Dissertations / Theses: 'Where to go'

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Cochran, Karina. "Where All Good Rabbits Go." Research Showcase @ CMU, 2016. http://repository.cmu.edu/theses/115.

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O'Donnell, James M. "Where do we go from here?" Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/art_design_theses/113.

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Where do we go from here? is a video installation by Atlanta-based artist James O’Donnell that attempts to provoke others into similar contemplation of that existential question through an immersive video and audio installation exploring the self through references to the internal and external; past and future; and connection and disconnection.

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Myers, C., Patricia M. Vanhook, B. Pilon, and B. McCann. "Where Do We Go From Here?" Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/7427.

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吳利豪 and Lee-ho Ng. "The computer industry - where does it go?" Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1993. http://hub.hku.hk/bib/B31265753.

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Ng, Lee-ho. "The computer industry - where does it go? /." [Hong Kong : University of Hong Kong], 1993. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13498472.

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Shade, Robert J. "Choosing where to go : mobile robot exploration." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:4a7d5578-f354-48e9-80b4-f3c83234be5f.

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For a mobile robot to engage in exploration of a-priori unknown environments it must be able to identify locations which will yield new information when visited. This thesis presents two novel algorithms which attempt to answer the question of choosing where a robot should go next in a partially explored workspace. To begin we describe the process of acquiring highly accurate dense 3D data from a stereo camera. This approach combines techniques from a number of existing implementations and is demonstrated to be more accurate than a range of commercial offerings. Combined with state of the art visual odometry based pose estimation we can use these point clouds to drive exploration. The first exploration algorithm we present is an attempt to represent the three dimensional world as a continuous two dimensional surface. The surface is maintained as a planar graph structure in which vertices correspond to points in space as seen by the stereo camera. Edges connect vertices which have been seen as adjacent pixels in a stereo image pair, and have a weight equal to the Euclidean distance between the end points. Discontinuities in the input stereo data manifest as areas of the graph with high average edge weight, and by moving the camera to view such areas and merging the new scan with the existing graph, we push back the boundary of the explored workspace. Motivated by scaling and precision problems with the graph-based method, we present a second exploration algorithm based on continuum methods. We show that by solving Laplace’s equation over the freespace of the partially explored environment, we can guide exploration by following streamlines in the resulting vector field. Choosing appropriate boundary conditions ensures that these streamlines run parallel to obstacles and are guaranteed to lead to a frontier – a boundary between explored and unexplored space. Results are shown which demonstrate this method fully exploring three dimensional environments and outperforming oft-used information gain based approaches. We show how analysis of the potential field solution can be used to identify volumes of the workspace which have been fully explored, thus reducing future computation.

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Crewe-Kluge, Silas. "Where Do You Go When You Go Home? Narrative Studies of Gender Euphoria." Oberlin College Honors Theses / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=oberlin1620217556606262.

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Weinberg, Jessica P., and Susan D. Penfield. "Mohave Language Planning: Where Has It Been and Where Should It Go from Here?" University of Arizona Linguistics Circle, 2000. http://hdl.handle.net/10150/226605.

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The Colorado River Indian Tribes (CRIT), in Parker, Arizona, include four Native Arizonan tribes, Mohave, Chemehuevi, Navajo, and Hopi. These tribes function politically as a unit, although they are distinct in terms of language, culture, and history. While all Native American languages are endangered today, for two of the Colorado River Indian Tribes, the Mohave and Chemehuevi, the language situation is critical. In this paper, we will be concerned only with language planning as it relates to Mohave. As a background for the current language planning situation for Mohave, we briefly discuss the history and current circumstances of the CRIT reservation. We provide a short history of linguistic work on Mohave, we discuss current language planning efforts focused on Mohave, and finally, we make recommendations for continued language preservation and revitalization of Mohave.' We conclude that language planning on the CRIT reservation must involve efforts focused on each of the four tribal languages as well as the blending of language planning efforts for all four CRIT languages to reflect the integrated social reality of the CRIT.

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RIBEIRO, LUCIA GOMES. "WHERE AM I? WHERE DO I GO?: ERGONOMICS IN BUILT ENVIRONMENT: WAYFINDING AND AIRPOTS." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2009. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=32541@1.

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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO
A partir da compreensão da abordagem de wayfinding e do entendimento dos aspectos de um terminal de passageiros de transporte aéreo foi possível mapear os problemas existentes em três terminais de passageiros aéreos. A pesquisa de campo foi baseada em dois métodos principais: a observação e a inquirição. Dentro da abordagem de wayfinding apresentada, ficou claro que a dimensão comunicativa do ambiente constitui a base da relação entre ambiente e usuário, e da navegação espacial. A descrição do terminal de transporte de aeroportos mostrou a importância que é dada para as questões de wayfinding dentro do cenário do transporte aéreo mundial. Através dos capítulos teóricos, ficou evidente também que para alcançar a melhor eficiência nos projetos de wayfinding os sistemas informacionais devem atuar em conjunto. Além disso, o próprio ambiente construído deve interagir com o comportamento do usuário e a parte organizacional do ambiente. Isso deve ser preocupação constante dos projetistas do ambiente construído. Os resultados obtidos na pesquisa, e as análises realizadas, mostraram que os três terminais estudados possuem problemas de orientabilidade em seus sistemas informacionais. Uns enfrentam inadequações mais expressivas em suas informações arquitetônicas, outros em seus objetos, e outros nas informações adicionais, principalmente as placas de sinalização.
According to wayfinding approach, it was found the existents problems on three airports terminals. Field research was based on two main techniques: observation and interviews. It became clear that communicational dimension f the built environment is the base for the relationship between environment and the user, and the spatial navigation. The airport terminals description shows the relevance for wayfinding questions concerning the global air transportation. After the literature review became evident that to aim the best efficiency in wayfinding design the informational systems must be together. Besides that the built environment must interact with the user and organizational aspects. This must be an important criterion for built environmental designers. The results and their analysis point out that the three terminals present orientability problems in their informational systems. In some of them inadequacies are more expressive in the architectural design, other in the objects, and other in additional information, mainly in signing systems.

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Veskoukis, Alexandra. "Where have we been, where are we now and where could we go? : Re imagining the accessibility of digital maps." Thesis, Malmö universitet, Institutionen för konst, kultur och kommunikation (K3), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-43647.

