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Journal articles on the topic 'Wet granulation technique'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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1

Zarekar Shivani Gulab, Raykar Sonali Dattu Zende Gauri Sampat, and Puranik Aboli K and Sanjay J. Ingle. "A review on the wet granulation technique and its modules." World Journal of Biology Pharmacy and Health Sciences 20, no. 2 (2024): 113–24. http://dx.doi.org/10.30574/wjbphs.2024.20.2.0836.

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Wet granulation is a processes that involves adding a liquid to a powder to create granule of a desired size and shape. Its used in many fields, including pharmaceutical, neutraceutical and zootechnics to improve the flowbility, compressibility, and dosage of powders. Their are different technique of wet granulation. Low shear wet granulation, which is a form of wet granulation, is an important unit operation in the pharmaceutical, detergent and food industries. The granulation mechanism for wet granulation include wetting and nucleation, consolidation and growth and attrition and breakage. Hi
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V., B. Khot* D.A. Bhagwat J. I. D'Souza S. S. Shelake S. V. Patil. "OPTIMIZATION OF GRANULATION TECHNIQUES FOR DEVELOPMENT OF TABLET DOSAGE FORM." Indo American Journal of Pharmaceutical Sciences 04, no. 12 (2017): 4626–39. https://doi.org/10.5281/zenodo.1123244.

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The purpose of this study was to optimize the best granulation techniques for development of tablet dosage form. The present study explains comparative study of different wet granulation techniques including Planetary mixer granulation, Rapid mixer granulation, Fluid bed granulation with Direct compression method. Similar formulations were used to evaluate Planetary mixer granulation, Rapid mixer granulation and Fluid bed granulation method. The granules prepared by different techniques were evaluated for particle size distribution, porosity, spherisity, bulk density, flow property and compres
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Souza, Tatiane Pereira de, José Luiz Gómez-Amoza, Ramón Martínez Pacheco, and Pedro Ros Petrovick. "Development of granules from Phyllanthus niruri spray-dried extract." Brazilian Journal of Pharmaceutical Sciences 45, no. 4 (2009): 669–75. http://dx.doi.org/10.1590/s1984-82502009000400009.

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The aim of this study was to develop granules from Phyllanthus niruri spray-dried extract using dry and wet granulation and to assess techniques to enable the production of granules with improved technological characteristics and yields. Granules were characterized by granulometry, reological parameters, compression and hygroscopic behavior. Independent of the granulation technique, technologically developed granules presented particle diameter, bulk and tapped densities and compressibility indexes suitable for a solid dosage form. The compression behavior showed plastic and fragmentary deform
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Ayalasomayajula, Lakshmi Usha, E. Radha Rani, A. V. S. Ksheera Bhavani, and A. Vyasa Murty. "Effect of Granulation Methods on Drug Release Studies in Sustained Release Matrix Tablets of a Poorly Soluble Drug prepared using Synthetic Polymers." Journal of Drug Delivery and Therapeutics 10, no. 3 (2020): 76–82. http://dx.doi.org/10.22270/jddt.v10i3.4073.

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Vomiting or emesis is the abnormal emptying of stomach and upper part of intestine through esophagus and mouth. It occurs due to stimulation of the emetic (vomiting) centre situated in the medulla oblongata. Domperidone, a D2 receptor antagonist has antiemetic and prokinetic action is used as a model drug in the present work to prepare Sustained release matrix tablets using various synthetic polymers like Eudragit and HPMC K15 M. The tablets are designed to have a pH dependent release profile in order to prevent initial drug release in the stomach to reduce the possible gastro-irritant and ulc
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Patra Ch, Niranjan, Satya Prakash Singn, Hemant Kumar P, and Vimala Devi M. "A Systematic Study on Flowability and Compressibility of Asparagus racemosus root Powder for Tablet Preparation." International Journal of Pharmaceutical Sciences and Nanotechnology 1, no. 2 (2008): 129–35. http://dx.doi.org/10.37285/ijpsn.2008.1.2.3.

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The dried root of Asparagus racemosus is widely used as mild antihypertensive and tranquilizer. The objective of the present research was to study the original flowability, compressibility and compactibility of Asparagus racemosus root powder and develop its tablet formulations by wet granulation and direct compression technology. The consolidation behavior of drug and tablet formulations were studied by using Heckel and Leuenberger equation. Asparagus racemosus root powder showed very poor flowability and compactibility. Kawakita analysis revealed improved flowability for formulations prepare
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Saeed, Humaira, Muhammad Ramzan, and Abid Hussain. "Effect of Polymer Type, Concentration and Formulation Technique on Mucoadhesive Strength and Swelling Index of Clarithromycin Tablets." Pharmaceutical Communications 2, no. 1 (2023): 19–29. http://dx.doi.org/10.55627/pharma.002.01.0281.

