Journal articles: 'WHF 800'

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Zhang, Wei, Bing Fu, Melinda S. Peng, and Tim Li. "Discriminating Developing versus Nondeveloping Tropical Disturbances in the Western North Pacific through Decision Tree Analysis." Weather and Forecasting 30, no. 2 (April 1, 2015): 446–54. http://dx.doi.org/10.1175/waf-d-14-00023.1.

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Abstract This study investigates the classification of developing and nondeveloping tropical disturbances in the western North Pacific (WNP) through the C4.5 algorithm. A decision tree is built based on this algorithm and can be used as a tool to predict future tropical cyclone (TC) genesis events. The results show that the maximum 800-hPa relative vorticity, SST, precipitation rate, divergence averaged between 1000- and 500-hPa levels, and 300-hPa air temperature anomaly are the five most important variables for separating the developing and nondeveloping tropical disturbances. This algorithm also unravels the thresholds of the five variables (i.e., 4.2 × 10−5 s−1 for maximum 800-hPa relative vorticity, 28.2°C for SST, 0.1 mm h−1 for precipitation rate, −0.7 × 10−6 s−1 for vertically averaged convergence, and 0.5°C for 300-hPa air temperature anomaly). Six rules are derived from the decision tree. The classification accuracy of this decision tree is 81.7% for the 2004–10 cases. The hindcast accuracy for the 2011–13 dataset is 84.6%.

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Salmeen, Kirsten, Jeanne-Marie Guise, Erika Cottrell, Aaron Caughey, and Yvonne Cheng. "805: VBAC in the US: who tries, who succeeds?" American Journal of Obstetrics and Gynecology 208, no. 1 (January 2013): S337—S338. http://dx.doi.org/10.1016/j.ajog.2012.10.143.

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Suman, Swapan. "Conversion of Solid Biomass into Biochar: Act as a Green, Eco-Friendly Energy Source and a Substitute of Fossil Fuel Inputs." Proceedings 58, no. 1 (September 11, 2020): 34. http://dx.doi.org/10.3390/wef-06916.

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To meet the global demand of energy requires an alternative source, preferably with a lower concern of climate change. Biochar production from agricultural biomass waste by pyrolysis creates a unique solution for producing a useful source of green energy. Biochar is a carbon-rich product with a high heating value which is comparable with our primary energy sources (fossil fuels). Biochar can be utilized for various purposes such as energy production and soil enhancement. Biochar can be more suitable for steelmaking, in view of their chemical and thermo-chemical characteristics including low ash, higher heating values (HHV), and high surface area. Biochar can also be utilised selectively for soil amelioration, C-sequestration, and waste water treatment, in view of the suitability of their characteristics (such as higher values of pH, mineral content, and surface area) for meeting the requirements for a particular purpose. This study associates the characteristics of biochar produced by slow pyrolysis at 800 °C for two biomass residues: corn cob and coconut shell. These results can be used to establish ideal utilization means of biomass for energy and/or biochar production.

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Antonescu, Bogdan, Tomáš Púçik, and David M. Schultz. "Hindcasting the First Tornado Forecast in Europe: 25 June 1967." Weather and Forecasting 35, no. 2 (February 25, 2020): 417–36. http://dx.doi.org/10.1175/waf-d-19-0173.1.

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Abstract The tornado outbreak of 24–25 June 1967 was the most damaging in the history of western Europe, producing 7 F2–F5 tornadoes, 232 injuries, and 15 fatalities across France, Belgium, and the Netherlands. Following tornadoes in France on 24 June, the Royal Netherlands Meteorological Institute (KNMI) issued a tornado forecast for 25 June, which became the first ever—and first verified—tornado forecast in Europe. Fifty-two years later, tornadoes are still not usually forecast by most European national meteorological services, and a pan-European counterpart to the NOAA/NWS/Storm Prediction Center (SPC) does not exist to provide convective outlook guidance; yet, tornadoes remain an extant threat. This article asks, “What would a modern-day forecast of the 24–25 June 1967 outbreak look like?” To answer this question, a model simulation of the event is used in three ways: 20-km grid-spacing output to produce a SPC-style convective outlook provided by the European Storm Forecast Experiment (ESTOFEX), 800-m grid-spacing output to analyze simulated reflectivity and surface winds in a nowcasting analog, and 800-m grid-spacing output to produce storm-total footprints of updraft helicity maxima to compare to observed tornado tracks. The model simulates a large supercell on 24 June and weaker embedded mesocyclones on 25 June forming along a stationary front, allowing the ESTOFEX outlooks to correctly identify the threat. Updraft helicity footprints indicate multiple mesocyclones on both days within 40–50 km and 3–4 h of observed tornado tracks, demonstrating the ability to hindcast a large European tornado outbreak.

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Temming, Maria. "The Man Who Wasn't There." Scientific American 313, no. 4 (September 15, 2015): 80. http://dx.doi.org/10.1038/scientificamerican1015-80b.

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Moser, Ben A., William A. Gallus, and Ricardo Mantilla. "An Initial Assessment of Radar Data Assimilation on Warm Season Rainfall Forecasts for Use in Hydrologic Models." Weather and Forecasting 30, no. 6 (November 18, 2015): 1491–520. http://dx.doi.org/10.1175/waf-d-14-00125.1.

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Abstract The effect of introducing radar data assimilation into the WRF Model to improve high-resolution rainfall forecasts that are used for flash flood forecasting is analyzed. The authors selected 12 heavy rainfall events and performed two WRF 24-h simulations that produced quantitative precipitation forecasts (QPFs) for each, one using the standard configuration in forecast mode (QPF-Cold) and one using radar data assimilated at initialization (QPF-Hot). Simulation outputs are compared with NWS stage IV QPEs for storm placement, area over threshold coverage, and equitable threat scores. The two QPF products and stage IV data are used to force the distributed hydrological model CUENCAS for the same 800 km × 800 km domain centered over Iowa (and to calculate peak flows across the river network). The hydrological model responses to the three products are compared in terms of spatial location and flood intensity. In general, QPF-Hot outperformed QPF-Cold in replicating stage IV QPE statistics. However, QPF-Hot was too wet in the first 2 h of the event, and storms created by the radar-assimilation techniques dissipated quickly, with rainfall forecasts resembling QPF-Cold after 12 h. Flash flooding predicted by CUENCAS using QPF-Hot was more consistent with stage IV in terms of placement and intensity; however, results were not consistent for all events evaluated. The most encouraging result is that expected flash flooding was indeed predicted in all 12 cases using QPF-Hot and not QPF-Cold even though placement and intensity were not a perfect match. The initial results of this study indicate that radar assimilation improves WRF’s ability to capture the character of storms, promising more accurate guidance for flash flood warnings.

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Susan, Zobaida Sultana, Afzallunnesa Chowdhury, Shipra Halder, Sabarin Ahamed, Helena Afrin, Tahmina Hossain, and Raunak Jahan. "Use of Combination of Mifepristone and Misoprostol to Terminate Early Pregnancy: Experience at a Tertiary Care Teaching Hospital." Journal of Science Foundation 15, no. 1 (August 28, 2018): 9–13. http://dx.doi.org/10.3329/jsf.v15i1.34775.

