.org/10.1371/journal.pntd.0012066.

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Zika virus (ZIKV) has become a global health problem over the past decade due to the extension of the geographic distribution of the Asian/American genotype. Recent epidemics of Asian/American ZIKV have been associated with developmental disorders in humans. There is mounting evidence that African ZIKV may be associated with increased fetal pathogenicity necessitating to pay a greater attention towards currently circulating viral strains in sub-Saharan Africa. Here, we generated an infectious molecular clone GUINEA-18 of a recently transmitted human ZIKV isolate from West Africa, ZIKV-15555. T
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Machmouchi, Dana, Marie-Pierre Courageot, Eva Ogire, et al. "The NS1 protein of contemporary West African Zika virus potentiates viral replication and reduces innate immune activation." PLOS Neglected Tropical Diseases 18, no. 8 (2024): e0012146. http://dx.doi.org/10.1371/journal.pntd.0012146.

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Mosquito-borne Zika virus (ZIKV) from sub-Saharan Africa has recently gained attention due to its epidemic potential and its capacity to be highly teratogenic. To improve our knowledge on currently circulating strains of African ZIKV, we conducted protein sequence alignment and identified contemporary West Africa NS1 (NS1CWA) protein as a highly conserved viral protein. Comparison of NS1CWA with the NS1 of the historical African ZIKV strain MR766 (NS1MR766), revealed seven amino acid substitutions. The effects of NS1 mutations on protein expression, virus replication, and innate immune activat
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Rawlinson, William. "Pregnancy, the placenta and Zika virus (ZIKV) infection." Microbiology Australia 37, no. 4 (2016): 170. http://dx.doi.org/10.1071/ma16057.

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Zika virus (ZIKV) infections have been recognised in Africa and Asia since 1940. The virus is in the family Flaviviridae and genus Flavivirus, along with Dengue, Japanese encephalitis virus, Tick borne encephalitis, West Nile virus, and Yellow fever virus. These viruses share biological characteristics of an envelope, icosahedral nucleocapsid, and a non-segmented, positive sense, single-strand RNA genome of ~10kb encoding three structural proteins (capsid C pre-membrane/membrane PrM/M, envelope E), and seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5). ZIKV has three kno
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Rose, Noah H., Stéphanie Dabo, Silvânia da Veiga Leal, et al. "Enhanced mosquito vectorial capacity underlies the Cape Verde Zika epidemic." PLOS Biology 20, no. 10 (2022): e3001864. http://dx.doi.org/10.1371/journal.pbio.3001864.

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The explosive emergence of Zika virus (ZIKV) across the Pacific and Americas since 2007 was associated with hundreds of thousands of human cases and severe outcomes, including congenital microcephaly caused by ZIKV infection during pregnancy. Although ZIKV was first isolated in Uganda, Africa has so far been exempt from large-scale ZIKV epidemics, despite widespread susceptibility among African human populations. A possible explanation for this pattern is natural variation among populations of the primary vector of ZIKV, the mosquito Aedes aegypti. Globally invasive populations of Ae. aegypti
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Park, Jooyeon, Jinhwa Jang, and Insung Ahn. "Comparison of Genetic Variations in Zika Virus Isolated From Different Geographic Regions." International Journal of Healthcare Information Systems and Informatics 14, no. 3 (2019): 29–39. http://dx.doi.org/10.4018/ijhisi.2019070103.

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The Zika virus (ZIKV) belongs to the genus Flavivirus, together with Dengue virus, yellow fever virus, and West Nile virus. The virus, which was first found in Africa in 1947, has spread across the world owing to a lack of effective drugs or vaccines. The complete genome sequence of ZIKV is now available; it includes three structural and seven non-structure genes arranged in the order of capsid, pre-membrane, envelope, NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5. Two geographically distinct lineages are known, i.e., Asian and African, but ZIKV exhibits differences in clinical progression among r
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Majumder, Maimuna S., Rosanna Hess, Ratchneewan Ross, and Helen Piontkivska. "Seasonality of birth defects in West Africa: could congenital Zika syndrome be to blame?" F1000Research 7 (February 7, 2018): 159. http://dx.doi.org/10.12688/f1000research.13858.1.