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This study aims to evaluate the effect of polymer type, concentration, and formulation technique on mucoadhesion and the Swelling Index of matrix tablets. Tablets were formulated by wet-granulation, solid dispersions, and direct compression techniques using different polymers in different concentrations (D:P 5:1, 5:2, and 5:3). Swelling Index and Mucoadhesive strength were analyzed for all the formulations (F1-15). The physicochemical parameters of the tablets were found to be within the acceptable limit. The swelling index for matrix tablets (F1-15) prepared by wet-granulations technique was
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SEVILLE. "Continuous Pharmaceutical Manufacture Using a Novel Wet Granulation Technique." Scientia Pharmaceutica 78, no. 3 (2010): 543. http://dx.doi.org/10.3797/scipharm.cespt.8.l03.

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8

Ni’matul Fauziah, Miftahul Maulidiyah, Silvia Nur Diana Putri, et al. "Review Artikel: Formulasi Tablet Menggunakan Metode Granulasi Basah." OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan 2, no. 4 (2024): 124–33. http://dx.doi.org/10.61132/obat.v2i4.535.

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Tablets are one of the most commonly used solid dosage forms of medicine in the pharmaceutical industry. The granulation process commonly used in making tablets is the wet granulation process. The operation method includes mixing the active ingredients and excipients, adding a binder liquid, forming granules, drying and sieving. The methods used in this research are literature research, journal reviews, and analysis of relevant papers carried out during the 2015-2023 period. The aim of this literature study is to determine the process, advantages, limitations and application of wet granulation
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9

Ying, Looi Shu, Mahibub Muhamadsaa Kanak, Noor Shahida Binti Ajmi, Vijay Kumar Methi, Rabia Basharat, and Lean Yen Loong. "Effect of Wet Granulation Technique on Preparation and Characterization of Piroxicam Inclusion Complexation." Caribbean Journal of Science and Technology 08, no. 01 (2020): 119–26. http://dx.doi.org/10.55434/cbi.2020.8108.

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The preparation of any pharmaceutical drug delivery system requires solubility as one of the top most requirements for active pharmaceutical ingredients. Inclusion Complexation has become popular in formulation development of water poor soluble active ingredients. In current study we have selected water poor soluble drug Piroxicam (PX) as the model active pharmaceutical ingredient. To release piroxicam drug from solid dosage forms such as tablets and capsules it requires improvement in its solubility prior to preparation of final dosage form. For large scale production and commercialization pr
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10

Kotamarthy, Lalith, Subhodh Karkala, Ashley Dan, Andrés D. Román-Ospino, and Rohit Ramachandran. "Investigating the Effects of Mixing Dynamics on Twin-Screw Granule Quality Attributes via the Development of a Physics-Based Process Map." Pharmaceutics 16, no. 4 (2024): 456. http://dx.doi.org/10.3390/pharmaceutics16040456.

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Twin-screw granulation (TSG) is an emerging continuous wet granulation technique that has not been widely applied in the industry due to a poor mechanistic understanding of the process. This study focuses on improving this mechanistic understanding by analyzing the effects of the mixing dynamics on the granule quality attributes (PSD, content uniformity, and microstructure). Mixing is an important dynamic process that simultaneously occurs along with the granulation rate mechanisms during the wet granulation process. An improved mechanistic understanding was achieved by identifying and quantif
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Jaida Rahma, Alya Puspita Dewi, Septia Miranti, Hendri Anugrah Wibowo, and Nabila Syifa Firdaus. "Formulasi Sediaan Tablet Dan Evaluasi Dari Jenis Zat Aktif Dengan Metode Granulasi Basah." Jurnal Sains Farmasi Dan Kesehatan 2, no. 2 (2024): 114–17. https://doi.org/10.62379/jfkes.v2i2.1791.

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This study aims to understand how the wet granulation technique can affect the physical quality and the effectiveness of active ingredient release in tablets. In this review, various types of active ingredients will be analyzed to evaluate how their chemical and physical properties, such as solubility, compressibility, and stability, influence the resulting tablet formulation. Wet granulation was chosen due to its ability to improve the flow, compressibility, and stability of the mixture of active ingredients and excipients, resulting in tablets with better quality. To achieve this objective,
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Kaushal, Sahil. "Formulation and Optimization of Omeprezole Floating Tablet by Wet Granulation Technique." Journal of Drug Delivery and Therapeutics 9, no. 3-S (2019): 679–87. http://dx.doi.org/10.22270/jddt.v9i3-s.2956.