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Background: Termination of pregnancy is well prescribed method all over the world to terminate the early pregnancy with the combination of mifepristone and misoprostol tablet orally.Objective: The purpose of this present study was to determine the efficacy of mifipristone (200 mg) for medical termination of early pregnancy with oral misoprostol 800 mcg 24 hours later.Methodology: This observational study was done in the Department of Gynaecology & Obstetrics at Shaheed Suhrawardy Medical College & Hospital, Dhaka, Bangladesh among outdoor patients in 6 months period from July 2014 to December 2014. The patients with intrauterine pregnancy up to 9 weeks and blighted ovum were included. Incomplete abortion and extrauterine pregnancy were excluded. Mifepristone 200 mg followed by misoprostol 800 mg after 24 hours had been given.Result: Total 50 patients with 9 weeks of pregnancy were selected over the period of 6 months requesting termination of pregnancy. This study showed termination of early pregnancy up to 9 weeks with tablet mifepristone and tablet misoprostole which was effective as well as the expulsion rate of the product of conception was 92.0% cases and among them 32.0% patients were needed extended dose of misoprostol and 8.0% cases had incomplete abortion who needed surgical evacuation. Some patients had some complications like vomiting, fever, abdominal pain and excessive per vaginal bleeding which were managed accordingly.Conclusion: Mifepristone 200 mg followed by misoprostol 800 mcg orally is an effective method for termination early pregnancy with minimum side effects.Journal of Science Foundation 2017;15(1):9-13

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Kandel, Prakriti Raj, J. B. Sherchand, and S. Adhikari. "A STUDY OF MALARIA IN RELATION TO HIV AND SYPHILIS AMONG PATIENTS VISITING BHERI ZONAL HOSPITAL." Journal of Nepal Medical Association 42, no. 146 (March 1, 2003): 89–91. http://dx.doi.org/10.31729/jnma.800.

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ABSTRACTThe study was conducted in patients, who were febrile with signs of anaemia, splenonregaly and the classiccycle of coldness, fever peaks and sweats from January to September 2000 in Bheri Zonal Hospital, Nepal.The study aimed to find out relationship of malaria with HIV and syphilis.Two hundred and twenty three blood samples collected were processed and observed using the methods ofELISA and RPR.Among total 223 suspected risk group cases, 6 individuals were detected as HIV positive and 12 individualshad syphilis. Co-infection with malaria & HIV was detected in 2 patients and malaria with syphilis in 8patients. Similarly 2 patients were co-infected with malaria, HIV and syphilis. A small positive correlation(p<0.5) of malaria, HIV and Syphilis was detected.Key Words: Malaria, HIV, Syphilis, ELISA, RPR, Nepal.

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Vairamuthu, S., and S. Margret Anouncia. "Reconnoitering Students' Satisfaction of an Online Based Assessment System to Improve Usability using PSO: An Examination into a Problem Solving and Programming Course." Engineering, Technology & Applied Science Research 6, no. 5 (October 23, 2016): 1207–11. http://dx.doi.org/10.48084/etasr.800.

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End users’ computing environment has been consistently changing in recent years due to the major advancements of Information Technology. This work aimed to measure the level of users’ satisfaction and provide feedbacks for continuous improvement of a course offered in an academic institution. End users here were the students enrolled for the course and the faculty members who offered the same and also acted as an assessor for the assessments. All assessments were scheduled and conducted online. This study was conducted to focus on two different aspects: Measuring User satisfaction and investigating information systems measures to improve usability using nature inspired computing. For user satisfaction analysis, the study employed the Multicriteria Satisfaction Analysis. The course considered was a problem solving and programming course offered to the fresh students enrolled in the first year of the undergraduate degree program in the academic institution during 2015-2016. To identify the factors for improved usability, PSO was employed in this work.

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Pavan, N., D. Modonutti, G. Liguori, F. Barbone, and C. Trombetta. "803 Patients and prostate cancer treatment: Who chooses?" European Urology Supplements 14, no. 2 (April 2015): e803. http://dx.doi.org/10.1016/s1569-9056(15)60792-8.

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van Houts, Elisabeth. "Gender and Authority of Oral Witnesses in Europe (800–1300)." Transactions of the Royal Historical Society 9 (December 1999): 201–20. http://dx.doi.org/10.2307/3679400.

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Between 1068 and 1070 an extraordinary dispute was settled at Bonneville-sur-Touques in Normandy. Duke William, who had recently become king of England, and his wife Matilda, heard the story of a contested property at Bayeux which centred on the identity of a rented child. The story goes as follows. A man called Stephen had married a widow called Oringa by whom he had a small son (puerulus) who lived only a short while. When the boy died, Oringa substituted for him, without her husband's knowledge, the son of a woman called Ulburga at Martragny (Calvados, c. Creully), to whom she paid an annual sum of 100 solidi. Stephen made the boy his heir and left him his property. When first Oringa and then Stephen died, the boy's natural mother emerged and demanded rent from the couple's surprised relatives. The family refused to pay and Ulberga turned to Duke William and his wife Matilda. Having heard die case Duke William, in consultation with Archbishop John of Rouen, Roger of Beaumont and others, decided that an ordeal of the hot iron would be die most appropriate way to establish the truth. William and Matilda sent their chaplain Rainald to Bayeux to organise the ordeal, which took place in the monastery of Saint-Vigor in the presence of Rainald himself, two named archdeacons, Robert Insule and his wife Albereda, Euremarus of Bayeux and many otfier good men (meliores homines) of Bayeux. Ulburga emerged unscathed from the ordeal by fire and therefore her son was returned to her.

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Ali, Maisa, Faraj Alhowady, Waqar Munir, Muna Almaslamani, Abdulatif Alkhal, Zubiada Alswaidi, and Hisham Ziglam. "800. Drug-Resistant TB: An Experience From Qatar." Open Forum Infectious Diseases 5, suppl_1 (November 2018): S287. http://dx.doi.org/10.1093/ofid/ofy210.807.

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Abstract Background Drug-resistant tuberculosis (DR-TB) is an important issue for public health. This study was conducted to evaluate the characteristics, treatment outcome, and risk factors associated with 223 DR-TB cases in the State of Qatar. Methods A descriptive records-based retrospective study was conducted on patients registered at Communicable Disease Centre (CDC), Qatar to all consecutive microbiologically confirmed tuberculosis cases for the period January 2010–March 2015. Demographic and clinical data extracted included: patient’s age, sex, and country of origin; disease site (pulmonary or extra-pulmonary); presence of comorbidities, HIV/AIDS status, previous chemoprophylaxis and/or previous treatment for TB, and anti-TB drug resistance the resistance pattern of isolated mycobacteria. The sputum culture conversion rate and treatment outcome was assessed for the patient who completed their treatment in Qatar Results Of 3,301 patients with positive M. tuberculosis culture were analyzed; 223 (6.7%) were resistant to one or more first-line drugs, to isoniazid in 3.1% (n = 102), streptomycin in 1.2% (n = 41), rifampicin in 0.2% (n = 6), ethambutol in 0.15% (n = 5), and multi-drug resistance in 1.2% (n = 38) of patients. Among the resistant TB patients, more common demographic characteristics were former resident of Indian subcontinent (64.1%). A history of anti-TB treatment was not a risk factor with drug resistance in our cohort. Only 111 (49.7%) patients were tested for HIV antibodies and the results were all negative. There was significant correlation between the type of drug-resistance and CXR finding (23.3% had cavity—P = 0.019). Sputum culture conversion to negative at 2 month of therapy was 94% (n = 101), whereas 122 cases lost follow-up. The outcome of treatment was assessed for 85 resistant cases with follow-up after completion of treatment, show cure rate of 97.6%, and relapse of 2.4%. However, 137 cases (61.4% from total) they left the country before completion of therapy. Conclusion Drug-resistant TB in Qatar is influenced by migration, especially from the Indian subcontinent, where the patients were probably infected. Rapid sputum sampling performed in the early stages of the disease, patient isolation, and drug susceptibility testing should be the standard of care to avoid further transmission and improve TB control. Disclosures All authors: No reported disclosures.

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Полстовалов, Олег. "Пострадавшие от преступлений, которые по сложившейся практике не признаются потерпевшими." Всероссийский криминологический журнал 11, no. 4 (2017): 805–16. http://dx.doi.org/10.17150/2500-4255.2017.11(4).805-816.