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The link between Zika virus infection during pregnancy and microcephaly and other neurodevelopmental defects in infants, referred to as congenital Zika syndrome (CZS), was recently discovered. One key question that remains is whether such neurodevelopmental abnormalities are limited to the recently evolved Asiatic ZIKV strains or if they can also be induced by endemic African strains. Thus, we examined birth registries from one particular hospital from a country in West Africa, where ZIKV is endemic. Results showed a seasonal pattern of birth defects that is consistent with potential CZS, whic
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Majumder, Maimuna S., Rosanna Hess, Ratchneewan Ross, and Helen Piontkivska. "Seasonality of birth defects in West Africa: could congenital Zika syndrome be to blame?" F1000Research 7 (July 19, 2018): 159. http://dx.doi.org/10.12688/f1000research.13858.2.

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The link between Zika virus infection during pregnancy and microcephaly and other neurodevelopmental defects in infants, referred to as congenital Zika syndrome (CZS), was recently discovered. One key question that remains is whether such neurodevelopmental abnormalities are limited to the recently evolved Asiatic ZIKV strains or if they can also be induced by endemic African strains. Thus, we examined birth registries from one particular hospital from a country in West Africa, where ZIKV is endemic. Results showed a seasonal pattern of birth defects that is consistent with potential CZS, whic
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Bayandin, Roman B., Marat T. Makenov, Sanaba Boumbaly, et al. "The First Case of Zika Virus Disease in Guinea: Description, Virus Isolation, Sequencing, and Seroprevalence in Local Population." Viruses 15, no. 8 (2023): 1620. http://dx.doi.org/10.3390/v15081620.

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The Zika virus (ZIKV) is a widespread mosquito-borne pathogen. Phylogenetically, two lineages of ZIKV are distinguished: African and Asian–American. The latter became the cause of the 2015–2016 pandemic, with severe consequences for newborns. In West African countries, the African lineage was found, but there is evidence of the emergence of the Asian–American lineage in Cape Verde and Angola. This highlights the need to not only monitor ZIKV but also sequence the isolates. In this article, we present a case report of Zika fever in a pregnant woman from Guinea identified in 2018. Viral RNA was
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Dabo, Stéphanie, Annabelle Henrion-Lacritick, Alicia Lecuyer, et al. "Extensive variation and strain-specificity in dengue virus susceptibility among African Aedes aegypti populations." PLOS Neglected Tropical Diseases 18, no. 3 (2024): e0011862. http://dx.doi.org/10.1371/journal.pntd.0011862.

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African populations of the mosquito Aedes aegypti are usually considered less susceptible to infection by human-pathogenic flaviviruses than globally invasive populations found outside Africa. Although this contrast has been well documented for Zika virus (ZIKV), it is unclear to what extent it is true for dengue virus (DENV), the most prevalent flavivirus of humans. Addressing this question is complicated by substantial genetic diversity among DENV strains, most notably in the form of four genetic types (DENV1 to DENV4), that can lead to genetically specific interactions with mosquito populat
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Venkateswaran, Neeraja, Jawad Sarwar, Nishnath Parameswaran, et al. "Development and testing of a novel multiplex serodiagnostic assay for Zika and other arboviruses." Journal of Immunology 198, no. 1_Supplement (2017): 81.26. http://dx.doi.org/10.4049/jimmunol.198.supp.81.26.