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By investigating digital maps with an inclusive- and research through design approach, this research project aims on answering the research question: how can a digital map convey accessibility information of a route before the journey without the need of special adaptation?The research question involves two issues, how digital maps can convey information about a route and what accessibility information of a route is.With Rätt från början and the Swedish Agency for Accessible Media as stakeholders, a recruitment of participants with different capabilities, preference, characteristics, and needs was completed to explore how the participants use digital maps and perceive accessibility of the physical world by using the methods of interviews and design probes.The design process resulted in prototypes of a digital map that affords exploration without displaying normative standards of accessibility by using a design strategy of presenting the world as it is through audio-haptic and visual communication.

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Medler, David A. "The crossroads of connectionism, where do we go from here?" Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape15/PQDD_0016/NQ29077.pdf.

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Cummins, Declan. "Small molecules : where do they go to on tea leaves?" Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12961/.

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The aims of this project were to investigate the surface chemistry and morphology of processed tea leaves the techniques of atomic force microscopy (AFM), scanning electron microscopy (SEM) and time of flight secondary ion mass spectrometry (ToF-SIMS). Data from the spectra obtained by ToF-SIMS was also analysed using principal component analysis (PCA). Further experimentation was performed on tea leaves by the addition of diluted samples of aromas, methyl salicylate, trans-2-hexenal and linalool and examining these leaves using depth profiling to discover how far into the leaf the aroma had penetrated and if there was any connection between the chemistry and size of the aromas and how far they penetrated. A general characterisation of the tea leaves was performed in Chapter 3 where layers of waxes of a comparable size were observed on both green and black tea leaves with AFM, as were micro-crystals on black tea and areas showing two distinct types of interaction between the cantilever tip and the surface of a green tea leaf indicating different surface properties. SEM images revealed a visual difference between green and black tea leaves, where the black tea leaves had more debris on the surface and greater changes in topography due to the different processing methods. The presence of lipids and epicuticular waxes were observed on the surface of the tea leaves using the ToF-SIMS. In Chapter 4 the effects of infusion in hot water on the morphology and surface chemistry of the tea leaves are examined. SEM revealed structural damage to the leaves from 30 seconds of infusion and this increased with infusion time, resulting in the formation of holes in the cutin on the adaxial surface of the tea leaf. By examining positive and negative ToF-SIMS spectra and using PCA, a change in surface chemistry could be detected from 15 seconds of infusion. The intensity of C3H5O2+ peaks in the spectra increased as infusion time increased, indicating that the waxy cuticle of the leaf surface had been removed revealing the underlying epidermal cell layer. Peaks associated with octadecenoic and octadecanoic acids were shown to have a reproducible effect on the positioning of the different infusion times within the PCA plots. Though chemical changes can be detected at 15 seconds, the first 30 seconds of infusion were found to be responsible for the majority of the chemical changes on the surface. Taken together these data indicate that the melting of the cutin layer, primarily within the first 30 seconds of infusion may be related to the release of flavour, aroma and constituents such as polyphenols. The penetration into the leaf of aroma molecules was examined in Chapter 5. Diluted solutions of methyl salicylate, linalool and trans-2-hexenal were added to tea leaves and then examined using depth profiling with ToF-SIMS. For the first time a leaf was depth profiled using a C60. The presence of trans-2-hexenal was detected in the palisade mesophyll layer of the leaf as was methyl salicylate, but to a smaller intensity. Methyl salicylate showed partitioning in diffusion across the cuticle with a large intensity in the cuticle and also in the interface between the epidermis and palisade mesophyll layers. Linalool was present on the surface of the leaf and showed partitioning in the cuticle of the tea leaves. As trans-2-hexenal was the smallest and least lipophilic of the three aromas examined it is theorized that the smaller the size of the aroma molecule plays a key role in the penetration of the dehydrated leaves.

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Harris, Justin. "Where will it go? Concepts of motion in complex events." Diss., Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/239070.

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Psychology
Ph.D.
Common misconceptions provide a window into how people learn about and understand the world. This study explores the misconceptions of both children (5.5 to 6.5 year olds) and adults of how multiple components of motion combine in complex events. Children were shown to have basic, accurate conceptions of complex motion, but only if all components of motion were in the same dimension. For events that span two dimensions most children responded inconsistently, but some already showed a common adult misconception - one force dominating the motion. Across all ages, dominance was most strongly elicited when forces were applied sequentially, with the most recently applied force determining the motion. The results suggest a developmental trajectory for (mis)conceptions of motion that is strongly influenced by a tendency to incorrectly break complex events down into independent sub-events. Evidence also points to spatial thinking as a potentially important tool for fostering correct conceptions of motion.
Temple University--Theses

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Deaton, Dollie. "CYBERSPACE INVADES THE FIRST AMENDMENT: Where do we go from here?" UKnowledge, 2001. http://uknowledge.uky.edu/gradschool_theses/216.

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Long before our nation was created, European Countries acknowledged the importance of freespeech. Despite this, Great Britain later denied this right to the New England Colonies. Over thelast two centuries many battles have been fought to make freedom of speech an inalienable right tobe shared by all. A good portion of these battles have been fought in courtrooms. Judge andSupreme Court justices have dealt with issues ranging from what is a public figure to what isindecent speech. Many of these issues are not found in the original text of the Constitution. This hasforced the judges to devise tests to determine certain standards and to make discretionary choices.Today's public officials are dealing with issues that have never been dealt with before, such asInternet speech and cyberspace libel. The decisions rendered by the courts on these new issues willset a precedent for future generations. What kind of effect of this new territory, known ascyberspace, will have on the First Amendment is yet to be seen.

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Deaton, Dollie F. "Cyberspace invades the First Amendment where do we go from here? /." [Lexington, Ky. : University of Kentucky Libraries], 2001. http://lib.uky.edu/ETD/ukycomm2001t00004/thisone.pdf.

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Clements, Andrea D. "Cortisol Measurement in Developmental Research: Where Do We Go From Here?" Digital Commons @ East Tennessee State University, 2013. https://doi.org/10.1002/dev.21025.