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Omaprezole is a proton pump inhibitor, antacid drug. It is categorized as class II in BCS system of classification of drugs. Omaprazole inhibits the H(+)-K(-) ATPase in the proton pump of gastric parietal cells and highly effective inhibitor of gastric acid secretion. Floating tablet is nowadays considered as one of the best method to enhance the retention time of tablet in stomach. To get a better dissolution rate, the retention time of Omaprazole is enhanced by the floating technique. The aim of the work is to formulate the floating tablet of Omaprazole and evaluation of tablets invitro perf
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13

Dolas, Ramdas T., Shalindra Sharma, and Madhuraj Sharma. "FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF LAFUTIDINE." Journal of Drug Delivery and Therapeutics 8, no. 5 (2018): 393–99. http://dx.doi.org/10.22270/jddt.v8i5.1898.

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The purpose of this research was to develop a novel gastroretentive drug delivery system based on wet granulation technique for sustained delivery of active agent. Quick GI transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to decreased efficacy of the administered dose and thus less patient compliance. Gastroretentive floating tablets, which was designed to provide the desired sustained and complete release of drug for prolonged period of time. Gastroretentive floating tablets of lafutidine were prepared by wet granulation technique
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14

Khan, Amjad. "Prediction of quality attributes (mechanical strength, disintegration behavior and drug release) of tablets on the basis of characteristics of granules prepared by high shear wet granulation." PLOS ONE 16, no. 12 (2021): e0261051. http://dx.doi.org/10.1371/journal.pone.0261051.

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High shear wet granulation is commonly applied technique for commercial manufacturing of tablets. Granulation process for tablets manufacturing is generally optimized by hit and trial which involves preparation of granules under different processing parameters, compression of granules and evaluation of the resultant tablets; and adjustment is made in granulation process on the basis of characteristics of tablets. Objective of the study was to optimize the process of high shear wet granulation and prediction of characteristics of tablets on the basis of properties of granules. Atenolol granules
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15

Choudhary, Nisha, Dipika Chavda, Vaishali Thakkar, and Tejal Gandhi. "Identification of Critical Factors Influencing the In-Vitro Dissolution o f Bicalutamide Tablets Prepared Using Madg Technique." Journal of Pharmaceutical Research 21, no. 1 (2022): 27–37. http://dx.doi.org/10.18579/jopcr/v21i1.ms21.81.

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This study was aimed to utilize the Moisture Activated Dry Granulation (MADG) technique to formulate Bicalutamide tablet and identify critical factors influencing its dissolution. The Bicalutamide inclusion complex was formed using the kneading method. Aeroperl 300 was selected as an adsorbent, polyvinylpyrrolidone (PVP) K30 as a binder, Microcrystalline Cellulose (MCC) and Lactose Monohydrate (LMH) in1:1 ratio as fillers. Croscarmellose sodium (CCS) and neusilin were used as disintegrating agents, as they did not affect the disintegration time when hardness and compression force increased. Bo
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16

Zimmer, Łukasz, Katarzyna Świąder, Piotr Belniak, et al. "Formulation and evaluation of sulfadimidine and trimethoprim tablets using wet granulation technique." Current Issues of Pharmacy and Medical Sciences 25, no. 2 (2012): 202–6. http://dx.doi.org/10.12923/j.2084-980x/25.2/a.21.

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17

Sanskar, Biradar*1 Tushar Gaikwad2. "Formulation and Evaluation of Multi Nutrition Herbal Tablet." International Journal of Scientific Research and Technology 2, no. 4 (2025): 244–49. https://doi.org/10.5281/zenodo.15199306.

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This study employs the wet granulation method to develop and evaluate a multi-nutrition, herbal tablet consisting of Tulsi, Cinnamon, Clove and Ginger. The objective is to assess the tablet's quality through various factors, including thickness, hardness, weight variation, and friability. These potent herbs are incorporated due to their nutritional and therapeutic properties. The ingredients are effectively transformed into a tablet form for easy consumption using the wet granulation technique. Analyzing the tablet's physical properties provides valuable insights into its effectiveness and use
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18

Zhao, Jie, Geng Tian, and Haibin Qu. "Pharmaceutical Application of Process Understanding and Optimization Techniques: A Review on the Continuous Twin-Screw Wet Granulation." Biomedicines 11, no. 7 (2023): 1923. http://dx.doi.org/10.3390/biomedicines11071923.

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Twin-screw wet granulation (TSWG) is a method of continuous pharmaceutical manufacturing and a potential alternative method to batch granulation processes. It has attracted more and more interest nowadays due to its high efficiency, robustness, and applications. To improve both the product quality and process efficiency, the process understanding is critical. This article reviews the recent work in process understanding and optimization for TSWG. Various aspects of the progress in TSWG like process model construction, process monitoring method development, and the strategy of process control f
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19

Mhaske, Padmaja K. "Formulation and Evaluation of Sustained Release Matrix Tablet Metformin Hydrochloride." International Journal for Research in Applied Science and Engineering Technology 11, no. 6 (2023): 3535–45. http://dx.doi.org/10.22214/ijraset.2023.54350.