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Winchester, Ian. "Who was Whitehead?" Interchange 36, no. 1-2 (January 2005): 1–3. http://dx.doi.org/10.1007/s10780-005-8020-6.

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Cohen, Michael R., and Judy L. Smetzer. "Ongoing Incidents Involving Fentanyl Patches are Alarming!; Insulin CONCENTRATE U-500; WHO: Dilute Vincristine in a Minibag." Hospital Pharmacy 42, no. 10 (October 2007): 884–87. http://dx.doi.org/10.1310/hpj4210-884.

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These medication errors have occurred in health care facilities at least once. They will happen again—perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them in your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the USP Medication Errors Reporting Program (MERP), which is presented in cooperation with the Institute for Safe Medication Practices. If you have encountered medication errors and would like to report them, you may call USP toll-free, 24 hours a day, at 800-233-7767 (800-23-ERROR). Any reports published by ISMP will be anonymous. Comments are also invited; the writers' names will be published if desired. ISMP may be contacted at the address shown below. Errors, close calls, or hazardous conditions may be reported through the ISMP ( www.ismp.org ) or USP ( www.usp.org ) Web sites or communicated directly to ISMP by calling 800-FAIL-SAFE or via e-mail at ismpinfo@ismp.org . ISMP guarantees the confidentiality and security of the information received and respects reporters' wishes as to the level of detail included in publications.

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Kim, Annice, Thomas Miano, Robert Chew, Matthew Eggers, and James Nonnemaker. "Classification of Twitter Users Who Tweet About E-Cigarettes." JMIR Public Health and Surveillance 3, no. 3 (September 26, 2017): e63. http://dx.doi.org/10.2196/publichealth.8060.

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Liang, Siyuan, Weilong Zhu, Feng Zhao, and Congyi Wang. "High-Efficiency Wavelet Compressive Fusion for Improving MEMS Array Performance." Sensors 20, no. 6 (March 17, 2020): 1662. http://dx.doi.org/10.3390/s20061662.

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With the rapid development of microelectromechanical systems (MEMS) technology, low-cost MEMS inertial devices have been widely used for inertial navigation. However, their application range is greatly limited in some fields with high precision requirements because of their low precision and high noise. In this paper, to improve the performance of MEMS inertial devices, we propose a highly efficient optimal estimation algorithm for MEMS arrays based on wavelet compressive fusion (WCF). First, the algorithm uses the compression property of the multiscale wavelet transform to compress the original signal, fusing the compressive data based on the support. Second, threshold processing is performed on the fused wavelet coefficients. The simulation result demonstrates that the proposed algorithm performs well on the output of the inertial sensor array. Then, a ten-gyro array system is designed for collecting practical data, and the frequency of the embedded processor in our verification environment is 800 MHz. The experimental results show that, under the normal working conditions of the MEMS array system, the 100 ms input array data require an approximately 75 ms processing delay when employing the WCF algorithm to support real-time processing. Additionally, the zero-bias instability, angle random walk, and rate slope of the gyroscope are improved by 8.0, 8.0, and 9.5 dB, respectively, as compared with the original device. The experimental results demonstrate that the WCF algorithm has outstanding real-time performance and can effectively improve the accuracy of low-cost MEMS inertial devices.

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Ringle, William M. "Who Was Who in Ninth-Century Chichen Itza." Ancient Mesoamerica 1, no. 2 (1990): 233–43. http://dx.doi.org/10.1017/s0956536100000250.

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AbstractHieroglyphic inscriptions from Chichen Itza are examined for possible light they might shed on its ethnic and political makeup during the Terminal Classic period (a.d. 800–1000). It is suggested that many of the name glyphs include patronyms known to be important at contact. This continuity of elite occupation is reinforced by decipherment of a title common to many of them ás holpop, a title also known from early colonial Spanish and Maya documents. Finally, a reading of the event of the lintel as yul is suggested. The implications of these readings suggest the genesis of at least some Late Postclassic organizational features in the Terminal Classic. Also arguing against a severe rupture of elite life at the end of the Terminal Classic is the persistence of patronyms in northern Yucatan. Colonial sources make frequent mention of migrations and invasions as the source of the distinctive art and architecture, yet if the arguments herein are correct, there was instead a remarkable stability of ruling families in northern Yucatan. Finally, the dedication of several monuments by different individuals, each having different patronyms and marked by epithets such as “holy,” suggests considerable autonomy of these lesser officials consistent with a segmentary state form of organization.

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GOLDFARB, DAVID S., PATRICIA A. MacDONALD, BARBARA HUNT, and LHANOO GUNAWARDHANA. "Febuxostat in Gout: Serum Urate Response in Uric Acid Overproducers and Underexcretors." Journal of Rheumatology 38, no. 7 (May 15, 2011): 1385–89. http://dx.doi.org/10.3899/jrheum.101156.

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Objective.Hyperuricemia of gout can arise due to either overproduction or underexcretion of uric acid. Not all available urate-lowering therapies are equally effective and safe for use in patients with renal disease. The objective of this post-hoc analysis was to determine the effectiveness of the xanthine oxidase inhibitor febuxostat in reducing serum urate (sUA) levels in gouty patients who were either overproducers or underexcretors.Methods.Gouty subjects 18 to 85 years of age with sUA ≥ 8.0 mg/dl at baseline were enrolled in a Phase 2, 28-day, multicenter, randomized, double-blind, placebo-controlled trial and randomized to receive febuxostat 40 mg, 80 mg, or 120 mg daily, or placebo. The primary efficacy endpoint was the proportion of subjects with sUA < 6.0 mg/dl at Day 28. Secondary efficacy endpoints included percentage reductions in sUA and urinary uric acid (uUA) from baseline to Day 28.Results.Of the 153 subjects, 118 (77%) were underexcretors (uUA ≤ 800 mg/24 h) and 32 (21%) were overproducers (uUA > 800 mg/24 h); baseline uUA data were missing for 3 subjects. Treatment with febuxostat led to the majority of subjects achieving sUA < 6.0 mg/dl at Day 28. Treatment with any dose of febuxostat led to significantly greater percentage reductions in uUA than that observed in the placebo group, for both underexcretors and overproducers.Conclusion.Febuxostat is a highly efficacious urate-lowering therapy in patients with gout regardless of overproduction or underexcretion status.

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Bachrach, Bernard S. "Charlemagne’s Health in ‘Old Age’: Did It Affect Carolingian Military Strategy?" Mediaevistik 32, no. 1 (January 1, 2020): 11–53. http://dx.doi.org/10.3726/med.2019.01.01.

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During the first thirty-three years of his reign as king of the Franks, i.e., prior to his coronation as emperor on Christmas day 800, Charlemagne, scholars generally agree, pursued a successful long-term offensive and expansionist strategy. This strategy was aimed at conquering large swaths of erstwhile imperial territory in the west and bringing under Carolingian rule a wide variety of peoples, who either themselves or their regional predecessors previously had not been subject to Frankish regnum.1 For a very long time, scholars took the position that Charlemagne continued to pursue this expansionist strategy throughout the imperial years, i.e., from his coronation on Christmas Day 800 until his final illness in later January 814. For example, Louis Halphen observed: “comme empereur, Charles poursuit, sans plus, l’oeuvre entamée avant l’an 800.”2 F. L. Ganshof, who also wrote several studies treating Charlemagne’s army, was in lock step with Halphen and observed: “As emperor, Charlemagne pursued the political and military course he had been following before 25 December 800.”3

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Cortes, Jorge E., Michele Baccarani, François Guilhot, Brian J. Druker, Susan Branford, Dong-Wook Kim, Fabrizio Pane, et al. "Phase III, Randomized, Open-Label Study of Daily Imatinib Mesylate 400 mg Versus 800 mg in Patients With Newly Diagnosed, Previously Untreated Chronic Myeloid Leukemia in Chronic Phase Using Molecular End Points: Tyrosine Kinase Inhibitor Optimization and Selectivity Study." Journal of Clinical Oncology 28, no. 3 (January 20, 2010): 424–30. http://dx.doi.org/10.1200/jco.2009.25.3724.