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Salivary cortisol has been measured extensively in developmental research over the last three decades. The purpose of this article is to summarize the contributions to and limitations of salivary cortisol measurement in developmental research and propose future directions for research that includes salivary cortisol measurement. The properties of cortisol, the history of its burgeoning popularity, and the utility and limitations of (a) cortisol as a biological indicator, (b) saliva as a source of cortisol, and (c) various saliva collection methodologies are described. The current state of understanding about what is and is not reliably predictable from cortisol is summarized and the value of salivary cortisol measurement in developmental research is discussed, addressing whether methodology could be driving research design. Recommendations are made for streamlining study design and reporting within developmental research.

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Whittier, Jeremy, and Christina R. Kalel. "Where did you go? Encouraging female participation within Red Hat, Inc." The University of Arizona, 2016. http://hdl.handle.net/10150/608318.

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Edited by Dr. Brandy A. Brown and Romi C. Wittman
As U.S.-based companies continue to struggle to fill science, engineering and technology (SET) positions with domestic talent, a large portion of the available workforce (women) continues to be underrepresented. This project discusses the strategic advantages of encouraging female workforce participation in SET roles within global technology companies. Three publicly traded companies - Netflix, Facebook and Red Hat, Inc. - are compared utilizing self-reported diversity numbers to see the varying levels of women in those workplaces. The diversity policies and benefits programs of these three companies are discussed as well as available corporate statements regarding workforce diversity policies. Finally, utilizing information from programs proven to increase women’s participation and retention within SET roles, suggestions are provided, namely sponsorship of women in the workplace.

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Ricciardi, Ryan A. "Where Did All the Women Go: The Archaeology of the Soldier Empresses." Cincinnati, Ohio : University of Cincinnati, 2008. http://rave.ohiolink.edu/etdc/view.cgi?acc_num=ucin1211507157.

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Thesis (Ph.D.)--University of Cincinnati, 2007.
Advisor: C. Brian Rose. Title from electronic thesis title page (viewed Sep.8, 2008). Keywords: Roman women; Imperial art; Roman Empire. Includes abstract. Includes bibliographical references.

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Bist, Ambika. "The Politics and Economics of Outsourcing: Where did all the jobs go?" Scholarship @ Claremont, 2015. http://scholarship.claremont.edu/scripps_theses/530.

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United States legislations have allowed U.S. companies to integrate with the economies of other countries allowing U.S. companies to outsource manufacturing and services abroad and take advantage of lower input cost because of cheap and skilled labor - an opportunity cost choice. In the global economy employment in the United States seems to be influenced simultaneously by variables such as outsourcing, international trade, foreign direct investment (FDI) and immigration. The shift in our economic and labor structure due to outsourcing will impact many different groups of people, mainly the next generation entering the labor market. The goal of this thesis is to examine the effects of outsourcing, Foreign Direct Investment, and International Trade on the U.S. labor market. It reveals that as an effect of outsourcing jobs have shifted to the emerging markets for cost and capability sourcing, but in response to the uproar on U.S. jobs being lost as businesses move abroad there seems more of job complementarily than substitution between parent and foreign affiliates. Also, companies are integrating vertically and that outsourcing is integral to a company’s success in the global economy. Furthermore FDI in the U.S. is not growing as rapidly as it is in Asia and many other parts of the world, when FDI is shown to positively affect a country’s economy. The U.S. because of the imbalance in international trade runs a huge trade deficit, which again takes a toll on the U.S. economy and employment. As the U.S. parent companies account for large shares of the overall U.S. economy, and foreign affiliates are also significant contributors to the U.S. economy there should be legislations that support multinationals to remain competitive in the global market as they contribute to strengthen the U.S. economy.

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McCrory, Dustin W. "Where Do We Go From Here? Multiliteracy and the Future of Narrative." ScholarWorks@UNO, 2013. http://scholarworks.uno.edu/td/1698.

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Words on a page are insufficient vehicles for complex ideas. When images and words appear together on the page, as in comics, the process of meaning-making through narrative functions more efficiently. Building on this idea, we must establish a “graphic narratology” to understand the process whereby meaning is transmitted. Analysis of narratological conventions, as well as the conventions of mass-market comics, provides a framework for this new narratology.

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Radmard, Sina. "Where did it go? : regaining a lost target for robot visual servoing." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/56804.

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When a robotic visual servoing/tracking system loses sight of its target, the servo fails due to loss of input. To resolve this problem, a search method is required to generate efficient actions and bring the target back into the camera field of view (FoV) as soon as possible. For high dimensional platforms like a camera-mounted manipulator, an eye-in-hand system, such a search must address the difficult challenge of generating efficient actions in an online manner while avoiding visibility and kinematic constraints. This work considers two common scenarios of visual servoing/tracking failure, when the target leaves the camera FoV and when visual occlusions, occlusions for brevity, disrupt the process. To handle the first scenario, a novel algorithm called lost target search (LTS) is introduced to plan online efficient sensor actions. To handle the second scenario, an improved algorithm called lost target recovery algorithm (LTRA) allows a robot to look behind an occluder during active visual search and re-acquire its target in an online manner. Then the overall algorithm is implemented on a telepresence platform to evaluate the necessity and efficacy of autonomous occlusion handling for remote users. Occlusions can occur when users in remote locations are engaged in physical collaborative tasks. This can yield to frustration and inefficient collaboration between the collaborators. Therefore, two human-subjects experiments are conducted (N=20 and 36 respectively) to investigate the following interlinked research questions: a) what are the impacts of occlusion on telepresence collaborations, and b) can an autonomous handling of occlusions improve telepresence collaboration experience for remote users? Results from the first experiment demonstrate that occlusions introduce a significant social interference that necessitates collaborators to reorient or reposition themselves. Subsequently, results from the second experiment indicate that the use of an autonomous controller yields a remote user experience that is more comparable (in terms of their vocal non-verbal behaviors, task performance and perceived workload) to collaborations performed by two co-located parties. These contributions represent a step forward in making robots more autonomous and user friendly while interacting with human co-workers. This is a necessary next step for successful adoption of robots in human environments.
Applied Science, Faculty of
Mechanical Engineering, Department of
Graduate

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Glanfield, Ross Edward. "Boldly to go where no man.., the feminist science fiction of Joanna Russ." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ35060.pdf.