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Abstract: The present study outlines a systematic approach for designing and development of Metformin Hydrochloride sustained release matrix tablets. Different formulations were formulated by wet granulation technique using Xanthan gum and HPMC K100M as polymers along with other excipients The formulations were evaluated for their physicochemical properties.
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20

Heim, Thomas, and Frank Kern. "Influence of the Feedstock Preparation on the Properties of Highly Filled Alumina Green-Body and Sintered Parts Produced by Fused Deposition of Ceramic." Ceramics 6, no. 1 (2023): 241–54. http://dx.doi.org/10.3390/ceramics6010014.

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This paper investigates new approaches for the blending and plastification of ceramic powder with a binder to form fused deposition of ceramic (FDC) feedstock. The fabrication of highly filled ceramic filaments was accomplished using the granulation by agitation technique, followed by twin-screw extruder homogenization and single-screw extruder filament extrusion. The feedstocks are based on alumina (Al2O3) powders, which were prepared with an industrial binder through three different routes: wet granulation, melt granulation and melt granulation with a suspension. After printing cubic samples
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Subramonian, Sivarao, Md Radzai bin Said, Omar Rostam, et al. "Top Spray Fluidized Bed Granulated Paddy Urea Fertilizer." Applied Mechanics and Materials 606 (August 2014): 137–40. http://dx.doi.org/10.4028/www.scientific.net/amm.606.137.

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Top spray granulation process is a common technique used widely in pharmaceutical, food and special chemical modification for fertilizer manufacturing. Nevertheless, there is still a lack of studies regarding to the description of controlled parameters with dynamic correlation in targeting to produce urea granules. Thus, this research was carried out to introduce the crucial applied process parameters using top spray technique for paddy urea fertilizer production.The acquisition process parameter readings were verified by obtained yield of urea granules (UG) which featured as an optimum partic
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Lee, Kai T., Andy Ingram, and Neil A. Rowson. "Twin screw wet granulation: The study of a continuous twin screw granulator using Positron Emission Particle Tracking (PEPT) technique." European Journal of Pharmaceutics and Biopharmaceutics 81, no. 3 (2012): 666–73. http://dx.doi.org/10.1016/j.ejpb.2012.04.011.

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Kotamarthy, Lalith, Chaitanya Sampat, and Rohit Ramachandran. "Development of a Granule Growth Regime Map for Twin Screw Wet Granulation Process via Data Imputation Techniques." Pharmaceutics 14, no. 10 (2022): 2211. http://dx.doi.org/10.3390/pharmaceutics14102211.

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Twin screw granulation (TSG) is a continuous wet granulation technique that is used widely across different solid manufacturing industries. The TSG has been recognized to have numerous advantages due to its modular design and continuous manufacturing capabilities, including processing a wide range of formulations. However, it is still not widely employed at the commercial scale because of the lack of holistic understanding of the process. This study addresses that problem via. the mechanistic development of a regime map that considers the complex interactions between process, material, and des
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B., Divya* J. Sreekanth D. Satyavati. "FORMULATION AND EVALUATION PARAMETERS OF EXTENDED-RELEASE TABLETS OF ILAPRAZOLE BY USING NATURAL AND SYNTHETIC POLYMERS." Journal of Pharma Research 05, no. 12 (2016): 256–67. https://doi.org/10.5281/zenodo.6413946.

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ABSTRACT Ilaprazole is a Proton Pump Inhibitor (PPI), an anti-acidic drugused in the treatment of dyspepsia, peptic and duodenal ulcer disease, gastroesophageal reflux disease (GERD).Ilaprazole at oral doses of 10 mg has shown higher suppression of gastric acid secretion and more prolonged plasma half-life, and similar safety compared to 20 mg omeprazole. Elimination half-life for Ilaprazole ranged from 4.7 to 5.3 h, Administration of Ilaprazole in an extended-release dosage form would be more desirable by maintaining the plasma drug concentrations at a prolonged period of time. It will be mor
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B. H. Al-Khedairy, Eman. "In Vitro Release Study on Capsules and Tablets Containing Enteric - Coated Granules Prepared by Wet Granulation." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 15, no. 1 (2017): 49–52. http://dx.doi.org/10.31351/vol15iss1pp49-52.

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Wet granulation method was used instead of conventional pan coating or fluidized –bed coating technique to prepare enteric-coated diclofenac sodium granules, using ethanolic solution of EudragitTM L100 as coating, binding and granulating agent .Addition of PEG400 or di-n-butyl phthalate as a plasticizer was found to improve the enteric property of the coat.
 Part of the resulted granules was filled in hard gelatin capsules (size 0), while the other part was compressed into tablets with and without disintegrant.
 The release profile of these two dosage forms in 0.1N HCl (pH 1.2)for
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Afzal, Muhammad, Firoz Anwar, Md Shamim Ashraf, et al. "Formulation and evaluation of sustained release matrix tablet of rabeprazole using wet granulation technique." Journal of Pharmacy and Bioallied Sciences 6, no. 3 (2014): 180. http://dx.doi.org/10.4103/0975-7406.130961.