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Abstract Human immunoglobulin (IgM) antibody capture enzyme linked immunosorbent assay (MAC-ELISA) is recommended by US Centers for Disease Control (CDC) to detect the Zika Virus (ZIKV) infection in samples collected after few days of the onset of disease. However, the cross-reactivity of IgM and immunoglobulin G (IgG) antibodies to ZIKV with dengue virus (DENV), West Nile virus (WNV), yellow fever virus (YFV) and some other related flaviviruses poses a significant challenge for an accurate detection of ZIKV infection in a singleplex serological assay. To overcome these challenges we developed
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Dissertations / Theses on the topic "West African ZIKV"

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Machmouchi, Dana. "Exploring the Pathogenic Mechanisms of West African Zika Virus : viral Replication and Host Interaction." Electronic Thesis or Diss., La Réunion, 2024. https://elgebar.univ-reunion.fr/login?url=http://thesesenligne.univ.run/24_14_D_MACHMOUCHI.pdf.

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Le virus Zika (ZIKV), historiquement limité à l'Afrique et à l'Asie, est devenu une préoccupation mondiale majeure, surtout après les épidémies récentes dans les Amériques associées à des malformations congénitales graves et des troubles neurologiques. Bien que la recherche se soit principalement concentrée sur le génotype asiatique/américain, des preuves croissantes montrent que les souches africaines du ZIKV pourraient également représenter une menace sévère, notamment en termes de pathogénicité fœtale. Cette thèse vise à améliorer notre compréhension des mécanismes moléculaires de la pathog
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Marchi, Serena. "Seroepidemiological study of Zika virus in selected West African countries between 2007 and 2012." Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1071228.

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Zika virus is a flavivirus transmitted by mosquitoes of the Aedes genus, isolated for the first time in Uganda in 1947 and usually associated with a mild disease clinically similar to other arbovirosis, such as Dengue and Chikungunya fevers. Few cases of infection were reported until 2007, when an outbreak occurred in Micronesia, followed by a large epidemic in French Polynesia and the Americas. During its emergence, Zika virus has been associated with more severe clinical manifestations, including neurological sequelae and congenital defects such as microcephaly. Before the recent spread, ser
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Book chapters on the topic "West African ZIKV"

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Diallo, Diawo, Alioune Gaye, Ibrahima Dia, Scott Weaver, and Mawlouth Diallo. "Zika Virus Studies in West Africa." In History of Arbovirology: Memories from the Field. Springer Nature Switzerland, 2023. http://dx.doi.org/10.1007/978-3-031-22003-6_18.

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Barrera, Roberto. "3. Aedes Transmitted Virus (ATV) Cycles." In Surveillance and Control of Dengue Vectors in the United States and Territories. Open Book Publishers, 2025. https://doi.org/10.11647/obp.0472.03.

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This chapter elucidates the distinct transmission pathways of dengue, chikungunya, and Zika viruses. It differentiates between enzootic cycles, primarily occurring in the forests of Southeast Asia and West Africa, involving sylvatic Aedes mosquitoes and nonhuman primates. Humans can become infected through bridge vectors like Ae. albopictus and Ae. furcifer in fringe-forest or rural areas. Notably, enzootic cycles of DENV are not evident in the Americas. The chapter then details the urban cycle, which is similar for all ATVs. In this cycle, domestic or peri-domestic Aedes mosquitoes transmit t
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Zhou, Xiao-Nong, Xiaokui Guo, and Xiaoxi Zhang. "Executive Summary." In Global One Health Index Report 2022. Springer Nature Singapore, 2025. https://doi.org/10.1007/978-981-97-4824-2_1.

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AbstractIn the last two decades, the globe has faced numerous significant public health crises triggered by zoonotic diseases. Notable instances include the severe acute respiratory syndrome (SARS) outbreak from 2002 to 2004, the Ebola virus epidemic in West Africa between 2013 and 2016, the spread of the Zika virus in the Americas from 2015 to 2016, and the COVID-19 pandemic starting in 2019. These events underscore the pressing need for a holistic, integrated approach to address these health threats. The global One Health index (GOHI) was introduced to meet this need, emphasizing a collabora
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Ashley, Elizabeth, Caryn Bern, Margaret Borok, et al. "Multisystem diseases and infections." In Oxford Handbook of Tropical Medicine 5e. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780198810858.003.0017.