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PurposeTo evaluate the safety and efficacy of initial treatment with imatinib mesylate 800 mg/d (400 mg twice daily) versus 400 mg/d in patients with newly diagnosed chronic myeloid leukemia in chronic phase.Patients and MethodsA total of 476 patients were randomly assigned 2:1 to imatinib 800 mg (n = 319) or 400 mg (n = 157) daily. The primary end point was the major molecular response (MMR) rate at 12 months.ResultsAt 12 months, differences in MMR and complete cytogenetic response (CCyR) rates were not statistically significant (MMR, 46% v 40%; P = .2035; CCyR, 70% v 66%; P = .3470). However, MMR occurred faster among patients randomly assigned to imatinib 800 mg/d, who had higher rates of MMR at 3 and 6 months compared with those in the imatinib 400-mg/d arm (P = .0035 by log-rank test). CCyR also occurred faster in the 800-mg/d arm (CCyR at 6 months, 57% v 45%; P = .0146). The most common adverse events were edema, gastrointestinal problems, and rash, and all were more common in patients in the 800-mg/d arm. Grades 3 to 4 hematologic toxicity also occurred more frequently in patients receiving imatinib 800 mg/d.ConclusionMMR rates at 1 year were similar with imatinib 800 mg/d and 400 mg/d, but MMR and CCyR occurred earlier in patients treated with 800 mg/d. Continued follow-up is needed to determine the clinical significance of earlier responses on high-dose imatinib.

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Mphambane, Mariah. "Who am I?" Reproductive Health Matters 9, no. 17 (January 2001): 192. http://dx.doi.org/10.1016/s0968-8080(01)90023-0.

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ARUGUETE, MARA S. "PARTICIPANTS' RATINGS OF MALE PHYSICIANS WHO VARY IN RACE AND COMMUNICATION STYLE." Psychological Reports 91, no. 7 (2002): 793. http://dx.doi.org/10.2466/pr0.91.7.793-806.

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Oh, Min Chul, Eui Hyun Kim, and Sun Ho Kim. "Coexistence of intracranial aneurysm in 800 patients with surgically confirmed pituitary adenoma." Journal of Neurosurgery 116, no. 5 (May 2012): 942–47. http://dx.doi.org/10.3171/2011.12.jns11875.

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Object The purpose of this study was to assess factors associated with intracranial aneurysm (IA) in patients with pituitary adenoma (PA). In addition, these patients were compared with a control group from the general patient population in terms of the age-matched prevalence rate and the pattern of distribution of IA. Methods The authors retrospectively reviewed 800 patients who received transsphenoidal surgery for PA and 3850 control patients from the general patient population who were evaluated for routine health care at the authors' institution between 2004 and 2010. All patients underwent MR imaging and MR angiography. Hormone assessment and pathological examination performed using immunohistochemical (IHC) staining were completed for patients with PA. Results Coexistence of IA in patients with PA was detected in 18 patients (2.3%). Multivariate analysis showed that age (p = 0.04) and cavernous sinus invasion (p < 0.001) were correlated with the increased incidence of IA, but hormone type, IHC staining, and sex were not associated. An age-matched comparison of the prevalence of IA showed an increased prevalence in patients with PA compared with the controls (p = 0.014), and when categorized according to age by decade, the 6th decade was significantly different (p = 0.039). However, the intracranial distribution pattern of IA did not demonstrate a significant difference. Conclusions Older age and the existence of a cavernous sinus invasion were correlated with increased incidence of IA in patients with PA. An age-matched comparison showed an increased incidence of IA in patients with PA than in the controls.

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Boomgaard, Peter. "Land Rights and the Environment in the Indonesian Archipelago, 800-1950." Journal of the Economic and Social History of the Orient 54, no. 4 (2011): 478–96. http://dx.doi.org/10.1163/156852011x611337.

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Abstract This article has two basic aims. First, I discuss several notions regarding long-term changes in land-tenure arrangements, mainly in what is now Indonesia. I argue that the character of these changes is often badly understood, partly because the older literature has been misrepresented, partly because the older literature was wrong, and partly because many scholars implicitly or explicitly appear to believe in “stages theories” (best known among scholars under the German term Stufentheorie), which posit fairly uniform and unidirectional stages of land-tenure development across the board. Second, this article deals with environmental causes and effects of long-term land-tenure developments in the Indonesian Archipelago. Land tenure and conservation are hotly debated at present, but the historical substance in such debates is meagre, usually going back no further than the 1950s or 60s. Nor does there seem to be much interest in the environmental roots of land-tenure arrangements, perhaps because the participants in the land-tenure-and-the-environment debate are mainly anthropologists and environmentalists, who might find such topics of antiquarian importance only. As an historian I cannot share this view.

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Bartoletti, Riccardo, Mauro Gacci, Fabrizio Travaglini, Enrico Sarti, and Cesare Selli. "Intravesical Migration of AMS 800 Artificial Urinary Sphincter and Stone Formation in a Patient Who Underwent Radical Prostatectomy." Urologia Internationalis 64, no. 3 (2000): 167–68. http://dx.doi.org/10.1159/000030521.

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Herren, Michael W. "The transmission and reception of Graeco-Roman mythology in Anglo-Saxon England, 670–800." Anglo-Saxon England 27 (December 1998): 87–103. http://dx.doi.org/10.1017/s0263675100004816.

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Rhetoricians, orators, and public speakers of all stripes, if asked the question, which Greek or Roman deity they should invoke in case of need, would surely answer ‘Hermes’ or ‘Mercury’. Members of this profession who also read early Latin-Old English glossaries might therefore be surprised to learn that the deus oratorum was none other than Priapus! This came as good news to me as one who occasionally looks for novel ways to arouse an audience. However, as I reflected further on the meaning of Épinal Glossary 10v32, my expectations wilted. Oratorum must be a simple error for hortorum, ‘of gardens’. Priapus may be fecundus, but he is not facundus.

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Vidhya, Muthuramalingam. "Lactate dehydrogenase as surrogate marker of preeclampsia and eclampsia." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 5 (April 28, 2020): 1924. http://dx.doi.org/10.18203/2320-1770.ijrcog20201781.

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Background: Hypertensive disorders of pregnancy is a spectrum of disorder which include chronic hypertension that antedates pregnancy and gestational hypertension or pre-eclampsia that is unique to human pregnancy. It is still a poorly understood condition. The clinical course is progressive and characterized by continuous deterioration that is arrested only by termination of pregnancy. Hence the disease must be detected in early stage and managed appropriately for improved maternal and fetal outcome.Methods: The study consists of 173 antenatal patients of gestational age 28 weeks and above. Study population was divided into two groups, Group 1 consists of 50 antenatal women of normotensive nature served as controls and group 2 consists of 123 antenatal women with confirmed hypertension. Venous blood samples were collected used for the estimation of lactate dehydrogenase enzyme.Results: Out of the total 173 patients 104 women delivered by C-section, 67 by normal vaginal delivery and 2 by assisted breech delivery. Among the women who delivered by caesarean 60 (57.69%) had serum LDH less than 600, 18 (17.30%) had serum LDH between 600 and 800 and 26 (25.00%) had LDH above 800. Among the women who delivered vaginally 61 (91.04%) had LDH less than 600, 1 (1.49%) had LDH between 600 and 800 and 5 (7.46%) had LDH above 800. Only 2 women delivered by assisted breech delivery one with LDH between 600 and 800 and another with S. LDH above 800.Conclusions: The study was done in search of a valuable marker for preeclampsia and Eclampsia which would reflect the severity of the disease and would predict the maternal and fetal outcome. Such markers can help in decision making and can influence the current management protocols in order to achieve a better maternal and perinatal outcome.