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Antil, Anita, Sukhbir Singh, Naleem Sharma, and Rahul Sharma. "Formulation Development and Evaluation of Taste Masked Anthelmintics Chewable Tablets by Using Fluid Bed Processor Technique." ECS Transactions 107, no. 1 (2022): 9003–13. http://dx.doi.org/10.1149/10701.9003ecst.

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Human helminthic infections are prevalent and have serious world health consequences. Praziquantel is frequently recommended anthelmintic therapy provided in tablet form for the oral treatment of schistosome infections. The goal of this study is to create and analyze a patient-friendly flavor masked anthelmintics chewable tablet of Praziquantel using Eudragit® EPO using a "granules coating technology" using a Fluid Bed Processor GPCG 1.1. (Top Spray). This strategy is better as compared to coating of Praziquantel granules with Eudragit EPO in Rapid Mixer Granulator. Due to its limited water so
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Fekete, Roman, Peter Peciar, Martin Juriga, et al. "Pressure and Liquid Distribution under the Blade of a Basket Extruder of Continuous Wet Granulation of Model Material." Journal of Manufacturing and Materials Processing 8, no. 3 (2024): 127. http://dx.doi.org/10.3390/jmmp8030127.

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This study explores the influence of blade design on the low-pressure extrusion process, which is relevant to techniques like spheronization. We investigate how blade geometry affects the extruded paste and final product properties. A model paste was extruded through a basket extruder with varying blade lengths to create distinct wedge gaps (20°, 26° and 32° contact angles). The theoretical analysis explored paste behavior within the gap and extrudate. A model material enabled objective comparison across blade shapes. Our findings reveal a significant impact of blade design on the pressure pro
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Tambe, Bhavana Dnyandeo. "Formulation and Evaluation of Paracetamol Effervescent Tablet." Asian Journal of Pharmaceutical Research and Development 9, no. 4 (2021): 47–51. http://dx.doi.org/10.22270/ajprd.v9i4.982.

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Oral dosage forms are the most popular way of taking medication, despite having some disadvantages compared with other methods like risk of slow absorption of the medicament, which can be overcome by administering the drug in liquid form, therefore, possibly allowing the use of a lower dosage. However, instability of many drugs in liquid dosage form limits its use. Effervescent technique can be used as alternate to develop a dosage form which can accelerate drug disintegration and dissolution, is usually applied in quick release preparations. The tablet is added into a glass of water just befo
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Draksiene, Gailute, Brigita Venclovaite, Lauryna Pudziuvelyte, Liudas Ivanauskas, Mindaugas Marksa, and Jurga Bernatoniene. "Natural Polymer Chitosan as Super Disintegrant in Fast Orally Disintegrating Meloxicam Tablets: Formulation and Evaluation." Pharmaceutics 13, no. 6 (2021): 879. http://dx.doi.org/10.3390/pharmaceutics13060879.

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The aim of the present investigation was to formulate fast disintegrating tablets of meloxicam by wet granulation technique using medium molecular weight chitosan. The orally disintegrating tablets of meloxicam with chitosan showed good mechanical and disintegration properties and good dissolution rate when prepared in tablet press using 10.8 kN and 11.0 kN compression force. Chitosan is a suitable biopolymer to moderate the disintegration process in orally disintegrating tablets.
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Pawar, Sandip R., Anil S. Mahajan, Md Rageeb, Md Usman, Tanvir Y. Shaikh, and Bharat V. Jain. "Development and Evaluation of Oral Fast Disintegrating Tablets of Warfarin Prepared by Wet Granulation Technique." International Journal of Pharmaceutical Sciences Review and Research 65, no. 1 (2020): 156–60. http://dx.doi.org/10.47583/ijpsrr.2020.v65i01.023.

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Tran, Bao Ngoc, Hiep Tuan Tran, Giang Thi Le, et al. "Solidifying Fenofibrate Nanocrystal Suspension: A Scalable Approach via Granulation Method." Journal of Nanomaterials 2023 (December 26, 2023): 1–11. http://dx.doi.org/10.1155/2023/1672030.

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The pharmaceutical industry has highlighted particle-size reduction via preparing aqueous suspensions containing nano- or submicron drug particles. Owing to the risk of agglomeration and complications during the manufacturing of solid dosage forms, the problems associated with the solidification of nanosuspensions need to be addressed. Herein, the nanocrystallized suspension of fenofibrate (Feno) was prepared using the wet-milling technique, and then two solidification methods, mixing (liquid mixing) and granulation (dry powder blending and wet massing) methods, were investigated. The solidifi
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Waleed, Shahad Qutaiba. "Effect of HPMC Concentration and Liquid Addition Method on granules properties using High-Shear Wet Granulator." Reaktor 24, no. 3 (2025): 102–8. https://doi.org/10.14710/reaktor.24.3.102-108.