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Cartwright, Luke Stephen. "Where do all the spoons go? : perceptions of parents of adult heroin users." Thesis, University of Hull, 2013. http://hydra.hull.ac.uk/resources/hull:8415.

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This thesis aims to discover what sorts of tensions (if any) were created for parents when their problematic drug using adult offspring were mandated into drug treatment programmes in the community, and when their offspring engaged with treatment in the prison setting. In addition, this research aims to develop an understanding about whether or not these types of intervention were welcomed by parents as a positive development towards addressing the problematic drug use of their offspring. Alternatively, did the involvement of the criminal justice system in drug treatment lead to additional or different difficulties for the parents? The objectives of the research are to analyse and interpret how the research participants (the parents of problematic drug users) experience the involvement of the criminal justice system in treating the problematic drug use of their offspring. This research does not consider whether or not the involvement of families in the treatment process of problematic drug users is effective, but rather this research investigates the application of policies that seek to involve parents in the treatment journey of problematic drug users. Moreover, this study does not attempt to offer an explanation for problematic drug use, or offer suggestions about how to encourage the parents of problematic drug users to become involved in the treatment process, or what alternatives exist for those without parents.

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Placido, Nicholas J. "Where does the pastor go? pastoral burnout and the role of social support /." Online full text .pdf document, available to Fuller patrons only, 2002. http://www.tren.com.

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Mulvey, Connolly Erin (Erin Helen), and Emily Keane. "Where did all of the totes go? : a study in supply chain design." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/68895.

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Thesis (M. Eng. in Logistics)--Massachusetts Institute of Technology, Engineering Systems Division, 2011.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 82-83).
Corporations are increasingly looking at ways to incorporate environmental sustainability initiatives into their businesses to lower operating costs and improve the value of their brands for customers that expect higher social responsibility from corporations. These environmental initiatives, often called "win-win" for their dual effect on long-term shareholder value, are easy to identify but often hard to incorporate into existing operations. One such initiative in the retail industry involves delivering products to customers in reusable plastic cartons, rather than corrugated cardboard. One of the largest challenges when designing and implementing this type of supply chain system is developing a reverse logistics strategy that ensures carton return by the consumers, whom the corporation must convince to participate in closing the logistics loop. This thesis analyzes a pilot program conducted by a consumer products company, referred to as the Sponsor, where reusable plastic cartons were used to deliver orders to one of their corporate customers. Process mapping, qualitative interviews, and data analysis were utilized to understand factors contributing to the unacceptably high rate of carton attrition. Using the results of this analysis, two new design tracks are proposed for the delivery of the Sponsor's products at MIT. One design relies on the current operating systems and structures to minimize investment by the Sponsor, while the other design is aimed at maximizing effort to optimize the system. The proposed programs consider both operational practicalities in the logistical design and communication and incentive efforts that are needed to drive consumer behavior to maximize carton return and lower attrition rates. We believe the recommended implementation of the maximized effort design will result in lower carton attrition, which will provide the necessary proof of concept for the Sponsor to roll the program out to additional customers.
by Erin Mulvey Connolly and Emily Keane.
M.Eng.in Logistics

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Hephner, Richard H. ""Where Youth and Laughter Go:" Trench Warfare from petersburg to the Western Front." Thesis, Virginia Tech, 1997. http://hdl.handle.net/10919/36824.

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The study of soldier’s experience is important to understanding the effect that wars have on society. In the latter part of the 19th century the experience of warfare changed due to advances in weapons technology. The defensive tactic of trench warfare gained new importance. The most prolific use of trench warfare occured on the Western Front in the First World War, but it was during the siege of Petersburg in the American Civil War that extensive trenches were first used with technologically advanced weapons. By comparing the siege of Petersburg with the Western Front, it is clear that similar conditions elicited similar emotional reactions from soldiers. The most common reactions were fraternization and war neurosis. Fraternization was more prevelant during the siege of Petersburg than at other times during the war. Fraternization was also common on the Western Front. The reasons for this vary, but are all linked to the nature of trench warfare. War neurosis was also caused by the conditions of the trenches. It was a bigger problem at Petersburg and on the Western Front than it was for soldiers in other conflicts. Trench warfare created these emotional reactions.
Master of Arts

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Sakadakis, Stella. ""Where do the boys go?" : tracking the development of careers in the music industry." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55453.

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Musical careers develop along particular trajectories as a consequence of the relationships that are established between the musician and the industry. This thesis studies the nature of these relationships and the manner in which they contribute to the development of a musical career. The dichotomy between the artistic concerns of the musician and the economic interests of the industry that informs many popular music studies is re-oriented in light of the economic interests that are inherent in the musician's pursuit of a musical livelihood. The importance of commercial success in the maintenance of a musical living is explored in the case study of Men Without Hats, a Montreal based pop band that has maintained a fifteen year career despite a lack of commercial success over the past decade. This study suggests that the maintenance of a musical career over an extended period of time is a consequence of the types of relationships that are cultivated by the musician over the course of his/her career.

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Attridge, Michael. "The Eucharist in Anglican/Roman Catholic international dialogue, where do we go from here?" Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq25196.pdf.

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Hart, Susan Quincie. "Finding the place where poets go, an interpretive inquiry of aesthetic experience through poetry." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0014/NQ59966.pdf.

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Wellington, Yuriko Carol. "To know, to care, and to act. Multiculturalism: Where do we go from here?" Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/280224.

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This study explored the multicultural nature of the curriculum in the Department of Culture and Literacy Studies, an interdisciplinary graduate program in education at a major research institution in the Southwest United States. Initiated in response to my own experiences of cultural discontinuity as a student in the department and fueled by reports of similar experiences from other foreign and minority colleagues, the study considered the notion of multiculturalism in academia from several different perspectives. First, it used traditional process/product methodology to quantitatively and qualitatively analyze the content of course syllabi, texts and other resources. Second, it used the phenomenological process of focused life histories to look closely at the extent to which culture and history impact a student's perception and experience of a multicultural curriculum. Third, the study explored Slaughter's (1997) suggested relationship of social movement theory to post-secondary curriculum development by linking the themes emerging from the narrative professional life histories of professors to concepts and practices reflected in their course syllabi. The study sought to situate the multicultural CLS curriculum within the larger social context with which it interacted, and examine its impact from the multiple perspectives of faculty, students, and institutional curricular structures. I established a theoretical framework for this study's examination of multicultural education curriculum with three major dimensions: content, process and orientation. The results of this study provide a basis for understanding the impact of the prior experiences of teachers and students in constructing and responding to curriculum, and may be used to inform departmental policy and classroom practices in university classrooms. The study particularly contributes to curriculum studies by bridging the fields of higher education and multicultural education, by offering a new way of looking at curriculum and curricular practices, and by providing new evaluation criteria that others can use to examine the impact of curriculum and curricular practices on teaching and learning.