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Smith, Tamara, Leigh-Anne H. Krometis, Charles Hagedorn, Annie H. Lawrence, Brian Benham, Erin Ling, Peter Ziegler, and Susan West Marmagas. "Associations between fecal indicator bacteria prevalence and demographic data in private water supplies in Virginia." Journal of Water and Health 12, no. 4 (May 29, 2014): 824–34. http://dx.doi.org/10.2166/wh.2014.026.

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Over 1.7 million Virginians rely on private water sources to provide household water. The heaviest reliance on these systems occurs in rural areas, which are often underserved with respect to available financial resources and access to environmental health education. This study aimed to identify potential associations between concentrations of fecal indicator bacteria (FIB) (coliforms, Escherichia coli) in over 800 samples collected at the point-of-use from homes with private water supply systems and homeowner-provided demographic data (household income and education). Of the 828 samples tested, 349 (42%) of samples tested positive for total coliform and 55 (6.6%) tested positive for E. coli. Source tracking efforts targeting optical brightener concentrations via fluorometry and the presence of a human-specific Bacteroides marker via quantitative real-time polymerase chain reaction (qPCR) suggest possible contamination from human septage in over 20 samples. Statistical methods implied that household income has an association with the proportion of samples positive for total coliform, though the relationship between education level and FIB is less clear. Further exploration of links between demographic data and private water quality will be helpful in building effective strategies to improve rural drinking water quality.

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Gotay, Carolyn Cook, Patti Isaacs, and Ian Pagano. "Quality of life in patients who survive a dire prognosis compared to control cancer survivors." Psycho-Oncology 13, no. 12 (2004): 882–92. http://dx.doi.org/10.1002/pon.808.

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Stanley, Julian C. "Some Characteristics of SMPY's "700-800 on SAT-M Before Age 13 Group": Youths Who Reason Extremely Well Mathematically1." Gifted Child Quarterly 32, no. 1 (January 1988): 205–9. http://dx.doi.org/10.1177/001698628803200104.

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Graber Neufeld, Doug, Bernard Muendo, Joseph Muli, and James Kanyari. "Coliform bacteria and salt content as drinking water challenges at sand dams in Kenya." Journal of Water and Health 18, no. 4 (July 10, 2020): 602–12. http://dx.doi.org/10.2166/wh.2020.192.

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Abstract Sand dams can be an effective community-scale solution to increasing water supplies in some arid and semi-arid regions, but there are few studies that have investigated water quality at sand dams. This study investigated the levels of coliform bacteria and salt content as parameters of potential concern. Most water taken from sand dam sources had fecal coliforms present. Median fecal coliforms were in the range of 150–800 cfu/100 ml for unprotected sources (scoop holes, surface water or hand dug wells), levels which are considered high or very high health risk. Pump wells had less contamination, with fecal coliforms detected in one-third of samples in the dry season. Despite this contamination, user surveys indicated that 74% of communities generally view water as clean for drinking, and 72% reported that no or few people in their community treat their water. Salt content in the dry season was in the poor or unacceptable range (above 900 ppm as total dissolved solids) in 33% of water samples. Results suggest that fecal coliforms and salt content represent two types of challenges to water quality at sand dams: fecal coliforms are a health hazard, whereas high salt content potentially reduces the amount of usable water that is available.

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Yount, J. David. "FORUM: Biophysical assessments: who cares?" Ecological Economics 29, no. 1 (April 1999): 19–21. http://dx.doi.org/10.1016/s0921-8009(98)00073-1.

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Dyck, Carmen. "Who cares for the caregiver?" Parkinsonism & Related Disorders 15 (December 2009): S118—S121. http://dx.doi.org/10.1016/s1353-8020(09)70796-5.

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Wick, Gary A., Paul J. Neiman, F. Martin Ralph, and Thomas M. Hamill. "Evaluation of Forecasts of the Water Vapor Signature of Atmospheric Rivers in Operational Numerical Weather Prediction Models." Weather and Forecasting 28, no. 6 (December 1, 2013): 1337–52. http://dx.doi.org/10.1175/waf-d-13-00025.1.

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Abstract The ability of five operational ensemble forecast systems to accurately represent and predict atmospheric rivers (ARs) is evaluated as a function of lead time out to 10 days over the northeastern Pacific Ocean and west coast of North America. The study employs the recently developed Atmospheric River Detection Tool to compare the distinctive signature of ARs in integrated water vapor (IWV) fields from model forecasts and corresponding satellite-derived observations. The model forecast characteristics evaluated include the prediction of occurrence of ARs, the width of the IWV signature of ARs, their core strength as represented by the IWV content along the AR axis, and the occurrence and location of AR landfall. Analysis of three cool seasons shows that while the overall occurrence of ARs is well forecast out to a 10-day lead, forecasts of landfall occurrence are poorer, and skill degrades with increasing lead time. Average errors in the position of landfall are significant, increasing to over 800 km at 10-day lead time. Also, there is a 1°–2° southward position bias at 7-day lead time. The forecast IWV content along the AR axis possesses a slight moist bias averaged over the entire AR but little bias near landfall. The IWV biases are nearly independent of forecast lead time. Model spatial resolution is a factor in forecast skill and model differences are greatest for forecasts of AR width. This width error is greatest for coarser-resolution models that have positive width biases that increase with forecast lead time.

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Hai, Ooi See, Azizan Abu Samah, Sheeba Nettukandy Chenoli, Kumarenthiran Subramaniam, and Muhammad Yunus Ahmad Mazuki. "Extreme Rainstorms that Caused Devastating Flooding across the East Coast of Peninsular Malaysia during November and December 2014." Weather and Forecasting 32, no. 3 (April 6, 2017): 849–72. http://dx.doi.org/10.1175/waf-d-16-0160.1.

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Abstract During the early boreal winter (northeast) monsoon (November–December), cold air frequently bursts out from intense Siberian highs toward the Chinese coast in response to the development and movement of a 500-hPa trough. The resultant strong low-level northwesterlies turn into northeasterlies across the South China Sea as “cold surges.” On interacting with the near-equatorial trough, mesoscale convective systems form north of the trough, normally giving rise to heavy downpours and severe flooding, mainly along the coastal stretch in the east coast states of Peninsular Malaysia. In November 2014, a 1-week-long episode of heavy downpours, producing more than 800 mm of rain, occurred along the coastal stretch of northeastern Peninsular Malaysia. However, during December 2014, two episodes of extreme rainfall occurred mostly over inland and mountainous areas of the east coast of Peninsular Malaysia, in particular across its northern sector. These two unusual events, which lasted a total of 11 days and delivered more than 1100 mm of precipitation, resulted in extreme and widespread flooding, as well as extensive damage, in many inland areas. Analysis shows that the stronger wind surges from the South China Sea due to very intense cold-air outbreaks of the Siberian high developed under ENSO-neutral conditions. In addition, the mesoscale convective systems that developed across the northeastern Indian Ocean (near northern Sumatra) in response to the propagation of a 500-hPa short-wave trough across the Indian subcontinent toward China were the combined factors for these unusual extreme rainfall and flooding events along the east coast of Peninsular Malaysia.

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Li, Qinglan, Zenglu Li, Yulong Peng, Xiaoxue Wang, Lei Li, Hongping Lan, Shengzhong Feng, Liqun Sun, Guangxin Li, and Xiaolin Wei. "Statistical Regression Scheme for Intensity Prediction of Tropical Cyclones in the Northwestern Pacific." Weather and Forecasting 33, no. 5 (September 27, 2018): 1299–315. http://dx.doi.org/10.1175/waf-d-18-0001.1.