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Enhancing the physical properties of medicinal powders is largely dependent on the granulation process. This study investigates how the concentration of hydroxypropyl methylcellulose (HPMC) and the liquid addition technique (pouring versus syringe) interact to affect the distribution of granule sizes and its porosity in a high-shear mixer setup. Both a 5% HPMC solution and distilled water (0% HPMC) were used to granulate calcium carbonate powder. The results showed that while excessive liquid addition using the pouring method led to uneven growth and agglomeration, an increase in binder viscos
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Miyamoto, Yousuke, Shigeo Ogawa, Masaharu Miyajima, et al. "An application of the computer optimization technique to wet granulation process involving explosive growth of particles." International Journal of Pharmaceutics 149, no. 1 (1997): 25–36. http://dx.doi.org/10.1016/s0378-5173(96)04853-3.

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Muddu, Shashank Venkat, Lalith Kotamarthy, and Rohit Ramachandran. "A Semi-Mechanistic Prediction of Residence Time Metrics in Twin Screw Granulation." Pharmaceutics 13, no. 3 (2021): 393. http://dx.doi.org/10.3390/pharmaceutics13030393.

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This work is concerned with the semi-mechanistic prediction of residence time metrics using historical data from mono-component twin screw wet granulation processes. From the data, several key parameters such as powder throughput rate, shafts rotation speed, liquid binder feed ratio, number of kneading elements in the shafts and the stagger angle between the kneading elements were identified and physical factors were developed to translate those varying parameters into expressions affecting the key intermediate phenomena in the equipment, holdup, flow and mixing. The developed relations were t
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Jangid, Vikash, Arindam Chatterjee, Saurabh Pandey, Vikash Agarwal, and Deeksha Sharma. "Formulation and Evaluation of Bi-Layer Tablet of Nebivolol and Nateglinide." Journal of Biomedical and Pharmaceutical Research 12, no. 3 (2023): 34–42. http://dx.doi.org/10.32553/jbpr.v12i3.993.

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In the present work, the Bilayered matrix type tablet were prepared by direct and wet granulation technique, in which immediate release layer ( by direct compression) contains Nebivolol and extended release layer (by wet granulation) contains Nateglinide. All the developed bilayer tablets were evaluated for weight variation, friability, thickness and hardness. The percent deviation from the average weight, friability, thickness and hardness was found to be within the prescribed official limits. Release profile of Nebivolol from formulations indicate that lower MCC (Formulations CF1 and CF3) an
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Dr. Payal N. Vaja, Dr Payal N. Vaja, and Mr Uttamkumar V. Rakholiya Mr. Uttamkumar V. Rakholiya. "Formulation and Optimization of Fast Dissolving Tablets of Omeprazole Using Design of Experiments (DoE) Approach." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 1550–61. https://doi.org/10.35629/4494-100315501561.

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Objective The main objective of this study was to formulate and evaluate fast dissolving tablets of Omeprazole using direct compression and wet granulation methods and to compare their performance based on various physicochemical parameters and compare the drug release profiles of different formulations to identify the most effective formulation for rapid disintegration and maximum drug release. Method Formulations were developed using direct compression method and formulation variables such as superdisintegrant and binder concentrations were optimized using Box-Behnken Design (BBD). The table
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D. V. R. N., Bhikshapathi, Arun Kumar Jarathi, Suresh Gande, Viswaja Medipally, and Ramesh Bomma. "Gastroretentive Floating Capsules of Risedronate Sodium: Development, Optimization, in vitro and in vivo Evaluation in Healthy Human Volunteers." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 2 (2015): 2835–42. http://dx.doi.org/10.37285/ijpsn.2015.8.2.6.

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Background and the purpose of the study: Risedronate sodium inhibits osteoclast bone resorption and modulates bone metabolism. Risedronate has a high affinity for hydroxyapatite crystals in bone and is a potent antiresorptive agent. In the present investigation efforts were made to improve the bioavailability of risedronate sodium by increasing the residence time of the drug through sustained-release matrix capsule formulation via gastroretentive mechanism. Capsules were prepared by wet granulation technique. The influence of gel forming agents, amount of risedronate and total weight of capsul
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Kavita, Dindawar, B. M. Supriya, and Kolageri Shivanand. "Effect of Lubricants on Properties of Conventional Tablets of Antihypertensive Drugs from Different Biopharmaceutical Classification System." Asian Journal of Pharmaceutical Research and Development 11, no. 5 (2023): 53–63. http://dx.doi.org/10.22270/ajprd.v11i5.1303.