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Ahlberg, Oscar. "Where did they go? : An explorative study on the marketplace absence of elderly consumers." Thesis, Uppsala universitet, Företagsekonomiska institutionen, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-386286.

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This thesis will explore the complex relationship between marketplace exclusion and symbolic resources mediated by the market, for older consumers who have traversed from a socio-cultural identity in the majority to stand on the periphery of consumption. Employing a Consumer Culture Theory influenced perspective and using Baudrillard critical theory of symbolic exchange and death as a lens of analysis, this thesis will utilize a psycho-social method to explore how and why older consumers find themselves excluded from the market. As well as how this absence is negotiated in a society where inclusion in social life is dependent on consumption. This thesis postulates the market as an ideological structure that promulgates a capitalist ideology of life as an affirmatory force and, therefore, negates death. In doing so this thesis problematizes the dominant notion of the market in theory and practice, in particular, the notion of the market as a free and open space for participation. Contributing to an explorative effort to shed light on the complex relationship between exclusion and sign-value, marketplace representation and ideology.

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Hughes, Erik-Logan. "Where did the green jobs go? : a case study of the Boston metropolitan region." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/117827.

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Thesis: M.C.P., Massachusetts Institute of Technology, Department of Urban Studies and Planning, 2018.
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis. "June 2018."
Includes bibliographical references (pages 95-102).
The green jobs movement was a part of a nation-wide effort to address economic injustice while also directly contributing to the preservation or enhancement of environmental quality in America's urban centers. Attempts to realize the movement were seeded largely through American Recovery and Reinvestment Act funding, at a time when the United States was facing its greatest economic recession since the Great Depression. With high hopes, urban governments organized and implemented green workforce development programs with the vision of creating family-supporting, career pathways that would help address the challenges of climate change. This thesis, through the use of semi-structured interviews, analyzes how the green jobs movement began and ended in the Boston metropolitan region. My findings support that the primary reasons for the collapse of green workforce development programs were that cooperation between organizations was minimal, which resulted in duplicate programs or programs that were never fully realized. Additionally, my findings support the conclusion discussed in the literature that green jobs do not constitute a separate classication of work. Finally, the green jobs movement was not capable of alleviating the stress placed on the Bostonian labor supply by the Great Recession beginning in late 2008 and ending in 2012. The conclusion of the case study is not that the green-collar economy cannot be realized in the Boston metropolitan region. Instead, the summary findings are that progress was made towards achieving sustainable development goals, propelled predominantly by the success of the clean energy industry and the emergence of municipal energy functions. Policymakers who wish to support the growth of the green-collar economy and sustainability can do so through more coordinated efforts, utilizing the groundwork laid by the green jobs movement.
by Erik-Logan Hughes.
M.C.P.

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Lam, Fred, and Ali Bokhari. "New Onset Hypoglycemia in Non-diabetic Adult Patients: Where Do We Go from Here?" Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/asrf/2020/presentations/55.

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Background: Hypoglycemia is a commonly encountered metabolic state in the patient population. It can be medically defined as a blood sugar <70mg/dL in a diabetic patient or <50mg/dL in a non-diabetic patient. It is less frequently seen in non-diabetics due to the body’s ability to autoregulate insulin administration. Common symptoms are sweating, tremors, palpitations, dizziness, drowsiness, and confusion. If left untreated, these symptoms can progress to seizures, arrythmias, or other complications that ultimately lead to death. Objective: To highlight the possible causes of hypoglycemia and the appropriate work-up for normally euglycemic patients. Case Description: We herein report a case of hypoglycemia in a 36-year-old female with Lupus related end-stage renal disease on hemodialysis via Ash-catheter who presented with peritonitis due to a defunct peritoneal dialysis catheter. The patient was found to be bacteremic; therefore both catheters were removed and antibiotics were started. Repeat blood cultures showed no growth for 48 hours, so the patient was held fasting at midnight for placement of a new catheter. On the day of surgery, she registered multiple blood sugar readings as low as 15mg/dL. Her symptoms were limited to drowsiness and shortness of breath. She was given four D50 boluses, glucagon IV, and a D5 drip that was adjusted to a D15 drip to stabilize her blood sugar. It was discovered that at an admission two months ago, the patient had a few readings in the 30s. She denied any recollection of this and claimed to have been asymptomatic. She also denied a history of low blood sugars and a diagnosis of diabetes. In surgery that day, the patient went into cardiac arrest on the operating table after being sedated. She was resuscitated after one round of chest compressions, and her catheter was placed. During the episodes of low blood sugar, specific labs were drawn for the work-up of hypoglycemia (glucose, insulin, C-peptide, proinsulin, beta-hydroxybutyrate, insulin antibodies, and sulfonylurea/meglitinide screen), but results yielded inconclusive values that prevented a diagnosis. The patient’s blood sugars became steady once her diet was restarted, and she was discharged in stable condition to a rehab facility after cautionary counseling was given. Discussion: This case highlights an optimal way to work-up a patient with new onset hypoglycemia, focusing on patient history and drawing the appropriate labs during hypoglycemic episodes. The specific labs listed above can be used to differentiate between various causes of hypoglycemia (exogenous insulin administration, an insulin secreting tumor [insulinoma], insulin antibodies, insufficient cortisol or glucagon levels, or improper sulfonylurea/meglitinide use) by comparing them to standards. If labs are unable to be obtained, a 72-Hour Fast can be conducted to create a controlled environment, and a Glucagon Tolerance Test can further explore if the cause of hypoglycemia is insulin related. The goal of all of this testing is to be able to identify and treat the underlying cause of the hypoglycemia and prevent future episodes and the complications that accompany it.