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Abstract This study proposes a statistical regression scheme to forecast tropical cyclone (TC) intensity at 12, 24, 36, 48, 60, and 72 h in the northwestern Pacific region. This study utilizes best track data from the Shanghai Typhoon Institute (STI), China, and the Joint Typhoon Warning Center (JTWC), United States, from 2000 to 2015. In addition to conventional factors involving climatology and persistence, this study pays close attention to the land effect on TC intensity change by considering a new factor involving the ratio of seawater area to land area (SL ratio) in the statistical regression model. TC intensity changes are investigated over the entire life-span, over the open ocean, near the coast, and after landfall. Data from 2000 to 2011 are used for model calibration, and data from 2012 to 2015 are used for model validation. The results show that the intensity change during the previous 12 h (DVMAX), the potential future intensity change (POT), and the area-averaged (200–800 km) wind shear at 1000–300 hPa (SHRD) are the most significant predictors of the intensity change for TCs over the open ocean and near the coast. Intensity forecasting for TCs near the coast and over land is improved with the addition of the SL ratio compared with that of the models that do not consider the SL ratio. As this study has considered the TC intensity change over the entire TC life-span, the proposed models are valuable and practical for forecasting TC intensity change over the open ocean, near the coast, and after landfall.

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Saarela, Tuula, and Ritva Engeström. "Reported differences in management strategies by primary care physicians and psychiatrists in older patients who are depressed." International Journal of Geriatric Psychiatry 18, no. 2 (February 2003): 161–68. http://dx.doi.org/10.1002/gps.805.

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Piperdi, Bilal, Allen Lee Cohn, Anthony B. El-Khoueiry, Jean-Francois Geschwind, Pierre Michel Gholam, Parvez Mantry, Robert C. G. Martin, et al. "Potential factors influencing initial sorafenib dose selection in hepatocellular carcinoma (HCC): U.S. regional analysis of GIDEON." Journal of Clinical Oncology 32, no. 3_suppl (January 20, 2014): 304. http://dx.doi.org/10.1200/jco.2014.32.3_suppl.304.

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304 Background: GIDEON is a global, prospective, noninterventional study to evaluate sorafenib (SOR) safety under real-life practice conditions. Here we examine potential factors that may have had an impact on initial SOR dose (ID) selection in the U.S. cohort of GIDEON. Methods: Patients (pts) with unresectable HCC who were candidates for systemic therapy and for whom a decision was made to treat with SOR were eligible for inclusion. ID choice was at physician discretion. Baseline characteristics were analyzed for their potential impact on the choice of ID. Adverse events (AEs) were evaluated by ID. All results are descriptive. Results: 563 pts were valid for safety. 54% of pts received the recommended ID of 800 mg/d, 35% received 400 mg/d, and 11% other (includes 100, 200, 600 mg/d. dose). Among pts who had an ID <800 mg/d, 37% underwent a dose increase to 800 mg/d. ID did not appear to differ by baseline Child-Pugh or its components, BCLC stage, etiology, or body mass index. By ECOG performance status (PS), IDs of 800/<800 mg/day were given as follows: PS ≤1: 55%/45%; PS ≥2: 44%/56%. By age, corresponding values were 57%/42% for <75 yr; 33%/67% for ≥75 yr. The incidence of AEs was similar across dose levels (Table). Conclusions: Baseline liver function, tumor stage, and etiology did not seem to have an influence on ID selection. We observed a trend toward lower ID in pts with age ≥75 yr and PS ≥2. Despite differences in average daily dose and time on drug, the safety profile for each ID was similar and dose adjustments may have contributed. Additional analyses are being evaluated to assess these and other contributing factors. Clinical trial information: NCT00812175. [Table: see text]

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Lodder, W. J., H. H. J. L. van den Berg, S. A. Rutjes, M. Bouwknegt, J. F. Schijven, and A. M. de Roda Husman. "Reduction of bacteriophage MS2 by filtration and irradiation determined by culture and quantitative real-time RT–PCR." Journal of Water and Health 11, no. 2 (April 18, 2013): 256–66. http://dx.doi.org/10.2166/wh.2013.204.

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Molecular methods are increasingly applied for virus detection in environmental samples without rendering data on viral infectivity. Infectivity data are important for assessing public health risks from exposure to human pathogenic viruses in the environment. Here, treatment efficiencies of three (drinking) water treatment processes were estimated by quantification of the indicator virus bacteriophage MS2 with culture and real-time reverse transcription polymerase chain reaction (qRT–PCR). We studied the virus reduction by slow sand filtration at a pilot plant. No decay of MS2 RNA was observed, whereas infectious MS2 particles were inactivated at a rate of 0.1 day−1. Removal of MS2 RNA and infectious MS2 particles was 1.2 and 1.6 log10-units, respectively. Virus reduction by UV and gamma irradiation was determined in laboratory-scale experiments. The reduction of MS2 RNA based on qRT–PCR data was negligible. Reduction of infectious MS2 particles was estimated at 3.0–3.6 log10-units (UV dose up to 400 or 800 J/m2) and 4.7–7 log10-units (gamma dose up to 200 Gray). As shown in this study, estimations of viral reduction, both inactivation and removal, obtained by molecular methods should be interpreted carefully when considering treatment options to provide virus-safe drinking water. Combining culture-based methods with molecular methods may provide supplementary information on mechanisms of virus reduction.

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Hayashi, Kaori, Seiichiro Mitani, Hiroya Taniguchi, Satoshi Hamauchi, Keiji Sugiyama, Takahiro Tsushima, Kazunori Honda, et al. "Efficacy of panitumumab plus irinotecan versus cetuximab plus irinotecan in patients with wild-type KRAS exon2 metastatic colorectal cancer previously treated with bevacizumab within 6 months." Journal of Clinical Oncology 35, no. 4_suppl (February 1, 2017): 800. http://dx.doi.org/10.1200/jco.2017.35.4_suppl.800.

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800 Background: The ASPECCT study showed panitumumab (Pmab) is non-inferior to cetuximab (Cmab) for chemotherapy-refractory and intolerant wild-type (WT) KRAS exon2 metastatic colorectal cancer (mCRC). In the subgroup analysis, Pmab provided more favorable outcomes than Cmab for patients (pts) previously treated with bevacizumab (Bmab). However, some reports suggested that anti-EGFR antibody (anti-EGFR) efficacy was reduced when received within 6 months of last administration of Bmab. In this study, we aim to evaluate the difference in efficacy between Pmab and Cmab in pts who received prior Bmab and were treated with anti-EGFR after a short interval. Methods: We retrospectively evaluated pts treated with anti-EGFR and irinotecan (IRI) after failure of Bmab, fluoropyrimidine, oxaliplatin, and IRI at two institutions. The main inclusion criteria were WT KRAS exon2 mCRC, ECOG PS 0-2, and no prior administration of anti-EGFR within 6 months after Bmab. Results: From Sep. 2008 to Mar. 2016, 124 consecutive pts met the inclusion criteria (Pmab/Cmab, 30/94). Pts’ characteristics were as follows (Pmab/Cmab): median age (range): 63/62 (38-76/27-82); male, 63%/72%; ECOG PS 0, 43%/27%; PS1, 57%/66%; PS2 0%/7%; tumor in left colon, 87%/76%; histology (por, muc), 10%/16%; ≥2 metastases, 67%/66%; ≥1 subsequent therapy, 73%/63%. Overall response and disease control rates in Pmab/Cmab were 31%/26% and 69%/67%, respectively. In Pmab/Cmab, the median overall survival was 15.8/12.2 months (HR, 0.62; 95% CI, 0.4-0.97; P=0.04) and the median progression-free survival was 6.5/5.5 months (HR, 0.75; 95% CI, 0.49-1.16, P=0.20). The adjusted HR with 10 covariates such as age, gender, PS, tumor location, histology, primary tumor resection, number of metastatic sites, liver limited disease, time from diagnosis of metastasis and initiation date of anti-EGFR plus IRI was 0.61 for PFS (p=0.1) and 0.61 for OS (p=0.04). Conclusions: Pmab plus irinotecan showed favorable outcomes compared with Cmab plus irinotecan in pts with WT KRAS exon2 mCRC within 6 months between the last administration of Bmab and initial anti-EGFR.