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 Background: Hypertension is a long-term medical condition in which blood pressure in the arteries is elevated. Hypertension causes coronary artery disease, stroke, heartfailure; kidney diseases etc.to over come hypertension, antihypertensive drugs are used.
 Objectives: The aim of present work was to find out effectsof lubricants on properties of conventionaltablets containing antihypertensive drugs from different BCS class. Antihypertensive drugs suchas Metoprolol succinate, and Atenolol were selected which represented BCS class I, and II respectively.
 Methods: Lubric
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Abbas, Muhammad, Musharraf Abbas, Fatima Tariq, Rabiya Yasin, and Muhammad Nabeel. "Formulation and evaluation of chewable tablets of Desloratadine prepared by aqueous and non-aqueous techniques." Journal of Drug Delivery and Therapeutics 10, no. 1 (2020): 5–10. http://dx.doi.org/10.22270/jddt.v10i1.3796.

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In the modern era, chewable tablets are preferred over conventional dosage forms by pediatric, geriatric and bedridden patients due to difficulty in swallowing, lesser amount of water for swallowing medications as well as unable to tolerate the bitter taste of certain drugs. Chewable tablets of Desloratadine (DS) were formulated by aqueous and non-aqueous granulation method using water paste and Isopropyl alcohol (IPA) as a wetting agents respectively. Desloratadine is used to treat the symptoms of allergy such as sneezing, watery eyes. In the recent research, we have formulated eight trials b
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Adhikari, Diwas, Sharada Pokhrel, Meenakshi Kandwal, Arti Kori, and Shivanand Patil. "Study on Synergistic Effect of Dioctyl Sodium Sulfosuccinate, Sodium Starch Glycolate and Crospovidone on Drug Release Profile of Orodispersible Tablets of Rizatriptan Benzoate." Journal of Drug Discovery and Health Sciences 1, no. 04 (2024): 244–48. https://doi.org/10.21590/jddhs.01.04.08.

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Orodispersible Tablets are expected to have disintegration rapidly within the mouth cavity. To overcome the problems of solid dosage forms and to facilitate the patients with easy swallowing tablets pharmaceutical companies have formulated Oral Disintegrating Tablets, which disintegrate in saliva, within few seconds. Rizatriptan Benzoate can be formulated as Orodispersible tablet successfully by using the wet granulation process. Crospovidone, SSG and DOSS were used in the varying concentrations during the formulation. Other excipients like Microcrystalline Cellulose, Sodium Stearyl Fumarate,
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D, Nagasamy Venkatesh, Sankar S, S. N. Meyyanathan, K. Elango, B. Suresh, and Santhi K. "Design and Development of Prochlorperazine Maleate Sustained Release Tablets: Influence of Hydrophilic Polymers on the Release rate and In vitro Evaluation." International Journal of Pharmaceutical Sciences and Nanotechnology 3, no. 2 (2010): 965–77. http://dx.doi.org/10.37285/ijpsn.2010.3.2.10.

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The objective of the present investigation was to develop and evaluate sustained release matrix tablets of prochlorperazine maleate employing different types and levels of hydrophilic matrix agents namely hydroxyl propyl methyl cellulose (HPMC), carbopol and combination of these polymers by wet granulation technique. Prior to compression process, the prepared granules were evaluated for its flow and compression characteristics. The in vitro dissolution of the newly formulated sustained release tablets were compared with standard formulation. The excipients used in this study did not alter the
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Madgulkar, Ashwini R., Mangesh R. Bhalekar, Aishwarya Deepak Vaidya, Pauroosh Kaushal, and R. P. Mudalwadkar. "Development of Hot Melt Coating Technique for Taste Masking of Chloroquine Phosphate Tablets." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 562–68. http://dx.doi.org/10.22270/jddt.v9i4-s.3213.

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In the present study to mask the unpleasant taste of chloroquine phosphate, hot melt coating technique was used as a taste masking tool. Hot melt coating is a solvent free technology grants rapid, additionally economical coating process with reduced risk of dissolving drug during process and provide uniform application rate of coating agent. Precirol ATO 5 was used as hot melt coating material for taste masking. Tablets were prepared by wet granulation method and coated using hot melt coating technique. Coated tablets exhibited good uniformity of drug content. Amount of drug release from all b
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NK, Shinde, and Mane DV. "Development and Evaluation of Antifungal Drug Product by Solid Dispersion Technique using Drug Coating and Seal Coating Approach (Itraconazole Capsules 100 mg)." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 04 (2024): 1116–23. https://doi.org/10.25258/ijddt.14.4.28.

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A very important stage in developing and preserving the quality of any pharmaceutical drug product is validation. Drug product validation creates the written proof that offers a high level of certainty that a manufacturing process will reliably provide a product with predefined standards and quality features. Studying the process performance certification of the drug product Itraconazole Capsules 100 mg Immediate Release Capsule dosage form was the primary goal of my research. The research conducted here guarantees that the production process is appropriate for the intended use and that the fi
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Ansari, K. Kareemuddin, and Neeraj Sharma. "Formulation and evaluation of orodispersible tablets of lornoxicam." Journal of Drug Delivery and Therapeutics 8, no. 6 (2018): 225–28. http://dx.doi.org/10.22270/jddt.v8i6.2058.