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Knight, Peter David, and n/a. "Where did we go wrong? : a critical assessment of management in the Bluff Oyster Fishery." University of Otago. School of Surveying, 2008. http://adt.otago.ac.nz./public/adt-NZDU20081218.160813.

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More than a century of dredging for oysters in the Foveaux Strait has resulted in a decimated fishery. In 1999 the Parliamentary Commissioner for the Environment asked the question: Where did we go wrong? This thesis provides answers to this question by presenting information provided by the Bluff oyster fishermen. In order to gain as much exposure to the community of fishermen as possible, a cumulative period of approximately six months was spent living in the town of Bluff between 2002 and 2007. During this time relationships were built with key informants, and a total of more than 50 community members were interviewed. The thesis describes the practical knowledge of the oyster fishermen, and places it in the context of more that 40 years of modem scientific studies concerned with the fishery. The finding are that since 1996 when the Quota Management System was introduced in the fishery, the most knowledgeable and responsible people in the fishery have been systematically excluded from roles in management. The practical knowledge of fishermen has been discounted in an industry and government led management system, which is an elaborate justification for continued maximum exploitation of the fishery. The theoretical contribution of the thesis lies in its description of belonging as a factor as important as that of property-rights in a sustainable resource system. The practical knowledge and conservation-mindedness of the fishery elders are characteristics of belonging, but not necessarily of ownership. Fishery management should recognize belonging as cultural capital, and make use of it under the present system (i.e. the Quota Management System) by according fishermen rights of management and access to the oyster fishery.

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Bogden, Lorree. "Where did all of the good mothers go?, the gendered nature of child custody law." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ61410.pdf.

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Redfering, Kristie Jo. "Teacher Perceptions of Violence Prevention Approaches and Self-Efficacy: Where Do We Go from Here?" NSUWorks, 2014. http://nsuworks.nova.edu/shss_dcar_etd/29.

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This research project explored teachers’ beliefs of violence prevention approaches and self-efficacy. Relevant research indicates the value of violence prevention and conflict resolution education as well as the importance of teacher support of such programs. Theories of decision-making and self-efficacy provide the foundation for the variables that were examined through use of a survey instrument developed by Dr. K. King and Dr. T. Kandakai. Participants were sampled from two Florida school districts. Independent variables included teacher background and experience indicators including demographics and teaching/training experience. Dependent variables were comprised of multiple indicators of outcome value, efficacy expectation, and outcome expectation. MANOVAs and ANOVAs were utilized to identify relationships between the independent and dependent variables. Among the statistically significant findings a theme emerged: training history including variety of training, specific topics, and the interaction effects of combinations of training impacted perceptions of self-efficacy and outcome expectation more significantly than other demographic and background characteristics. The results suggest that the provision of a variety of training for teachers may benefit violence prevention practice by increasing perceptions of efficacy which may lead to an increase in consistent and effective utilization of various conflict resolution education programs and strategies.

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Eke, Collins U. "Where Did They Go? Analysis of Out-Migration from Mammoth Cave National Park, 1920-1940." TopSCHOLAR®, 2019. https://digitalcommons.wku.edu/theses/3111.

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The 52,830-acre Mammoth Cave National Park, located in the karst region of south-central Kentucky, was formally established in July of 1941, culminating nearly three decades of park creation that displaced several thousand residents of the region. This thesis sampled residents using the 1920 manuscript census for the United States Census of Population and Housing and tracked their migration destinations using the 1930 and 1940 manuscript censuses. Migration patterns for the entire sample, as well as by race and homeownership status, were identified through mapping. Out-migrants generally chose locations north, west, and east of the proposed park area, noticeably neglecting the Deep South. Statistical analyses proved significant differences between proportions of Black out-migrants and White out-migrants moving to urban areas, as well as those of homeowners and renters who were not successfully tracked during analysis. The research underlines unintended consequences of the forced out-migration from the proposed Mammoth Cave National Park and several factors that contributed to it. In the process, the thesis fills a gap in research on Mammoth Cave National Park and sheds light on an important aspect of Kentucky’s history.

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Masséus, Jonatan. "Where Did The Car Go? : Smart cities, calm technology and the future of autonomous cars." Thesis, Internationella Handelshögskolan, Jönköping University, IHH, Informatik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-50202.

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Urbanization has been a growing trend in the past fifty years. Cities are now transforming into smart cities, spaces whose infrastructure comprises an embedded digital layer. Hardware collects real-time data in the urban environment and software elaborates it to improve all types of services, from traffic to waste management to well-being. One technology that is expected to use this digital layer to further change the urban environment is the autonomous car. The purpose of this dissertation is to explore what key design attributes future autonomous cars should possess if they have not only to co-exist with and be accepted by people in the landscape of tomorrow’s smart cities, but also what they should not possess in order not to cause any harm. In this sense, the dissertation recognizes calm technology to be necessary in the design of a future autonomous car to support a human-centered, as opposed to a car- or technology-centered, environment. A socio-technical and systemic lens is applied to the phenomenological investigation of nine companies carried out by means of twelve in-depth semi-structured interviews with experts working within the automotive sector, the smart city industry, and calm technology. Eight attributes (safety, on-demand, geo-tracking, sharing, multiple purposes, communication through smart devices, electrical care and IoT/connectedness) are identified as necessary for future autonomous cars to implement in order to take advantage of the smart city infrastructure and provide a human-centered experience. Additionally, six out of the eight calm technology principles recognized in literature are considered necessary when designing future autonomous cars.

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Lovoll, Andrea K. ""Where Do We Go From Here?" Teaching a Generation of Nclb Students in College Classrooms." Thesis, University of North Texas, 2013. https://digital.library.unt.edu/ark:/67531/metadc271859/.