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Possner, Anna, Elias Zubler, Oliver Fuhrer, Ulrike Lohmann, and Christoph Schär. "A Case Study in Modeling Low-Lying Inversions and Stratocumulus Cloud Cover in the Bay of Biscay." Weather and Forecasting 29, no. 2 (April 1, 2014): 289–304. http://dx.doi.org/10.1175/waf-d-13-00039.1.

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Abstract Many regional forecasting models struggle to simulate low-lying strong temperature inversions. To understand this apparent deficit for forecast improvements, a case study of a strong inversion occurring in the Bay of Biscay on 27 January 2003 is conducted. The event was characterized by extensive stratocumulus cloud cover beneath an extensive high pressure system in combination with a particularly strong inversion of 10–12 K at an altitude of 500–800 m. Simulations were performed at 2- and 12-km horizontal resolutions, with 60 vertical levels (13 levels within the first 1000 m), and with lead times of 12–72 h. The simulations were validated using in situ radiosonde and satellite data. Besides large-scale subsidence, turbulent vertical mixing is a key dynamical process for the formation of nocturnal inversions. Sensitivities to parameters for vertical mixing (the minimum threshold for eddy diffusivity and the turbulence length scale) are investigated. Results presented herein show the planetary boundary layer (PBL) profiles to be very sensitive to the minimum threshold applied for eddy diffusivity, whereas little sensitivity with respect to the turbulence length-scale parameter was found. PBL moisture and potential temperature θ profiles for hindcasts between 24- and 72-h lead times at both resolutions were adequately simulated. In simulations with an adequate representation of the vertical turbulent exchange, realistic cloud cover was simulated, while too high values of the aforementioned threshold produced a strong underestimation of the cloud cover. These results indicate that a realistic simulation of strong inversions and their associated cloud cover is feasible, provided the vertical turbulent exchange is adequately represented.

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Garrett, C. R., L. L. Siu, G. Giaccone, A. El-Khoueiry, J. Marshall, P. LoRusso, L. Velasquez, G. Kollia, P. He, and D. Feltquate. "A phase I study of BMS-582664 (brivanib alaninate), an oral dual inhibitor of VEGFR and FGFR tyrosine kinases, in combination with full-dose cetuximab in patients (pts) with advanced gastrointestinal malignancies (AGM) who failed prior therapy." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 14018. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.14018.

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14018 Background: Brivanib is an oral prodrug of BMS-540215, a dual tyrosine kinase inhibitor of VEGFR and FGFR signaling. Prior studies have validated both VEGF and EGF signaling pathways as targets in AGM. The MTD of single-agent brivanib is 800 mg qd (ASCO #3051, 2006). Methods: An open-label Phase I dose-escalation study of brivanib in combination with cetuximab was conducted in pts with AGM who failed prior therapy. Brivanib was given po Day 1 and qd from Day 8, starting at 320 mg. Cetuximab was given IV Day 8 (400 mg/m2) then weekly (250 mg/m2). Dose escalation of brivanib continued to 800 mg qd, when an expansion cohort for pts with colorectal cancer (CRC) was opened for additional safety and efficacy. Fresh tissue and blood sampling for biomarker and pharmacokinetic (PK) analysis was performed. FDG-PET was obtained at Baseline X 2, Days 15 and 56. Tumor response (modified WHO) was evaluated q 8 weeks. Results: 18 pts (15 CRC, 2 esophageal, 1 other) were treated with 320, 600 or 800 mg qd of brivanib in combination with cetuximab for a median of 8 weeks (range 1 - 20+). A single DLT, bilateral pulmonary emboli, occurred at 320 mg qd. Few treatment-related AEs occurred across the 3 cohorts (Table). PK/biomarker data is pending. Available FDG-PET results from measurements in 8 pts with 2–3 target lesions showed good baseline reproducibility in SUVpeak, SUVmean and SUVmax, with intra-subject CV of 3.6%, 7.2% and 9.3%, respectively. Conclusions: Brivanib in combination with full-dose cetuximab was well tolerated at ≤800 mg qd and did not result in enhancement of cetuximab associated AEs. Pre-treatment FDG-PET is a highly reproducible imaging modality. [Table: see text] [Table: see text]

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Florey, C. "Marquis Who's Who in Cancer: Professionals and Facilities. Chicago, Marquis Who's Who, Inc., 1985, pp 802, $150." International Journal of Epidemiology 15, no. 1 (March 1, 1986): 146. http://dx.doi.org/10.1093/ije/15.1.146.

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Finn, Richard S., Philippe Merle, Alessandro Granito, Yi-Hsiang Huang, Gyorgy Bodoky, Marc Pracht, Osamu Yokosuka, et al. "Outcomes with sorafenib (SOR) followed by regorafenib (REG) or placebo (PBO) for hepatocellular carcinoma (HCC): Results of the international, randomized phase 3 RESORCE trial." Journal of Clinical Oncology 35, no. 4_suppl (February 1, 2017): 344. http://dx.doi.org/10.1200/jco.2017.35.4_suppl.344.

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344 Background: SOR is standard first-line systemic treatment for HCC unsuitable for locoregional therapy. RESORCE showed that REG improves overall survival (OS) in patients who progressed during SOR treatment (HR 0.63, 95% CI 0.50, 0.79; P < 0.001). This exploratory analysis describes outcomes for the sequence of SOR followed by REG. Methods: 573 patients were randomized 2:1 to receive REG 160 mg/day (d), 3 wks on/1 wk off or PBO. Data on prior SOR treatment and radiologic progression were prospectively collected. Efficacy and safety were evaluated by the last SOR dose. Time from the start of SOR to death was assessed. Results: Baseline characteristics were balanced. Times from the start of SOR to progression on SOR and times from progression on SOR to start of study drug were similar (Table). When analyzed based on last SOR dose 800 mg/d vs < 800 mg/d, rates of all grade treatment-emergent adverse events (TEAEs) on study were similar (REG: 100% vs 100%; PBO: 92% vs 93%). TEAE grades 3/4/5 by last SOR dose 800 mg/d vs < 800 mg/d were 52/11/15% vs 61/10/12%, respectively, with REG and 30/8/24% vs 32/7/14% with PBO. HRs (95% CI) REG/PBO for OS by last SOR dose were similar: 0.67 (0.51, 0.87) for 800 mg/d and 0.68 (0.48, 0.97) for < 800 mg/d. Median OS (95% CI) from the start of SOR was 26.0 months (22.6, 28.1) for REG and 19.2 months (16.3, 22.8) for PBO. Clinical trial information: NCT01774344. Conclusions: This exploratory subgroup analysis by prior SOR dose demonstrates a consistent survival benefit for REG. In addition, the safety profile of REG was not remarkably different when analyzed by the last SOR dose.[Table: see text]

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Apostolopoulos, A., and M. Karavis. "Overeating: Treatment of Obesity and Anxiety by Auricular Acupuncture, An Analysis of 800 Cases." Acupuncture in Medicine 14, no. 2 (November 1996): 116–20. http://dx.doi.org/10.1136/aim.14.2.116.