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Differential diagnosis of fevers?, Fever without localizing features?, Sepsis?, Cancer?, General rules of cancer management?, Rheumatoid arthritis?, Osteoarthritis?, Systemic lupus erythematosus?, Typhoid and paratyphoid fevers?, Rickettsioses?, Bartonella?, Ehrlichia?, Coxiella?, Relapsing fevers?, Leptospirosis?, Brucellosis?, Plague?, Melioidosis?, Anthrax?, African trypanosomiasis?, American trypanosomiasis?, Visceral leishmaniasis (kala-azar)?, Infectious mononucleosis?, Measles?, Arboviruses and zoonotic haemorrhagic fever viruses , Ebola and Marburg virus diseases, Crimean-Congo haemorr
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Eccleston-Turner, Mark, and Clare Wenham. "Case Studies on the PHEIC Declaration." In Declaring a Public Health Emergency of International Concern. Policy Press, 2021. http://dx.doi.org/10.1332/policypress/9781529219333.003.0004.

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This chapter analyses the empirical examples of each PHEIC which has been declared, to understand the application of the legal criteria and political considerations. Starting with H1N1, and considering polio; Ebola in West-Africa; Zika; Ebola in DRC; and COVID-19 – for each outbreak we consider the background to the epidemic, the PHEIC decision making offered by supporting documentation; the temporary recommendations suggested by WHO; and further additional reflections as to the PHEIC process and utilisation.
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Oxford, John, Paul Kellam, and Leslie Collier. "Flaviviruses: yellow fever, dengue fever, and hepatitis C." In Human Virology. Oxford University Press, 2016. http://dx.doi.org/10.1093/hesc/9780198714682.003.0012.

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This chapter focuses on flaviviruses and notes that there are at least 70 serotypes of flavivirus. The molecular clock analysis dates the sojourn of these viruses from 10 to 100,000 years. The prototype virus of this family causes yellow fever (YF), which is a classic disease of antiquity, and the application of the term ‘white man’s grave’ to West Africa resulted from its impact on colonizers. The chapter refers to Carlos Finlay, who viewed the mosquito as the source and scourge of YF, but this was not proven until the volunteer experiments coordinated by Walter Reed in 1900. Other medically
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Hushie, Martin, Rita Suhuyini Salifu, and Iddrisu Seidu. "Strengthening International Health Security by Embedding the Role of Civil Society Organizations in National Health Systems: Lessons from the 2014–2016 West Africa Ebola Response." In Contemporary Developments and Perspectives in International Health Security - Volume 1. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.93333.

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Following the recent global health crises, such as the 2014 Ebola and 2016 ZIKA outbreaks, the international health community’s ability to deal with such threats has been debated. Amid discussions of how international health security (IHS) and related national health systems should and could be strengthened, the potential of harnessing the role of civil society organizations (CSOs) for more effective responses has been frequently raised. Such participation is often based on the notion that CSOs by their grassroots presence can more effectively help to address health security and health systems
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Hushie, Martin, Rita Suhuyini Salifu, and Iddrisu Seidu. "Strengthening International Health Security by Embedding the Role of Civil Society Organizations in National Health Systems: Lessons from the 2014–2016 West Africa Ebola Response." In Contemporary Developments and Perspectives in International Health Security - Volume 1. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.93333.

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Following the recent global health crises, such as the 2014 Ebola and 2016 ZIKA outbreaks, the international health community’s ability to deal with such threats has been debated. Amid discussions of how international health security (IHS) and related national health systems should and could be strengthened, the potential of harnessing the role of civil society organizations (CSOs) for more effective responses has been frequently raised. Such participation is often based on the notion that CSOs by their grassroots presence can more effectively help to address health security and health systems
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