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Since the passing of No Child Left Behind Act in 2001, the United States' secondary education system has undergone significant changes. In this study, I discuss the ways in which the law has encouraged the normalization of standardized testing and aim to answer two primary research questions. RQ1: What do college students and their instructors identify as the key challenges that arise as students educated under NCLB begin college coursework, and how does each group address these challenges? RQ2: What strategies do the actors and spect-actors in a Forum Theatre production arrive at for addressing the challenges faced by college instructors and their students who have completed their secondary education under No Child Left Behind? To answer the initial research question, I conducted focus group interviews with instructors and students at the University of North Texas to understand the challenges each faces in the classroom. To answer the second research question, I compiled narratives from the focus group interviews along with other materials into a performance script that concluded with scenarios based in Augusto Boal's Forum Theatre techniques. In live performance events audience members rehearsed strategies for addressing the challenges that instructors and students face in classrooms through performance. Following descriptions of the performances, I analyze the scenarios through theories of Michel Foucault and Paulo Freire, to understand the productive power of the banking model reflected in the suggestions from the audience.

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Jönsson, Sara, and Linda Lagerdahl. "Swedish Music and Fashion - a Global Passion? : Swedish Gorn Globals: Where do they go and why?" Thesis, Stockholm University, School of Business, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-6117.

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This Master Thesis discusses the phenomenon of Born Globals, i.e. companies which internationalise at an early stage and view the whole world as their playing field. Most definitions of Born Globals only regard the international output of a company. We have chosen to consider the international input as well. The definition of Born Globals used in our study is: ´a firm that from its inception derives competitive advantages from the use of resources and the sales of outputs in multiple countries´. These are the research questions: 1. Which countries/markets do the Swedish Born Globals trade in, input and output? 2. Why have the companies entered these countries/markets? 3. Does culture influence the decision of which countries/markets to go into? How? A purpose of this thesis is to contribute new knowledge within this subject. And since most research about Born Globals has been focused on the high-technology sector, we have as an alternative, selected two industries within the Experience Economy; music and fashion. We examined research question number 1 through a quantitative process; a telephone survey including ten Swedish Born Global companies from each industry. Furthermore, we approached research questions 2 and 3 through a qualitative manner using in-depth interviews with two companies from each industry. Theories chosen for this thesis are: the Uppsala School, the Transaction Cost Analysis, the Network, the Born Global, the Social Capital, the Marker Size, the Push and Pull and the Country Cluster theories. In conclusion, the largest output countries for the music business are Germany, the U.S., Japan and England. On the input side, the most common markets are England/UK, the U.S. and Germany. In the fashion business, the most common markets for output are Denmark, Norway, Finland, Germany, England/UK, Greece and Japan. The largest markets for input are Portugal, Italy and China. The music companies put forward a number of reasons for the most common output markets: openness to new music, large market potential, geographical closeness, similar music style, contacts and the use of a country as a “springboard” to enter other markets. The fashion companies gave a number of reasons for the most common output markets: geographical and cultural proximity, networks and similar fashion style. Reasons on the input side are: history in textile manufacturing, flexibility, quality, contacts, networks, coincidence, reputation and low cost. All respondents agreed that culture influences the decisions of which countries to enter as well as which markets to stay away from. In the Final Discussion we have presented an inductive model called the Born Global Four-Fielder. This model considers the international input and output sides equally important.

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Jones, Michael L. W. "Where do you want to go tomorrow?, shaping alternative technological futures via ethnographically informed participatory design." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape15/PQDD_0020/MQ37559.pdf.

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Gill, Kimberly Deanna Gryski Gerard S. "What you know or where you go political cultural analysis of gender stereotyping and leadership positions /." Auburn, Ala., 2009. http://hdl.handle.net/10415/1693.

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Rus, Katerina. "Where do they go? : A study of university academics who choose not to be on Facebook." Thesis, Högskolan i Borås, Akademin för bibliotek, information, pedagogik och IT, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-12943.

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This study will look at a group of people not often researched and neglected by organisations; those who actively choose to stay off the social networking site Facebook. The aim is to find out the reasoning behind why a particular group, that is information science university academics, choose to stay off Facebook. This group represents an intellectual part of society who possesses specific knowledge of what it entails to be a member of Facebook as far as security and personal integrity is concerned.The aim is to find out what reasoning is behind their active choice, whether it is a security issue or merely a choice to do other things with one´s private time. Theories examined deal with how a person's background, values, trust issues and education can influence the choices he or she makes regarding Facebook.The study subjects were asked the same questions during a research interview, with the main question being “why are you not on Facebook”. The results of the interviews were analysed and each person was sorted under one or several categories: Idealists, pragmatists, sceptics and technocrats.Pragmatists were the most represented, typically people who consider Facebook a waste of time and prefer to meet people in real life rather than online.The study showed that all inactives use Internet for emailing and research; some use it to indulge their personal interests. Being part of a professional group that works with media related topics gives this group both an insight on security issues but also underlines an urge to stay offline in their private lives.

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CONDACK, MARCELO JOSE. "WHERE TO GO WHEN DOES NOT HAVE PLACE?: DESCRIPTION AND BASICS CONCEPTS OF THE FRENCH INSTITUCIONAL PSYCOTHERAPY." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2009. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=13980@1.

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COORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR
Este trabalho percorre o contexto histórico no qual surge a Psicoterapia Institucional, para em seguida definir – sob o pilar da psicanálise lacaniana – seu público alvo, e por fim, apresentar seus conceitos mais importantes. Articulando tais conceitos tanto com formulações lacanianas quanto com o cotidiano institucional. Em seu anexo, apresenta dois textos inéditos em língua portuguesa, escritos recentemente por Jean Oury.
This work covers the historical context in which the Institucional Psycotherapy appears, for after that defining - under the pillar of the psychoanalysis - its public, and finally presenting its more important concepts. Articulating such concepts in such a way with Lacan formularizations. In its annex, it presents two unknown texts in Portuguese language, writings recently for Jean Oury and others.

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Elliott, Emma. "Where Do We Go From Here? A Semi-Autobiographical Performance Exploration into the Therapeutic Benefits of Theatre." Scholarship @ Claremont, 2019. https://scholarship.claremont.edu/scripps_theses/1366.

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My intention in this performance is to create a therapeutic theatrical process for myself and engage the audience with intense emotional vulnerability regarding the combination and validation of the nobody and performative self. I utilized both my vocal and acting training to work through emotional trauma that I have experienced and created a musical performance to demonstrate my journey of therapy and emotional reconciliation within myself and my family. I focused my research on using autobiographical performances to solidify and validate the identity of the performer to an audience. In doing so, this allows the performers to become the narrator and take control of their life story. Self-reflection can provide clarity and insight into one’s mental state and understanding of how certain events have impacted them mentally and/or physically.