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Auricular acupuncture (placement of press needles) was applied at the stomach point (according to Nogier) and sometimes at the point of psychological balance (Shenmen) for the control of anxiety and for help in weight loss in 800 patients over a two year period. Press needles were inserted and left in for 10 to 15 days at the auricular acupuncture point and resited again after 4 to 5 days. At the same time, instructions were given for the standard treatment of obesity (information leaflet, low calorie diet, aerobic exercise, behaviour modification, psychological support, etc.). The patients were followed up for a period of one year. The participants were 683 women and 117 men aged between 15 and 76 years. The Body Mass Index (weight/height) was used to determine the degree of obesity, and cases were divided into three groups according to the number of acupuncture sessions as follows: 468 patients (Group A) had one acupuncture session, 278 (Group B) 2 to 4 sessions, and 54 (Group C) had over 4 sessions, all conducted at 15 to 20 day intervals. A reduction in overeating was reported by 81.1% of patients, and 46.7% of the 697 patients who had noted anxiety symptoms claimed that treatment had helped in the reduction of anxiety. Regular exercise was encouraged, and started by 43.4% of the 703 who had no such habit. There was no significant weight loss in 35.2% of patients. During the first 3 months there was an overall significant weight loss in 64.8% and 35.5% at 6–12 months. The percentage weight loss was higher in Groups B and C and remained higher at six months and one year after the start of acupuncture treatment. Group B presented a good six month result in 61.2% of patients and a good annual result in 39.1%. In Group C results were 88.9% and 77.8% respectively. The control of overeating and anxiety using auricular acupuncture al the stomach and Shenmen points in this audit has been beneficial. Its correct use in an integrated obesity control programme may prove of significant long tem help.

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La Vignera, Sandro, Rosita A. Condorelli, Laura M. Mongioi, and Aldo E. Calogero. "Chronic Administration of Tadalafil Improves the Symptoms of Patients with Amicrobic MAGI: An Open Study." International Journal of Endocrinology 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/3848545.

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Aim of this study was to evaluate the effects of pharmacological treatment with Tadalafil 5 mg daily on symptoms and quality of sperm parameters in selected patients with amicrobic MAGI (male accessory gland inflammation). 120 patients with amicrobic MAGI (mean age 27.0 ± 6.0 years) with mild-moderate ED (erectile dysfunction) according to IIEF-5 (International Index of Erectile Function 5 Items) scores underwent pharmacological treatment with Tadalafil 5 mg daily for six months. Before and after treatment these patients were evaluated through IIEF-5, semen analysis (according to WHO Criteria, 2010), SI-MAGI (Structured Interview about Male Accessory Gland Inflammation), and ultrasound evaluation. Patients with PVE (prostate-vesciculo-epididymitis) showed a significant increase in the percentage of spermatozoa with total (16.0 ± 8.0 versus 30.0 ± 6.0%) and progressive motility (8.00 ± 10.0 versus 25.0 ± 6.00%). It was a significant reduction of the number of patients with complicated ultrasound forms (30.0 versus 52.0) and a significant increase of the number of patients with uncomplicated ultrasound form (90.0 versus 68.0). Finally, there was a significant reduction in the percentage of patients with alterations of sexual function different from DE, such as premature ejaculation (4.00 versus 8.00%), painful ejaculation (4.00 versus 10.0%), delayed ejaculation (12.50 versus 8.00%), and decreased libido (10.0 versus 25.0%).

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Liguori, G., S. De Stefani, S. Ciampalini, and E. Belgrano. "AMS 800® artificial sphincter: An unusual case of circumscribed peritonitis due to prosthethic reservoir infection." Urologia Journal 63, no. 1 (February 1996): 142–44. http://dx.doi.org/10.1177/039156039606300129.

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— We report the case of a patient who presented with circumscribed peritonitis due to infection of the intraperitoneal reservoir of an artificial sphincter. Although only parietal symptoms were evident, the balloon could not be removed without segmental ileal resection. This case suggests re-examining indications for intraperitoneal implantation of the reservoir.

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Li, Ping. "Study on the Correlation between Drawing Education and Special Cognitive Ability Evaluation Based on the MCT." Materials Science Forum 800-801 (July 2014): 684–87. http://dx.doi.org/10.4028/www.scientific.net/msf.800-801.684.

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Use the international universal theory of evaluation of special cognitive ability with Mental Cutting Test (MCT) to test the students of Science and Technology University. Compare the MCT average scores of fore-and-aft drawing education, it shows that the effect of descriptive geometry teaching is positive correlative with the scores of MCT, the students improved their special cognitive ability from planar drawing to three-dimensional drawing significantly. The students who got lower MCT scores before taking drawing courses improved their MCT scores obviously. The effect of mechanical drawing teaching is feeble correlative with the scores of MCT; it shows feeble improvement in students’ special cognitive ability.

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Yamamoto, Koji, Takashi Honda, Satoshi Suzuki, Hidenori Toyoda, Tadashi Matsushita, Tetsuhito Kojima, Hidemi Goto, and Junki Takamatsu. "Anti-HCV Agent, Ribavirin, Decreases Events of Bleeding in Hemophilia Patients, Possibly by Elevating the Clotting Activity of Factor VII." Blood 106, no. 11 (November 16, 2005): 3214. http://dx.doi.org/10.1182/blood.v106.11.3214.3214.

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Abstract Ribavirin has been used in combination with interferon-alpha (IFN-α) to treat chronic hepatitis C. This combination therapy has been reported to be more effective than IFN-α monotherapy for eradicating hepatitis C virus (HCV), including patients with concomitant hemophilia. Eight consecutive hemophilia patients were treated for HCV infection with IFN-α and ribavirin between June 2002 and May 2005 at Nagoya University Hospital as outpatients. Characteristics of patients and responses to anti-HCV treatment Patient Age (yrs) Hemophilia type Severity of hemophilia HIV infection Ribavirin load (mg/day) HCV genotype Eradication of HCV The eradication of HCV was considered positive when the absence of serum HCV RNA was maintained for 24 weeks after treatment was completed. 1 28 A moderate N 800 3a Yes 2 61 A severe N 800 3a Yes 3 50 A severe N 600 --> 400 1b No 4 42 B mild N 800 2a +1b Yes 5 44 A severe N 800 3a Yes 6 52 A mild N 600 2b Yes 7 37 A mild P 800 --> 600 1a No 8 44 B moderate N 800 1a Yes All patients were men with a mean age (SD) of 44.8 (10.0) years. Seven patients had hemophilia A, and 2 had hemophilia B. Hemophilia was severe in 4 patients, moderate in 2 and mild in 3. Four patients had been previously treated with IFN-α-2b alone (Intron A®, Schering Plough, K.K., Osaka, Japan) but HCV had not been eradicated. During this study, all patients were treated with the same 24-week regimen of IFN-α. Oral ribavirin (Rebetol, Schering-Plough, Kenilworth, N.J.) was administered at a dose of 600 mg/day for patients who weighed 60 kg or less and 800 mg/day for those who weighed more than 60 kg during 24 weeks. We observed the reduction of the frequency and dose of infusion with clotting factors as a hemostatic therapy in HCV-positive hemophilia patients who were administered with ribavirin. Figure Figure (Use of clotting factor concentrates 6 months before, during and 6 months after combination therapy with ribavirin and IFN-α. Use of clotting factors is presented as the average use per month.) In order to investigate the mechanism of this prophylactic effect of ribavirin to bleeding in hemophiliacs, we analyzed ribavirin-induced changes in the activity of factor VII in patients’ plasma. The clotting activity of factor VII in plasma has been elevated at 15% on an average in 9 HCV-positive hemophilia patients during treatment with ribavirin (without ribavirin: 86.3±7.6%; with ribavirin: 102.0±10.3%). Furthermore, a significant induction of factor VII mRNA was demonstrated in cultured normal human hepatocytes or HepG2 cells when treated with ribavirin at the therapeutic concentration. These observations indicate that ribavirin can elevate factor VII procoagulant activity in plasma, possibly due to the induction of factor VII in hepatocytes, thus, contributing to decreased events of bleeding in HCV-positive hemophiliacs.

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Journal articles on the topic 'WHF 800'

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