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Orodispersible tablets (ODTs), also known as fast melt, quick melts, fast disintegrating have the unique property of disintegrating in the mouth in seconds without chewing and the need of water. The purpose of this investigation was to develop mouth dissolving tablets of Lornoxicam using KYRON T-314 (Polacrillin Potassium) as a novel superdisintegrant. Mouth dissolving tablets of lornoxicam were prepared by wet granulation technique using KYRON T-314 as superdisintegrant and menthol as subliming agent. The present study demonstrated potentials for rapid absorption, improved bioavailability, ef
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Shahidulla, SM, and Tayyaba Jeelani. "Formulation and In-Vitro Evaluation of Taste Masked Fast Disintegrating Tablets of Labetalol Hydrochloride by Wet Granulation Technique." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 442–49. http://dx.doi.org/10.22270/jddt.v9i4-a.3506.

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Labetalol Hydrochloride is a β-blocker generally indicated for the treatment of hypertension, and it is extensively metabolized due to the hepatic metabolism. In the present work, an attempt was made to mask the taste by Solid Dispersion technique, with a formulation into Fast Disintegrating dosage form, using superdisintegrants such as Cross carmellose sodium (CCS), crospovidone (CP) and sodium starch glycolate (SSG). The complexes of Labetalol hydrochloride with HP-β-CD (1:3 ratio) were prepared by Co-precipitation method. Using the drug HP-β-CD complex, Fast Disintegrating tablets were prep
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Bookya, Padmaja, Ramakrishna Raparla, Ramakrishna Raparla, et al. "FORMULATION AND EVALUATION OF METFORMIN HYDROCHLORIDE SUSTAINED-RELEASE ORAL MATRIX TABLETS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 3 (2018): 342. http://dx.doi.org/10.22159/ajpcr.2018.v11i3.21211.

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Objective: The aim of this investigation was to develop and optimize metformin hydrochloride matrix tablets for sustained release application. The sustained release matrix tablet of metformin hydrochloride was prepared by wet granulation technique using chitosan, xanthan gum, and hydroxypropyl methylcellulose at varying concentrations.Material and Methods: Extended release of metformin hydrochloride matrix tablets was prepared by wet granulation method. The influence of varying the polymer ratios was evaluated. The excipients used in this study did not alter physicochemical properties of the d
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Nikita, Bhosale, Velhal Atish, Redasani Vivek Kumar, Raut Poonam, and Varda Joshi. "An Overview Onsustained Release Formulations Using Solid Dispersion as Solubility Enhancement Technique." Asian Journal of Pharmaceutical Research and Development 11, no. 3 (2023): 84–91. http://dx.doi.org/10.22270/ajprd.v11i3.1257.

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Biopharmaceutical classification system is important for determining the bioavailability of the drug. Drugs that dissolve slowly in water can be effectively solid-dispersed to increase their bioavailability. The bioavailability issue can be due to insufficient solubility of permeability. The poorly water-soluble medication dissolves more quickly when combined with the water-soluble carriers used to make solid dispersion. The review paper concentrates on the preparation techniques, benefits, drawbacks, and characterization of solid dispersion. Pharmaceuticals with sustained release have recentl
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Maity, Siddhartha, and Biswanath Sa. "Development and Evaluation of Ca+ 2 Ion Cross-Linked Carboxymethyl Xanthan Gum Tablet Prepared by Wet Granulation Technique." AAPS PharmSciTech 15, no. 4 (2014): 920–27. http://dx.doi.org/10.1208/s12249-014-0123-x.

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Herman Yosef Limpat Wihastyoko, Ellenora Resti Mustikaningrat, Dorothea Respa Kusumaningrat, Gisella Sekar Wruhastanti, and Yohana Joni. "USING OF NEGATIVE WOUND PRESSURE THERAPY (NPWT): A CASE SERIES OF WOUND DISRUPTION AS A COMPLICATION OF A CAESAREAN SECTION." Jurnal Rekonstruksi dan Estetik 9, no. 1 (2024): 11–18. http://dx.doi.org/10.20473/jre.v9i1.53349.

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Highlights: Surgical site infection during caesarean section can cause complications, thereby increasing maternal mortality and morbidity, especially in groups at risk. VAC therapy can stimulate granulation tissue formation so that primary wound junctions occur. VAC shows its ability to close wounds entirely within 3-4 weeks. Abstract: Introduction: Wound disruption following caesarean sections is a common issue that can increase maternal mortality and morbidity. Several factors have been identified, including maternal, procedural, and antibiotic factors. The re-suturing method, primer, and se
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