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Liscio, Stephanie Marie. "“If You Build It, Where Will They Go?” Sports Stadiums, Civic Pride, And Neighborhood Displacement, 1930-1970”." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1523312836501394.

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Nilsson, Emilia. "Where did the book go? - An empirical study about reading habits and reading ecologies of Swedish Kindle-users." Thesis, Malmö högskola, Fakulteten för kultur och samhälle (KS), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-22404.

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Through the introduction and popularisation of e-books and e-readers, the way books are read is changing. This paper aims to investigate the reading habits of five Swedish-based Kindle users to understand their reading ecologies and what place the Kindle has in their reading ecologies. The Kindle proves an interesting research focus as it is one of the most sold e-readers in the world, but has yet to establish itself on the Swedish market. The research focuses on three main themes: the reading ecologies and habits of the interviewees; why they use the Kindle; and how they use reviews on Kindle Store. The research uses the methods of communicative ecology mapping and qualitative interviews for collecting empirical data, which is then contextualised and analysed through the theories of communicative ecology, mediatization, and media as practice. The research shows that the interviewees prefer reading on digital devices, and that particular practices of reading are done in specific spatial dimensions. Three practices of reading are visible in the interviewees’ reading ecologies: news-reading, social media-reading, and Kindlereading. The interviewees use the Kindle as a replacement of the physical book, which is shown in the way the interviewees list the e-ink technology and lack of backlit screens as motivations for using the device, in addition to the vast amount of niched literature available on Kindle Store. Moreover, reviews on Kindle Store are valuable to the interviewees when buying books, but the type of book changes how much validity the reviews hold. The reviews, no matter if they are being read or written by the interviewees, are viewed as helping the community of readers who use Kindle in finding ‘good’ literature.

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Hodge, Cherise A. "Virginia's Instructional Technology Resource Teacher Program: Ten Years Later, What We Know, -Where Do We Need to Go?" VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4731.

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VIRGINIA’S INSTRUCTIONAL TECHNOLOGY RESOURCE TEACHER PROGRAM: TEN YEARS LATER, WHAT WE KNOW, WHERE DO WE NEED TO GO? By Cherise Ann Hodge, PhD A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2017 Director: Dr. Whitney Newcomb, Professor, Educational Leadership In 2004, Virginia’s Department of Education (VDOE) identified the need for technology integration in instruction to meet the needs of the 21st century student. For this to happen effectively, Virginia legislators authorized and funded an instructional position, the Instructional Technology Resource Teacher (ITRT), for each 1000 students in Virginia’s 132 school divisions (Virginia Standards of Quality [SOQ], 2004). The VDOE established guidelines for this position to direct school division implementation. Primary responsibilities for the position involve activities relating to teacher professional development. Virginia divisions chose varying models for deploying the ITRT to meet this requirement. In 2012, the legislature edited the directive for the position to give localities the option to use the position as an ITRT, as a data coordinator, or as both positions (Virginia Standards of Quality, 2012). This study uses survey data to determine how ITRTs are spending their time, ten years after the implementation of the program. Survey data was compared to data collected by Hooker (2006) and the guidelines for the position as published by the Virginia Department of Education (Virginia Department of Education [VDOE], 2008). Major findings indicate that ITRTs are still spending time on tasks that are not specified in the published guidelines. This study’s data correlate with the data gathered by Hooker (2006) following the first year of the implementation of the SOQ.

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Gregory, Donnelle E. "Where do we go from here? understanding the impact of racism and its influence on African-American male superintendents /." Cincinnati, Ohio : University of Cincinnati, 2006. http://www.ohiolink.edu/etd/view.cgi?acc%5Fnum=ucin1147969124.

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Thesis (Dr. of Education)--University of Cincinnati, 2006.
Title from electronic thesis title page (viewed Sept. 11, 2006). Includes abstract. Keywords: African-American Superintendent; African-American Males; Superintendents; Critical Race Theory; Leadership; African-American Administration. Includes bibliographical references.

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Raju, Ravikiran. "Where Proteins Go to Die: Elucidating the Physiological and Therapeutic Significance of the Clp Protease Complex in Mycobacterium Tuberculosis." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10501.

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Microbiologists have long focused on transcription as a main source of physiological regulation in bacterial adaptation. However, the time scale on which certain cellular responses must be coordinated dictates that a more rapid system be in place to deal with sudden environmental stresses. In eukaryotes, understanding the proteasome and ubiquitin-tagging has led to an appreciation for protein turnover as a mechanism for rapid adaptation. Like eukaryotes, bacteria possess several proteolytic complexes that degrade proteins into smaller polypeptides and amino acids. These enzymes were discovered as maintainers of protein quality control, through recognition of aberrant protein products, but recent studies have suggested that they play an active role in regulation of cell processes through degradation of endogenous proteins. Surprisingly, a genome wide screen for essential genes in Mycobacterium tuberculosis (Mtb) found numerous proteases to be essential for growth, providing evidence that degradative regulation may be critical for survival. One essential complex, Clp protease, was intriguing as it appeared to have a divergent structure in Mtb, and was largely dispensable for growth in most other organisms. In order to study the importance of protein turnover and degradative regulation in Mtb, I chose to study Clp as a model. I confirmed that Clp was required for normal growth in mycobacteria through targeted genetic engineering, and demonstrated that depletion of Clp was bactericidal. We hypothesized that a protease would be essential because it might prevent accumulation of toxic proteins or repressors of vital processes. To understand why Clp protease was so critical, I conducted proteomic analysis comparing wildtype and Clp-depleted cells to identify substrates of the protease. In line with our hypothesis, I identified WhiB1, a redox-sensitive transcriptional repressor. Blocking degradation of WhiB1 by Clp resulted in death, suggesting that the importance of Clp can be partially explained by its action on the repressor. Finally, taking advantage of known Clp-specific inhibitors in S. aureus, we showed that Clp could be targeted with small molecules in Mtb. The elucidation of novel drug targets and small molecules active against Mtb is crucial due to the overwhelming prevalence of the disease and rises in drug resistant forms.

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Dissertations / Theses on the topic 'Where to go'

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